David Stokoe, Ph.D.

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d="M816.778 442.119c149.589 36.902 240.943 188.094 204.045 337.697-36.898 149.604-188.076 240.967-337.664 204.065-136.962-33.787-227.15-164.51-210.123-304.56C490.064 539.274 608.95 433.976 750.017 434l.007-36C576.07 397.97 435.03 538.975 435 712.945c-.03 173.97 140.961 315.025 314.914 315.055 159.269.028 293.495-118.856 312.72-276.976 19.225-158.12-82.6-305.711-237.235-343.858l-8.62 34.953z"></path><path d="M833.02 371.214c121.741 30.032 218.214 122.735 253.079 243.19 34.865 120.456 2.824 250.363-84.052 340.786-86.877 90.424-215.39 127.627-337.131 97.596-172.31-42.506-285.776-206.964-264.353-383.155C421.986 493.44 571.555 360.969 749.03 361l.006-36C535.32 324.963 362.037 498.198 362 711.932c-.037 213.735 173.184 387.03 386.9 387.068 195.677.034 360.586-146.023 384.206-340.285 23.62-194.262-101.482-375.588-291.465-422.453l-8.62 34.952z"></path><path d="M1095.71 952.143c-132.792 192.366-396.34 240.63-588.652 107.8C314.746 927.111 266.496 663.486 399.289 471.12c121.584-176.13 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468.399-466.306 350.3-777.801-108.13-285.202-412.194-444.82-708.412-371.88S112.733 481.314 149.45 784.1l35.757-4.335z"></path><path d="M222.654 348.554C352.501 160.51 572.805 56.021 800.58 74.45c227.776 18.427 428.417 156.972 526.346 363.445 97.929 206.473 78.266 449.507-51.58 637.552-183.783 266.155-537.33 353.231-823.698 202.87-286.367-150.36-415.424-490.835-300.677-793.238l-33.692-12.784c-132.386 348.89 43.125 739.04 392.015 871.427 348.89 132.386 739.04-43.125 871.427-392.015 121.211-319.44-15.116-679.096-317.617-837.928-302.5-158.832-675.966-66.85-870.103 214.3l29.653 20.476z"></path><path d="M417.175 1341.066C69.2 1158.357-64.775 728.151 117.934 380.176c182.709-347.977 612.915-481.952 960.89-299.242 318.604 167.287 462.189 546.088 334.525 882.532-127.664 336.445-486.396 524.642-835.776 438.463l-8.629 34.984c400.91 98.89 806.08-145.946 904.97-546.857 98.889-400.91-145.947-806.08-546.858-904.97C559.986-105.455 183.09 92.27 48.962 445.75c-134.127 353.48 16.728 751.461 351.463 927.22l16.75-31.903z"></path></g></g></svg> </div> <header class="entry-header container__medium-small"> <a href="https://www.calicolabs.com/people/#research-development" class="arrow_button small left"><svg height="7" viewBox="0 0 30 7" width="30" href="/people#leadership" class="Button__BackButtonIcon-sc-1t76fnu-5 hpPAOP"><g fill="none" stroke="#403C3C"><path d="M0 3.311L28.752 3.311M25.689 6.729L29 3.311 25.689 0" transform="rotate(-180 15 3.406)"></path></g></svg>Back to Senior R&D Staff</a> <div class="employee_header"> <figure class="employee_header__img"> <img data-src="https://www.calicolabs.com/wp-content/uploads/2020/04/stokoe_img@2x-1.jpg" alt="Portrait of David Stokoe, Ph.D." src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload" style="--smush-placeholder-width: 510px; --smush-placeholder-aspect-ratio: 510/730;" /><noscript><img src="https://www.calicolabs.com/wp-content/uploads/2020/04/stokoe_img@2x-1.jpg" alt="Portrait of David Stokoe, Ph.D."/></noscript> </figure> <div class="employee_header__content"> <h1 class="entry-title h3">David Stokoe, Ph.D.</h1> <span class="role t-label-small-medium">Head of Oncology</span> <div>David seeks to find novel drug targets through the use of cancer genomics and phenotypic screening.</div> <div></div> </div> </div> </header> <div class="entry-content container__medium-small"> <div class="share"> <div class="share_button_wrapper light"> <div class="share_button"> <div class="share_button_container"> <button class="share_button_svg_container"> <svg class="svg share" height="48" viewBox="0 0 48 48" width="48"><g fill="none" fill-rule="evenodd" transform="translate(1 1)"><circle cx="23" cy="23" r="23" stroke=""></circle><g stroke="" stroke-linecap="round" stroke-linejoin="round" stroke-width="2" transform="translate(13 13)"><circle cx="15" cy="3" r="3"></circle><circle cx="3" cy="10" r="3"></circle><circle cx="15" cy="17" r="3"></circle><path d="M5.59 11.51l6.83 3.98M12.41 4.51L5.59 8.49"></path></g></g></svg> </button> <div class="share_button_options"> <a class="share_button_options-link" target="_blank" href="https://www.facebook.com/sharer/sharer.php?u=https://www.calicolabs.com/people/david-stokoe-ph-d/ "> <svg height="30" viewBox="0 0 30 30" width="30"><g fill="none" fill-rule="evenodd"><circle cx="15" cy="15" r="14" stroke="#FFF" stroke-width="2"></circle><path fill="#FFF" d="M15.896 23.864h-3.325v-7.842h-1.662V13.32h1.662v-1.623c0-2.204.938-3.515 3.604-3.515h2.219v2.703h-1.387c-1.038 0-1.107.377-1.107 1.082l-.004 1.353h2.513l-.294 2.702h-2.22v7.842h.001z"></path></g></svg> </a> <a class=" share_button_options-link" target="_blank" href="https://twitter.com/share?url=https://www.calicolabs.com/people/david-stokoe-ph-d/ "> <svg height="30" viewBox="0 0 30 30" width="30"><g fill="none" fill-rule="evenodd"><circle cx="15" cy="15" r="14" stroke="#FFF" stroke-width="2"></circle><path fill="#FFF" d="M20.813 11.486a3.075 3.075 0 0 0 1.291-1.714 5.697 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1.584.693 1.603 1.607 0 .897-.622 1.608-1.621 1.608zm12.032 10.422h-3.014v-4.794c0-1.255-.471-2.11-1.508-2.11-.793 0-1.234.577-1.439 1.135-.077.199-.065.477-.065.757v5.012h-2.986s.039-8.492 0-9.264h2.986v1.454c.177-.635 1.13-1.543 2.653-1.543 1.89 0 3.373 1.334 3.373 4.202v5.151z"></path></g></svg> </a> <a class=" share_button_options-link" target="_blank" href="mailto:?body=https://www.calicolabs.com/people/david-stokoe-ph-d/ "> <svg height="30" viewBox="0 0 30 30" width="30"><g fill="none" fill-rule="evenodd"><circle cx="15" cy="15" r="14" stroke="#FFF" stroke-width="2"></circle><path fill="#FFF" d="M22.5 13.063v6.152c0 .34-.131.632-.393.875a1.343 1.343 0 0 1-.946.365H8.839c-.368 0-.683-.122-.946-.365a1.151 1.151 0 0 1-.393-.875v-6.152c.246.253.527.478.845.674 2.02 1.27 3.407 2.162 4.16 2.673.319.217.577.386.775.508.198.121.462.245.79.371.33.127.637.19.922.19h.017c.284 0 .591-.063.92-.19.33-.126.593-.25.791-.371.198-.122.456-.291.775-.508.948-.635 2.338-1.526 4.168-2.673.318-.201.597-.426.837-.674zm-1.34-3.518c.363 0 .677.122.942.365.265.242.398.534.398.875 0 .408-.137.798-.41 1.17a3.84 3.84 0 0 1-1.021.953 7005.44 7005.44 0 0 0-3.918 2.518l-.356.236a8.93 8.93 0 0 1-.887.546c-.17.093-.33.163-.481.21-.15.046-.29.07-.419.07h-.016c-.129 0-.268-.024-.419-.07a2.628 2.628 0 0 1-.481-.21 8.812 8.812 0 0 1-.436-.251c-.12-.075-.27-.173-.452-.295-.18-.121-.3-.2-.355-.236-.407-.264-.956-.619-1.648-1.063l-.545-.35c-.955-.613-1.527-.981-1.716-1.105a4.025 4.025 0 0 1-.98-.895c-.307-.38-.46-.732-.46-1.057 0-.403.116-.74.347-1.008.232-.268.563-.403.992-.403z"></path></g></svg> </a> </div> </div> </div> </div> </div> <div class="employee_content"> <div class="employee_content__section pb"> <h5 class="h6 markot">About</h5> <p>The Stokoe lab uses cancer genomics, combined with phenotypic screening, to identify and validate novel oncology drug targets.</p> <p>Following his postdoc at Onyx Pharmaceuticals, David moved to the University of California at San Francisco to start a lab working on signaling pathways deregulated in cancer. He then joined Genentech to apply some of these findings in a translational setting, and to pursue target identification through cancer genomics and analysis of epigenetic alterations.</p> </div> <div class="employee_content__section education"> <h5 class="t-label-small-medium underlined">Education:</h5> <ul class="employee_content__section_list no_bullets"> <li>Postdoc, Onyx Pharmaceuticals</li> <li>Ph.D. in Biochemistry, University of Dundee</li> <li>B.Sc. in Biochemistry, University of Bristol</li> </ul> </div> <div class="employee_content__section"> <h5 class="t-label-small-medium underlined">Featured Publications:</h5> <div class="employee_content__section_list"> <article class="publication_item from-bottom__0 no_meta"> <div class="share"> <div class="share_button_wrapper light"> <div class="share_button"> <div class="share_button_container"> <button class="share_button_svg_container"> <svg class="svg share" height="48" viewBox="0 0 48 48" width="48"><g fill="none" 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1-1.687.488z"></path></g></svg> </a> <a class=" share_button_options-link" target="_blank" href="https://www.linkedin.com/shareArticle?url=https://aacrjournals.org/cancerrescommun/article/4/2/540/734917/Inhibition-of-Aurora-Kinase-Induces-Endogenous "> <svg height="30" viewBox="0 0 30 30" width="30"><g fill="none" fill-rule="evenodd"><circle cx="15" cy="15" r="14" stroke="#FFF" stroke-width="2"></circle><path fill="#FFF" d="M8.526 12.554h2.658v9.263H8.526v-9.263zm1.26-1.158h-.018c-.962 0-1.586-.708-1.586-1.605 0-.915.642-1.61 1.623-1.61.98 0 1.584.693 1.603 1.607 0 .897-.622 1.608-1.621 1.608zm12.032 10.422h-3.014v-4.794c0-1.255-.471-2.11-1.508-2.11-.793 0-1.234.577-1.439 1.135-.077.199-.065.477-.065.757v5.012h-2.986s.039-8.492 0-9.264h2.986v1.454c.177-.635 1.13-1.543 2.653-1.543 1.89 0 3.373 1.334 3.373 4.202v5.151z"></path></g></svg> </a> <a class=" share_button_options-link" target="_blank" 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1-.481-.21 8.812 8.812 0 0 1-.436-.251c-.12-.075-.27-.173-.452-.295-.18-.121-.3-.2-.355-.236-.407-.264-.956-.619-1.648-1.063l-.545-.35c-.955-.613-1.527-.981-1.716-1.105a4.025 4.025 0 0 1-.98-.895c-.307-.38-.46-.732-.46-1.057 0-.403.116-.74.347-1.008.232-.268.563-.403.992-.403z"></path></g></svg> </a> </div> </div> </div> </div> </div> <div class="publication_item__content"> <a href="https://aacrjournals.org/cancerrescommun/article/4/2/540/734917/Inhibition-of-Aurora-Kinase-Induces-Endogenous" target="_self" class="t-list-label"> Inhibition of aurora kinase induces endogenous retroelements to induce a type I/III IFN response via RIG-I </a> </div> </article> <article class="publication_item from-bottom__0 no_meta"> <div class="share"> <div class="share_button_wrapper light"> <div class="share_button"> <div class="share_button_container"> <button class="share_button_svg_container"> <svg class="svg share" height="48" viewBox="0 0 48 48" width="48"><g fill="none" fill-rule="evenodd" 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</div> </div> </div> </div> <div class="publication_item__content"> <a href="https://www.nature.com/articles/s41467-024-45920-w" target="_self" class="t-list-label"> Structure of the p53 degradation complex from HPV16 </a> </div> </article> </div> </div> <div class="employee_content__section"> <h5 class="t-label-small-medium underlined">Calico Publications:</h5> <div class="employee_content__section_list"> <article class="publication_item from-bottom__0 no_meta"> <div class="share"> <div class="share_button_wrapper light"> <div class="share_button"> <div class="share_button_container"> <button class="share_button_svg_container"> <svg class="svg share" height="48" viewBox="0 0 48 48" width="48"><g fill="none" fill-rule="evenodd" transform="translate(1 1)"><circle cx="23" cy="23" r="23" stroke=""></circle><g stroke="" stroke-linecap="round" stroke-linejoin="round" stroke-width="2" transform="translate(13 13)"><circle cx="15" cy="3" r="3"></circle><circle cx="3" cy="10" 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.591-.063.92-.19.33-.126.593-.25.791-.371.198-.122.456-.291.775-.508.948-.635 2.338-1.526 4.168-2.673.318-.201.597-.426.837-.674zm-1.34-3.518c.363 0 .677.122.942.365.265.242.398.534.398.875 0 .408-.137.798-.41 1.17a3.84 3.84 0 0 1-1.021.953 7005.44 7005.44 0 0 0-3.918 2.518l-.356.236a8.93 8.93 0 0 1-.887.546c-.17.093-.33.163-.481.21-.15.046-.29.07-.419.07h-.016c-.129 0-.268-.024-.419-.07a2.628 2.628 0 0 1-.481-.21 8.812 8.812 0 0 1-.436-.251c-.12-.075-.27-.173-.452-.295-.18-.121-.3-.2-.355-.236-.407-.264-.956-.619-1.648-1.063l-.545-.35c-.955-.613-1.527-.981-1.716-1.105a4.025 4.025 0 0 1-.98-.895c-.307-.38-.46-.732-.46-1.057 0-.403.116-.74.347-1.008.232-.268.563-.403.992-.403z"></path></g></svg> </a> </div> </div> </div> </div> </div> <div class="publication_item__content"> <a href="https://www.nature.com/articles/s42004-024-01263-7" target="_self" class="t-list-label"> Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex </a> </div> </article> </div> </div> </div> </div> <footer class="entry-footer container"> <div class="related_employees"> <h5 class="t-label-small-medium mb-2 mobile-mb-2 from-bottom__0">See Other Senior R&D Staff Profiles</h5> <div class="related_employees__grid employee_grid__section cols_4 type_card active"> <article class="employee_grid__person employee_card type_card from-bottom__0"> <a href="https://www.calicolabs.com/people/subhabrata-sanyal-ph-d/"> <figure class="employee_card__img scale_img_on_hover"> <img data-src="https://www.calicolabs.com/wp-content/uploads/2020/04/subhabrata_img@2x-1.jpg" alt="Portrait of Subhabrata Sanyal, Ph.D." src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload" style="--smush-placeholder-width: 510px; --smush-placeholder-aspect-ratio: 510/730;" /><noscript><img src="https://www.calicolabs.com/wp-content/uploads/2020/04/subhabrata_img@2x-1.jpg" alt="Portrait of Subhabrata Sanyal, Ph.D."/></noscript> </figure> <div class="employee_card__content"> <span class="employee_card__name">Subhabrata Sanyal, Ph.D.</span> <span class="employee_card__title">Head of Translational Neurosciences</span> </div> </a> </article> <article class="employee_grid__person employee_card type_card from-bottom__0"> <a href="https://www.calicolabs.com/people/carmela-sidrauski-ph-d/"> <figure class="employee_card__img scale_img_on_hover"> <img data-src="https://www.calicolabs.com/wp-content/uploads/2020/04/Carmela_Sidrauski-4298-1-800x1200.jpg" alt="Portrait of Carmela Sidrauski, Ph.D." src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload" style="--smush-placeholder-width: 800px; --smush-placeholder-aspect-ratio: 800/1200;" /><noscript><img src="https://www.calicolabs.com/wp-content/uploads/2020/04/Carmela_Sidrauski-4298-1-800x1200.jpg" alt="Portrait of Carmela Sidrauski, Ph.D."/></noscript> </figure> <div class="employee_card__content"> <span class="employee_card__name">Carmela Sidrauski, Ph.D.</span> <span class="employee_card__title">Distinguished Principal Investigator</span> </div> </a> </article> <article class="employee_grid__person employee_card type_card from-bottom__0"> <a href="https://www.calicolabs.com/people/susan-uptain-ph-d/"> <figure class="employee_card__img scale_img_on_hover"> <img data-src="https://www.calicolabs.com/wp-content/uploads/2024/11/Susan_Uptain_0177-2-800x1200.jpg" alt="Portrait of Susan Uptain, Ph.D." src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload" style="--smush-placeholder-width: 800px; --smush-placeholder-aspect-ratio: 800/1200;" /><noscript><img src="https://www.calicolabs.com/wp-content/uploads/2024/11/Susan_Uptain_0177-2-800x1200.jpg" alt="Portrait of Susan Uptain, Ph.D."/></noscript> </figure> <div class="employee_card__content"> <span class="employee_card__name">Susan Uptain, Ph.D.</span> <span class="employee_card__title">Head of Project Team Leadership and 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