Drug Development

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--background-color:#01210e;--bg-position-x-dt:center;--bg-position-y-dt:center;--bg-position-x-mb:center;--bg-position-y-mb:center;--overlay:;"> <div class="hero__container"> <figure class="hero-background block_background background_type_image has_overlay bg_fill_dt_cover block_background__media " style="--background-color:#01210e;--bg-position-x-dt:center;--bg-position-y-dt:center;--bg-position-x-mb:center;--bg-position-y-mb:center;--overlay:; "><img decoding="async" data-src="https://www.calicolabs.com/wp-content/smush-webp/2022/10/female-scientist-in-lab-1-2-scaled-2000x1334.jpg.webp" data-srcset="https://www.calicolabs.com/wp-content/smush-webp/2022/10/female-scientist-in-lab-1-2-scaled-2000x1334.jpg.webp 2000w, https://www.calicolabs.com/wp-content/smush-webp/2022/10/female-scientist-in-lab-1-2-scaled-1200x801.jpg.webp 1200w, https://www.calicolabs.com/wp-content/smush-webp/2022/10/female-scientist-in-lab-1-2-scaled-768x512.jpg.webp 768w, https://www.calicolabs.com/wp-content/smush-webp/2022/10/female-scientist-in-lab-1-2-scaled-1536x1025.jpg.webp 1536w, https://www.calicolabs.com/wp-content/smush-webp/2022/10/female-scientist-in-lab-1-2-scaled-2048x1366.jpg.webp 2048w" data-sizes="(max-width:2000px) 100vw, 2000px" alt="" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload" style="--smush-placeholder-width: 2000px; --smush-placeholder-aspect-ratio: 2000/1334;" /><noscript><img decoding="async" src="https://www.calicolabs.com/wp-content/uploads/2022/10/female-scientist-in-lab-1-2-scaled-2000x1334.jpg" srcset="https://www.calicolabs.com/wp-content/uploads/2022/10/female-scientist-in-lab-1-2-scaled-2000x1334.jpg 2000w, https://www.calicolabs.com/wp-content/uploads/2022/10/female-scientist-in-lab-1-2-scaled-1200x801.jpg 1200w, https://www.calicolabs.com/wp-content/uploads/2022/10/female-scientist-in-lab-1-2-scaled-768x512.jpg 768w, https://www.calicolabs.com/wp-content/uploads/2022/10/female-scientist-in-lab-1-2-scaled-1536x1025.jpg 1536w, https://www.calicolabs.com/wp-content/uploads/2022/10/female-scientist-in-lab-1-2-scaled-2048x1366.jpg 2048w" sizes="(max-width:2000px) 100vw, 2000px" alt=""/></noscript></figure> <div class="hero__heading "> <div class="hero__heading__container"> <div class="hero__heading__title"> <h1 class="h1"> Aging is the greatest risk factor for disease </h1 > </div> <div class="hero__heading__description"> <p>We’re discovering new targets and developing first-in-class therapies for age-related diseases.</p> </div> </div> </div> <div class="hero__scroll__container"> <div class="hero__scroll"> <a href=""> <svg height="39" viewBox="0 0 39 39" width="39" class=""> <g> <g id="scroll-icon-arrow"> <rect y="-40" fill="none" stroke="none" width="40" height="80"></rect> <path d="M27.5,19.5c-0.3-0.3-0.8-0.3-1.1,0l-5.7,5.7V13c0-0.4-0.3-0.8-0.8-0.8s-0.8,0.3-0.8,0.8v12.2l-5.7-5.7 c-0.3-0.3-0.8-0.3-1.1,0s-0.3,0.8,0,1.1l7,7c0.1,0.1,0.2,0.1,0.2,0.2c0.1,0,0.2,0.1,0.3,0.1s0.2,0,0.3-0.1c0.1,0,0.2-0.1,0.2-0.2 l7-7C27.8,20.2,27.8,19.8,27.5,19.5z"> </path> <path d="M27.5-20.5c-0.3-0.3-0.8-0.3-1.1,0l-5.7,5.7V-27c0-0.4-0.3-0.8-0.8-0.8s-0.8,0.3-0.8,0.8v12.2l-5.7-5.7 c-0.3-0.3-0.8-0.3-1.1,0s-0.3,0.8,0,1.1l7,7c0.1,0.1,0.2,0.1,0.2,0.2c0.1,0,0.2,0.1,0.3,0.1s0.2,0,0.3-0.1c0.1,0,0.2-0.1,0.2-0.2 l7-7C27.8-19.8,27.8-20.2,27.5-20.5z"> </path> </g>  </g> </svg> </a> <div class="hero__scroll__line"></div> </div> </div> </div> </div> <section id="page_section_block_5490fcf346224d6b06c9faab512738cc" class="page-section mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default block_background background_type_image has_overlay bg_fill_dt_contain block_background__media " style="--background-color:#f5f4f5;--bg-position-x-dt:center;--bg-position-y-dt:top;--bg-position-x-mb:center;--bg-position-y-mb:top;--overlay:;--bg-width-dt:100%;"> <div class="acf-innerblocks-container"> <div id="sizing_container_block_5a31663f056a64c16039ccf3cd3fce28" class="sizing-container section__margin_auto container__small mt-default mb-6 pt-default pb-default mobile-mt-5 mobile-mb-default mobile-pt-default mobile-pb-default" style=""> <div class="sizing-container_wrapper"> <h2 id="heading_block_15436582bd783eb5803fa36b10463596" class="custom_heading from-bottom__0 mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default align-left align-left-mobile"> Different by design </h2> <p>Like much of the work we do at Calico, our development approach is different by design. Our efforts focus on identifying new targets — that are not currently being pursued by many others — based on our evolving understanding of the biology of aging and age-related diseases.</p> <p>We’re translating that research into first-in-class compounds to target diseases commonly linked with aging. In some cases, our targets are predicted to also target aging more generally, thus having the potential to extend the overall human healthspan.</p> </div> </div> <div id="sizing_container_block_a29affa55ab9369da76376717ce1dba7" class="sizing-container section__margin_auto container__large mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default" style=""> <div class="sizing-container_wrapper"> <div class="featuredCard mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default " id="featured_card_block_366728ae7be2e4be60c97f61811871ce" style=" "> <div class="featuredCard post-3691 lab_story type-lab_story status-publish has-post-thumbnail hentry category-technology from-bottom__0"> <div class="featuredCard__container">  <div class="featuredCard__ribbon from-bottom__0"> <p class="t-label-small"> Calico Stories </p> </div>  <div class="featuredCard__heading"> <div class="featuredCard__heading-container">   <div class="featuredCard__date from-bottom__0"> <span> December 4, 2023 </span> </div>  <div class="featuredCard__title from-bottom__0"> <h4> <a href="https://www.calicolabs.com/story/probing-the-entire-genome-to-pinpoint-novel-immunotherapy-targets-2/" target="_self"> Probing the entire genome to pinpoint novel immunotherapy targets </a> </h4> </div>  <p class="featuredCard__description t-body-large from-bottom__0"> As we grow older, our cells become more prone to damage and mutations, elevating cancer risk. The longer we live, the more chances these abnormalities have to progress…. </p>  </div>  <div class="featuredCard__buttons from-bottom__0"> <div class="primary-button"> <a id="3691" class="btn btn__outlined white " style="" href="https://www.calicolabs.com/story/probing-the-entire-genome-to-pinpoint-novel-immunotherapy-targets-2/" target="_self">Keep Reading</a> </div> <div class="secondary-button"> <a id="3691" class="btn btn__simple white " style="" href="https://www.calicolabs.com/calico-stories/" target="_self">See More Stories</a> </div> </div> </div>  <figure class="featuredCard__img"> <img decoding="async" data-src="https://www.calicolabs.com/wp-content/smush-webp/2023/11/Asset-14TIDE_v3_rectangle-1024x562.jpg.webp" data-srcset="https://www.calicolabs.com/wp-content/smush-webp/2023/11/Asset-14TIDE_v3_rectangle-1024x562.jpg.webp 1024w, https://www.calicolabs.com/wp-content/smush-webp/2023/11/Asset-14TIDE_v3_rectangle-300x165.jpg.webp 300w, https://www.calicolabs.com/wp-content/smush-webp/2023/11/Asset-14TIDE_v3_rectangle-768x422.jpg.webp 768w, https://www.calicolabs.com/wp-content/smush-webp/2023/11/Asset-14TIDE_v3_rectangle-1536x843.jpg.webp 1536w, https://www.calicolabs.com/wp-content/smush-webp/2023/11/Asset-14TIDE_v3_rectangle-2048x1125.jpg.webp 2048w" data-sizes="(max-width: 2000px) 100vw, 2000px" alt="" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload" style="--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024/562;"><noscript><img decoding="async" class="" src="https://www.calicolabs.com/wp-content/uploads/2023/11/Asset-14TIDE_v3_rectangle-1024x562.jpg" srcset="https://www.calicolabs.com/wp-content/uploads/2023/11/Asset-14TIDE_v3_rectangle-1024x562.jpg 1024w, https://www.calicolabs.com/wp-content/uploads/2023/11/Asset-14TIDE_v3_rectangle-300x165.jpg 300w, https://www.calicolabs.com/wp-content/uploads/2023/11/Asset-14TIDE_v3_rectangle-768x422.jpg 768w, https://www.calicolabs.com/wp-content/uploads/2023/11/Asset-14TIDE_v3_rectangle-1536x843.jpg 1536w, https://www.calicolabs.com/wp-content/uploads/2023/11/Asset-14TIDE_v3_rectangle-2048x1125.jpg 2048w" sizes="(max-width: 2000px) 100vw, 2000px" alt="" loading="lazy"></noscript> </figure> </div> </div> </div> </div> </div> <div id="sizing_container_block_1413cc6d7c92403aaedd95a493424f8a" class="sizing-container section__margin_auto container__small mt-5 mb-default pt-default pb-default mobile-mt-5 mobile-mb-default mobile-pt-default mobile-pb-default" style=""> <div class="sizing-container_wrapper"> <h2 id="heading_block_f1557604aafb2af446c51a8906240de7" class="custom_heading from-bottom__0 mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default align-left align-left-mobile"> Focused on patient benefit </h2> <p>We believe that focusing on new areas of biology and making big leaps in science and then translating these efforts into drug candidates for potential clinical development will lead to patient benefit. Our approach has yielded a portfolio comprised of more than 20 early- and late-stage preclinical compounds in cancer, neurological diseases, and tissue homeostasis and repair.<br><a href="https://www.calicolabs.com/patients">LEARN MORE ABOUT OUR CLINICAL TRIALS</a></p> </div> </div> </div> <figure class=" block_background background_type_image has_overlay bg_fill_dt_contain block_background__media " style="--background-color:#f5f4f5;--bg-position-x-dt:center;--bg-position-y-dt:top;--bg-position-x-mb:center;--bg-position-y-mb:top;--overlay:;--bg-width-dt:100%; "><img decoding="async" data-src="https://www.calicolabs.com/wp-content/uploads/2020/04/bg_graphic-1024x370.png" data-srcset="https://www.calicolabs.com/wp-content/uploads/2020/04/bg_graphic-1024x370.png 1024w, https://www.calicolabs.com/wp-content/uploads/2020/04/bg_graphic-300x108.png 300w, https://www.calicolabs.com/wp-content/uploads/2020/04/bg_graphic-768x277.png 768w, https://www.calicolabs.com/wp-content/smush-webp/2020/04/bg_graphic.png.webp 1376w" data-sizes="(max-width:2000px) 100vw, 2000px" alt="" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload" style="--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024/370;" /><noscript><img decoding="async" src="https://www.calicolabs.com/wp-content/uploads/2020/04/bg_graphic-1024x370.png" srcset="https://www.calicolabs.com/wp-content/uploads/2020/04/bg_graphic-1024x370.png 1024w, https://www.calicolabs.com/wp-content/uploads/2020/04/bg_graphic-300x108.png 300w, https://www.calicolabs.com/wp-content/uploads/2020/04/bg_graphic-768x277.png 768w, https://www.calicolabs.com/wp-content/uploads/2020/04/bg_graphic.png 1376w" sizes="(max-width:2000px) 100vw, 2000px" alt=""/></noscript></figure></section> <section id="page_section_block_575e3361ba1bf887bd147dafc1408483" class="page-section mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default block_background background_type_color sbg_top sbg_top_dt_custom sbg_top_mb_none sbg_top_above" style="--background-color:#ffffff;--sbg-top-size-dt:150px;--sbg-top-color:#f5f4f5;"> <div class="acf-innerblocks-container"> <div id="sizing_container_block_04101e64698b662d323f62007e336498" class="sizing-container section__margin_auto container__default mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default" style=""> <div class="sizing-container_wrapper"> <figure class="media_block from-bottom__0 no_aspect_ratio mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default media_type_image alignment_dt_left alignment_mb_left size_dt_auto size_mb_auto" id="media_block_block_ba5bd428acc756d59af6b04d8179510d" style=""> <img decoding="async" data-src="https://www.calicolabs.com/wp-content/uploads/2024/07/Kenyon-Lab-2000x1334.jpg" data-srcset="https://www.calicolabs.com/wp-content/uploads/2024/07/Kenyon-Lab-2000x1334.jpg 2000w, https://www.calicolabs.com/wp-content/uploads/2024/07/Kenyon-Lab-1200x800.jpg 1200w, https://www.calicolabs.com/wp-content/uploads/2024/07/Kenyon-Lab-768x512.jpg 768w, https://www.calicolabs.com/wp-content/uploads/2024/07/Kenyon-Lab-1536x1025.jpg 1536w, https://www.calicolabs.com/wp-content/uploads/2024/07/Kenyon-Lab-2048x1366.jpg 2048w" data-sizes="(max-width: 2000px) 100vw, 2000px" alt="" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload" style="--smush-placeholder-width: 2000px; --smush-placeholder-aspect-ratio: 2000/1334;"><noscript><img decoding="async" class="" src="https://www.calicolabs.com/wp-content/uploads/2024/07/Kenyon-Lab-2000x1334.jpg" srcset="https://www.calicolabs.com/wp-content/uploads/2024/07/Kenyon-Lab-2000x1334.jpg 2000w, https://www.calicolabs.com/wp-content/uploads/2024/07/Kenyon-Lab-1200x800.jpg 1200w, https://www.calicolabs.com/wp-content/uploads/2024/07/Kenyon-Lab-768x512.jpg 768w, https://www.calicolabs.com/wp-content/uploads/2024/07/Kenyon-Lab-1536x1025.jpg 1536w, https://www.calicolabs.com/wp-content/uploads/2024/07/Kenyon-Lab-2048x1366.jpg 2048w" sizes="(max-width: 2000px) 100vw, 2000px" alt="" loading="lazy"></noscript> </figure> </div> </div> <div id="sizing_container_block_1413cc6d7c92403aaedd95a493424f8a" class="sizing-container section__margin_auto container__small mt-5 mb-default pt-default pb-default mobile-mt-5 mobile-mb-default mobile-pt-default mobile-pb-default" style=""> <div class="sizing-container_wrapper"> <h2 id="heading_block_6a4afef5eb052ced3daf42facf7397ae" class="custom_heading from-bottom__0 mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default align-left align-left-mobile"> Born of collaboration and partnership </h2> <p>Our clinical development efforts are powered by collaboration, both within Calico and with our external partners. For example, we work closely with the Broad Institute of MIT and Harvard on drug discovery programs, most notably a target screening program that has yielded a number of promising immunotherapy cancer targets we are actively pursuing.</p> <p>Our major partnership with the pharmaceutical company <a href="https://calicolabs.com/press/abbvie-and-calico-announce-extension-of-groundbreaking-collaboration"><strong>AbbVie</strong></a> provides us with additional research insights and capabilities, and also with the scale and scope necessary to bring a new medicine to patients while maintaining our focus on target discovery and early-stage clinical development. Calico is responsible for preclinical and clinical development through human proof of concept studies, with AbbVie having the option to assume responsibility for late-stage clinical development and commercialization. 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overlay.id = "nsl-redirect-overlay"; let overlayHTML = ''; const overlayContainer = "<div id='nsl-redirect-overlay-container'>", overlayContainerClose = "</div>", overlaySpinner = "<div id='nsl-redirect-overlay-spinner'></div>", overlayTitle = "<p id='nsl-redirect-overlay-title'>" + scriptOptions._localizedStrings.redirect_overlay_title + "</p>", overlayText = "<p id='nsl-redirect-overlay-text'>" + scriptOptions._localizedStrings.redirect_overlay_text + "</p>"; switch (scriptOptions._redirectOverlay) { case "overlay-only": break; case "overlay-with-spinner": overlayHTML = overlayContainer + overlaySpinner + overlayContainerClose; break; default: overlayHTML = overlayContainer + overlaySpinner + overlayTitle + overlayText + overlayContainerClose; break; } overlay.insertAdjacentHTML("afterbegin", overlayHTML); document.body.appendChild(overlay); } window.location = url; }; let targetWindow = scriptOptions._targetWindow || 'prefer-popup', lastPopup = false; document.addEventListener('click', function (e) { if (e.target) { const buttonLinkElement = e.target.closest('a[data-plugin="nsl"][data-action="connect"]') || e.target.closest('a[data-plugin="nsl"][data-action="link"]'); if (buttonLinkElement) { if (lastPopup && !lastPopup.closed) { e.preventDefault(); lastPopup.focus(); } else { let href = buttonLinkElement.href, success = false; if (href.indexOf('?') !== -1) { href += '&'; } else { href += '?'; } const redirectTo = buttonLinkElement.dataset.redirect; if (redirectTo === 'current') { href += 'redirect=' + encodeURIComponent(window.location.href) + '&'; } else if (redirectTo && redirectTo !== '') { href += 'redirect=' + encodeURIComponent(redirectTo) + '&'; } if (targetWindow !== 'prefer-same-window' && checkWebView()) { targetWindow = 'prefer-same-window'; } if (targetWindow === 'prefer-popup') { lastPopup = NSLPopup(href + 'display=popup', 'nsl-social-connect', buttonLinkElement.dataset.popupwidth, buttonLinkElement.dataset.popupheight); if (lastPopup) { success = true; e.preventDefault(); } } else if (targetWindow === 'prefer-new-tab') { const newTab = window.open(href + 'display=popup', '_blank'); if (newTab) { if (window.focus) { newTab.focus(); } success = true; window._nslHasOpenedPopup = true; e.preventDefault(); } } if (!success) { window.location = href; e.preventDefault(); } } } } }); let buttonCountChanged = false; const googleLoginButtons = document.querySelectorAll(' a[data-plugin="nsl"][data-provider="google"]'); if (googleLoginButtons.length && checkWebView()) { googleLoginButtons.forEach(function (googleLoginButton) { if (scriptOptions._unsupportedWebviewBehavior === 'disable-button') { disableButtonInWebView(googleLoginButton); } else { googleLoginButton.remove(); buttonCountChanged = true; } }); } const facebookLoginButtons = document.querySelectorAll(' a[data-plugin="nsl"][data-provider="facebook"]'); if (facebookLoginButtons.length && checkWebView() && /Android/.test(window.navigator.userAgent) && !isAllowedWebViewForUserAgent('facebook')) { facebookLoginButtons.forEach(function (facebookLoginButton) { if (scriptOptions._unsupportedWebviewBehavior === 'disable-button') { disableButtonInWebView(facebookLoginButton); } else { facebookLoginButton.remove(); buttonCountChanged = true; } }); } const separators = document.querySelectorAll('div.nsl-separator'); if (buttonCountChanged && separators.length) { separators.forEach(function (separator) { const separatorParentNode = separator.parentNode; if (separatorParentNode) { const separatorButtonContainer = separatorParentNode.querySelector('div.nsl-container-buttons'); if (separatorButtonContainer && !separatorButtonContainer.hasChildNodes()) { separator.remove(); } } }) } });})();</script> </body> </html>

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