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(PDF) Chromosomal Damage Risk Assessment to Benzene Exposure | Alexander Decker - Academia.edu
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true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":1291970,"created_at":"2012-01-25T22:46:41.660-08:00","from_world_paper_id":null,"updated_at":"2024-11-12T06:13:36.999-08:00","_data":{"grobid_abstract":"This study was a cross-sectional survey study to assess relative risk (RR) of chromosomal damage through benzene exposure in 45 gasoline stations workers compared to 30 controls in central area of Bangkok. Sister chromatid exchange (SCE) is as genotoxic biomarker, performed in white blood cells, and blood benzene level (BBL) is a biological marker of benzene exposure was performed by gas chromatographyflame ionization detector (GC-FID) using modified headspace solid-phase micro-extraction (HS-SPME) technique. The results showed that the average blood benzene level of these workers was significantly higher than in the controls (p \u003c 0.001) as well as the frequency of sister chromatid exchange. The sister chromatid exchange was strongly and positively associated with blood benzene level of gasoline workers (p \u003c 0.001) with the chromosomal damage relative risk at 2.50 (p \u003c 0.001).","grobid_abstract_attachment_id":"7940413"},"document_type":"paper","pre_hit_view_count_baseline":0,"quality":"high","language":"en","title":"Chromosomal Damage Risk Assessment to Benzene Exposure","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [1020414]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div 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class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Chromosomal Damage Risk Assessment to Benzene Exposure</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="1020414" href="https://independent.academia.edu/AlexanderDecker"><img alt="Profile image of Alexander Decker" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/1020414/2694441/3136463/s65_alexander.decker.jpg" />Alexander Decker</a></div><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":7940413,"attachmentType":"pdf","workUrl":"https://www.academia.edu/1291970/Chromosomal_Damage_Risk_Assessment_to_Benzene_Exposure"}">See full PDF</button><button class="ds2-5-button 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data-collection-position="0" data-entity-id="1545014" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/1545014/11_Chromosomal_Damage_Risk_Assessment_to_Benzene_Exposure">11.Chromosomal Damage Risk Assessment to Benzene Exposure</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="1020414" href="https://independent.academia.edu/AlexanderDecker">Alexander Decker</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"11.Chromosomal Damage Risk Assessment to Benzene Exposure","attachmentId":13096431,"attachmentType":"pdf","work_url":"https://www.academia.edu/1545014/11_Chromosomal_Damage_Risk_Assessment_to_Benzene_Exposure","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/1545014/11_Chromosomal_Damage_Risk_Assessment_to_Benzene_Exposure"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="76151334" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/76151334/Genotoxic_Effects_of_Benzene_in_Petrol_Station_Workers_in_Duhok_Kurdistan_Region_of_Iraq">Genotoxic Effects of Benzene in Petrol Station Workers in Duhok- Kurdistan Region of Iraq</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36918804" href="https://independent.academia.edu/MarwanKhalilQader">Marwan Khalil Qader</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2019</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Occupational exposures represent complex mixture of genotoxic agents. Benzene is one of the major organic product, people with chronic exposure to this organic product are exposed to many malignant disorders. People who work in Petrol station are consistently exposed to the dangerous components of petroleum through inhalation or direct contact with their skin. Objective: The aim of this study was to evaluate the potential cytogenetic damage and micronuclei frequency associated with occupational exposure to benzene among petrol station workers by using Micronucleus assay. Materials and Methods: The study groups included twenty five occupationally exposed petrol station workers and twenty five age matched controls were recruited and evaluated for genetic damage. Exfoliated Buccal cells were collected from both groups by using the sterile brush. Slides fixed in ethanol and stained with Giemsa stain and 1000 cells were studied by using a light microscope. Statistical analysi...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Genotoxic Effects of Benzene in Petrol Station Workers in Duhok- Kurdistan Region of Iraq","attachmentId":83927337,"attachmentType":"pdf","work_url":"https://www.academia.edu/76151334/Genotoxic_Effects_of_Benzene_in_Petrol_Station_Workers_in_Duhok_Kurdistan_Region_of_Iraq","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/76151334/Genotoxic_Effects_of_Benzene_in_Petrol_Station_Workers_in_Duhok_Kurdistan_Region_of_Iraq"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="81194117" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/81194117/Lymphocyte_chromosome_breakage_in_low_benzene_exposure_among_Indonesian_workers">Lymphocyte chromosome breakage in low benzene exposure among Indonesian workers</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31928115" href="https://independent.academia.edu/DewiSoemarko">Dewi Soemarko</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Medical Journal of Indonesia, 2015</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Benzene has been used in industry since long time and its level in environment should be controled. Although environmental benzene level has been controlled to less than 1 ppm, negative effect of benzene exposure is still observed, such as chromosome breakage. This study aimed to know the prevalence of lymphocyte chromosome breakage and the influencing factors among workers in low level benzene exposure.Methods: This was a cross sectional study in oil & gas industry T, conducted between September 2007 and April 2010. The study subjects consisted of 115 workers from production section and head office. Data on type of work, duration of benzene exposure, and antioxidant consumption were collected by interview as well as observation of working process. Lymphocyte chromosome breakage was examined by banding method. Analysis of relationship between chromosome breakage and risk factors was performed by chi-square and odd ratio, whereas the role of determinant risk factors was a...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Lymphocyte chromosome breakage in low benzene exposure among Indonesian workers","attachmentId":87324394,"attachmentType":"pdf","work_url":"https://www.academia.edu/81194117/Lymphocyte_chromosome_breakage_in_low_benzene_exposure_among_Indonesian_workers","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/81194117/Lymphocyte_chromosome_breakage_in_low_benzene_exposure_among_Indonesian_workers"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="12478255" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/12478255/Low_air_levels_of_benzene_Correlation_between_biomarkers_of_exposure_and_genotoxic_effects">Low air levels of benzene: Correlation between biomarkers of exposure and genotoxic effects</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31324191" href="https://independent.academia.edu/PieroLovreglio">Piero Lovreglio</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Toxicology Letters, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Low air levels of benzene: Correlation between biomarkers of exposure and genotoxic effects","attachmentId":46153583,"attachmentType":"pdf","work_url":"https://www.academia.edu/12478255/Low_air_levels_of_benzene_Correlation_between_biomarkers_of_exposure_and_genotoxic_effects","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/12478255/Low_air_levels_of_benzene_Correlation_between_biomarkers_of_exposure_and_genotoxic_effects"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="96222341" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/96222341/A_Quantitative_Meta_Analysis_of_the_Relation_between_Occupational_Benzene_Exposure_and_Biomarkers_of_Cytogenetic_Damage">A Quantitative Meta-Analysis of the Relation between Occupational Benzene Exposure and Biomarkers of Cytogenetic Damage</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="199497754" href="https://independent.academia.edu/BerniceScholten">Bernice Scholten</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Environmental Health Perspectives, 2020</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link 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style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="45319419" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/45319419/Environmental_and_occupational_exposure_to_benzene_in_Thailand">Environmental and occupational exposure to benzene in Thailand</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="49208178" href="https://independent.academia.edu/SiriratChanvaivit">Sirirat Chanvaivit</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Chemico-Biological Interactions, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Environmental and occupational exposure to benzene in Thailand","attachmentId":65865053,"attachmentType":"pdf","work_url":"https://www.academia.edu/45319419/Environmental_and_occupational_exposure_to_benzene_in_Thailand","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/45319419/Environmental_and_occupational_exposure_to_benzene_in_Thailand"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="62819354" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/62819354/Cytogenetic_changes_in_subjects_occupationally_exposed_to_benzene">Cytogenetic changes in subjects occupationally exposed to benzene</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33146506" href="https://independent.academia.edu/KarmelaSentija">Karmela Sentija</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Chemosphere, 2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cytogenetic changes in subjects occupationally exposed to benzene","attachmentId":75465370,"attachmentType":"pdf","work_url":"https://www.academia.edu/62819354/Cytogenetic_changes_in_subjects_occupationally_exposed_to_benzene","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/62819354/Cytogenetic_changes_in_subjects_occupationally_exposed_to_benzene"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="54008333" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/54008333/Environmental_Assessment_and_Evaluation_of_Oxidative_Stress_and_Genotoxicity_Biomarkers_Related_to_Chronic_Occupational_Exposure_to_Benzene">Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="118142759" href="https://independent.academia.edu/RitaMattos2">Rita Mattos</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Environmental Research and Public Health</p><p class="ds-related-work--abstract ds2-5-body-sm">Environmental and occupational exposure to benzene from fuels is a major cause for concern for national and international authorities, as benzene is a known carcinogen in humans and there is no safe limit for exposure to carcinogens. The objective of this study was to evaluate the genotoxic effects of chronic occupational exposure to benzene among two groups of workers: filling station workers (Group I) and security guards working at vehicles entrances (Group II), both on the same busy highway in Rio de Janeiro, Brazil. Sociodemographic data on the workers were evaluated; the concentration of benzene/toluene (B/T) in atmospheric air and individual trans,trans-muconic acid (ttMA) and S-phenylmercapturic acid (S-PMA) were measured; oxidative stress was analyzed by catalase (CAT), glutathione S-transferase (GST), superoxide dismutase (SOD), thiol groups (THIOL) and malondialdehyde (MDA); genotoxicity was measured by metaphases with chromosomal abnormalities (MCA) and nuclear abnormalit...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene","attachmentId":70579769,"attachmentType":"pdf","work_url":"https://www.academia.edu/54008333/Environmental_Assessment_and_Evaluation_of_Oxidative_Stress_and_Genotoxicity_Biomarkers_Related_to_Chronic_Occupational_Exposure_to_Benzene","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/54008333/Environmental_Assessment_and_Evaluation_of_Oxidative_Stress_and_Genotoxicity_Biomarkers_Related_to_Chronic_Occupational_Exposure_to_Benzene"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="55509245" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/55509245/Interphase_cytogenetics_of_workers_exposed_to_benzene">Interphase cytogenetics of workers exposed to benzene</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="66419086" href="https://independent.academia.edu/ZhangLuoping">Luoping Zhang</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Environmental Health Perspectives, 1996</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Interphase cytogenetics of workers exposed to benzene","attachmentId":71346584,"attachmentType":"pdf","work_url":"https://www.academia.edu/55509245/Interphase_cytogenetics_of_workers_exposed_to_benzene","alternativeTracking":true}"><span 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