Protein Variant Applications

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<highlight> Single-molecule Resolution</highlight> on Platinum®</h1> <p>Unlock new protein insights through the detection of protein variants using Next-Generation Protein Sequencing™ on Platinum.</p> <a href="/contact/" class="button" target="">Request More Info</a> </div> </div> </section> <section class="text-image" data-block_aa539cf64dead4335ab221855c4ad4c6 id="text-image-why-choose-platinum-for-protein-variant-detection"> <div class="row medium-unstack align-middle "> <div class="column"> <span class="applications-header"> <a href="https://www.quantum-si.com/applications/">Applications</a> <span class="arrow">&rsaquo;</span> Protein Variant </span> <h2> Why Choose Platinum for Protein Variant Detection? </h2> <p> <p>Next-Generation Protein Sequencing on Platinum delivers unmatched single-molecule resolution for detecting single amino acid variants on a benchtop instrument.</p> <h2>Learn how Platinum has been used to detect protein variants in  the following applications:</h2> <ul> <li>Detection of spike protein variants from SARS-CoV-2 alpha, delta, and omicron variants</li> <li>Distinguish arginine and citrulline PTM sites</li> <li>Recognition of amino acid misincorporation events in ubiquitin protein variant</li> </ul> </p> <a href="/products/" target="" class="button">Learn More About Platinum</a> </div> </div> </section> <section class="video-player" data-block_279cdfe2ec6a4f3fff7d48402919d17c> <div class="row align-center"> <div class="column small-12 xlarge-11 text-center"> <h2 class="underline">Next-Generation Protein Sequencing™ to Detect Disease-Relevant Proteoforms</h2> <div class="video-wrapper"> <div class="responsive-embed widescreen"> <video src="https://www.quantum-si.com/wp-content/uploads/QSI-VIDEO-009-FoG-Sheynkman-062024.mp4" poster="https://www.quantum-si.com/wp-content/uploads/preview_gloria_sheynkman-1024x576.png"></video> <div class="play-button"> <span class="material-symbols-outlined">play_arrow</span> </div> </div> <div class="video-controls row large-"> <div class="column small-12"> <div class="slider time-slider" data-slider data-initial-start="0" data-end="100" step="0"> <span class="slider-handle time-slider-handle" data-slider-handle role="slider" tabindex="1"></span> <span class="slider-fill time-slider-fill" data-slider-fill></span> <input type="hidden" class="time-slider-value"> </div> </div> <div class="column"> <div class="row"> <div class="column shrink icons"> <span class="playpause" data-state="play"> <span class="play-icon material-symbols-outlined">play_arrow</span> <span class="pause-icon material-symbols-outlined">pause</span> </span> <span class="stop"></span> <span class="mute" data-state="mute"> <span class="unmute-icon material-symbols-outlined">volume_up</span> <span class="mute-icon material-symbols-outlined">volume_off</span> </span> </div> <div class="column shrink icons show-for-large"> <div class="slider volume-slider" data-slider data-initial-start="50" data-end="100"> <span class="slider-handle volume-slider-handle" data-slider-handle role="slider" tabindex="1"></span> <span class="slider-fill volume-slider-fill" data-slider-fill></span> <input type="hidden" class="volume-slider-value"> </div> </div> <div class="column time"> <span class="time-current">0:00</span> / <span class="time-total">0:00</span> </div> </div> </div> <div class="column text-right shrink"> <span class="pip material-symbols-outlined">picture_in_picture_alt</span> <span class="fs material-symbols-outlined">fullscreen</span> </div> </div> </div> <p> Dr. Gloria Sheynkman of the University of Virginia highlights the importance of detecting protein isoforms for understanding human traits and diseases. She introduces a novel long-read proteogenomics workflow to enhance protein isoform detection. Additionally, she describes how the Platinum® Next-Generation Protein Sequencer™ offers single-molecule protein sequencing technology with high sensitivity and resolution. </p> </div> </div> </section> <section class="accordion-section" data-block_9252fb0814fe9ac11bc32268eb704cfc> <div class="row"> <div class="column"> <h3>Dive into our application notes to grasp how Platinum, the Next-Generation Protein Sequencer™, optimizes protein variant detection with unparalleled precision.</h3> <ul class="accordion" data-accordion data-allow-all-closed="true"> <li class="accordion-item" data-accordion-item> <a href="#" class="accordion-title">Protein Sequencing With Single-Amino Acid Resolution Discerns Peptides That Discriminate Tropomyosin Proteoforms</a> <div class="accordion-content" data-tab-content> <p>Protein variants of the same gene–proteoforms–can have high molecular similarity yet exhibit different biological functions. Thus, identifying unique peptides that unambiguously map to proteoforms can provide crucial biological insights. In humans, four human tropomyosin (TPM) genes produce similar proteoforms that can be challenging to distinguish with standard proteomics tools.</p> <p>Dr. Gloria Sheynkman and her team at the University of Virginia School of Medicine have published a preprint on BioRxiv showcasing the capabilities of the Platinum® Next-Generation Protein Sequencer™ in advancing their research in this complex area of study.</p> <p><a class="wp-block-button__link has-black-color has-text-color wp-element-button" href="/resources/publications/protein-sequencing-with-single-amino-acid-resolution-discerns-peptides-that-discriminate-tropomyosin-proteoforms/">Download the Paper</a></p> </div> </li> <li class="accordion-item" data-accordion-item> <a href="#" class="accordion-title">Quantum-Si’s Next Generation Protein Sequencing Technology Enables Rapid and Accurate Distinction of Variants of the SARS-CoV-2 Virus — APP NOTE</a> <div class="accordion-content" data-tab-content> <p>This application note showcases Quantum-Si’s protein sequencing technology on the Platinum instrument, which enables the rapid and accurate distinction of variants of the SARS-CoV-2 virus based on differences in the amino acid sequence of their Spike proteins. By identifying and tracking these variants, scientists can better understand their impact on public health and develop effective treatments and vaccines.</p> <p>Download the application note to learn more about this groundbreaking technology.</p> <p><a class="wp-block-button__link has-black-color has-text-color wp-element-button" href="https://www.quantum-si.com/resources/app-notes/quantum-sis-next-generation-protein-sequencing-technology-enables-rapid-and-accurate-distinction-of-variants-of-the-sars-cov-2-virus/">Download the Application Note</a></p> <figure><img fetchpriority="high" decoding="async" class="wp-image-901" src="https://www.quantum-si.com/wp-content/uploads/2023/08/Website-Image-1.jpg" sizes="(max-width: 758px) 100vw, 758px" srcset="https://www.quantum-si.com/wp-content/uploads/2023/08/Website-Image-1.jpg 758w, https://www.quantum-si.com/wp-content/uploads/2023/08/Website-Image-1-300x159.jpg 300w" alt="" width="758" height="403" /></figure> <p>Focusing on a key mutation, we observed the distinctive kinetic influences on recognizer binding. The clear differences in pulse durations (PD) between the peptides of interest highlight the power of Quantum-Si’s Platinum instrument in differentiating the Alpha variant from the Delta and Omicron variants through a single mutation.</p> <p>Here we highlight the differentiation of the Omicron variant from the Alpha and Delta variants based on the detection of a single peptide. The capability to identify variant-specific peptides contributes to the accurate and precise distinction of SARS-CoV-2 variants using Quantum-Si’s Platinum instrument.</p> <figure><img decoding="async" class="wp-image-902" src="https://www.quantum-si.com/wp-content/uploads/2023/08/Screenshot-2023-05-26-at-12.17-1.jpg" sizes="(max-width: 926px) 100vw, 926px" srcset="https://www.quantum-si.com/wp-content/uploads/2023/08/Screenshot-2023-05-26-at-12.17-1.jpg 926w, https://www.quantum-si.com/wp-content/uploads/2023/08/Screenshot-2023-05-26-at-12.17-1-300x73.jpg 300w, https://www.quantum-si.com/wp-content/uploads/2023/08/Screenshot-2023-05-26-at-12.17-1-768x187.jpg 768w" alt="" width="926" height="225" /></figure> </div> </li> <li class="accordion-item" data-accordion-item> <a href="#" class="accordion-title"> Single-Molecule Protein Sequencing on the Quantum-Si Platform: Advances in Protein and Proteoform Identification and Comparison With Mass Spectrometry — POSTERS</a> <div class="accordion-content" data-tab-content> <p>Studies of the proteome would benefit greatly from methods to directly sequence and digitally quantify proteins and detect post-translational modifications with single-molecule sensitivity. Quantum-Si™ has developed the Platinum™ next-generation protein sequencing™ platform to offer a convenient benchtop solution for direct sequencing of single protein molecules with the aim of making protein sequencing accessible to any research lab. Quantum-Si has improved fundamentals of the assay components and platform allowing for increased coverage across the proteome.</p> <ul class="protein-varient-list"> <li>This poster describes these Platinum improvements and how they have resulted in unprecedented read depth and the identification of previously unseen proteins, leading to new insights and greater confidence in protein identification.</li> </ul> <p><a class="wp-block-button__link has-black-color has-text-color wp-element-button" href="https://www.quantum-si.com/resources/posters/single-molecule-protein-sequencing-on-the-quantum-si-platform-advances-in-protein-and-proteoform-identification-and-comparison-with-massspectrometry/">Download Poster</a></p> </div> </li> <li class="accordion-item" data-accordion-item> <a href="#" class="accordion-title"> Platinum® Next-Generation Protein Sequencing Advanced Data Analysis — TECHNICAL NOTE</a> <div class="accordion-content" data-tab-content> <p>Next-Generation Protein Sequencing™ (NGPS) on Platinum® enables protein identification and characterization with single-molecule and single amino acid resolution in a simple workflow using a benchtop instrument. Platinum Analysis Software workflows make peptide alignment and protein mapping easy to interpret without the need for advanced expertise. The output files from Platinum Analysis Software provide researchers with the opportunity to perform advanced analysis on NGPS data including analysis of amino acid variants and modifications based on kinetic signatures.</p> <ul class="protein-varient-list"> <li>This technical note provides guidance on interpreting results from Primary Analysis and Peptide Alignment Workflows and performing advanced analysis on NGPS data generated by Platinum.</li> </ul> <p><a class="wp-block-button__link has-black-color has-text-color wp-element-button" href="https://www.quantum-si.com/resources/tech-notes/platinum-next-generation-protein-sequencing-advanced-data-analysis-technical-note/">Download the Tech Note</a></p> </div> </li> <li class="accordion-item" data-accordion-item> <a href="#" class="accordion-title"> Next-Generation Protein Sequencing™: Interrogating Proteins with Single-molecule Amino Acid Resolution on Platinum® – WEBINARS</a> <div class="accordion-content" data-tab-content> <p>Proteins are the workhorses of cells and provide vital insights to cell health and disease function. Immunoassays and mass spectrometry are well established methods for studying proteins and have led to important discoveries in human health and disease. However, these techniques either lack single-molecule resolution to interrogate each individual amino acid residue or require a large investment in equipment and lab space, driving the need for a simple benchtop solution with single-molecule resolution for protein identification and interrogation.</p> <p>In this webinar, we will explore how next-generation protein sequencing on Platinum works and how it can be used to interrogate proteins with single-molecular amino acid resolution. This new technology utilizes semiconductor chip technology and fluorescently labeled n-terminal amino acid (NAA) recognizers to identify individual amino acids in a protein. The binding kinetics and order of the NAA recognizer signal results in a unique kinetic signature for each amino acid. Aminopeptidases then cleave the n-terminus and expose the next amino acid for binding. This process repeats until each peptide is sequenced.</p> <p>We will demonstrate how this technology can be used with traditional protein workflows that isolate proteins of interest and interrogate their sequences with single-molecule resolution. Finally, we will discuss the scalability of this technology for advancing our understanding of proteins and offering insights to human health and disease.</p> <div class="key-learning"> <p><strong>Learning Objectives:</strong></p> <ul> <li>Explore how next-generation protein sequencing works to interrogate amino acid residues</li> <li>Understand how next-generation protein sequencing can be used with other lab methods to understand protein biology</li> <li>Learn how next-generation protein sequencing can be used to detect amino acid variants with single-molecule resolution</li> </ul> </div> <p><strong>Speakers:</strong> Ben Moree, PhD, QSI</p> <p><strong>Date:</strong> December 7, 2023</p> <p><a class="wp-block-button__link has-black-color has-text-color wp-element-button" href="/resources/webinars/next-generation-protein-sequencing-interrogating-proteins-with-single-molecule-amino-acid-resolution-on-platinum/">Watch Now</a></p> </div> </li> <li class="accordion-item" data-accordion-item> <a href="#" class="accordion-title">Next-Generation Protein Sequencing™ Advances Variant Identification — WHITEPAPERS</a> <div class="accordion-content" data-tab-content> <p>In their quest to fully understand the proteome, researchers face an identification challenge: Distinguishing individual proteins among the 20,000-plus proteins and over 1 million proteoforms in human cells. Now a benchtop sequencer provides easy access to the analytical resolution needed to continue mapping protein variation.</p> <p>Platinum<sup>®</sup>, the Next-Generation Protein Sequencing™ platform, provides unambiguous amino acid detection at single molecule resolution. Learn how it complements existing protein identification techniques, such as mass spectrometry and immunoassays, while providing deeper insights with unprecedented accessibility.</p> <p><a class="wp-block-button__link has-black-color has-text-color wp-element-button" href="https://www.quantum-si.com/resources/whitepapers/next-generation-protein-sequencing-advances-variant-identification/">Download Whitepaper</a></p> </div> </li> <li class="accordion-item" data-accordion-item> <a href="#" class="accordion-title">Beyond the Genome: Unraveling Protein Variability with Quantum-Si’s Next-generation Protein Sequencing™ Technology — POSTER</a> <div class="accordion-content" data-tab-content> <p>Protein sequencing is a groundbreaking advancement in proteomics that augments genomics and transcriptomics research by providing crucial insights into the functional proteins encoded by the genome. Protein sequencing offers a more complete understanding of cellular processes and disease mechanisms by detecting changes at the protein level, such as post-translational modifications (PTMs), which cannot be captured by genomics data alone. Next-Generation Protein Sequencing™ (NGPS) on Platinum® enables researchers to identify and characterize proteins with single-molecule resolution in a simple workflow and on a benchtop instrument.</p> <p><a class="wp-block-button__link has-black-color has-text-color wp-element-button" href="https://www.quantum-si.com/resources/posters/beyond-the-genome-unraveling-protein-variability-with-quantum-sis-next-generation-protein-sequencing-technology-2/">Download Poster</a></p> </div> </li> </ul> </div> </div> </section> </div> </section> <div class="footer-bar"><p>RESEARCH USE ONLY. 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