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ul.mfn-megamenu > li.mfn-megamenu-cols-4{width:25%}#Top_bar .menu > li > ul.mfn-megamenu > li.mfn-megamenu-cols-5{width:20%}#Top_bar .menu > li > ul.mfn-megamenu > li.mfn-megamenu-cols-6{width:16.66%}#Top_bar .menu > li > ul.mfn-megamenu > li > ul{display:block!important;position:inherit;left:auto;top:auto;border-width:0 1px 0 0}#Top_bar .menu > li > ul.mfn-megamenu > li:last-child > ul{border:0}#Top_bar .menu > li > ul.mfn-megamenu > li > ul li{width:auto}#Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title{text-transform:uppercase;font-weight:400;background:none}#Top_bar .menu > li > ul.mfn-megamenu a .menu-arrow{display:none}.menuo-right #Top_bar .menu > li > ul.mfn-megamenu{left:0;width:98%!important;margin:0 1%;padding:20px 0}.menuo-right #Top_bar .menu > li > ul.mfn-megamenu-bg{box-sizing:border-box}#Top_bar .menu > li > ul.mfn-megamenu-bg{padding:20px 166px 20px 20px;background-repeat:no-repeat;background-position:right bottom}.rtl #Top_bar .menu > li > 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ul{width:100%;float:left}.header-simple #Top_bar #menu ul li{width:100%;padding-bottom:0;border-right:0;position:relative}.header-simple #Top_bar #menu ul li a{padding:0 20px;margin:0;display:block;height:auto;line-height:normal;border:none}.header-simple #Top_bar #menu ul li a:not(.menu-toggle):after{display:none}.header-simple #Top_bar #menu ul li a span{border:none;line-height:44px;display:inline;padding:0}.header-simple #Top_bar #menu ul li.submenu .menu-toggle{display:block;position:absolute;right:0;top:0;width:44px;height:44px;line-height:44px;font-size:30px;font-weight:300;text-align:center;cursor:pointer;color:#444;opacity:0.33;transform:unset}.header-simple #Top_bar #menu ul li.submenu .menu-toggle:after{content:"+";position:static}.header-simple #Top_bar #menu ul li.hover > .menu-toggle:after{content:"-"}.header-simple #Top_bar #menu ul li.hover a{border-bottom:0}.header-simple #Top_bar #menu ul.mfn-megamenu li .menu-toggle{display:none}.header-simple #Top_bar #menu ul li ul{position:relative!important;left:0!important;top:0;padding:0;margin:0!important;width:auto!important;background-image:none}.header-simple #Top_bar #menu ul li ul li{width:100%!important;display:block;padding:0}.header-simple #Top_bar #menu ul li ul li a{padding:0 20px 0 30px}.header-simple #Top_bar #menu ul li ul li a .menu-arrow{display:none}.header-simple #Top_bar #menu ul li ul li a span{padding:0}.header-simple #Top_bar #menu ul li ul li a span:after{display:none!important}.header-simple #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title{text-transform:uppercase;font-weight:400}.header-simple #Top_bar .menu > li > ul.mfn-megamenu > li > ul{display:block!important;position:inherit;left:auto;top:auto}.header-simple #Top_bar #menu ul li ul li ul{border-left:0!important;padding:0;top:0}.header-simple #Top_bar #menu ul li ul li ul li a{padding:0 20px 0 40px}.rtl.header-simple #Top_bar #menu{left:1px;right:auto}.rtl.header-simple #Top_bar 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li{margin:0}.menu-highlight.header-simple #Top_bar #menu ul li > a,.menu-highlight.header-creative #Top_bar #menu ul li > a{-webkit-border-radius:0;border-radius:0}.menu-highlight:not(.header-fixed):not(.header-simple) #Top_bar.is-sticky .menu > li > a{margin:10px 0!important;padding:5px 0!important}.menu-highlight:not(.header-fixed):not(.header-simple) #Top_bar.is-sticky .menu > li > a span{line-height:30px!important}.header-modern.menu-highlight.menuo-right .menu_wrapper{margin-right:20px}.menu-line-below #Top_bar .menu > li > a:not(.menu-toggle):after{top:auto;bottom:-4px}.menu-line-below #Top_bar.is-sticky .menu > li > a:not(.menu-toggle):after{top:auto;bottom:-4px}.menu-line-below-80 #Top_bar:not(.is-sticky) .menu > li > a:not(.menu-toggle):after{height:4px;left:10%;top:50%;margin-top:20px;width:80%}.menu-line-below-80-1 #Top_bar:not(.is-sticky) .menu > li > a:not(.menu-toggle):after{height:1px;left:10%;top:50%;margin-top:20px;width:80%}.menu-link-color #Top_bar .menu > li > a:not(.menu-toggle):after{display:none!important}.menu-arrow-top #Top_bar .menu > li > a:after{background:none repeat scroll 0 0 rgba(0,0,0,0)!important;border-color:#ccc transparent transparent;border-style:solid;border-width:7px 7px 0;display:block;height:0;left:50%;margin-left:-7px;top:0!important;width:0}.menu-arrow-top #Top_bar.is-sticky .menu > li > a:after{top:0!important}.menu-arrow-bottom #Top_bar .menu > li > a:after{background:none!important;border-color:transparent transparent #ccc;border-style:solid;border-width:0 7px 7px;display:block;height:0;left:50%;margin-left:-7px;top:auto;bottom:0;width:0}.menu-arrow-bottom #Top_bar.is-sticky .menu > li > a:after{top:auto;bottom:0}.menuo-no-borders #Top_bar .menu > li > a span{border-width:0!important}.menuo-no-borders #Header_creative #Top_bar .menu > li > a span{border-bottom-width:0}.menuo-no-borders.header-plain #Top_bar a#header_cart,.menuo-no-borders.header-plain #Top_bar a#search_button,.menuo-no-borders.header-plain #Top_bar 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#Footer.is-sticky{padding-left:0;padding-right:50px}.header-rtl.header-open.footer-fixed #Footer,.header-rtl.header-open.footer-sliding #Footer,.header-rtl.header-creative.footer-stick #Footer.is-sticky{padding-right:250px}#Header_creative{background-color:#fff;position:fixed;width:250px;height:100%;left:-200px;top:0;z-index:9002;-webkit-box-shadow:2px 0 4px 2px rgba(0,0,0,.15);box-shadow:2px 0 4px 2px rgba(0,0,0,.15)}#Header_creative .container{width:100%}#Header_creative .creative-wrapper{opacity:0;margin-right:50px}#Header_creative a.creative-menu-toggle{display:block;width:34px;height:34px;line-height:34px;font-size:22px;text-align:center;position:absolute;top:10px;right:8px;border-radius:3px}.admin-bar #Header_creative a.creative-menu-toggle{top:42px}#Header_creative #Top_bar{position:static;width:100%}#Header_creative #Top_bar .top_bar_left{width:100%!important;float:none}#Header_creative #Top_bar .logo{float:none;text-align:center;margin:15px 0}#Header_creative #Top_bar #menu{background-color:transparent}#Header_creative #Top_bar .menu_wrapper{float:none;margin:0 0 30px}#Header_creative #Top_bar .menu > li{width:100%;float:none;position:relative}#Header_creative #Top_bar .menu > li > a{padding:0;text-align:center}#Header_creative #Top_bar .menu > li > a:after{display:none}#Header_creative #Top_bar .menu > li > a span{border-right:0;border-bottom-width:1px;line-height:38px}#Header_creative #Top_bar .menu li ul{left:100%;right:auto;top:0;box-shadow:2px 2px 2px 0 rgba(0,0,0,0.03);-webkit-box-shadow:2px 2px 2px 0 rgba(0,0,0,0.03)}#Header_creative #Top_bar .menu > li > ul.mfn-megamenu{margin:0;width:700px!important}#Header_creative #Top_bar .menu > li > ul.mfn-megamenu > li > ul{left:0}#Header_creative #Top_bar .menu li ul li a{padding-top:9px;padding-bottom:8px}#Header_creative #Top_bar .menu li ul li ul{top:0}#Header_creative #Top_bar .menu > li > a span.description{display:block;font-size:13px;line-height:28px!important;clear:both}.menuo-arrows #Top_bar .menu > li.submenu > a > span:after{content:unset!important}#Header_creative #Top_bar .top_bar_right{width:100%!important;float:left;height:auto;margin-bottom:35px;text-align:center;padding:0 20px;top:0;-webkit-box-sizing:border-box;-moz-box-sizing:border-box;box-sizing:border-box}#Header_creative #Top_bar .top_bar_right:before{content:none}#Header_creative #Top_bar .top_bar_right .top_bar_right_wrapper{flex-wrap:wrap;justify-content:center}#Header_creative #Top_bar .top_bar_right .top-bar-right-icon,#Header_creative #Top_bar .top_bar_right .wpml-languages,#Header_creative #Top_bar .top_bar_right .top-bar-right-button,#Header_creative #Top_bar .top_bar_right .top-bar-right-input{min-height:30px;margin:5px}#Header_creative #Top_bar .search_wrapper{left:100%;top:auto}#Header_creative #Top_bar .banner_wrapper{display:block;text-align:center}#Header_creative #Top_bar .banner_wrapper img{max-width:100%;height:auto;display:inline-block}#Header_creative #Action_bar{display:none;position:absolute;bottom:0;top:auto;clear:both;padding:0 20px;box-sizing:border-box}#Header_creative #Action_bar .contact_details{width:100%;text-align:center;margin-bottom:20px}#Header_creative #Action_bar .contact_details li{padding:0}#Header_creative #Action_bar .social{float:none;text-align:center;padding:5px 0 15px}#Header_creative #Action_bar .social li{margin-bottom:2px}#Header_creative #Action_bar .social-menu{float:none;text-align:center}#Header_creative #Action_bar .social-menu li{border-color:rgba(0,0,0,.1)}#Header_creative .social li a{color:rgba(0,0,0,.5)}#Header_creative .social li a:hover{color:#000}#Header_creative .creative-social{position:absolute;bottom:10px;right:0;width:50px}#Header_creative .creative-social li{display:block;float:none;width:100%;text-align:center;margin-bottom:5px}.header-creative .fixed-nav.fixed-nav-prev{margin-left:50px}.header-creative.header-open .fixed-nav.fixed-nav-prev{margin-left:250px}.menuo-last #Header_creative #Top_bar .menu li.last ul{top:auto;bottom:0}.header-open #Header_creative{left:0}.header-open #Header_creative .creative-wrapper{opacity:1;margin:0!important}.header-open #Header_creative .creative-menu-toggle,.header-open #Header_creative .creative-social{display:none}.header-open #Header_creative #Action_bar{display:block}body.header-rtl.header-creative{padding-left:0;padding-right:50px}.header-rtl #Header_creative{left:auto;right:-200px}.header-rtl #Header_creative .creative-wrapper{margin-left:50px;margin-right:0}.header-rtl #Header_creative a.creative-menu-toggle{left:8px;right:auto}.header-rtl #Header_creative .creative-social{left:0;right:auto}.header-rtl #Footer #back_to_top.sticky{right:125px}.header-rtl #popup_contact{right:70px}.header-rtl #Header_creative #Top_bar .menu li ul{left:auto;right:100%}.header-rtl #Header_creative #Top_bar .search_wrapper{left:auto;right:100%}.header-rtl .fixed-nav.fixed-nav-prev{margin-left:0!important}.header-rtl .fixed-nav.fixed-nav-next{margin-right:50px}body.header-rtl.header-creative.header-open{padding-left:0;padding-right:250px!important}.header-rtl.header-open #Header_creative{left:auto;right:0}.header-rtl.header-open #Footer #back_to_top.sticky{right:325px}.header-rtl.header-open #popup_contact{right:270px}.header-rtl.header-open .fixed-nav.fixed-nav-next{margin-right:250px}#Header_creative.active{left:-1px}.header-rtl #Header_creative.active{left:auto;right:-1px}#Header_creative.active .creative-wrapper{opacity:1;margin:0}.header-creative .vc_row[data-vc-full-width]{padding-left:50px}.header-creative.header-open .vc_row[data-vc-full-width]{padding-left:250px}.header-open .vc_parallax .vc_parallax-inner{left:auto;width:calc(100% - 250px)}.header-open.header-rtl .vc_parallax .vc_parallax-inner{left:0;right:auto}#Header_creative.scroll{height:100%;overflow-y:auto}#Header_creative.scroll:not(.dropdown) .menu li ul{display:none!important}#Header_creative.scroll #Action_bar{position:static}#Header_creative.dropdown{outline:none}#Header_creative.dropdown #Top_bar .menu_wrapper{float:left;width:100%}#Header_creative.dropdown #Top_bar #menu ul li{position:relative;float:left}#Header_creative.dropdown #Top_bar #menu ul li a:not(.menu-toggle):after{display:none}#Header_creative.dropdown #Top_bar #menu ul li a span{line-height:38px;padding:0}#Header_creative.dropdown #Top_bar #menu ul li.submenu .menu-toggle{display:block;position:absolute;right:0;top:0;width:38px;height:38px;line-height:38px;font-size:26px;font-weight:300;text-align:center;cursor:pointer;color:#444;opacity:0.33;z-index:203}#Header_creative.dropdown #Top_bar #menu ul li.submenu .menu-toggle:after{content:"+";position:static}#Header_creative.dropdown #Top_bar #menu ul li.hover > .menu-toggle:after{content:"-"}#Header_creative.dropdown #Top_bar #menu ul.sub-menu li:not(:last-of-type) a{border-bottom:0}#Header_creative.dropdown #Top_bar #menu ul.mfn-megamenu li .menu-toggle{display:none}#Header_creative.dropdown #Top_bar #menu ul li ul{position:relative!important;left:0!important;top:0;padding:0;margin-left:0!important;width:auto!important;background-image:none}#Header_creative.dropdown #Top_bar #menu ul li ul li{width:100%!important}#Header_creative.dropdown #Top_bar #menu ul li ul li a{padding:0 10px;text-align:center}#Header_creative.dropdown #Top_bar #menu ul li ul li a .menu-arrow{display:none}#Header_creative.dropdown #Top_bar #menu ul li ul li a span{padding:0}#Header_creative.dropdown #Top_bar #menu ul li ul li a span:after{display:none!important}#Header_creative.dropdown #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title{text-transform:uppercase;font-weight:400}#Header_creative.dropdown #Top_bar .menu > li > ul.mfn-megamenu > li > ul{display:block!important;position:inherit;left:auto;top:auto}#Header_creative.dropdown #Top_bar #menu ul li ul li ul{border-left:0!important;padding:0;top:0}#Header_creative{transition:left .5s ease-in-out,right .5s ease-in-out}#Header_creative .creative-wrapper{transition:opacity .5s ease-in-out,margin 0s ease-in-out .5s}#Header_creative.active .creative-wrapper{transition:opacity .5s ease-in-out,margin 0s ease-in-out}}@media only screen and (min-width:1240px){#Top_bar.is-sticky{position:fixed!important;width:100%;left:0;top:-60px;height:60px;z-index:701;background:#fff;opacity:.97;-webkit-box-shadow:0 2px 5px 0 rgba(0,0,0,0.1);-moz-box-shadow:0 2px 5px 0 rgba(0,0,0,0.1);box-shadow:0 2px 5px 0 rgba(0,0,0,0.1)}.layout-boxed.header-boxed #Top_bar.is-sticky{left:50%;-webkit-transform:translateX(-50%);transform:translateX(-50%)}#Top_bar.is-sticky .top_bar_left,#Top_bar.is-sticky .top_bar_right,#Top_bar.is-sticky .top_bar_right:before{background:none;box-shadow:unset}#Top_bar.is-sticky .logo{width:auto;margin:0 30px 0 20px;padding:0}#Top_bar.is-sticky #logo,#Top_bar.is-sticky .custom-logo-link{padding:5px 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#Top_bar:not(.is-sticky){background-color:rgba(255,255,255,0.8)}}@media only screen and ( max-width:767px ){#Top_bar{background-color:#ffffff !important}#Action_bar{background-color:#007dc5 !important}#Action_bar .contact_details{color:#222222}#Action_bar .contact_details a{color:#0095eb}#Action_bar .contact_details a:hover{color:#007cc3}#Action_bar .social li a,#Action_bar .social-menu a{color:#bbbbbb!important}#Action_bar .social li a:hover,#Action_bar .social-menu a:hover{color:#777777!important}} form input.display-none{display:none!important} </style> <link rel='stylesheet' id='style-css' href='https://www.wyatt.com/wp-content/themes/betheme-child/style.css?ver=6.4.5' type='text/css' media='all' /> <style id='mfn-custom-inline-css' type='text/css'> @supports (-ms-ime-align: auto) { } span {font-family:"Open Sans", Arial, Tahoma, sans-serif !important;} @media only screen and (min-width: 1240px) { .header-classic #Header .top_bar_left {width:1306px;} #Top_bar .menu > li > a {padding:15px 5px;} #Top_bar.is-sticky .menu_wrapper .menu > li > a {padding:15px 5px;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu{ padding-top:0px; padding-bottom:0px; width:92.5%!important; margin:0px 3%;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu .container {display:block;} /** Added 121024 **/ h1 { line-height: 44px !important; } .h2-underline {border-bottom: thick solid #ffb600; padding-bottom: 15px;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu::before {content:' '; background:#fff; position:absolute; width:100vw; height:100%; margin-left: -50vw; left: 50%; } .mm-vertical #Top_bar .menu > li > .menu-overlap {z-index:1;background:rgba(0,0,0,0.4); position:absolute; width:100vw; height:100vh; margin-left: -50vw; left: 50%; cursor:hand; cursor:pointer;} .mm-vertical #Top_bar .menu > li.not-active a{color:#444444;} .mm-vertical #Top_bar .menu > li.not-active a::after {opacity:0;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title, .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title:hover {padding:5px 0px; background:transparent; color:#444444; text-transform:unset;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title:hover span {text-decoration:none ;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu ul {background:transparent; } .mm-vertical #Top_bar .menu > li >ul.mfn-megamenu ul a {color:#007dc5; } .mm-vertical #Top_bar .menu > li >ul.mfn-megamenu ul a:hover {background:transparent;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li a {padding:5px 0px;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li a:hover {text-decoration:underline;} .mm-vertical #Top_bar .menu > li > ul {padding:20px 20px 20px 2px;} .mm-vertical #Top_bar .menu > li > ul a {padding:5px; border:0px; color:#007dc5;} .mm-vertical #Top_bar .menu > li > ul a:hover {background:transparent; } .mm-vertical #Top_bar .menu > li > ul a:hover span {text-decoration:underline ;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li {padding-top:20px; padding-bottom:25px; border-right: 0px solid rgba(0, 0, 0, 0.05);} /*for parent title in sbmenu*/ .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:first-child {display:none; width:auto; padding-bottom:0px;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:first-child h3 {padding-top:20px; line-height:30px; border-bottom:1px solid #ccc; font-weight:600;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:first-child h3 a{color:#444444;} /*for contact submenu*/ .mm-vertical #Top_bar .menu > li#menu-item-2437 li.mfn-megamenu-cols-2 li {} /*menu button css*/ .mm-vertical #Top_bar .menu > li#menu-item-5221 a span {background:#007dc5; color:#fff; border-radius:6px; line-height:40px; margin-top:8px; margin-left:20px;} .mm-vertical #Top_bar .menu > li#menu-item-5221 a:after {display:none;} #Top_bar.is-sticky .menu > li#menu-item-5221 > a, #Top_bar.is-sticky .menu > li#menu-item-5221 > a span {line-height:30px; margin-top:0px;} .mm-vertical #Top_bar li#menu-item-6152 a {color:#000 !important; padding-top:0px !important; white-space:nowrap; color: #007dc5 !important; font-weight: 400;} /*set width of menu item*/ .mm-vertical #Top_bar li#menu-item-2341 {width:343px; padding-left: 80px;} .mm-vertical #Top_bar li#menu-item-2348 {width:278px;} .mm-vertical #Top_bar li#menu-item-2355 {width:288px;} .mm-vertical #Top_bar li#menu-item-2363 {width:240px;} .mm-vertical #Top_bar li#menu-item-2369 {width:541px; padding-left:70px;} .mm-vertical #Top_bar li#menu-item-2379 {width:340px;} .mm-vertical #Top_bar li#menu-item-2384 {width:280px;} .mm-vertical #Top_bar li#menu-item-2391 {width:350px; padding-left:80px;} .mm-vertical #Top_bar li#menu-item-2395 {width:310px;} .mm-vertical #Top_bar li#menu-item-2403 {width:310px;} .mm-vertical #Top_bar li#menu-item-2408 {width:210px;} .mm-vertical #Top_bar li#menu-item-5918 {width:487px; padding-left:115px;} .mm-vertical #Top_bar li#menu-item-5919 {width:387px;} .mm-vertical #Top_bar li#menu-item-5920 {width:280px;} .mm-vertical #Top_bar li#menu-item-2427 {width:700px; padding-left:300px;} .mm-vertical #Top_bar li#menu-item-5235 {width:487px; padding-left:115px;} .mm-vertical #Top_bar li#menu-item-5765 {width:310px;} .mm-vertical #Top_bar li#menu-item-26131 {width:387px;} .mm-vertical #Top_bar li#menu-item-15082 {width:700px; padding-left:300px;} .mm-vertical #Top_bar li#menu-item-15044 {width:397px;} } @media only screen and (max-width: 1239px) { #menu > ul > li > a, a.action_button, #overlay-menu ul li a { font-size: 15px; font-weight: 400; letter-spacing: 1px;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:first-child {display:none; width:auto; padding-bottom:0px;} .mm-vertical #Top_bar #menu ul li ul li a {font-size:16px;} .mm-vertical #Top_bar #menu ul li ul li ul li a {font-size:15px;} } /* Header */ .header-classic #Top_bar { border-bottom: 0px solid #e1e1e1;} .header-classic:not(.home) #Content { border-top: 0px solid #e1e1e1; } .header-classic.home .mfn-rev-slider { border-top: 1px solid #e1e1e1; } /*Action Bar*/ #Action_bar a {color:#fff;} /* Widget */ .widget-area:before { display: none; } .aside_left .widget-area { border: 0; } /* Icon box */ .icon_box.has_border { background: #fff; border: 1px solid #e1e1e1; padding: 40px 10%; } .icon_box.no_border {background: #fff; border:0px; padding: 40px 10%;} .icon_box.has_border:after {border:0px} /* Offer box */ .offer_box { background-color: #252525; padding: 20px 20px 5px; text-align: center; } .offer_box .offer_box_list { border-width: 1px 1px 0 1px; border-style: solid; border-color: #929292; font-weight: 700; font-size: 16px; letter-spacing: 2px; margin-bottom: 20px; } .offer_box .offer_box_list a { display: block; color: #fff; border-bottom: 1px solid #929292; padding: 18px 15px; word-wrap: break-word; } /* Footer */ /*#Footer { border-top: 1px solid #e1e1e1; }*/ #Footer .widget > h4 { font-size: 18px; font-weight: 300; margin-bottom: 20px; } #Footer .footer_copy { background: #465158; border-top: 0; } .before-footer {background: #f9f9f9;} #Footer .footer_copy .social { display: none; } /**/ .top-widgets-container {float:right} .top-widgets-container .widget {padding-bottom:0px; margin-bottom:0px; float:right;margin-top:0px;} .top-widgets-container .widget ul.menu{list-style:none; padding:0px;} .top-widgets-container .widget ul.menu li {float:left; padding:12px 0px;} .top-widgets-container .widget ul.menu li a{padding:0px 20px; border-right:1px solid #ccc; line-height:15px;} .top-widgets-container .widget ul.menu li:last-child a{border-right:0px;} .top-widgets-container .widget_search .icon-search-fine {font-size:24px; line-height:40px;} .top-widgets-container .widget_search input[type="text"] {width:82%; float:right; padding:5px 10px 5px 5px; border:0px; margin-top:7px; height:30px;min-height:30px;} #menu-top-navigation .cart a {padding:0px 20px; } #menu-top-navigation .cart a:before {font-family: "mfn-icons"; content:'\e82d'; float:left; padding-right:10px; font-size:26px; color:#fff; text-indent:0;} .mobilecart {display:none; width:30px; float:right; margin-top:11px;} .mobilecart a { padding:0px; border:0px;} .mobilecart a:before {font-family: "mfn-icons"; content:'\e82d'; float:left; left:15px; font-size:26px; color:#fff; text-indent:0;} @media only screen and (min-width:320px) and (max-width:767px) { .top-widgets-container .widget {float:none;} .top-widgets-container .widget.widget_nav_menu {max-width:245px; margin:0px auto; clear:both;} .top-widgets-container .widget ul.menu li a {padding:0px 15px;} #menu-top-navigation .cart.menu-item-2449 {display:none;} #menu-top-navigation .cart a {padding:0px 10px;} .widget_archive ul li:after, .widget_nav_menu ul li:after {display:none;} .widget:after {display:none;} .top-widgets-container {float:none; margin:0px auto;} .top-widgets-container .widget_search input[type="text"] {width:80%;} .mobilecart {display:block;} .top-widgets-container .widget_search {width:254px; overflow:hidden;padding-bottom:20px; margin:0px auto;} .top-widgets-container .widget_search .searchform{width:210px; float:left;} } .icon-100 .image_wrapper img {width:150px; height:150px;} .down-heading, .heading {padding-left:17px;} @media only screen and (min-width:320px) and (max-width:767px) { .down-heading, .heading {padding:0px; text-align:center;} } .ui-tabs .ui-tabs-nav li {border-width:0px;} .page-id-2602 .ui-tabs .ui-tabs-nav li a {padding:14px 28px !important;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav li {border:0px; padding:5px 0px;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav li a {background-image:none; font-size:100%; color:#2991d6; padding:5px 10px 5px 20px !important;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav li a:hover {text-decoration:underline;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active a {color:#000; border-left:3px solid #2991d6; border-radius:0px !important; padding:5px 10px 5px 17px !important;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav {width:23%; border:0px !important;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-panel {width:76.7%; border:0px !important; padding-top:5px;} @media only screen and (min-width:768px) and (max-width:1239px) { .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav li a {font-size:100%;} } @media only screen and (min-width:320px) and (max-width:767px) { .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav {width:100%;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-panel {width:100%; padding-top:15px;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav li a {-webkit-box-shadow:none;-moz-box-shadow:none;box-shadow:none;} } .ui-tabs .ui-tabs-nav li h3 {margin:0px; padding:0px;} .ui-tabs .ui-tabs-nav li h3 a { text-decoration: none; display: block; padding: 14px 30px !important; font-size: 100%; font-weight:initial; } .ui-tabs .ui-tabs-panel .icon_box {padding-bottom:2px;} .ui-tabs .ui-tabs-panel .column.one-fourth {width:25%;} .ui-tabs .ui-tabs-panel .column.one-second, .ui-tabs .ui-tabs-panel .column.one-fourth, .ui-tabs .ui-tabs-panel .column.one-third, .ui-tabs .ui-tabs-panel .column.two-third{margin-left:0px; margin-right:0px;} @media only screen and (min-width: 960px) and (max-width: 1239px) { .ui-tabs .ui-tabs-nav li h3 a {font-size:100%; padding:10px 20px !important;} } @media only screen and (min-width: 768px) and (max-width: 959px) { .ui-tabs .ui-tabs-nav li h3 a {font-size:100%; padding:5px 10px !important;} } /* Make Nav Subheadings unclickable */ .unclickable > a:hover { cursor: default;} .wp-caption-text { background: transparent; color: #075c97; font-size:90%;} .ls-wrapper h3 a {color: #075c97;} .column_sidebar_widget {float:none;} /*app notes*/ ul.clients.appnotes .client_wrapper {text-align:left; height:auto !important; line-height:auto !important; overflow:hidden;} ul.clients.appnotes li:nth-child(2n+1) {clear:both;} ul.clients.appnotes .client_wrapper img { position:relative; left:auto !important; top: auto !important; float:left; -webkit-transform: none!important; -moz-transform: none!important; transform: none!important; padding-right:20px; width:auto!important; } ul.clients.appnotes .client_wrapper h3 { line-height:20px; font-size:16px; letter-spacing:1px; padding-top:10px;} ul.clients.appnotes .client_wrapper a:hover {text-decoration:none;} @media only screen and (max-width: 640px) { ul.clients.appnotes li {width:100% !important; clear:both;} } .pager {padding-top:20px;} .pager .page-numbers {border:1px solid #ccc; padding:3px 5px;} .pager .prev.page-numbers, .pager .next.page-numbers {border:0px;} .alignleft {margin:3px 10px 10px 0px;} dl {clear:both;} .team.team_vertical img.scale-with-grid {width:100%;} .column_placeholder {margin-bottom:0px;} .icon-height img{max-height:50px;} .single .post-header {margin-left:0px; margin-right:0px;} .single .section-post-header .single-photo-wrapper.image {display:none;} .widget_mfn_menu ul li.menu-item-has-children > a::after {content: '\e868'; font-family: "mfn-icons"; right:2px; position:absolute; width:20px; height:15px; color:#ccc; } table th ul, table td ul {list-style-position:inside !important;} .sticky-white #Top_bar.is-sticky, .sticky-white #Top_bar.is-sticky #menu, #Top_bar.is-sticky {background:#fff; opacity:1;} /*Webinars latest posts*/ .parent-pageid-3663 .Latest_news ul li {margin-top:15px; margin-bottom:15px;} .parent-pageid-3663 .Latest_news ul li.has-post-thumbnail .desc {margin-left: 70px; width: 95%;} .parent-pageid-3663 .Latest_news ul li .photo {width:70px; border-right:0px; text-align:center; display:table;} .parent-pageid-3663 .Latest_news ul li .photo a {display:table-cell; vertical-align:middle;} .parent-pageid-3663 .Latest_news ul li .photo img {max-width:50px !important; vertical-align:middle;} .parent-pageid-3663 .Latest_news ul li .desc {border-left:3px solid #000; padding-top:0px; padding-bottom:0px; display:table-cell; vertical-align:middle;} .parent-pageid-3663 .Latest_news ul li.category-webinars .desc h5 a{color:#007dc5;} .parent-pageid-3663 .Latest_news ul li .desc_footer .date {display:none;} .parent-pageid-3663 .Latest_news ul li .desc_footer .icon-comment-empty-fa {display:none} .parent-pageid-3663 .Latest_news ul li .desc_footer .post-comments {display:none;} .parent-pageid-3663 .Latest_news ul li .desc_footer .button-love {display:none;} .parent-pageid-3663 .Latest_news ul li .desc .post-excerpt {margin-top:0px;} .parent-pageid-3663 .Latest_news ul li .desc .post-excerpt p{margin-bottom:0px; line-height:20px;} /*Upcoming Live Webinars*/ .page-id-2653 .Latest_news ul li {margin-top:15px; margin-bottom:15px;} .page-id-2653 .Latest_news ul li.has-post-thumbnail .desc {margin-left: 70px; width: 95%;} .page-id-2653 .Latest_news ul li .photo {width:70px; border-right:0px; text-align:center; display:table;} .page-id-2653 .Latest_news ul li .photo a {display:table-cell; vertical-align:middle;} .page-id-2653 .Latest_news ul li .photo img {max-width:50px !important; vertical-align:middle;} .page-id-2653 .Latest_news ul li .desc {border-left:3px solid #000; padding-top:0px; padding-bottom:0px; display:table-cell; vertical-align:middle;} .page-id-2653 .Latest_news ul li.category-webinars .desc h5 a{color:#007dc5;} .page-id-2653 .Latest_news ul li .desc_footer .date {display:none;} .page-id-2653 .Latest_news ul li .desc_footer .icon-comment-empty-fa {display:none} .page-id-2653 .Latest_news ul li .desc_footer .post-comments {display:none;} .page-id-2653 .Latest_news ul li .desc_footer .button-love {display:none;} .page-id-2653 .Latest_news ul li .desc .post-excerpt {margin-top:0px;} .page-id-2653 .Latest_news ul li .desc .post-excerpt p{margin-bottom:0px; line-height:20px;} /*Newsletter Archive*/ .page-id-3661 .Latest_news ul li {margin-top:15px; margin-bottom:15px;} .page-id-3661 .Latest_news ul li.has-post-thumbnail .desc {margin-left: 70px; width: 95%;} .page-id-3661 .Latest_news ul li .photo {width:70px; border-right:0px; text-align:center; display:table;} .page-id-3661 .Latest_news ul li .photo a {display:table-cell; vertical-align:middle;} .page-id-3661 .Latest_news ul li .photo img {max-width:50px !important; vertical-align:middle;} .page-id-3661 .Latest_news ul li .desc {border-left:3px solid #000; padding-top:0px; padding-bottom:0px; display:table-cell; vertical-align:middle;} .page-id-3661 .Latest_news ul li.category-newsletter-archive .desc h5 a{color:#007dc5;} .page-id-3661 .Latest_news ul li .desc_footer .date {display:none;} .page-id-3661 .Latest_news ul li .desc_footer .icon-comment-empty-fa {display:none} .page-id-3661 .Latest_news ul li .desc_footer .post-comments {display:none;} .page-id-3661 .Latest_news ul li .desc_footer .button-love {display:none;} .page-id-3661 .Latest_news ul li .desc .post-excerpt {margin-top:0px;} .page-id-3661 .Latest_news ul li .desc .post-excerpt p{margin-bottom:0px; line-height:20px;} /*Ask the Expert*/ .page-id-5348 .Latest_news ul li {margin-top:15px; margin-bottom:15px;} .page-id-5348 .Latest_news ul li.has-post-thumbnail .desc {margin-left: 70px; width: 95%;} .page-id-5348 .Latest_news ul li .photo {width:70px; border-right:0px; text-align:center; display:table;} .page-id-5348 .Latest_news ul li .photo a {display:table-cell; vertical-align:middle;} .page-id-5348 .Latest_news ul li .photo img {max-width:50px !important; vertical-align:middle;} .page-id-5348 .Latest_news ul li .desc {border-left:3px solid #000; padding-top:0px; padding-bottom:0px; display:table-cell; vertical-align:middle;} .page-id-5348 .Latest_news ul li .desc h5{margin-bottom:0px;} .page-id-5348 .Latest_news ul li.category-ask-the-expert .desc h5 a{color:#007dc5;} .page-id-5348 .Latest_news ul li .desc_footer {display:none;} .page-id-5348 .Latest_news ul li .desc_footer .date {display:none;} .page-id-5348 .Latest_news ul li .desc_footer .icon-comment-empty-fa {display:none} .page-id-5348 .Latest_news ul li .desc_footer .post-comments {display:none;} .page-id-5348 .Latest_news ul li .desc_footer .button-love {display:none;} .page-id-5348 .Latest_news ul li .desc .post-excerpt {margin-top:0px;} .page-id-5348 .Latest_news ul li .desc .post-excerpt p{margin-bottom:0px; font-weight:normal; line-height:20px;} /*accordion title as h3*/ .accordion .question .title h3 {margin-bottom:0px; } .accordion .question.active .title h3{color:#2991d6} /*column padding*/ .column, .columns {margin:0px 10px 40px;} .accordion .answer .one-second.column {width:47%;} .wrap .one-second.column {width:47%;} /*.column_column ul li {margin-bottom:2px;}*/ .single .post-header {margin-bottom:10px;} /* Appnote seach box*/ .widget_appnote_search_widget {clear:both; display:block; overflow:hidden;} .widget_appnote_search_widget .widget-title {display:inline-block; float:left; margin-right:15px; margin-top:5px;} .widget_appnote_search_widget .searchform {display:inline-block; float:left;} .widget_appnote_search_widget .searchform input[type=text] {float:left; margin:0px; min-width:350px; padding:7px 10px;} .widget_appnote_search_widget .searchform input[type=submit] {background:#0065a4; margin:0px; margin-left:15px; padding:8px 20px;} @media only screen and (min-width: 320px) and (max-width: 650px) { .widget_appnote_search_widget .searchform input[type=text] {min-width:240px;} } @media only screen and (min-width: 320px) and (max-width: 519px) { .widget_appnote_search_widget .searchform input[type=submit] {margin:0px; margin-top:15px;} } /*flat box*/ .flat_box .photo_wrapper .icon {display:none;} .flat_box .photo_wrapper img.photo {transform: translateX(0px)} .flat_box .desc_wrapper {margin-left:0px;} /*center images at user profile*/ .page-id-2504 .image_frame .image_wrapper {text-align:center} .page-id-2504.if-overlay .image_frame:hover .image_wrapper img, .page-id-2504.if-overlay .image_frame.hover .image_wrapper img {transform: scale(1);} .if-overlay .image_frame .image_wrapper .image_links {display:none;} /* Changes for ClickDimensions submit button */ a.button_theme, a.tp-button.button_theme, button, input[type="submit"], input[type="reset"], input[type="button"] { background-color: #0065a4 !important; color: #ffffff !important; font-family: inherit !important; /*padding:0px;*/ } /*isotope wrapper*/ .blog_wrapper.isotope_wrapper .post-item .post-footer {background:none;} .blog_wrapper.isotope_wrapper .post-item .post-footer .post-links{border:0px;} .blog_wrapper.isotope_wrapper .grid .post-photo-wrapper {border:0px;} /* product page*/ .page-id-2582 .ui-tabs-panel .team.team_vertical .image_frame {border:0px;} .page-id-2582 .ui-tabs-panel .team.team_vertical hr.hr_color {background:none;} .page-id-2582.if-overlay .ui-tabs-panel .team.team_vertical .image_frame:hover .image_wrapper img, .page-id-2582.if-overlay .ui-tabs-panel .team.team_vertical .image_frame.hover .image_wrapper img {-webkit-transform: scale(1); -moz-transform: scale(1); -o-transform: scale(1); transform: scale(1); } .page-id-2582 .ui-tabs-panel .one-third.column:nth-child(4n-3) {margin-left:10px; margin-right:17px; } .page-id-2582 .ui-tabs-panel .one-third.column:nth-child(4n-2) {margin-left:18px; margin-right:17px; } .page-id-2582 .ui-tabs-panel .one-third.column:nth-child(4n-1) {margin-left:18px; margin-right:10px; } .page-id-2582 .ui-tabs-panel .one-second.column:nth-child(odd) {margin-left:65px; margin-right:52px; } .page-id-2582 .ui-tabs-panel .one-second.column:nth-child(even) {margin-left:53px; margin-right:65px; } @media only screen and (min-width: 1301px) { .page-id-2582 .ui-tabs-panel .one-third.column {width:30.9%;} .page-id-2582 .ui-tabs-panel .one-second.column {width:40.2%;} } @media only screen and (min-width: 1240px) and (max-width: 1300px) { .page-id-2582 .ui-tabs-panel .one-third.column {width:30.7%;} .page-id-2582 .ui-tabs-panel .one-second.column {width:47.6%;} } @media only screen and (min-width: 960px) and (max-width: 1239px) { .page-id-2582 .ui-tabs-panel .one-third.column {width:29.9%;} .page-id-2582 .ui-tabs-panel .one-second.column {width:36.6%;} } @media only screen and (min-width: 768px) and (max-width: 959px) { .page-id-2582 .ui-tabs-panel .one-third.column {width:28.7%;} .page-id-2582 .ui-tabs-panel .one-second.column {width:38.9%;} } @media only screen and (min-width: 320px) and (max-width: 767px) { .page-id-2582 .ui-tabs-panel .one-third.column {margin-left:0px; margin-right:0px;} .page-id-2582 .ui-tabs-panel .one-second.column:nth-child(even), .page-id-2582 .ui-tabs-panel .one-second.column:nth-child(odd) {margin-left:0px; margin-right:0px;} } .uk-margin-small-right {vertical-align:middle; margin-top:-2px;} .page-id-2647 .ui-tabs .ui-tabs-panel .column.one-second {margin-bottom:0px;} .page-id-3641 .blog_wrapper .classic .post-photo-wrapper {border-color:transparent;} @media only screen and (min-width: 960px) { .page-id-3641 .blog_wrapper .classic .post-photo-wrapper {width:12%;} .page-id-3641 .blog_wrapper .classic .post-desc-wrapper {width:88%;} } @media only screen and (min-width: 768px) and (max-width: 959px) { .page-id-3641 .blog_wrapper .classic .post-photo-wrapper { width:25%} .page-id-3641 .blog_wrapper .classic .post-desc-wrapper {width:75%;} } @media only screen and (min-width: 768px) { .page-id-2640 .column.column_pricing_item {margin:0px 1% 40px;} } /* contact form 7 submit button*/ .wpcf7-form-control.wpcf7-submit {padding:10px 30px;} .wpcf7 .red {color:#990000;} .wpcf7 span.wpcf7-list-item {display:block; margin:0px;} .wpcf7 label {font-weight:400;} #lostusername {border:1px solid #ddd; padding:30px 20px 0px;} #lostusername .input {width:100%;} #lostusername .button {padding:10px 20px;} .ur-frontend-form button[type="submit"], .ur-frontend-form input[type="submit"] {float:none;} .page-id-2690.if-overlay .image_frame:hover .image_wrapper img, .page-id-2690.if-overlay .image_frame.hover .image_wrapper img {transform: scale(1);} .page-id-2690 .team .desc_wrapper hr {display:none;} .page-id-2690 .ui-tabs .ui-tabs-panel .column.one-second, .page-id-2690 .ui-tabs .ui-tabs-panel .column.one-fourth, .page-id-2690 .ui-tabs .ui-tabs-panel .column.one-third, .page-id-2690 .ui-tabs .ui-tabs-panel .column.two-third {margin-left:10px; margin-right:10px;} .page-id-2690 .ui-tabs .ui-tabs-panel .column.one-fourth {width:23.4%;} /* webinars seach box*/ .widget_webinars_search_widget {clear:both; display:block; overflow:hidden;} .widget_webinars_search_widget .widget-title {display:inline-block; float:left; margin-right:15px; margin-top:5px;} .widget_webinars_search_widget .searchform {display:inline-block; float:left;} .widget_webinars_search_widget .searchform input[type=text] {float:left; margin:0px; min-width:350px; padding:7px 10px;} .widget_webinars_search_widget .searchform input[type=submit] {background:#0065a4; margin:0px; margin-left:15px; padding:8px 20px;} @media only screen and (min-width: 320px) and (max-width: 650px) { .widget_webinars_search_widget .searchform input[type=text] {min-width:240px;} } @media only screen and (min-width: 320px) and (max-width: 519px) { .widget_webinars_search_widget .searchform input[type=submit] {margin:0px; margin-top:15px;} } /*Recent Webinars nav issue fix*/ .page-id-3665 li#menu-item-2421.current-menu-ancestor:not(.hover) a {color:#000000;} .page-id-3665 li#menu-item-2421.current-menu-ancestor:not(.hover) a:after {display:none;} /*login-in nav issue fix*/ .page-id-5451 li#menu-item-2390.current-menu-ancestor:not(.hover) a {color:#000000;} .page-id-5451 li#menu-item-2390.current-menu-ancestor:not(.hover) a:after {display:none;} /* Contact Customer Support nav issue fix*/ .page-id-9343 li#menu-item-2390.current-menu-ancestor:not(.hover) a {color:#000000;} .page-id-9343 li#menu-item-2390.current-menu-ancestor:not(.hover) a:after {display:none;} /* custom seach box*/ .search #Content .searchform {display:inline-block; float:left;} .search #Content .searchform h4{clear:both; padding:10px 0px; margin:0px;} .search #Content .searchform input[type=text] {float:left; margin:0px; min-width:350px; padding:7px 10px;} .search #Content .searchform select {-webkit-appearance:menulist; padding:7px 10px;} .search #Content .searchform input[type=submit] {background:#0065a4; margin:0px; margin-left:15px; padding:8px 20px;} @media only screen and (min-width: 320px) and (max-width: 650px) { .search #Content .searchform input[type=text] {min-width:240px;} } @media only screen and (min-width: 320px) and (max-width: 519px) { .search #Content .searchform input[type=submit] {margin:0px; margin-top:15px;} } .wpcf7-form .anr_captcha_field {position:absolute;} /*newsletter archive tables remove border*/ .post.category-newsletter-archive .post-wrapper-content table td {box-shadow:none; border:0px;} .be-ix-link-block {max-width:750px; text-align:center; margin:0px auto; padding-top:20px;} #Footer .widgets_wrapper .column {margin:0px 9px 0px;} @media only screen and (min-width: 768px) and (max-width: 959px) { #Footer .widgets_wrapper .column {margin:0px 5px 0px;} } /*Login page popup */ .page-id-5451.logged-in #pum-8728 {display:none !important;} #cookie-law-info-bar a {color:#fff; text-decoration:underline;} #cookie-law-info-bar a:hover {text-decoration:none;} #cookie-law-info-bar .cli-plugin-button {text-decoration:none;} @media only screen and (min-width: 320px) and (max-width: 767px) { #cookie-law-info-again{display:none !important;} } /*After Multi Language SETUP*/ #Action_bar .column {overflow:visible;} .top-widgets-container .widget_search input[type="text"] {margin-top:5px;} .widget.widget_nav_menu::after, .widget.widget_icl_lang_sel_widget::after, .widget_archive ul li:after, .widget_nav_menu ul li:after {display:none;} .wpml-ls-legacy-dropdown-click {margin-top:6px; } .wpml-ls-legacy-dropdown-click a, .wpml-ls-legacy-dropdown-click a:hover, .wpml-ls-legacy-dropdown-click a:focus, .wpml-ls-legacy-dropdown-click .wpml-ls-current-language:hover>a {color:#626262 !important; border:0px;text-decoration:none;} .wpml-ls-legacy-dropdown-click .wpml-ls-sub-menu {z-index:999;} .top-widgets-container h2.title {display:none;} @media only screen and (min-width: 320px) and (max-width: 767px) { .wpml-ls-legacy-dropdown-click {margin:6px auto 0px; } .top-widgets-container .widget_search {clear:both;} } @media only screen and (min-width: 768px) and (max-width: 959px) { .wpml-ls-legacy-dropdown-click {width:auto;} } #menu-top-navigation-ch .cart a {padding:0px 20px; } #menu-top-navigation-ch .cart a:before {font-family: "mfn-icons"; content:'\e82d'; float:left; padding-right:10px; font-size:26px; color:#fff; text-indent:0;} @media only screen and (min-width:320px) and (max-width:767px) { #menu-top-navigation-ch .cart.menu-item-2449 {display:none;} #menu-top-navigation-ch .cart a {padding:0px 10px;} } @media only screen and (min-width: 1240px) { .mm-vertical #Top_bar .menu > li#menu-item-13087 a span {background:#007dc5; color:#fff; border-radius:10px; line-height:40px; margin-top:8px; margin-left:20px;} .mm-vertical #Top_bar .menu > li#menu-item-13087 a:after {display:none;} #Top_bar.is-sticky .menu > li#menu-item-13087 > a, #Top_bar.is-sticky .menu > li#menu-item-13087 > a span {line-height:30px; margin-top:0px;} } .post-9911 .wpcf7 span.wpcf7-list-item{width: 260px;display: inline-block;} .post-9911 span.wpcf7-form-control-wrap{margin-bottom:20px;} .post-9911 .wpcf7-list-item-label{color:#000000;} .post-9911 .unique .one-third.column{width:30.333% !important;} .post-9911 .unique .required{color: #ff0000; font-size: 13px; padding: 0 5px 0 5px;} .post-9911 .wrap .one-second.column{width:32%;} .post-9911 .wpcf7 hr.small {color:#000000;background-color:#000000;height:1px; max-width: 440px;margin-bottom: 15px;margin-left:0px;margin-top:25px;} .post-9911 .wpcf7 hr.large{color:#000000;background-color:#000000;height:1px; max-width: 760px;margin-bottom: 15px;margin-left:0px;margin-top:25px;} .post-9911 .wpcf7 p strong{font-weight:normal; font-size:18px; color:#1F497D;} @media only screen and (min-width: 320px) and (max-width: 959px) { .post-9911 .wpcf7 span.wpcf7-list-item{width: 100%;} .post-9911 .unique .one-third.column{width:100% !important;} .post-9911 .wrap .one-second.column{width:100%;} .post-9911 span.wpcf7-form-control-wrap {margin-bottom:0px;} } /*remove meta from search-results*/ .search.search-results .post-item .post-meta {display:none;} .search.search-results .post-item .post-desc {padding-left:0px;} /*footer update*/ /*#Footer .widgets_wrapper {padding-bottom:10px;} #Footer .widgets_wrapper .column {margin-bottom:10px;} #Footer #custom_html-4 > h4 {text-align:center;} #Footer #custom_html-14 > h4 {text-align:center;} #Footer #custom_html-9 {max-width:160px; margin:0px auto; clear:both; padding-top:25px;} .footer-resources {max-width:80%; margin:0px auto; } .footer-resources li {float:left; line-height:28px;} .footer-resources li:nth-child(1), .footer-resources li:nth-child(6){width:12%; clear:both;} .footer-resources li:nth-child(2), .footer-resources li:nth-child(7){width:28%;} html[lang="zh-hans"] .footer-resources li:nth-child(1), html[lang="zh-hans"] .footer-resources li:nth-child(6){width:15%; clear:both;} html[lang="zh-hans"] .footer-resources li:nth-child(2), html[lang="zh-hans"] .footer-resources li:nth-child(7){width:25%;} .footer-resources li:nth-child(3), .footer-resources li:nth-child(8){width:17%;} .footer-resources li:nth-child(4), .footer-resources li:nth-child(9){width:18%;} .footer-resources li:nth-child(5), .footer-resources li:nth-child(10){width:25%;} @media only screen and (min-width:320px) and (max-width:1239px) { .footer-resources {max-width:60%; } .footer-resources li:nth-child(1), .footer-resources li:nth-child(6){width:50%; clear:none;} .footer-resources li:nth-child(2), .footer-resources li:nth-child(7){width:50%;} .footer-resources li:nth-child(3), .footer-resources li:nth-child(8){width:50%;} .footer-resources li:nth-child(4), .footer-resources li:nth-child(9){width:50%;} .footer-resources li:nth-child(5), .footer-resources li:nth-child(10){width:50%;} } @media only screen and (min-width:320px) and (max-width:767px) { .footer-resources {max-width:100%; } #Footer #custom_html-4 > h4 {text-align:left;} #Footer #custom_html-14 > h4 {text-align:left;} #Footer #custom_html-9 {max-width:100%;} } */ .tabs_vertical.ui-tabs .ui-tabs-nav li a.button, .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active a.button, .tabs_vertical.ui-tabs .ui-tabs-nav li a.button:hover, .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active a.button:hover { background: #007dc5; color: #fff; border-radius: 10px !important; text-align: center; margin-left: 20px; margin-top: 20px; display:inline-block; text-decoration: none; padding: 0px 20px !important; border:0px; text-transform: uppercase; line-height:30px; font-size: 15px; font-weight: 400;letter-spacing: 1px;} @media only screen and (min-width:320px) and (max-width:767px) { .tabs_vertical.ui-tabs .ui-tabs-nav li h3, .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active h3 {text-align:center;} .tabs_vertical.ui-tabs .ui-tabs-nav li a.button, .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active a.button, .tabs_vertical.ui-tabs .ui-tabs-nav li a.button:hover, .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active a.button:hover {margin:20px auto;} } /*Webinars latest posts zh-hans*/ .parent-pageid-11725 .Latest_news ul li {margin-top:15px; margin-bottom:15px;} .parent-pageid-11725 .Latest_news ul li.has-post-thumbnail .desc {margin-left: 70px; width: 95%;} .parent-pageid-11725 .Latest_news ul li .photo {width:70px; border-right:0px; text-align:center; display:table;} .parent-pageid-11725 .Latest_news ul li .photo a {display:table-cell; vertical-align:middle;} .parent-pageid-11725 .Latest_news ul li .photo img {max-width:50px !important; vertical-align:middle;} .parent-pageid-11725 .Latest_news ul li .desc {border-left:3px solid #000; padding-top:0px; padding-bottom:0px; display:table-cell; vertical-align:middle;} .parent-pageid-11725 .Latest_news ul li.category-webinars-zh-hans .desc h5 a{color:#007dc5;} .parent-pageid-11725 .Latest_news ul li .desc_footer .date {display:none;} .parent-pageid-11725 .Latest_news ul li .desc_footer .icon-comment-empty-fa {display:none} .parent-pageid-11725 .Latest_news ul li .desc_footer .post-comments {display:none;} .parent-pageid-11725 .Latest_news ul li .desc_footer .button-love {display:none;} .parent-pageid-11725 .Latest_news ul li .desc .post-excerpt {margin-top:0px;} .parent-pageid-11725 .Latest_news ul li .desc .post-excerpt p{margin-bottom:0px; line-height:20px;} /*Upcoming Live Webinars zh-hans*/ .page-id-11764 .Latest_news ul li {margin-top:15px; margin-bottom:15px;} .page-id-11764 .Latest_news ul li.has-post-thumbnail .desc {margin-left: 70px; width: 95%;} .page-id-11764 .Latest_news ul li .photo {width:70px; border-right:0px; text-align:center; display:table;} .page-id-11764 .Latest_news ul li .photo a {display:table-cell; vertical-align:middle;} .page-id-11764 .Latest_news ul li .photo img {max-width:50px !important; vertical-align:middle;} .page-id-11764 .Latest_news ul li .desc {border-left:3px solid #000; padding-top:0px; padding-bottom:0px; display:table-cell; vertical-align:middle;} .page-id-11764 .Latest_news ul li.category-webinars-zh-hans .desc h5 a{color:#007dc5;} .page-id-11764 .Latest_news ul li .desc_footer .date {display:none;} .page-id-11764 .Latest_news ul li .desc_footer .icon-comment-empty-fa {display:none} .page-id-11764 .Latest_news ul li .desc_footer .post-comments {display:none;} .page-id-11764 .Latest_news ul li .desc_footer .button-love {display:none;} .page-id-11764 .Latest_news ul li .desc .post-excerpt {margin-top:0px;} .page-id-11764 .Latest_news ul li .desc .post-excerpt p{margin-bottom:0px; line-height:20px;} /*Request Product Quote zh-hans*/ .page-id-12227 .wpcf7 span.wpcf7-list-item{width: 260px;display: inline-block;} .page-id-12227 span.wpcf7-form-control-wrap{margin-bottom:20px;} .page-id-12227 .wpcf7-list-item-label{color:#000000;} .page-id-12227 .unique .one-third.column{width:29% !important;} .page-id-12227 .unique .required{color: #ff0000; font-size: 13px; padding: 0 5px 0 5px;} .page-id-12227 .wrap .one-second.column{width:32%;} .page-id-12227 .wpcf7 hr.small {color:#000000;background-color:#000000;height:1px; max-width: 440px;margin-bottom: 15px;margin-left:0px;margin-top:25px;} .page-id-12227 .wpcf7 hr.large{color:#000000;background-color:#000000;height:1px; max-width: 760px;margin-bottom: 15px;margin-left:0px;margin-top:25px;} .page-id-12227 .wpcf7 p strong{font-weight:normal; font-size:18px; color:#1F497D;} @media only screen and (min-width: 320px) and (max-width: 959px) { .page-id-12227 .wpcf7 span.wpcf7-list-item{width: 100%;} .page-id-12227 .unique .one-third.column{width:100% !important;} .page-id-12227 .wrap .one-second.column{width:100%;} .page-id-12227 span.wpcf7-form-control-wrap {margin-bottom:0px;} } /*Request Product Info zh-hans*/ .page-id-12612 .wpcf7 span.wpcf7-list-item{width: 260px;display: inline-block;} .page-id-12612 span.wpcf7-form-control-wrap{margin-bottom:20px;} .page-id-12612 .wpcf7-list-item-label{color:#000000;} .page-id-12612 .unique .one-third.column{width:29% !important;} .page-id-12612 .unique .required{color: #ff0000; font-size: 13px; padding: 0 5px 0 5px;} .page-id-12612 .wrap .one-second.column{width:32%;} .page-id-12612 .wpcf7 hr.small {color:#000000;background-color:#000000;height:1px; max-width: 440px;margin-bottom: 15px;margin-left:0px;margin-top:25px;} .page-id-12612 .wpcf7 hr.large{color:#000000;background-color:#000000;height:1px; max-width: 760px;margin-bottom: 15px;margin-left:0px;margin-top:25px;} .page-id-12612 .wpcf7 p strong{font-weight:normal; font-size:18px; color:#1F497D;} @media only screen and (min-width: 320px) and (max-width: 959px) { .page-id-12612 .wpcf7 span.wpcf7-list-item{width: 100%;} .page-id-12612 .unique .one-third.column{width:100% !important;} .page-id-12612 .wrap .one-second.column{width:100%;} .page-id-12612 span.wpcf7-form-control-wrap {margin-bottom:0px;} } /*Team in zh-hans*/ .page-id-12002.if-overlay .image_frame:hover .image_wrapper img, .page-id-12002.if-overlay .image_frame.hover .image_wrapper img {transform: scale(1);} .page-id-12002 .team .desc_wrapper hr {display:none;} .page-id-12002 .ui-tabs .ui-tabs-panel .column.one-second, .page-id-12002 .ui-tabs .ui-tabs-panel .column.one-fourth, .page-id-12002 .ui-tabs .ui-tabs-panel .column.one-third, .page-id-12002 .ui-tabs .ui-tabs-panel .column.two-third {margin-left:10px; margin-right:10px;} .page-id-12002 .ui-tabs .ui-tabs-panel .column.one-fourth {width:23.4%;} /* product page in zh-hans*/ .page-id-12156 .ui-tabs-panel .team.team_vertical .image_frame {border:0px;} .page-id-12156 .ui-tabs-panel .team.team_vertical hr.hr_color {background:none;} .page-id-12156.if-overlay .ui-tabs-panel .team.team_vertical .image_frame:hover .image_wrapper img, .page-id-12156.if-overlay .ui-tabs-panel .team.team_vertical .image_frame.hover .image_wrapper img {-webkit-transform: scale(1); -moz-transform: scale(1); -o-transform: scale(1); transform: scale(1); } .page-id-12156 .ui-tabs-panel .one-third.column:nth-child(4n-3) {margin-left:10px; margin-right:17px; } .page-id-12156 .ui-tabs-panel .one-third.column:nth-child(4n-2) {margin-left:18px; margin-right:17px; } .page-id-12156 .ui-tabs-panel .one-third.column:nth-child(4n-1) {margin-left:18px; margin-right:10px; } .page-id-12156 .ui-tabs-panel .one-second.column:nth-child(odd) {margin-left:65px; margin-right:52px; } .page-id-12156 .ui-tabs-panel .one-second.column:nth-child(even) {margin-left:53px; margin-right:65px; } @media only screen and (min-width: 1301px) { .page-id-12156 .ui-tabs-panel .one-third.column {width:30.9%;} .page-id-12156 .ui-tabs-panel .one-second.column {width:40.2%;} } @media only screen and (min-width: 1240px) and (max-width: 1300px) { .page-id-12156 .ui-tabs-panel .one-third.column {width:30.7%;} .page-id-12156 .ui-tabs-panel .one-second.column {width:47.6%;} } @media only screen and (min-width: 960px) and (max-width: 1239px) { .page-id-12156 .ui-tabs-panel .one-third.column {width:29.9%;} .page-id-12156 .ui-tabs-panel .one-second.column {width:36.6%;} } @media only screen and (min-width: 768px) and (max-width: 959px) { .page-id-12156 .ui-tabs-panel .one-third.column {width:28.7%;} .page-id-12156 .ui-tabs-panel .one-second.column {width:38.9%;} } @media only screen and (min-width: 320px) and (max-width: 767px) { .page-id-12156 .ui-tabs-panel .one-third.column {margin-left:0px; margin-right:0px;} .page-id-12156 .ui-tabs-panel .one-second.column:nth-child(even), .page-id-12156 .ui-tabs-panel .one-second.column:nth-child(odd) {margin-left:0px; margin-right:0px;} } /*Recent Webinars nav issue fix for zh-hans*/ .page-id-11728 li#menu-item-13052.current-menu-ancestor:not(.hover) a {color:#000000;} .page-id-11728 li#menu-item-13052.current-menu-ancestor:not(.hover) a:after {display:none;} .large h3{font-size:22px; line-height:30px;} .small {margin-left:25px;} sup {display:inline-block; margin-top:-4px;} sub {display:inline-block; margin-bottom:-4px;} sup, sub {display:inline-table;} .ui-tabs-panel .one-second.column {width:50%;} .parent-pageid-2582 .ui-tabs-panel td {text-align:left !important;} .ls-borderlessdark3d .ls-shadow { display: none !important;} #menu-top-navigation-de .cart a {padding:0px 20px;} #menu-top-navigation-de .cart a:before {font-family: "mfn-icons"; content:'\e82d'; float:left; padding-right:15px; font-size:26px; color:#fff; text-indent:0;} @media only screen and (min-width:320px) and (max-width:767px) { #menu-top-navigation-de .cart.menu-item-14543{display:none;} #menu-top-navigation-de .cart a {padding:0px 10px;} } @media only screen and (min-width: 1240px) { .mm-vertical #Top_bar .menu > li#menu-item-15087 a span {background:#007dc5; color:#fff; border-radius:10px; line-height:40px; margin-top:8px; margin-left:20px;} .mm-vertical #Top_bar .menu > li#menu-item-15087 a:after {display:none;} #Top_bar.is-sticky .menu > li#menu-item-15087 > a, #Top_bar.is-sticky .menu > li#menu-item-15087 > a span {line-height:30px; margin-top:0px;} } @media only screen and (min-width: 1240px) { .mm-vertical #Top_bar li#menu-item-12984 a {color:#000 !important; padding-top:20px !important;} .mm-vertical #Top_bar li#menu-item-14978 a {color:#000 !important; padding-top:20px !important;} } #Footer #custom_html-15 > h4 {text-align:center;} /* product page German */ .page-id-14845 .ui-tabs-panel .team.team_vertical .image_frame {border:0px;} .page-id-14845 .ui-tabs-panel .team.team_vertical hr.hr_color {background:none;} .page-id-14845.if-overlay .ui-tabs-panel .team.team_vertical .image_frame:hover .image_wrapper img, .page-id-14295.if-overlay .ui-tabs-panel .team.team_vertical .image_frame.hover .image_wrapper img {-webkit-transform: scale(1); -moz-transform: scale(1); -o-transform: scale(1); transform: scale(1); } .page-id-14845 .ui-tabs-panel .one-third.column:nth-child(4n-3) {margin-left:10px; margin-right:17px; } .page-id-14845 .ui-tabs-panel .one-third.column:nth-child(4n-2) {margin-left:18px; margin-right:17px; } .page-id-14845 .ui-tabs-panel .one-third.column:nth-child(4n-1) {margin-left:18px; margin-right:10px; } .page-id-14845 .ui-tabs-panel .one-second.column:nth-child(odd) {margin-left:65px; margin-right:52px; } .page-id-14845 .ui-tabs-panel .one-second.column:nth-child(even) {margin-left:53px; margin-right:65px; } @media only screen and (min-width: 1301px) { .page-id-14845 .ui-tabs-panel .one-third.column {width:30.9%;} .page-id-14845 .ui-tabs-panel .one-second.column {width:40.2%;} } @media only screen and (min-width: 1240px) and (max-width: 1300px) { .page-id-14845 .ui-tabs-panel .one-third.column {width:30.7%;} .page-id-14845 .ui-tabs-panel .one-second.column {width:47.6%;} } @media only screen and (min-width: 960px) and (max-width: 1239px) { .page-id-14845 .ui-tabs-panel .one-third.column {width:29.9%;} .page-id-14845 .ui-tabs-panel .one-second.column {width:36.6%;} } @media only screen and (min-width: 768px) and (max-width: 959px) { .page-id-14845 .ui-tabs-panel .one-third.column {width:28.7%;} .page-id-14845 .ui-tabs-panel .one-second.column {width:38.9%;} } @media only screen and (min-width: 320px) and (max-width: 767px) { .page-id-14845 .ui-tabs-panel .one-third.column {margin-left:0px; margin-right:0px;} .page-id-14845 .ui-tabs-panel .one-second.column:nth-child(even), .page-id-14845 .ui-tabs-panel .one-second.column:nth-child(odd) {margin-left:0px; margin-right:0px;} } .parent-pageid-14845 .ui-tabs-panel td {text-align:left !important;} .button_align.align_left .button {text-align:left; padding:10px 0;} .button_align.align_left .as_tab {font-size: 18px; line-height: 20px; font-weight: 400; background:#fff; letter-spacing: 0px; color: #2991d6 !important; padding: 5px 10px 5px 20px;margin:0; } .button_align.align_left .button.as_tab:hover {text-decoration:underline !important; background-color:#fff!important;} .button_align.align_left .button.as_tab:after {display:none;} .button_align.align_left .button.as_tab.active {color: #000; border-left: 3px solid #2991d6; border-radius: 0px !important; padding: 5px 10px 5px 17px !important;} .button_align.align_left .button.as_tab .button_label {margin:0!important;} .button_align.align_left .button.as_tab_btn { background: #007dc5; color: #fff; border-radius: 10px !important; text-align: center; margin-left: 20px; margin-top: 20px; display: inline-block; text-decoration: none; padding: 0px 20px !important; border: 0px; text-transform: uppercase; line-height: 30px; font-size: 15px; font-weight: 400; letter-spacing: 1px; } /*Japan language*/ #Footer #custom_html-22 > h4 { text-align: center; } #menu-top-navigation-ja .cart a {padding:0px 20px;} #menu-top-navigation-ja .cart a:before {font-family: "mfn-icons"; content:'\e82d'; float:left; padding-right:15px; font-size:26px; color:#fff; text-indent:0;} @media only screen and (min-width:320px) and (max-width:767px) { #menu-top-navigation-ja .cart.menu-item-2449 {display:none;} #menu-top-navigation-ja .cart a {padding:0px 10px;} } .mm-vertical #Top_bar .menu > li#menu-item-18403 a span {background:#007dc5; color:#fff; border-radius:10px; line-height:40px; margin-top:8px; margin-left:20px;} .mm-vertical #Top_bar .menu > li#menu-item-18403 a:after {display:none;} #Top_bar.is-sticky .menu > li#menu-item-18403 > a, #Top_bar.is-sticky .menu > li#menu-item-18403 > a span {line-height:30px; margin-top:0px;} @media only screen and (min-width: 1240px) { #Top_bar #menu-german-main-menu > li > a span:not(.description) { padding: 0 3px; font-size:14px; } } body, ul.timeline_items, .icon_box a .desc, .icon_box a:hover .desc, .feature_list ul li a, .list_item a, .list_item a:hover, .widget_recent_entries ul li a, .flat_box a, .flat_box a:hover, .story_box .desc, .content_slider.carousel ul li a .title, .content_slider.flat.description ul li .desc, .content_slider.flat.description ul li a .desc, .post-nav.minimal a i { color: #333333 !important; } .column_column ul, .column_column ol, .the_content_wrapper:not(.is-elementor) ul, .the_content_wrapper:not(.is-elementor) ol { color: #333333 !important; } .hero { margin-top: 20px; } .bg-hero { background: radial-gradient(circle at 100% 0,#ebf1f2 0% 30%,#0e81a7 100%); } .hero-full { min-height: 450px; background-color: rgba(0, 0, 0, 0.5); } .column, .columns { margin: 0px 8px 40px; } .image-container { position: relative; display: inline-block; /* oder 'block' je nach Layout */ } .ribbon { position: absolute; top: 10px; /* Abstand von oben */ left: -20px; /* Verschiebung nach links, um das Ribbon schräg zu positionieren */ background-color: #FF5733; /* Farbe des Ribbons */ color: white; /* Textfarbe */ padding: 5px 15px; /* Innenabstand */ transform: rotate(-0deg); /* Dreht das Ribbon */ transform-origin: 0 0; /* Setzt den Drehpunkt */ font-size: 14px; /* Schriftgröße */ box-shadow: 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class="icon-menu-fine"></i></a> </div> <div class="secondary_menu_wrapper">  </div> <div class="banner_wrapper"> </div> <div class="search_wrapper">  <form role="search" method="get" id="searchform2" class="searchform" action="https://www.wyatt.com/" > <div><input type="text" placeholder="Search..." value="" name="s" id="s" /> <a href="javascript:document.getElementById('searchform2').submit();" class="icon-search-fine"></a> </div> </form><div class="mobilecart"><a href="https://store.wyatt.com/"></a></div> </div> </div> </div> </div> </div> </header> </div>  <div id="Content" role="main"> <div class="content_wrapper clearfix"> <main class="sections_group"> <div class="entry-content" itemprop="mainContentOfPage"> <div class="mfn-builder-content mfn-default-content-buider"><section class="section mcb-section mfn-default-section mcb-section-f8ed2b430 header-section default-width" style="" ><div class="mcb-background-overlay"></div><div class="section_wrapper mfn-wrapper-for-wraps mcb-section-inner mcb-section-inner-f8ed2b430"><div class="wrap mcb-wrap mcb-wrap-17d806d93 one tablet-one laptop-one mobile-one clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-17d806d93 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="wrap mcb-wrap mcb-wrap-7231b465c one-second tablet-one-second laptop-one-second mobile-one mfn-nested-wrap clearfix" data-desktop-col="one-second" data-laptop-col="laptop-one-second" data-tablet-col="tablet-one-second" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-7231b465c mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-6fa1340cf one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-6fa1340cf mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h1 style="color: white;">Biotherapeutics</h1> <p style="font-size: 18px;">Multi-Angle Light Scattering (MALS) and high-throughput Dynamic Light Scattering (DLS) instruments provide powerful tools for characterizing biomolecule candidates across many excipients and buffer conditions.</p></div></div></div></div></div></div></div></div></section><section class="section mcb-section mfn-default-section mcb-section-iajsfw7hn" style="" ><div class="mcb-background-overlay"></div><div class="section_wrapper mfn-wrapper-for-wraps mcb-section-inner mcb-section-inner-iajsfw7hn"><div class="wrap mcb-wrap mcb-wrap-nnrpktnw0 one tablet-one laptop-one mobile-one valign-top clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="padding:;background-color:" ><div class="mcb-wrap-inner mcb-wrap-inner-nnrpktnw0 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-fqi6xj3rw one laptop-one tablet-one mobile-one column_column column-margin-20px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-fqi6xj3rw mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""> </div></div></div></div></div></div></section><section class="section mcb-section mfn-default-section mcb-section-556dc09d1 default-width" style="" ><div class="mcb-background-overlay"></div><div class="section_wrapper mfn-wrapper-for-wraps mcb-section-inner mcb-section-inner-556dc09d1"><div class="wrap mcb-wrap mcb-wrap-515cd6c0c one-fourth tablet-one-fourth laptop-one-fourth mobile-one sticky-desktop clearfix" data-desktop-col="one-fourth" data-laptop-col="laptop-one-fourth" data-tablet-col="tablet-one-fourth" data-mobile-col="mobile-one" style="--sticky-offset-desktop:110px" ><div class="mcb-wrap-inner mcb-wrap-inner-515cd6c0c mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="wrap mcb-wrap mcb-wrap-9257d5fc5 one tablet-one laptop-one mobile-one mfn-item-custom-width mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-9257d5fc5 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-b6f0ba916 one laptop-one tablet-one mobile-one column_table_of_contents" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-b6f0ba916 mcb-item-table_of_contents-inner"><div class="table_of_content clearfix " data-tags="H2"><div class="title"><h4 class="title-inner">Table of contents</h4></div><div class="table_of_content_wrapper"><ol class="mfn_toc_numbers"><li data-depth="1" ><i></i><a class="scroll" href="#introduction">Introduction</a></li><li><i></i><a class="scroll" href="#target-candidate-proteins">Target & Candidate Proteins</a></li><li><i></i><a class="scroll" href="#candidate-selection-optimization">Candidate Selection & Optimization</a></li><li><i></i><a class="scroll" href="#process-development">Process Development</a></li><li><i></i><a class="scroll" href="#formulation">Formulation</a></li><li><i></i><a class="scroll" href="#high-concentration-formulation">High-Concentration Formulation</a></li><li><i></i><a class="scroll" href="#biophysical-characterization">Biophysical Characterization</a></li><li><i></i><a class="scroll" href="#vaccines">Vaccines</a></li><li><i></i><a class="scroll" href="#process-analytical-technology">Process Analytical Technology</a></li><li><i></i><a class="scroll" href="#resources">Resources</a></li></ol></div></div> </div></div><div class="column mcb-column mcb-item-t3elrrm0c one laptop-one tablet-one mobile-one column_plain_text" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-t3elrrm0c mcb-item-plain_text-inner"><div class="desc"><a href="https://www.wyatt.com/products/request-product-info.html" class="sidebar-btn" target="_blank" rel="noopener noreferrer"> Request Product Information </a></div></div></div></div></div></div></div><div class="wrap mcb-wrap mcb-wrap-d3ef82352 three-fourth tablet-three-fourth laptop-three-fourth mobile-one clearfix" data-desktop-col="three-fourth" data-laptop-col="laptop-three-fourth" data-tablet-col="tablet-three-fourth" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-d3ef82352 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div id="introduction" class="wrap mcb-wrap mcb-wrap-c04cbf8f2 one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-c04cbf8f2 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-8dd5ddba3 one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-8dd5ddba3 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">Introduction</h2> <p><div class="image_frame image_item no_link scale-with-grid alignright no_border" style="margin-bottom:10px;"><div class="image_wrapper "><img class="scale-with-grid" src="/wp-content/uploads/2019/05/igg.png" alt="IgG" title="" width="250" height="" style=""/></div></div> </p> <p>Development of efficacious and robust biologics is a complex process. Light scattering technologies assist at each stage with uniquely versatile technologies for biophysical screening and characterization, from target and candidate discovery to selection, optimization, purification, formulation and manufacturing scale-up.</p> <p>Some key applications of light scattering in biotherapeutic development are described below.</p></div></div></div></div></div><div id="target-candidate-proteins" class="wrap mcb-wrap mcb-wrap-76a30f6a1 one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-76a30f6a1 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-5e6961ff5 one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-5e6961ff5 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">Target & Candidate Proteins</h2> <p>Once target proteins and candidate biomolecules for a given indication have been identified, they must be produced at a small scale in sufficient quantities and appropriate quality for further R&D.</p> <h3>Soluble aggregates</h3> <p>Size exclusion chromatography with multi-angle light scattering (<a href="/solutions/techniques/sec-mals-molar-mass-size-multi-angle-light-scattering.html">SEC-MALS</a>) accurately characterizes proteins and other biomolecules for soluble aggregates, regardless of non-ideal column interactions, to quickly identify optimal purification conditions.</p> <h3>Stability</h3> <p>High-throughput dynamic light scattering (<a href="/solutions/techniques/dynamic-light-scattering-nanoparticle-size.html">DLS</a>) using the <a href="/products/instruments/dynapro-dynamic-light-scattering-plate-reader.html">DynaPro<sup>™</sup> Plate Reader</a> requires minimal sample quantities and time to assess candidates and pre-formulation conditions for stability and propensity for aggregation.</p> <h3>Interactions</h3> <p>Composition-gradient, multi-angle light scattering (<a href="/solutions/techniques/cg-mals-label-free-biomolecular-interactions.html">CG-MALS</a>) combining a <a href="/products/instruments/calypso-ii-label-free-biomolecular-interactions.html">Calypso<sup>™</sup></a> composition-gradient system and <a href="/products/instruments/dawn-multi-angle-light-scattering-detector.html">DAWN<sup>™</sup></a> MALS detector determines affinity and absolute stoichiometry of drug-target binding, without labeling or immobilization. It is particularly well suited for studying multivalent interactions or drug-target binding in the presence of self-association, including virus-like particles (VLPs), monomeric antibodies, oligonucleotides or peptides.</p></div></div></div></div></div><div id="candidate-selection-optimization" class="wrap mcb-wrap mcb-wrap-e36b49b13 one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-e36b49b13 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-49cf37c57 one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-49cf37c57 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">Candidate Selection & Optimization</h2> <p>Post-translational modifications such as glycosylation or PEGylation are often applied to proteins or peptides in order to improve stability and increase physiological retention time. Some biologics, such as insulin, are required to form well-defined oligomeric states for the same reason. Modification of IgG with conjugated, highly toxic drugs can convert an antibody to a potent anti-cancer substance.</p> <h3>Drug-Antibody Ratio</h3> <p>Triple-detection <a href="/solutions/techniques/sec-mals-molar-mass-size-multi-angle-light-scattering.html">SEC-MALS</a> utilizing combined UV, MALS and RI instruments readily determines the degree of glycosylation or PEGylation, and in many instances may be used to calculate the drug-antibody ratio (DAR) of antibody drug conjugates (ADCs).</p> <h3>Oligomerization</h3> <p><a href="/solutions/techniques/cg-mals-label-free-biomolecular-interactions.html">CG-MALS</a> analyzes reversible oligomerization by measuring the dependence of weight-average molar mass on concentration. The oligomeric order may be determined unambiguously, along with the affinity.</p> <p>Antibody engineering and other modifications by means of mutations to the genetic sequence may be carried out in order to improve stability or efficacy. SEC-MALS helps determine the impact of these changes on aggregation, while CG-MALS assesses how they have affected target binding properties.</p> <h3>Biocolloids</h3> <p>For larger entities such as virus-like particles (VLPs) and polymer, liposome or hydrogel-based drug carriers, separation by field-flow fractionation (<a href="/solutions/techniques/fff-mals-characterization-of-nanoparticles-colloids-macromolecules.html">FFF</a>) is usually preferable to size exclusion chromatography. The <a href="/products/instruments/eclipse-field-flow-fractionation-system.html">Eclipse<sup>™</sup></a> FFF system offer a variety of options for optimal separation, upstream of a MALS detector.</p></div></div></div></div></div><div id="process-development" class="wrap mcb-wrap mcb-wrap-83110145b one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-83110145b mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-ad2f49531 one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-ad2f49531 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">Process Development</h2> <p>Light scattering measurements help process development in several ways:</p> <h3>Purification end point</h3> <p>Since multi-angle light scattering determines molar masses independently of retention time, <a href="/solutions/techniques/real-time-mals.html">RT-MALS</a> is ideal for real-time characterization of purification products and determination of end points. For more detailed product characterization during process development, <a href="/solutions/techniques/sec-mals-molar-mass-size-multi-angle-light-scattering.html">SEC-MALS</a> may be implemented at-line with UHPLC for rapid separation and analysis.</p> <h3>Quaternary structure</h3> <p>Complex products such as virus-like particles or peptide micelles must be produced with specific masses, shapes and sizes, as well as minimum quantities of residual unassembled material. SEC-MALS or <a href="/solutions/techniques/fff-mals-characterization-of-nanoparticles-colloids-macromolecules.html">FFF-MALS</a> with <a href="/products/instruments/dynapro-nanostar-dynamic-light-scattering-detector.html">on-line DLS</a> validates such processes to quantify unassembled sub-units and ensure that the final product conforms to the required structure.</p></div></div></div></div></div><div id="formulation" class="wrap mcb-wrap mcb-wrap-efbe83395 one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-efbe83395 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-276341f20 one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-276341f20 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">Formulation</h2> <p>In the formulation process, many combinations of buffer conditions and excipients must be tested for stability and propensity for aggregation. Final selection of the most promising conditions for long-term testing does not necessarily require rigorous thermodynamic characterization, but does benefit from an understanding of multiple properties which reflect various facets of stability. <a href="/products/instruments/dynapro-dynamic-light-scattering-plate-reader.html">High-throughput DLS</a> is the ideal technique for this, as it can address multiple stability-indicating parameters simultaneously testing thousands of conditions per day:</p> <h3>Stability screening</h3> <ul> <li><i>Aggregation state</i> - formation of aggregates, size distribution and rate of formation. This is the basic DLS analysis.</li> <li><i>Thermal stability</i> - how temperature induces denaturing and non-native aggregation. Determined through temperature ramps, monitoring changes in molecular size.</li> <li><i>Chemical stability</i> - how buffer composition (pH, ionic strength, denaturing solvents such as guanidine) induces denaturing and non-native aggregation. Determined through composition steps, monitoring changes in molecular size.</li> <li><i>Colloidal stability</i> - how surface moieties such as charged residues or hydrophobic patches lead to aggregation, unrelated to changes in tertiary structure. Determined through the concentration dependence of translational diffusion, <i>k</i><sub>D</sub> or <i>D</i><sub>1</sub>.</li> </ul> <p>With the <a href="/products/instruments/dynapro-dynamic-light-scattering-plate-reader.html">DynaPro Plate Reader,</a> these measurements takes place <i>in situ</i> in standard 96, 384 or 1536 microwell plates, consuming minimal sample quantities. The same samples may be further tested <i>in the same or other plate-based instruments</i> [e.g., to analyze the temperature dependence of colloidal stability (in the DynaPro) or intrinsic fluorescence (in a spectroscopic plate reader)], making the DynaPro Plate Reader an invaluable tool for formulation screening. A software package enables integration of the instrument with robotic sample preparation and plate placement.</p> <h3>Molecular charge</h3> <p>Another helpful light scattering tool for formulation development is <a href="/solutions/techniques/mp-pals.html">Electrophoretic Light Scattering (ELS)</a>. The <a href="/products/instruments/mobius.html">Mobius<sup>™</sup></a> integrates with an autosampler and the <a href="https://store.wyatt.com/shop/mobius/atlas-pressurized-system/">Atlas<sup>™</sup></a> for automated measurement of molecular charge, an important parameter for stability. The measurement takes place in native buffers, even under moderate to high salt conditions. Like the DynaPro Plate Reader, the Mobius offers automated measurement of multiple parameters such as thermal and colloidal stability.</p> <h3>Turbidity/opalescence</h3> <p>Opalescence indicates aggregation and particle formation, reversible self-association (RSA), and liquid-liquid phase separation that leads to undesirable product properties. The <a href="/products/instruments/dynapro-nanostar-dynamic-light-scattering-detector.html">DynaPro<sup>™</sup> NanoStar<sup>™</sup></a> with microliter volumes provides quick <a href="/solutions/measuring-turbidity-opalescence.html">turbidity/opalescence</a> measurements of formulations.</p></div></div></div></div></div><div id="high-concentration-formulation" class="wrap mcb-wrap mcb-wrap-thno9a65 one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-thno9a65 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-k358fyp7p one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-k358fyp7p mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">High-Concentration Formulation</h2> <p>Additional characterization challenges in the course of high-concentration formulation of monoclonal antibodies and other biotherapeutics include understanding the interplay of weak interactions, and viscosity.</p> <h3>Protein-Protein interactions</h3> <p>Weak protein-protein interactions may not be important at low concentrations, and so are not necessarily reflected in dilute-condition parameters such as <i>k</i><sub>D</sub>, but come to dominate at high concentration. <a href="/solutions/techniques/cg-mals-label-free-biomolecular-interactions.html">CG-MALS</a> uniquely addresses these complex interactions through a theoretical framework known as the Minton-Chatelier formalism. This technique distinguishes attractive interactions causing aggregation, opalescence and viscosity, from repulsive interactions which may impact measurements but have little effect on stability.</p> <h3>Viscosity screening</h3> <p>Viscosity is both indicative of colloidal stability, and an important parameter on its own since high viscosity impacts manufacturability and deliverability of the final product. <a href="/solutions/techniques/dynamic-light-scattering-nanoparticle-size.html">DLS</a> readily determines viscosity of concentrated protein solutions using tracer beads. The <a href="/products/instruments/dynapro-dynamic-light-scattering-plate-reader.html">DynaPro Plate Reader</a> can evaluate the viscosity of samples as small as 10 µL in a few seconds, measuring thousands of conditions per day in order to screen for ideal viscosity-reducing excipients.</p> <h3>Turbidity or opalescence measurements</h3> <p>Turbidity becomes important in high-concentration formulations due to interactions between different species in solution resulting in opalescence and poor product quality. Turbidity of a solution is interpolated from a turbidity calibration plot. A quartz cuvette is calibrated against a series of turbidity standards, and the turbidity of a solution subsequently measured in that cuvette is calculated and displayed in the data table in nephelometric units (NTU). Visit our <a href="/solutions/measuring-turbidity-opalescence.html">turbidity page</a> to learn more.</p></div></div></div></div></div><div id="biophysical-characterization" class="wrap mcb-wrap mcb-wrap-c6vuboeba one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-c6vuboeba mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-jw1nhv74 one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-jw1nhv74 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">Biophysical Characterization</h2> <p>Light scattering is an essential part of any biophysical characterization lab for biotherapeutics, and is recognized by the FDA as a key technology for regulatory filings. Key applications include:</p> <h3>Aggregation</h3> <p>Applying orthogonal techniques based on light scattering and other instruments provided by Wyatt, analytical support labs can support regulatory filings with thoroughly validated, extended analysis of soluble and insoluble sub-micron aggregates. These techniques are:</p> <ul> <li><a href="/solutions/techniques/sec-mals-molar-mass-size-multi-angle-light-scattering.html">SEC-MALS</a> for robust characterization of the mass and size distributions of soluble, irreversible aggregates</li> <li><a href="/solutions/techniques/fff-mals-characterization-of-nanoparticles-colloids-macromolecules.html">FFF-MALS</a> for robust characterization the mass and size distributions of soluble and insoluble, irreversible aggregates</li> <li>Batch <a href="/solutions/techniques/dynamic-light-scattering-nanoparticle-size.html">DLS</a> for rapid testing of size distributions for soluble and insoluble, reversible and irreversible aggregates</li> <li><a href="/solutions/techniques/cg-mals-label-free-biomolecular-interactions.html">CG-MALS</a> for characterization of reversible aggregates or oligomers, as well as validation of SEC-MALS for loss of aggregates on the column.</li> </ul> <h3>Conjugation</h3> <p>Triple detection by UV-MALS-dRI determines the composition as well as molar mass distributions of:</p> <ul> <li>Protein-polysaccharide conjugated vaccines</li> <li>PEGylated proteins</li> <li>Antibody-drug conjugates</li> <li>glycoproteins</li> <li>VLPs with DNA/RNA payloads</li> </ul> <p>With the addition of a <a href="https://store.wyatt.com/shop/udawn/udawn3/wiq/">WyattQELS<sup>™</sup> DLS module</a>, the size distributions may be determined as well.</p> <ul> <li><i>Chemical disposition:</i> <a href="/solutions/techniques/mp-pals.html">ELS</a> determines charge state and so is an important indicator of surface chemistry.</li> <li><i>Functionality:</i> <a href="/solutions/techniques/cg-mals-label-free-biomolecular-interactions.html">CG-MALS</a> is a powerful technique for in-depth characterization of biomolecular interactions such as drug-target binding, without labeling or immobilization. Since it measures molar mass directly, it is particularly versatile for a range of valencies and self- as well as hetero-association.</li> </ul></div></div></div></div></div><div id="vaccines" class="wrap mcb-wrap mcb-wrap-xu0j84ne one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-xu0j84ne mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-yeas1b0pa one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-yeas1b0pa mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">Vaccines</h2> <p>The universe of vaccines is highly diverse, covering traditional vaccines based on live-attenuated or inactivated viruses and through the most advanced modalities utilizing gene therapy. Wyatt’s suite of solutions is essential in all stages of vaccine development, from basic virology through product characterization, production and quality control. Visit <a href="/solutions-vaccine-characterization.html">Solutions for vaccine characterization and development</a> to learn more.</p> <p><img src="/wp-content/uploads/2020/03/Production-Image-Update.jpg" align="middle" /></p></div></div></div></div></div><div id="process-analytical-technology" class="wrap mcb-wrap mcb-wrap-hx0vap6yi one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-hx0vap6yi mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-43pws9qm4 one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-43pws9qm4 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">Process Analytical Technology</h2> <p>In current biotherapeutic manufacturing strategies, “the process is the product” means that strict control of process parameters such as pH, temperature, and feedstock consumption is required to guarantee product quality. Only at the end of the process can QC procedures check the critical quality attributes (CQAs) that define product quality. Hence, most PAT instruments monitor process conditions rather than product attributes.</p> <p><img style="padding-left: 10px;" title="OBSERVER" src="/wp-content/uploads/2019/11/Observer-Software.jpg" alt="OBSERVER" width="400px" align="right" /></p> <p>Real-time multi-angle light scattering (<a href="/solutions/techniques/real-time-mals.html">RT-MALS</a>) is a novel PAT application of light scattering, that directly determines the molecular weight of mAbs and other therapeutic biomolecules. It is particularly sensitive to the appearance of aggregates and contaminant particles. Using the <a href="/products/instruments/ultradawn.html">ultraDAWN™</a> RT-MALS instrument, in-line or on-line with purification and other process steps, production staff can speed up and optimize process development with immediate feedback on the impact of process variations and deviations. UltraDAWN measures another attribute, the average radius, for virus-like particles and other biomolecular complexes with diameters above 25-30 nm.</p> <p>After developing the process, the ultraDAWN may be left on-line. Its accompanying software, <a>OBSERVER<sup>™</sup></a>, integrates with an OPC-UA environment for automated and/or GMP operation. OBSERVER can be programmed to trigger the system to react to deviations from the allowed molar mass range due to aggregation, or to shut down a reaction once the endpoint has been reached.</p></div></div></div></div></div><div id="resources" class="wrap mcb-wrap mcb-wrap-993e3d151 one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-993e3d151 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-ea49a0029 one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-ea49a0029 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">Resources</h2></div></div></div></div></div><div id="application-notes" class="wrap mcb-wrap mcb-wrap-2ee7f5425 one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-2ee7f5425 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-612144a3a one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-612144a3a mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h3>Application notes</h3> <div style="display: flex; align-items: center; gap: 8px; margin-bottom: 10px;"> <i class="fas fa-file-pdf" style="color: #8a8a8d; font-size: 22px; margin-right: 8px;"></i> <a href="https://wyattfiles.s3.us-west-2.amazonaws.com/literature/app-notes/sec-mals-proteins/insulin-oligomeric-state.pdf" target="_blank" rel="noopener">Identification of Insulin Oligomeric States</a> </div> <div style="display: flex; align-items: center; gap: 8px; margin-bottom: 10px;"> <i class="fas fa-file-pdf" style="color: #8a8a8d; font-size: 22px; margin-right: 8px;"></i> <a href="https://wyattfiles.s3.us-west-2.amazonaws.com/literature/app-notes/sec-mals-biopolymers/lcgc3-61-05e.pdf" target="_blank" rel="noopener">Hyaluronic Acid Characterization by Differential Viscometry and MALS</a> </div> <div style="display: flex; align-items: center; gap: 8px; margin-bottom: 10px;"> <i class="fas fa-file-pdf" style="color: #8a8a8d; font-size: 22px; margin-right: 8px;"></i> <a href="https://wyattfiles.s3.us-west-2.amazonaws.com/literature/app-notes/sec-mals-proteins/antibody-drug-conjugate-analysis.pdf" target="_blank" rel="noopener">Antibody Drug Conjugate (ADC) Analysis</a> </div> <div style="display: flex; align-items: center; gap: 8px; margin-bottom: 10px;"> <i class="fas fa-file-pdf" style="color: #8a8a8d; font-size: 22px; margin-right: 8px;"></i> <a href="https://wyattfiles.s3.us-west-2.amazonaws.com/literature/app-notes/dls-plate/diffusion-interaction-parameter.pdf" target="_blank" rel="noopener">The Diffusion Interaction Parameter <i>k</i><sub>D</sub> as an Indicator of Colloidal and Thermal Stability</a> </div> <div style="display: flex; align-items: center; gap: 8px; margin-bottom: 10px;"> <i class="fas fa-file-pdf" style="color: #8a8a8d; font-size: 22px; margin-right: 8px;"></i> <a href="https://wyattfiles.s3.us-west-2.amazonaws.com/literature/app-notes/cg-mals/self-associating-antibody.pdf" target="_blank" rel="noopener">Self-Associating Antibody Solutions at High Concentrations</a> </div> <div style="display: flex; align-items: center; gap: 8px; margin-bottom: 10px;"> <i class="fa-solid fa-arrow-up-right-from-square" style="color: #8a8a8d; font-size: 16px; margin-right: 8px;"></i> <a href="/appnotes.html" target="_blank" rel="noopener">MORE APPLICATIONS</a> </div> </div></div></div></div></div><div id="selected-references" class="wrap mcb-wrap mcb-wrap-5ed03049e one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-5ed03049e mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-4bd0aa928 one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-4bd0aa928 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h3>Selected References</h3> <p>Esfandiary, R.; Hayes, D. B.; Parupudi, A.; Casas-Finet, J.; Bai, S.; Samra, H. S.; Shah, A. U.; Sathish, H. A. <a href="https://scholar.google.com/scholar?q=10.1002%2Fjps.23654&btnG=&hl=en&as_sdt=0%2C5" target="_blank">A systematic multitechnique approach for detection and characterization of reversible self-association during formulation development of therapeutic antibodies</a>. <i>J. Pharm. Sci. </i> <b>2013,</b> <i>102</i>, 3089-3099.</p> <p>Lehermayr, C.; Mahler, H.-C.; Mäder, K.; Fischer, S. <a href="https://scholar.google.com/scholar?q=10.1002%2Fjps.22506&btnG=&hl=en&as_sdt=0%2C5" target="_blank">Assessment of net charge and protein-protein interactions of different monoclonal antibodies</a>. <i>J. Pharm. Sci. </i> <b>2011,</b> <i>100</i>, 2551-2562.</p> <p>Menzen, T.; Friess, W. <a href="https://scholar.google.com/scholar?q=10.1002%2Fjps.23827&btnG=&hl=en&as_sdt=0%2C5" target="_blank">Temperature-ramped studies on the aggregation, unfolding, and interaction of a therapeutic monoclonal antibody</a>. <i>J. Pharm. Sci. </i> <b>2014,</b> <i>103</i>, 445-455.</p> <p>Mohr, J.; Chuan, Y. P.; Wu, Y.; Lua, L. H. L.; Middelberg, A. P. J. <a href="https://scholar.google.com/scholar?q=10.1016%2Fj.ymeth.2013.04.019&btnG=&hl=en&as_sdt=0%2C5" target="_blank">Virus-like particle formulation optimization by miniaturized high-throughput screening</a>. <i>Methods </i> <b>2013,</b> <i>60</i>, 248-256.</p> <p>Rathore, A.; Krull, I. S.; Kreimer, S. <a href="http://www.chromatographyonline.com/use-light-scattering-detection-sec-and-hplc-protein-and-antibody-studies-part-i-background-theory-an" target="_blank">The Use of Light-Scattering Detection with SEC and HPLC for Protein and Antibody Studies, Part I: Background, Theory, and Potential Uses</a>. <i>LCGC North America </i> <b>2012,</b> <i>30(9)</i>.</p> <p>Rathore, A.; Krull, I. S.; Kreimer, S., Champagne, J. <a href="http://www.chromatographyonline.com/use-light-scattering-detection-sec-and-hplc-protein-and-antibody-studies-part-ii-examples-and-compar" target="_blank">The Use of Light-Scattering Detection with SEC and HPLC for Protein and Antibody Studies, Part II: Examples and Comparison to Mass Spectrometry</a>. <i>LCGC North America </i> <b>2012,</b> <i>30(12)</i>.</p> <p>Saito, S.; Hasegawa, J.; Kobayashi, N.; Tomitsuka, T.; Uchiyama, S.; Fukui, K. <a href="https://scholar.google.com/scholar?q=10.1007%2Fs11095-012-0965-4&btnG=&hl=en&as_sdt=0%2C5" target="_blank">Effects of ionic strength and sugars on the aggregation propensity of monoclonal antibodies: influence of colloidal and conformational stabilities</a>. <i>Pharm. Res. </i> <b>2013,</b> <i>30</i>, 1263-1280.</p> <p><a href="/library/bibliography.html" target="_blank">BIBLIOGRAPHIC SEARCH</a></p></div></div></div></div></div></div></div></div></section></div><section class="section mcb-section the_content no_content"></section> <section class="section section-page-footer"> <div class="section_wrapper clearfix"> <div class="column one page-pager"> <div class="mcb-column-inner"> </div> </div> </div> </section> </div> </main> </div> </div>  <section class="section before-footer mcb-section mfn-default-section mcb-section-arexmxc3 default-width" style="padding-top:70px;"><div class="mcb-background-overlay"></div><div class="section_wrapper mfn-wrapper-for-wraps mcb-section-inner mcb-section-inner-arexmxc3"><div class="wrap mcb-wrap mcb-wrap-jana9ffxy container one-third tablet-one-third laptop-one-third mobile-one clearfix" data-desktop-col="one-third" data-laptop-col="laptop-one-third" data-tablet-col="tablet-one-third" data-mobile-col="mobile-one" 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