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hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Flow Cytometry Kits & Reagents</a><a href="/browse?categories=Recombinant%20Proteins" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Recombinant Proteins</a><a href="/browse?categories=siRNA" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>siRNA</a><a href="/browse?categories=Cytokines%20%26%20Growth%20Factors" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Cytokines & Growth Factors</a><a href="/browse?categories=Activators%20%26%20Inhibitors" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Activators & Inhibitors</a><a href="/browse?categories=Buffers%20%26%20Dyes" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Buffers & Dyes</a><a href="/browse?formulation=BSA%20and%20Azide%20Free" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>BSA and Azide Free</a></div></div></div></div></div></li><li class="tw-group tw-px-[0.05em] lg:tw-relative nav-item-1" data-v-006bc605><a href="/applications" data-test-id="navigation-main_applications" class="navigation-main-link tw-hidden tw-p-4 lg:tw-block lg:tw-border-b-2 lg:tw-border-transparent lg:tw-py-2 lg:tw-px-0 lg:tw-uppercase lg:group-hover:tw-border-midnight-blue-500" data-v-006bc605><span class="tw-border-dusty-gray-300 lg:tw-border-r lg:tw-p-0 lg:tw-px-2 lg:group-last:tw-border-r-0" data-v-006bc605> Applications </span></a> <div class="tw-flex tw-cursor-pointer tw-items-center tw-justify-between tw-border-b tw-border-dusty-gray-300 tw-px-4 tw-py-2 lg:tw-hidden" data-v-006bc605><span data-v-006bc605> Applications </span> <i aria-hidden="true" class="cstf cstf-angle-right tw-text-2xl" data-v-006bc605></i></div> <div class="lg:tw-hidden" style="display:none" data-v-006bc605><button class="tw-block tw-h-8 tw-w-full tw-text-left" data-v-006bc605><i aria-hidden="true" class="cstf cstf-angle-left tw-px-4 tw-text-2xl" data-v-006bc605></i></button> <a href="/applications" class="tw-block tw-border-b tw-border-dusty-gray-300 tw-px-4 tw-py-2 tw-text-xl tw-font-bold tw-text-midnight-blue-500" data-v-006bc605> Applications </a></div> <div data-test-id="navigation-submenu_applications" class="menu-dropdown tw-bg-white lg:tw-absolute lg:tw-z-50 lg:tw-border-t-2 lg:tw-border-midnight-blue-500 lg:tw-shadow-lg" style="display:none" data-v-006bc605><div class="tw-flex tw-flex-col lg:tw-flex-row" data-v-006bc605> <div data-test-id="navigation-submenuSection_resource-centers" class="tw-flex tw-flex-col lg:tw-border-r lg:tw-py-2" data-v-006bc605><div class="tw-bg-dusty-gray-500 tw-px-2.5 tw-py-1.5 tw-text-xs tw-uppercase tw-text-white lg:tw-mx-2.5 lg:tw-mb-2.5" data-v-006bc605> Resource Centers </div>  <div class="menu-section tw-flex tw-flex-col lg:tw-flex-row resource-centers" data-v-006bc605><div class="tw-flex tw-flex-col tw-flex-wrap" data-v-006bc605><a href="/applications/chip-and-chip-seq" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>ChIP & ChIP-seq</a><a href="/applications/cut-and-run" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>CUT&RUN</a><a href="/applications/cut-tag" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>CUT&Tag</a><a href="/applications/elisa" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>ELISA</a><a href="/applications/flow-cytometry" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Flow Cytometry</a><a href="/applications/immunofluorescence" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Immunofluorescence</a><a href="/applications/immunohistochemistry" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Immunohistochemistry</a><a href="/applications/immunoprecipitation" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Immunoprecipitation</a><a href="/applications/intraseq-single-cell" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>InTraSeq™ Single Cell Analysis</a><a href="/applications/proteomics" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>LC/MS Proteomics</a><a href="/applications/multiplexing-and-spatial-biology" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Multiplexing and Spatial Biology</a><a href="/applications/signalstar-multiplex-ihc" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>SignalStar™ Multiplex IHC</a><a href="/applications/western-blot-immunoblot" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Western Blot (Immunoblot)</a></div></div></div></div></div></li><li class="tw-group tw-px-[0.05em] lg:tw-relative nav-item-2" data-v-006bc605><a href="/research" data-test-id="navigation-main_research" class="navigation-main-link tw-hidden tw-p-4 lg:tw-block lg:tw-border-b-2 lg:tw-border-transparent lg:tw-py-2 lg:tw-px-0 lg:tw-uppercase lg:group-hover:tw-border-midnight-blue-500" data-v-006bc605><span class="tw-border-dusty-gray-300 lg:tw-border-r lg:tw-p-0 lg:tw-px-2 lg:group-last:tw-border-r-0" data-v-006bc605> Research </span></a> <div class="tw-flex tw-cursor-pointer tw-items-center tw-justify-between tw-border-b tw-border-dusty-gray-300 tw-px-4 tw-py-2 lg:tw-hidden" data-v-006bc605><span data-v-006bc605> Research </span> <i aria-hidden="true" class="cstf cstf-angle-right tw-text-2xl" data-v-006bc605></i></div> <div class="lg:tw-hidden" style="display:none" data-v-006bc605><button class="tw-block tw-h-8 tw-w-full tw-text-left" data-v-006bc605><i aria-hidden="true" class="cstf cstf-angle-left tw-px-4 tw-text-2xl" data-v-006bc605></i></button> <a href="/research" class="tw-block tw-border-b tw-border-dusty-gray-300 tw-px-4 tw-py-2 tw-text-xl tw-font-bold tw-text-midnight-blue-500" data-v-006bc605> Research </a></div> <div data-test-id="navigation-submenu_research" class="menu-dropdown tw-bg-white lg:tw-absolute lg:tw-z-50 lg:tw-border-t-2 lg:tw-border-midnight-blue-500 lg:tw-shadow-lg" style="display:none" data-v-006bc605><div class="tw-flex tw-flex-col lg:tw-flex-row" data-v-006bc605><div data-test-id="navigation-submenuSection_research" class="menu-section tw-flex tw-flex-col tw-flex-wrap lg:tw-py-2 research" data-v-006bc605><a href="/research/cancer" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Cancer</a><a href="/research/cell-biology" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Cell Biology</a><a href="/research/developmental-biology-and-stem-cells" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Developmental Biology and Stem Cells</a><a href="/research/drug-discovery-solutions-powered-by-cst" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Drug Discovery Solutions Powered by CST</a><a href="/research/epigenetics" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Epigenetics</a><a href="/research/fibrosis" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Fibrosis</a><a href="/research/immunology-and-immuno-oncology" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Immunology and Immuno-Oncology</a><a href="/research/infectious-diseases" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Infectious Diseases / COVID-19</a><a href="/research/metabolism" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Metabolism</a><a href="/research/neuroscience" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Neuroscience</a><a href="/research/rna-regulation-and-translational-control" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>RNA Regulation and Translational Control</a></div> </div></div></li><li class="tw-group tw-px-[0.05em] lg:tw-relative nav-item-3" data-v-006bc605><a href="/pathways" data-test-id="navigation-main_pathways" class="navigation-main-link tw-hidden tw-p-4 lg:tw-block lg:tw-border-b-2 lg:tw-border-transparent lg:tw-py-2 lg:tw-px-0 lg:tw-uppercase lg:group-hover:tw-border-midnight-blue-500" data-v-006bc605><span class="tw-border-dusty-gray-300 lg:tw-border-r lg:tw-p-0 lg:tw-px-2 lg:group-last:tw-border-r-0" data-v-006bc605> Pathways </span></a> <div class="tw-flex tw-cursor-pointer tw-items-center tw-justify-between tw-border-b tw-border-dusty-gray-300 tw-px-4 tw-py-2 lg:tw-hidden" data-v-006bc605><span data-v-006bc605> Pathways </span> <i aria-hidden="true" class="cstf cstf-angle-right tw-text-2xl" data-v-006bc605></i></div> <div class="lg:tw-hidden" style="display:none" data-v-006bc605><button class="tw-block tw-h-8 tw-w-full tw-text-left" data-v-006bc605><i aria-hidden="true" class="cstf cstf-angle-left tw-px-4 tw-text-2xl" data-v-006bc605></i></button> <a href="/pathways" class="tw-block tw-border-b tw-border-dusty-gray-300 tw-px-4 tw-py-2 tw-text-xl tw-font-bold tw-text-midnight-blue-500" data-v-006bc605> Pathways </a></div> <div data-test-id="navigation-submenu_pathways" class="menu-dropdown tw-bg-white lg:tw-absolute lg:tw-z-50 lg:tw-border-t-2 lg:tw-border-midnight-blue-500 lg:tw-shadow-lg" style="display:none" data-v-006bc605><div class="tw-flex tw-flex-col lg:tw-flex-row" data-v-006bc605><div data-test-id="navigation-submenuSection_pathways" class="menu-section tw-flex tw-flex-col tw-flex-wrap lg:tw-py-2 pathways" data-v-006bc605><a href="/pathways/by-disease-area" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>By Disease Area</a><a href="/pathways/by-research-area" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>By Research Area</a><a href="/pathways/cellular-landscapes" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Cellular Landscapes</a></div> </div></div></li><li class="tw-group tw-px-[0.05em] lg:tw-relative nav-item-4" data-v-006bc605><a href="/services" data-test-id="navigation-main_services" class="navigation-main-link tw-hidden tw-p-4 lg:tw-block lg:tw-border-b-2 lg:tw-border-transparent lg:tw-py-2 lg:tw-px-0 lg:tw-uppercase lg:group-hover:tw-border-midnight-blue-500" data-v-006bc605><span class="tw-border-dusty-gray-300 lg:tw-border-r lg:tw-p-0 lg:tw-px-2 lg:group-last:tw-border-r-0" data-v-006bc605> Services </span></a> <div class="tw-flex tw-cursor-pointer tw-items-center tw-justify-between tw-border-b tw-border-dusty-gray-300 tw-px-4 tw-py-2 lg:tw-hidden" data-v-006bc605><span data-v-006bc605> Services </span> <i aria-hidden="true" class="cstf cstf-angle-right tw-text-2xl" data-v-006bc605></i></div> <div class="lg:tw-hidden" style="display:none" data-v-006bc605><button class="tw-block tw-h-8 tw-w-full tw-text-left" data-v-006bc605><i aria-hidden="true" class="cstf cstf-angle-left tw-px-4 tw-text-2xl" data-v-006bc605></i></button> <a href="/services" class="tw-block tw-border-b tw-border-dusty-gray-300 tw-px-4 tw-py-2 tw-text-xl tw-font-bold tw-text-midnight-blue-500" data-v-006bc605> Services </a></div> <div data-test-id="navigation-submenu_services" class="menu-dropdown tw-bg-white lg:tw-absolute lg:tw-z-50 lg:tw-border-t-2 lg:tw-border-midnight-blue-500 lg:tw-shadow-lg" style="display:none" data-v-006bc605><div class="tw-flex tw-flex-col lg:tw-flex-row" data-v-006bc605><div data-test-id="navigation-submenuSection_services" class="menu-section tw-flex tw-flex-col tw-flex-wrap lg:tw-py-2 services" data-v-006bc605><a href="/services/customized-and-carrier-free-formulation" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Carrier-free Custom Antibody Formulations</a><a href="/services/custom-peptides" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>AQUA and Custom Blocking Peptides</a><a href="/services/proteomics-analytical-services" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Proteomics Analytical Services</a><a href="/services/custom-conjugation-services" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Custom Conjugation & Labeling Services</a><a href="/services/bulk-quantities-and-lot-reservations" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Bulk Quantities and Lot Reservations</a></div> </div></div></li><li class="tw-group tw-px-[0.05em] lg:tw-relative nav-item-5" data-v-006bc605><a href="/learn-and-support" data-test-id="navigation-main_learn-support" class="navigation-main-link tw-hidden tw-p-4 lg:tw-block lg:tw-border-b-2 lg:tw-border-transparent lg:tw-py-2 lg:tw-px-0 lg:tw-uppercase lg:group-hover:tw-border-midnight-blue-500" data-v-006bc605><span class="tw-border-dusty-gray-300 lg:tw-border-r lg:tw-p-0 lg:tw-px-2 lg:group-last:tw-border-r-0" data-v-006bc605> Learn & Support </span></a> <div class="tw-flex tw-cursor-pointer tw-items-center tw-justify-between tw-border-b tw-border-dusty-gray-300 tw-px-4 tw-py-2 lg:tw-hidden" data-v-006bc605><span data-v-006bc605> Learn & Support </span> <i aria-hidden="true" class="cstf cstf-angle-right tw-text-2xl" data-v-006bc605></i></div> <div class="lg:tw-hidden" style="display:none" data-v-006bc605><button class="tw-block tw-h-8 tw-w-full tw-text-left" data-v-006bc605><i aria-hidden="true" class="cstf cstf-angle-left tw-px-4 tw-text-2xl" data-v-006bc605></i></button> <a href="/learn-and-support" class="tw-block tw-border-b tw-border-dusty-gray-300 tw-px-4 tw-py-2 tw-text-xl tw-font-bold tw-text-midnight-blue-500" data-v-006bc605> Learn & Support </a></div> <div data-test-id="navigation-submenu_learn-support" class="menu-dropdown tw-bg-white lg:tw-absolute lg:tw-z-50 lg:tw-border-t-2 lg:tw-border-midnight-blue-500 lg:tw-shadow-lg" style="display:none" data-v-006bc605><div class="tw-flex tw-flex-col lg:tw-flex-row" data-v-006bc605> <div data-test-id="navigation-submenuSection_education-resources" class="tw-flex tw-flex-col lg:tw-border-r lg:tw-py-2" data-v-006bc605><div class="tw-bg-dusty-gray-500 tw-px-2.5 tw-py-1.5 tw-text-xs tw-uppercase tw-text-white lg:tw-mx-2.5 lg:tw-mb-2.5" data-v-006bc605> Education & Resources </div>  <div class="menu-section tw-flex tw-flex-col lg:tw-flex-row education-resources" data-v-006bc605><div class="tw-flex tw-flex-col tw-flex-wrap" data-v-006bc605><a href="/learn-and-support/antibody-conjugates" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Antibody Conjugates</a><a href="https://blog.cellsignal.com/" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Blog</a><a href="/learn-and-support/conferences-and-events" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Conferences & Events</a><a href="/learn-and-support/control-treatments-by-target" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Control Treatments by Target</a><a href="/learn-and-support/pdf-download-page" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Downloadable Literature</a><a href="/learn-and-support/phosphositeplus-ptm-database" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>PhosphoSitePlus® PTM Database</a></div><div class="tw-flex tw-flex-col tw-flex-wrap" data-v-006bc605><a href="/learn-and-support/protein-domains-and-interactions" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Protein Domains & Interactions</a><a href="/learn-and-support/protein-kinases" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Protein Kinases</a><a href="/learn-and-support/publications-and-posters" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Publications & Research Posters</a><a href="/learn-and-support/reference-tables" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Reference Tables</a><a href="/learn-and-support/scientific-web-resources" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Scientific Web Resources</a><a href="/learn-and-support/videos-and-webinars" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Videos & Webinars</a></div></div></div><div data-test-id="navigation-submenuSection_troubleshooting-support" class="tw-flex tw-flex-col lg:tw-border-r lg:tw-py-2" data-v-006bc605><div class="tw-bg-dusty-gray-500 tw-px-2.5 tw-py-1.5 tw-text-xs tw-uppercase tw-text-white lg:tw-mx-2.5 lg:tw-mb-2.5" data-v-006bc605> Troubleshooting & Support </div>  <div class="menu-section tw-flex tw-flex-col lg:tw-flex-row troubleshooting-support" data-v-006bc605><div class="tw-flex tw-flex-col tw-flex-wrap" data-v-006bc605><a href="/learn-and-support/technical-support" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Technical Support</a><a href="/learn-and-support/support-information" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Contact Support</a><a href="/learn-and-support/troubleshooting" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Troubleshooting</a><a href="/learn-and-support/protocols" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Protocols</a><a href="/learn-and-support/technical-documentation" class="tw-block tw-border-b tw-border-l-4 tw-border-dusty-gray-300 tw-border-l-transparent tw-px-3 tw-py-2 hover:tw-border-l-midnight-blue-500 hover:tw-text-midnight-blue-500 lg:tw-mx-2.5 lg:tw-border-0 lg:tw-border-l-4 lg:tw-border-transparent lg:tw-p-2 lg:hover:tw-border-midnight-blue-500" data-v-006bc605>Technical Documentation</a></div></div></div></div></div></li><li class="tw-group tw-px-[0.05em] lg:tw-relative nav-item-6" data-v-006bc605><a href="/about-us" data-test-id="navigation-main_about-us" class="navigation-main-link tw-hidden tw-p-4 lg:tw-block lg:tw-border-b-2 lg:tw-border-transparent lg:tw-py-2 lg:tw-px-0 lg:tw-uppercase lg:group-hover:tw-border-midnight-blue-500" data-v-006bc605><span class="tw-border-dusty-gray-300 lg:tw-border-r lg:tw-p-0 lg:tw-px-2 lg:group-last:tw-border-r-0" data-v-006bc605> About us </span></a> <div class="tw-flex tw-cursor-pointer tw-items-center tw-justify-between tw-border-b tw-border-dusty-gray-300 tw-px-4 tw-py-2 lg:tw-hidden" data-v-006bc605><span data-v-006bc605> About us </span> <i aria-hidden="true" class="cstf cstf-angle-right tw-text-2xl" data-v-006bc605></i></div> <div class="lg:tw-hidden" style="display:none" data-v-006bc605><button class="tw-block tw-h-8 tw-w-full tw-text-left" data-v-006bc605><i aria-hidden="true" class="cstf cstf-angle-left tw-px-4 tw-text-2xl" data-v-006bc605></i></button> <a href="/about-us" class="tw-block tw-border-b tw-border-dusty-gray-300 tw-px-4 tw-py-2 tw-text-xl tw-font-bold tw-text-midnight-blue-500" 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"priceCurrency": "USD", "sku": "76143S", "availability": "http://schema.org/InStock", "itemCondition": "http://schema.org/NewCondition", "url": "" } }</script></div> <ol itemscope itemtype="http://schema.org/BreadcrumbList" class="breadcrumbs" data-v-29c18229> <li itemscope itemtype="http://schema.org/ListItem" itemprop="itemListElement" data-v-29c18229><a href="/browse" itemprop="item" data-v-29c18229><span itemprop="name" data-v-29c18229>Products</span></a> <meta itemprop="position" content="1" data-v-29c18229> <span class="divider" data-v-29c18229>/</span></li><li itemscope itemtype="http://schema.org/ListItem" itemprop="itemListElement" data-v-29c18229><a href="/browse?categories=Antibody%20Conjugates" itemprop="item" data-v-29c18229><span itemprop="name" data-v-29c18229>Antibody Conjugates</span></a> <meta itemprop="position" content="2" data-v-29c18229> <span class="divider" data-v-29c18229>/</span></li><li itemscope itemtype="http://schema.org/ListItem" itemprop="itemListElement" data-v-29c18229><span itemprop="name" data-v-29c18229>Phospho-SLP-76 (Ser376) (E3G9U) XP<sup>®</sup> Rabbit mAb (PE Conjugate)</span> <meta itemprop="position" content="3" data-v-29c18229> <meta itemprop="item" content="" data-v-29c18229></li></ol> <div class="recombinant-flag" data-v-0bc1a06e><div id="recombinant-flag-rectangle" title="Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing." data-v-0bc1a06e><span id="left-side" data-v-0bc1a06e>R</span> <span id="right-side" data-v-0bc1a06e>Recombinant</span></div> <div data-test-id="recombinant-tooltip" class="recombinant-tooltip" data-v-0bc1a06e><svg viewBox="0 0 512 512" width="1.2em" height="1.2em" data-v-0bc1a06e><path fill="currentColor" d="M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42s-42-18.804-42-42s18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z"></path></svg> <span data-test-id="recombinant-tooltip-text" class="recombinant-tooltiptext" data-v-0bc1a06e><b data-v-0bc1a06e>Recombinant:</b> Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing. </span></div> </div>  <div class="title" data-v-60b43a68><h1 class="tw-my-3 tw-text-2xl" data-v-60b43a68> <span data-v-60b43a68>Phospho-SLP-76 (Ser376) (E3G9U) XP<sup>®</sup> Rabbit mAb (PE Conjugate)</span> #76143 </h1></div>  <button class="citation-count tw-mb-2.5" data-v-257e77bc><i class="cstf cstf-quote-left" data-v-257e77bc></i> <span class="tw-text-lg tw-font-bold tw-text-black hover:tw-cursor-pointer hover:tw-underline hover:tw-decoration-black" data-v-257e77bc>Citations (0)</span></button> <div class="md:tw-flex md:tw-flex-col"><section class="tw-flex tw-flex-col tw-gap-8 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data-component="InPageNavigationPdpWrapper" templatecomponentdata="[object Object]"><div id="mobile-navigation" class="md:tw-hidden"><div class="tw-fixed tw-top-0 tw-left-0 tw-z-[50] tw-h-full tw-w-full tw-bg-[#ffffffe6]" style="display:none"><ul class="tw-fixed tw-right-7 tw-bottom-24" data-v-2b86a439></ul></div> <div class="tw-fixed tw-bottom-5 tw-right-5 tw-z-[50] tw-flex tw-items-center tw-gap-2"><p class="tw-text-base tw-text-dusty-gray-900" style="display:none">On Page Menu</p> <div class="tw-flex tw-h-14 tw-w-14 tw-items-center tw-justify-center tw-rounded-full tw-bg-danube tw-text-lg tw-text-white tw-shadow-[4px_4px_8px_0_rgba(0,0,0,.45)]"><i class="cstf cstf-protocols tw-text-3xl"></i></div></div></div> <div><div id="in-page-navigation" class="tw-w-full tw-bg-white tw-py-2 tw-z-10 tw-hidden tw-h-24 md:tw-block !tw-hidden" style="width:undefinedpx"><ul data-v-2b86a439></ul></div></div></section></div></section></div><div class="md:tw-flex md:tw-flex-col"><section class="tw-flex tw-flex-col tw-gap-8 md:tw-flex-row"><div class="tw-flex tw-flex-col md:tw-basis-2/3">  <div id="supporting-data" data-component="SupportingDataPdpWrapper" class="supporting-data tw-scroll-mt-52" data-v-f4c72556><h3 data-v-f4c72556>Supporting Data</h3> <table data-v-f4c72556><tbody data-v-f4c72556><tr data-v-f4c72556><td data-v-f4c72556>REACTIVITY</td> <td data-v-f4c72556>H M</td></tr><tr data-v-f4c72556><td data-v-f4c72556>SENSITIVITY</td> <td data-v-f4c72556>Endogenous</td></tr><tr data-v-f4c72556><td data-v-f4c72556>MW (kDa)</td> <td data-v-f4c72556></td></tr><tr data-v-f4c72556><td data-v-f4c72556>Source/Isotype</td> <td data-v-f4c72556>Rabbit IgG</td></tr></tbody></table> <div class="product-abbreviations" data-v-f4c72556><h5 data-v-f4c72556>Application Key:</h5> <ul data-v-f4c72556><li data-v-f4c72556><strong data-v-f4c72556>F</strong>-Flow Cytometry </li></ul> <h5 data-v-f4c72556>Species Cross-Reactivity Key:</h5> <ul data-v-f4c72556><li data-v-f4c72556><strong data-v-f4c72556>H</strong>-Human </li><li data-v-f4c72556><strong data-v-f4c72556>M</strong>-Mouse </li></ul></div></div><div data-component="ProductListPdpWrapper" data-v-27f14d6b></div><div data-component="ProductInformationPdpWrapper" class="product-information" data-v-7e9802d4><h2 data-v-7e9802d4>Product Information</h2> <div class="description-component" data-v-c8c44b8a data-v-7e9802d4><h3 data-v-c8c44b8a>Product Description</h3> <div class="tw-mb-3" data-v-c8c44b8a>This Cell Signaling Technology antibody is conjugated to phycoerythrin (PE) and tested in-house for direct flow cytometric analysis in human and mouse cells. This antibody is expected to exhibit the same species cross-reactivity as the unconjugated Phospho-SLP-76 (Ser376) (E3G9U) XP<sup>®</sup> Rabbit mAb #76384.</div> <table data-v-c8c44b8a><tbody data-v-c8c44b8a>      </tbody></table></div><div id="product-usage" class="tw-scroll-mt-52" data-v-181bd034 data-v-7e9802d4><div class="border-bottom" data-v-181bd034><h3 data-v-181bd034>Product Usage Information</h3>  <table class="tw-w-full tw-text-left tw-leading-8" data-v-181bd034><thead data-v-181bd034><tr data-v-181bd034><th data-v-181bd034>Application</th> <th data-v-181bd034>Dilution</th></tr></thead> <tbody data-v-181bd034><tr data-v-181bd034><td data-v-181bd034>Flow Cytometry (Fixed/Permeabilized)</td> <td data-v-181bd034>1:50</td></tr></tbody></table> </div>   <h3 data-v-181bd034>Storage</h3> <div data-v-181bd034>Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. <i>Do not aliquot the antibody. Protect from light. Do not freeze.</i></div></div><div id="protocols" class="tw-scroll-mt-52 protocol-component" data-v-bb7b31e0 data-v-7e9802d4><h3 data-v-bb7b31e0>Protocol</h3> <select class="tw-max-w-[16rem] tw-rounded-none tw-border-black tw-p-0" data-v-bb7b31e0><option selected data-v-bb7b31e0>Select your Protocol</option> <option value="407" data-v-bb7b31e0> Flow Cytometry (Fixed/Permeabilized) </option></select>    </div><div class="specificity-or-sensitivity" data-v-24efef65 data-v-7e9802d4><h3 data-v-24efef65>Specificity / Sensitivity</h3> <div class="specificity-description" data-v-24efef65>Phospho-SLP-76 (Ser376) (E3G9U) XP<sup>®</sup> Rabbit mAb (PE Conjugate) recognizes endogenous levels of SLP-76 protein only when phosphorylated at Ser376. Non-specific staining was observed in human stomach crypts by immunohistochemistry. Clone E3G9U is more sensitive by flow cytometry than clone D7S1K.</div> <br data-v-24efef65> <p class="tw-font-bold" data-v-24efef65>Species Reactivity:</p> <div data-v-24efef65>Human, Mouse</div> </div><div class="source-or-purification" data-v-3da27cd4 data-v-7e9802d4><h3 data-v-3da27cd4>Source / Purification</h3> <div data-v-3da27cd4>Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser376 of human SLP-76 protein.</div></div><div id="background" class="tw-scroll-mt-52" data-v-969bc690 data-v-7e9802d4><h3 data-v-969bc690>Background</h3> <div class="tw-mb-2.5" data-v-969bc690>SH2 domain-containing leukocyte protein of 76 kDa (SLP-76) is a hematopoietic adaptor protein that is important in multiple biochemical signaling pathways and necessary for T cell development and activation (1). ZAP-70 phosphorylates SLP-76 and LAT as a result of TCR ligation. SLP-76 has amino-terminal tyrosine residues followed by a proline-rich domain and a carboxy-terminal SH2 domain. Phosphorylation of Tyr113 and Tyr128 result in recruitment of the GEF Vav and the adaptor protein Nck (2). TCR ligation also leads to phosphorylation of Tyr145, which mediates an association between SLP-76 and Itk, which is accomplished in part via the proline-rich domain of SLP-76 and the SH3 domain of Itk (3). Furthermore, the proline-rich domain of SLP-76 binds to the SH3 domains of Grb2-like adaptor Gads (3,4). In resting cells, SLP-76 is predominantly in the cytosol. Upon TCR ligation, SLP-76 translocates to the plasma membrane and promotes the assembly of a multi-protein signaling complex that includes Vav, Nck, Itk, and PLCγ1 (1). The expression of SLP-76 is tightly regulated; the protein is detected at very early stages of thymocyte development, increases as thymocyte maturation progresses, and is reduced as cells mature to CD4<sup>+</sup> CD8<sup>+</sup> double-positive thymocytes (5).</div> <div data-v-969bc690><ol class="OneLinkNoTx tw-pl-10" data-v-969bc690><li data-test-id="background-references_'76143_GROUP_1'" data-v-969bc690><a href="http://www.ncbi.nlm.nih.gov/pubmed/12614362" target="_blank" class="anchorLink" data-v-969bc690>Clements, J.L. (2003) <cite>Immunol Rev</cite> 191, 211-9.</a></li><li data-test-id="background-references_'76143_GROUP_2'" data-v-969bc690><a href="http://www.ncbi.nlm.nih.gov/pubmed/9846482" target="_blank" class="anchorLink" data-v-969bc690>Bubeck Wardenburg, J. et al. (1998) <cite>Immunity</cite> 9, 607-16.</a></li><li data-test-id="background-references_'76143_GROUP_3'" data-v-969bc690><a href="http://www.ncbi.nlm.nih.gov/pubmed/10636929" target="_blank" class="anchorLink" data-v-969bc690>Bunnell, S.C. et al. (2000) <cite>J Biol Chem</cite> 275, 2219-30.</a></li><li data-test-id="background-references_'76143_GROUP_4'" data-v-969bc690><a href="http://www.ncbi.nlm.nih.gov/pubmed/10021361" target="_blank" class="anchorLink" data-v-969bc690>Liu, S.K. et al. (1999) <cite>Curr Biol</cite> 9, 67-75.</a></li><li data-test-id="background-references_'76143_GROUP_5'" data-v-969bc690><a href="http://www.ncbi.nlm.nih.gov/pubmed/9780153" target="_blank" class="anchorLink" data-v-969bc690>Clements, J.L. et al. (1998) <cite>J Immunol</cite> 161, 3880-9.</a></li></ol></div></div><div id="pathways" class="tw-scroll-mt-52 upstream-or-downstream-pathway-image" data-v-9177d07a data-v-7e9802d4></div><div class="database-links" data-v-08014b80 data-v-7e9802d4><h3 data-v-08014b80>Database Links</h3> <p data-v-08014b80> UniProt ID:  <a href="http://www.uniprot.org/uniprot/Q13094" target="_blank" class="anchorLink" data-v-08014b80> Q13094 </a></p> <br data-v-08014b80> <p data-v-08014b80> Entrez-Gene Id:  <a href="http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=full_report&list_uids=3937" target="_blank" class="anchorLink" data-v-08014b80> 3937 </a></p> <br data-v-08014b80> <button class="anchorLink" data-v-08014b80> View in <img src="//media.cellsignal.com/www/images/project-images/img/assets/PHosphosite_Icon.png" width="22" height="22" alt="PhosphoSitePlus<sup>®</sup> logo" class="tw-inline-block" data-v-08014b80>PhosphoSitePlus<sup data-v-08014b80>®</sup></button></div></div><div id="citations" data-component="CitationsPdpWrapper" class="tw-scroll-mt-52" data-v-ab599df2></div><div data-test-id="legalStatement-container" data-component="LegalStatementPdpWrapper" templatecomponentdata="[object Object]" class="tw-mb-10" data-v-7ca4e51c><div class="OneLinkNoTx legal-statement" data-v-7ca4e51c><h4>Limited Uses</h4><p>Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. 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