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[{"id":67244270,"identifier":"Attachment_67244270","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":48819486,"created_at":"2021-05-06T23:53:40.561-07:00","from_world_paper_id":170059094,"updated_at":"2024-11-23T13:00:01.905-08:00","_data":{"publisher":"Informa UK Limited","grobid_abstract":"Multivalent combination vaccines have reduced the number of injections and therefore improved vaccine acceptance, timeliness of administration and global coverage. The hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus/Haemophilus influenzae type b (DTPa-HBV-IPV/Hib; Infanrix hexa TM) vaccine, administered according to various schedules, is widely used for the primary vaccination of infants worldwide. In the current publication, we are presenting the immunogenicity and safety of 3 doses of DTPa-HBV-IPV/Hib vaccine when administered to Indian infants. 224 healthy infants (mean age 6.8 weeks) were vaccinated at 6-10-14 weeks (W) of age (n D 112) or 2-4-6 months (M) of age (n D 112). One month after the third vaccine dose, the seroprotection/seropositivity status against diphtheria, pertussis, tetanus, polio, hepatitis B and Hib antigens ranged from 98.6% to 100% in both groups. The vaccine response rate to the pertussis antigens ranged from 97% to 100%. Pain (6-10-14W group: 25.2%; 2-4-6M group: 13.4%) and fever (15.3% and; 15.2%, respectively) were the most frequently reported solicited local and general symptoms. Unsolicited adverse events were reported for 35.7% (6-10-14W group) and 22.3% (2-4-6M group) of subjects. No vaccine related serious adverse events were reported. In conclusion, the hexavalent DTPa-HBV-IPV/Hib vaccine was immunogenic and well tolerated, irrespective of the dosing schedule.","publication_date":"2016,,","publication_name":"Human Vaccines \u0026 Immunotherapeutics","grobid_abstract_attachment_id":"67244270"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Immunogenicity and safety of 3-dose primary vaccination with combined DTPa-HBV-IPV/Hib in Indian infants","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [41198478]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" 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ofDTPa, Hib, and OPV Vaccines in Infants Along With Commercial Hib Vaccines inComparison With Separate Safety and Reactogenicity of a Novel DTPa-HBV-IPV Combined Vaccine Given</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37298606" href="https://unimedizin-mainz.academia.edu/ClaudiusMeyer">Claudius Meyer</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Concomitant Administration ofDTPa, Hib, and OPV Vaccines in Infants Along With Commercial Hib Vaccines inComparison With Separate Safety and Reactogenicity of a Novel DTPa-HBV-IPV Combined Vaccine Given","attachmentId":42251428,"attachmentType":"pdf","work_url":"https://www.academia.edu/17527248/Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/17527248/Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="113807853" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/113807853/Safety_and_reactogenicity_of_DTPa_HBV_IPV_Hib_and_DTPa_IPV_I_Hib_vaccines_in_a_post_marketing_surveillance_setting">Safety and reactogenicity of DTPa-HBV-IPV/Hib and DTPa-IPV/I-Hib vaccines in a post-marketing surveillance setting</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="40792864" href="https://independent.academia.edu/KongPhua">Kong Phua</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Southeast Asian journal of tropical medicine and public health, 2011</p><p class="ds-related-work--abstract ds2-5-body-sm">Combination vaccines have been shown to improve the timeliness of vaccination and vaccine coverage. Safety and reactogenicity of combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus and Haemophilus influenzae type b vaccine (DTPa-IPV/Hib, Infanrix IPV+Hib, GlaxoSmithKline Biologicals) was assessed in two clinical studies. In Study A, 2,590 subjects received DTPa-IPV/Hib at 3, 4 and 5 months of age with a booster at 18 months. In Study B, 702 subjects received the same schedule but with DTPa-hepatitis B-IPV/Hib (DTPa-HBV-IPV/Hib, Infanrix hexa, GlaxoSmithKline Biologicals) vaccine administered at 5 months of age. Reactogenicity was assessed for four days after each dose using diary cards. Serious adverse events (SAEs) were assessed until 24 months of age. The vaccines were well tolerated. After primary vaccination, irritability was the most frequently reported grade 3 general symptom (0.8% of doses in both studies). Fever (axillary) &gt; 39 degrees C was infrequent ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Safety and reactogenicity of DTPa-HBV-IPV/Hib and DTPa-IPV/I-Hib vaccines in a post-marketing surveillance setting","attachmentId":110674882,"attachmentType":"pdf","work_url":"https://www.academia.edu/113807853/Safety_and_reactogenicity_of_DTPa_HBV_IPV_Hib_and_DTPa_IPV_I_Hib_vaccines_in_a_post_marketing_surveillance_setting","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/113807853/Safety_and_reactogenicity_of_DTPa_HBV_IPV_Hib_and_DTPa_IPV_I_Hib_vaccines_in_a_post_marketing_surveillance_setting"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="99497823" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/99497823/Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants">Safety and Reactogenicity of a Novel DTPa-HBV-IPV Combined Vaccine Given Along With Commercial Hib Vaccines inComparison With Separate Concomitant Administration ofDTPa, Hib, and OPV Vaccines in Infants</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="176086834" href="https://independent.academia.edu/ZeppFred">Fred Zepp</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Pediatrics, 2002</p><p class="ds-related-work--abstract ds2-5-body-sm">Objective. Combination vaccines simplify vaccine administration and have the potential to promote compliance and cost-effectiveness by decreasing the number of injections needed to immunize a child. The objective of this study was to assess the safety and reactogenicity of the diphtheria-tetanus toxoid-acellular pertussis-hepatitis B virus-inactivated polio virus (DTPa-HBV-IPV) vaccine when coadministered with different Haemophilus influenzae type B (Hib) vaccines in comparison with separate, commercially available, control vaccines in a 3-dose primary vaccination series. Methods. An open-label, randomized, parallel-group study in 5318 infants who were 8 to 16 weeks of age at enrollment was conducted in 90 centers in Germany. The incidence of adverse events that occurred in infants who received the DTPa-HBV-IPV candidate vaccine coadministered with 1 of 4 different Hib vaccines (given in separate sites; groups 1–4) was compared with the incidence that occurred in infants who receive...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Safety and Reactogenicity of a Novel DTPa-HBV-IPV Combined Vaccine Given Along With Commercial Hib Vaccines inComparison With Separate Concomitant Administration ofDTPa, Hib, and OPV Vaccines in Infants","attachmentId":100570559,"attachmentType":"pdf","work_url":"https://www.academia.edu/99497823/Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants","alternativeTracking":true}"><span 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href="https://www.academia.edu/73781061/Immunogenicity_and_Reactogenicity_of_DTPa_IPV_Hib_Vaccine_Co_administered_With_Hepatitis_B_Vaccine_for_Primary_and_Booster_Vaccination_of_Taiwanese_Infants">Immunogenicity and Reactogenicity of DTPa-IPV/Hib Vaccine Co-administered With Hepatitis B Vaccine for Primary and Booster Vaccination of Taiwanese Infants</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="217595099" href="https://independent.academia.edu/YuChiaHsieh">Yu Chia Hsieh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of the Formosan Medical Association, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity and Reactogenicity of DTPa-IPV/Hib Vaccine Co-administered With Hepatitis B Vaccine for Primary and Booster Vaccination of 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data-entity-id="4278383" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4278383/Primary_vaccination_of_infants_with_diphtheria_tetanus_acellular_pertussis_hepatitis_B_virus_inactivated_polio_virus_and_Haemophilus_influenzae_type_b_vaccines_given_as_either_separate_or_mixed_injections">Primary vaccination of infants with diphtheria-tetanus-acellular pertussis–hepatitis B virus– inactivated polio virus and Haemophilus influenzae type b vaccines given as either separate or mixed injections</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5193659" href="https://independent.academia.edu/OrtizEsteban">Esteban Ortiz</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Pediatrics, 2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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href="https://www.academia.edu/4278383/Primary_vaccination_of_infants_with_diphtheria_tetanus_acellular_pertussis_hepatitis_B_virus_inactivated_polio_virus_and_Haemophilus_influenzae_type_b_vaccines_given_as_either_separate_or_mixed_injections"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="125179240" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/125179240/Immunogenicity_and_safety_of_DTPW_HEPB_HIB_PRP_T_vaccine_Pentavac_in_infants_aged_2_7_months_a_post_marketing_phase_4_clinical_trial_study">Immunogenicity and safety of DTPW-HEPB-HIB (PRP-T) vaccine (Pentavac) in infants aged 2–7 months: a post marketing phase 4 clinical trial study</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="304551463" href="https://tums.academia.edu/ErfanehJafari">Erfaneh Jafari</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="11135871" href="https://tums.academia.edu/RezaAzizian">Reza Azizian, PhD</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Russian Journal of Infection and Immunity, 2024</p><p class="ds-related-work--abstract ds2-5-body-sm">Background. Vaccines play a critical role in safeguarding public health, particularly for children. It is imperative to proactively address safety concerns to uphold trust in their effectiveness and safety. Skepticism surrounding vaccines can have significant adverse effects on the overall well-being of the entire population, potentially leading to individuals opting out of vital vaccinations, thereby posing risks to public health. Thus, ensuring confidence in vaccine safety remains paramount. Materials and methods. This phase four clinical trial was conducted as a post-marketing study (PMS) on 2 to 7 month old healthy infants (N = 539) to evaluate immunity and safety of Indian pentavalent vaccine containing Diphtheria, Tetanus, Pertussis, Hepatitis B and Haemophilus influenza type b [DTPW-HEP B-HIB (PRP-T)/PENTAVAC] in four different centers at Tehran province. Blood samples were collected from eligible infants before receiving the vaccine (2 months of age) and 1 month after the third dose (7 months of age) to determine antibodies against all antigens in the pentavalent vaccine using ELISA. Results. The results indicated that the immune responses demonstrated seroprotection and protective antibody levels after three doses of the vaccine for Haemophilus influenza b, diphtheria, tetanus, hepatitis B virus and Bordetella pertussis were 99.1%, 98.7%, 99.8%, 99.4% and 69.6%, respectively. Statistical analysis showed that the P-value for all vaccine components was similar (P < 0.001). The five most common side effects reported were mild fever (10%), erythema at the vaccination site (9.1%), inflammation (4.3%), pain at the vaccination site (3.3%), and restlessness (2.6%). Conclusion. This study's findings demonstrated a significant increase in antibody levels against all five vaccine components. In light of these results, it can be concluded that the Pentavalent vaccine is not only effective in enhancing immunity against multiple diseases but also presents minimal risk of side effects in the study population. These findings contribute to the body of evidence supporting the safety and efficacy of vaccines, underscoring their crucial role in protecting public health.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity and safety of DTPW-HEPB-HIB (PRP-T) vaccine (Pentavac) in infants aged 2–7 months: a post marketing phase 4 clinical trial study","attachmentId":119268245,"attachmentType":"pdf","work_url":"https://www.academia.edu/125179240/Immunogenicity_and_safety_of_DTPW_HEPB_HIB_PRP_T_vaccine_Pentavac_in_infants_aged_2_7_months_a_post_marketing_phase_4_clinical_trial_study","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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data-author-id="67282412" href="https://independent.academia.edu/SvenArneSilfverdal">Sven Arne Silfverdal</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Human Vaccines & Immunotherapeutics, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunological persistence in 5 y olds previously vaccinated with hexavalent DTPa-HBV-IPV/Hib at 3, 5, and 11 months of age","attachmentId":73965746,"attachmentType":"pdf","work_url":"https://www.academia.edu/60589079/Immunological_persistence_in_5_y_olds_previously_vaccinated_with_hexavalent_DTPa_HBV_IPV_Hib_at_3_5_and_11_months_of_age","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/60589079/Immunological_persistence_in_5_y_olds_previously_vaccinated_with_hexavalent_DTPa_HBV_IPV_Hib_at_3_5_and_11_months_of_age"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="97724322" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/97724322/Immunogenicity_and_safety_of_an_indigenously_manufactured_reconstituted_pentavalent_DTwP_HBV_Hib_vaccine_in_comparison_with_a_foreign_competitor_following_primary_and_booster_immunization_in_Indian_children">Immunogenicity and safety of an indigenously manufactured reconstituted pentavalent (DTwP-HBV+Hib) vaccine in comparison with a foreign competitor following primary and booster immunization in Indian children</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="259596214" href="https://independent.academia.edu/vikasverma408">vikas verma</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Human Vaccines, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity and safety of an indigenously manufactured reconstituted pentavalent (DTwP-HBV+Hib) vaccine in comparison with a foreign competitor following primary and booster immunization in Indian children","attachmentId":99269023,"attachmentType":"pdf","work_url":"https://www.academia.edu/97724322/Immunogenicity_and_safety_of_an_indigenously_manufactured_reconstituted_pentavalent_DTwP_HBV_Hib_vaccine_in_comparison_with_a_foreign_competitor_following_primary_and_booster_immunization_in_Indian_children","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/97724322/Immunogenicity_and_safety_of_an_indigenously_manufactured_reconstituted_pentavalent_DTwP_HBV_Hib_vaccine_in_comparison_with_a_foreign_competitor_following_primary_and_booster_immunization_in_Indian_children"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="16795810" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/16795810/Comparison_of_the_reactogenicity_and_immunogenicity_of_a_combined_diphtheria_tetanus_acellular_pertussis_hepatitis_B_inactivated_polio_DTPa_HBV_IPV_vaccine_mixed_with_the_Haemophilus_influenzae_type_b_Hib_conjugate_vaccine_and_administered_as_a_single_injection_with_the_DTPa_IPV_Hib_and_">Comparison of the reactogenicity and immunogenicity of a combined diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated polio (DTPa–HBV–IPV) vaccine, mixed with the Haemophilus influenzae type b (Hib) conjugate vaccine and administered as a single injection, with the DTPa–IPV/Hib and...</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="26641596" href="https://independent.academia.edu/EugeniodeFrutos">Eugenio de Frutos</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36236693" href="https://independent.academia.edu/JosepMar%C3%A9s">Josep Marés</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2003</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Comparison of the reactogenicity and immunogenicity of a combined diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated polio (DTPa–HBV–IPV) vaccine, mixed with the Haemophilus influenzae type b (Hib) conjugate vaccine and administered as a single injection, with the DTPa–IPV/Hib and...","attachmentId":39187356,"attachmentType":"pdf","work_url":"https://www.academia.edu/16795810/Comparison_of_the_reactogenicity_and_immunogenicity_of_a_combined_diphtheria_tetanus_acellular_pertussis_hepatitis_B_inactivated_polio_DTPa_HBV_IPV_vaccine_mixed_with_the_Haemophilus_influenzae_type_b_Hib_conjugate_vaccine_and_administered_as_a_single_injection_with_the_DTPa_IPV_Hib_and_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/16795810/Comparison_of_the_reactogenicity_and_immunogenicity_of_a_combined_diphtheria_tetanus_acellular_pertussis_hepatitis_B_inactivated_polio_DTPa_HBV_IPV_vaccine_mixed_with_the_Haemophilus_influenzae_type_b_Hib_conjugate_vaccine_and_administered_as_a_single_injection_with_the_DTPa_IPV_Hib_and_"><span 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class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1998</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Safety and immunogenicity of a combined diphtheria-tetanus-acellular pertussis-hepatitis B vaccine administered according to two different primary vaccination schedules","attachmentId":74917132,"attachmentType":"pdf","work_url":"https://www.academia.edu/62049503/Safety_and_immunogenicity_of_a_combined_diphtheria_tetanus_acellular_pertussis_hepatitis_B_vaccine_administered_according_to_two_different_primary_vaccination_schedules","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" 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You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="4278382" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4278382/Immunogenicity_and_safety_of_DTaP_IPV_PRP_T_combination_vaccine_given_with_hepatitis_B_vaccine_a_randomized_open_label_trial">Immunogenicity and safety of DTaP-IPV/PRP-T combination vaccine given with hepatitis B vaccine: a randomized open-label trial</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5193659" href="https://independent.academia.edu/OrtizEsteban">Esteban Ortiz</a></div><p 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href="https://www.academia.edu/2495889/Immunogenicity_study_of_a_combined_diphtheria_tetanus_acellular_pertussis_inactivated_poliomyelitis_vaccine_used_to_reconstitute_a_freeze_dried_Haemophilus_influenzae_type_b_vaccine_DTaP_IPV_PRP_T_administered_simultaneously_with_a_hepatitis_B_vaccine_at_two_three_and_four_months_of_life"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="16626614" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" 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data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Safety, reactogenicity and immunogenicity of a combined hexavalent tetanus, diphtheria, acellular pertussis, hepatitis B, inactivated poliovirus vaccine and Haemophilus influenzae type b conjugate vaccine, for primary immunization of infants","attachmentId":42424809,"attachmentType":"pdf","work_url":"https://www.academia.edu/16626614/Safety_reactogenicity_and_immunogenicity_of_a_combined_hexavalent_tetanus_diphtheria_acellular_pertussis_hepatitis_B_inactivated_poliovirus_vaccine_and_Haemophilus_influenzae_type_b_conjugate_vaccine_for_primary_immunization_of_infants","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/16626614/Safety_reactogenicity_and_immunogenicity_of_a_combined_hexavalent_tetanus_diphtheria_acellular_pertussis_hepatitis_B_inactivated_poliovirus_vaccine_and_Haemophilus_influenzae_type_b_conjugate_vaccine_for_primary_immunization_of_infants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="27615805" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/27615805/Primary_and_booster_immunization_with_a_diphtheria_tetanus_acellular_pertussis_hepatitis_B_DTPa_HBV_and_Haemophilus_influenzae_type_b_Hib_vaccine_administered_separately_or_together_is_safe_and_immunogenic">Primary and booster immunization with a diphtheria, tetanus, acellular pertussis, hepatitis B (DTPa–HBV) and Haemophilus influenzae type b (Hib) vaccine administered separately or together is safe and immunogenic</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37075888" href="https://independent.academia.edu/KarinHardt">Karin Hardt</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Infectious Diseases, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Primary and booster immunization with a diphtheria, tetanus, acellular pertussis, hepatitis B (DTPa–HBV) and Haemophilus influenzae type b (Hib) vaccine administered separately or together is safe and immunogenic","attachmentId":47880484,"attachmentType":"pdf","work_url":"https://www.academia.edu/27615805/Primary_and_booster_immunization_with_a_diphtheria_tetanus_acellular_pertussis_hepatitis_B_DTPa_HBV_and_Haemophilus_influenzae_type_b_Hib_vaccine_administered_separately_or_together_is_safe_and_immunogenic","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/27615805/Primary_and_booster_immunization_with_a_diphtheria_tetanus_acellular_pertussis_hepatitis_B_DTPa_HBV_and_Haemophilus_influenzae_type_b_Hib_vaccine_administered_separately_or_together_is_safe_and_immunogenic"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="4" data-entity-id="89762773" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/89762773/Comparison_of_separate_and_mixed_administration_of_DTPw_HBV_and_Hib_vaccines_Immunogenicity_and_reactogenicity_profiles">Comparison of separate and mixed administration of DTPw-HBV and Hib vaccines: Immunogenicity and reactogenicity profiles</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="243267001" href="https://independent.academia.edu/KhinKhinWin3">Khin Khin Win</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Infectious Diseases, 1997</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="5" data-entity-id="48551652" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/48551652/A_New_DTPw_HBV_Hib_Vaccine_is_Immunogenic_and_Safe_when_Administered_According_to_the_EPI_Expanded_Programme_for_Immunization_Schedule_and_Following_Hepatitis_B_Vaccination_at_Birth">A New DTPw-HBV/Hib Vaccine is Immunogenic and Safe when Administered According to the EPI (Expanded Programme for Immunization) Schedule and Following Hepatitis B Vaccination at Birth</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43471878" href="https://independent.academia.edu/IngeLefevre">Inge Lefevre</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Human Vaccines, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A New DTPw-HBV/Hib Vaccine is Immunogenic and Safe when Administered According to the EPI (Expanded Programme for Immunization) Schedule and Following Hepatitis B Vaccination at Birth","attachmentId":67104258,"attachmentType":"pdf","work_url":"https://www.academia.edu/48551652/A_New_DTPw_HBV_Hib_Vaccine_is_Immunogenic_and_Safe_when_Administered_According_to_the_EPI_Expanded_Programme_for_Immunization_Schedule_and_Following_Hepatitis_B_Vaccination_at_Birth","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/48551652/A_New_DTPw_HBV_Hib_Vaccine_is_Immunogenic_and_Safe_when_Administered_According_to_the_EPI_Expanded_Programme_for_Immunization_Schedule_and_Following_Hepatitis_B_Vaccination_at_Birth"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="6" data-entity-id="15536449" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15536449/Reactogenicity_of_DTPa_HBV_Hib_vaccine_administered_as_a_single_injection_vs_DTPa_HBV_and_Hib_vaccines_administered_simultaneously_at_separate_sites_to_infants_at_2_4_and_6_months_of_age">Reactogenicity of DTPa-HBV/Hib vaccine administered as a single injection vs DTPa-HBV and Hib vaccines administered simultaneously at separate sites, to infants at 2, 4 and 6 months of age</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34691855" href="https://independent.academia.edu/Jos%C3%A9Garciasicilia">José Garcia-sicilia</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2001</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Reactogenicity of DTPa-HBV/Hib vaccine administered as a single injection vs DTPa-HBV and Hib vaccines administered simultaneously at separate sites, to infants at 2, 4 and 6 months of age","attachmentId":43111726,"attachmentType":"pdf","work_url":"https://www.academia.edu/15536449/Reactogenicity_of_DTPa_HBV_Hib_vaccine_administered_as_a_single_injection_vs_DTPa_HBV_and_Hib_vaccines_administered_simultaneously_at_separate_sites_to_infants_at_2_4_and_6_months_of_age","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/15536449/Reactogenicity_of_DTPa_HBV_Hib_vaccine_administered_as_a_single_injection_vs_DTPa_HBV_and_Hib_vaccines_administered_simultaneously_at_separate_sites_to_infants_at_2_4_and_6_months_of_age"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="7" data-entity-id="24644855" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/24644855/The_immunogenicity_and_safety_of_a_reduced_PRP_content_DTPw_HBV_Hib_vaccine_when_administered_according_to_the_accelerated_EPI_schedule">The immunogenicity and safety of a reduced PRP-content DTPw-HBV/Hib vaccine when administered according to the accelerated EPI schedule</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47742158" href="https://independent.academia.edu/FultonDSouza">Fulton D'Souza</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47506932" href="https://independent.academia.edu/ChatterjeeSukanta">Sukanta Chatterjee</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47576509" href="https://independent.academia.edu/BaldevBhatia">Baldev Bhatia</a></div><p class="ds-related-work--metadata ds2-5-body-xs">BMC Infectious Diseases, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The immunogenicity and safety of a reduced PRP-content DTPw-HBV/Hib vaccine when administered according to the accelerated EPI schedule","attachmentId":44971436,"attachmentType":"pdf","work_url":"https://www.academia.edu/24644855/The_immunogenicity_and_safety_of_a_reduced_PRP_content_DTPw_HBV_Hib_vaccine_when_administered_according_to_the_accelerated_EPI_schedule","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/24644855/The_immunogenicity_and_safety_of_a_reduced_PRP_content_DTPw_HBV_Hib_vaccine_when_administered_according_to_the_accelerated_EPI_schedule"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="8" data-entity-id="29154874" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/29154874/Immunogenicity_and_Reactogenicity_of_Diphtheria_Tetanus_Acellular_Pertussis_Hepatitis_B_Inactivated_Poliovirus_and_Haemophilus_influenzae_Type_B_Vaccines_Administered_Concomitantly_to_Infants_as_a_Three_dose_Primary_Course">Immunogenicity and Reactogenicity of Diphtheria—Tetanus—Acellular Pertussis—Hepatitis B—Inactivated Poliovirus and Haemophilus influenzae Type B Vaccines Administered Concomitantly to Infants as a Three-dose Primary Course</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="54905929" href="https://independent.academia.edu/ValterSundh">Valter Sundh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of the Formosan Medical Association, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity and Reactogenicity of Diphtheria—Tetanus—Acellular Pertussis—Hepatitis B—Inactivated Poliovirus and Haemophilus influenzae Type B Vaccines Administered Concomitantly to Infants as a Three-dose Primary Course","attachmentId":49599593,"attachmentType":"pdf","work_url":"https://www.academia.edu/29154874/Immunogenicity_and_Reactogenicity_of_Diphtheria_Tetanus_Acellular_Pertussis_Hepatitis_B_Inactivated_Poliovirus_and_Haemophilus_influenzae_Type_B_Vaccines_Administered_Concomitantly_to_Infants_as_a_Three_dose_Primary_Course","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/29154874/Immunogenicity_and_Reactogenicity_of_Diphtheria_Tetanus_Acellular_Pertussis_Hepatitis_B_Inactivated_Poliovirus_and_Haemophilus_influenzae_Type_B_Vaccines_Administered_Concomitantly_to_Infants_as_a_Three_dose_Primary_Course"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="9" data-entity-id="16980685" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/16980685/Immunogenicity_and_safety_of_a_DTaP_IPV_PRP_approximately_T_combination_vaccine_given_with_hepatitis_B_vaccine_a_randomized_open_label_trial">Immunogenicity and safety of a DTaP-IPV//PRP approximately T combination vaccine given with hepatitis B vaccine: a randomized open-label trial</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36500531" href="https://independent.academia.edu/MariaCapeding">Maria Capeding</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Bulletin of the World Health Organization, 2008</p><div class="ds-related-work--ctas"><button 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class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="10" data-entity-id="14115018" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14115018/Safety_and_immunogenicity_of_a_diphtheria_tetanus_and_acellular_pertussis_inactivated_poliovirus_vaccine_Haemophilus_influenzae_type_B_combination_vaccine_administered_to_Taiwanese_infants_at_2_4_and_6_months_of_age">Safety and immunogenicity of a diphtheria, tetanus, and acellular pertussis-inactivated poliovirus vaccine/Haemophilus influenzae type B combination vaccine administered to Taiwanese infants at 2, 4, and 6 months of age</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33115704" href="https://taiwan.academia.edu/LuanyinChang">Luan-yin Chang</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2003</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Safety and immunogenicity of a diphtheria, tetanus, and acellular pertussis-inactivated poliovirus vaccine/Haemophilus influenzae type B combination vaccine administered to Taiwanese infants at 2, 4, and 6 months of age","attachmentId":44589504,"attachmentType":"pdf","work_url":"https://www.academia.edu/14115018/Safety_and_immunogenicity_of_a_diphtheria_tetanus_and_acellular_pertussis_inactivated_poliovirus_vaccine_Haemophilus_influenzae_type_B_combination_vaccine_administered_to_Taiwanese_infants_at_2_4_and_6_months_of_age","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" 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