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} </style> <meta name="follow.it-verification-code-YjBieUhIbjlSaTlwVGJ3TCttMnFRWTNDY2NxN1pUUlpTN2hkZm9zZ1BSTHdJTE1NVFZmU2I5MkF4Z1RPK3FqN0lNR2Vjd1l3NVE3eC9hVzJCR092MUhxNVY3ek52SlpyQ2kvdm9MUXViT0FYdSs1eW1YeWtYdEg3RFRqNm1lMEV8bzBEc0VDNjlTMzdxb3FrOUdNYzJrbmxEbEtaQlI5WTNGQTZIc3VQQVo5ND0=" content="d4BS8a1CMehBt5r4ASFd"/> <meta name="viewport" content="width=device-width, initial-scale=1"><meta property="og:image:secure_url" content="https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/03/201607Pasted-Graphic-1.png" data-id="sfsi-plus"/><meta property="og:image:type" content="" data-id="sfsi-plus"/><meta property="og:image:width" content="720" data-id="sfsi-plus"/><meta property="og:image:height" content="477" data-id="sfsi-plus"/><meta property="og:description" content="[vc_row gap=15][vc_column width=3/4][vc_column_text]TRON wurde als selbstständiges Institut an der Schnittstelle zwischen Wissenschaft und Wirtschaft gegründet, um die gegenwärtig noch unzulängliche Behandlung von Krankheiten, die mit einer deregulierten Immunität in Verbindung stehen, voranzutreiben. Krankheiten wie Krebs, Allergien, Autoimmunkrankheiten und chronische Infektionen sind weit verbreitet, und ihre Häufigkeit nimmt konstant zu. Bei Krebs und chronischen Infektionen ist das Immunsystem nicht mehr in der Lage, die Last der Erkrankung zu kontrollieren; die Pathogenese von Allergien und Autoimmunkrankheiten ist dagegen durch eine unkontrollierte oder überschießende Immunreaktionen gekennzeichnet. [/vc_column_text][vc_empty_space height=25px][vc_row_inner gap=15][vc_column_inner width=2/3][vc_column_text]Ein Forschungsschwerpunkt am TRON befasst sich mit der Entwicklung gezielter Immuntherapien. Derartige Behandlungsansätze sind zurzeit die innovativsten Möglichkeiten für die Therapie der oben genannten Krankheiten. Impfstoffe, die aktiv modifizierte Immunreaktionen gegen Krebs und Infektionskrankheiten hervorrufen, oder auch die maßgeschneiderte Suppression des Immunsystems, um Allergien und Autoimmunkrankheiten zu behandeln, sind vielversprechende Behandlungsmöglichkeiten. Die Forschungsgruppen am TRON leisten einen Beitrag zur Entwicklung innovativer rekombinanter Impfstoffe, monoklonaler Antikörper, sowie adoptiver Zell- und Gentherapien.[/vc_column_text][/vc_column_inner][vc_column_inner width=1/3][vc_single_image image=7729 img_size=full][/vc_column_inner][/vc_row_inner][vc_empty_space height=25px][vc_column_text]Auch wenn in den letzten Jahrzehnten bedeutende Forschritte erzielt worden sind, so gibt es doch immer wieder neue Herausforderungen. Als Folge der demographischen Entwicklung steigt auch die Häufigkeit von Krebs; in den Industrienationen ist Krebs die Ursache jedes vierten Todesfalles. Durch die molekulare Heterogenität von Krebs kommen die momentan verfügbaren Therapiemöglichkeiten weniger als 25% der betroffenen Patienten zugute. Mit der individualisierten Medizin können Ärzte nun die Behandlung auf die individuellen Bedürfnisse der Patienten abstimmen. Dieser wegweisende Ansatz kann zur Verbesserung der Behandlungseffizienz beitragen, aber auch die mit der Arzneimittelentwicklung und medizinischen Versorgung verbundenen Kosten reduzieren. Die Erforschung neuer Biomarker am TRON ist ein wichtiger Beitrag in diesem Bereich, denn diese Moleküle liefern wertvolle Informationen sowohl für die Diagnose als auch die Therapie von Erkrankungen. So kann die Erkrankung genau definiert und eine spezifische Therapie ausgewählt werden. Zudem ist TRON in den Technologien und Methoden, die für die Profilierung klinischer Proben notwendig sind, spezialisiert. Dazu zählen z.B. „Next Generation Sequencing“-Plattformen, die Auswertung großer Datenmengen (Data Mining) und die Analyse von Ergebnissen aus der Grundlagen- und klinischen Forschung.[/vc_column_text][/vc_column][vc_column width=1/4][vc_basic_grid post_type=page max_items=10 element_width=12 gap=15 item=6316 grid_id=vc_gid:1490004547525-cda98b9c-fa40-8 taxonomies=26][/vc_column][/vc_row]" data-id="sfsi-plus"/><meta property="og:url" content="https://web.archive.org/web/20210320060939/https://tron-mainz.de/de/forschung/fokus/" data-id="sfsi-plus"/><meta property="og:title" content="Fokus" data-id="sfsi-plus"/><link rel="alternate" hreflang="en-US" href="https://web.archive.org/web/20210320060939/https://tron-mainz.de/research/focus/"><link rel="alternate" hreflang="de-DE" href="https://web.archive.org/web/20210320060939/https://tron-mainz.de/de/forschung/fokus/">  <style type="text/css"> #logo .site-title, #logo .site-description { display:none; } body 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menu-item-object-page menu-item-9296"><a href="https://web.archive.org/web/20210320060939/https://tron-mainz.de/de/2021-2/"><span>2021</span></a></li> <li id="menu-item-8999" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-8999"><a href="https://web.archive.org/web/20210320060939/https://tron-mainz.de/de/2020-2/"><span>2020</span></a></li> <li id="menu-item-8791" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-8791"><a href="https://web.archive.org/web/20210320060939/https://tron-mainz.de/de/2019-2/"><span>2019</span></a></li> <li id="menu-item-8461" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-8461"><a href="https://web.archive.org/web/20210320060939/https://tron-mainz.de/de/2018-2/"><span>2018</span></a></li> <li id="menu-item-7853" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-7853"><a href="https://web.archive.org/web/20210320060939/https://tron-mainz.de/de/2017-2/"><span>2017</span></a></li> <li id="menu-item-6823" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-6823"><a href="https://web.archive.org/web/20210320060939/https://tron-mainz.de/de/2016-2/"><span>2016</span></a></li> <li id="menu-item-6822" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-6822"><a href="https://web.archive.org/web/20210320060939/https://tron-mainz.de/de/2015-2/"><span>2015</span></a></li> <li id="menu-item-6821" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-6821"><a href="https://web.archive.org/web/20210320060939/https://tron-mainz.de/de/2014-2/"><span>2014</span></a></li> <li id="menu-item-6820" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-6820"><a href="https://web.archive.org/web/20210320060939/https://tron-mainz.de/de/publications/2013-2/"><span>2013</span></a></li> <li 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Wissenschaftsallianz</span></a></li> </ul> </li> </ul></div> <div class="side-nav"> <ul class="nav-search"> <li> <a class="search-contents" href="#"></a> <ul> <li> <div class="widget widget_search"><div class="search_main"> <form method="get" class="searchform" action="https://web.archive.org/web/20210320060939/https://tron-mainz.de/de/"> <input type="text" class="field s" name="s" value="Search..." onfocus="if (this.value == 'Search...') {this.value = '';}" onblur="if (this.value == '') {this.value = 'Search...';}"/> <button type="submit" class="fa fa-search submit" name="submit" value="Search"></button> </form> <div class="fix"></div> </div></div> </li> </ul> </li> </ul> </div> </section> <a href="#top" class="nav-close"> <i class="fa fa-times"></i> <span>Return to Content</span> </a> </nav> </div> </header> </div>  <div id="content" class="col-full"> <div id="main-sidebar-container">  <section id="main"> <article class="post-6757 page type-page status-publish has-post-thumbnail hentry category-research"> <header> <h1 class="title entry-title">Fokus</h1> </header> <section class="entry"> <div class="vc_row wpb_row vc_row-fluid vc_column-gap-15 mpc-row"><div class="wpb_column vc_column_container vc_col-sm-9 mpc-column"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element "> <div class="wpb_wrapper"> <p>TRON wurde als selbstständiges Institut an der Schnittstelle zwischen Wissenschaft und Wirtschaft gegründet, um die gegenwärtig noch unzulängliche Behandlung von Krankheiten, die mit einer deregulierten Immunität in Verbindung stehen, voranzutreiben. Krankheiten wie Krebs, Allergien, Autoimmunkrankheiten und chronische Infektionen sind weit verbreitet, und ihre Häufigkeit nimmt konstant zu. Bei Krebs und chronischen Infektionen ist das Immunsystem nicht mehr in der Lage, die Last der Erkrankung zu kontrollieren; die Pathogenese von Allergien und Autoimmunkrankheiten ist dagegen durch eine unkontrollierte oder überschießende Immunreaktionen gekennzeichnet.</p> </div> </div> <div class="vc_empty_space" style="height: 25px"><span class="vc_empty_space_inner"></span></div><div class="vc_row wpb_row vc_inner vc_row-fluid vc_column-gap-15 mpc-row"><div class="wpb_column vc_column_container vc_col-sm-8 mpc-column" data-column-id="mpc_column-61605591a38e6eb"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element "> <div class="wpb_wrapper"> <p>Ein Forschungsschwerpunkt am TRON befasst sich mit der Entwicklung gezielter Immuntherapien. Derartige Behandlungsansätze sind zurzeit die innovativsten Möglichkeiten für die Therapie der oben genannten Krankheiten. Impfstoffe, die aktiv modifizierte Immunreaktionen gegen Krebs und Infektionskrankheiten hervorrufen, oder auch die maßgeschneiderte Suppression des Immunsystems, um Allergien und Autoimmunkrankheiten zu behandeln, sind vielversprechende Behandlungsmöglichkeiten. Die Forschungsgruppen am TRON leisten einen Beitrag zur Entwicklung innovativer rekombinanter Impfstoffe, monoklonaler Antikörper, sowie adoptiver Zell- und Gentherapien.</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-4 mpc-column"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img width="720" height="477" src="https://web.archive.org/web/20210320060939im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/03/201607Pasted-Graphic-1.png" class="vc_single_image-img attachment-full" alt="" loading="lazy" srcset="https://web.archive.org/web/20210320060939im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/03/201607Pasted-Graphic-1.png 720w, https://web.archive.org/web/20210320060939im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/03/201607Pasted-Graphic-1-300x199.png 300w" sizes="(max-width: 720px) 100vw, 720px"></div> </figure> </div> </div></div></div></div><div class="vc_empty_space" style="height: 25px"><span class="vc_empty_space_inner"></span></div> <div class="wpb_text_column wpb_content_element "> <div class="wpb_wrapper"> <p>Auch wenn in den letzten Jahrzehnten bedeutende Forschritte erzielt worden sind, so gibt es doch immer wieder neue Herausforderungen. Als Folge der demographischen Entwicklung steigt auch die Häufigkeit von Krebs; in den Industrienationen ist Krebs die Ursache jedes vierten Todesfalles. Durch die molekulare Heterogenität von Krebs kommen die momentan verfügbaren Therapiemöglichkeiten weniger als 25% der betroffenen Patienten zugute.</p> <p>Mit der individualisierten Medizin können Ärzte nun die Behandlung auf die individuellen Bedürfnisse der Patienten abstimmen. Dieser wegweisende Ansatz kann zur Verbesserung der Behandlungseffizienz beitragen, aber auch die mit der Arzneimittelentwicklung und medizinischen Versorgung verbundenen Kosten reduzieren. Die Erforschung neuer Biomarker am TRON ist ein wichtiger Beitrag in diesem Bereich, denn diese Moleküle liefern wertvolle Informationen sowohl für die Diagnose als auch die Therapie von Erkrankungen. So kann die Erkrankung genau definiert und eine spezifische Therapie ausgewählt werden. Zudem ist TRON in den Technologien und Methoden, die für die Profilierung klinischer Proben notwendig sind, spezialisiert. Dazu zählen z.B. &bdquo;Next Generation Sequencing“-Plattformen, die Auswertung großer Datenmengen (Data Mining) und die Analyse von Ergebnissen aus der Grundlagen- und klinischen Forschung.</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-3 mpc-column"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="vc_grid-container-wrapper vc_clearfix"> <div class="vc_grid-container vc_clearfix wpb_content_element vc_basic_grid" data-initial-loading-animation="fadeIn" data-vc-grid-settings="{"page_id":6757,"style":"all","action":"vc_get_vc_grid_data","shortcode_id":"1490004547525-cda98b9c-fa40-8","tag":"vc_basic_grid"}" data-vc-request="https://tron-mainz.de/de/wp-admin/admin-ajax.php" data-vc-post-id="6757" data-vc-public-nonce="660a59436e"> <style data-type="vc_shortcodes-custom-css">.vc_custom_1486924919262{padding-top: 15px !important;padding-right: 15px !important;padding-bottom: 15px !important;padding-left: 15px 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