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} </style> <meta name="follow.it-verification-code-YjBieUhIbjlSaTlwVGJ3TCttMnFRWTNDY2NxN1pUUlpTN2hkZm9zZ1BSTHdJTE1NVFZmU2I5MkF4Z1RPK3FqN0lNR2Vjd1l3NVE3eC9hVzJCR092MUhxNVY3ek52SlpyQ2kvdm9MUXViT0FYdSs1eW1YeWtYdEg3RFRqNm1lMEV8bzBEc0VDNjlTMzdxb3FrOUdNYzJrbmxEbEtaQlI5WTNGQTZIc3VQQVo5ND0=" content="d4BS8a1CMehBt5r4ASFd"/> <meta name="viewport" content="width=device-width, initial-scale=1"><meta property="og:image:secure_url" content="https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/hla_tcr2.png" data-id="sfsi-plus"/><meta property="og:image:type" content="" data-id="sfsi-plus"/><meta property="og:image:width" content="1920" data-id="sfsi-plus"/><meta property="og:image:height" content="1080" data-id="sfsi-plus"/><meta property="og:description" content="[vc_row gap=15][vc_column width=3/4][vc_row_inner][vc_column_inner width=2/3][vc_column_text] Die Immuntherapie von Krebs ist einer der Hauptschwerpunkte des TRON. Dabei werden Komponenten des Immunsystems so moduliert, dass sie zur effektiven Behandlung der Krebserkrankung beitragen. In Zusammenarbeit mit industriellen Partnern hat TRON leistungsfähige Plattformen für die Entwicklung der nachfolgend beschriebenen Immuntherapien entwickelt. [/vc_column_text][/vc_column_inner][vc_column_inner width=1/3][vc_single_image image=7575 img_size=full][/vc_column_inner][/vc_row_inner][vc_empty_space height=50][vc_tta_accordion style=flat shape=square color=white spacing=15 active_section=0 no_fill=true collapsible_all=true][vc_tta_section title=Impfstoffe tab_id=1484240334868-bac1d1e2-273f][vc_row_inner gap=15][vc_column_inner width=2/3][vc_column_text] Impfstoffe werden seit Jahrhunderten zur aktiven Immunisierung gegen Infektionskrankheiten angewendet. Sogenannte präventive Impfstoffe werden zur Vorbeugung vor einer Infektionskrankheit verwendet; sie rufen im Rezipienten eine antigenspezifische Immunität hervor und bieten ihm so Schutz bei nachfolgenden Infektionen. Für unseren Kampf gegen Krebs benötigen wir eine andere Form von Impfstoff, d.h. einen „therapeutischen“ Krebsimpfstoff, mit dem eine bereits vorhandene Krankheit behandelt oder geheilt werden kann. Therapeutische Impfstoffe aktivieren die Zellen des Immunsystems, sodass Krebszellen als „körperfremd“ erkannt und letztlich zerstört werden. Durch Stimulation der tumorantigenspezifischen Immunität kann ein therapeutischer Krebsimpfstoff Krebszellen effektiv eliminieren, ohne dabei die gesunden patienteneigenen Zellen anzugreifen. Am TRON untersuchen wir unterschiedliche therapeutische Krebsimpfstoffe in Bezug auf ihre Effizienz in der Krebsbekämpfung. Unser Schwerpunkt liegt hierbei auf der mRNA-basierten Anti-Tumor-Impfung, die sich in der Präklinik als ein sicheres und effektives Instrument zur Krebsbekämpfung erwiesen hat. Wir wollen nun diesen Ansatz sowie andere zurzeit am TRON getestete Impfstrategien mit herkömmlichen Krebstherapien verbinden. Außerdem glauben wir, dass individualisierte Krebsimpfstoffe, die auf patientenspezifische Tumorsignaturen ausgerichtet sind, ebenfalls Kandidaten für eine erfolgreiche Krebsimmuntherapie sind. [/vc_column_text][/vc_column_inner][vc_column_inner width=1/3][vc_single_image image=7252 img_size=full][/vc_column_inner][/vc_row_inner][/vc_tta_section][vc_tta_section title=Zelltherapie tab_id=1484240334911-615bfd96-bf35][vc_row_inner gap=15][vc_column_inner width=2/3][vc_column_text]Zelltherapien gehören zu den erfolgreichsten innovativen Ansätzen in der individualisierten Behandlung von Krebs und zu einem weiterhin wichtigen Forschungsfeld. 2011 kam es zur Zulassung der ersten Tumorvakzine auf der Basis dendritischer Zellen zur Therapie von kastrationsresistentem Prostatakrebs im fortgeschrittenen Stadium durch die amerikanische Zulassungsbehörde FDA. Unabhängige Forscher aus aller Welt haben bereits vielversprechende Resultate beim adoptiven Transfer von tumorspezifischen Lymphozyten erzielt. Wissenschaftler am TRON entwickeln eigene Technologien für die Klonierung und Charakterisierung von antigenspezifischen Zellrezeptoren. Ein Expertenteam am TRON kloniert unter Verwendung einer etablierten Technologieplattform neue T-Zell-Rezeptoren (TZR). TRON führt auch F&E-Projekte in Zusammenarbeit mit anderen Einrichtungen durch. Die gegenwärtige Forschung konzentriert sich vor allem auf Möglichkeiten, den Phänotyp von T-Lymphozyten nach dem Transfer von TZR-Genen zu kontrollieren und zu modifizieren. Unsere Zielsetzung sind bessere therapeutische Ansätze und dafür entwickeln wir genetisch modifizierte Lymphozyten für die Behandlung von schweren Krankheiten.[/vc_column_text][/vc_column_inner][vc_column_inner width=1/3][vc_single_image image=7443 img_size=full][/vc_column_inner][/vc_row_inner][/vc_tta_section][vc_tta_section title=Kombinationstherapien tab_id=1484240433002-25c43a54-1e9d][vc_row_inner gap=15][vc_column_inner width=2/3][vc_column_text]Wir sind der Auffassung, dass Monotherapien nur der erste Schritt sind, um effektive Anti-Tumor-Effekte mit immuntherapeutischen Ansätzen zu erzielen. Das Potenzial von Immuntherapien kann nur durch die Kombination von Strahlentherapie, Chemotherapie und unterschiedlichen Immuntherapien voll ausgeschöpft werden. Daher untersuchen wir zunächst unterschiedliche Substanzen, ob und wie sie die Mikroumgebung von Tumoren modulieren, sowie ihren Einfluss auf die adaptive und angeborene Immunität. Die ausgewählten Substanzen werden dann mit etablierten Immuntherapeutika kombiniert und in in vivo-Experimenten validiert. Die Kombination von in vitro-Screening-Methoden und der in vivo-Validierung erlaubt es uns, umfassende vorklinische Daten zu generieren, die dann klinisch getestet werden können.[/vc_column_text][/vc_column_inner][vc_column_inner width=1/3][vc_single_image image=7256 img_size=full][/vc_column_inner][/vc_row_inner][/vc_tta_section][vc_tta_section title=Nanopartikel tab_id=1484240471918-05f08ace-4e1e][vc_row_inner gap=15][vc_column_inner width=2/3][vc_column_text] Nanopartikel-Wirkstoffträger sind kolloidale Präparationen von Partikeln und Molekülaggregaten in einem Größenbereich von 1 bis ca. 1000 nm. Liposomen zählen zu den heute am besten etablierten Wirkstoffträgern. In den letzten Jahren wurden zahlreiche Nanopartikel-Wirkstoffträger aus der Grundlagenforschung heraus bis in die späte klinische Erprobung und sogar bis hin zur Patientenversorgung weiterentwickelt. Am TRON entwickeln wir lipidbasierte und andere Nanopartikel-Formulierungen als Wirkstoffträger, von kleinen Molekülen bis hin zu hochmolekularen Nukleinsäuren. Wir bieten maßgeschneiderte Formulierungen für die Abgabe der von den Arzneimittel-Entwicklungsabteilungen des TRON hergestellten Substanzen an. Dazu zählen auch Lipoplex-Formulierungen, die sich besonders für die systemische Verabreichung von mRNA eignen. Zudem liefern wir auch Nanopartikel-Formulierungen als Referenzen für Forschungsprojekte; unter anderem fluoreszenz-(NIR) markierte Liposomen mit definierter Beladung und molekularer Zusammensetzung oder auch nach Kundenwunsch für definierte Anwendungen hergestellte Transfektionsreagenzien. 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class="side-nav"> <ul class="nav-search"> <li> <a class="search-contents" href="#"></a> <ul> <li> <div class="widget widget_search"><div class="search_main"> <form method="get" class="searchform" action="https://web.archive.org/web/20210320060930/https://tron-mainz.de/de/"> <input type="text" class="field s" name="s" value="Search..." onfocus="if (this.value == 'Search...') {this.value = '';}" onblur="if (this.value == '') {this.value = 'Search...';}"/> <button type="submit" class="fa fa-search submit" name="submit" value="Search"></button> </form> <div class="fix"></div> </div></div> </li> </ul> </li> </ul> </div> </section> <a href="#top" class="nav-close"> <i class="fa fa-times"></i> <span>Return to Content</span> </a> </nav> </div> </header> </div>  <div id="content" class="col-full"> <div id="main-sidebar-container">  <section id="main"> <article class="post-6759 page type-page status-publish has-post-thumbnail hentry category-research"> <header> <h1 class="title entry-title">Immuntherapie</h1> </header> <section class="entry"> <div class="vc_row wpb_row vc_row-fluid vc_column-gap-15 mpc-row"><div class="wpb_column vc_column_container vc_col-sm-9 mpc-column"><div class="vc_column-inner"><div class="wpb_wrapper"><div class="vc_row wpb_row vc_inner vc_row-fluid mpc-row"><div class="wpb_column vc_column_container vc_col-sm-8 mpc-column" data-column-id="mpc_column-926055919a80bd7"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element "> <div class="wpb_wrapper"> <div class="su-column su-column-size-2-3"> <div class="su-column-inner su-clearfix"> <p>Die Immuntherapie von Krebs ist einer der Hauptschwerpunkte des TRON. Dabei werden Komponenten des Immunsystems so moduliert, dass sie zur effektiven Behandlung der Krebserkrankung beitragen. In Zusammenarbeit mit industriellen Partnern hat TRON leistungsfähige Plattformen für die Entwicklung der nachfolgend beschriebenen Immuntherapien entwickelt.</p> </div> </div> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-4 mpc-column"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img width="1920" height="1080" src="https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/hla_tcr2.png" class="vc_single_image-img attachment-full" alt="" loading="lazy" srcset="https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/hla_tcr2.png 1920w, https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/hla_tcr2-300x169.png 300w, https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/hla_tcr2-768x432.png 768w, https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/hla_tcr2-1024x576.png 1024w" sizes="(max-width: 1920px) 100vw, 1920px"></div> </figure> </div> </div></div></div></div><div class="vc_empty_space" style="height: 50px"><span class="vc_empty_space_inner"></span></div><div class="vc_tta-container" data-vc-action="collapseAll"><div class="vc_general vc_tta vc_tta-accordion vc_tta-color-white vc_tta-style-flat vc_tta-shape-square vc_tta-spacing-15 vc_tta-controls-align-left vc_tta-o-no-fill vc_tta-o-all-clickable"><div class="vc_tta-panels-container"><div class="vc_tta-panels"><div class="vc_tta-panel" id="1484240334868-bac1d1e2-273f" data-vc-content=".vc_tta-panel-body"><div class="vc_tta-panel-heading"><h4 class="vc_tta-panel-title vc_tta-controls-icon-position-left"><a href="#1484240334868-bac1d1e2-273f" data-vc-accordion data-vc-container=".vc_tta-container"><span class="vc_tta-title-text">Impfstoffe</span><i class="vc_tta-controls-icon vc_tta-controls-icon-plus"></i></a></h4></div><div class="vc_tta-panel-body"><div class="vc_row wpb_row vc_inner vc_row-fluid vc_column-gap-15 mpc-row"><div class="wpb_column vc_column_container vc_col-sm-8 mpc-column"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element "> <div class="wpb_wrapper"> <div class="halfesSlideshowsmall"> <p>Impfstoffe werden seit Jahrhunderten zur aktiven Immunisierung gegen Infektionskrankheiten angewendet. Sogenannte präventive Impfstoffe werden zur Vorbeugung vor einer Infektionskrankheit verwendet; sie rufen im Rezipienten eine antigenspezifische Immunität hervor und bieten ihm so Schutz bei nachfolgenden Infektionen.</p> <p>Für unseren Kampf gegen Krebs benötigen wir eine andere Form von Impfstoff, d.h. einen &bdquo;therapeutischen“ Krebsimpfstoff, mit dem eine bereits vorhandene Krankheit behandelt oder geheilt werden kann. Therapeutische Impfstoffe aktivieren die Zellen des Immunsystems, sodass Krebszellen als &bdquo;körperfremd“ erkannt und letztlich zerstört werden. Durch Stimulation der tumorantigenspezifischen Immunität kann ein therapeutischer Krebsimpfstoff Krebszellen effektiv eliminieren, ohne dabei die gesunden patienteneigenen Zellen anzugreifen.</p> <p>Am TRON untersuchen wir unterschiedliche therapeutische Krebsimpfstoffe in Bezug auf ihre Effizienz in der Krebsbekämpfung. Unser Schwerpunkt liegt hierbei auf der mRNA-basierten Anti-Tumor-Impfung, die sich in der Präklinik als ein sicheres und effektives Instrument zur Krebsbekämpfung erwiesen hat. Wir wollen nun diesen Ansatz sowie andere zurzeit am TRON getestete Impfstrategien mit herkömmlichen Krebstherapien verbinden. Außerdem glauben wir, dass individualisierte Krebsimpfstoffe, die auf patientenspezifische Tumorsignaturen ausgerichtet sind, ebenfalls Kandidaten für eine erfolgreiche Krebsimmuntherapie sind.</p> </div> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-4 mpc-column"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img width="1602" height="1199" src="https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/iStock_000011686797Medium.jpg" class="vc_single_image-img attachment-full" alt="" loading="lazy" srcset="https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/iStock_000011686797Medium.jpg 1602w, https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/iStock_000011686797Medium-300x225.jpg 300w, https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/iStock_000011686797Medium-768x575.jpg 768w, https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/iStock_000011686797Medium-1024x766.jpg 1024w" sizes="(max-width: 1602px) 100vw, 1602px"></div> </figure> </div> </div></div></div></div></div></div><div class="vc_tta-panel" id="1484240334911-615bfd96-bf35" data-vc-content=".vc_tta-panel-body"><div class="vc_tta-panel-heading"><h4 class="vc_tta-panel-title vc_tta-controls-icon-position-left"><a href="#1484240334911-615bfd96-bf35" data-vc-accordion data-vc-container=".vc_tta-container"><span class="vc_tta-title-text">Zelltherapie</span><i class="vc_tta-controls-icon vc_tta-controls-icon-plus"></i></a></h4></div><div class="vc_tta-panel-body"><div class="vc_row wpb_row vc_inner vc_row-fluid vc_column-gap-15 mpc-row"><div class="wpb_column vc_column_container vc_col-sm-8 mpc-column"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element "> <div class="wpb_wrapper"> <p>Zelltherapien gehören zu den erfolgreichsten innovativen Ansätzen in der individualisierten Behandlung von Krebs und zu einem weiterhin wichtigen Forschungsfeld. 2011 kam es zur Zulassung der ersten Tumorvakzine auf der Basis dendritischer Zellen zur Therapie von kastrationsresistentem Prostatakrebs im fortgeschrittenen Stadium durch die amerikanische Zulassungsbehörde FDA. Unabhängige Forscher aus aller Welt haben bereits vielversprechende Resultate beim adoptiven Transfer von tumorspezifischen Lymphozyten erzielt.</p> <p>Wissenschaftler am TRON entwickeln eigene Technologien für die Klonierung und Charakterisierung von antigenspezifischen Zellrezeptoren. Ein Expertenteam am TRON kloniert unter Verwendung einer etablierten Technologieplattform neue T-Zell-Rezeptoren (TZR). TRON führt auch F&E-Projekte in Zusammenarbeit mit anderen Einrichtungen durch. Die gegenwärtige Forschung konzentriert sich vor allem auf Möglichkeiten, den Phänotyp von T-Lymphozyten nach dem Transfer von TZR-Genen zu kontrollieren und zu modifizieren. Unsere Zielsetzung sind bessere therapeutische Ansätze und dafür entwickeln wir genetisch modifizierte Lymphozyten für die Behandlung von schweren Krankheiten.</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-4 mpc-column"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img width="1000" height="750" src="https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/Kachel_immther_Cellular.jpg" class="vc_single_image-img attachment-full" alt="" loading="lazy" srcset="https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/Kachel_immther_Cellular.jpg 1000w, https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/Kachel_immther_Cellular-300x225.jpg 300w, https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/Kachel_immther_Cellular-768x576.jpg 768w" sizes="(max-width: 1000px) 100vw, 1000px"></div> </figure> </div> </div></div></div></div></div></div><div class="vc_tta-panel" id="1484240433002-25c43a54-1e9d" data-vc-content=".vc_tta-panel-body"><div class="vc_tta-panel-heading"><h4 class="vc_tta-panel-title vc_tta-controls-icon-position-left"><a href="#1484240433002-25c43a54-1e9d" data-vc-accordion data-vc-container=".vc_tta-container"><span class="vc_tta-title-text">Kombinationstherapien</span><i class="vc_tta-controls-icon vc_tta-controls-icon-plus"></i></a></h4></div><div class="vc_tta-panel-body"><div class="vc_row wpb_row vc_inner vc_row-fluid vc_column-gap-15 mpc-row"><div class="wpb_column vc_column_container vc_col-sm-8 mpc-column"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element "> <div class="wpb_wrapper"> <p>Wir sind der Auffassung, dass Monotherapien nur der erste Schritt sind, um effektive Anti-Tumor-Effekte mit immuntherapeutischen Ansätzen zu erzielen. Das Potenzial von Immuntherapien kann nur durch die Kombination von Strahlentherapie, Chemotherapie und unterschiedlichen Immuntherapien voll ausgeschöpft werden.</p> <p>Daher untersuchen wir zunächst unterschiedliche Substanzen, ob und wie sie die Mikroumgebung von Tumoren modulieren, sowie ihren Einfluss auf die adaptive und angeborene Immunität. Die ausgewählten Substanzen werden dann mit etablierten Immuntherapeutika kombiniert und in <em>in vivo</em>-Experimenten validiert. Die Kombination von <em>in vitro</em>-Screening-Methoden und der <em>in vivo</em>-Validierung erlaubt es uns, umfassende vorklinische Daten zu generieren, die dann klinisch getestet werden können.</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-4 mpc-column"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img width="4320" height="2868" src="https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/DSC2944.jpg" class="vc_single_image-img attachment-full" alt="" loading="lazy" srcset="https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/DSC2944.jpg 4320w, https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/DSC2944-300x199.jpg 300w, https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/DSC2944-768x510.jpg 768w, https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/DSC2944-1024x680.jpg 1024w" sizes="(max-width: 4320px) 100vw, 4320px"></div> </figure> </div> </div></div></div></div></div></div><div class="vc_tta-panel" id="1484240471918-05f08ace-4e1e" data-vc-content=".vc_tta-panel-body"><div class="vc_tta-panel-heading"><h4 class="vc_tta-panel-title vc_tta-controls-icon-position-left"><a href="#1484240471918-05f08ace-4e1e" data-vc-accordion data-vc-container=".vc_tta-container"><span class="vc_tta-title-text">Nanopartikel</span><i class="vc_tta-controls-icon vc_tta-controls-icon-plus"></i></a></h4></div><div class="vc_tta-panel-body"><div class="vc_row wpb_row vc_inner vc_row-fluid vc_column-gap-15 mpc-row"><div class="wpb_column vc_column_container vc_col-sm-8 mpc-column"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element "> <div class="wpb_wrapper"> <div class="mainContents"> <div class="mainContentsColfull"> <div class="su-column su-column-size-2-3"> <div class="su-column-inner su-clearfix"> <p>Nanopartikel-Wirkstoffträger sind kolloidale Präparationen von Partikeln und Molekülaggregaten in einem Größenbereich von 1 bis ca. 1000 nm. Liposomen zählen zu den heute am besten etablierten Wirkstoffträgern. In den letzten Jahren wurden zahlreiche Nanopartikel-Wirkstoffträger aus der Grundlagenforschung heraus bis in die späte klinische Erprobung und sogar bis hin zur Patientenversorgung weiterentwickelt.</p> <p>Am TRON entwickeln wir lipidbasierte und andere Nanopartikel-Formulierungen als Wirkstoffträger, von kleinen Molekülen bis hin zu hochmolekularen Nukleinsäuren. Wir bieten maßgeschneiderte Formulierungen für die Abgabe der von den Arzneimittel-Entwicklungsabteilungen des TRON hergestellten Substanzen an. Dazu zählen auch Lipoplex-Formulierungen, die sich besonders für die systemische Verabreichung von mRNA eignen.</p> <p>Zudem liefern wir auch Nanopartikel-Formulierungen als Referenzen für Forschungsprojekte; unter anderem fluoreszenz-(NIR) markierte Liposomen mit definierter Beladung und molekularer Zusammensetzung oder auch nach Kundenwunsch für definierte Anwendungen hergestellte Transfektionsreagenzien.</p> </div> </div> </div> </div> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-4 mpc-column"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img width="1920" height="1080" src="https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/liposome3.png" class="vc_single_image-img attachment-full" alt="" loading="lazy" srcset="https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/liposome3.png 1920w, https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/liposome3-300x169.png 300w, https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/liposome3-768x432.png 768w, https://web.archive.org/web/20210320060930im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/01/liposome3-1024x576.png 1024w" sizes="(max-width: 1920px) 100vw, 1920px"></div> </figure> </div> </div></div></div></div></div></div></div></div></div></div></div></div></div><div class="wpb_column vc_column_container vc_col-sm-3 mpc-column"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="vc_grid-container-wrapper vc_clearfix"> <div class="vc_grid-container vc_clearfix wpb_content_element vc_basic_grid" data-initial-loading-animation="fadeIn" 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