CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width, initial-scale=1"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>Roger Markwald - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "profiles/works", 'action': "summary", 'controller_action': 'profiles/works#summary', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="uQ0LgAl+wltpK9qYYGVASb5E8SbzAkNbD3YtBT3YNSsTxU7mVGgmdRdJAO0MBb454FSdDFkmPbnqIELtDyQ1Zg==" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/wow-77f7b87cb1583fc59aa8f94756ebfe913345937eb932042b4077563bebb5fb4b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/social/home-1c712297ae3ac71207193b1bae0ecf1aae125886850f62c9c0139dd867630797.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-b2b823dd904da60a48fd1bfa1defd840610c2ff414d3f39ed3af46277ab8df3b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/text_button-73590134e40cdb49f9abdc8e796cc00dc362693f3f0f6137d6cf9bb78c318ce7.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-10fa40af19d25203774df2d4a03b9b5771b45109c2304968038e88a81d1215c5.css" /> <meta name="author" content="roger markwald" /> <meta name="description" content="Research interests: Cardiovascular Developmental Biology, 3D bioprinting, cell signaling, matricellular proteins Current Position: Distinguished…" /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'works'; var $action_name = "summary"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":15270,"monthly_visitors":"112 million","monthly_visitor_count":112794806,"monthly_visitor_count_in_millions":112,"user_count":277227810,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1732499956000); window.Aedu.timeDifference = new Date().getTime() - 1732499956000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" rel="stylesheet"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-296162c7af6fd81dcdd76f1a94f1fad04fb5f647401337d136fe8b68742170b1.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-8d53a22151f33ab413d88fa1c02f979c3f8706d470fc1bced09852c72a9f3454.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-f8fe82512740391f81c9e8cc48220144024b425b359b08194e316f4de070b9e8.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://independent.academia.edu/RogerMarkwald" /> </head>   <body class='c-profiles/works a-summary logged_out'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://medium.com/@academia">Blog</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <script src="//a.academia-assets.com/assets/webpack_bundles/profile.wjs-bundle-9601d1cc3d68aa07c0a9901d03d3611aec04cc07d2a2039718ebef4ad4d148ca.js" defer="defer"></script><script>Aedu.rankings = { showPaperRankingsLink: false } $viewedUser = Aedu.User.set_viewed( {"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald","photo":"https://0.academia-photos.com/38217099/19173701/19119789/s65_roger.markwald.jpg","has_photo":true,"is_analytics_public":false,"interests":[{"id":162983,"name":"Absorption","url":"https://www.academia.edu/Documents/in/Absorption"},{"id":46278,"name":"Biomedical Ethics","url":"https://www.academia.edu/Documents/in/Biomedical_Ethics"},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure"},{"id":12438,"name":"Plotinus","url":"https://www.academia.edu/Documents/in/Plotinus"},{"id":168056,"name":"Jehovah's Witnesses","url":"https://www.academia.edu/Documents/in/Jehovahs_Witnesses"}]} ); if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = []</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/RogerMarkwald","location":"/RogerMarkwald","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/RogerMarkwald","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-ca210bbb-8073-4d51-b88c-23ce733394a8"></div> <div id="ProfileCheckPaperUpdate-react-component-ca210bbb-8073-4d51-b88c-23ce733394a8"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" alt="Roger Markwald" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/38217099/19173701/19119789/s200_roger.markwald.jpg" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Roger Markwald</h1><div class="affiliations-container fake-truncate js-profile-affiliations"></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Roger" data-follow-user-id="38217099" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="38217099"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">88</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">26</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">24</p></div></a><a href="/RogerMarkwald/mentions"><div class="stat-container"><p class="label">Mentions</p><p class="data">2,330</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="user-bio-container"><div class="profile-bio fake-truncate js-profile-about" style="margin: 0px;">Research interests:  Cardiovascular Developmental Biology,  3D bioprinting,  cell signaling,  matricellular proteins Current Position:  Distinguished University Professor, Department of Regenerative Medicine, Medical University of South Carolina<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="38217099" href="https://www.academia.edu/Documents/in/Absorption"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/RogerMarkwald","location":"/RogerMarkwald","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/RogerMarkwald","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Absorption"]}" data-trace="false" data-dom-id="Pill-react-component-7f6649e0-0c2b-4ad2-82ad-a35cd811e8aa"></div> <div id="Pill-react-component-7f6649e0-0c2b-4ad2-82ad-a35cd811e8aa"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="38217099" href="https://www.academia.edu/Documents/in/Biomedical_Ethics"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Biomedical Ethics"]}" data-trace="false" data-dom-id="Pill-react-component-2e76ce0f-b966-4028-86c2-969d513e8453"></div> <div id="Pill-react-component-2e76ce0f-b966-4028-86c2-969d513e8453"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="38217099" href="https://www.academia.edu/Documents/in/Heart_Failure"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Heart Failure"]}" data-trace="false" data-dom-id="Pill-react-component-a0ce95c1-76d0-4978-bc43-d9f5edd0a6fa"></div> <div id="Pill-react-component-a0ce95c1-76d0-4978-bc43-d9f5edd0a6fa"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="38217099" href="https://www.academia.edu/Documents/in/Plotinus"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Plotinus"]}" data-trace="false" data-dom-id="Pill-react-component-ed4cc687-4550-49ae-b29e-2700ccf37c40"></div> <div id="Pill-react-component-ed4cc687-4550-49ae-b29e-2700ccf37c40"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="38217099" href="https://www.academia.edu/Documents/in/Jehovahs_Witnesses"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Jehovah's Witnesses"]}" data-trace="false" data-dom-id="Pill-react-component-296a2390-bef4-41d0-ab82-d373e8c8cad6"></div> <div id="Pill-react-component-296a2390-bef4-41d0-ab82-d373e8c8cad6"></div> </a></div></div><div class="external-links-container"><ul class="profile-links new-profile js-UserInfo-social"><li><a class="ds2-5-text-link ds2-5-text-link--small" href="https://rogermarkwald.academia.edu/"><span class="ds2-5-text-link__content"><i class="fa fa-laptop"></i></span></a></li><li class="profile-profiles js-social-profiles-container"><i class="fa fa-spin fa-spinner"></i></li></ul></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Roger Markwald</h3></div><div class="js-work-strip profile--work_container" data-work-id="101949852"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/101949852/Viability_of_Bioprinted_Cellular_Constructs_Using_a_Three_Dispenser_Cartesian_Printer"><img alt="Research paper thumbnail of Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer" class="work-thumbnail" src="https://attachments.academia-assets.com/102347670/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/101949852/Viability_of_Bioprinted_Cellular_Constructs_Using_a_Three_Dispenser_Cartesian_Printer">Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer</a></div><div class="wp-workCard_item"><span>Journal of Visualized Experiments</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8f02940292bbdb7ee3aa9b6f20815226" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102347670,"asset_id":101949852,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102347670/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="101949852"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="101949852"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 101949852; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=101949852]").text(description); $(".js-view-count[data-work-id=101949852]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 101949852; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='101949852']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 101949852, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8f02940292bbdb7ee3aa9b6f20815226" } } $('.js-work-strip[data-work-id=101949852]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":101949852,"title":"Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer","translated_title":"","metadata":{"publisher":"MyJove Corporation","publication_name":"Journal of Visualized Experiments"},"translated_abstract":null,"internal_url":"https://www.academia.edu/101949852/Viability_of_Bioprinted_Cellular_Constructs_Using_a_Three_Dispenser_Cartesian_Printer","translated_internal_url":"","created_at":"2023-05-17T19:27:48.942-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":102347670,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102347670/thumbnails/1.jpg","file_name":"jove-materials-53156-viability-bioprinted-cellular-constructs-using-three-dispenser.pdf","download_url":"https://www.academia.edu/attachments/102347670/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Viability_of_Bioprinted_Cellular_Constru.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102347670/jove-materials-53156-viability-bioprinted-cellular-constructs-using-three-dispenser-libre.pdf?1684378955=\u0026response-content-disposition=attachment%3B+filename%3DViability_of_Bioprinted_Cellular_Constru.pdf\u0026Expires=1732499581\u0026Signature=FoEcG-Qbp24X9nTmdZhoQ5W6oKkrnGiRg7T0N4cQces8y0V3mUNSD-oSGAif8jex0jLprd5CPwL0pxbzJ8rgnENgCrXECdimIdTsv2B24DG5~Pvdv4u1kebrzej2tDAE6O4Dj-ru9If76sYLc22OAgmKifqtr4s8wAKKsbeMgcMV98ZfdKcOLsAnoGvxfsB2LRCfIkG-7OWzA2DCV28CkET-RhKbYSdup0O8DNUw0Zy5LEDkx6krrLRWUABdoqHGpXq4iJ0oxnUGfser5W7b7tsIMXT4KqvyJG-l9YtKSo7orkvugZfF8L9f8x639TjFlW3V1o0CvHsoSrTe-wjp0w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Viability_of_Bioprinted_Cellular_Constructs_Using_a_Three_Dispenser_Cartesian_Printer","translated_slug":"","page_count":2,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":102347670,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102347670/thumbnails/1.jpg","file_name":"jove-materials-53156-viability-bioprinted-cellular-constructs-using-three-dispenser.pdf","download_url":"https://www.academia.edu/attachments/102347670/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Viability_of_Bioprinted_Cellular_Constru.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102347670/jove-materials-53156-viability-bioprinted-cellular-constructs-using-three-dispenser-libre.pdf?1684378955=\u0026response-content-disposition=attachment%3B+filename%3DViability_of_Bioprinted_Cellular_Constru.pdf\u0026Expires=1732499581\u0026Signature=FoEcG-Qbp24X9nTmdZhoQ5W6oKkrnGiRg7T0N4cQces8y0V3mUNSD-oSGAif8jex0jLprd5CPwL0pxbzJ8rgnENgCrXECdimIdTsv2B24DG5~Pvdv4u1kebrzej2tDAE6O4Dj-ru9If76sYLc22OAgmKifqtr4s8wAKKsbeMgcMV98ZfdKcOLsAnoGvxfsB2LRCfIkG-7OWzA2DCV28CkET-RhKbYSdup0O8DNUw0Zy5LEDkx6krrLRWUABdoqHGpXq4iJ0oxnUGfser5W7b7tsIMXT4KqvyJG-l9YtKSo7orkvugZfF8L9f8x639TjFlW3V1o0CvHsoSrTe-wjp0w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":422,"name":"Computer Science","url":"https://www.academia.edu/Documents/in/Computer_Science"},{"id":2699,"name":"Tissue Engineering","url":"https://www.academia.edu/Documents/in/Tissue_Engineering"},{"id":5467,"name":"Biomimetics","url":"https://www.academia.edu/Documents/in/Biomimetics"},{"id":6160,"name":"Computer Aided Design","url":"https://www.academia.edu/Documents/in/Computer_Aided_Design"},{"id":22442,"name":"Hydrogels","url":"https://www.academia.edu/Documents/in/Hydrogels"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":29149,"name":"Extracellular Matrix","url":"https://www.academia.edu/Documents/in/Extracellular_Matrix"},{"id":53293,"name":"Software","url":"https://www.academia.edu/Documents/in/Software"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":136801,"name":"Fabrication","url":"https://www.academia.edu/Documents/in/Fabrication"},{"id":387484,"name":"Alginates","url":"https://www.academia.edu/Documents/in/Alginates"},{"id":472784,"name":"Adipocytes","url":"https://www.academia.edu/Documents/in/Adipocytes"},{"id":477968,"name":"Stromal Cells","url":"https://www.academia.edu/Documents/in/Stromal_Cells"},{"id":785710,"name":"Bioprinting","url":"https://www.academia.edu/Documents/in/Bioprinting"},{"id":2049894,"name":"3-D bioprinting","url":"https://www.academia.edu/Documents/in/3-D_bioprinting"},{"id":3873187,"name":"Tissue Scaffolds","url":"https://www.academia.edu/Documents/in/Tissue_Scaffolds"}],"urls":[{"id":31533695,"url":"https://www.jove.com/v/53156/viability-bioprinted-cellular-constructs-using-three-dispenser"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96423325"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96423325/Accepted_by"><img alt="Research paper thumbnail of Accepted by" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96423325/Accepted_by">Accepted by</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">iii To precisely control the position of multiple cell types in a culture for the study of cell-c...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">iii To precisely control the position of multiple cell types in a culture for the study of cell-cell contact interactions, we have developed a laser micropatterning technique. The technique employs the optical forces of a weakly focused laser beam. In the beam’s focal region, the optical force draws microparticles, such as cells, into the center of the beam, propels them along the beam axis, and guides them onto a target surface. Specific patterns are created through computer-controlled micromanipulation of the substrate relative to the laser. In this thesis, we systematically vary the controllable laser parameters, namely, wavelength, intensity, and exposure time of the laser on single cells to clearly establish laser parameters that allow negligible cell damage with significant cellular position control. To accomplish this goal, embryonic day 7 (E7) chick forebrains neurons were cultured with control and test cells selected one hour after seeding to allow attachment, at which time...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96423325"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96423325"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96423325; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96423325]").text(description); $(".js-view-count[data-work-id=96423325]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96423325; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96423325']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96423325, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=96423325]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96423325,"title":"Accepted by","translated_title":"","metadata":{"abstract":"iii To precisely control the position of multiple cell types in a culture for the study of cell-cell contact interactions, we have developed a laser micropatterning technique. The technique employs the optical forces of a weakly focused laser beam. In the beam’s focal region, the optical force draws microparticles, such as cells, into the center of the beam, propels them along the beam axis, and guides them onto a target surface. Specific patterns are created through computer-controlled micromanipulation of the substrate relative to the laser. In this thesis, we systematically vary the controllable laser parameters, namely, wavelength, intensity, and exposure time of the laser on single cells to clearly establish laser parameters that allow negligible cell damage with significant cellular position control. To accomplish this goal, embryonic day 7 (E7) chick forebrains neurons were cultured with control and test cells selected one hour after seeding to allow attachment, at which time...","publication_date":{"day":null,"month":null,"year":2007,"errors":{}}},"translated_abstract":"iii To precisely control the position of multiple cell types in a culture for the study of cell-cell contact interactions, we have developed a laser micropatterning technique. The technique employs the optical forces of a weakly focused laser beam. In the beam’s focal region, the optical force draws microparticles, such as cells, into the center of the beam, propels them along the beam axis, and guides them onto a target surface. Specific patterns are created through computer-controlled micromanipulation of the substrate relative to the laser. In this thesis, we systematically vary the controllable laser parameters, namely, wavelength, intensity, and exposure time of the laser on single cells to clearly establish laser parameters that allow negligible cell damage with significant cellular position control. To accomplish this goal, embryonic day 7 (E7) chick forebrains neurons were cultured with control and test cells selected one hour after seeding to allow attachment, at which time...","internal_url":"https://www.academia.edu/96423325/Accepted_by","translated_internal_url":"","created_at":"2023-02-06T11:00:17.407-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Accepted_by","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[],"research_interests":[],"urls":[{"id":28745539,"url":"http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1031.7751\u0026rep=rep1\u0026type=pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="91173970"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/91173970/FOLFOX_Therapy_Induces_Feedback_Upregulation_of_CD44v6_through_YB_1_to_Maintain_Stemness_in_Colon_Initiating_Cells"><img alt="Research paper thumbnail of FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating Cells" class="work-thumbnail" src="https://attachments.academia-assets.com/94535862/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/91173970/FOLFOX_Therapy_Induces_Feedback_Upregulation_of_CD44v6_through_YB_1_to_Maintain_Stemness_in_Colon_Initiating_Cells">FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating Cells</a></div><div class="wp-workCard_item"><span>International Journal of Molecular Sciences</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cancer initiating cells (CICs) drive tumor formation and drug-resistance, but how they develop dr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cancer initiating cells (CICs) drive tumor formation and drug-resistance, but how they develop drug-resistance characteristics is not well understood. In this study, we demonstrate that chemotherapeutic agent FOLFOX, commonly used for drug-resistant/metastatic colorectal cancer (CRC) treatment, induces overexpression of CD44v6, MDR1, and oncogenic transcription/translation factor Y-box-binding protein-1 (YB-1). Our study revealed that CD44v6, a receptor for hyaluronan, increased the YB-1 expression through PGE2/EP1-mTOR pathway. Deleting CD44v6, and YB-1 by the CRISPR/Cas9 system attenuates the in vitro and in vivo tumor growth of CICs from FOLFOX resistant cells. The results of DNA:CD44v6 immunoprecipitated complexes by ChIP (chromatin-immunoprecipitation) assay showed that CD44v6 maintained the stemness traits by promoting several antiapoptotic and stemness genes, including cyclin-D1,BCL2,FZD1,GINS-1, and MMP9. Further, computer-based analysis of the clones obtained from the DNA:C...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="012f15f427746aeee06fe4c67b3347f4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94535862,"asset_id":91173970,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94535862/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="91173970"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="91173970"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 91173970; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=91173970]").text(description); $(".js-view-count[data-work-id=91173970]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 91173970; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='91173970']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 91173970, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "012f15f427746aeee06fe4c67b3347f4" } } $('.js-work-strip[data-work-id=91173970]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":91173970,"title":"FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating Cells","translated_title":"","metadata":{"abstract":"Cancer initiating cells (CICs) drive tumor formation and drug-resistance, but how they develop drug-resistance characteristics is not well understood. In this study, we demonstrate that chemotherapeutic agent FOLFOX, commonly used for drug-resistant/metastatic colorectal cancer (CRC) treatment, induces overexpression of CD44v6, MDR1, and oncogenic transcription/translation factor Y-box-binding protein-1 (YB-1). Our study revealed that CD44v6, a receptor for hyaluronan, increased the YB-1 expression through PGE2/EP1-mTOR pathway. Deleting CD44v6, and YB-1 by the CRISPR/Cas9 system attenuates the in vitro and in vivo tumor growth of CICs from FOLFOX resistant cells. The results of DNA:CD44v6 immunoprecipitated complexes by ChIP (chromatin-immunoprecipitation) assay showed that CD44v6 maintained the stemness traits by promoting several antiapoptotic and stemness genes, including cyclin-D1,BCL2,FZD1,GINS-1, and MMP9. Further, computer-based analysis of the clones obtained from the DNA:C...","publisher":"MDPI AG","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"International Journal of Molecular Sciences"},"translated_abstract":"Cancer initiating cells (CICs) drive tumor formation and drug-resistance, but how they develop drug-resistance characteristics is not well understood. In this study, we demonstrate that chemotherapeutic agent FOLFOX, commonly used for drug-resistant/metastatic colorectal cancer (CRC) treatment, induces overexpression of CD44v6, MDR1, and oncogenic transcription/translation factor Y-box-binding protein-1 (YB-1). Our study revealed that CD44v6, a receptor for hyaluronan, increased the YB-1 expression through PGE2/EP1-mTOR pathway. Deleting CD44v6, and YB-1 by the CRISPR/Cas9 system attenuates the in vitro and in vivo tumor growth of CICs from FOLFOX resistant cells. The results of DNA:CD44v6 immunoprecipitated complexes by ChIP (chromatin-immunoprecipitation) assay showed that CD44v6 maintained the stemness traits by promoting several antiapoptotic and stemness genes, including cyclin-D1,BCL2,FZD1,GINS-1, and MMP9. Further, computer-based analysis of the clones obtained from the DNA:C...","internal_url":"https://www.academia.edu/91173970/FOLFOX_Therapy_Induces_Feedback_Upregulation_of_CD44v6_through_YB_1_to_Maintain_Stemness_in_Colon_Initiating_Cells","translated_internal_url":"","created_at":"2022-11-19T22:04:22.539-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94535862,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94535862/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/94535862/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"FOLFOX_Therapy_Induces_Feedback_Upregula.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94535862/pdf-libre.pdf?1668928323=\u0026response-content-disposition=attachment%3B+filename%3DFOLFOX_Therapy_Induces_Feedback_Upregula.pdf\u0026Expires=1732499582\u0026Signature=ClPGq43eYMeg6lfah1JjLbKt8xCBXEMfqeKIjB3y9J7oN3t3dLuK3S1XkAocWN~IxVzgFdgBxBSlqknutJZMq9LG3NbTeU~ANTBepCBonQNnfHtEFoHve6UVZQQWFQt176Cp7Pnq9J2aPGx5ZxVN4iLcbLIcOaUtnK8~QzfuA4W1cWVHqd74eG19snMWSgIXF1npXP~NFUYUn2bsrNJvkK~DsNA75F5rrdReGTx8B0MQnZpBIBAth6xtwj8Q6omjuaJ9pTDwBILB21Fk-pncZvoPCM8bGGgF0lTC69XP0gwW9yXpx8HU0SdCi8Mv86kMOXv9E448UmeLdAzhQFAvTw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"FOLFOX_Therapy_Induces_Feedback_Upregulation_of_CD44v6_through_YB_1_to_Maintain_Stemness_in_Colon_Initiating_Cells","translated_slug":"","page_count":37,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":94535862,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94535862/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/94535862/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"FOLFOX_Therapy_Induces_Feedback_Upregula.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94535862/pdf-libre.pdf?1668928323=\u0026response-content-disposition=attachment%3B+filename%3DFOLFOX_Therapy_Induces_Feedback_Upregula.pdf\u0026Expires=1732499582\u0026Signature=ClPGq43eYMeg6lfah1JjLbKt8xCBXEMfqeKIjB3y9J7oN3t3dLuK3S1XkAocWN~IxVzgFdgBxBSlqknutJZMq9LG3NbTeU~ANTBepCBonQNnfHtEFoHve6UVZQQWFQt176Cp7Pnq9J2aPGx5ZxVN4iLcbLIcOaUtnK8~QzfuA4W1cWVHqd74eG19snMWSgIXF1npXP~NFUYUn2bsrNJvkK~DsNA75F5rrdReGTx8B0MQnZpBIBAth6xtwj8Q6omjuaJ9pTDwBILB21Fk-pncZvoPCM8bGGgF0lTC69XP0gwW9yXpx8HU0SdCi8Mv86kMOXv9E448UmeLdAzhQFAvTw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":94535863,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94535863/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/94535863/download_file","bulk_download_file_name":"FOLFOX_Therapy_Induces_Feedback_Upregula.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94535863/pdf-libre.pdf?1668928335=\u0026response-content-disposition=attachment%3B+filename%3DFOLFOX_Therapy_Induces_Feedback_Upregula.pdf\u0026Expires=1732499582\u0026Signature=H8v61Y50vWevCVPpbV8F2NDsHM1kl8f8vBCJeCMsV5KCf5UFTgmxl8IRx2vYXE4cYVn0OYYu-z2RltdZ-wheO46MMkoBWZlRdeE5SGgMdd17mSWHqfuUXv5iLArAYdLyLfyInKRRdFL8Z0fa3GJzOKhNL2SJ~V8GVxbec2xfsjYRbZAreAxeYInwMeA6Ic7uhPsurLr~kO8fWJxZHdrqVWFjn0cXxppriwXVhpyt0npMA2biXFG~EsZPaOB~kMIEpUJ-n-NDhwPs8Mwzb9BJY6RQCXLSja0yZb0zoc3sSqpB7yozEjxO7aPmHdSAe4dma53MfNS1oY7SaDtaBP~Dpg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":37292,"name":"Colorectal cancer","url":"https://www.academia.edu/Documents/in/Colorectal_cancer"},{"id":216943,"name":"CD","url":"https://www.academia.edu/Documents/in/CD"},{"id":275658,"name":"Cancer Stem Cell","url":"https://www.academia.edu/Documents/in/Cancer_Stem_Cell"},{"id":276821,"name":"Molecular sciences","url":"https://www.academia.edu/Documents/in/Molecular_sciences"},{"id":440820,"name":"Chromatin Immunoprecipitation","url":"https://www.academia.edu/Documents/in/Chromatin_Immunoprecipitation"}],"urls":[{"id":26174390,"url":"https://www.mdpi.com/1422-0067/22/2/753/pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528495"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528495/Scalable_robotic_biofabrication_of_tissue_spheroids"><img alt="Research paper thumbnail of Scalable robotic biofabrication of tissue spheroids" class="work-thumbnail" src="https://attachments.academia-assets.com/90200533/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528495/Scalable_robotic_biofabrication_of_tissue_spheroids">Scalable robotic biofabrication of tissue spheroids</a></div><div class="wp-workCard_item"><span>Biofabrication</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bcf32a167ecb1718091e41c0be63925e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200533,"asset_id":85528495,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200533/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528495"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528495"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528495; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528495]").text(description); $(".js-view-count[data-work-id=85528495]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528495; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528495']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528495, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "bcf32a167ecb1718091e41c0be63925e" } } $('.js-work-strip[data-work-id=85528495]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528495,"title":"Scalable robotic biofabrication of tissue spheroids","translated_title":"","metadata":{"publisher":"IOP Publishing","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Biofabrication"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528495/Scalable_robotic_biofabrication_of_tissue_spheroids","translated_internal_url":"","created_at":"2022-08-24T07:48:08.555-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200533,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200533/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200533/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Scalable_robotic_biofabrication_of_tissu.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200533/ptpmcrender-libre.pdf?1661355231=\u0026response-content-disposition=attachment%3B+filename%3DScalable_robotic_biofabrication_of_tissu.pdf\u0026Expires=1732499582\u0026Signature=b65R4ULB-2jcwttwW~iMHzHdODCMcmwJRibUGdRqcFgmX8khBWgGgBjyxks5eErWpFfoSAeC-n40MR3u~eczI3RdOnSeKX5mebR5uB8Iene4gMhHo1NlCV5oweE~O0Crwfo4vMnJBCjLHCQMMo5qbK9xPbJTa9dl8BZtnBWUi87Zla28L1MxwbiN2MpdGxOKIyriBLp5NUKgXSvIbf04o6Sg58RRfpO~sxvkF3Lte8QY7fTe5PjFRl7hSflrZCh-JILsStpLPG4QdrA590hfim0ktZF9sLFUuixXKX~eWRlaUqmPnQpPwnV6W2qN704SkIzbOqKaIRgvLeebi-N8JA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Scalable_robotic_biofabrication_of_tissue_spheroids","translated_slug":"","page_count":16,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200533,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200533/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200533/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Scalable_robotic_biofabrication_of_tissu.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200533/ptpmcrender-libre.pdf?1661355231=\u0026response-content-disposition=attachment%3B+filename%3DScalable_robotic_biofabrication_of_tissu.pdf\u0026Expires=1732499582\u0026Signature=b65R4ULB-2jcwttwW~iMHzHdODCMcmwJRibUGdRqcFgmX8khBWgGgBjyxks5eErWpFfoSAeC-n40MR3u~eczI3RdOnSeKX5mebR5uB8Iene4gMhHo1NlCV5oweE~O0Crwfo4vMnJBCjLHCQMMo5qbK9xPbJTa9dl8BZtnBWUi87Zla28L1MxwbiN2MpdGxOKIyriBLp5NUKgXSvIbf04o6Sg58RRfpO~sxvkF3Lte8QY7fTe5PjFRl7hSflrZCh-JILsStpLPG4QdrA590hfim0ktZF9sLFUuixXKX~eWRlaUqmPnQpPwnV6W2qN704SkIzbOqKaIRgvLeebi-N8JA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":511,"name":"Materials Science","url":"https://www.academia.edu/Documents/in/Materials_Science"},{"id":2699,"name":"Tissue Engineering","url":"https://www.academia.edu/Documents/in/Tissue_Engineering"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52489,"name":"Adipose tissue","url":"https://www.academia.edu/Documents/in/Adipose_tissue"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":66379,"name":"Automation","url":"https://www.academia.edu/Documents/in/Automation"},{"id":216119,"name":"Biofabrication","url":"https://www.academia.edu/Documents/in/Biofabrication"},{"id":401634,"name":"Additive Manufaturing","url":"https://www.academia.edu/Documents/in/Additive_Manufaturing"},{"id":1877951,"name":"Cell Size","url":"https://www.academia.edu/Documents/in/Cell_Size"},{"id":4121555,"name":"Cell culture techniques","url":"https://www.academia.edu/Documents/in/Cell_culture_techniques"}],"urls":[{"id":23312394,"url":"https://iopscience.iop.org/article/10.1088/1758-5082/3/2/025002/pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528494"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528494/Tissue_engineering_of_heart_valve_leaflet_by_self_assembly_of_tissue_spheroids_biofabricated_from_human_fat_tissue_derived_stem_cells"><img alt="Research paper thumbnail of Tissue engineering of heart valve leaflet by self-assembly of tissue spheroids biofabricated from human fat tissue derived stem cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528494/Tissue_engineering_of_heart_valve_leaflet_by_self_assembly_of_tissue_spheroids_biofabricated_from_human_fat_tissue_derived_stem_cells">Tissue engineering of heart valve leaflet by self-assembly of tissue spheroids biofabricated from human fat tissue derived stem cells</a></div><div class="wp-workCard_item"><span>IFMBE Proceedings</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Bioengineering of living heart valve substitute suitable for implantation into pediatric patients...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bioengineering of living heart valve substitute suitable for implantation into pediatric patients with heart valve diseases is an unsolved challenge in cardiovascular tissue engineering. In order to identify desirable material properties of such construct, the biomechanical, histological, histochemical and biochemical properties of fetal, perinatal and adult porcine heart valve leaflets have been systematically investigated. It have been shown that increasing</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528494"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528494"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528494; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528494]").text(description); $(".js-view-count[data-work-id=85528494]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528494; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528494']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528494, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85528494]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528494,"title":"Tissue engineering of heart valve leaflet by self-assembly of tissue spheroids biofabricated from human fat tissue derived stem cells","translated_title":"","metadata":{"abstract":"Bioengineering of living heart valve substitute suitable for implantation into pediatric patients with heart valve diseases is an unsolved challenge in cardiovascular tissue engineering. In order to identify desirable material properties of such construct, the biomechanical, histological, histochemical and biochemical properties of fetal, perinatal and adult porcine heart valve leaflets have been systematically investigated. It have been shown that increasing","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"IFMBE Proceedings"},"translated_abstract":"Bioengineering of living heart valve substitute suitable for implantation into pediatric patients with heart valve diseases is an unsolved challenge in cardiovascular tissue engineering. In order to identify desirable material properties of such construct, the biomechanical, histological, histochemical and biochemical properties of fetal, perinatal and adult porcine heart valve leaflets have been systematically investigated. It have been shown that increasing","internal_url":"https://www.academia.edu/85528494/Tissue_engineering_of_heart_valve_leaflet_by_self_assembly_of_tissue_spheroids_biofabricated_from_human_fat_tissue_derived_stem_cells","translated_internal_url":"","created_at":"2022-08-24T07:48:08.408-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Tissue_engineering_of_heart_valve_leaflet_by_self_assembly_of_tissue_spheroids_biofabricated_from_human_fat_tissue_derived_stem_cells","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":2699,"name":"Tissue Engineering","url":"https://www.academia.edu/Documents/in/Tissue_Engineering"},{"id":3642,"name":"Stem Cells","url":"https://www.academia.edu/Documents/in/Stem_Cells"},{"id":11073,"name":"Self Assembly","url":"https://www.academia.edu/Documents/in/Self_Assembly"},{"id":23163,"name":"Stem Cell","url":"https://www.academia.edu/Documents/in/Stem_Cell"},{"id":52489,"name":"Adipose tissue","url":"https://www.academia.edu/Documents/in/Adipose_tissue"},{"id":1001094,"name":"Material Properties","url":"https://www.academia.edu/Documents/in/Material_Properties"},{"id":1311840,"name":"Heart Valve","url":"https://www.academia.edu/Documents/in/Heart_Valve"},{"id":2724508,"name":"Mechanical Property","url":"https://www.academia.edu/Documents/in/Mechanical_Property"},{"id":3275513,"name":"Heart valve disease","url":"https://www.academia.edu/Documents/in/Heart_valve_disease"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528493"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528493/Engineering_alginate_as_bioink_for_bioprinting"><img alt="Research paper thumbnail of Engineering alginate as bioink for bioprinting" class="work-thumbnail" src="https://attachments.academia-assets.com/90200537/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528493/Engineering_alginate_as_bioink_for_bioprinting">Engineering alginate as bioink for bioprinting</a></div><div class="wp-workCard_item"><span>Acta biomaterialia</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Recent advances in three-dimensional (3-D) printing offer an excellent opportunity to address cri...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Recent advances in three-dimensional (3-D) printing offer an excellent opportunity to address critical challenges faced by current tissue engineering approaches. Alginate hydrogels have been used extensively as bioinks for 3-D bioprinting. However, most previous research has focused on native alginates with limited degradation. The application of oxidized alginates with controlled degradation in bioprinting has not been explored. Here, a collection of 30 different alginate hydrogels with varied oxidation percentages and concentrations was prepared to develop a bioink platform that can be applied to a multitude of tissue engineering applications. The authors systematically investigated the effects of two key material properties (i.e. viscosity and density) of alginate solutions on their printabilities to identify a suitable range of material properties of alginates to be applied to bioprinting. Further, four alginate solutions with varied biodegradability were printed with human adip...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="96dfe6ca3357790ae89a5e07a5afe644" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200537,"asset_id":85528493,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200537/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528493"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528493"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528493; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528493]").text(description); $(".js-view-count[data-work-id=85528493]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528493; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528493']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528493, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "96dfe6ca3357790ae89a5e07a5afe644" } } $('.js-work-strip[data-work-id=85528493]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528493,"title":"Engineering alginate as bioink for bioprinting","translated_title":"","metadata":{"abstract":"Recent advances in three-dimensional (3-D) printing offer an excellent opportunity to address critical challenges faced by current tissue engineering approaches. Alginate hydrogels have been used extensively as bioinks for 3-D bioprinting. However, most previous research has focused on native alginates with limited degradation. The application of oxidized alginates with controlled degradation in bioprinting has not been explored. Here, a collection of 30 different alginate hydrogels with varied oxidation percentages and concentrations was prepared to develop a bioink platform that can be applied to a multitude of tissue engineering applications. The authors systematically investigated the effects of two key material properties (i.e. viscosity and density) of alginate solutions on their printabilities to identify a suitable range of material properties of alginates to be applied to bioprinting. Further, four alginate solutions with varied biodegradability were printed with human adip...","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Acta biomaterialia"},"translated_abstract":"Recent advances in three-dimensional (3-D) printing offer an excellent opportunity to address critical challenges faced by current tissue engineering approaches. Alginate hydrogels have been used extensively as bioinks for 3-D bioprinting. However, most previous research has focused on native alginates with limited degradation. The application of oxidized alginates with controlled degradation in bioprinting has not been explored. Here, a collection of 30 different alginate hydrogels with varied oxidation percentages and concentrations was prepared to develop a bioink platform that can be applied to a multitude of tissue engineering applications. The authors systematically investigated the effects of two key material properties (i.e. viscosity and density) of alginate solutions on their printabilities to identify a suitable range of material properties of alginates to be applied to bioprinting. Further, four alginate solutions with varied biodegradability were printed with human adip...","internal_url":"https://www.academia.edu/85528493/Engineering_alginate_as_bioink_for_bioprinting","translated_internal_url":"","created_at":"2022-08-24T07:48:08.290-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200537,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200537/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200537/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Engineering_alginate_as_bioink_for_biopr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200537/ptpmcrender-libre.pdf?1661355226=\u0026response-content-disposition=attachment%3B+filename%3DEngineering_alginate_as_bioink_for_biopr.pdf\u0026Expires=1732499582\u0026Signature=A7tilo5U9npIVBjuHelGv0kfh2exVcnXkTrNBVUgWEgEI~rjl3BxE3Jhk9T8fiU4m3DtmBAIU5WNYFLq1TOZCmAwyLCkva4ZxPoC8ferql~8cOh5~sKbt9HOQahUAvgmWouppujivSlVGrfWNbCSikHx3ED7H4oS5CCjsytIYcv43aUdS2dsDpr8m5k5-yw-CxKP9GB9SzByWLl5nfLNyN9E9lZyTDBIvpJARLf5e6wFG-p0OxtPQ0GGusl3J-3mcDPqioXbzlnlTCvHBWcqCf6igBCRxunQ7JREEJZLP83Rz1B7pypwFBg~zYMER83Da66UWic4CsRvEaTi80TVeg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Engineering_alginate_as_bioink_for_bioprinting","translated_slug":"","page_count":21,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200537,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200537/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200537/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Engineering_alginate_as_bioink_for_biopr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200537/ptpmcrender-libre.pdf?1661355226=\u0026response-content-disposition=attachment%3B+filename%3DEngineering_alginate_as_bioink_for_biopr.pdf\u0026Expires=1732499582\u0026Signature=A7tilo5U9npIVBjuHelGv0kfh2exVcnXkTrNBVUgWEgEI~rjl3BxE3Jhk9T8fiU4m3DtmBAIU5WNYFLq1TOZCmAwyLCkva4ZxPoC8ferql~8cOh5~sKbt9HOQahUAvgmWouppujivSlVGrfWNbCSikHx3ED7H4oS5CCjsytIYcv43aUdS2dsDpr8m5k5-yw-CxKP9GB9SzByWLl5nfLNyN9E9lZyTDBIvpJARLf5e6wFG-p0OxtPQ0GGusl3J-3mcDPqioXbzlnlTCvHBWcqCf6igBCRxunQ7JREEJZLP83Rz1B7pypwFBg~zYMER83Da66UWic4CsRvEaTi80TVeg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":511,"name":"Materials Science","url":"https://www.academia.edu/Documents/in/Materials_Science"},{"id":2699,"name":"Tissue Engineering","url":"https://www.academia.edu/Documents/in/Tissue_Engineering"},{"id":3642,"name":"Stem Cells","url":"https://www.academia.edu/Documents/in/Stem_Cells"},{"id":22442,"name":"Hydrogels","url":"https://www.academia.edu/Documents/in/Hydrogels"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":52489,"name":"Adipose tissue","url":"https://www.academia.edu/Documents/in/Adipose_tissue"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":216119,"name":"Biofabrication","url":"https://www.academia.edu/Documents/in/Biofabrication"},{"id":224124,"name":"Ink","url":"https://www.academia.edu/Documents/in/Ink"},{"id":387484,"name":"Alginates","url":"https://www.academia.edu/Documents/in/Alginates"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation"},{"id":892969,"name":"Materials Testing","url":"https://www.academia.edu/Documents/in/Materials_Testing"},{"id":1003917,"name":"Three dimensional Printing (3DP)","url":"https://www.academia.edu/Documents/in/Three_dimensional_Printing_3DP_"},{"id":2049894,"name":"3-D bioprinting","url":"https://www.academia.edu/Documents/in/3-D_bioprinting"},{"id":2285371,"name":"D-glucuronic acid","url":"https://www.academia.edu/Documents/in/D-glucuronic_acid"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528492"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528492/Tissue_spheroid_fusion_based_in_vitro_screening_assays_for_analysis_of_tissue_maturation"><img alt="Research paper thumbnail of Tissue spheroid fusion-based in vitro screening assays for analysis of tissue maturation" class="work-thumbnail" src="https://attachments.academia-assets.com/90200534/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528492/Tissue_spheroid_fusion_based_in_vitro_screening_assays_for_analysis_of_tissue_maturation">Tissue spheroid fusion-based in vitro screening assays for analysis of tissue maturation</a></div><div class="wp-workCard_item"><span>Journal of Tissue Engineering and Regenerative Medicine</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a57052fab0d21a1fe07898ef32534f88" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200534,"asset_id":85528492,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200534/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528492"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528492"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528492; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528492]").text(description); $(".js-view-count[data-work-id=85528492]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528492; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528492']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528492, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a57052fab0d21a1fe07898ef32534f88" } } $('.js-work-strip[data-work-id=85528492]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528492,"title":"Tissue spheroid fusion-based in vitro screening assays for analysis of tissue maturation","translated_title":"","metadata":{"publisher":"Wiley","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Journal of Tissue Engineering and Regenerative Medicine"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528492/Tissue_spheroid_fusion_based_in_vitro_screening_assays_for_analysis_of_tissue_maturation","translated_internal_url":"","created_at":"2022-08-24T07:48:08.141-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200534,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200534/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200534/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Tissue_spheroid_fusion_based_in_vitro_sc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200534/ptpmcrender-libre.pdf?1661355227=\u0026response-content-disposition=attachment%3B+filename%3DTissue_spheroid_fusion_based_in_vitro_sc.pdf\u0026Expires=1732499582\u0026Signature=fXIoHxdLAYyySDXB8cja3JrUvYoCj0Zy43Br3KB6O6i4SSym5h5LrnUxTWNEtWJ3Hg~rIT4DobXFaIvuIIUWtJgTAdDP4QzKFJZ2Ay6Wia33T2dvbmd5okScrZyCGhTNNF-2HMu5xwBTOW9s0gcoyrG-aVJtEBb3llNGZqhAfHVawdkxeM~YG577WLBih9bTrv0KCjRDK09iLPOR6yRO0iOwiq21ixZXoe6mrMMlG3qiRTZyvkd4uX~JxpdvAVY7r5lStkk0s275EPfc-IWyWJR5vevPHXJzrou3hPfijDtNhV6WNb-KTEalAKLEM~RMAmp41f7wUslPNkb1gQSYpg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Tissue_spheroid_fusion_based_in_vitro_screening_assays_for_analysis_of_tissue_maturation","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200534,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200534/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200534/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Tissue_spheroid_fusion_based_in_vitro_sc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200534/ptpmcrender-libre.pdf?1661355227=\u0026response-content-disposition=attachment%3B+filename%3DTissue_spheroid_fusion_based_in_vitro_sc.pdf\u0026Expires=1732499582\u0026Signature=fXIoHxdLAYyySDXB8cja3JrUvYoCj0Zy43Br3KB6O6i4SSym5h5LrnUxTWNEtWJ3Hg~rIT4DobXFaIvuIIUWtJgTAdDP4QzKFJZ2Ay6Wia33T2dvbmd5okScrZyCGhTNNF-2HMu5xwBTOW9s0gcoyrG-aVJtEBb3llNGZqhAfHVawdkxeM~YG577WLBih9bTrv0KCjRDK09iLPOR6yRO0iOwiq21ixZXoe6mrMMlG3qiRTZyvkd4uX~JxpdvAVY7r5lStkk0s275EPfc-IWyWJR5vevPHXJzrou3hPfijDtNhV6WNb-KTEalAKLEM~RMAmp41f7wUslPNkb1gQSYpg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering"},{"id":2699,"name":"Tissue Engineering","url":"https://www.academia.edu/Documents/in/Tissue_Engineering"},{"id":18529,"name":"Fluorescent Dyes and Reagents","url":"https://www.academia.edu/Documents/in/Fluorescent_Dyes_and_Reagents"},{"id":59370,"name":"In Vitro","url":"https://www.academia.edu/Documents/in/In_Vitro"},{"id":73614,"name":"Cell fusion","url":"https://www.academia.edu/Documents/in/Cell_fusion"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology"},{"id":199905,"name":"Tissue engineering and regenerative medicine","url":"https://www.academia.edu/Documents/in/Tissue_engineering_and_regenerative_medicine"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":459613,"name":"Dermis","url":"https://www.academia.edu/Documents/in/Dermis"},{"id":954995,"name":"Human Fibroblasts","url":"https://www.academia.edu/Documents/in/Human_Fibroblasts"},{"id":1824499,"name":"Cell Adhesion Molecules","url":"https://www.academia.edu/Documents/in/Cell_Adhesion_Molecules"},{"id":2533047,"name":"fibroblasts","url":"https://www.academia.edu/Documents/in/fibroblasts"},{"id":3276666,"name":"fluorescent dyes","url":"https://www.academia.edu/Documents/in/fluorescent_dyes"}],"urls":[{"id":23312393,"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fterm.291"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528491"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528491/Inhibition_of_Cardiac_Fibrosis_Mediated_by_Non_Myocyte_Proliferation_in_Hypertrophic_Cardiomyopathy"><img alt="Research paper thumbnail of Inhibition of Cardiac Fibrosis Mediated by Non-Myocyte Proliferation in Hypertrophic Cardiomyopathy" class="work-thumbnail" src="https://attachments.academia-assets.com/90200551/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528491/Inhibition_of_Cardiac_Fibrosis_Mediated_by_Non_Myocyte_Proliferation_in_Hypertrophic_Cardiomyopathy">Inhibition of Cardiac Fibrosis Mediated by Non-Myocyte Proliferation in Hypertrophic Cardiomyopathy</a></div><div class="wp-workCard_item"><span>Journal of the American College of Cardiology</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cccd8678b890d39efcd880b3cd969be4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200551,"asset_id":85528491,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200551/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528491"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528491"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528491; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528491]").text(description); $(".js-view-count[data-work-id=85528491]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528491; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528491']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528491, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cccd8678b890d39efcd880b3cd969be4" } } $('.js-work-strip[data-work-id=85528491]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528491,"title":"Inhibition of Cardiac Fibrosis Mediated by Non-Myocyte Proliferation in Hypertrophic Cardiomyopathy","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Journal of the American College of Cardiology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528491/Inhibition_of_Cardiac_Fibrosis_Mediated_by_Non_Myocyte_Proliferation_in_Hypertrophic_Cardiomyopathy","translated_internal_url":"","created_at":"2022-08-24T07:48:08.005-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200551,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200551/thumbnails/1.jpg","file_name":"81163654.pdf","download_url":"https://www.academia.edu/attachments/90200551/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Inhibition_of_Cardiac_Fibrosis_Mediated.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200551/81163654-libre.pdf?1661355225=\u0026response-content-disposition=attachment%3B+filename%3DInhibition_of_Cardiac_Fibrosis_Mediated.pdf\u0026Expires=1732499582\u0026Signature=Sq5iU4HtO6nEmC37ZXvyQUkRlgA8pCbIEblv1jzlcT3HoHQcBBqSoE1rByLnJTJUdbr9lzJt0k~2a9zJ-gMKztneXGCdyqKaIxUil5vmbLc9EDVxWIYQYYm6XuP2EHkn2hmx-gL7Mnf0COUejDuwtMgFG2NG-WX-IilNz885yO0Kj6h-LPvIN84Eo5C99Tj3svmYDANi5VeAx3si2ZtpBgH1uhoBn347AUf0sPFLXBk04A8OeZbqJkksVeeQGkHFz3Zyv5hX3-HTJyzHYP~F~uzZQe6k49UXmDAeEzHwH-hvhyopECxl5wh9MlUlPnTBwu0bb03iE9hgBzS3CF-WOg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Inhibition_of_Cardiac_Fibrosis_Mediated_by_Non_Myocyte_Proliferation_in_Hypertrophic_Cardiomyopathy","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200551,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200551/thumbnails/1.jpg","file_name":"81163654.pdf","download_url":"https://www.academia.edu/attachments/90200551/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Inhibition_of_Cardiac_Fibrosis_Mediated.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200551/81163654-libre.pdf?1661355225=\u0026response-content-disposition=attachment%3B+filename%3DInhibition_of_Cardiac_Fibrosis_Mediated.pdf\u0026Expires=1732499582\u0026Signature=Sq5iU4HtO6nEmC37ZXvyQUkRlgA8pCbIEblv1jzlcT3HoHQcBBqSoE1rByLnJTJUdbr9lzJt0k~2a9zJ-gMKztneXGCdyqKaIxUil5vmbLc9EDVxWIYQYYm6XuP2EHkn2hmx-gL7Mnf0COUejDuwtMgFG2NG-WX-IilNz885yO0Kj6h-LPvIN84Eo5C99Tj3svmYDANi5VeAx3si2ZtpBgH1uhoBn347AUf0sPFLXBk04A8OeZbqJkksVeeQGkHFz3Zyv5hX3-HTJyzHYP~F~uzZQe6k49UXmDAeEzHwH-hvhyopECxl5wh9MlUlPnTBwu0bb03iE9hgBzS3CF-WOg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1"},{"id":916228,"name":"Hypertrophic Cardiomyopathy","url":"https://www.academia.edu/Documents/in/Hypertrophic_Cardiomyopathy"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528490"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528490/Recruitment_of_bone_marrow_derived_valve_interstitial_cells_is_a_normal_homeostatic_process"><img alt="Research paper thumbnail of Recruitment of bone marrow-derived valve interstitial cells is a normal homeostatic process" class="work-thumbnail" src="https://attachments.academia-assets.com/90200599/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528490/Recruitment_of_bone_marrow_derived_valve_interstitial_cells_is_a_normal_homeostatic_process">Recruitment of bone marrow-derived valve interstitial cells is a normal homeostatic process</a></div><div class="wp-workCard_item"><span>Journal of Molecular and Cellular Cardiology</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="683cc8cc4bbf17efc09201dc08d7ef15" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200599,"asset_id":85528490,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200599/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528490"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528490"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528490; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528490]").text(description); $(".js-view-count[data-work-id=85528490]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528490; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528490']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528490, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "683cc8cc4bbf17efc09201dc08d7ef15" } } $('.js-work-strip[data-work-id=85528490]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528490,"title":"Recruitment of bone marrow-derived valve interstitial cells is a normal homeostatic process","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Journal of Molecular and Cellular Cardiology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528490/Recruitment_of_bone_marrow_derived_valve_interstitial_cells_is_a_normal_homeostatic_process","translated_internal_url":"","created_at":"2022-08-24T07:48:07.894-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200599,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200599/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200599/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Recruitment_of_bone_marrow_derived_valve.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200599/ptpmcrender-libre.pdf?1661355226=\u0026response-content-disposition=attachment%3B+filename%3DRecruitment_of_bone_marrow_derived_valve.pdf\u0026Expires=1732499582\u0026Signature=adikCa1rSHYWgnZXP~lCOAs75MvhlpKzcYywsT4a~satEDMWnBjK5qFC656QKETyVOvi3FN0WYXAuyG-RXhBRQ~QlFm~LbER5pes7KV3bubJ81QCQHxzAILvErtLl2FIfBI0LcswOIFLXqk2EM5jEW3LJ9OiQGIu90fgbJ5pt2f4HyjMSYM1kF~mUB-FXjbKp1jktu7T5876iEvLB6mqj7EuFz6wwjWB8WGJdjUhsCdBBGCJ1F-L2NtVcRkMJQe41d9WXCKerlERloI6vQng7WS4yaJYkzB~9PBqn5OsKbu3x7xAyp~3anOzPG0muWa0AdRcLVBP5b0Bnwgap0cBXg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Recruitment_of_bone_marrow_derived_valve_interstitial_cells_is_a_normal_homeostatic_process","translated_slug":"","page_count":22,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200599,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200599/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200599/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Recruitment_of_bone_marrow_derived_valve.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200599/ptpmcrender-libre.pdf?1661355226=\u0026response-content-disposition=attachment%3B+filename%3DRecruitment_of_bone_marrow_derived_valve.pdf\u0026Expires=1732499582\u0026Signature=adikCa1rSHYWgnZXP~lCOAs75MvhlpKzcYywsT4a~satEDMWnBjK5qFC656QKETyVOvi3FN0WYXAuyG-RXhBRQ~QlFm~LbER5pes7KV3bubJ81QCQHxzAILvErtLl2FIfBI0LcswOIFLXqk2EM5jEW3LJ9OiQGIu90fgbJ5pt2f4HyjMSYM1kF~mUB-FXjbKp1jktu7T5876iEvLB6mqj7EuFz6wwjWB8WGJdjUhsCdBBGCJ1F-L2NtVcRkMJQe41d9WXCKerlERloI6vQng7WS4yaJYkzB~9PBqn5OsKbu3x7xAyp~3anOzPG0muWa0AdRcLVBP5b0Bnwgap0cBXg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":50157,"name":"Molecular","url":"https://www.academia.edu/Documents/in/Molecular"},{"id":53113,"name":"Hematopoietic Stem Cells","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cells"},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":151086,"name":"Peptides","url":"https://www.academia.edu/Documents/in/Peptides"},{"id":159239,"name":"Bone marrow","url":"https://www.academia.edu/Documents/in/Bone_marrow"},{"id":191439,"name":"Glycoproteins","url":"https://www.academia.edu/Documents/in/Glycoproteins"},{"id":323415,"name":"Mouse Model","url":"https://www.academia.edu/Documents/in/Mouse_Model"},{"id":328063,"name":"Heart valves","url":"https://www.academia.edu/Documents/in/Heart_valves"},{"id":379889,"name":"Homeostasis","url":"https://www.academia.edu/Documents/in/Homeostasis"},{"id":405952,"name":"HSC","url":"https://www.academia.edu/Documents/in/HSC"},{"id":1311840,"name":"Heart Valve","url":"https://www.academia.edu/Documents/in/Heart_Valve"},{"id":1664707,"name":"Bone Marrow Cells","url":"https://www.academia.edu/Documents/in/Bone_Marrow_Cells"},{"id":1761225,"name":"Hematopoietic Stem Cell","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cell"},{"id":2374838,"name":"Hematopoietic Stem Cell Transplantation","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cell_Transplantation"},{"id":2481953,"name":"Cardiac function","url":"https://www.academia.edu/Documents/in/Cardiac_function"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"},{"id":4045206,"name":"Collagen type I","url":"https://www.academia.edu/Documents/in/Collagen_type_I"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528489"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528489/Cardiac_fibrosis_in_mice_with_hypertrophic_cardiomyopathy_is_mediated_by_non_myocyte_proliferation_and_requires_Tgf_%CE%B2"><img alt="Research paper thumbnail of Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β" class="work-thumbnail" src="https://attachments.academia-assets.com/90200536/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528489/Cardiac_fibrosis_in_mice_with_hypertrophic_cardiomyopathy_is_mediated_by_non_myocyte_proliferation_and_requires_Tgf_%CE%B2">Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β</a></div><div class="wp-workCard_item"><span>Journal of Clinical Investigation</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b318a13eea9d5ae847816f11488f012f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200536,"asset_id":85528489,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200536/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528489"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528489"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528489; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528489]").text(description); $(".js-view-count[data-work-id=85528489]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528489; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528489']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528489, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b318a13eea9d5ae847816f11488f012f" } } $('.js-work-strip[data-work-id=85528489]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528489,"title":"Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β","translated_title":"","metadata":{"publisher":"American Society for Clinical Investigation","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Journal of Clinical Investigation"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528489/Cardiac_fibrosis_in_mice_with_hypertrophic_cardiomyopathy_is_mediated_by_non_myocyte_proliferation_and_requires_Tgf_%CE%B2","translated_internal_url":"","created_at":"2022-08-24T07:48:07.785-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200536,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200536/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/90200536/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cardiac_fibrosis_in_mice_with_hypertroph.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200536/pdf-libre.pdf?1661355244=\u0026response-content-disposition=attachment%3B+filename%3DCardiac_fibrosis_in_mice_with_hypertroph.pdf\u0026Expires=1732499582\u0026Signature=UNDrGDkIu6K22HsMJ9nrCdtPjOR6-fK5xzFg0sABroW9IeUbAM4rQ74Q3n19Env-swjNFcBznoec0R-HPIpUKDDr87bAf4xmjqU6mN9PUTy2bV-92jKobb~IWB6V5Ht2Fm4AZEmedkTUZrSMawksXjXTkKH57wKaMrH7bIlTbcU2q~tsQMtRleRlLdqoG~F-KanEMoRdKqAJrwSaU6PUBJNE3RvlvPw-pMctLo2geBwbM6k0Ap18STT3tEk2oZ-vrKOtq7wKHHXydPsPFUIc3IftZbnRvVk1HFrTjKO1IlIBA-D0zP9BQZbyHCUFIqWkB~lnsXVuSYouGtVKvuyQKw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Cardiac_fibrosis_in_mice_with_hypertrophic_cardiomyopathy_is_mediated_by_non_myocyte_proliferation_and_requires_Tgf_β","translated_slug":"","page_count":10,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200536,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200536/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/90200536/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cardiac_fibrosis_in_mice_with_hypertroph.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200536/pdf-libre.pdf?1661355244=\u0026response-content-disposition=attachment%3B+filename%3DCardiac_fibrosis_in_mice_with_hypertroph.pdf\u0026Expires=1732499582\u0026Signature=UNDrGDkIu6K22HsMJ9nrCdtPjOR6-fK5xzFg0sABroW9IeUbAM4rQ74Q3n19Env-swjNFcBznoec0R-HPIpUKDDr87bAf4xmjqU6mN9PUTy2bV-92jKobb~IWB6V5Ht2Fm4AZEmedkTUZrSMawksXjXTkKH57wKaMrH7bIlTbcU2q~tsQMtRleRlLdqoG~F-KanEMoRdKqAJrwSaU6PUBJNE3RvlvPw-pMctLo2geBwbM6k0Ap18STT3tEk2oZ-vrKOtq7wKHHXydPsPFUIc3IftZbnRvVk1HFrTjKO1IlIBA-D0zP9BQZbyHCUFIqWkB~lnsXVuSYouGtVKvuyQKw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":130409,"name":"Research article","url":"https://www.academia.edu/Documents/in/Research_article"},{"id":174804,"name":"Fibrosis","url":"https://www.academia.edu/Documents/in/Fibrosis"},{"id":392828,"name":"Myocardium","url":"https://www.academia.edu/Documents/in/Myocardium"},{"id":423549,"name":"Cardiac Fibrosis","url":"https://www.academia.edu/Documents/in/Cardiac_Fibrosis"},{"id":527900,"name":"Transforming Growth Factor Beta","url":"https://www.academia.edu/Documents/in/Transforming_Growth_Factor_Beta"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation"},{"id":788694,"name":"Losartan","url":"https://www.academia.edu/Documents/in/Losartan"},{"id":916228,"name":"Hypertrophic Cardiomyopathy","url":"https://www.academia.edu/Documents/in/Hypertrophic_Cardiomyopathy"},{"id":1144154,"name":"Clinical Investigation","url":"https://www.academia.edu/Documents/in/Clinical_Investigation"},{"id":2616306,"name":"Myocardial fibrosis","url":"https://www.academia.edu/Documents/in/Myocardial_fibrosis"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528487"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528487/Towards_organ_printing_engineering_an_intra_organ_branched_vascular_tree"><img alt="Research paper thumbnail of Towards organ printing: engineering an intra-organ branched vascular tree" class="work-thumbnail" src="https://attachments.academia-assets.com/90200531/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528487/Towards_organ_printing_engineering_an_intra_organ_branched_vascular_tree">Towards organ printing: engineering an intra-organ branched vascular tree</a></div><div class="wp-workCard_item"><span>Expert Opinion on Biological Therapy</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="42d90984a777eb29ad4cdab84d729bb1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200531,"asset_id":85528487,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200531/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528487"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528487"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528487; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528487]").text(description); $(".js-view-count[data-work-id=85528487]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528487; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528487']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528487, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "42d90984a777eb29ad4cdab84d729bb1" } } $('.js-work-strip[data-work-id=85528487]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528487,"title":"Towards organ printing: engineering an intra-organ branched vascular tree","translated_title":"","metadata":{"publisher":"Informa Healthcare","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Expert Opinion on Biological Therapy"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528487/Towards_organ_printing_engineering_an_intra_organ_branched_vascular_tree","translated_internal_url":"","created_at":"2022-08-24T07:48:07.623-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200531,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200531/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200531/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Towards_organ_printing_engineering_an_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200531/ptpmcrender-libre.pdf?1661355227=\u0026response-content-disposition=attachment%3B+filename%3DTowards_organ_printing_engineering_an_in.pdf\u0026Expires=1732499582\u0026Signature=br6GWRmqwbjp0Wq3fpTY2Dw1hGVjkrdFYYUW1lPvUzQXLuZHi2OnG~A-uAxrN6fsxEWNUCIk1mdSKbL2LZSiptp2WZfzAAwFhuYMuCsJQRSJQ~TMYEuFK4ogfUeGvnjTj1bNobkaKZrdrr4PzR00wvkHqN3MH5H9MgHyUZkEMJJnR2TyKjVqf5hWq0hsgCTH839Tt0F~3OVeUIqFNkT592bfGUt9Q8dHyJdfE6crcoLbg0YZ8edc4~pTtfNC8JdoR2nafEaN4fZhFauTETCfsoEYsKRp8vJhGfO3BYkzbY88mARPI64M1rL3PUzwzS2jHfT1uNkZr3bNwcs9aRRlmw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Towards_organ_printing_engineering_an_intra_organ_branched_vascular_tree","translated_slug":"","page_count":21,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200531,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200531/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200531/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Towards_organ_printing_engineering_an_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200531/ptpmcrender-libre.pdf?1661355227=\u0026response-content-disposition=attachment%3B+filename%3DTowards_organ_printing_engineering_an_in.pdf\u0026Expires=1732499582\u0026Signature=br6GWRmqwbjp0Wq3fpTY2Dw1hGVjkrdFYYUW1lPvUzQXLuZHi2OnG~A-uAxrN6fsxEWNUCIk1mdSKbL2LZSiptp2WZfzAAwFhuYMuCsJQRSJQ~TMYEuFK4ogfUeGvnjTj1bNobkaKZrdrr4PzR00wvkHqN3MH5H9MgHyUZkEMJJnR2TyKjVqf5hWq0hsgCTH839Tt0F~3OVeUIqFNkT592bfGUt9Q8dHyJdfE6crcoLbg0YZ8edc4~pTtfNC8JdoR2nafEaN4fZhFauTETCfsoEYsKRp8vJhGfO3BYkzbY88mARPI64M1rL3PUzwzS2jHfT1uNkZr3bNwcs9aRRlmw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":77,"name":"Robotics","url":"https://www.academia.edu/Documents/in/Robotics"},{"id":2699,"name":"Tissue Engineering","url":"https://www.academia.edu/Documents/in/Tissue_Engineering"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":100540,"name":"Feasibility Studies","url":"https://www.academia.edu/Documents/in/Feasibility_Studies"},{"id":178994,"name":"Vascular tissue engineering","url":"https://www.academia.edu/Documents/in/Vascular_tissue_engineering"},{"id":216119,"name":"Biofabrication","url":"https://www.academia.edu/Documents/in/Biofabrication"},{"id":557543,"name":"Blood Vessels","url":"https://www.academia.edu/Documents/in/Blood_Vessels"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23312392,"url":"http://www.tandfonline.com/doi/pdf/10.1517/14712590903563352"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528485"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528485/American_Association_of_Anatomists_meeting_on_regenerative_medicine"><img alt="Research paper thumbnail of American Association of Anatomists meeting on regenerative medicine" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528485/American_Association_of_Anatomists_meeting_on_regenerative_medicine">American Association of Anatomists meeting on regenerative medicine</a></div><div class="wp-workCard_item"><span>Expert Opinion on Biological Therapy</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Several years ago, the American Association of Anatomists (AAA) launched an innovative mini-meeti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Several years ago, the American Association of Anatomists (AAA) launched an innovative mini-meeting format as part of their annual meeting. The AAA continued this tradition by sponsoring a 2-day mini-symposium as a part of its meeting at FASEB Experimental Biology, 2006 in San Francisco, CA, USA. This year, the mini-symposium was focused on the promising and rapidly developing field of &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;regenerative medicine&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;. The mini-symposium on &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;regenerative medicine&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; included four separate but thematically integrated sessions: stem cells for regenerative medicine; biomimetic matrices for regenerative medicine; endothelial-mesenchymal transformation in cardiovascular regenerative medicine; and tissue engineering technologies for regenerative medicine. The goal of these sessions was to identify progress and highlight new trends and directions in the evolving field of regenerative medicine. It was an exciting 2-day mini-symposium that reviewed the differential potential of embryonic and adult stem cells, their role in tissue turnover and possible applications in tissue regeneration; identified important evolving basic science issues, such as the role of endothelial-mesenchymal transformation and stem cell recruitment in cardiovascular regenerative medicine; and, finally, clearly demonstrated how understanding basic scientific principles can be translated into novel cell therapeutics and tissue engineering modalities. The workshop also demonstrated the multidisciplinary (speakers included stem cell and developmental biologists, chemical engineers, tissue engineers, biophysicists, mathematicians and surgeons) and international (speakers represented US, Japan, Canada, Switzerland and Korea) character of ongoing efforts in the area of regenerative medicine and stem cell biology, impressive progress in this field, and confirmed the strong potential for clinical translation of emerging regenerative medicine technologies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528485"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528485"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528485; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528485]").text(description); $(".js-view-count[data-work-id=85528485]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528485; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528485']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528485, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85528485]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528485,"title":"American Association of Anatomists meeting on regenerative medicine","translated_title":"","metadata":{"abstract":"Several years ago, the American Association of Anatomists (AAA) launched an innovative mini-meeting format as part of their annual meeting. The AAA continued this tradition by sponsoring a 2-day mini-symposium as a part of its meeting at FASEB Experimental Biology, 2006 in San Francisco, CA, USA. This year, the mini-symposium was focused on the promising and rapidly developing field of \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;regenerative medicine\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;. The mini-symposium on \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;regenerative medicine\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; included four separate but thematically integrated sessions: stem cells for regenerative medicine; biomimetic matrices for regenerative medicine; endothelial-mesenchymal transformation in cardiovascular regenerative medicine; and tissue engineering technologies for regenerative medicine. The goal of these sessions was to identify progress and highlight new trends and directions in the evolving field of regenerative medicine. It was an exciting 2-day mini-symposium that reviewed the differential potential of embryonic and adult stem cells, their role in tissue turnover and possible applications in tissue regeneration; identified important evolving basic science issues, such as the role of endothelial-mesenchymal transformation and stem cell recruitment in cardiovascular regenerative medicine; and, finally, clearly demonstrated how understanding basic scientific principles can be translated into novel cell therapeutics and tissue engineering modalities. The workshop also demonstrated the multidisciplinary (speakers included stem cell and developmental biologists, chemical engineers, tissue engineers, biophysicists, mathematicians and surgeons) and international (speakers represented US, Japan, Canada, Switzerland and Korea) character of ongoing efforts in the area of regenerative medicine and stem cell biology, impressive progress in this field, and confirmed the strong potential for clinical translation of emerging regenerative medicine technologies.","publisher":"Informa Healthcare","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Expert Opinion on Biological Therapy"},"translated_abstract":"Several years ago, the American Association of Anatomists (AAA) launched an innovative mini-meeting format as part of their annual meeting. The AAA continued this tradition by sponsoring a 2-day mini-symposium as a part of its meeting at FASEB Experimental Biology, 2006 in San Francisco, CA, USA. This year, the mini-symposium was focused on the promising and rapidly developing field of \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;regenerative medicine\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;. The mini-symposium on \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;regenerative medicine\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; included four separate but thematically integrated sessions: stem cells for regenerative medicine; biomimetic matrices for regenerative medicine; endothelial-mesenchymal transformation in cardiovascular regenerative medicine; and tissue engineering technologies for regenerative medicine. The goal of these sessions was to identify progress and highlight new trends and directions in the evolving field of regenerative medicine. It was an exciting 2-day mini-symposium that reviewed the differential potential of embryonic and adult stem cells, their role in tissue turnover and possible applications in tissue regeneration; identified important evolving basic science issues, such as the role of endothelial-mesenchymal transformation and stem cell recruitment in cardiovascular regenerative medicine; and, finally, clearly demonstrated how understanding basic scientific principles can be translated into novel cell therapeutics and tissue engineering modalities. The workshop also demonstrated the multidisciplinary (speakers included stem cell and developmental biologists, chemical engineers, tissue engineers, biophysicists, mathematicians and surgeons) and international (speakers represented US, Japan, Canada, Switzerland and Korea) character of ongoing efforts in the area of regenerative medicine and stem cell biology, impressive progress in this field, and confirmed the strong potential for clinical translation of emerging regenerative medicine technologies.","internal_url":"https://www.academia.edu/85528485/American_Association_of_Anatomists_meeting_on_regenerative_medicine","translated_internal_url":"","created_at":"2022-08-24T07:48:07.477-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"American_Association_of_Anatomists_meeting_on_regenerative_medicine","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[],"research_interests":[{"id":2699,"name":"Tissue Engineering","url":"https://www.academia.edu/Documents/in/Tissue_Engineering"},{"id":3642,"name":"Stem Cells","url":"https://www.academia.edu/Documents/in/Stem_Cells"},{"id":25550,"name":"Regenerative Medicine","url":"https://www.academia.edu/Documents/in/Regenerative_Medicine"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":54589,"name":"Anatomy","url":"https://www.academia.edu/Documents/in/Anatomy"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98134,"name":"United States","url":"https://www.academia.edu/Documents/in/United_States"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23312391,"url":"http://www.tandfonline.com/doi/pdf/10.1517/14712598.6.7.727"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528484"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528484/What_is_regenerative_medicine_Emergence_of_applied_stem_cell_and_developmental_biology"><img alt="Research paper thumbnail of What is regenerative medicine? Emergence of applied stem cell and developmental biology" class="work-thumbnail" src="https://attachments.academia-assets.com/90200529/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528484/What_is_regenerative_medicine_Emergence_of_applied_stem_cell_and_developmental_biology">What is regenerative medicine? Emergence of applied stem cell and developmental biology</a></div><div class="wp-workCard_item"><span>Expert Opinion on Biological Therapy</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="03c851b343cc8e8d7c7614cb67ecfec8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200529,"asset_id":85528484,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200529/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528484"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528484"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528484; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528484]").text(description); $(".js-view-count[data-work-id=85528484]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528484; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528484']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528484, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "03c851b343cc8e8d7c7614cb67ecfec8" } } $('.js-work-strip[data-work-id=85528484]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528484,"title":"What is regenerative medicine? Emergence of applied stem cell and developmental biology","translated_title":"","metadata":{"publisher":"Informa Healthcare","publication_date":{"day":null,"month":null,"year":2004,"errors":{}},"publication_name":"Expert Opinion on Biological Therapy"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528484/What_is_regenerative_medicine_Emergence_of_applied_stem_cell_and_developmental_biology","translated_internal_url":"","created_at":"2022-08-24T07:48:07.324-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200529,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200529/thumbnails/1.jpg","file_name":"14712598.4.6.77320220824-1-mjc6zs.pdf","download_url":"https://www.academia.edu/attachments/90200529/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"What_is_regenerative_medicine_Emergence.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200529/14712598.4.6.77320220824-1-mjc6zs-libre.pdf?1661355232=\u0026response-content-disposition=attachment%3B+filename%3DWhat_is_regenerative_medicine_Emergence.pdf\u0026Expires=1732499583\u0026Signature=erjYIuIogiNGmfu80QxwEhV1c2i7AWI-87QNu1aAnOJyNEuHrEqeeTEQxBs33zALA5cMN-sRsuERd1k-CvgPyYovQ54zccrKvK~D0KE7IokDJK5fI1cWHee3NkgvQ17~ppzFOgX4aefE5GVOvB~XyEAINYXi0JDweKbvzDUb64mtCd2wySSfsksfg2amnXfCg0vI1MkaEMN94Tu0GNvjRCKppc46h0sIkbvOqYRPawhYs5ofDJANGtPSOcafR-Fdj9BGE6NdJTEXio2-hxBRSa6cY7Wp-3VqCmG756thl7R6tkl3~CvJDa3wqVPnRRi6EBfPRibobaEMULVgSSrxYQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"What_is_regenerative_medicine_Emergence_of_applied_stem_cell_and_developmental_biology","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200529,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200529/thumbnails/1.jpg","file_name":"14712598.4.6.77320220824-1-mjc6zs.pdf","download_url":"https://www.academia.edu/attachments/90200529/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"What_is_regenerative_medicine_Emergence.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200529/14712598.4.6.77320220824-1-mjc6zs-libre.pdf?1661355232=\u0026response-content-disposition=attachment%3B+filename%3DWhat_is_regenerative_medicine_Emergence.pdf\u0026Expires=1732499583\u0026Signature=erjYIuIogiNGmfu80QxwEhV1c2i7AWI-87QNu1aAnOJyNEuHrEqeeTEQxBs33zALA5cMN-sRsuERd1k-CvgPyYovQ54zccrKvK~D0KE7IokDJK5fI1cWHee3NkgvQ17~ppzFOgX4aefE5GVOvB~XyEAINYXi0JDweKbvzDUb64mtCd2wySSfsksfg2amnXfCg0vI1MkaEMN94Tu0GNvjRCKppc46h0sIkbvOqYRPawhYs5ofDJANGtPSOcafR-Fdj9BGE6NdJTEXio2-hxBRSa6cY7Wp-3VqCmG756thl7R6tkl3~CvJDa3wqVPnRRi6EBfPRibobaEMULVgSSrxYQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":23163,"name":"Stem Cell","url":"https://www.academia.edu/Documents/in/Stem_Cell"},{"id":25550,"name":"Regenerative Medicine","url":"https://www.academia.edu/Documents/in/Regenerative_Medicine"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23312390,"url":"http://www.tandfonline.com/doi/pdf/10.1517/14712598.4.6.773"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528483"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528483/On_the_Role_of_Shear_Stress_in_Cardiogenesis"><img alt="Research paper thumbnail of On the Role of Shear Stress in Cardiogenesis" class="work-thumbnail" src="https://attachments.academia-assets.com/90200530/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528483/On_the_Role_of_Shear_Stress_in_Cardiogenesis">On the Role of Shear Stress in Cardiogenesis</a></div><div class="wp-workCard_item"><span>Endothelium</span><span>, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="df8d3c871d1b349c5fcc63ffd0f65682" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200530,"asset_id":85528483,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200530/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528483"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528483"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528483; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528483]").text(description); $(".js-view-count[data-work-id=85528483]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528483; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528483']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528483, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "df8d3c871d1b349c5fcc63ffd0f65682" } } $('.js-work-strip[data-work-id=85528483]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528483,"title":"On the Role of Shear Stress in Cardiogenesis","translated_title":"","metadata":{"publisher":"Informa UK Limited","publication_date":{"day":null,"month":null,"year":2005,"errors":{}},"publication_name":"Endothelium"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528483/On_the_Role_of_Shear_Stress_in_Cardiogenesis","translated_internal_url":"","created_at":"2022-08-24T07:48:07.128-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200530,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200530/thumbnails/1.jpg","file_name":"1062332050047670820220824-1-1qu6kz9.pdf","download_url":"https://www.academia.edu/attachments/90200530/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"On_the_Role_of_Shear_Stress_in_Cardiogen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200530/1062332050047670820220824-1-1qu6kz9-libre.pdf?1661355226=\u0026response-content-disposition=attachment%3B+filename%3DOn_the_Role_of_Shear_Stress_in_Cardiogen.pdf\u0026Expires=1732499583\u0026Signature=Zt5swWhMIJvoWJ4MuagJRCpWVlJ8GG6-Z8O4Zac~j-42J9-qpy3nKst9~oaB0-QjqgjHto2S5Mrgi5xZ~szPLPnCpB35aVLet-kAIXpEZAECRUW6vUnjj~VAENxhXUC0I8ki70roLMupfiU5lj4jeAuRX0npKvwkSzoLeHwGuYeczH9mA4lSbwZy8t9K9QOC14luGmg8KJi1FTZX0~jJLKk7Q8OR8VJI4x2JA14UZ3MPqhHRepBh129hbP~-PDFtd7o-DV0f8oEHeg9KapoOesrWIx6d4NukbBVeJwJZxTePLDadlZFrmcjX1DNacuY03c-ME7KtwyL11DAXzkljjA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"On_the_Role_of_Shear_Stress_in_Cardiogenesis","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200530,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200530/thumbnails/1.jpg","file_name":"1062332050047670820220824-1-1qu6kz9.pdf","download_url":"https://www.academia.edu/attachments/90200530/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"On_the_Role_of_Shear_Stress_in_Cardiogen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200530/1062332050047670820220824-1-1qu6kz9-libre.pdf?1661355226=\u0026response-content-disposition=attachment%3B+filename%3DOn_the_Role_of_Shear_Stress_in_Cardiogen.pdf\u0026Expires=1732499583\u0026Signature=Zt5swWhMIJvoWJ4MuagJRCpWVlJ8GG6-Z8O4Zac~j-42J9-qpy3nKst9~oaB0-QjqgjHto2S5Mrgi5xZ~szPLPnCpB35aVLet-kAIXpEZAECRUW6vUnjj~VAENxhXUC0I8ki70roLMupfiU5lj4jeAuRX0npKvwkSzoLeHwGuYeczH9mA4lSbwZy8t9K9QOC14luGmg8KJi1FTZX0~jJLKk7Q8OR8VJI4x2JA14UZ3MPqhHRepBh129hbP~-PDFtd7o-DV0f8oEHeg9KapoOesrWIx6d4NukbBVeJwJZxTePLDadlZFrmcjX1DNacuY03c-ME7KtwyL11DAXzkljjA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":131495,"name":"Heart","url":"https://www.academia.edu/Documents/in/Heart"},{"id":175859,"name":"Shear Stress","url":"https://www.academia.edu/Documents/in/Shear_Stress"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":350931,"name":"Mechanical Stress","url":"https://www.academia.edu/Documents/in/Mechanical_Stress"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1"},{"id":788667,"name":"ENDOTHELIUM","url":"https://www.academia.edu/Documents/in/ENDOTHELIUM"},{"id":908227,"name":"Organogenesis","url":"https://www.academia.edu/Documents/in/Organogenesis"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":23312389,"url":"http://www.tandfonline.com/doi/pdf/10.1080/10623320500476708"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528482"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528482/Atrioventricular_valve_development_New_perspectives_on_an_old_theme"><img alt="Research paper thumbnail of Atrioventricular valve development: New perspectives on an old theme" class="work-thumbnail" src="https://attachments.academia-assets.com/90200594/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528482/Atrioventricular_valve_development_New_perspectives_on_an_old_theme">Atrioventricular valve development: New perspectives on an old theme</a></div><div class="wp-workCard_item"><span>Differentiation</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="589eded4a5476665474b4e3d0ce78403" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200594,"asset_id":85528482,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200594/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528482"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528482"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528482; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528482]").text(description); $(".js-view-count[data-work-id=85528482]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528482; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528482']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528482, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "589eded4a5476665474b4e3d0ce78403" } } $('.js-work-strip[data-work-id=85528482]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528482,"title":"Atrioventricular valve development: New perspectives on an old theme","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Differentiation"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528482/Atrioventricular_valve_development_New_perspectives_on_an_old_theme","translated_internal_url":"","created_at":"2022-08-24T07:48:06.984-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200594,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200594/thumbnails/1.jpg","file_name":"j.diff.2012.04.00120220824-1-1tnfrda.pdf","download_url":"https://www.academia.edu/attachments/90200594/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Atrioventricular_valve_development_New_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200594/j.diff.2012.04.00120220824-1-1tnfrda-libre.pdf?1661355222=\u0026response-content-disposition=attachment%3B+filename%3DAtrioventricular_valve_development_New_p.pdf\u0026Expires=1732499583\u0026Signature=hSuIZGmewROi5ISrbVlvxD7dlE3aHb2Ij-rLzO1mupkqgmkHLeg~0jZcoGp~azOuDvAiiHiBnn3rYECTBRDU75E~28sro~qKKAffrurYl7vH8VrFCzf3pJltfykcHwkIxCGp9qb~HPqtIF9nYT8U8mapKV-ez3J9t7TWtnR3jnYt1omLZc6FOtc-e511pX00Z5PYneRcUXulX0i6YCkHKhBLxWZliJL78yGRMluacY6jI4JXBZpo1h8GWk-fe~KbTF11d-lG-o8m-A0d6wxepBb05YSUURmLE4-5wEVJe4jIbNDFNzlszIOmfanMU-5xo3~Y95tmfyAMAf-u2b~evA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Atrioventricular_valve_development_New_perspectives_on_an_old_theme","translated_slug":"","page_count":14,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200594,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200594/thumbnails/1.jpg","file_name":"j.diff.2012.04.00120220824-1-1tnfrda.pdf","download_url":"https://www.academia.edu/attachments/90200594/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Atrioventricular_valve_development_New_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200594/j.diff.2012.04.00120220824-1-1tnfrda-libre.pdf?1661355222=\u0026response-content-disposition=attachment%3B+filename%3DAtrioventricular_valve_development_New_p.pdf\u0026Expires=1732499583\u0026Signature=hSuIZGmewROi5ISrbVlvxD7dlE3aHb2Ij-rLzO1mupkqgmkHLeg~0jZcoGp~azOuDvAiiHiBnn3rYECTBRDU75E~28sro~qKKAffrurYl7vH8VrFCzf3pJltfykcHwkIxCGp9qb~HPqtIF9nYT8U8mapKV-ez3J9t7TWtnR3jnYt1omLZc6FOtc-e511pX00Z5PYneRcUXulX0i6YCkHKhBLxWZliJL78yGRMluacY6jI4JXBZpo1h8GWk-fe~KbTF11d-lG-o8m-A0d6wxepBb05YSUURmLE4-5wEVJe4jIbNDFNzlszIOmfanMU-5xo3~Y95tmfyAMAf-u2b~evA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":29149,"name":"Extracellular Matrix","url":"https://www.academia.edu/Documents/in/Extracellular_Matrix"},{"id":57980,"name":"Congenital Heart Defects","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Defects"},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":71510,"name":"Endothelial Cells","url":"https://www.academia.edu/Documents/in/Endothelial_Cells"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":194810,"name":"Differentiation","url":"https://www.academia.edu/Documents/in/Differentiation"},{"id":231933,"name":"Mitral Valve Repair","url":"https://www.academia.edu/Documents/in/Mitral_Valve_Repair"},{"id":328063,"name":"Heart valves","url":"https://www.academia.edu/Documents/in/Heart_valves"},{"id":954995,"name":"Human Fibroblasts","url":"https://www.academia.edu/Documents/in/Human_Fibroblasts"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":2533047,"name":"fibroblasts","url":"https://www.academia.edu/Documents/in/fibroblasts"},{"id":3675689,"name":"Chick embryo","url":"https://www.academia.edu/Documents/in/Chick_embryo"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"},{"id":3910249,"name":"endocardium","url":"https://www.academia.edu/Documents/in/endocardium"},{"id":4045206,"name":"Collagen type I","url":"https://www.academia.edu/Documents/in/Collagen_type_I"},{"id":4114205,"name":"Mitral valve","url":"https://www.academia.edu/Documents/in/Mitral_valve-1"}],"urls":[{"id":23312388,"url":"https://api.elsevier.com/content/article/PII:S030146811200062X?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528481"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528481/Organ_printing_Tissue_spheroids_as_building_blocks"><img alt="Research paper thumbnail of Organ printing: Tissue spheroids as building blocks" class="work-thumbnail" src="https://attachments.academia-assets.com/90200532/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528481/Organ_printing_Tissue_spheroids_as_building_blocks">Organ printing: Tissue spheroids as building blocks</a></div><div class="wp-workCard_item"><span>Biomaterials</span><span>, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ccd5a0488494255fa8de3483821cbbd1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200532,"asset_id":85528481,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200532/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528481"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528481"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528481; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528481]").text(description); $(".js-view-count[data-work-id=85528481]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528481; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528481']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528481, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ccd5a0488494255fa8de3483821cbbd1" } } $('.js-work-strip[data-work-id=85528481]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528481,"title":"Organ printing: Tissue spheroids as building blocks","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"Biomaterials"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528481/Organ_printing_Tissue_spheroids_as_building_blocks","translated_internal_url":"","created_at":"2022-08-24T07:48:06.828-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200532,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200532/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200532/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Organ_printing_Tissue_spheroids_as_build.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200532/ptpmcrender.pdf?1661352555=\u0026response-content-disposition=attachment%3B+filename%3DOrgan_printing_Tissue_spheroids_as_build.pdf\u0026Expires=1732499583\u0026Signature=VnldKor9L0Nt4WyQuG3mD~J9lpfUUwYiqYXgwkJdLkID9xLs~DVNBm2QdVUy2xmiPGI2qMiiWl0XYYRGAB~-QbxbipYzDDNy7iG5q7nLbF2atuePkIOAFk7U~Bxm7~FeBF0zghUfEosOaJM1A6Ww9O3CoAeRnm5NHGlMgp-l4W28WYeLek-eHw8hX8c4Rbj-sLmnonjKbsGVjkNCVnHr2pQavhPL1WCTxdnDpkYAfFe1ei3BsbO2TheONzlh3g~zmS2FXfCLp6e2wfLb6s-H7ewMN7mm8xESbQKhEYjJDSNprs3s782dIiSqMCPyG1NaL1xOEqaYzO-Ls8hKbzmGxw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Organ_printing_Tissue_spheroids_as_building_blocks","translated_slug":"","page_count":22,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200532,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200532/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200532/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Organ_printing_Tissue_spheroids_as_build.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200532/ptpmcrender.pdf?1661352555=\u0026response-content-disposition=attachment%3B+filename%3DOrgan_printing_Tissue_spheroids_as_build.pdf\u0026Expires=1732499583\u0026Signature=VnldKor9L0Nt4WyQuG3mD~J9lpfUUwYiqYXgwkJdLkID9xLs~DVNBm2QdVUy2xmiPGI2qMiiWl0XYYRGAB~-QbxbipYzDDNy7iG5q7nLbF2atuePkIOAFk7U~Bxm7~FeBF0zghUfEosOaJM1A6Ww9O3CoAeRnm5NHGlMgp-l4W28WYeLek-eHw8hX8c4Rbj-sLmnonjKbsGVjkNCVnHr2pQavhPL1WCTxdnDpkYAfFe1ei3BsbO2TheONzlh3g~zmS2FXfCLp6e2wfLb6s-H7ewMN7mm8xESbQKhEYjJDSNprs3s782dIiSqMCPyG1NaL1xOEqaYzO-Ls8hKbzmGxw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1083,"name":"Developmental Biology","url":"https://www.academia.edu/Documents/in/Developmental_Biology"},{"id":2698,"name":"Biomaterials","url":"https://www.academia.edu/Documents/in/Biomaterials"},{"id":2699,"name":"Tissue Engineering","url":"https://www.academia.edu/Documents/in/Tissue_Engineering"},{"id":11073,"name":"Self Assembly","url":"https://www.academia.edu/Documents/in/Self_Assembly"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":69542,"name":"Computer Simulation","url":"https://www.academia.edu/Documents/in/Computer_Simulation"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":169323,"name":"Composite Material","url":"https://www.academia.edu/Documents/in/Composite_Material"},{"id":188197,"name":"Industrial Robots","url":"https://www.academia.edu/Documents/in/Industrial_Robots"},{"id":401996,"name":"Layer by Layer","url":"https://www.academia.edu/Documents/in/Layer_by_Layer"},{"id":451298,"name":"3-D printing","url":"https://www.academia.edu/Documents/in/3-D_printing"},{"id":504035,"name":"Three Dimensional","url":"https://www.academia.edu/Documents/in/Three_Dimensional"},{"id":758278,"name":"Large Scale","url":"https://www.academia.edu/Documents/in/Large_Scale"}],"urls":[{"id":23312387,"url":"https://api.elsevier.com/content/article/PII:S0142961209000052?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528460"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528460/An_In_Vivo_Analysis_of_Hematopoietic_Stem_Cell_Potential"><img alt="Research paper thumbnail of An In Vivo Analysis of Hematopoietic Stem Cell Potential" class="work-thumbnail" src="https://attachments.academia-assets.com/90200559/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528460/An_In_Vivo_Analysis_of_Hematopoietic_Stem_Cell_Potential">An In Vivo Analysis of Hematopoietic Stem Cell Potential</a></div><div class="wp-workCard_item"><span>Circulation Research</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Recent studies evaluating hematopoietic stem cell (HSC) potential raise the possibility that, in ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Recent studies evaluating hematopoietic stem cell (HSC) potential raise the possibility that, in addition to embryonic sources, adult valve fibroblasts may be derived from HSCs. To test this hypothesis, we used methods that allow the potential of a single HSC to be evaluated in vivo. This was achieved by isolation and clonal expansion of single lineage-negative (Lin − ), c-kit + , Sca-1 + , CD34 − cells from the bone marrow of mice that ubiquitously express enhanced green fluorescent protein (EGFP) combined with transplantation of individual clonal populations derived from these candidate HSCs into a lethally irradiated congenic non-EGFP mouse. Histological analyses of valve tissue from clonally engrafted recipient mice revealed the presence of numerous EGFP + cells within host valves. A subpopulation of these cells exhibited synthetic properties characteristic of fibroblasts, as evidenced by their expression of mRNA for procollagen 1α1. Further, we show by Y-chromosome–specific flu...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4f00fd41c2685a20a9a0bfdba6419236" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200559,"asset_id":85528460,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200559/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528460"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528460"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528460; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528460]").text(description); $(".js-view-count[data-work-id=85528460]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528460; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528460']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528460, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4f00fd41c2685a20a9a0bfdba6419236" } } $('.js-work-strip[data-work-id=85528460]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528460,"title":"An In Vivo Analysis of Hematopoietic Stem Cell Potential","translated_title":"","metadata":{"abstract":"Recent studies evaluating hematopoietic stem cell (HSC) potential raise the possibility that, in addition to embryonic sources, adult valve fibroblasts may be derived from HSCs. To test this hypothesis, we used methods that allow the potential of a single HSC to be evaluated in vivo. This was achieved by isolation and clonal expansion of single lineage-negative (Lin − ), c-kit + , Sca-1 + , CD34 − cells from the bone marrow of mice that ubiquitously express enhanced green fluorescent protein (EGFP) combined with transplantation of individual clonal populations derived from these candidate HSCs into a lethally irradiated congenic non-EGFP mouse. Histological analyses of valve tissue from clonally engrafted recipient mice revealed the presence of numerous EGFP + cells within host valves. A subpopulation of these cells exhibited synthetic properties characteristic of fibroblasts, as evidenced by their expression of mRNA for procollagen 1α1. Further, we show by Y-chromosome–specific flu...","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Circulation Research"},"translated_abstract":"Recent studies evaluating hematopoietic stem cell (HSC) potential raise the possibility that, in addition to embryonic sources, adult valve fibroblasts may be derived from HSCs. To test this hypothesis, we used methods that allow the potential of a single HSC to be evaluated in vivo. This was achieved by isolation and clonal expansion of single lineage-negative (Lin − ), c-kit + , Sca-1 + , CD34 − cells from the bone marrow of mice that ubiquitously express enhanced green fluorescent protein (EGFP) combined with transplantation of individual clonal populations derived from these candidate HSCs into a lethally irradiated congenic non-EGFP mouse. Histological analyses of valve tissue from clonally engrafted recipient mice revealed the presence of numerous EGFP + cells within host valves. A subpopulation of these cells exhibited synthetic properties characteristic of fibroblasts, as evidenced by their expression of mRNA for procollagen 1α1. Further, we show by Y-chromosome–specific flu...","internal_url":"https://www.academia.edu/85528460/An_In_Vivo_Analysis_of_Hematopoietic_Stem_Cell_Potential","translated_internal_url":"","created_at":"2022-08-24T07:47:35.003-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200559,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200559/thumbnails/1.jpg","file_name":"690.full.pdf","download_url":"https://www.academia.edu/attachments/90200559/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"An_In_Vivo_Analysis_of_Hematopoietic_Ste.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200559/690.full-libre.pdf?1661355224=\u0026response-content-disposition=attachment%3B+filename%3DAn_In_Vivo_Analysis_of_Hematopoietic_Ste.pdf\u0026Expires=1732499583\u0026Signature=ZgS8OD9d2pjf1w~H3iLg7ixmEOW~UdHDbAdAYnh257HuhitkxXefmeYMF65LBfvbfQSUULUr64ooY8NRP0xlnsBMW4ZCDu2t8g4aKe1eWX~-IqORdDE3JvKmKTuJ~lCjWG2Rlc2d-v~WkxbVTJrAaPG~Y~5SYaaU5BUZege2x1ilHz8seh4INokbvdvF1LcUQmrv82EcVf~3tY510ojujLKgxPm1zunsm26yG16W9dGGOPA~ZZE-CLNo0pL3NtVcHq~XO9LKg6ZzpnlFcgNaZp0d8d2D63fZyqBWn~9UdQp5JjDTLFPt7-D3ytb6SAY5BYuoLwPpE1olo9kFM4n~Gg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"An_In_Vivo_Analysis_of_Hematopoietic_Stem_Cell_Potential","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200559,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200559/thumbnails/1.jpg","file_name":"690.full.pdf","download_url":"https://www.academia.edu/attachments/90200559/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"An_In_Vivo_Analysis_of_Hematopoietic_Ste.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200559/690.full-libre.pdf?1661355224=\u0026response-content-disposition=attachment%3B+filename%3DAn_In_Vivo_Analysis_of_Hematopoietic_Ste.pdf\u0026Expires=1732499583\u0026Signature=ZgS8OD9d2pjf1w~H3iLg7ixmEOW~UdHDbAdAYnh257HuhitkxXefmeYMF65LBfvbfQSUULUr64ooY8NRP0xlnsBMW4ZCDu2t8g4aKe1eWX~-IqORdDE3JvKmKTuJ~lCjWG2Rlc2d-v~WkxbVTJrAaPG~Y~5SYaaU5BUZege2x1ilHz8seh4INokbvdvF1LcUQmrv82EcVf~3tY510ojujLKgxPm1zunsm26yG16W9dGGOPA~ZZE-CLNo0pL3NtVcHq~XO9LKg6ZzpnlFcgNaZp0d8d2D63fZyqBWn~9UdQp5JjDTLFPt7-D3ytb6SAY5BYuoLwPpE1olo9kFM4n~Gg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":18608,"name":"Adult Stem Cells","url":"https://www.academia.edu/Documents/in/Adult_Stem_Cells"},{"id":37866,"name":"Hematopoiesis","url":"https://www.academia.edu/Documents/in/Hematopoiesis"},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":159239,"name":"Bone marrow","url":"https://www.academia.edu/Documents/in/Bone_marrow"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":302037,"name":"In Vivo","url":"https://www.academia.edu/Documents/in/In_Vivo"},{"id":328063,"name":"Heart valves","url":"https://www.academia.edu/Documents/in/Heart_valves"},{"id":376291,"name":"Fluorescent in situ hybridization","url":"https://www.academia.edu/Documents/in/Fluorescent_in_situ_hybridization"},{"id":515070,"name":"Circulation","url":"https://www.academia.edu/Documents/in/Circulation"},{"id":954995,"name":"Human Fibroblasts","url":"https://www.academia.edu/Documents/in/Human_Fibroblasts"},{"id":1320085,"name":"Adult Stem Cell","url":"https://www.academia.edu/Documents/in/Adult_Stem_Cell"},{"id":1761225,"name":"Hematopoietic Stem Cell","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cell"},{"id":2374838,"name":"Hematopoietic Stem Cell Transplantation","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cell_Transplantation"},{"id":2533047,"name":"fibroblasts","url":"https://www.academia.edu/Documents/in/fibroblasts"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"},{"id":4045206,"name":"Collagen type I","url":"https://www.academia.edu/Documents/in/Collagen_type_I"}],"urls":[{"id":23312378,"url":"https://www.ahajournals.org/doi/full/10.1161/01.RES.0000207384.81818.d4"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="50021670"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/50021670/Regulation_of_Myocardium_Formation_after_the_Initial_Development_of_the_Linear_Heart_Tube"><img alt="Research paper thumbnail of Regulation of Myocardium Formation after the Initial Development of the Linear Heart Tube" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/50021670/Regulation_of_Myocardium_Formation_after_the_Initial_Development_of_the_Linear_Heart_Tube">Regulation of Myocardium Formation after the Initial Development of the Linear Heart Tube</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AMoorman1">A. Moorman</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RogerMarkwald">Roger Markwald</a></span></div><div class="wp-workCard_item"><span>Cardiovascular Development and Congenital Malformations</span><span>, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="50021670"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="50021670"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 50021670; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=50021670]").text(description); $(".js-view-count[data-work-id=50021670]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 50021670; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='50021670']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 50021670, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=50021670]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":50021670,"title":"Regulation of Myocardium Formation after the Initial Development of the Linear Heart Tube","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2005,"errors":{}},"publication_name":"Cardiovascular Development and Congenital Malformations"},"translated_abstract":null,"internal_url":"https://www.academia.edu/50021670/Regulation_of_Myocardium_Formation_after_the_Initial_Development_of_the_Linear_Heart_Tube","translated_internal_url":"","created_at":"2021-07-17T10:14:15.710-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46673754,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":38416531,"work_id":50021670,"tagging_user_id":46673754,"tagged_user_id":46881112,"co_author_invite_id":null,"email":"m***f@amc.nl","affiliation":"Academic Medical Centre/ Universiteit van Amsterdam","display_order":0,"name":"Maurice Van Den Hoff","title":"Regulation of Myocardium Formation after the Initial Development of the Linear Heart Tube"},{"id":38416533,"work_id":50021670,"tagging_user_id":46673754,"tagged_user_id":null,"co_author_invite_id":774572,"email":"b***f@lumc.nl","display_order":6291456,"name":"Boudewijn Kruithof","title":"Regulation of Myocardium Formation after the Initial Development of the Linear Heart Tube"},{"id":38416536,"work_id":50021670,"tagging_user_id":46673754,"tagged_user_id":null,"co_author_invite_id":3292114,"email":"w***a@musc.edu","display_order":7340032,"name":"Andy Wessels","title":"Regulation of Myocardium Formation after the Initial Development of the Linear Heart Tube"},{"id":38416537,"work_id":50021670,"tagging_user_id":46673754,"tagged_user_id":38217099,"co_author_invite_id":null,"email":"m***d@musc.edu","display_order":7864320,"name":"Roger Markwald","title":"Regulation of Myocardium Formation after the Initial Development of the Linear Heart Tube"}],"downloadable_attachments":[],"slug":"Regulation_of_Myocardium_Formation_after_the_Initial_Development_of_the_Linear_Heart_Tube","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":46673754,"first_name":"A.","middle_initials":null,"last_name":"Moorman","page_name":"AMoorman1","domain_name":"independent","created_at":"2016-04-08T13:27:11.512-07:00","display_name":"A. Moorman","url":"https://independent.academia.edu/AMoorman1"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="80012400"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/80012400/Periostin_regulates_collagen_fibrillogenesis_and_the_biomechanical_properties_of_connective_tissues"><img alt="Research paper thumbnail of Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues" class="work-thumbnail" src="https://attachments.academia-assets.com/86535526/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/80012400/Periostin_regulates_collagen_fibrillogenesis_and_the_biomechanical_properties_of_connective_tissues">Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues</a></div><div class="wp-workCard_item"><span>Journal of Cellular Biochemistry</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b7549c4733e7fabbef44fc154e4df7ee" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86535526,"asset_id":80012400,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86535526/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="80012400"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="80012400"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80012400; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=80012400]").text(description); $(".js-view-count[data-work-id=80012400]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 80012400; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='80012400']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 80012400, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b7549c4733e7fabbef44fc154e4df7ee" } } $('.js-work-strip[data-work-id=80012400]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":80012400,"title":"Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues","translated_title":"","metadata":{"publisher":"Wiley","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Journal of Cellular Biochemistry"},"translated_abstract":null,"internal_url":"https://www.academia.edu/80012400/Periostin_regulates_collagen_fibrillogenesis_and_the_biomechanical_properties_of_connective_tissues","translated_internal_url":"","created_at":"2022-05-26T22:27:28.997-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":86535526,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86535526/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/86535526/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Periostin_regulates_collagen_fibrillogen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86535526/ptpmcrender-libre.pdf?1653629819=\u0026response-content-disposition=attachment%3B+filename%3DPeriostin_regulates_collagen_fibrillogen.pdf\u0026Expires=1732499583\u0026Signature=I6YI8XYiuGrUBsuXtU4rv1C4PrE1YUOjhWa93Wnvhk-LJfEcWlMzQfYWMMFW4lw0OymX1RIHCZN8zlwP~tC~Vs-ijMySNqfptKV66Pc7oU70grZ0UD0pW82pqUHTTqYAkVf7Zf4H-YE36DOvrmbYhEe6-0GNEyKd1wH3f4evyMjqh81QqGRZFr2rDYCUjmUN5jxgb~mBzHJtW6UI-X3HcGZGMG~BqPR3UZ-kUcSL3AD~G7Z7KrlYnByjzPl3HoogSZptXmXLsvcN7ei2dURxTetOgVXMtOjeJmjWWooaJcUcUx0J~rajKFduCw19YcBJHB8AV8SQ8m61XsWhNZe3QA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Periostin_regulates_collagen_fibrillogenesis_and_the_biomechanical_properties_of_connective_tissues","translated_slug":"","page_count":25,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":86535526,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86535526/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/86535526/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Periostin_regulates_collagen_fibrillogen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86535526/ptpmcrender-libre.pdf?1653629819=\u0026response-content-disposition=attachment%3B+filename%3DPeriostin_regulates_collagen_fibrillogen.pdf\u0026Expires=1732499583\u0026Signature=I6YI8XYiuGrUBsuXtU4rv1C4PrE1YUOjhWa93Wnvhk-LJfEcWlMzQfYWMMFW4lw0OymX1RIHCZN8zlwP~tC~Vs-ijMySNqfptKV66Pc7oU70grZ0UD0pW82pqUHTTqYAkVf7Zf4H-YE36DOvrmbYhEe6-0GNEyKd1wH3f4evyMjqh81QqGRZFr2rDYCUjmUN5jxgb~mBzHJtW6UI-X3HcGZGMG~BqPR3UZ-kUcSL3AD~G7Z7KrlYnByjzPl3HoogSZptXmXLsvcN7ei2dURxTetOgVXMtOjeJmjWWooaJcUcUx0J~rajKFduCw19YcBJHB8AV8SQ8m61XsWhNZe3QA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":29149,"name":"Extracellular Matrix","url":"https://www.academia.edu/Documents/in/Extracellular_Matrix"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":60915,"name":"Cellular","url":"https://www.academia.edu/Documents/in/Cellular"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":78753,"name":"Differential scanning calorimetry","url":"https://www.academia.edu/Documents/in/Differential_scanning_calorimetry"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":129474,"name":"Connective tissue","url":"https://www.academia.edu/Documents/in/Connective_tissue"},{"id":216699,"name":"Immunoprecipitation","url":"https://www.academia.edu/Documents/in/Immunoprecipitation"},{"id":402759,"name":"Chickens","url":"https://www.academia.edu/Documents/in/Chickens"},{"id":851448,"name":"Fibrillogenesis","url":"https://www.academia.edu/Documents/in/Fibrillogenesis"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":1824499,"name":"Cell Adhesion Molecules","url":"https://www.academia.edu/Documents/in/Cell_Adhesion_Molecules"},{"id":1902100,"name":"Biomechanical Phenomena","url":"https://www.academia.edu/Documents/in/Biomechanical_Phenomena"},{"id":3675689,"name":"Chick embryo","url":"https://www.academia.edu/Documents/in/Chick_embryo"},{"id":4045206,"name":"Collagen type I","url":"https://www.academia.edu/Documents/in/Collagen_type_I"}],"urls":[{"id":20814595,"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjcb.21224"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="80012393"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/80012393/Periostin_regulates_collagen_fibrillogenesis_and_the_biomechanical_properties_of_connective_tissues"><img alt="Research paper thumbnail of Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues" class="work-thumbnail" src="https://attachments.academia-assets.com/86535527/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/80012393/Periostin_regulates_collagen_fibrillogenesis_and_the_biomechanical_properties_of_connective_tissues">Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues</a></div><div class="wp-workCard_item"><span>Journal of Cellular Biochemistry</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9118e2d4a0a35d1c673f9aae7d9bb856" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86535527,"asset_id":80012393,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86535527/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="80012393"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="80012393"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80012393; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=80012393]").text(description); $(".js-view-count[data-work-id=80012393]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 80012393; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='80012393']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 80012393, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9118e2d4a0a35d1c673f9aae7d9bb856" } } $('.js-work-strip[data-work-id=80012393]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":80012393,"title":"Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues","translated_title":"","metadata":{"publisher":"Wiley","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Journal of Cellular Biochemistry"},"translated_abstract":null,"internal_url":"https://www.academia.edu/80012393/Periostin_regulates_collagen_fibrillogenesis_and_the_biomechanical_properties_of_connective_tissues","translated_internal_url":"","created_at":"2022-05-26T22:27:19.881-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":86535527,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86535527/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/86535527/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Periostin_regulates_collagen_fibrillogen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86535527/ptpmcrender-libre.pdf?1653629819=\u0026response-content-disposition=attachment%3B+filename%3DPeriostin_regulates_collagen_fibrillogen.pdf\u0026Expires=1732499583\u0026Signature=clJZoFG7aEQ2QQPcVZ8IPRQ7Knumeqapn6wUAUQT8dnp5a5ebr1tAk9z-WyKiAuUDoL3VbGgee6~AiQ9Bs3cUeRYnTkR61RZrhMr4mQEz5AAM9LKvw0WoSoN69W2uQZQE0v0EA~pE9LUgPXTJaIntCUqy6dM5mn~7eJKJ-mnw9uFq-pS-~4~2v0KnzWRvLDjkaVz92jyyrGFJwWdAUAg8TohOhE7lPBpcG0bgC3JkECbJtlOkjLIor9N-ipXBo75Gr4sj3-zwOwn6fdkiAxZP2XvtP-JUvtmahxopHJxZWHmdA5OreOURTio4086Lf~kx1DVhAppwKH6YPIFzkrO0Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Periostin_regulates_collagen_fibrillogenesis_and_the_biomechanical_properties_of_connective_tissues","translated_slug":"","page_count":25,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":86535527,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86535527/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/86535527/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Periostin_regulates_collagen_fibrillogen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86535527/ptpmcrender-libre.pdf?1653629819=\u0026response-content-disposition=attachment%3B+filename%3DPeriostin_regulates_collagen_fibrillogen.pdf\u0026Expires=1732499583\u0026Signature=clJZoFG7aEQ2QQPcVZ8IPRQ7Knumeqapn6wUAUQT8dnp5a5ebr1tAk9z-WyKiAuUDoL3VbGgee6~AiQ9Bs3cUeRYnTkR61RZrhMr4mQEz5AAM9LKvw0WoSoN69W2uQZQE0v0EA~pE9LUgPXTJaIntCUqy6dM5mn~7eJKJ-mnw9uFq-pS-~4~2v0KnzWRvLDjkaVz92jyyrGFJwWdAUAg8TohOhE7lPBpcG0bgC3JkECbJtlOkjLIor9N-ipXBo75Gr4sj3-zwOwn6fdkiAxZP2XvtP-JUvtmahxopHJxZWHmdA5OreOURTio4086Lf~kx1DVhAppwKH6YPIFzkrO0Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":29149,"name":"Extracellular Matrix","url":"https://www.academia.edu/Documents/in/Extracellular_Matrix"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":60915,"name":"Cellular","url":"https://www.academia.edu/Documents/in/Cellular"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":78753,"name":"Differential scanning calorimetry","url":"https://www.academia.edu/Documents/in/Differential_scanning_calorimetry"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":129474,"name":"Connective tissue","url":"https://www.academia.edu/Documents/in/Connective_tissue"},{"id":216699,"name":"Immunoprecipitation","url":"https://www.academia.edu/Documents/in/Immunoprecipitation"},{"id":402759,"name":"Chickens","url":"https://www.academia.edu/Documents/in/Chickens"},{"id":851448,"name":"Fibrillogenesis","url":"https://www.academia.edu/Documents/in/Fibrillogenesis"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":1824499,"name":"Cell Adhesion Molecules","url":"https://www.academia.edu/Documents/in/Cell_Adhesion_Molecules"},{"id":1902100,"name":"Biomechanical Phenomena","url":"https://www.academia.edu/Documents/in/Biomechanical_Phenomena"},{"id":3675689,"name":"Chick embryo","url":"https://www.academia.edu/Documents/in/Chick_embryo"},{"id":4045206,"name":"Collagen type I","url":"https://www.academia.edu/Documents/in/Collagen_type_I"}],"urls":[{"id":20814593,"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjcb.21224"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="4005540" id="papers"><div class="js-work-strip profile--work_container" data-work-id="101949852"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/101949852/Viability_of_Bioprinted_Cellular_Constructs_Using_a_Three_Dispenser_Cartesian_Printer"><img alt="Research paper thumbnail of Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer" class="work-thumbnail" src="https://attachments.academia-assets.com/102347670/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/101949852/Viability_of_Bioprinted_Cellular_Constructs_Using_a_Three_Dispenser_Cartesian_Printer">Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer</a></div><div class="wp-workCard_item"><span>Journal of Visualized Experiments</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8f02940292bbdb7ee3aa9b6f20815226" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102347670,"asset_id":101949852,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102347670/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="101949852"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="101949852"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 101949852; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=101949852]").text(description); $(".js-view-count[data-work-id=101949852]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 101949852; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='101949852']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 101949852, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8f02940292bbdb7ee3aa9b6f20815226" } } $('.js-work-strip[data-work-id=101949852]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":101949852,"title":"Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer","translated_title":"","metadata":{"publisher":"MyJove Corporation","publication_name":"Journal of Visualized Experiments"},"translated_abstract":null,"internal_url":"https://www.academia.edu/101949852/Viability_of_Bioprinted_Cellular_Constructs_Using_a_Three_Dispenser_Cartesian_Printer","translated_internal_url":"","created_at":"2023-05-17T19:27:48.942-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":102347670,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102347670/thumbnails/1.jpg","file_name":"jove-materials-53156-viability-bioprinted-cellular-constructs-using-three-dispenser.pdf","download_url":"https://www.academia.edu/attachments/102347670/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Viability_of_Bioprinted_Cellular_Constru.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102347670/jove-materials-53156-viability-bioprinted-cellular-constructs-using-three-dispenser-libre.pdf?1684378955=\u0026response-content-disposition=attachment%3B+filename%3DViability_of_Bioprinted_Cellular_Constru.pdf\u0026Expires=1732499581\u0026Signature=FoEcG-Qbp24X9nTmdZhoQ5W6oKkrnGiRg7T0N4cQces8y0V3mUNSD-oSGAif8jex0jLprd5CPwL0pxbzJ8rgnENgCrXECdimIdTsv2B24DG5~Pvdv4u1kebrzej2tDAE6O4Dj-ru9If76sYLc22OAgmKifqtr4s8wAKKsbeMgcMV98ZfdKcOLsAnoGvxfsB2LRCfIkG-7OWzA2DCV28CkET-RhKbYSdup0O8DNUw0Zy5LEDkx6krrLRWUABdoqHGpXq4iJ0oxnUGfser5W7b7tsIMXT4KqvyJG-l9YtKSo7orkvugZfF8L9f8x639TjFlW3V1o0CvHsoSrTe-wjp0w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Viability_of_Bioprinted_Cellular_Constructs_Using_a_Three_Dispenser_Cartesian_Printer","translated_slug":"","page_count":2,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":102347670,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102347670/thumbnails/1.jpg","file_name":"jove-materials-53156-viability-bioprinted-cellular-constructs-using-three-dispenser.pdf","download_url":"https://www.academia.edu/attachments/102347670/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Viability_of_Bioprinted_Cellular_Constru.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102347670/jove-materials-53156-viability-bioprinted-cellular-constructs-using-three-dispenser-libre.pdf?1684378955=\u0026response-content-disposition=attachment%3B+filename%3DViability_of_Bioprinted_Cellular_Constru.pdf\u0026Expires=1732499581\u0026Signature=FoEcG-Qbp24X9nTmdZhoQ5W6oKkrnGiRg7T0N4cQces8y0V3mUNSD-oSGAif8jex0jLprd5CPwL0pxbzJ8rgnENgCrXECdimIdTsv2B24DG5~Pvdv4u1kebrzej2tDAE6O4Dj-ru9If76sYLc22OAgmKifqtr4s8wAKKsbeMgcMV98ZfdKcOLsAnoGvxfsB2LRCfIkG-7OWzA2DCV28CkET-RhKbYSdup0O8DNUw0Zy5LEDkx6krrLRWUABdoqHGpXq4iJ0oxnUGfser5W7b7tsIMXT4KqvyJG-l9YtKSo7orkvugZfF8L9f8x639TjFlW3V1o0CvHsoSrTe-wjp0w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":422,"name":"Computer Science","url":"https://www.academia.edu/Documents/in/Computer_Science"},{"id":2699,"name":"Tissue Engineering","url":"https://www.academia.edu/Documents/in/Tissue_Engineering"},{"id":5467,"name":"Biomimetics","url":"https://www.academia.edu/Documents/in/Biomimetics"},{"id":6160,"name":"Computer Aided Design","url":"https://www.academia.edu/Documents/in/Computer_Aided_Design"},{"id":22442,"name":"Hydrogels","url":"https://www.academia.edu/Documents/in/Hydrogels"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":29149,"name":"Extracellular Matrix","url":"https://www.academia.edu/Documents/in/Extracellular_Matrix"},{"id":53293,"name":"Software","url":"https://www.academia.edu/Documents/in/Software"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":136801,"name":"Fabrication","url":"https://www.academia.edu/Documents/in/Fabrication"},{"id":387484,"name":"Alginates","url":"https://www.academia.edu/Documents/in/Alginates"},{"id":472784,"name":"Adipocytes","url":"https://www.academia.edu/Documents/in/Adipocytes"},{"id":477968,"name":"Stromal Cells","url":"https://www.academia.edu/Documents/in/Stromal_Cells"},{"id":785710,"name":"Bioprinting","url":"https://www.academia.edu/Documents/in/Bioprinting"},{"id":2049894,"name":"3-D bioprinting","url":"https://www.academia.edu/Documents/in/3-D_bioprinting"},{"id":3873187,"name":"Tissue Scaffolds","url":"https://www.academia.edu/Documents/in/Tissue_Scaffolds"}],"urls":[{"id":31533695,"url":"https://www.jove.com/v/53156/viability-bioprinted-cellular-constructs-using-three-dispenser"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96423325"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96423325/Accepted_by"><img alt="Research paper thumbnail of Accepted by" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96423325/Accepted_by">Accepted by</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">iii To precisely control the position of multiple cell types in a culture for the study of cell-c...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">iii To precisely control the position of multiple cell types in a culture for the study of cell-cell contact interactions, we have developed a laser micropatterning technique. The technique employs the optical forces of a weakly focused laser beam. In the beam’s focal region, the optical force draws microparticles, such as cells, into the center of the beam, propels them along the beam axis, and guides them onto a target surface. Specific patterns are created through computer-controlled micromanipulation of the substrate relative to the laser. In this thesis, we systematically vary the controllable laser parameters, namely, wavelength, intensity, and exposure time of the laser on single cells to clearly establish laser parameters that allow negligible cell damage with significant cellular position control. To accomplish this goal, embryonic day 7 (E7) chick forebrains neurons were cultured with control and test cells selected one hour after seeding to allow attachment, at which time...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96423325"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96423325"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96423325; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96423325]").text(description); $(".js-view-count[data-work-id=96423325]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96423325; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96423325']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96423325, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=96423325]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96423325,"title":"Accepted by","translated_title":"","metadata":{"abstract":"iii To precisely control the position of multiple cell types in a culture for the study of cell-cell contact interactions, we have developed a laser micropatterning technique. The technique employs the optical forces of a weakly focused laser beam. In the beam’s focal region, the optical force draws microparticles, such as cells, into the center of the beam, propels them along the beam axis, and guides them onto a target surface. Specific patterns are created through computer-controlled micromanipulation of the substrate relative to the laser. In this thesis, we systematically vary the controllable laser parameters, namely, wavelength, intensity, and exposure time of the laser on single cells to clearly establish laser parameters that allow negligible cell damage with significant cellular position control. To accomplish this goal, embryonic day 7 (E7) chick forebrains neurons were cultured with control and test cells selected one hour after seeding to allow attachment, at which time...","publication_date":{"day":null,"month":null,"year":2007,"errors":{}}},"translated_abstract":"iii To precisely control the position of multiple cell types in a culture for the study of cell-cell contact interactions, we have developed a laser micropatterning technique. The technique employs the optical forces of a weakly focused laser beam. In the beam’s focal region, the optical force draws microparticles, such as cells, into the center of the beam, propels them along the beam axis, and guides them onto a target surface. Specific patterns are created through computer-controlled micromanipulation of the substrate relative to the laser. In this thesis, we systematically vary the controllable laser parameters, namely, wavelength, intensity, and exposure time of the laser on single cells to clearly establish laser parameters that allow negligible cell damage with significant cellular position control. To accomplish this goal, embryonic day 7 (E7) chick forebrains neurons were cultured with control and test cells selected one hour after seeding to allow attachment, at which time...","internal_url":"https://www.academia.edu/96423325/Accepted_by","translated_internal_url":"","created_at":"2023-02-06T11:00:17.407-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Accepted_by","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[],"research_interests":[],"urls":[{"id":28745539,"url":"http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1031.7751\u0026rep=rep1\u0026type=pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="91173970"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/91173970/FOLFOX_Therapy_Induces_Feedback_Upregulation_of_CD44v6_through_YB_1_to_Maintain_Stemness_in_Colon_Initiating_Cells"><img alt="Research paper thumbnail of FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating Cells" class="work-thumbnail" src="https://attachments.academia-assets.com/94535862/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/91173970/FOLFOX_Therapy_Induces_Feedback_Upregulation_of_CD44v6_through_YB_1_to_Maintain_Stemness_in_Colon_Initiating_Cells">FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating Cells</a></div><div class="wp-workCard_item"><span>International Journal of Molecular Sciences</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cancer initiating cells (CICs) drive tumor formation and drug-resistance, but how they develop dr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cancer initiating cells (CICs) drive tumor formation and drug-resistance, but how they develop drug-resistance characteristics is not well understood. In this study, we demonstrate that chemotherapeutic agent FOLFOX, commonly used for drug-resistant/metastatic colorectal cancer (CRC) treatment, induces overexpression of CD44v6, MDR1, and oncogenic transcription/translation factor Y-box-binding protein-1 (YB-1). Our study revealed that CD44v6, a receptor for hyaluronan, increased the YB-1 expression through PGE2/EP1-mTOR pathway. Deleting CD44v6, and YB-1 by the CRISPR/Cas9 system attenuates the in vitro and in vivo tumor growth of CICs from FOLFOX resistant cells. The results of DNA:CD44v6 immunoprecipitated complexes by ChIP (chromatin-immunoprecipitation) assay showed that CD44v6 maintained the stemness traits by promoting several antiapoptotic and stemness genes, including cyclin-D1,BCL2,FZD1,GINS-1, and MMP9. Further, computer-based analysis of the clones obtained from the DNA:C...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="012f15f427746aeee06fe4c67b3347f4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94535862,"asset_id":91173970,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94535862/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="91173970"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="91173970"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 91173970; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=91173970]").text(description); $(".js-view-count[data-work-id=91173970]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 91173970; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='91173970']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 91173970, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "012f15f427746aeee06fe4c67b3347f4" } } $('.js-work-strip[data-work-id=91173970]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":91173970,"title":"FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating Cells","translated_title":"","metadata":{"abstract":"Cancer initiating cells (CICs) drive tumor formation and drug-resistance, but how they develop drug-resistance characteristics is not well understood. In this study, we demonstrate that chemotherapeutic agent FOLFOX, commonly used for drug-resistant/metastatic colorectal cancer (CRC) treatment, induces overexpression of CD44v6, MDR1, and oncogenic transcription/translation factor Y-box-binding protein-1 (YB-1). Our study revealed that CD44v6, a receptor for hyaluronan, increased the YB-1 expression through PGE2/EP1-mTOR pathway. Deleting CD44v6, and YB-1 by the CRISPR/Cas9 system attenuates the in vitro and in vivo tumor growth of CICs from FOLFOX resistant cells. The results of DNA:CD44v6 immunoprecipitated complexes by ChIP (chromatin-immunoprecipitation) assay showed that CD44v6 maintained the stemness traits by promoting several antiapoptotic and stemness genes, including cyclin-D1,BCL2,FZD1,GINS-1, and MMP9. Further, computer-based analysis of the clones obtained from the DNA:C...","publisher":"MDPI AG","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"International Journal of Molecular Sciences"},"translated_abstract":"Cancer initiating cells (CICs) drive tumor formation and drug-resistance, but how they develop drug-resistance characteristics is not well understood. In this study, we demonstrate that chemotherapeutic agent FOLFOX, commonly used for drug-resistant/metastatic colorectal cancer (CRC) treatment, induces overexpression of CD44v6, MDR1, and oncogenic transcription/translation factor Y-box-binding protein-1 (YB-1). Our study revealed that CD44v6, a receptor for hyaluronan, increased the YB-1 expression through PGE2/EP1-mTOR pathway. Deleting CD44v6, and YB-1 by the CRISPR/Cas9 system attenuates the in vitro and in vivo tumor growth of CICs from FOLFOX resistant cells. The results of DNA:CD44v6 immunoprecipitated complexes by ChIP (chromatin-immunoprecipitation) assay showed that CD44v6 maintained the stemness traits by promoting several antiapoptotic and stemness genes, including cyclin-D1,BCL2,FZD1,GINS-1, and MMP9. Further, computer-based analysis of the clones obtained from the DNA:C...","internal_url":"https://www.academia.edu/91173970/FOLFOX_Therapy_Induces_Feedback_Upregulation_of_CD44v6_through_YB_1_to_Maintain_Stemness_in_Colon_Initiating_Cells","translated_internal_url":"","created_at":"2022-11-19T22:04:22.539-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94535862,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94535862/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/94535862/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"FOLFOX_Therapy_Induces_Feedback_Upregula.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94535862/pdf-libre.pdf?1668928323=\u0026response-content-disposition=attachment%3B+filename%3DFOLFOX_Therapy_Induces_Feedback_Upregula.pdf\u0026Expires=1732499582\u0026Signature=ClPGq43eYMeg6lfah1JjLbKt8xCBXEMfqeKIjB3y9J7oN3t3dLuK3S1XkAocWN~IxVzgFdgBxBSlqknutJZMq9LG3NbTeU~ANTBepCBonQNnfHtEFoHve6UVZQQWFQt176Cp7Pnq9J2aPGx5ZxVN4iLcbLIcOaUtnK8~QzfuA4W1cWVHqd74eG19snMWSgIXF1npXP~NFUYUn2bsrNJvkK~DsNA75F5rrdReGTx8B0MQnZpBIBAth6xtwj8Q6omjuaJ9pTDwBILB21Fk-pncZvoPCM8bGGgF0lTC69XP0gwW9yXpx8HU0SdCi8Mv86kMOXv9E448UmeLdAzhQFAvTw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"FOLFOX_Therapy_Induces_Feedback_Upregulation_of_CD44v6_through_YB_1_to_Maintain_Stemness_in_Colon_Initiating_Cells","translated_slug":"","page_count":37,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":94535862,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94535862/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/94535862/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"FOLFOX_Therapy_Induces_Feedback_Upregula.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94535862/pdf-libre.pdf?1668928323=\u0026response-content-disposition=attachment%3B+filename%3DFOLFOX_Therapy_Induces_Feedback_Upregula.pdf\u0026Expires=1732499582\u0026Signature=ClPGq43eYMeg6lfah1JjLbKt8xCBXEMfqeKIjB3y9J7oN3t3dLuK3S1XkAocWN~IxVzgFdgBxBSlqknutJZMq9LG3NbTeU~ANTBepCBonQNnfHtEFoHve6UVZQQWFQt176Cp7Pnq9J2aPGx5ZxVN4iLcbLIcOaUtnK8~QzfuA4W1cWVHqd74eG19snMWSgIXF1npXP~NFUYUn2bsrNJvkK~DsNA75F5rrdReGTx8B0MQnZpBIBAth6xtwj8Q6omjuaJ9pTDwBILB21Fk-pncZvoPCM8bGGgF0lTC69XP0gwW9yXpx8HU0SdCi8Mv86kMOXv9E448UmeLdAzhQFAvTw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":94535863,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94535863/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/94535863/download_file","bulk_download_file_name":"FOLFOX_Therapy_Induces_Feedback_Upregula.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94535863/pdf-libre.pdf?1668928335=\u0026response-content-disposition=attachment%3B+filename%3DFOLFOX_Therapy_Induces_Feedback_Upregula.pdf\u0026Expires=1732499582\u0026Signature=H8v61Y50vWevCVPpbV8F2NDsHM1kl8f8vBCJeCMsV5KCf5UFTgmxl8IRx2vYXE4cYVn0OYYu-z2RltdZ-wheO46MMkoBWZlRdeE5SGgMdd17mSWHqfuUXv5iLArAYdLyLfyInKRRdFL8Z0fa3GJzOKhNL2SJ~V8GVxbec2xfsjYRbZAreAxeYInwMeA6Ic7uhPsurLr~kO8fWJxZHdrqVWFjn0cXxppriwXVhpyt0npMA2biXFG~EsZPaOB~kMIEpUJ-n-NDhwPs8Mwzb9BJY6RQCXLSja0yZb0zoc3sSqpB7yozEjxO7aPmHdSAe4dma53MfNS1oY7SaDtaBP~Dpg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":37292,"name":"Colorectal cancer","url":"https://www.academia.edu/Documents/in/Colorectal_cancer"},{"id":216943,"name":"CD","url":"https://www.academia.edu/Documents/in/CD"},{"id":275658,"name":"Cancer Stem Cell","url":"https://www.academia.edu/Documents/in/Cancer_Stem_Cell"},{"id":276821,"name":"Molecular sciences","url":"https://www.academia.edu/Documents/in/Molecular_sciences"},{"id":440820,"name":"Chromatin Immunoprecipitation","url":"https://www.academia.edu/Documents/in/Chromatin_Immunoprecipitation"}],"urls":[{"id":26174390,"url":"https://www.mdpi.com/1422-0067/22/2/753/pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528495"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528495/Scalable_robotic_biofabrication_of_tissue_spheroids"><img alt="Research paper thumbnail of Scalable robotic biofabrication of tissue spheroids" class="work-thumbnail" src="https://attachments.academia-assets.com/90200533/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528495/Scalable_robotic_biofabrication_of_tissue_spheroids">Scalable robotic biofabrication of tissue spheroids</a></div><div class="wp-workCard_item"><span>Biofabrication</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bcf32a167ecb1718091e41c0be63925e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200533,"asset_id":85528495,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200533/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528495"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528495"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528495; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528495]").text(description); $(".js-view-count[data-work-id=85528495]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528495; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528495']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528495, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "bcf32a167ecb1718091e41c0be63925e" } } $('.js-work-strip[data-work-id=85528495]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528495,"title":"Scalable robotic biofabrication of tissue spheroids","translated_title":"","metadata":{"publisher":"IOP Publishing","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Biofabrication"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528495/Scalable_robotic_biofabrication_of_tissue_spheroids","translated_internal_url":"","created_at":"2022-08-24T07:48:08.555-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200533,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200533/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200533/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Scalable_robotic_biofabrication_of_tissu.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200533/ptpmcrender-libre.pdf?1661355231=\u0026response-content-disposition=attachment%3B+filename%3DScalable_robotic_biofabrication_of_tissu.pdf\u0026Expires=1732499582\u0026Signature=b65R4ULB-2jcwttwW~iMHzHdODCMcmwJRibUGdRqcFgmX8khBWgGgBjyxks5eErWpFfoSAeC-n40MR3u~eczI3RdOnSeKX5mebR5uB8Iene4gMhHo1NlCV5oweE~O0Crwfo4vMnJBCjLHCQMMo5qbK9xPbJTa9dl8BZtnBWUi87Zla28L1MxwbiN2MpdGxOKIyriBLp5NUKgXSvIbf04o6Sg58RRfpO~sxvkF3Lte8QY7fTe5PjFRl7hSflrZCh-JILsStpLPG4QdrA590hfim0ktZF9sLFUuixXKX~eWRlaUqmPnQpPwnV6W2qN704SkIzbOqKaIRgvLeebi-N8JA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Scalable_robotic_biofabrication_of_tissue_spheroids","translated_slug":"","page_count":16,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200533,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200533/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200533/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Scalable_robotic_biofabrication_of_tissu.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200533/ptpmcrender-libre.pdf?1661355231=\u0026response-content-disposition=attachment%3B+filename%3DScalable_robotic_biofabrication_of_tissu.pdf\u0026Expires=1732499582\u0026Signature=b65R4ULB-2jcwttwW~iMHzHdODCMcmwJRibUGdRqcFgmX8khBWgGgBjyxks5eErWpFfoSAeC-n40MR3u~eczI3RdOnSeKX5mebR5uB8Iene4gMhHo1NlCV5oweE~O0Crwfo4vMnJBCjLHCQMMo5qbK9xPbJTa9dl8BZtnBWUi87Zla28L1MxwbiN2MpdGxOKIyriBLp5NUKgXSvIbf04o6Sg58RRfpO~sxvkF3Lte8QY7fTe5PjFRl7hSflrZCh-JILsStpLPG4QdrA590hfim0ktZF9sLFUuixXKX~eWRlaUqmPnQpPwnV6W2qN704SkIzbOqKaIRgvLeebi-N8JA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":511,"name":"Materials Science","url":"https://www.academia.edu/Documents/in/Materials_Science"},{"id":2699,"name":"Tissue Engineering","url":"https://www.academia.edu/Documents/in/Tissue_Engineering"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52489,"name":"Adipose tissue","url":"https://www.academia.edu/Documents/in/Adipose_tissue"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":66379,"name":"Automation","url":"https://www.academia.edu/Documents/in/Automation"},{"id":216119,"name":"Biofabrication","url":"https://www.academia.edu/Documents/in/Biofabrication"},{"id":401634,"name":"Additive Manufaturing","url":"https://www.academia.edu/Documents/in/Additive_Manufaturing"},{"id":1877951,"name":"Cell Size","url":"https://www.academia.edu/Documents/in/Cell_Size"},{"id":4121555,"name":"Cell culture techniques","url":"https://www.academia.edu/Documents/in/Cell_culture_techniques"}],"urls":[{"id":23312394,"url":"https://iopscience.iop.org/article/10.1088/1758-5082/3/2/025002/pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528494"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528494/Tissue_engineering_of_heart_valve_leaflet_by_self_assembly_of_tissue_spheroids_biofabricated_from_human_fat_tissue_derived_stem_cells"><img alt="Research paper thumbnail of Tissue engineering of heart valve leaflet by self-assembly of tissue spheroids biofabricated from human fat tissue derived stem cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528494/Tissue_engineering_of_heart_valve_leaflet_by_self_assembly_of_tissue_spheroids_biofabricated_from_human_fat_tissue_derived_stem_cells">Tissue engineering of heart valve leaflet by self-assembly of tissue spheroids biofabricated from human fat tissue derived stem cells</a></div><div class="wp-workCard_item"><span>IFMBE Proceedings</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Bioengineering of living heart valve substitute suitable for implantation into pediatric patients...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bioengineering of living heart valve substitute suitable for implantation into pediatric patients with heart valve diseases is an unsolved challenge in cardiovascular tissue engineering. In order to identify desirable material properties of such construct, the biomechanical, histological, histochemical and biochemical properties of fetal, perinatal and adult porcine heart valve leaflets have been systematically investigated. It have been shown that increasing</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528494"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528494"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528494; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528494]").text(description); $(".js-view-count[data-work-id=85528494]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528494; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528494']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528494, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85528494]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528494,"title":"Tissue engineering of heart valve leaflet by self-assembly of tissue spheroids biofabricated from human fat tissue derived stem cells","translated_title":"","metadata":{"abstract":"Bioengineering of living heart valve substitute suitable for implantation into pediatric patients with heart valve diseases is an unsolved challenge in cardiovascular tissue engineering. In order to identify desirable material properties of such construct, the biomechanical, histological, histochemical and biochemical properties of fetal, perinatal and adult porcine heart valve leaflets have been systematically investigated. It have been shown that increasing","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"IFMBE Proceedings"},"translated_abstract":"Bioengineering of living heart valve substitute suitable for implantation into pediatric patients with heart valve diseases is an unsolved challenge in cardiovascular tissue engineering. In order to identify desirable material properties of such construct, the biomechanical, histological, histochemical and biochemical properties of fetal, perinatal and adult porcine heart valve leaflets have been systematically investigated. It have been shown that increasing","internal_url":"https://www.academia.edu/85528494/Tissue_engineering_of_heart_valve_leaflet_by_self_assembly_of_tissue_spheroids_biofabricated_from_human_fat_tissue_derived_stem_cells","translated_internal_url":"","created_at":"2022-08-24T07:48:08.408-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Tissue_engineering_of_heart_valve_leaflet_by_self_assembly_of_tissue_spheroids_biofabricated_from_human_fat_tissue_derived_stem_cells","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":2699,"name":"Tissue Engineering","url":"https://www.academia.edu/Documents/in/Tissue_Engineering"},{"id":3642,"name":"Stem Cells","url":"https://www.academia.edu/Documents/in/Stem_Cells"},{"id":11073,"name":"Self Assembly","url":"https://www.academia.edu/Documents/in/Self_Assembly"},{"id":23163,"name":"Stem Cell","url":"https://www.academia.edu/Documents/in/Stem_Cell"},{"id":52489,"name":"Adipose tissue","url":"https://www.academia.edu/Documents/in/Adipose_tissue"},{"id":1001094,"name":"Material Properties","url":"https://www.academia.edu/Documents/in/Material_Properties"},{"id":1311840,"name":"Heart Valve","url":"https://www.academia.edu/Documents/in/Heart_Valve"},{"id":2724508,"name":"Mechanical Property","url":"https://www.academia.edu/Documents/in/Mechanical_Property"},{"id":3275513,"name":"Heart valve disease","url":"https://www.academia.edu/Documents/in/Heart_valve_disease"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528493"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528493/Engineering_alginate_as_bioink_for_bioprinting"><img alt="Research paper thumbnail of Engineering alginate as bioink for bioprinting" class="work-thumbnail" src="https://attachments.academia-assets.com/90200537/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528493/Engineering_alginate_as_bioink_for_bioprinting">Engineering alginate as bioink for bioprinting</a></div><div class="wp-workCard_item"><span>Acta biomaterialia</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Recent advances in three-dimensional (3-D) printing offer an excellent opportunity to address cri...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Recent advances in three-dimensional (3-D) printing offer an excellent opportunity to address critical challenges faced by current tissue engineering approaches. Alginate hydrogels have been used extensively as bioinks for 3-D bioprinting. However, most previous research has focused on native alginates with limited degradation. The application of oxidized alginates with controlled degradation in bioprinting has not been explored. Here, a collection of 30 different alginate hydrogels with varied oxidation percentages and concentrations was prepared to develop a bioink platform that can be applied to a multitude of tissue engineering applications. The authors systematically investigated the effects of two key material properties (i.e. viscosity and density) of alginate solutions on their printabilities to identify a suitable range of material properties of alginates to be applied to bioprinting. Further, four alginate solutions with varied biodegradability were printed with human adip...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="96dfe6ca3357790ae89a5e07a5afe644" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200537,"asset_id":85528493,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200537/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528493"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528493"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528493; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528493]").text(description); $(".js-view-count[data-work-id=85528493]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528493; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528493']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528493, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "96dfe6ca3357790ae89a5e07a5afe644" } } $('.js-work-strip[data-work-id=85528493]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528493,"title":"Engineering alginate as bioink for bioprinting","translated_title":"","metadata":{"abstract":"Recent advances in three-dimensional (3-D) printing offer an excellent opportunity to address critical challenges faced by current tissue engineering approaches. Alginate hydrogels have been used extensively as bioinks for 3-D bioprinting. However, most previous research has focused on native alginates with limited degradation. The application of oxidized alginates with controlled degradation in bioprinting has not been explored. Here, a collection of 30 different alginate hydrogels with varied oxidation percentages and concentrations was prepared to develop a bioink platform that can be applied to a multitude of tissue engineering applications. The authors systematically investigated the effects of two key material properties (i.e. viscosity and density) of alginate solutions on their printabilities to identify a suitable range of material properties of alginates to be applied to bioprinting. Further, four alginate solutions with varied biodegradability were printed with human adip...","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Acta biomaterialia"},"translated_abstract":"Recent advances in three-dimensional (3-D) printing offer an excellent opportunity to address critical challenges faced by current tissue engineering approaches. Alginate hydrogels have been used extensively as bioinks for 3-D bioprinting. However, most previous research has focused on native alginates with limited degradation. The application of oxidized alginates with controlled degradation in bioprinting has not been explored. Here, a collection of 30 different alginate hydrogels with varied oxidation percentages and concentrations was prepared to develop a bioink platform that can be applied to a multitude of tissue engineering applications. The authors systematically investigated the effects of two key material properties (i.e. viscosity and density) of alginate solutions on their printabilities to identify a suitable range of material properties of alginates to be applied to bioprinting. Further, four alginate solutions with varied biodegradability were printed with human adip...","internal_url":"https://www.academia.edu/85528493/Engineering_alginate_as_bioink_for_bioprinting","translated_internal_url":"","created_at":"2022-08-24T07:48:08.290-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200537,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200537/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200537/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Engineering_alginate_as_bioink_for_biopr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200537/ptpmcrender-libre.pdf?1661355226=\u0026response-content-disposition=attachment%3B+filename%3DEngineering_alginate_as_bioink_for_biopr.pdf\u0026Expires=1732499582\u0026Signature=A7tilo5U9npIVBjuHelGv0kfh2exVcnXkTrNBVUgWEgEI~rjl3BxE3Jhk9T8fiU4m3DtmBAIU5WNYFLq1TOZCmAwyLCkva4ZxPoC8ferql~8cOh5~sKbt9HOQahUAvgmWouppujivSlVGrfWNbCSikHx3ED7H4oS5CCjsytIYcv43aUdS2dsDpr8m5k5-yw-CxKP9GB9SzByWLl5nfLNyN9E9lZyTDBIvpJARLf5e6wFG-p0OxtPQ0GGusl3J-3mcDPqioXbzlnlTCvHBWcqCf6igBCRxunQ7JREEJZLP83Rz1B7pypwFBg~zYMER83Da66UWic4CsRvEaTi80TVeg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Engineering_alginate_as_bioink_for_bioprinting","translated_slug":"","page_count":21,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200537,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200537/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200537/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Engineering_alginate_as_bioink_for_biopr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200537/ptpmcrender-libre.pdf?1661355226=\u0026response-content-disposition=attachment%3B+filename%3DEngineering_alginate_as_bioink_for_biopr.pdf\u0026Expires=1732499582\u0026Signature=A7tilo5U9npIVBjuHelGv0kfh2exVcnXkTrNBVUgWEgEI~rjl3BxE3Jhk9T8fiU4m3DtmBAIU5WNYFLq1TOZCmAwyLCkva4ZxPoC8ferql~8cOh5~sKbt9HOQahUAvgmWouppujivSlVGrfWNbCSikHx3ED7H4oS5CCjsytIYcv43aUdS2dsDpr8m5k5-yw-CxKP9GB9SzByWLl5nfLNyN9E9lZyTDBIvpJARLf5e6wFG-p0OxtPQ0GGusl3J-3mcDPqioXbzlnlTCvHBWcqCf6igBCRxunQ7JREEJZLP83Rz1B7pypwFBg~zYMER83Da66UWic4CsRvEaTi80TVeg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":511,"name":"Materials Science","url":"https://www.academia.edu/Documents/in/Materials_Science"},{"id":2699,"name":"Tissue Engineering","url":"https://www.academia.edu/Documents/in/Tissue_Engineering"},{"id":3642,"name":"Stem Cells","url":"https://www.academia.edu/Documents/in/Stem_Cells"},{"id":22442,"name":"Hydrogels","url":"https://www.academia.edu/Documents/in/Hydrogels"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":52489,"name":"Adipose tissue","url":"https://www.academia.edu/Documents/in/Adipose_tissue"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":216119,"name":"Biofabrication","url":"https://www.academia.edu/Documents/in/Biofabrication"},{"id":224124,"name":"Ink","url":"https://www.academia.edu/Documents/in/Ink"},{"id":387484,"name":"Alginates","url":"https://www.academia.edu/Documents/in/Alginates"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation"},{"id":892969,"name":"Materials Testing","url":"https://www.academia.edu/Documents/in/Materials_Testing"},{"id":1003917,"name":"Three dimensional Printing (3DP)","url":"https://www.academia.edu/Documents/in/Three_dimensional_Printing_3DP_"},{"id":2049894,"name":"3-D bioprinting","url":"https://www.academia.edu/Documents/in/3-D_bioprinting"},{"id":2285371,"name":"D-glucuronic acid","url":"https://www.academia.edu/Documents/in/D-glucuronic_acid"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528492"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528492/Tissue_spheroid_fusion_based_in_vitro_screening_assays_for_analysis_of_tissue_maturation"><img alt="Research paper thumbnail of Tissue spheroid fusion-based in vitro screening assays for analysis of tissue maturation" class="work-thumbnail" src="https://attachments.academia-assets.com/90200534/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528492/Tissue_spheroid_fusion_based_in_vitro_screening_assays_for_analysis_of_tissue_maturation">Tissue spheroid fusion-based in vitro screening assays for analysis of tissue maturation</a></div><div class="wp-workCard_item"><span>Journal of Tissue Engineering and Regenerative Medicine</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a57052fab0d21a1fe07898ef32534f88" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200534,"asset_id":85528492,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200534/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528492"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528492"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528492; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528492]").text(description); $(".js-view-count[data-work-id=85528492]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528492; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528492']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528492, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a57052fab0d21a1fe07898ef32534f88" } } $('.js-work-strip[data-work-id=85528492]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528492,"title":"Tissue spheroid fusion-based in vitro screening assays for analysis of tissue maturation","translated_title":"","metadata":{"publisher":"Wiley","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Journal of Tissue Engineering and Regenerative Medicine"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528492/Tissue_spheroid_fusion_based_in_vitro_screening_assays_for_analysis_of_tissue_maturation","translated_internal_url":"","created_at":"2022-08-24T07:48:08.141-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200534,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200534/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200534/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Tissue_spheroid_fusion_based_in_vitro_sc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200534/ptpmcrender-libre.pdf?1661355227=\u0026response-content-disposition=attachment%3B+filename%3DTissue_spheroid_fusion_based_in_vitro_sc.pdf\u0026Expires=1732499582\u0026Signature=fXIoHxdLAYyySDXB8cja3JrUvYoCj0Zy43Br3KB6O6i4SSym5h5LrnUxTWNEtWJ3Hg~rIT4DobXFaIvuIIUWtJgTAdDP4QzKFJZ2Ay6Wia33T2dvbmd5okScrZyCGhTNNF-2HMu5xwBTOW9s0gcoyrG-aVJtEBb3llNGZqhAfHVawdkxeM~YG577WLBih9bTrv0KCjRDK09iLPOR6yRO0iOwiq21ixZXoe6mrMMlG3qiRTZyvkd4uX~JxpdvAVY7r5lStkk0s275EPfc-IWyWJR5vevPHXJzrou3hPfijDtNhV6WNb-KTEalAKLEM~RMAmp41f7wUslPNkb1gQSYpg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Tissue_spheroid_fusion_based_in_vitro_screening_assays_for_analysis_of_tissue_maturation","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200534,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200534/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200534/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Tissue_spheroid_fusion_based_in_vitro_sc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200534/ptpmcrender-libre.pdf?1661355227=\u0026response-content-disposition=attachment%3B+filename%3DTissue_spheroid_fusion_based_in_vitro_sc.pdf\u0026Expires=1732499582\u0026Signature=fXIoHxdLAYyySDXB8cja3JrUvYoCj0Zy43Br3KB6O6i4SSym5h5LrnUxTWNEtWJ3Hg~rIT4DobXFaIvuIIUWtJgTAdDP4QzKFJZ2Ay6Wia33T2dvbmd5okScrZyCGhTNNF-2HMu5xwBTOW9s0gcoyrG-aVJtEBb3llNGZqhAfHVawdkxeM~YG577WLBih9bTrv0KCjRDK09iLPOR6yRO0iOwiq21ixZXoe6mrMMlG3qiRTZyvkd4uX~JxpdvAVY7r5lStkk0s275EPfc-IWyWJR5vevPHXJzrou3hPfijDtNhV6WNb-KTEalAKLEM~RMAmp41f7wUslPNkb1gQSYpg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering"},{"id":2699,"name":"Tissue Engineering","url":"https://www.academia.edu/Documents/in/Tissue_Engineering"},{"id":18529,"name":"Fluorescent Dyes and Reagents","url":"https://www.academia.edu/Documents/in/Fluorescent_Dyes_and_Reagents"},{"id":59370,"name":"In Vitro","url":"https://www.academia.edu/Documents/in/In_Vitro"},{"id":73614,"name":"Cell fusion","url":"https://www.academia.edu/Documents/in/Cell_fusion"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology"},{"id":199905,"name":"Tissue engineering and regenerative medicine","url":"https://www.academia.edu/Documents/in/Tissue_engineering_and_regenerative_medicine"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":459613,"name":"Dermis","url":"https://www.academia.edu/Documents/in/Dermis"},{"id":954995,"name":"Human Fibroblasts","url":"https://www.academia.edu/Documents/in/Human_Fibroblasts"},{"id":1824499,"name":"Cell Adhesion Molecules","url":"https://www.academia.edu/Documents/in/Cell_Adhesion_Molecules"},{"id":2533047,"name":"fibroblasts","url":"https://www.academia.edu/Documents/in/fibroblasts"},{"id":3276666,"name":"fluorescent dyes","url":"https://www.academia.edu/Documents/in/fluorescent_dyes"}],"urls":[{"id":23312393,"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fterm.291"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528491"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528491/Inhibition_of_Cardiac_Fibrosis_Mediated_by_Non_Myocyte_Proliferation_in_Hypertrophic_Cardiomyopathy"><img alt="Research paper thumbnail of Inhibition of Cardiac Fibrosis Mediated by Non-Myocyte Proliferation in Hypertrophic Cardiomyopathy" class="work-thumbnail" src="https://attachments.academia-assets.com/90200551/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528491/Inhibition_of_Cardiac_Fibrosis_Mediated_by_Non_Myocyte_Proliferation_in_Hypertrophic_Cardiomyopathy">Inhibition of Cardiac Fibrosis Mediated by Non-Myocyte Proliferation in Hypertrophic Cardiomyopathy</a></div><div class="wp-workCard_item"><span>Journal of the American College of Cardiology</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cccd8678b890d39efcd880b3cd969be4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200551,"asset_id":85528491,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200551/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528491"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528491"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528491; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528491]").text(description); $(".js-view-count[data-work-id=85528491]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528491; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528491']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528491, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cccd8678b890d39efcd880b3cd969be4" } } $('.js-work-strip[data-work-id=85528491]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528491,"title":"Inhibition of Cardiac Fibrosis Mediated by Non-Myocyte Proliferation in Hypertrophic Cardiomyopathy","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Journal of the American College of Cardiology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528491/Inhibition_of_Cardiac_Fibrosis_Mediated_by_Non_Myocyte_Proliferation_in_Hypertrophic_Cardiomyopathy","translated_internal_url":"","created_at":"2022-08-24T07:48:08.005-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200551,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200551/thumbnails/1.jpg","file_name":"81163654.pdf","download_url":"https://www.academia.edu/attachments/90200551/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Inhibition_of_Cardiac_Fibrosis_Mediated.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200551/81163654-libre.pdf?1661355225=\u0026response-content-disposition=attachment%3B+filename%3DInhibition_of_Cardiac_Fibrosis_Mediated.pdf\u0026Expires=1732499582\u0026Signature=Sq5iU4HtO6nEmC37ZXvyQUkRlgA8pCbIEblv1jzlcT3HoHQcBBqSoE1rByLnJTJUdbr9lzJt0k~2a9zJ-gMKztneXGCdyqKaIxUil5vmbLc9EDVxWIYQYYm6XuP2EHkn2hmx-gL7Mnf0COUejDuwtMgFG2NG-WX-IilNz885yO0Kj6h-LPvIN84Eo5C99Tj3svmYDANi5VeAx3si2ZtpBgH1uhoBn347AUf0sPFLXBk04A8OeZbqJkksVeeQGkHFz3Zyv5hX3-HTJyzHYP~F~uzZQe6k49UXmDAeEzHwH-hvhyopECxl5wh9MlUlPnTBwu0bb03iE9hgBzS3CF-WOg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Inhibition_of_Cardiac_Fibrosis_Mediated_by_Non_Myocyte_Proliferation_in_Hypertrophic_Cardiomyopathy","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200551,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200551/thumbnails/1.jpg","file_name":"81163654.pdf","download_url":"https://www.academia.edu/attachments/90200551/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Inhibition_of_Cardiac_Fibrosis_Mediated.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200551/81163654-libre.pdf?1661355225=\u0026response-content-disposition=attachment%3B+filename%3DInhibition_of_Cardiac_Fibrosis_Mediated.pdf\u0026Expires=1732499582\u0026Signature=Sq5iU4HtO6nEmC37ZXvyQUkRlgA8pCbIEblv1jzlcT3HoHQcBBqSoE1rByLnJTJUdbr9lzJt0k~2a9zJ-gMKztneXGCdyqKaIxUil5vmbLc9EDVxWIYQYYm6XuP2EHkn2hmx-gL7Mnf0COUejDuwtMgFG2NG-WX-IilNz885yO0Kj6h-LPvIN84Eo5C99Tj3svmYDANi5VeAx3si2ZtpBgH1uhoBn347AUf0sPFLXBk04A8OeZbqJkksVeeQGkHFz3Zyv5hX3-HTJyzHYP~F~uzZQe6k49UXmDAeEzHwH-hvhyopECxl5wh9MlUlPnTBwu0bb03iE9hgBzS3CF-WOg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1"},{"id":916228,"name":"Hypertrophic Cardiomyopathy","url":"https://www.academia.edu/Documents/in/Hypertrophic_Cardiomyopathy"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528490"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528490/Recruitment_of_bone_marrow_derived_valve_interstitial_cells_is_a_normal_homeostatic_process"><img alt="Research paper thumbnail of Recruitment of bone marrow-derived valve interstitial cells is a normal homeostatic process" class="work-thumbnail" src="https://attachments.academia-assets.com/90200599/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528490/Recruitment_of_bone_marrow_derived_valve_interstitial_cells_is_a_normal_homeostatic_process">Recruitment of bone marrow-derived valve interstitial cells is a normal homeostatic process</a></div><div class="wp-workCard_item"><span>Journal of Molecular and Cellular Cardiology</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="683cc8cc4bbf17efc09201dc08d7ef15" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200599,"asset_id":85528490,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200599/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528490"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528490"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528490; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528490]").text(description); $(".js-view-count[data-work-id=85528490]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528490; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528490']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528490, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "683cc8cc4bbf17efc09201dc08d7ef15" } } $('.js-work-strip[data-work-id=85528490]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528490,"title":"Recruitment of bone marrow-derived valve interstitial cells is a normal homeostatic process","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Journal of Molecular and Cellular Cardiology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528490/Recruitment_of_bone_marrow_derived_valve_interstitial_cells_is_a_normal_homeostatic_process","translated_internal_url":"","created_at":"2022-08-24T07:48:07.894-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200599,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200599/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200599/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Recruitment_of_bone_marrow_derived_valve.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200599/ptpmcrender-libre.pdf?1661355226=\u0026response-content-disposition=attachment%3B+filename%3DRecruitment_of_bone_marrow_derived_valve.pdf\u0026Expires=1732499582\u0026Signature=adikCa1rSHYWgnZXP~lCOAs75MvhlpKzcYywsT4a~satEDMWnBjK5qFC656QKETyVOvi3FN0WYXAuyG-RXhBRQ~QlFm~LbER5pes7KV3bubJ81QCQHxzAILvErtLl2FIfBI0LcswOIFLXqk2EM5jEW3LJ9OiQGIu90fgbJ5pt2f4HyjMSYM1kF~mUB-FXjbKp1jktu7T5876iEvLB6mqj7EuFz6wwjWB8WGJdjUhsCdBBGCJ1F-L2NtVcRkMJQe41d9WXCKerlERloI6vQng7WS4yaJYkzB~9PBqn5OsKbu3x7xAyp~3anOzPG0muWa0AdRcLVBP5b0Bnwgap0cBXg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Recruitment_of_bone_marrow_derived_valve_interstitial_cells_is_a_normal_homeostatic_process","translated_slug":"","page_count":22,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200599,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200599/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200599/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Recruitment_of_bone_marrow_derived_valve.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200599/ptpmcrender-libre.pdf?1661355226=\u0026response-content-disposition=attachment%3B+filename%3DRecruitment_of_bone_marrow_derived_valve.pdf\u0026Expires=1732499582\u0026Signature=adikCa1rSHYWgnZXP~lCOAs75MvhlpKzcYywsT4a~satEDMWnBjK5qFC656QKETyVOvi3FN0WYXAuyG-RXhBRQ~QlFm~LbER5pes7KV3bubJ81QCQHxzAILvErtLl2FIfBI0LcswOIFLXqk2EM5jEW3LJ9OiQGIu90fgbJ5pt2f4HyjMSYM1kF~mUB-FXjbKp1jktu7T5876iEvLB6mqj7EuFz6wwjWB8WGJdjUhsCdBBGCJ1F-L2NtVcRkMJQe41d9WXCKerlERloI6vQng7WS4yaJYkzB~9PBqn5OsKbu3x7xAyp~3anOzPG0muWa0AdRcLVBP5b0Bnwgap0cBXg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":50157,"name":"Molecular","url":"https://www.academia.edu/Documents/in/Molecular"},{"id":53113,"name":"Hematopoietic Stem Cells","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cells"},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":151086,"name":"Peptides","url":"https://www.academia.edu/Documents/in/Peptides"},{"id":159239,"name":"Bone marrow","url":"https://www.academia.edu/Documents/in/Bone_marrow"},{"id":191439,"name":"Glycoproteins","url":"https://www.academia.edu/Documents/in/Glycoproteins"},{"id":323415,"name":"Mouse Model","url":"https://www.academia.edu/Documents/in/Mouse_Model"},{"id":328063,"name":"Heart valves","url":"https://www.academia.edu/Documents/in/Heart_valves"},{"id":379889,"name":"Homeostasis","url":"https://www.academia.edu/Documents/in/Homeostasis"},{"id":405952,"name":"HSC","url":"https://www.academia.edu/Documents/in/HSC"},{"id":1311840,"name":"Heart Valve","url":"https://www.academia.edu/Documents/in/Heart_Valve"},{"id":1664707,"name":"Bone Marrow Cells","url":"https://www.academia.edu/Documents/in/Bone_Marrow_Cells"},{"id":1761225,"name":"Hematopoietic Stem Cell","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cell"},{"id":2374838,"name":"Hematopoietic Stem Cell Transplantation","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cell_Transplantation"},{"id":2481953,"name":"Cardiac function","url":"https://www.academia.edu/Documents/in/Cardiac_function"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"},{"id":4045206,"name":"Collagen type I","url":"https://www.academia.edu/Documents/in/Collagen_type_I"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528489"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528489/Cardiac_fibrosis_in_mice_with_hypertrophic_cardiomyopathy_is_mediated_by_non_myocyte_proliferation_and_requires_Tgf_%CE%B2"><img alt="Research paper thumbnail of Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β" class="work-thumbnail" src="https://attachments.academia-assets.com/90200536/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528489/Cardiac_fibrosis_in_mice_with_hypertrophic_cardiomyopathy_is_mediated_by_non_myocyte_proliferation_and_requires_Tgf_%CE%B2">Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β</a></div><div class="wp-workCard_item"><span>Journal of Clinical Investigation</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b318a13eea9d5ae847816f11488f012f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200536,"asset_id":85528489,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200536/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528489"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528489"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528489; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528489]").text(description); $(".js-view-count[data-work-id=85528489]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528489; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528489']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528489, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b318a13eea9d5ae847816f11488f012f" } } $('.js-work-strip[data-work-id=85528489]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528489,"title":"Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β","translated_title":"","metadata":{"publisher":"American Society for Clinical Investigation","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Journal of Clinical Investigation"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528489/Cardiac_fibrosis_in_mice_with_hypertrophic_cardiomyopathy_is_mediated_by_non_myocyte_proliferation_and_requires_Tgf_%CE%B2","translated_internal_url":"","created_at":"2022-08-24T07:48:07.785-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200536,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200536/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/90200536/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cardiac_fibrosis_in_mice_with_hypertroph.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200536/pdf-libre.pdf?1661355244=\u0026response-content-disposition=attachment%3B+filename%3DCardiac_fibrosis_in_mice_with_hypertroph.pdf\u0026Expires=1732499582\u0026Signature=UNDrGDkIu6K22HsMJ9nrCdtPjOR6-fK5xzFg0sABroW9IeUbAM4rQ74Q3n19Env-swjNFcBznoec0R-HPIpUKDDr87bAf4xmjqU6mN9PUTy2bV-92jKobb~IWB6V5Ht2Fm4AZEmedkTUZrSMawksXjXTkKH57wKaMrH7bIlTbcU2q~tsQMtRleRlLdqoG~F-KanEMoRdKqAJrwSaU6PUBJNE3RvlvPw-pMctLo2geBwbM6k0Ap18STT3tEk2oZ-vrKOtq7wKHHXydPsPFUIc3IftZbnRvVk1HFrTjKO1IlIBA-D0zP9BQZbyHCUFIqWkB~lnsXVuSYouGtVKvuyQKw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Cardiac_fibrosis_in_mice_with_hypertrophic_cardiomyopathy_is_mediated_by_non_myocyte_proliferation_and_requires_Tgf_β","translated_slug":"","page_count":10,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200536,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200536/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/90200536/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cardiac_fibrosis_in_mice_with_hypertroph.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200536/pdf-libre.pdf?1661355244=\u0026response-content-disposition=attachment%3B+filename%3DCardiac_fibrosis_in_mice_with_hypertroph.pdf\u0026Expires=1732499582\u0026Signature=UNDrGDkIu6K22HsMJ9nrCdtPjOR6-fK5xzFg0sABroW9IeUbAM4rQ74Q3n19Env-swjNFcBznoec0R-HPIpUKDDr87bAf4xmjqU6mN9PUTy2bV-92jKobb~IWB6V5Ht2Fm4AZEmedkTUZrSMawksXjXTkKH57wKaMrH7bIlTbcU2q~tsQMtRleRlLdqoG~F-KanEMoRdKqAJrwSaU6PUBJNE3RvlvPw-pMctLo2geBwbM6k0Ap18STT3tEk2oZ-vrKOtq7wKHHXydPsPFUIc3IftZbnRvVk1HFrTjKO1IlIBA-D0zP9BQZbyHCUFIqWkB~lnsXVuSYouGtVKvuyQKw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":130409,"name":"Research article","url":"https://www.academia.edu/Documents/in/Research_article"},{"id":174804,"name":"Fibrosis","url":"https://www.academia.edu/Documents/in/Fibrosis"},{"id":392828,"name":"Myocardium","url":"https://www.academia.edu/Documents/in/Myocardium"},{"id":423549,"name":"Cardiac Fibrosis","url":"https://www.academia.edu/Documents/in/Cardiac_Fibrosis"},{"id":527900,"name":"Transforming Growth Factor Beta","url":"https://www.academia.edu/Documents/in/Transforming_Growth_Factor_Beta"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation"},{"id":788694,"name":"Losartan","url":"https://www.academia.edu/Documents/in/Losartan"},{"id":916228,"name":"Hypertrophic Cardiomyopathy","url":"https://www.academia.edu/Documents/in/Hypertrophic_Cardiomyopathy"},{"id":1144154,"name":"Clinical Investigation","url":"https://www.academia.edu/Documents/in/Clinical_Investigation"},{"id":2616306,"name":"Myocardial fibrosis","url":"https://www.academia.edu/Documents/in/Myocardial_fibrosis"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528487"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528487/Towards_organ_printing_engineering_an_intra_organ_branched_vascular_tree"><img alt="Research paper thumbnail of Towards organ printing: engineering an intra-organ branched vascular tree" class="work-thumbnail" src="https://attachments.academia-assets.com/90200531/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528487/Towards_organ_printing_engineering_an_intra_organ_branched_vascular_tree">Towards organ printing: engineering an intra-organ branched vascular tree</a></div><div class="wp-workCard_item"><span>Expert Opinion on Biological Therapy</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="42d90984a777eb29ad4cdab84d729bb1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200531,"asset_id":85528487,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200531/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528487"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528487"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528487; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528487]").text(description); $(".js-view-count[data-work-id=85528487]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528487; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528487']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528487, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "42d90984a777eb29ad4cdab84d729bb1" } } $('.js-work-strip[data-work-id=85528487]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528487,"title":"Towards organ printing: engineering an intra-organ branched vascular tree","translated_title":"","metadata":{"publisher":"Informa Healthcare","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Expert Opinion on Biological Therapy"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528487/Towards_organ_printing_engineering_an_intra_organ_branched_vascular_tree","translated_internal_url":"","created_at":"2022-08-24T07:48:07.623-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200531,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200531/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200531/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Towards_organ_printing_engineering_an_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200531/ptpmcrender-libre.pdf?1661355227=\u0026response-content-disposition=attachment%3B+filename%3DTowards_organ_printing_engineering_an_in.pdf\u0026Expires=1732499582\u0026Signature=br6GWRmqwbjp0Wq3fpTY2Dw1hGVjkrdFYYUW1lPvUzQXLuZHi2OnG~A-uAxrN6fsxEWNUCIk1mdSKbL2LZSiptp2WZfzAAwFhuYMuCsJQRSJQ~TMYEuFK4ogfUeGvnjTj1bNobkaKZrdrr4PzR00wvkHqN3MH5H9MgHyUZkEMJJnR2TyKjVqf5hWq0hsgCTH839Tt0F~3OVeUIqFNkT592bfGUt9Q8dHyJdfE6crcoLbg0YZ8edc4~pTtfNC8JdoR2nafEaN4fZhFauTETCfsoEYsKRp8vJhGfO3BYkzbY88mARPI64M1rL3PUzwzS2jHfT1uNkZr3bNwcs9aRRlmw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Towards_organ_printing_engineering_an_intra_organ_branched_vascular_tree","translated_slug":"","page_count":21,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200531,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200531/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200531/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Towards_organ_printing_engineering_an_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200531/ptpmcrender-libre.pdf?1661355227=\u0026response-content-disposition=attachment%3B+filename%3DTowards_organ_printing_engineering_an_in.pdf\u0026Expires=1732499582\u0026Signature=br6GWRmqwbjp0Wq3fpTY2Dw1hGVjkrdFYYUW1lPvUzQXLuZHi2OnG~A-uAxrN6fsxEWNUCIk1mdSKbL2LZSiptp2WZfzAAwFhuYMuCsJQRSJQ~TMYEuFK4ogfUeGvnjTj1bNobkaKZrdrr4PzR00wvkHqN3MH5H9MgHyUZkEMJJnR2TyKjVqf5hWq0hsgCTH839Tt0F~3OVeUIqFNkT592bfGUt9Q8dHyJdfE6crcoLbg0YZ8edc4~pTtfNC8JdoR2nafEaN4fZhFauTETCfsoEYsKRp8vJhGfO3BYkzbY88mARPI64M1rL3PUzwzS2jHfT1uNkZr3bNwcs9aRRlmw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":77,"name":"Robotics","url":"https://www.academia.edu/Documents/in/Robotics"},{"id":2699,"name":"Tissue Engineering","url":"https://www.academia.edu/Documents/in/Tissue_Engineering"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":100540,"name":"Feasibility Studies","url":"https://www.academia.edu/Documents/in/Feasibility_Studies"},{"id":178994,"name":"Vascular tissue engineering","url":"https://www.academia.edu/Documents/in/Vascular_tissue_engineering"},{"id":216119,"name":"Biofabrication","url":"https://www.academia.edu/Documents/in/Biofabrication"},{"id":557543,"name":"Blood Vessels","url":"https://www.academia.edu/Documents/in/Blood_Vessels"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23312392,"url":"http://www.tandfonline.com/doi/pdf/10.1517/14712590903563352"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528485"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528485/American_Association_of_Anatomists_meeting_on_regenerative_medicine"><img alt="Research paper thumbnail of American Association of Anatomists meeting on regenerative medicine" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528485/American_Association_of_Anatomists_meeting_on_regenerative_medicine">American Association of Anatomists meeting on regenerative medicine</a></div><div class="wp-workCard_item"><span>Expert Opinion on Biological Therapy</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Several years ago, the American Association of Anatomists (AAA) launched an innovative mini-meeti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Several years ago, the American Association of Anatomists (AAA) launched an innovative mini-meeting format as part of their annual meeting. The AAA continued this tradition by sponsoring a 2-day mini-symposium as a part of its meeting at FASEB Experimental Biology, 2006 in San Francisco, CA, USA. This year, the mini-symposium was focused on the promising and rapidly developing field of &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;regenerative medicine&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;. The mini-symposium on &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;regenerative medicine&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; included four separate but thematically integrated sessions: stem cells for regenerative medicine; biomimetic matrices for regenerative medicine; endothelial-mesenchymal transformation in cardiovascular regenerative medicine; and tissue engineering technologies for regenerative medicine. The goal of these sessions was to identify progress and highlight new trends and directions in the evolving field of regenerative medicine. It was an exciting 2-day mini-symposium that reviewed the differential potential of embryonic and adult stem cells, their role in tissue turnover and possible applications in tissue regeneration; identified important evolving basic science issues, such as the role of endothelial-mesenchymal transformation and stem cell recruitment in cardiovascular regenerative medicine; and, finally, clearly demonstrated how understanding basic scientific principles can be translated into novel cell therapeutics and tissue engineering modalities. The workshop also demonstrated the multidisciplinary (speakers included stem cell and developmental biologists, chemical engineers, tissue engineers, biophysicists, mathematicians and surgeons) and international (speakers represented US, Japan, Canada, Switzerland and Korea) character of ongoing efforts in the area of regenerative medicine and stem cell biology, impressive progress in this field, and confirmed the strong potential for clinical translation of emerging regenerative medicine technologies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528485"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528485"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528485; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528485]").text(description); $(".js-view-count[data-work-id=85528485]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528485; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528485']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528485, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=85528485]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528485,"title":"American Association of Anatomists meeting on regenerative medicine","translated_title":"","metadata":{"abstract":"Several years ago, the American Association of Anatomists (AAA) launched an innovative mini-meeting format as part of their annual meeting. The AAA continued this tradition by sponsoring a 2-day mini-symposium as a part of its meeting at FASEB Experimental Biology, 2006 in San Francisco, CA, USA. This year, the mini-symposium was focused on the promising and rapidly developing field of \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;regenerative medicine\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;. The mini-symposium on \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;regenerative medicine\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; included four separate but thematically integrated sessions: stem cells for regenerative medicine; biomimetic matrices for regenerative medicine; endothelial-mesenchymal transformation in cardiovascular regenerative medicine; and tissue engineering technologies for regenerative medicine. The goal of these sessions was to identify progress and highlight new trends and directions in the evolving field of regenerative medicine. It was an exciting 2-day mini-symposium that reviewed the differential potential of embryonic and adult stem cells, their role in tissue turnover and possible applications in tissue regeneration; identified important evolving basic science issues, such as the role of endothelial-mesenchymal transformation and stem cell recruitment in cardiovascular regenerative medicine; and, finally, clearly demonstrated how understanding basic scientific principles can be translated into novel cell therapeutics and tissue engineering modalities. The workshop also demonstrated the multidisciplinary (speakers included stem cell and developmental biologists, chemical engineers, tissue engineers, biophysicists, mathematicians and surgeons) and international (speakers represented US, Japan, Canada, Switzerland and Korea) character of ongoing efforts in the area of regenerative medicine and stem cell biology, impressive progress in this field, and confirmed the strong potential for clinical translation of emerging regenerative medicine technologies.","publisher":"Informa Healthcare","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Expert Opinion on Biological Therapy"},"translated_abstract":"Several years ago, the American Association of Anatomists (AAA) launched an innovative mini-meeting format as part of their annual meeting. The AAA continued this tradition by sponsoring a 2-day mini-symposium as a part of its meeting at FASEB Experimental Biology, 2006 in San Francisco, CA, USA. This year, the mini-symposium was focused on the promising and rapidly developing field of \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;regenerative medicine\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;. The mini-symposium on \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;regenerative medicine\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; included four separate but thematically integrated sessions: stem cells for regenerative medicine; biomimetic matrices for regenerative medicine; endothelial-mesenchymal transformation in cardiovascular regenerative medicine; and tissue engineering technologies for regenerative medicine. The goal of these sessions was to identify progress and highlight new trends and directions in the evolving field of regenerative medicine. It was an exciting 2-day mini-symposium that reviewed the differential potential of embryonic and adult stem cells, their role in tissue turnover and possible applications in tissue regeneration; identified important evolving basic science issues, such as the role of endothelial-mesenchymal transformation and stem cell recruitment in cardiovascular regenerative medicine; and, finally, clearly demonstrated how understanding basic scientific principles can be translated into novel cell therapeutics and tissue engineering modalities. The workshop also demonstrated the multidisciplinary (speakers included stem cell and developmental biologists, chemical engineers, tissue engineers, biophysicists, mathematicians and surgeons) and international (speakers represented US, Japan, Canada, Switzerland and Korea) character of ongoing efforts in the area of regenerative medicine and stem cell biology, impressive progress in this field, and confirmed the strong potential for clinical translation of emerging regenerative medicine technologies.","internal_url":"https://www.academia.edu/85528485/American_Association_of_Anatomists_meeting_on_regenerative_medicine","translated_internal_url":"","created_at":"2022-08-24T07:48:07.477-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"American_Association_of_Anatomists_meeting_on_regenerative_medicine","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[],"research_interests":[{"id":2699,"name":"Tissue Engineering","url":"https://www.academia.edu/Documents/in/Tissue_Engineering"},{"id":3642,"name":"Stem Cells","url":"https://www.academia.edu/Documents/in/Stem_Cells"},{"id":25550,"name":"Regenerative Medicine","url":"https://www.academia.edu/Documents/in/Regenerative_Medicine"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":54589,"name":"Anatomy","url":"https://www.academia.edu/Documents/in/Anatomy"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98134,"name":"United States","url":"https://www.academia.edu/Documents/in/United_States"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23312391,"url":"http://www.tandfonline.com/doi/pdf/10.1517/14712598.6.7.727"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528484"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528484/What_is_regenerative_medicine_Emergence_of_applied_stem_cell_and_developmental_biology"><img alt="Research paper thumbnail of What is regenerative medicine? Emergence of applied stem cell and developmental biology" class="work-thumbnail" src="https://attachments.academia-assets.com/90200529/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528484/What_is_regenerative_medicine_Emergence_of_applied_stem_cell_and_developmental_biology">What is regenerative medicine? Emergence of applied stem cell and developmental biology</a></div><div class="wp-workCard_item"><span>Expert Opinion on Biological Therapy</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="03c851b343cc8e8d7c7614cb67ecfec8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200529,"asset_id":85528484,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200529/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528484"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528484"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528484; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528484]").text(description); $(".js-view-count[data-work-id=85528484]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528484; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528484']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528484, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "03c851b343cc8e8d7c7614cb67ecfec8" } } $('.js-work-strip[data-work-id=85528484]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528484,"title":"What is regenerative medicine? Emergence of applied stem cell and developmental biology","translated_title":"","metadata":{"publisher":"Informa Healthcare","publication_date":{"day":null,"month":null,"year":2004,"errors":{}},"publication_name":"Expert Opinion on Biological Therapy"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528484/What_is_regenerative_medicine_Emergence_of_applied_stem_cell_and_developmental_biology","translated_internal_url":"","created_at":"2022-08-24T07:48:07.324-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200529,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200529/thumbnails/1.jpg","file_name":"14712598.4.6.77320220824-1-mjc6zs.pdf","download_url":"https://www.academia.edu/attachments/90200529/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"What_is_regenerative_medicine_Emergence.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200529/14712598.4.6.77320220824-1-mjc6zs-libre.pdf?1661355232=\u0026response-content-disposition=attachment%3B+filename%3DWhat_is_regenerative_medicine_Emergence.pdf\u0026Expires=1732499583\u0026Signature=erjYIuIogiNGmfu80QxwEhV1c2i7AWI-87QNu1aAnOJyNEuHrEqeeTEQxBs33zALA5cMN-sRsuERd1k-CvgPyYovQ54zccrKvK~D0KE7IokDJK5fI1cWHee3NkgvQ17~ppzFOgX4aefE5GVOvB~XyEAINYXi0JDweKbvzDUb64mtCd2wySSfsksfg2amnXfCg0vI1MkaEMN94Tu0GNvjRCKppc46h0sIkbvOqYRPawhYs5ofDJANGtPSOcafR-Fdj9BGE6NdJTEXio2-hxBRSa6cY7Wp-3VqCmG756thl7R6tkl3~CvJDa3wqVPnRRi6EBfPRibobaEMULVgSSrxYQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"What_is_regenerative_medicine_Emergence_of_applied_stem_cell_and_developmental_biology","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200529,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200529/thumbnails/1.jpg","file_name":"14712598.4.6.77320220824-1-mjc6zs.pdf","download_url":"https://www.academia.edu/attachments/90200529/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"What_is_regenerative_medicine_Emergence.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200529/14712598.4.6.77320220824-1-mjc6zs-libre.pdf?1661355232=\u0026response-content-disposition=attachment%3B+filename%3DWhat_is_regenerative_medicine_Emergence.pdf\u0026Expires=1732499583\u0026Signature=erjYIuIogiNGmfu80QxwEhV1c2i7AWI-87QNu1aAnOJyNEuHrEqeeTEQxBs33zALA5cMN-sRsuERd1k-CvgPyYovQ54zccrKvK~D0KE7IokDJK5fI1cWHee3NkgvQ17~ppzFOgX4aefE5GVOvB~XyEAINYXi0JDweKbvzDUb64mtCd2wySSfsksfg2amnXfCg0vI1MkaEMN94Tu0GNvjRCKppc46h0sIkbvOqYRPawhYs5ofDJANGtPSOcafR-Fdj9BGE6NdJTEXio2-hxBRSa6cY7Wp-3VqCmG756thl7R6tkl3~CvJDa3wqVPnRRi6EBfPRibobaEMULVgSSrxYQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":23163,"name":"Stem Cell","url":"https://www.academia.edu/Documents/in/Stem_Cell"},{"id":25550,"name":"Regenerative Medicine","url":"https://www.academia.edu/Documents/in/Regenerative_Medicine"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":23312390,"url":"http://www.tandfonline.com/doi/pdf/10.1517/14712598.4.6.773"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528483"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528483/On_the_Role_of_Shear_Stress_in_Cardiogenesis"><img alt="Research paper thumbnail of On the Role of Shear Stress in Cardiogenesis" class="work-thumbnail" src="https://attachments.academia-assets.com/90200530/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528483/On_the_Role_of_Shear_Stress_in_Cardiogenesis">On the Role of Shear Stress in Cardiogenesis</a></div><div class="wp-workCard_item"><span>Endothelium</span><span>, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="df8d3c871d1b349c5fcc63ffd0f65682" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200530,"asset_id":85528483,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200530/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528483"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528483"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528483; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528483]").text(description); $(".js-view-count[data-work-id=85528483]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528483; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528483']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528483, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "df8d3c871d1b349c5fcc63ffd0f65682" } } $('.js-work-strip[data-work-id=85528483]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528483,"title":"On the Role of Shear Stress in Cardiogenesis","translated_title":"","metadata":{"publisher":"Informa UK Limited","publication_date":{"day":null,"month":null,"year":2005,"errors":{}},"publication_name":"Endothelium"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528483/On_the_Role_of_Shear_Stress_in_Cardiogenesis","translated_internal_url":"","created_at":"2022-08-24T07:48:07.128-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200530,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200530/thumbnails/1.jpg","file_name":"1062332050047670820220824-1-1qu6kz9.pdf","download_url":"https://www.academia.edu/attachments/90200530/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"On_the_Role_of_Shear_Stress_in_Cardiogen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200530/1062332050047670820220824-1-1qu6kz9-libre.pdf?1661355226=\u0026response-content-disposition=attachment%3B+filename%3DOn_the_Role_of_Shear_Stress_in_Cardiogen.pdf\u0026Expires=1732499583\u0026Signature=Zt5swWhMIJvoWJ4MuagJRCpWVlJ8GG6-Z8O4Zac~j-42J9-qpy3nKst9~oaB0-QjqgjHto2S5Mrgi5xZ~szPLPnCpB35aVLet-kAIXpEZAECRUW6vUnjj~VAENxhXUC0I8ki70roLMupfiU5lj4jeAuRX0npKvwkSzoLeHwGuYeczH9mA4lSbwZy8t9K9QOC14luGmg8KJi1FTZX0~jJLKk7Q8OR8VJI4x2JA14UZ3MPqhHRepBh129hbP~-PDFtd7o-DV0f8oEHeg9KapoOesrWIx6d4NukbBVeJwJZxTePLDadlZFrmcjX1DNacuY03c-ME7KtwyL11DAXzkljjA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"On_the_Role_of_Shear_Stress_in_Cardiogenesis","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200530,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200530/thumbnails/1.jpg","file_name":"1062332050047670820220824-1-1qu6kz9.pdf","download_url":"https://www.academia.edu/attachments/90200530/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"On_the_Role_of_Shear_Stress_in_Cardiogen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200530/1062332050047670820220824-1-1qu6kz9-libre.pdf?1661355226=\u0026response-content-disposition=attachment%3B+filename%3DOn_the_Role_of_Shear_Stress_in_Cardiogen.pdf\u0026Expires=1732499583\u0026Signature=Zt5swWhMIJvoWJ4MuagJRCpWVlJ8GG6-Z8O4Zac~j-42J9-qpy3nKst9~oaB0-QjqgjHto2S5Mrgi5xZ~szPLPnCpB35aVLet-kAIXpEZAECRUW6vUnjj~VAENxhXUC0I8ki70roLMupfiU5lj4jeAuRX0npKvwkSzoLeHwGuYeczH9mA4lSbwZy8t9K9QOC14luGmg8KJi1FTZX0~jJLKk7Q8OR8VJI4x2JA14UZ3MPqhHRepBh129hbP~-PDFtd7o-DV0f8oEHeg9KapoOesrWIx6d4NukbBVeJwJZxTePLDadlZFrmcjX1DNacuY03c-ME7KtwyL11DAXzkljjA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":131495,"name":"Heart","url":"https://www.academia.edu/Documents/in/Heart"},{"id":175859,"name":"Shear Stress","url":"https://www.academia.edu/Documents/in/Shear_Stress"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":350931,"name":"Mechanical Stress","url":"https://www.academia.edu/Documents/in/Mechanical_Stress"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1"},{"id":788667,"name":"ENDOTHELIUM","url":"https://www.academia.edu/Documents/in/ENDOTHELIUM"},{"id":908227,"name":"Organogenesis","url":"https://www.academia.edu/Documents/in/Organogenesis"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":23312389,"url":"http://www.tandfonline.com/doi/pdf/10.1080/10623320500476708"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528482"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528482/Atrioventricular_valve_development_New_perspectives_on_an_old_theme"><img alt="Research paper thumbnail of Atrioventricular valve development: New perspectives on an old theme" class="work-thumbnail" src="https://attachments.academia-assets.com/90200594/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528482/Atrioventricular_valve_development_New_perspectives_on_an_old_theme">Atrioventricular valve development: New perspectives on an old theme</a></div><div class="wp-workCard_item"><span>Differentiation</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="589eded4a5476665474b4e3d0ce78403" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200594,"asset_id":85528482,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200594/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528482"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528482"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528482; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528482]").text(description); $(".js-view-count[data-work-id=85528482]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528482; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528482']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528482, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "589eded4a5476665474b4e3d0ce78403" } } $('.js-work-strip[data-work-id=85528482]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528482,"title":"Atrioventricular valve development: New perspectives on an old theme","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Differentiation"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528482/Atrioventricular_valve_development_New_perspectives_on_an_old_theme","translated_internal_url":"","created_at":"2022-08-24T07:48:06.984-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200594,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200594/thumbnails/1.jpg","file_name":"j.diff.2012.04.00120220824-1-1tnfrda.pdf","download_url":"https://www.academia.edu/attachments/90200594/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Atrioventricular_valve_development_New_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200594/j.diff.2012.04.00120220824-1-1tnfrda-libre.pdf?1661355222=\u0026response-content-disposition=attachment%3B+filename%3DAtrioventricular_valve_development_New_p.pdf\u0026Expires=1732499583\u0026Signature=hSuIZGmewROi5ISrbVlvxD7dlE3aHb2Ij-rLzO1mupkqgmkHLeg~0jZcoGp~azOuDvAiiHiBnn3rYECTBRDU75E~28sro~qKKAffrurYl7vH8VrFCzf3pJltfykcHwkIxCGp9qb~HPqtIF9nYT8U8mapKV-ez3J9t7TWtnR3jnYt1omLZc6FOtc-e511pX00Z5PYneRcUXulX0i6YCkHKhBLxWZliJL78yGRMluacY6jI4JXBZpo1h8GWk-fe~KbTF11d-lG-o8m-A0d6wxepBb05YSUURmLE4-5wEVJe4jIbNDFNzlszIOmfanMU-5xo3~Y95tmfyAMAf-u2b~evA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Atrioventricular_valve_development_New_perspectives_on_an_old_theme","translated_slug":"","page_count":14,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200594,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200594/thumbnails/1.jpg","file_name":"j.diff.2012.04.00120220824-1-1tnfrda.pdf","download_url":"https://www.academia.edu/attachments/90200594/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Atrioventricular_valve_development_New_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200594/j.diff.2012.04.00120220824-1-1tnfrda-libre.pdf?1661355222=\u0026response-content-disposition=attachment%3B+filename%3DAtrioventricular_valve_development_New_p.pdf\u0026Expires=1732499583\u0026Signature=hSuIZGmewROi5ISrbVlvxD7dlE3aHb2Ij-rLzO1mupkqgmkHLeg~0jZcoGp~azOuDvAiiHiBnn3rYECTBRDU75E~28sro~qKKAffrurYl7vH8VrFCzf3pJltfykcHwkIxCGp9qb~HPqtIF9nYT8U8mapKV-ez3J9t7TWtnR3jnYt1omLZc6FOtc-e511pX00Z5PYneRcUXulX0i6YCkHKhBLxWZliJL78yGRMluacY6jI4JXBZpo1h8GWk-fe~KbTF11d-lG-o8m-A0d6wxepBb05YSUURmLE4-5wEVJe4jIbNDFNzlszIOmfanMU-5xo3~Y95tmfyAMAf-u2b~evA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":29149,"name":"Extracellular Matrix","url":"https://www.academia.edu/Documents/in/Extracellular_Matrix"},{"id":57980,"name":"Congenital Heart Defects","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Defects"},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":71510,"name":"Endothelial Cells","url":"https://www.academia.edu/Documents/in/Endothelial_Cells"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":194810,"name":"Differentiation","url":"https://www.academia.edu/Documents/in/Differentiation"},{"id":231933,"name":"Mitral Valve Repair","url":"https://www.academia.edu/Documents/in/Mitral_Valve_Repair"},{"id":328063,"name":"Heart valves","url":"https://www.academia.edu/Documents/in/Heart_valves"},{"id":954995,"name":"Human Fibroblasts","url":"https://www.academia.edu/Documents/in/Human_Fibroblasts"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":2533047,"name":"fibroblasts","url":"https://www.academia.edu/Documents/in/fibroblasts"},{"id":3675689,"name":"Chick embryo","url":"https://www.academia.edu/Documents/in/Chick_embryo"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"},{"id":3910249,"name":"endocardium","url":"https://www.academia.edu/Documents/in/endocardium"},{"id":4045206,"name":"Collagen type I","url":"https://www.academia.edu/Documents/in/Collagen_type_I"},{"id":4114205,"name":"Mitral valve","url":"https://www.academia.edu/Documents/in/Mitral_valve-1"}],"urls":[{"id":23312388,"url":"https://api.elsevier.com/content/article/PII:S030146811200062X?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528481"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528481/Organ_printing_Tissue_spheroids_as_building_blocks"><img alt="Research paper thumbnail of Organ printing: Tissue spheroids as building blocks" class="work-thumbnail" src="https://attachments.academia-assets.com/90200532/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528481/Organ_printing_Tissue_spheroids_as_building_blocks">Organ printing: Tissue spheroids as building blocks</a></div><div class="wp-workCard_item"><span>Biomaterials</span><span>, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ccd5a0488494255fa8de3483821cbbd1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200532,"asset_id":85528481,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200532/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528481"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528481"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528481; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528481]").text(description); $(".js-view-count[data-work-id=85528481]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528481; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528481']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528481, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ccd5a0488494255fa8de3483821cbbd1" } } $('.js-work-strip[data-work-id=85528481]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528481,"title":"Organ printing: Tissue spheroids as building blocks","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"Biomaterials"},"translated_abstract":null,"internal_url":"https://www.academia.edu/85528481/Organ_printing_Tissue_spheroids_as_building_blocks","translated_internal_url":"","created_at":"2022-08-24T07:48:06.828-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200532,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200532/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200532/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Organ_printing_Tissue_spheroids_as_build.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200532/ptpmcrender.pdf?1661352555=\u0026response-content-disposition=attachment%3B+filename%3DOrgan_printing_Tissue_spheroids_as_build.pdf\u0026Expires=1732499583\u0026Signature=VnldKor9L0Nt4WyQuG3mD~J9lpfUUwYiqYXgwkJdLkID9xLs~DVNBm2QdVUy2xmiPGI2qMiiWl0XYYRGAB~-QbxbipYzDDNy7iG5q7nLbF2atuePkIOAFk7U~Bxm7~FeBF0zghUfEosOaJM1A6Ww9O3CoAeRnm5NHGlMgp-l4W28WYeLek-eHw8hX8c4Rbj-sLmnonjKbsGVjkNCVnHr2pQavhPL1WCTxdnDpkYAfFe1ei3BsbO2TheONzlh3g~zmS2FXfCLp6e2wfLb6s-H7ewMN7mm8xESbQKhEYjJDSNprs3s782dIiSqMCPyG1NaL1xOEqaYzO-Ls8hKbzmGxw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Organ_printing_Tissue_spheroids_as_building_blocks","translated_slug":"","page_count":22,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200532,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200532/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/90200532/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Organ_printing_Tissue_spheroids_as_build.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200532/ptpmcrender.pdf?1661352555=\u0026response-content-disposition=attachment%3B+filename%3DOrgan_printing_Tissue_spheroids_as_build.pdf\u0026Expires=1732499583\u0026Signature=VnldKor9L0Nt4WyQuG3mD~J9lpfUUwYiqYXgwkJdLkID9xLs~DVNBm2QdVUy2xmiPGI2qMiiWl0XYYRGAB~-QbxbipYzDDNy7iG5q7nLbF2atuePkIOAFk7U~Bxm7~FeBF0zghUfEosOaJM1A6Ww9O3CoAeRnm5NHGlMgp-l4W28WYeLek-eHw8hX8c4Rbj-sLmnonjKbsGVjkNCVnHr2pQavhPL1WCTxdnDpkYAfFe1ei3BsbO2TheONzlh3g~zmS2FXfCLp6e2wfLb6s-H7ewMN7mm8xESbQKhEYjJDSNprs3s782dIiSqMCPyG1NaL1xOEqaYzO-Ls8hKbzmGxw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1083,"name":"Developmental Biology","url":"https://www.academia.edu/Documents/in/Developmental_Biology"},{"id":2698,"name":"Biomaterials","url":"https://www.academia.edu/Documents/in/Biomaterials"},{"id":2699,"name":"Tissue Engineering","url":"https://www.academia.edu/Documents/in/Tissue_Engineering"},{"id":11073,"name":"Self Assembly","url":"https://www.academia.edu/Documents/in/Self_Assembly"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":69542,"name":"Computer Simulation","url":"https://www.academia.edu/Documents/in/Computer_Simulation"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":169323,"name":"Composite Material","url":"https://www.academia.edu/Documents/in/Composite_Material"},{"id":188197,"name":"Industrial Robots","url":"https://www.academia.edu/Documents/in/Industrial_Robots"},{"id":401996,"name":"Layer by Layer","url":"https://www.academia.edu/Documents/in/Layer_by_Layer"},{"id":451298,"name":"3-D printing","url":"https://www.academia.edu/Documents/in/3-D_printing"},{"id":504035,"name":"Three Dimensional","url":"https://www.academia.edu/Documents/in/Three_Dimensional"},{"id":758278,"name":"Large Scale","url":"https://www.academia.edu/Documents/in/Large_Scale"}],"urls":[{"id":23312387,"url":"https://api.elsevier.com/content/article/PII:S0142961209000052?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="85528460"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/85528460/An_In_Vivo_Analysis_of_Hematopoietic_Stem_Cell_Potential"><img alt="Research paper thumbnail of An In Vivo Analysis of Hematopoietic Stem Cell Potential" class="work-thumbnail" src="https://attachments.academia-assets.com/90200559/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/85528460/An_In_Vivo_Analysis_of_Hematopoietic_Stem_Cell_Potential">An In Vivo Analysis of Hematopoietic Stem Cell Potential</a></div><div class="wp-workCard_item"><span>Circulation Research</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Recent studies evaluating hematopoietic stem cell (HSC) potential raise the possibility that, in ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Recent studies evaluating hematopoietic stem cell (HSC) potential raise the possibility that, in addition to embryonic sources, adult valve fibroblasts may be derived from HSCs. To test this hypothesis, we used methods that allow the potential of a single HSC to be evaluated in vivo. This was achieved by isolation and clonal expansion of single lineage-negative (Lin − ), c-kit + , Sca-1 + , CD34 − cells from the bone marrow of mice that ubiquitously express enhanced green fluorescent protein (EGFP) combined with transplantation of individual clonal populations derived from these candidate HSCs into a lethally irradiated congenic non-EGFP mouse. Histological analyses of valve tissue from clonally engrafted recipient mice revealed the presence of numerous EGFP + cells within host valves. A subpopulation of these cells exhibited synthetic properties characteristic of fibroblasts, as evidenced by their expression of mRNA for procollagen 1α1. Further, we show by Y-chromosome–specific flu...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4f00fd41c2685a20a9a0bfdba6419236" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":90200559,"asset_id":85528460,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/90200559/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="85528460"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="85528460"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 85528460; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=85528460]").text(description); $(".js-view-count[data-work-id=85528460]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 85528460; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='85528460']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 85528460, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4f00fd41c2685a20a9a0bfdba6419236" } } $('.js-work-strip[data-work-id=85528460]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":85528460,"title":"An In Vivo Analysis of Hematopoietic Stem Cell Potential","translated_title":"","metadata":{"abstract":"Recent studies evaluating hematopoietic stem cell (HSC) potential raise the possibility that, in addition to embryonic sources, adult valve fibroblasts may be derived from HSCs. To test this hypothesis, we used methods that allow the potential of a single HSC to be evaluated in vivo. This was achieved by isolation and clonal expansion of single lineage-negative (Lin − ), c-kit + , Sca-1 + , CD34 − cells from the bone marrow of mice that ubiquitously express enhanced green fluorescent protein (EGFP) combined with transplantation of individual clonal populations derived from these candidate HSCs into a lethally irradiated congenic non-EGFP mouse. Histological analyses of valve tissue from clonally engrafted recipient mice revealed the presence of numerous EGFP + cells within host valves. A subpopulation of these cells exhibited synthetic properties characteristic of fibroblasts, as evidenced by their expression of mRNA for procollagen 1α1. Further, we show by Y-chromosome–specific flu...","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Circulation Research"},"translated_abstract":"Recent studies evaluating hematopoietic stem cell (HSC) potential raise the possibility that, in addition to embryonic sources, adult valve fibroblasts may be derived from HSCs. To test this hypothesis, we used methods that allow the potential of a single HSC to be evaluated in vivo. This was achieved by isolation and clonal expansion of single lineage-negative (Lin − ), c-kit + , Sca-1 + , CD34 − cells from the bone marrow of mice that ubiquitously express enhanced green fluorescent protein (EGFP) combined with transplantation of individual clonal populations derived from these candidate HSCs into a lethally irradiated congenic non-EGFP mouse. Histological analyses of valve tissue from clonally engrafted recipient mice revealed the presence of numerous EGFP + cells within host valves. A subpopulation of these cells exhibited synthetic properties characteristic of fibroblasts, as evidenced by their expression of mRNA for procollagen 1α1. Further, we show by Y-chromosome–specific flu...","internal_url":"https://www.academia.edu/85528460/An_In_Vivo_Analysis_of_Hematopoietic_Stem_Cell_Potential","translated_internal_url":"","created_at":"2022-08-24T07:47:35.003-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":90200559,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200559/thumbnails/1.jpg","file_name":"690.full.pdf","download_url":"https://www.academia.edu/attachments/90200559/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"An_In_Vivo_Analysis_of_Hematopoietic_Ste.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200559/690.full-libre.pdf?1661355224=\u0026response-content-disposition=attachment%3B+filename%3DAn_In_Vivo_Analysis_of_Hematopoietic_Ste.pdf\u0026Expires=1732499583\u0026Signature=ZgS8OD9d2pjf1w~H3iLg7ixmEOW~UdHDbAdAYnh257HuhitkxXefmeYMF65LBfvbfQSUULUr64ooY8NRP0xlnsBMW4ZCDu2t8g4aKe1eWX~-IqORdDE3JvKmKTuJ~lCjWG2Rlc2d-v~WkxbVTJrAaPG~Y~5SYaaU5BUZege2x1ilHz8seh4INokbvdvF1LcUQmrv82EcVf~3tY510ojujLKgxPm1zunsm26yG16W9dGGOPA~ZZE-CLNo0pL3NtVcHq~XO9LKg6ZzpnlFcgNaZp0d8d2D63fZyqBWn~9UdQp5JjDTLFPt7-D3ytb6SAY5BYuoLwPpE1olo9kFM4n~Gg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"An_In_Vivo_Analysis_of_Hematopoietic_Stem_Cell_Potential","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":90200559,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/90200559/thumbnails/1.jpg","file_name":"690.full.pdf","download_url":"https://www.academia.edu/attachments/90200559/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"An_In_Vivo_Analysis_of_Hematopoietic_Ste.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/90200559/690.full-libre.pdf?1661355224=\u0026response-content-disposition=attachment%3B+filename%3DAn_In_Vivo_Analysis_of_Hematopoietic_Ste.pdf\u0026Expires=1732499583\u0026Signature=ZgS8OD9d2pjf1w~H3iLg7ixmEOW~UdHDbAdAYnh257HuhitkxXefmeYMF65LBfvbfQSUULUr64ooY8NRP0xlnsBMW4ZCDu2t8g4aKe1eWX~-IqORdDE3JvKmKTuJ~lCjWG2Rlc2d-v~WkxbVTJrAaPG~Y~5SYaaU5BUZege2x1ilHz8seh4INokbvdvF1LcUQmrv82EcVf~3tY510ojujLKgxPm1zunsm26yG16W9dGGOPA~ZZE-CLNo0pL3NtVcHq~XO9LKg6ZzpnlFcgNaZp0d8d2D63fZyqBWn~9UdQp5JjDTLFPt7-D3ytb6SAY5BYuoLwPpE1olo9kFM4n~Gg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":18608,"name":"Adult Stem Cells","url":"https://www.academia.edu/Documents/in/Adult_Stem_Cells"},{"id":37866,"name":"Hematopoiesis","url":"https://www.academia.edu/Documents/in/Hematopoiesis"},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":159239,"name":"Bone marrow","url":"https://www.academia.edu/Documents/in/Bone_marrow"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":302037,"name":"In Vivo","url":"https://www.academia.edu/Documents/in/In_Vivo"},{"id":328063,"name":"Heart valves","url":"https://www.academia.edu/Documents/in/Heart_valves"},{"id":376291,"name":"Fluorescent in situ hybridization","url":"https://www.academia.edu/Documents/in/Fluorescent_in_situ_hybridization"},{"id":515070,"name":"Circulation","url":"https://www.academia.edu/Documents/in/Circulation"},{"id":954995,"name":"Human Fibroblasts","url":"https://www.academia.edu/Documents/in/Human_Fibroblasts"},{"id":1320085,"name":"Adult Stem Cell","url":"https://www.academia.edu/Documents/in/Adult_Stem_Cell"},{"id":1761225,"name":"Hematopoietic Stem Cell","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cell"},{"id":2374838,"name":"Hematopoietic Stem Cell Transplantation","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cell_Transplantation"},{"id":2533047,"name":"fibroblasts","url":"https://www.academia.edu/Documents/in/fibroblasts"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"},{"id":4045206,"name":"Collagen type I","url":"https://www.academia.edu/Documents/in/Collagen_type_I"}],"urls":[{"id":23312378,"url":"https://www.ahajournals.org/doi/full/10.1161/01.RES.0000207384.81818.d4"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="50021670"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/50021670/Regulation_of_Myocardium_Formation_after_the_Initial_Development_of_the_Linear_Heart_Tube"><img alt="Research paper thumbnail of Regulation of Myocardium Formation after the Initial Development of the Linear Heart Tube" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/50021670/Regulation_of_Myocardium_Formation_after_the_Initial_Development_of_the_Linear_Heart_Tube">Regulation of Myocardium Formation after the Initial Development of the Linear Heart Tube</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AMoorman1">A. Moorman</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RogerMarkwald">Roger Markwald</a></span></div><div class="wp-workCard_item"><span>Cardiovascular Development and Congenital Malformations</span><span>, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="50021670"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="50021670"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 50021670; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=50021670]").text(description); $(".js-view-count[data-work-id=50021670]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 50021670; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='50021670']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 50021670, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=50021670]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":50021670,"title":"Regulation of Myocardium Formation after the Initial Development of the Linear Heart Tube","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2005,"errors":{}},"publication_name":"Cardiovascular Development and Congenital Malformations"},"translated_abstract":null,"internal_url":"https://www.academia.edu/50021670/Regulation_of_Myocardium_Formation_after_the_Initial_Development_of_the_Linear_Heart_Tube","translated_internal_url":"","created_at":"2021-07-17T10:14:15.710-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":46673754,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":38416531,"work_id":50021670,"tagging_user_id":46673754,"tagged_user_id":46881112,"co_author_invite_id":null,"email":"m***f@amc.nl","affiliation":"Academic Medical Centre/ Universiteit van Amsterdam","display_order":0,"name":"Maurice Van Den Hoff","title":"Regulation of Myocardium Formation after the Initial Development of the Linear Heart Tube"},{"id":38416533,"work_id":50021670,"tagging_user_id":46673754,"tagged_user_id":null,"co_author_invite_id":774572,"email":"b***f@lumc.nl","display_order":6291456,"name":"Boudewijn Kruithof","title":"Regulation of Myocardium Formation after the Initial Development of the Linear Heart Tube"},{"id":38416536,"work_id":50021670,"tagging_user_id":46673754,"tagged_user_id":null,"co_author_invite_id":3292114,"email":"w***a@musc.edu","display_order":7340032,"name":"Andy Wessels","title":"Regulation of Myocardium Formation after the Initial Development of the Linear Heart Tube"},{"id":38416537,"work_id":50021670,"tagging_user_id":46673754,"tagged_user_id":38217099,"co_author_invite_id":null,"email":"m***d@musc.edu","display_order":7864320,"name":"Roger Markwald","title":"Regulation of Myocardium Formation after the Initial Development of the Linear Heart Tube"}],"downloadable_attachments":[],"slug":"Regulation_of_Myocardium_Formation_after_the_Initial_Development_of_the_Linear_Heart_Tube","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":46673754,"first_name":"A.","middle_initials":null,"last_name":"Moorman","page_name":"AMoorman1","domain_name":"independent","created_at":"2016-04-08T13:27:11.512-07:00","display_name":"A. Moorman","url":"https://independent.academia.edu/AMoorman1"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="80012400"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/80012400/Periostin_regulates_collagen_fibrillogenesis_and_the_biomechanical_properties_of_connective_tissues"><img alt="Research paper thumbnail of Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues" class="work-thumbnail" src="https://attachments.academia-assets.com/86535526/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/80012400/Periostin_regulates_collagen_fibrillogenesis_and_the_biomechanical_properties_of_connective_tissues">Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues</a></div><div class="wp-workCard_item"><span>Journal of Cellular Biochemistry</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b7549c4733e7fabbef44fc154e4df7ee" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86535526,"asset_id":80012400,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86535526/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="80012400"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="80012400"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80012400; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=80012400]").text(description); $(".js-view-count[data-work-id=80012400]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 80012400; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='80012400']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 80012400, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b7549c4733e7fabbef44fc154e4df7ee" } } $('.js-work-strip[data-work-id=80012400]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":80012400,"title":"Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues","translated_title":"","metadata":{"publisher":"Wiley","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Journal of Cellular Biochemistry"},"translated_abstract":null,"internal_url":"https://www.academia.edu/80012400/Periostin_regulates_collagen_fibrillogenesis_and_the_biomechanical_properties_of_connective_tissues","translated_internal_url":"","created_at":"2022-05-26T22:27:28.997-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":86535526,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86535526/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/86535526/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Periostin_regulates_collagen_fibrillogen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86535526/ptpmcrender-libre.pdf?1653629819=\u0026response-content-disposition=attachment%3B+filename%3DPeriostin_regulates_collagen_fibrillogen.pdf\u0026Expires=1732499583\u0026Signature=I6YI8XYiuGrUBsuXtU4rv1C4PrE1YUOjhWa93Wnvhk-LJfEcWlMzQfYWMMFW4lw0OymX1RIHCZN8zlwP~tC~Vs-ijMySNqfptKV66Pc7oU70grZ0UD0pW82pqUHTTqYAkVf7Zf4H-YE36DOvrmbYhEe6-0GNEyKd1wH3f4evyMjqh81QqGRZFr2rDYCUjmUN5jxgb~mBzHJtW6UI-X3HcGZGMG~BqPR3UZ-kUcSL3AD~G7Z7KrlYnByjzPl3HoogSZptXmXLsvcN7ei2dURxTetOgVXMtOjeJmjWWooaJcUcUx0J~rajKFduCw19YcBJHB8AV8SQ8m61XsWhNZe3QA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Periostin_regulates_collagen_fibrillogenesis_and_the_biomechanical_properties_of_connective_tissues","translated_slug":"","page_count":25,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":86535526,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86535526/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/86535526/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Periostin_regulates_collagen_fibrillogen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86535526/ptpmcrender-libre.pdf?1653629819=\u0026response-content-disposition=attachment%3B+filename%3DPeriostin_regulates_collagen_fibrillogen.pdf\u0026Expires=1732499583\u0026Signature=I6YI8XYiuGrUBsuXtU4rv1C4PrE1YUOjhWa93Wnvhk-LJfEcWlMzQfYWMMFW4lw0OymX1RIHCZN8zlwP~tC~Vs-ijMySNqfptKV66Pc7oU70grZ0UD0pW82pqUHTTqYAkVf7Zf4H-YE36DOvrmbYhEe6-0GNEyKd1wH3f4evyMjqh81QqGRZFr2rDYCUjmUN5jxgb~mBzHJtW6UI-X3HcGZGMG~BqPR3UZ-kUcSL3AD~G7Z7KrlYnByjzPl3HoogSZptXmXLsvcN7ei2dURxTetOgVXMtOjeJmjWWooaJcUcUx0J~rajKFduCw19YcBJHB8AV8SQ8m61XsWhNZe3QA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":29149,"name":"Extracellular Matrix","url":"https://www.academia.edu/Documents/in/Extracellular_Matrix"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":60915,"name":"Cellular","url":"https://www.academia.edu/Documents/in/Cellular"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":78753,"name":"Differential scanning calorimetry","url":"https://www.academia.edu/Documents/in/Differential_scanning_calorimetry"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":129474,"name":"Connective tissue","url":"https://www.academia.edu/Documents/in/Connective_tissue"},{"id":216699,"name":"Immunoprecipitation","url":"https://www.academia.edu/Documents/in/Immunoprecipitation"},{"id":402759,"name":"Chickens","url":"https://www.academia.edu/Documents/in/Chickens"},{"id":851448,"name":"Fibrillogenesis","url":"https://www.academia.edu/Documents/in/Fibrillogenesis"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":1824499,"name":"Cell Adhesion Molecules","url":"https://www.academia.edu/Documents/in/Cell_Adhesion_Molecules"},{"id":1902100,"name":"Biomechanical Phenomena","url":"https://www.academia.edu/Documents/in/Biomechanical_Phenomena"},{"id":3675689,"name":"Chick embryo","url":"https://www.academia.edu/Documents/in/Chick_embryo"},{"id":4045206,"name":"Collagen type I","url":"https://www.academia.edu/Documents/in/Collagen_type_I"}],"urls":[{"id":20814595,"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjcb.21224"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="80012393"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/80012393/Periostin_regulates_collagen_fibrillogenesis_and_the_biomechanical_properties_of_connective_tissues"><img alt="Research paper thumbnail of Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues" class="work-thumbnail" src="https://attachments.academia-assets.com/86535527/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/80012393/Periostin_regulates_collagen_fibrillogenesis_and_the_biomechanical_properties_of_connective_tissues">Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues</a></div><div class="wp-workCard_item"><span>Journal of Cellular Biochemistry</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9118e2d4a0a35d1c673f9aae7d9bb856" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86535527,"asset_id":80012393,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86535527/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="80012393"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="80012393"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80012393; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=80012393]").text(description); $(".js-view-count[data-work-id=80012393]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 80012393; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='80012393']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 80012393, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9118e2d4a0a35d1c673f9aae7d9bb856" } } $('.js-work-strip[data-work-id=80012393]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":80012393,"title":"Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues","translated_title":"","metadata":{"publisher":"Wiley","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Journal of Cellular Biochemistry"},"translated_abstract":null,"internal_url":"https://www.academia.edu/80012393/Periostin_regulates_collagen_fibrillogenesis_and_the_biomechanical_properties_of_connective_tissues","translated_internal_url":"","created_at":"2022-05-26T22:27:19.881-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38217099,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":86535527,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86535527/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/86535527/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Periostin_regulates_collagen_fibrillogen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86535527/ptpmcrender-libre.pdf?1653629819=\u0026response-content-disposition=attachment%3B+filename%3DPeriostin_regulates_collagen_fibrillogen.pdf\u0026Expires=1732499583\u0026Signature=clJZoFG7aEQ2QQPcVZ8IPRQ7Knumeqapn6wUAUQT8dnp5a5ebr1tAk9z-WyKiAuUDoL3VbGgee6~AiQ9Bs3cUeRYnTkR61RZrhMr4mQEz5AAM9LKvw0WoSoN69W2uQZQE0v0EA~pE9LUgPXTJaIntCUqy6dM5mn~7eJKJ-mnw9uFq-pS-~4~2v0KnzWRvLDjkaVz92jyyrGFJwWdAUAg8TohOhE7lPBpcG0bgC3JkECbJtlOkjLIor9N-ipXBo75Gr4sj3-zwOwn6fdkiAxZP2XvtP-JUvtmahxopHJxZWHmdA5OreOURTio4086Lf~kx1DVhAppwKH6YPIFzkrO0Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Periostin_regulates_collagen_fibrillogenesis_and_the_biomechanical_properties_of_connective_tissues","translated_slug":"","page_count":25,"language":"en","content_type":"Work","owner":{"id":38217099,"first_name":"Roger","middle_initials":"","last_name":"Markwald","page_name":"RogerMarkwald","domain_name":"independent","created_at":"2015-11-12T14:06:22.166-08:00","display_name":"Roger Markwald","url":"https://independent.academia.edu/RogerMarkwald"},"attachments":[{"id":86535527,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86535527/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/86535527/download_file?st=MTczMjQ5OTk1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Periostin_regulates_collagen_fibrillogen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86535527/ptpmcrender-libre.pdf?1653629819=\u0026response-content-disposition=attachment%3B+filename%3DPeriostin_regulates_collagen_fibrillogen.pdf\u0026Expires=1732499583\u0026Signature=clJZoFG7aEQ2QQPcVZ8IPRQ7Knumeqapn6wUAUQT8dnp5a5ebr1tAk9z-WyKiAuUDoL3VbGgee6~AiQ9Bs3cUeRYnTkR61RZrhMr4mQEz5AAM9LKvw0WoSoN69W2uQZQE0v0EA~pE9LUgPXTJaIntCUqy6dM5mn~7eJKJ-mnw9uFq-pS-~4~2v0KnzWRvLDjkaVz92jyyrGFJwWdAUAg8TohOhE7lPBpcG0bgC3JkECbJtlOkjLIor9N-ipXBo75Gr4sj3-zwOwn6fdkiAxZP2XvtP-JUvtmahxopHJxZWHmdA5OreOURTio4086Lf~kx1DVhAppwKH6YPIFzkrO0Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":29149,"name":"Extracellular Matrix","url":"https://www.academia.edu/Documents/in/Extracellular_Matrix"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":60915,"name":"Cellular","url":"https://www.academia.edu/Documents/in/Cellular"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":78753,"name":"Differential scanning calorimetry","url":"https://www.academia.edu/Documents/in/Differential_scanning_calorimetry"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":129474,"name":"Connective tissue","url":"https://www.academia.edu/Documents/in/Connective_tissue"},{"id":216699,"name":"Immunoprecipitation","url":"https://www.academia.edu/Documents/in/Immunoprecipitation"},{"id":402759,"name":"Chickens","url":"https://www.academia.edu/Documents/in/Chickens"},{"id":851448,"name":"Fibrillogenesis","url":"https://www.academia.edu/Documents/in/Fibrillogenesis"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":1824499,"name":"Cell Adhesion Molecules","url":"https://www.academia.edu/Documents/in/Cell_Adhesion_Molecules"},{"id":1902100,"name":"Biomechanical Phenomena","url":"https://www.academia.edu/Documents/in/Biomechanical_Phenomena"},{"id":3675689,"name":"Chick embryo","url":"https://www.academia.edu/Documents/in/Chick_embryo"},{"id":4045206,"name":"Collagen type I","url":"https://www.academia.edu/Documents/in/Collagen_type_I"}],"urls":[{"id":20814593,"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjcb.21224"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/google_contacts-0dfb882d836b94dbcb4a2d123d6933fc9533eda5be911641f20b4eb428429600.js"], function() { // from javascript_helper.rb $('.js-google-connect-button').click(function(e) { e.preventDefault(); GoogleContacts.authorize_and_show_contacts(); Aedu.Dismissibles.recordClickthrough("WowProfileImportContactsPrompt"); }); $('.js-update-biography-button').click(function(e) { e.preventDefault(); Aedu.Dismissibles.recordClickthrough("UpdateUserBiographyPrompt"); $.ajax({ url: $r.api_v0_profiles_update_about_path({ subdomain_param: 'api', about: "", }), type: 'PUT', success: function(response) { location.reload(); } }); }); $('.js-work-creator-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_document_path({ source: encodeURIComponent(""), }); }); $('.js-video-upload-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_video_path({ source: encodeURIComponent(""), }); }); $('.js-do-this-later-button').click(function() { $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("WowProfileImportContactsPrompt"); }); $('.js-update-biography-do-this-later-button').click(function(){ $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("UpdateUserBiographyPrompt"); }); $('.wow-profile-mentions-upsell--close').click(function(){ $('.wow-profile-mentions-upsell--panel').hide(); Aedu.Dismissibles.recordDismissal("WowProfileMentionsUpsell"); }); $('.wow-profile-mentions-upsell--button').click(function(){ Aedu.Dismissibles.recordClickthrough("WowProfileMentionsUpsell"); }); new WowProfile.SocialRedesignUserWorks({ initialWorksOffset: 20, allWorksOffset: 20, maxSections: 1 }) }); </script> </div></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile_edit-5ea339ee107c863779f560dd7275595239fed73f1a13d279d2b599a28c0ecd33.js","https://a.academia-assets.com/assets/add_coauthor-22174b608f9cb871d03443cafa7feac496fb50d7df2d66a53f5ee3c04ba67f53.js","https://a.academia-assets.com/assets/tab-dcac0130902f0cc2d8cb403714dd47454f11fc6fb0e99ae6a0827b06613abc20.js","https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js"], function() { // from javascript_helper.rb window.ae = window.ae || {}; window.ae.WowProfile = window.ae.WowProfile || {}; if(Aedu.User.current && Aedu.User.current.id === $viewedUser.id) { window.ae.WowProfile.current_user_edit = {}; new WowProfileEdit.EditUploadView({ el: '.js-edit-upload-button-wrapper', model: window.$current_user, }); new AddCoauthor.AddCoauthorsController(); } var userInfoView = new WowProfile.SocialRedesignUserInfo({ recaptcha_key: "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB" }); WowProfile.router = new WowProfile.Router({ userInfoView: userInfoView }); Backbone.history.start({ pushState: true, root: "/" + $viewedUser.page_name }); new WowProfile.UserWorksNav() }); </script> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "b2d744394e7e0f5e7e4e43afecf529d8c5239deebf4ae2e602f142582a61b21f", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="wvNTkr5Ngrx4xsJt6JmemNANLS+7zgDSm8ovtHfLDSBoOxb041tmkgakGBiE+WDojh1BBRHqfjB+nEBcRTcNbQ==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://independent.academia.edu/RogerMarkwald" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="+mGY0UXKWk12gyThMIndOo6c076Cd57sZLS/6RN7xw1Qqd23GNy+Ywjh/pRc6SNK0Iy/lChT4A6B4tABIYfHQA==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style="width:100%;"><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a rel="nofollow" href="https://medium.com/academia">Blog</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style="width:100%;"><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>