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overflow: hidden; text-overflow: ellipsis; -webkit-line-clamp: 3; -webkit-box-orient: vertical; }</style><div class="col-xs-12 clearfix"><div class="u-floatLeft"><h1 class="PageHeader-title u-m0x u-fs30">Anticancer activity</h1><div class="u-tcGrayDark">19 Followers</div><div class="u-tcGrayDark u-mt2x">Recent papers in <b>Anticancer activity</b></div></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline u-displayFlex"><li class="active"><a href="https://www.academia.edu/Documents/in/Anticancer_activity">Top Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Anticancer_activity/MostCited">Most Cited Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Anticancer_activity/MostDownloaded">Most Downloaded Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Anticancer_activity/MostRecent">Newest Papers</a></li><li><a class="" href="https://www.academia.edu/People/Anticancer_activity">People</a></li></ul></div><style type="text/css">ul.nav{flex-direction:row}@media(max-width: 567px){ul.nav{flex-direction:column}.TabbedNavigation li{max-width:100%}.TabbedNavigation li.active{background-color:var(--background-grey, #dddde2)}.TabbedNavigation li.active:before,.TabbedNavigation li.active:after{display:none}}</style></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_75699378" data-work_id="75699378" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/75699378/Anticancer_Activity_of_New_Copper_II_Complexes_with_6_Thiguanine_Drug">Anticancer Activity of New Copper (II) Complexes with 6-Thiguanine Drug</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A new complex has been synthesized of Cu (II) complex with 6-thioguanine and phyico-chemical characterized by amperometry, polarography elemental analysis and FTIR spectroscopy. After Synthesis of metal complex, it was evaluated it for... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_75699378" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A new complex has been synthesized of Cu (II) complex with 6-thioguanine and phyico-chemical characterized by amperometry, polarography elemental analysis and FTIR spectroscopy. After Synthesis of metal complex, it was evaluated it for antibacterial and antifungal activities against various pathogenic microorganisms such as; Streptococcus aureus, Proteus. M., klebsiella pneumonia and Asperginus niger, Nigrosporan S.P. B16-F10 melanoma cell and C-57BL/6 mice has been used for anticancer screening of metal complex for in vitro and in vivo study. The result of pharmacological studies with M: L revealed that the complex is more potent as compared to the pure drug as regards to its anticancer activity.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/75699378" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d7ea959b11546892e891b88445f12005" rel="nofollow" data-download="{"attachment_id":83365621,"asset_id":75699378,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/83365621/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="211349963" href="https://independent.academia.edu/lifescienceglobal">Lifescience Global Canada</a><script data-card-contents-for-user="211349963" type="text/json">{"id":211349963,"first_name":"Lifescience","last_name":"Global Canada","domain_name":"independent","page_name":"lifescienceglobal","display_name":"Lifescience Global Canada","profile_url":"https://independent.academia.edu/lifescienceglobal?f_ri=2018875","photo":"https://0.academia-photos.com/211349963/71416544/59860660/s65_lifescience.global_canada.jpg"}</script></span></span></li><li class="js-paper-rank-work_75699378 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="75699378"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 75699378, container: ".js-paper-rank-work_75699378", }); 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$(".js-view-count[data-work-id=75699378]").text(description); $(".js-view-count-work_75699378").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_75699378").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="75699378"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="27868" rel="nofollow" href="https://www.academia.edu/Documents/in/Polarography">Polarography</a>, <script data-card-contents-for-ri="27868" type="text/json">{"id":27868,"name":"Polarography","url":"https://www.academia.edu/Documents/in/Polarography?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="881158" rel="nofollow" href="https://www.academia.edu/Documents/in/Biological_investigations">Biological investigations</a>, <script data-card-contents-for-ri="881158" type="text/json">{"id":881158,"name":"Biological investigations","url":"https://www.academia.edu/Documents/in/Biological_investigations?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="1603130" rel="nofollow" href="https://www.academia.edu/Documents/in/Amperometry">Amperometry</a>, <script data-card-contents-for-ri="1603130" type="text/json">{"id":1603130,"name":"Amperometry","url":"https://www.academia.edu/Documents/in/Amperometry?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2018875" rel="nofollow" href="https://www.academia.edu/Documents/in/Anticancer_activity">Anticancer activity</a><script data-card-contents-for-ri="2018875" type="text/json">{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=75699378]'), work: {"id":75699378,"title":"Anticancer Activity of New Copper (II) Complexes with 6-Thiguanine Drug","created_at":"2022-04-07T01:37:45.060-07:00","url":"https://www.academia.edu/75699378/Anticancer_Activity_of_New_Copper_II_Complexes_with_6_Thiguanine_Drug?f_ri=2018875","dom_id":"work_75699378","summary":"A new complex has been synthesized of Cu (II) complex with 6-thioguanine and phyico-chemical characterized by amperometry, polarography elemental analysis and FTIR spectroscopy. After Synthesis of metal complex, it was evaluated it for antibacterial and antifungal activities against various pathogenic microorganisms such as; Streptococcus aureus, Proteus. M., klebsiella pneumonia and Asperginus niger, Nigrosporan S.P. B16-F10 melanoma cell and C-57BL/6 mice has been used for anticancer screening of metal complex for in vitro and in vivo study. The result of pharmacological studies with M: L revealed that the complex is more potent as compared to the pure drug as regards to its anticancer activity.","downloadable_attachments":[{"id":83365621,"asset_id":75699378,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":211349963,"first_name":"Lifescience","last_name":"Global Canada","domain_name":"independent","page_name":"lifescienceglobal","display_name":"Lifescience Global Canada","profile_url":"https://independent.academia.edu/lifescienceglobal?f_ri=2018875","photo":"https://0.academia-photos.com/211349963/71416544/59860660/s65_lifescience.global_canada.jpg"}],"research_interests":[{"id":27868,"name":"Polarography","url":"https://www.academia.edu/Documents/in/Polarography?f_ri=2018875","nofollow":true},{"id":881158,"name":"Biological investigations","url":"https://www.academia.edu/Documents/in/Biological_investigations?f_ri=2018875","nofollow":true},{"id":1603130,"name":"Amperometry","url":"https://www.academia.edu/Documents/in/Amperometry?f_ri=2018875","nofollow":true},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_75914114" data-work_id="75914114" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/75914114/Pectinas_modificadas_con_actividad_contra_el_c%C3%A1ncer_de_colon_Una_revisi%C3%B3n_sistem%C3%A1tica_de_2010_2021">Pectinas modificadas con actividad contra el cáncer de colon: Una revisión sistemática de 2010-2021</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Context: Colon cancer is a serious disease that can be hereditary or arise from exposure to carcinogens in unhealthy food. Current chemotherapy treatment has serious cardiovascular adverse effects, is not always effective, and there may... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_75914114" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Context: Colon cancer is a serious disease that can be hereditary or arise from exposure to carcinogens in unhealthy food. Current chemotherapy treatment has serious cardiovascular adverse effects, is not always effective, and there may be resistance to treatment. Recently, studies have found an optimal anticancer activity of modified pectins on colon cancer. Aims: To systematically review the scientific literature, with PRISMA guidelines, of the articles found in the last 11 years, on the potential anticancer effects of pectins on colon cancer. Methods: PRISMA and Rayyan were used for the selection of studies and a standardized search was followed in four databases with the terms: modified pectins, cancer, therapy. Data extraction was performed using Excel and relevant information on anticancer activity was collected. Results: In total, 16 articles were included, finding seven in vitro, three mixed and six in vivo studies. The anticancer activity and optimization of the formulation, encapsulation, release of pectin-based drugs were evaluated by different methods in 12 and six articles, respectively. Most of the studies were classified as high quality with the AXIS tool. Furthermore, 11 out of 12 articles showed positive effects of modified pectins on colon cancer both in vivo and in vitro and six out of six articles found positive effects on pectin-based formulations. Conclusions: The evidence found suggests a beneficial effect of modified pectins on colon cancer, however, more in vivo studies are required.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/75914114" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4c4c54b614c696c48d654a68d486214f" rel="nofollow" data-download="{"attachment_id":83578896,"asset_id":75914114,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/83578896/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="2831786" href="https://ucn.academia.edu/GabinoGarrido">Gabino Garrido</a><script data-card-contents-for-user="2831786" type="text/json">{"id":2831786,"first_name":"Gabino","last_name":"Garrido","domain_name":"ucn","page_name":"GabinoGarrido","display_name":"Gabino Garrido","profile_url":"https://ucn.academia.edu/GabinoGarrido?f_ri=2018875","photo":"https://0.academia-photos.com/2831786/927225/4491672/s65_gabino.garrido.jpg"}</script></span></span></li><li class="js-paper-rank-work_75914114 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="75914114"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 75914114, container: ".js-paper-rank-work_75914114", }); 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$(".js-view-count[data-work-id=75914114]").text(description); $(".js-view-count-work_75914114").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_75914114").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="75914114"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6021" rel="nofollow" href="https://www.academia.edu/Documents/in/Cancer">Cancer</a>, <script data-card-contents-for-ri="6021" type="text/json">{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6482" rel="nofollow" href="https://www.academia.edu/Documents/in/Meta-Analysis_and_Systematic_Review">Meta-Analysis and Systematic Review</a>, <script data-card-contents-for-ri="6482" type="text/json">{"id":6482,"name":"Meta-Analysis and Systematic Review","url":"https://www.academia.edu/Documents/in/Meta-Analysis_and_Systematic_Review?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="8656" rel="nofollow" href="https://www.academia.edu/Documents/in/Schema_therapy">Schema therapy</a>, <script data-card-contents-for-ri="8656" type="text/json">{"id":8656,"name":"Schema therapy","url":"https://www.academia.edu/Documents/in/Schema_therapy?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22255" rel="nofollow" href="https://www.academia.edu/Documents/in/Cancer_Research">Cancer Research</a><script data-card-contents-for-ri="22255" type="text/json">{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=75914114]'), work: {"id":75914114,"title":"Pectinas modificadas con actividad contra el cáncer de colon: Una revisión sistemática de 2010-2021","created_at":"2022-04-09T07:38:03.798-07:00","url":"https://www.academia.edu/75914114/Pectinas_modificadas_con_actividad_contra_el_c%C3%A1ncer_de_colon_Una_revisi%C3%B3n_sistem%C3%A1tica_de_2010_2021?f_ri=2018875","dom_id":"work_75914114","summary":"Context: Colon cancer is a serious disease that can be hereditary or arise from exposure to carcinogens in unhealthy food. Current chemotherapy treatment has serious cardiovascular adverse effects, is not always effective, and there may be resistance to treatment. Recently, studies have found an optimal anticancer activity of modified pectins on colon cancer. Aims: To systematically review the scientific literature, with PRISMA guidelines, of the articles found in the last 11 years, on the potential anticancer effects of pectins on colon cancer. Methods: PRISMA and Rayyan were used for the selection of studies and a standardized search was followed in four databases with the terms: modified pectins, cancer, therapy. Data extraction was performed using Excel and relevant information on anticancer activity was collected. Results: In total, 16 articles were included, finding seven in vitro, three mixed and six in vivo studies. The anticancer activity and optimization of the formulation, encapsulation, release of pectin-based drugs were evaluated by different methods in 12 and six articles, respectively. Most of the studies were classified as high quality with the AXIS tool. Furthermore, 11 out of 12 articles showed positive effects of modified pectins on colon cancer both in vivo and in vitro and six out of six articles found positive effects on pectin-based formulations. Conclusions: The evidence found suggests a beneficial effect of modified pectins on colon cancer, however, more in vivo studies are required.","downloadable_attachments":[{"id":83578896,"asset_id":75914114,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":2831786,"first_name":"Gabino","last_name":"Garrido","domain_name":"ucn","page_name":"GabinoGarrido","display_name":"Gabino Garrido","profile_url":"https://ucn.academia.edu/GabinoGarrido?f_ri=2018875","photo":"https://0.academia-photos.com/2831786/927225/4491672/s65_gabino.garrido.jpg"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=2018875","nofollow":true},{"id":6482,"name":"Meta-Analysis and Systematic Review","url":"https://www.academia.edu/Documents/in/Meta-Analysis_and_Systematic_Review?f_ri=2018875","nofollow":true},{"id":8656,"name":"Schema therapy","url":"https://www.academia.edu/Documents/in/Schema_therapy?f_ri=2018875","nofollow":true},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research?f_ri=2018875","nofollow":true},{"id":44348,"name":"Systematic Reviews","url":"https://www.academia.edu/Documents/in/Systematic_Reviews?f_ri=2018875"},{"id":66683,"name":"Systematic Literature Review","url":"https://www.academia.edu/Documents/in/Systematic_Literature_Review?f_ri=2018875"},{"id":216684,"name":"Modified citrus pectin","url":"https://www.academia.edu/Documents/in/Modified_citrus_pectin?f_ri=2018875"},{"id":221411,"name":"Systematic review","url":"https://www.academia.edu/Documents/in/Systematic_review?f_ri=2018875"},{"id":405347,"name":"Pharmaceutical Formulation Technology","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Formulation_Technology?f_ri=2018875"},{"id":420802,"name":"Colon cancer","url":"https://www.academia.edu/Documents/in/Colon_cancer?f_ri=2018875"},{"id":503922,"name":"Antioxidant and Anticancer activity","url":"https://www.academia.edu/Documents/in/Antioxidant_and_Anticancer_activity?f_ri=2018875"},{"id":603681,"name":"Formulation development","url":"https://www.academia.edu/Documents/in/Formulation_development?f_ri=2018875"},{"id":670901,"name":"Pectin","url":"https://www.academia.edu/Documents/in/Pectin?f_ri=2018875"},{"id":794479,"name":"Prevention of Colon Cancer","url":"https://www.academia.edu/Documents/in/Prevention_of_Colon_Cancer?f_ri=2018875"},{"id":1390077,"name":"PRISMA","url":"https://www.academia.edu/Documents/in/PRISMA?f_ri=2018875"},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_35150631" data-work_id="35150631" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/35150631/Apoptosis_Induction_by_Cestrum_parqui_LH%C3%A9r_leaves_on_HL_60_Cell_Line_Identification_of_Active_Phytomolecules">Apoptosis Induction by Cestrum parqui L'Hér. leaves on HL-60 Cell Line: Identification of Active Phytomolecules</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: In our time, there is an urgent need to discover natural anticancer products without toxic side’s effects. Objective: The present study was conducted to investigate the anticancer activity of the methanolic extract of Cestrum... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_35150631" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: In our time, there is an urgent need to discover natural anticancer products without toxic side’s effects.<br />Objective: The present study was conducted to investigate the  anticancer activity of the methanolic extract of Cestrum parqui leaves as well as identification of the active compounds in this concern.<br />Materials and Methods: Eight column chromatographic fractions were tested against human leukaemia cell line (HL-60) and the cell viability was measured by dimethylthiazol tetrazolium assay. Studies of apoptosis, cell cycle and DNA fragmentation were carried out following the standard protocol. Effective fractions were analysed by high performance liquid chromatography-ultra violet, HPLC-evaporative light scattering detector and preparative-HPLC. Finally the active compounds were identified by gas chromatography coupled to mass spectrometry.<br />Results: Out of eight, fraction II showed remarkable inhibition on the growth of HL-60 cell line and fraction I showed moderate activity on such inhibition. Mechanisms of the inhibition were identified as cell cycle arrestation and apoptosis induction by the said fractions. Chromatographic and mass spectrometric analysis of the fraction II indicated the presence of oleanolic and ursolic acids as biologically active compounds.<br />Conclusion: This study is the first investigation that shows Cestrum parqui has anticancer activity and the responsible compounds are oleanolic and ursolic acids which may be used for chemotherapy of certain cancer in future after extensive work in this line.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/35150631" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="01492f03738e02b27c89939e139d04b1" rel="nofollow" data-download="{"attachment_id":55012413,"asset_id":35150631,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/55012413/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33657132" href="https://independent.academia.edu/InternationalJournalofCancerStudiesResearchIJCR">International Journal of Cancer Studies & Research (IJCR)</a><script data-card-contents-for-user="33657132" type="text/json">{"id":33657132,"first_name":"International Journal of Cancer","last_name":"Studies \u0026 Research (IJCR)","domain_name":"independent","page_name":"InternationalJournalofCancerStudiesResearchIJCR","display_name":"International Journal of Cancer Studies \u0026 Research (IJCR)","profile_url":"https://independent.academia.edu/InternationalJournalofCancerStudiesResearchIJCR?f_ri=2018875","photo":"https://0.academia-photos.com/33657132/9923925/11064728/s65_international_journal_of_cancer.studies_research_ijcr_.jpg"}</script></span></span></li><li class="js-paper-rank-work_35150631 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="35150631"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 35150631, container: ".js-paper-rank-work_35150631", }); 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$(".js-view-count[data-work-id=35150631]").text(description); $(".js-view-count-work_35150631").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_35150631").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="35150631"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="67648" rel="nofollow" href="https://www.academia.edu/Documents/in/GC-MS">GC-MS</a>, <script data-card-contents-for-ri="67648" type="text/json">{"id":67648,"name":"GC-MS","url":"https://www.academia.edu/Documents/in/GC-MS?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2018875" rel="nofollow" href="https://www.academia.edu/Documents/in/Anticancer_activity">Anticancer activity</a><script data-card-contents-for-ri="2018875" type="text/json">{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=35150631]'), work: {"id":35150631,"title":"Apoptosis Induction by Cestrum parqui L'Hér. leaves on HL-60 Cell Line: Identification of Active Phytomolecules","created_at":"2017-11-15T00:52:26.355-08:00","url":"https://www.academia.edu/35150631/Apoptosis_Induction_by_Cestrum_parqui_LH%C3%A9r_leaves_on_HL_60_Cell_Line_Identification_of_Active_Phytomolecules?f_ri=2018875","dom_id":"work_35150631","summary":"Background: In our time, there is an urgent need to discover natural anticancer products without toxic side’s effects.\nObjective: The present study was conducted to investigate the anticancer activity of the methanolic extract of Cestrum parqui leaves as well as identification of the active compounds in this concern.\nMaterials and Methods: Eight column chromatographic fractions were tested against human leukaemia cell line (HL-60) and the cell viability was measured by dimethylthiazol tetrazolium assay. Studies of apoptosis, cell cycle and DNA fragmentation were carried out following the standard protocol. Effective fractions were analysed by high performance liquid chromatography-ultra violet, HPLC-evaporative light scattering detector and preparative-HPLC. Finally the active compounds were identified by gas chromatography coupled to mass spectrometry.\nResults: Out of eight, fraction II showed remarkable inhibition on the growth of HL-60 cell line and fraction I showed moderate activity on such inhibition. Mechanisms of the inhibition were identified as cell cycle arrestation and apoptosis induction by the said fractions. Chromatographic and mass spectrometric analysis of the fraction II indicated the presence of oleanolic and ursolic acids as biologically active compounds.\nConclusion: This study is the first investigation that shows Cestrum parqui has anticancer activity and the responsible compounds are oleanolic and ursolic acids which may be used for chemotherapy of certain cancer in future after extensive work in this line.","downloadable_attachments":[{"id":55012413,"asset_id":35150631,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33657132,"first_name":"International Journal of Cancer","last_name":"Studies \u0026 Research (IJCR)","domain_name":"independent","page_name":"InternationalJournalofCancerStudiesResearchIJCR","display_name":"International Journal of Cancer Studies \u0026 Research (IJCR)","profile_url":"https://independent.academia.edu/InternationalJournalofCancerStudiesResearchIJCR?f_ri=2018875","photo":"https://0.academia-photos.com/33657132/9923925/11064728/s65_international_journal_of_cancer.studies_research_ijcr_.jpg"}],"research_interests":[{"id":67648,"name":"GC-MS","url":"https://www.academia.edu/Documents/in/GC-MS?f_ri=2018875","nofollow":true},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_43897420" data-work_id="43897420" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/43897420/EVALUATION_OF_SOME_CHEMICAL_CONSTITUENTS_ANTIOXIDANT_ANTIBACTERIAL_AND_ANTICANCER_ACTIVITIES_OF_BETA_VULGARIS_L_ROOT">EVALUATION OF SOME CHEMICAL CONSTITUENTS, ANTIOXIDANT, ANTIBACTERIAL AND ANTICANCER ACTIVITIES OF BETA VULGARIS L. ROOT</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Beta vulgaris is belonging to the family Che-nopodiaceae and has several varieties with bulb colors ranging from yellow to red. Deep red-colored beet roots are the most popular for human consumption, both cooked and raw as salad or juice.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_43897420" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Beta vulgaris is belonging to the family Che-nopodiaceae and has several varieties with bulb colors ranging from yellow to red. Deep red-colored beet roots are the most popular for human consumption, both cooked and raw as salad or juice. The ethanolic extract of beetroots contains valuable and active compounds such as carotenoids, phenols, flavonoids, tannin, alkaloids, vitamins C, B3, B6 and B9. Therefore, beetroot extract has antioxidant and antimicrobial activity against gram positive and negative bacteria. Gram-positive bacteria Staphylococcus aureus and Bacillus cereus demonstrated higher susceptibility than Gram-negative Escherichia coli and Pseudomonas typhi-mureum. Beta vulgaris ethanolic extract exhibit significant anticancer activity against lung (A549) but slight effect against colorectal adenocarcinoma Caco-2 cell lines at the high concentrations of etha-nolic extract (800 µg/ml).</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/43897420" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="572811c2e146f073dbf2043ab1fc5cd8" rel="nofollow" data-download="{"attachment_id":64220645,"asset_id":43897420,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/64220645/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33397819" href="https://cambridge.academia.edu/GehanSafwat">Gehan Safwat</a><script data-card-contents-for-user="33397819" type="text/json">{"id":33397819,"first_name":"Gehan","last_name":"Safwat","domain_name":"cambridge","page_name":"GehanSafwat","display_name":"Gehan Safwat","profile_url":"https://cambridge.academia.edu/GehanSafwat?f_ri=2018875","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_43897420 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="43897420"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 43897420, container: ".js-paper-rank-work_43897420", }); 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$(".js-view-count[data-work-id=43897420]").text(description); $(".js-view-count-work_43897420").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_43897420").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="43897420"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="22052" rel="nofollow" href="https://www.academia.edu/Documents/in/Flavonoids">Flavonoids</a>, <script data-card-contents-for-ri="22052" type="text/json">{"id":22052,"name":"Flavonoids","url":"https://www.academia.edu/Documents/in/Flavonoids?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22053" rel="nofollow" href="https://www.academia.edu/Documents/in/Carotenoids">Carotenoids</a>, <script data-card-contents-for-ri="22053" type="text/json">{"id":22053,"name":"Carotenoids","url":"https://www.academia.edu/Documents/in/Carotenoids?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="347988" rel="nofollow" href="https://www.academia.edu/Documents/in/Phenols">Phenols</a>, <script data-card-contents-for-ri="347988" type="text/json">{"id":347988,"name":"Phenols","url":"https://www.academia.edu/Documents/in/Phenols?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="382472" rel="nofollow" href="https://www.academia.edu/Documents/in/DPPH">DPPH</a><script data-card-contents-for-ri="382472" type="text/json">{"id":382472,"name":"DPPH","url":"https://www.academia.edu/Documents/in/DPPH?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=43897420]'), work: {"id":43897420,"title":"EVALUATION OF SOME CHEMICAL CONSTITUENTS, ANTIOXIDANT, ANTIBACTERIAL AND ANTICANCER ACTIVITIES OF BETA VULGARIS L. ROOT","created_at":"2020-08-19T05:59:38.800-07:00","url":"https://www.academia.edu/43897420/EVALUATION_OF_SOME_CHEMICAL_CONSTITUENTS_ANTIOXIDANT_ANTIBACTERIAL_AND_ANTICANCER_ACTIVITIES_OF_BETA_VULGARIS_L_ROOT?f_ri=2018875","dom_id":"work_43897420","summary":"Beta vulgaris is belonging to the family Che-nopodiaceae and has several varieties with bulb colors ranging from yellow to red. Deep red-colored beet roots are the most popular for human consumption, both cooked and raw as salad or juice. The ethanolic extract of beetroots contains valuable and active compounds such as carotenoids, phenols, flavonoids, tannin, alkaloids, vitamins C, B3, B6 and B9. Therefore, beetroot extract has antioxidant and antimicrobial activity against gram positive and negative bacteria. Gram-positive bacteria Staphylococcus aureus and Bacillus cereus demonstrated higher susceptibility than Gram-negative Escherichia coli and Pseudomonas typhi-mureum. Beta vulgaris ethanolic extract exhibit significant anticancer activity against lung (A549) but slight effect against colorectal adenocarcinoma Caco-2 cell lines at the high concentrations of etha-nolic extract (800 µg/ml).","downloadable_attachments":[{"id":64220645,"asset_id":43897420,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33397819,"first_name":"Gehan","last_name":"Safwat","domain_name":"cambridge","page_name":"GehanSafwat","display_name":"Gehan Safwat","profile_url":"https://cambridge.academia.edu/GehanSafwat?f_ri=2018875","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":22052,"name":"Flavonoids","url":"https://www.academia.edu/Documents/in/Flavonoids?f_ri=2018875","nofollow":true},{"id":22053,"name":"Carotenoids","url":"https://www.academia.edu/Documents/in/Carotenoids?f_ri=2018875","nofollow":true},{"id":347988,"name":"Phenols","url":"https://www.academia.edu/Documents/in/Phenols?f_ri=2018875","nofollow":true},{"id":382472,"name":"DPPH","url":"https://www.academia.edu/Documents/in/DPPH?f_ri=2018875","nofollow":true},{"id":913998,"name":"Antibacterial","url":"https://www.academia.edu/Documents/in/Antibacterial?f_ri=2018875"},{"id":1166928,"name":"Beta Vulgaris","url":"https://www.academia.edu/Documents/in/Beta_Vulgaris?f_ri=2018875"},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_43898115 coauthored" data-work_id="43898115" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/43898115/GC_MS_Analysis_Antioxidant_Antimicrobial_and_Anticancer_Activities_of_Extracts_from_Ficus_sycomorus_Fruits_and_Leaves">GC-MS Analysis, Antioxidant, Antimicrobial and Anticancer Activities of Extracts from Ficus sycomorus Fruits and Leaves</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Higher plants have been utilized worldwide as characteristic drug a long time to cure human diseases. About 80% of individuals globally use plants as safe sources of medication to cure human diseases through completely different medicine... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_43898115" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Higher plants have been utilized worldwide as characteristic drug a long time to cure human diseases. About 80% of individuals globally use plants as safe sources of medication to cure human diseases through completely different medicine system. One of the available indigenous medicinal plants, Ficus sycomorus belongs to the Moraceae family. The plant contains totally different teams of biologically active compounds that square measure chargeable for the biological activity. Ethanolic and ethyl acetate extracts of leaves of Ficus sycomorus contain higher concentrations of total phenols, flavonoids, tannins, alkaloids and steroids than the fruit extracts. Ethanolic extract in both fruits and leaves gave higher concentrations of phytochemical compounds than the ethyl acetate extracts. Therefore, fruit and leaves extract have antioxidant and antimicrobial activity against gram positive, negative bacteria and fungus. Also, the percentage of Liver cell line (HepG2), Colorectal adenocarcinoma (Caco-2) and Breast cell line (MCF-7) viability was decreased with increasing the concentrations of the ethanolic extract of fruits and leaves of Ficus sycomorus. The high concentrations of ethanolic extract of fruits caused high reduction in the viability of cancer cells, especially in Colorectal adenocarcinoma (Caco-2) cell line. In addition, phytochemical compound screened by GC-MS method. In GC-MS analysis, 12 bioactive phytochemical compounds were identified in fruits and 29 bioactive compounds were detected in leaves extract. These totally different active phytochemicals are found to possess a good vary of activities, which can facilitate within the protection against incurable diseases.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/43898115" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="beec19b724cd2a7bdeee5171304d745f" rel="nofollow" data-download="{"attachment_id":64221385,"asset_id":43898115,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/64221385/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33397819" href="https://cambridge.academia.edu/GehanSafwat">Gehan Safwat</a><script data-card-contents-for-user="33397819" type="text/json">{"id":33397819,"first_name":"Gehan","last_name":"Safwat","domain_name":"cambridge","page_name":"GehanSafwat","display_name":"Gehan Safwat","profile_url":"https://cambridge.academia.edu/GehanSafwat?f_ri=2018875","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-43898115">+1</span><div class="hidden js-additional-users-43898115"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/AbdelazeemAbdelrahman">Abdelrahman Abdelazeem</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-43898115'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-43898115').html(); 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container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_43898115 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="43898115"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43898115; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43898115]").text(description); $(".js-view-count-work_43898115").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_43898115").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="43898115"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">6</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="22052" rel="nofollow" href="https://www.academia.edu/Documents/in/Flavonoids">Flavonoids</a>, <script data-card-contents-for-ri="22052" type="text/json">{"id":22052,"name":"Flavonoids","url":"https://www.academia.edu/Documents/in/Flavonoids?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="24856" rel="nofollow" href="https://www.academia.edu/Documents/in/STEROIDS">STEROIDS</a>, <script data-card-contents-for-ri="24856" type="text/json">{"id":24856,"name":"STEROIDS","url":"https://www.academia.edu/Documents/in/STEROIDS?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="347988" rel="nofollow" href="https://www.academia.edu/Documents/in/Phenols">Phenols</a>, <script data-card-contents-for-ri="347988" type="text/json">{"id":347988,"name":"Phenols","url":"https://www.academia.edu/Documents/in/Phenols?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="382472" rel="nofollow" href="https://www.academia.edu/Documents/in/DPPH">DPPH</a><script data-card-contents-for-ri="382472" type="text/json">{"id":382472,"name":"DPPH","url":"https://www.academia.edu/Documents/in/DPPH?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=43898115]'), work: {"id":43898115,"title":"GC-MS Analysis, Antioxidant, Antimicrobial and Anticancer Activities of Extracts from Ficus sycomorus Fruits and Leaves","created_at":"2020-08-19T07:33:56.387-07:00","url":"https://www.academia.edu/43898115/GC_MS_Analysis_Antioxidant_Antimicrobial_and_Anticancer_Activities_of_Extracts_from_Ficus_sycomorus_Fruits_and_Leaves?f_ri=2018875","dom_id":"work_43898115","summary":"Higher plants have been utilized worldwide as characteristic drug a long time to cure human diseases. About 80% of individuals globally use plants as safe sources of medication to cure human diseases through completely different medicine system. One of the available indigenous medicinal plants, Ficus sycomorus belongs to the Moraceae family. The plant contains totally different teams of biologically active compounds that square measure chargeable for the biological activity. Ethanolic and ethyl acetate extracts of leaves of Ficus sycomorus contain higher concentrations of total phenols, flavonoids, tannins, alkaloids and steroids than the fruit extracts. Ethanolic extract in both fruits and leaves gave higher concentrations of phytochemical compounds than the ethyl acetate extracts. Therefore, fruit and leaves extract have antioxidant and antimicrobial activity against gram positive, negative bacteria and fungus. Also, the percentage of Liver cell line (HepG2), Colorectal adenocarcinoma (Caco-2) and Breast cell line (MCF-7) viability was decreased with increasing the concentrations of the ethanolic extract of fruits and leaves of Ficus sycomorus. The high concentrations of ethanolic extract of fruits caused high reduction in the viability of cancer cells, especially in Colorectal adenocarcinoma (Caco-2) cell line. In addition, phytochemical compound screened by GC-MS method. In GC-MS analysis, 12 bioactive phytochemical compounds were identified in fruits and 29 bioactive compounds were detected in leaves extract. These totally different active phytochemicals are found to possess a good vary of activities, which can facilitate within the protection against incurable diseases.","downloadable_attachments":[{"id":64221385,"asset_id":43898115,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33397819,"first_name":"Gehan","last_name":"Safwat","domain_name":"cambridge","page_name":"GehanSafwat","display_name":"Gehan Safwat","profile_url":"https://cambridge.academia.edu/GehanSafwat?f_ri=2018875","photo":"/images/s65_no_pic.png"},{"id":168102610,"first_name":"Abdelrahman","last_name":"Abdelazeem","domain_name":"independent","page_name":"AbdelazeemAbdelrahman","display_name":"Abdelrahman Abdelazeem","profile_url":"https://independent.academia.edu/AbdelazeemAbdelrahman?f_ri=2018875","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":22052,"name":"Flavonoids","url":"https://www.academia.edu/Documents/in/Flavonoids?f_ri=2018875","nofollow":true},{"id":24856,"name":"STEROIDS","url":"https://www.academia.edu/Documents/in/STEROIDS?f_ri=2018875","nofollow":true},{"id":347988,"name":"Phenols","url":"https://www.academia.edu/Documents/in/Phenols?f_ri=2018875","nofollow":true},{"id":382472,"name":"DPPH","url":"https://www.academia.edu/Documents/in/DPPH?f_ri=2018875","nofollow":true},{"id":913998,"name":"Antibacterial","url":"https://www.academia.edu/Documents/in/Antibacterial?f_ri=2018875"},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_44691910" data-work_id="44691910" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/44691910/Phyco_fabrication_of_bimetallic_nanoparticles_zinc_selenium_using_aqueous_extract_of_Gracilaria_corticata_and_its_biological_activity_potentials">Phyco-fabrication of bimetallic nanoparticles (zinc-selenium) using aqueous extract of Gracilaria corticata and its biological activity potentials</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Zinc selenium nanoparticles (ZnSe NPs) are widely used in many industrial, environmental and biomedical fields. However, the biological potential of ZnSe NPs has not been studied in detail. The present study focused on ZnSe NPs... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_44691910" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Zinc selenium nanoparticles (ZnSe NPs) are widely used in many industrial, environmental and biomedical fields. However, the biological potential of ZnSe NPs has not been studied in detail. The present study focused on ZnSe NPs algae-based synthesis using aqueous extract of seaweed, Gracilaria corticata. Successfully synthesized ZnSe NPs were characterized by analytical methods such as UV-Vis, FTIR, XRD, SEM, TEM, DLS, Zeta potential and EDX analyses; additionally, the biological function of ZnSe NPs was performed. The ZnSe NPs exhibited a certain absorbance peak at 350-400 nm in the UV-vis spectrum. The FTIR showed the possible functional groups associated with biomolecules involved the ZnSe NPs synthesis. SEM and TEM demonstrated that ZnSe NPs were spherical in shape with size range of 50-250. XRD and EDX showed NPs crystallite size of 55.5 nm and their elemental composition that constitute selenium and zinc (1:1.5 ratio). These NPs showed antioxidant activity about 67% and antibacterial activity against broad spectrum of bacterial strains. Biofilm inhibition by ZnSe NPs was occurred on P. aeruginosa and B. subtilis at 50 and 40 μg/ml. Anticancer activity against HTB-9 (ATCC 5637) and KB (ATCC CCL-17) with IC 50 of 19.24 and 28.42 μg/ml. In conclusion, the green synthesis of ZnSe NPs can provide the requisite criteria for therapeutic and preventive applications.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/44691910" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="322f7016f7a2e9383281b3d08431a712" rel="nofollow" data-download="{"attachment_id":89610729,"asset_id":44691910,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/89610729/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="421433" href="https://nurserystudent.academia.edu/Abdolrazaghmarzban">Abdolrazagh marzban</a><script data-card-contents-for-user="421433" type="text/json">{"id":421433,"first_name":"Abdolrazagh","last_name":"marzban","domain_name":"nurserystudent","page_name":"Abdolrazaghmarzban","display_name":"Abdolrazagh marzban","profile_url":"https://nurserystudent.academia.edu/Abdolrazaghmarzban?f_ri=2018875","photo":"https://0.academia-photos.com/421433/12285158/13708949/s65_abdolrazagh.marzban.jpg"}</script></span></span></li><li class="js-paper-rank-work_44691910 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="44691910"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 44691910, container: ".js-paper-rank-work_44691910", }); });</script></li><li class="js-percentile-work_44691910 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 44691910; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_44691910"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_44691910 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="44691910"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 44691910; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=44691910]").text(description); $(".js-view-count-work_44691910").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_44691910").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="44691910"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">6</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="290432" rel="nofollow" href="https://www.academia.edu/Documents/in/Antibacterial_activity">Antibacterial activity</a>, <script data-card-contents-for-ri="290432" type="text/json">{"id":290432,"name":"Antibacterial activity","url":"https://www.academia.edu/Documents/in/Antibacterial_activity?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="290433" rel="nofollow" href="https://www.academia.edu/Documents/in/Antioxidant_Activity">Antioxidant Activity</a>, <script data-card-contents-for-ri="290433" type="text/json">{"id":290433,"name":"Antioxidant Activity","url":"https://www.academia.edu/Documents/in/Antioxidant_Activity?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="783432" rel="nofollow" href="https://www.academia.edu/Documents/in/Biological_activity">Biological activity</a>, <script data-card-contents-for-ri="783432" type="text/json">{"id":783432,"name":"Biological activity","url":"https://www.academia.edu/Documents/in/Biological_activity?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2018875" rel="nofollow" href="https://www.academia.edu/Documents/in/Anticancer_activity">Anticancer activity</a><script data-card-contents-for-ri="2018875" type="text/json">{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=44691910]'), work: {"id":44691910,"title":"Phyco-fabrication of bimetallic nanoparticles (zinc-selenium) using aqueous extract of Gracilaria corticata and its biological activity potentials","created_at":"2020-12-12T18:01:24.011-08:00","url":"https://www.academia.edu/44691910/Phyco_fabrication_of_bimetallic_nanoparticles_zinc_selenium_using_aqueous_extract_of_Gracilaria_corticata_and_its_biological_activity_potentials?f_ri=2018875","dom_id":"work_44691910","summary":"Zinc selenium nanoparticles (ZnSe NPs) are widely used in many industrial, environmental and biomedical fields. However, the biological potential of ZnSe NPs has not been studied in detail. The present study focused on ZnSe NPs algae-based synthesis using aqueous extract of seaweed, Gracilaria corticata. Successfully synthesized ZnSe NPs were characterized by analytical methods such as UV-Vis, FTIR, XRD, SEM, TEM, DLS, Zeta potential and EDX analyses; additionally, the biological function of ZnSe NPs was performed. The ZnSe NPs exhibited a certain absorbance peak at 350-400 nm in the UV-vis spectrum. The FTIR showed the possible functional groups associated with biomolecules involved the ZnSe NPs synthesis. SEM and TEM demonstrated that ZnSe NPs were spherical in shape with size range of 50-250. XRD and EDX showed NPs crystallite size of 55.5 nm and their elemental composition that constitute selenium and zinc (1:1.5 ratio). These NPs showed antioxidant activity about 67% and antibacterial activity against broad spectrum of bacterial strains. Biofilm inhibition by ZnSe NPs was occurred on P. aeruginosa and B. subtilis at 50 and 40 μg/ml. Anticancer activity against HTB-9 (ATCC 5637) and KB (ATCC CCL-17) with IC 50 of 19.24 and 28.42 μg/ml. In conclusion, the green synthesis of ZnSe NPs can provide the requisite criteria for therapeutic and preventive applications.","downloadable_attachments":[{"id":89610729,"asset_id":44691910,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":421433,"first_name":"Abdolrazagh","last_name":"marzban","domain_name":"nurserystudent","page_name":"Abdolrazaghmarzban","display_name":"Abdolrazagh marzban","profile_url":"https://nurserystudent.academia.edu/Abdolrazaghmarzban?f_ri=2018875","photo":"https://0.academia-photos.com/421433/12285158/13708949/s65_abdolrazagh.marzban.jpg"}],"research_interests":[{"id":290432,"name":"Antibacterial activity","url":"https://www.academia.edu/Documents/in/Antibacterial_activity?f_ri=2018875","nofollow":true},{"id":290433,"name":"Antioxidant Activity","url":"https://www.academia.edu/Documents/in/Antioxidant_Activity?f_ri=2018875","nofollow":true},{"id":783432,"name":"Biological activity","url":"https://www.academia.edu/Documents/in/Biological_activity?f_ri=2018875","nofollow":true},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true},{"id":2543609,"name":"zinc selenide","url":"https://www.academia.edu/Documents/in/zinc_selenide?f_ri=2018875"},{"id":2607684,"name":"Keywords - Gracilaria corticata","url":"https://www.academia.edu/Documents/in/Keywords_-_Gracilaria_corticata?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_72394982" data-work_id="72394982" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/72394982/H_NMR_Characteristics_of_Bis_naphthalimide_Derivatives">H-NMR Characteristics of Bis-naphthalimide Derivatives</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Chemotherapy is still the most important method of cancer treatment. To make this method more effective and safe, new drugs to destroy cancer cells are needed. Some bis-naphthalimide derivatives show potential anticancer activity via an... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_72394982" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Chemotherapy is still the most important method of cancer treatment. To make this method more effective and safe, new drugs to destroy cancer cells are needed. Some bis-naphthalimide derivatives show potential anticancer activity via an intercalation mechanism. A higher degree of DNA intercalation corresponds to better therapeutic effects. The degree of intercalation of naphthalimides depends on their structure, molecular dynamics and intermolecular interactions with DNA. In order to apply any active substance as a drug, its molecular dynamics as well as possible interactions with target molecules have to be examined in exhaustive details. This paper describes a practical preparation of some novel bis-naphthalimide derivatives with different functional groups and their FTIR and 1 Hand 13 C-NMR spectral characteristics. To determine the molecular dynamics of the obtained compounds the temperature, their 1 H-NMR spectra were measured. It has been clearly proven in this paper that the unusual temperature-dependent 1 H-NMR behavior of the aromatic protons of phthalimide derivatives, previously described in the literature as "hypersensitivity" and explained by n-π interactions and molecular motions of aromatic amide rings, is a result of temperature driven changes of the geometry of carbonyl groups.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/72394982" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="870eb0f71a8a4a3cf089367d441f9da5" rel="nofollow" data-download="{"attachment_id":81337063,"asset_id":72394982,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/81337063/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="37371132" href="https://independent.academia.edu/Bogumi%C5%82Brycki">Bogumił Brycki</a><script data-card-contents-for-user="37371132" type="text/json">{"id":37371132,"first_name":"Bogumił","last_name":"Brycki","domain_name":"independent","page_name":"BogumiłBrycki","display_name":"Bogumił Brycki","profile_url":"https://independent.academia.edu/Bogumi%C5%82Brycki?f_ri=2018875","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_72394982 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="72394982"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 72394982, container: ".js-paper-rank-work_72394982", }); });</script></li><li class="js-percentile-work_72394982 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72394982; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_72394982"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_72394982 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="72394982"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72394982; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72394982]").text(description); $(".js-view-count-work_72394982").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_72394982").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="72394982"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="48057" rel="nofollow" href="https://www.academia.edu/Documents/in/DNA">DNA</a>, <script data-card-contents-for-ri="48057" type="text/json">{"id":48057,"name":"DNA","url":"https://www.academia.edu/Documents/in/DNA?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="991927" rel="nofollow" href="https://www.academia.edu/Documents/in/FTIR_Spectra">FTIR Spectra</a>, <script data-card-contents-for-ri="991927" type="text/json">{"id":991927,"name":"FTIR Spectra","url":"https://www.academia.edu/Documents/in/FTIR_Spectra?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2018875" rel="nofollow" href="https://www.academia.edu/Documents/in/Anticancer_activity">Anticancer activity</a><script data-card-contents-for-ri="2018875" type="text/json">{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=72394982]'), work: {"id":72394982,"title":"H-NMR Characteristics of Bis-naphthalimide Derivatives","created_at":"2022-02-24T02:52:08.313-08:00","url":"https://www.academia.edu/72394982/H_NMR_Characteristics_of_Bis_naphthalimide_Derivatives?f_ri=2018875","dom_id":"work_72394982","summary":"Chemotherapy is still the most important method of cancer treatment. To make this method more effective and safe, new drugs to destroy cancer cells are needed. Some bis-naphthalimide derivatives show potential anticancer activity via an intercalation mechanism. A higher degree of DNA intercalation corresponds to better therapeutic effects. The degree of intercalation of naphthalimides depends on their structure, molecular dynamics and intermolecular interactions with DNA. In order to apply any active substance as a drug, its molecular dynamics as well as possible interactions with target molecules have to be examined in exhaustive details. This paper describes a practical preparation of some novel bis-naphthalimide derivatives with different functional groups and their FTIR and 1 Hand 13 C-NMR spectral characteristics. To determine the molecular dynamics of the obtained compounds the temperature, their 1 H-NMR spectra were measured. It has been clearly proven in this paper that the unusual temperature-dependent 1 H-NMR behavior of the aromatic protons of phthalimide derivatives, previously described in the literature as \"hypersensitivity\" and explained by n-π interactions and molecular motions of aromatic amide rings, is a result of temperature driven changes of the geometry of carbonyl groups.","downloadable_attachments":[{"id":81337063,"asset_id":72394982,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":37371132,"first_name":"Bogumił","last_name":"Brycki","domain_name":"independent","page_name":"BogumiłBrycki","display_name":"Bogumił Brycki","profile_url":"https://independent.academia.edu/Bogumi%C5%82Brycki?f_ri=2018875","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":48057,"name":"DNA","url":"https://www.academia.edu/Documents/in/DNA?f_ri=2018875","nofollow":true},{"id":991927,"name":"FTIR Spectra","url":"https://www.academia.edu/Documents/in/FTIR_Spectra?f_ri=2018875","nofollow":true},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_81798246" data-work_id="81798246" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/81798246/New_Adamantane_Phenylalkylamines_with_%CF%83_Receptor_Binding_Affinity_and_Anticancer_Activity_Associated_with_Putative_Antagonism_of_Neuropathic_Pain">New Adamantane Phenylalkylamines with σ-Receptor Binding Affinity and Anticancer Activity, Associated with Putative Antagonism of Neuropathic Pain</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The synthesis of the adamantane phenylalkylamines 2a−d, 3a−c, and 4a−e is described. These compounds exhibited significant antiproliferative activity, in vitro, against eight cancer cell lines tested. The σ 1 , σ 2 , and sodium channel... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_81798246" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The synthesis of the adamantane phenylalkylamines 2a−d, 3a−c, and 4a−e is described. These compounds exhibited significant antiproliferative activity, in vitro, against eight cancer cell lines tested. The σ 1 , σ 2 , and sodium channel binding affinities of compounds 2a, 3a, 4a, and 4c−e were investigated. The most interesting analogue, 4a, exhibited significant in vivo anticancer profile on pancreas, prostate, leukemia, and ovarian cancer cell line xenografts together with apoptosis and caspase-3 activation. Inhibition of the cancer cells cycle at the sub-G1 level was also obtained with 4a. Finally, encouraging results were observed with 4a in vivo on mice, suggesting putative antimetastatic and analgesic activities of this compound.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/81798246" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3e21e42db5b82584037c87065b79ef58" rel="nofollow" data-download="{"attachment_id":87717810,"asset_id":81798246,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/87717810/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="200613215" href="https://independent.academia.edu/HumairaKhan94">Humaira Khan</a><script data-card-contents-for-user="200613215" type="text/json">{"id":200613215,"first_name":"Humaira","last_name":"Khan","domain_name":"independent","page_name":"HumairaKhan94","display_name":"Humaira Khan","profile_url":"https://independent.academia.edu/HumairaKhan94?f_ri=2018875","photo":"https://0.academia-photos.com/200613215/62094170/50380686/s65_humaira.khan.jpeg"}</script></span></span></li><li class="js-paper-rank-work_81798246 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="81798246"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 81798246, container: ".js-paper-rank-work_81798246", }); });</script></li><li class="js-percentile-work_81798246 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 81798246; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_81798246"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_81798246 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="81798246"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 81798246; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=81798246]").text(description); $(".js-view-count-work_81798246").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_81798246").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="81798246"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="145" rel="nofollow" href="https://www.academia.edu/Documents/in/Biochemistry">Biochemistry</a>, <script data-card-contents-for-ri="145" type="text/json">{"id":145,"name":"Biochemistry","url":"https://www.academia.edu/Documents/in/Biochemistry?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="523" rel="nofollow" href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a>, <script data-card-contents-for-ri="523" type="text/json">{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="619" rel="nofollow" href="https://www.academia.edu/Documents/in/Hematology">Hematology</a>, <script data-card-contents-for-ri="619" type="text/json">{"id":619,"name":"Hematology","url":"https://www.academia.edu/Documents/in/Hematology?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2375" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicinal_Chemistry">Medicinal Chemistry</a><script data-card-contents-for-ri="2375" type="text/json">{"id":2375,"name":"Medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Medicinal_Chemistry?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=81798246]'), work: {"id":81798246,"title":"New Adamantane Phenylalkylamines with σ-Receptor Binding Affinity and Anticancer Activity, Associated with Putative Antagonism of Neuropathic Pain","created_at":"2022-06-18T22:51:15.280-07:00","url":"https://www.academia.edu/81798246/New_Adamantane_Phenylalkylamines_with_%CF%83_Receptor_Binding_Affinity_and_Anticancer_Activity_Associated_with_Putative_Antagonism_of_Neuropathic_Pain?f_ri=2018875","dom_id":"work_81798246","summary":"The synthesis of the adamantane phenylalkylamines 2a−d, 3a−c, and 4a−e is described. These compounds exhibited significant antiproliferative activity, in vitro, against eight cancer cell lines tested. The σ 1 , σ 2 , and sodium channel binding affinities of compounds 2a, 3a, 4a, and 4c−e were investigated. The most interesting analogue, 4a, exhibited significant in vivo anticancer profile on pancreas, prostate, leukemia, and ovarian cancer cell line xenografts together with apoptosis and caspase-3 activation. Inhibition of the cancer cells cycle at the sub-G1 level was also obtained with 4a. Finally, encouraging results were observed with 4a in vivo on mice, suggesting putative antimetastatic and analgesic activities of this compound.","downloadable_attachments":[{"id":87717810,"asset_id":81798246,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":200613215,"first_name":"Humaira","last_name":"Khan","domain_name":"independent","page_name":"HumairaKhan94","display_name":"Humaira Khan","profile_url":"https://independent.academia.edu/HumairaKhan94?f_ri=2018875","photo":"https://0.academia-photos.com/200613215/62094170/50380686/s65_humaira.khan.jpeg"}],"research_interests":[{"id":145,"name":"Biochemistry","url":"https://www.academia.edu/Documents/in/Biochemistry?f_ri=2018875","nofollow":true},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry?f_ri=2018875","nofollow":true},{"id":619,"name":"Hematology","url":"https://www.academia.edu/Documents/in/Hematology?f_ri=2018875","nofollow":true},{"id":2375,"name":"Medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Medicinal_Chemistry?f_ri=2018875","nofollow":true},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=2018875"},{"id":9113,"name":"Cell Cycle","url":"https://www.academia.edu/Documents/in/Cell_Cycle?f_ri=2018875"},{"id":13827,"name":"Cell Biology","url":"https://www.academia.edu/Documents/in/Cell_Biology?f_ri=2018875"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=2018875"},{"id":247477,"name":"Caspase","url":"https://www.academia.edu/Documents/in/Caspase?f_ri=2018875"},{"id":251671,"name":"Compounds","url":"https://www.academia.edu/Documents/in/Compounds?f_ri=2018875"},{"id":319664,"name":"Cancer Cell Lines","url":"https://www.academia.edu/Documents/in/Cancer_Cell_Lines?f_ri=2018875"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation?f_ri=2018875"},{"id":1114941,"name":"Antiproliferative Activity","url":"https://www.academia.edu/Documents/in/Antiproliferative_Activity?f_ri=2018875"},{"id":1190805,"name":"Adamantane","url":"https://www.academia.edu/Documents/in/Adamantane?f_ri=2018875"},{"id":1212103,"name":"Antineoplastic Agents","url":"https://www.academia.edu/Documents/in/Antineoplastic_Agents?f_ri=2018875"},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_40766707" data-work_id="40766707" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/40766707/Novel_Pyrazolyl_Benzoxazole_Conjugates_Design_Synthesis_Molecular_Docking_Studies_and_in_vitro_Anticancer_Activities">Novel Pyrazolyl Benzoxazole Conjugates: Design, Synthesis, Molecular Docking Studies and in vitro Anticancer Activities</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Nowadays, hybrid drugs have gained a significant role in the treatment of different health problems. Most of the hybrid molecules with different heterocyclic moieties were proved to be potent anti-tumor agents in cancer... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_40766707" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Nowadays, hybrid drugs have gained a significant role in the treatment of different health problems. Most of the hybrid molecules with different heterocyclic moieties were proved to be potent anti-tumor agents in cancer chemotherapy. Hence, the present study is aimed at the evaluation of in vitro anticancer activity of novel hybrid molecules (pyrazolyl benzoxazole conjugates) and to investigate their anticancer activity by molecular docking studies. Methods: Designed, synthesized and characterized the novel pyrazolyl benzoxazole conjugates. Anticancer activity of these compounds was determined by SRB assay. Then molecular docking studies were carried out against proto-oncogene tyrosine-protein kinase (ATP-Src, PDB: 2BDF), a putative target for cancer. Results: All the synthesized compound derivatives were evaluated against MCF-7, KB, Hop62 and A549 cancer cell lines. Compounds 9b and 9c exhibited excellent anticancer activities with GI 50 values of <0.1 µM against MCF-7 and A549 cell lines. Compound 9e exhibited good antitumor activity on MCF-7 and A-549 with GI 50 values of 0.12 µM and 0.19 µM respectively. Compound 9g showed better anticancer activity on A-549 cancer cell line with GI 50 value of 0.34 µM. Conclusion: The two-hybrid molecules 9b and 9c are found to be comparably potent with the standard drug doxorubicin and may act as drug lead compounds in medicinal chemistry aspect. The present docking investigation proved that having benzoxazole of compound 9c at benzofuran of reference compound N-acetyl pyrazoline derivative might be valid for contributing to anti-cancer activity.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/40766707" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fc5fc6769fe244c1cd915f14f8d58b24" rel="nofollow" data-download="{"attachment_id":61046787,"asset_id":40766707,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/61046787/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="5803185" href="https://independent.academia.edu/RatnakaramVenkataNadh">Ratnakaram Venkata Nadh</a><script data-card-contents-for-user="5803185" type="text/json">{"id":5803185,"first_name":"Ratnakaram","last_name":"Venkata Nadh","domain_name":"independent","page_name":"RatnakaramVenkataNadh","display_name":"Ratnakaram Venkata Nadh","profile_url":"https://independent.academia.edu/RatnakaramVenkataNadh?f_ri=2018875","photo":"https://0.academia-photos.com/5803185/29204422/27207733/s65_ratnakaram.venkata_nadh.jpg"}</script></span></span></li><li class="js-paper-rank-work_40766707 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="40766707"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 40766707, container: ".js-paper-rank-work_40766707", }); 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$(".js-view-count[data-work-id=40766707]").text(description); $(".js-view-count-work_40766707").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_40766707").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="40766707"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="314240" rel="nofollow" href="https://www.academia.edu/Documents/in/Doxorubicin">Doxorubicin</a>, <script data-card-contents-for-ri="314240" type="text/json">{"id":314240,"name":"Doxorubicin","url":"https://www.academia.edu/Documents/in/Doxorubicin?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="801412" rel="nofollow" href="https://www.academia.edu/Documents/in/Pyrazoles">Pyrazoles</a>, <script data-card-contents-for-ri="801412" type="text/json">{"id":801412,"name":"Pyrazoles","url":"https://www.academia.edu/Documents/in/Pyrazoles?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="824508" rel="nofollow" href="https://www.academia.edu/Documents/in/Benzoxazoles">Benzoxazoles</a>, <script data-card-contents-for-ri="824508" type="text/json">{"id":824508,"name":"Benzoxazoles","url":"https://www.academia.edu/Documents/in/Benzoxazoles?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2018875" rel="nofollow" href="https://www.academia.edu/Documents/in/Anticancer_activity">Anticancer activity</a><script data-card-contents-for-ri="2018875" type="text/json">{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=40766707]'), work: {"id":40766707,"title":"Novel Pyrazolyl Benzoxazole Conjugates: Design, Synthesis, Molecular Docking Studies and in vitro Anticancer Activities","created_at":"2019-10-28T08:54:16.405-07:00","url":"https://www.academia.edu/40766707/Novel_Pyrazolyl_Benzoxazole_Conjugates_Design_Synthesis_Molecular_Docking_Studies_and_in_vitro_Anticancer_Activities?f_ri=2018875","dom_id":"work_40766707","summary":"Background: Nowadays, hybrid drugs have gained a significant role in the treatment of different health problems. Most of the hybrid molecules with different heterocyclic moieties were proved to be potent anti-tumor agents in cancer chemotherapy. Hence, the present study is aimed at the evaluation of in vitro anticancer activity of novel hybrid molecules (pyrazolyl benzoxazole conjugates) and to investigate their anticancer activity by molecular docking studies. Methods: Designed, synthesized and characterized the novel pyrazolyl benzoxazole conjugates. Anticancer activity of these compounds was determined by SRB assay. Then molecular docking studies were carried out against proto-oncogene tyrosine-protein kinase (ATP-Src, PDB: 2BDF), a putative target for cancer. Results: All the synthesized compound derivatives were evaluated against MCF-7, KB, Hop62 and A549 cancer cell lines. Compounds 9b and 9c exhibited excellent anticancer activities with GI 50 values of \u003c0.1 µM against MCF-7 and A549 cell lines. Compound 9e exhibited good antitumor activity on MCF-7 and A-549 with GI 50 values of 0.12 µM and 0.19 µM respectively. Compound 9g showed better anticancer activity on A-549 cancer cell line with GI 50 value of 0.34 µM. Conclusion: The two-hybrid molecules 9b and 9c are found to be comparably potent with the standard drug doxorubicin and may act as drug lead compounds in medicinal chemistry aspect. The present docking investigation proved that having benzoxazole of compound 9c at benzofuran of reference compound N-acetyl pyrazoline derivative might be valid for contributing to anti-cancer activity.","downloadable_attachments":[{"id":61046787,"asset_id":40766707,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":5803185,"first_name":"Ratnakaram","last_name":"Venkata Nadh","domain_name":"independent","page_name":"RatnakaramVenkataNadh","display_name":"Ratnakaram Venkata Nadh","profile_url":"https://independent.academia.edu/RatnakaramVenkataNadh?f_ri=2018875","photo":"https://0.academia-photos.com/5803185/29204422/27207733/s65_ratnakaram.venkata_nadh.jpg"}],"research_interests":[{"id":314240,"name":"Doxorubicin","url":"https://www.academia.edu/Documents/in/Doxorubicin?f_ri=2018875","nofollow":true},{"id":801412,"name":"Pyrazoles","url":"https://www.academia.edu/Documents/in/Pyrazoles?f_ri=2018875","nofollow":true},{"id":824508,"name":"Benzoxazoles","url":"https://www.academia.edu/Documents/in/Benzoxazoles?f_ri=2018875","nofollow":true},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true},{"id":3157438,"name":"Molecular docking studies","url":"https://www.academia.edu/Documents/in/Molecular_docking_studies?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_79284293" data-work_id="79284293" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/79284293/Green_Synthesis_of_Nanomaterials_and_Their_Utilization_as_Potential_Vehicles_for_Targeted_Cancer_Drug_Delivery">Green Synthesis of Nanomaterials and Their Utilization as Potential Vehicles for Targeted Cancer Drug Delivery</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A nanoparticle (NP) is a microscopic particle with a length of two or three dimensions greater than 0.001 micrometer (1 nanometer =10 −9 metre). NPs may be classified into different classes based on their specific properties, shapes or... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_79284293" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A nanoparticle (NP) is a microscopic particle with a length of two or three dimensions greater than 0.001 micrometer (1 nanometer =10 −9 metre). NPs may be classified into different classes based on their specific properties, shapes or sizes, and high surface area-to-volume ratio. Nanoparticles have a remarkable capacity as 'magic bullets' stacked with herbicides, fungicides, supplements, fertilizers or nucleic acids, specializing in expressing plant tissues to deliver their charge to the appropriate piece of the plant to perform desired outcomes. The smart design and synthesis of a library of nanomaterials, exact control over their physicochemical properties and simplicity of their surface functionalization to assemble explicitness is to be certain fundamental for the achievement of disease treatment and harmfulness in the biological systems. Green techniques for nanomaterial synthesis observe natural organic systems to nanomaterial production. Green synthesized nanomaterials are at present powerful and significant tools for protecting the drug from the dangerous surroundings in addition to overcoming the organic obstacles to access of the drug in targeted tissues and dealing with drug resistance. NPs were extensively utilized in numerous biomedical applications, site-specific drug delivery systems and cellular uptake because of their inert nature, stability, high dispersity, non-cytotoxicity, and biocompatibility. Nanoparticles may be programmed for recognizing the cancerous cells and giving selective and correct drug delivery avoiding interaction with the healthy cells. However, usage of those NPs is restrained through factors like lack of stability in adversarial environment, concerns regarding bioaccumulation and toxicity, need of relatively trained employees for device assembly and operation, and problems with reproducibility and affordability.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/79284293" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c90a973fbce040972816cb01013b2d14" rel="nofollow" data-download="{"attachment_id":86051363,"asset_id":79284293,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/86051363/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="13473331" href="https://independent.academia.edu/KevinNelson2">Horizon Research Publishing(HRPUB) Kevin Nelson</a><script data-card-contents-for-user="13473331" type="text/json">{"id":13473331,"first_name":"Horizon Research Publishing(HRPUB)","last_name":"Kevin Nelson","domain_name":"independent","page_name":"KevinNelson2","display_name":"Horizon Research Publishing(HRPUB) Kevin Nelson","profile_url":"https://independent.academia.edu/KevinNelson2?f_ri=2018875","photo":"https://0.academia-photos.com/13473331/45851996/39214071/s65_horizon_research_publishing_hrpub_.kevin_nelson.jpg"}</script></span></span></li><li class="js-paper-rank-work_79284293 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="79284293"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 79284293, container: ".js-paper-rank-work_79284293", }); 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$(".js-view-count[data-work-id=79284293]").text(description); $(".js-view-count-work_79284293").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_79284293").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="79284293"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="140" rel="nofollow" href="https://www.academia.edu/Documents/in/Pharmacology">Pharmacology</a>, <script data-card-contents-for-ri="140" type="text/json">{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="656" rel="nofollow" href="https://www.academia.edu/Documents/in/Pharmacy">Pharmacy</a>, <script data-card-contents-for-ri="656" type="text/json">{"id":656,"name":"Pharmacy","url":"https://www.academia.edu/Documents/in/Pharmacy?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="11257" rel="nofollow" href="https://www.academia.edu/Documents/in/Drug_delivery">Drug delivery</a>, <script data-card-contents-for-ri="11257" type="text/json">{"id":11257,"name":"Drug delivery","url":"https://www.academia.edu/Documents/in/Drug_delivery?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="11972" rel="nofollow" href="https://www.academia.edu/Documents/in/Nanomedicine">Nanomedicine</a><script data-card-contents-for-ri="11972" type="text/json">{"id":11972,"name":"Nanomedicine","url":"https://www.academia.edu/Documents/in/Nanomedicine?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=79284293]'), work: {"id":79284293,"title":"Green Synthesis of Nanomaterials and Their Utilization as Potential Vehicles for Targeted Cancer Drug Delivery","created_at":"2022-05-17T00:24:19.154-07:00","url":"https://www.academia.edu/79284293/Green_Synthesis_of_Nanomaterials_and_Their_Utilization_as_Potential_Vehicles_for_Targeted_Cancer_Drug_Delivery?f_ri=2018875","dom_id":"work_79284293","summary":"A nanoparticle (NP) is a microscopic particle with a length of two or three dimensions greater than 0.001 micrometer (1 nanometer =10 −9 metre). NPs may be classified into different classes based on their specific properties, shapes or sizes, and high surface area-to-volume ratio. Nanoparticles have a remarkable capacity as 'magic bullets' stacked with herbicides, fungicides, supplements, fertilizers or nucleic acids, specializing in expressing plant tissues to deliver their charge to the appropriate piece of the plant to perform desired outcomes. The smart design and synthesis of a library of nanomaterials, exact control over their physicochemical properties and simplicity of their surface functionalization to assemble explicitness is to be certain fundamental for the achievement of disease treatment and harmfulness in the biological systems. Green techniques for nanomaterial synthesis observe natural organic systems to nanomaterial production. Green synthesized nanomaterials are at present powerful and significant tools for protecting the drug from the dangerous surroundings in addition to overcoming the organic obstacles to access of the drug in targeted tissues and dealing with drug resistance. NPs were extensively utilized in numerous biomedical applications, site-specific drug delivery systems and cellular uptake because of their inert nature, stability, high dispersity, non-cytotoxicity, and biocompatibility. Nanoparticles may be programmed for recognizing the cancerous cells and giving selective and correct drug delivery avoiding interaction with the healthy cells. However, usage of those NPs is restrained through factors like lack of stability in adversarial environment, concerns regarding bioaccumulation and toxicity, need of relatively trained employees for device assembly and operation, and problems with reproducibility and affordability.","downloadable_attachments":[{"id":86051363,"asset_id":79284293,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":13473331,"first_name":"Horizon Research Publishing(HRPUB)","last_name":"Kevin Nelson","domain_name":"independent","page_name":"KevinNelson2","display_name":"Horizon Research Publishing(HRPUB) Kevin Nelson","profile_url":"https://independent.academia.edu/KevinNelson2?f_ri=2018875","photo":"https://0.academia-photos.com/13473331/45851996/39214071/s65_horizon_research_publishing_hrpub_.kevin_nelson.jpg"}],"research_interests":[{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology?f_ri=2018875","nofollow":true},{"id":656,"name":"Pharmacy","url":"https://www.academia.edu/Documents/in/Pharmacy?f_ri=2018875","nofollow":true},{"id":11257,"name":"Drug delivery","url":"https://www.academia.edu/Documents/in/Drug_delivery?f_ri=2018875","nofollow":true},{"id":11972,"name":"Nanomedicine","url":"https://www.academia.edu/Documents/in/Nanomedicine?f_ri=2018875","nofollow":true},{"id":13621,"name":"Nanoparticles","url":"https://www.academia.edu/Documents/in/Nanoparticles?f_ri=2018875"},{"id":487928,"name":"Green Synthesis","url":"https://www.academia.edu/Documents/in/Green_Synthesis?f_ri=2018875"},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_48411859" data-work_id="48411859" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/48411859/Inhibition_of_Horseradish_Peroxidase_HRP_by_a_Nonhydrophobic_Component_of_Urine_A_Caution_for_Immunoassays">Inhibition of Horseradish Peroxidase (HRP) by a Nonhydrophobic Component of Urine: A Caution for Immunoassays</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Undiluted urine mixed directly with HRP suppresses generation of enzyme product to less than 80% of that seen in buffer controls. Incubating dilutions of various urine preparations with HRP immobilized on concanavalin A coated microtiter... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_48411859" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Undiluted urine mixed directly with HRP suppresses generation of enzyme product to less than 80% of that seen in buffer controls. Incubating dilutions of various urine preparations with HRP immobilized on concanavalin A coated microtiter plates reveals that the source of urine or HRP, and the type of HRP substrate used have minimal effect on the degree of HRP suppression; only dilutions of urine greater than 8-fold with buffer produce HRP activities equivalent to those in buffer. Treating urine with charcoal or C18 silica only partially reverses the HRP suppression. Inhibition of HRP in competitive assays biases results to the high side and in noncompetive assays biases results to the low side. The present findings suggest analysts should avoid immunoassay protocols that allow direct contact between undiluted urine and HRP reporter conjugates and should be cautious with quantitative results previously reported from assays that used undiluted urine with HRP reporters.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/48411859" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3e16c2026c0af80b9b98ba82e9580435" rel="nofollow" data-download="{"attachment_id":67057403,"asset_id":48411859,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/67057403/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="106087416" href="https://independent.academia.edu/ishfaqbashir3">ishfaq bashir</a><script data-card-contents-for-user="106087416" type="text/json">{"id":106087416,"first_name":"ishfaq","last_name":"bashir","domain_name":"independent","page_name":"ishfaqbashir3","display_name":"ishfaq bashir","profile_url":"https://independent.academia.edu/ishfaqbashir3?f_ri=2018875","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_48411859 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="48411859"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 48411859, container: ".js-paper-rank-work_48411859", }); });</script></li><li class="js-percentile-work_48411859 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48411859; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_48411859"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_48411859 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="48411859"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48411859; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48411859]").text(description); $(".js-view-count-work_48411859").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_48411859").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="48411859"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="140" rel="nofollow" href="https://www.academia.edu/Documents/in/Pharmacology">Pharmacology</a>, <script data-card-contents-for-ri="140" type="text/json">{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="145" rel="nofollow" href="https://www.academia.edu/Documents/in/Biochemistry">Biochemistry</a>, <script data-card-contents-for-ri="145" type="text/json">{"id":145,"name":"Biochemistry","url":"https://www.academia.edu/Documents/in/Biochemistry?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="226" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Psychology">Clinical Psychology</a>, <script data-card-contents-for-ri="226" type="text/json">{"id":226,"name":"Clinical Psychology","url":"https://www.academia.edu/Documents/in/Clinical_Psychology?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="260" rel="nofollow" href="https://www.academia.edu/Documents/in/Health_Psychology">Health Psychology</a><script data-card-contents-for-ri="260" type="text/json">{"id":260,"name":"Health Psychology","url":"https://www.academia.edu/Documents/in/Health_Psychology?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=48411859]'), work: {"id":48411859,"title":"Inhibition of Horseradish Peroxidase (HRP) by a Nonhydrophobic Component of Urine: A Caution for Immunoassays","created_at":"2021-05-04T17:44:02.889-07:00","url":"https://www.academia.edu/48411859/Inhibition_of_Horseradish_Peroxidase_HRP_by_a_Nonhydrophobic_Component_of_Urine_A_Caution_for_Immunoassays?f_ri=2018875","dom_id":"work_48411859","summary":"Undiluted urine mixed directly with HRP suppresses generation of enzyme product to less than 80% of that seen in buffer controls. Incubating dilutions of various urine preparations with HRP immobilized on concanavalin A coated microtiter plates reveals that the source of urine or HRP, and the type of HRP substrate used have minimal effect on the degree of HRP suppression; only dilutions of urine greater than 8-fold with buffer produce HRP activities equivalent to those in buffer. Treating urine with charcoal or C18 silica only partially reverses the HRP suppression. Inhibition of HRP in competitive assays biases results to the high side and in noncompetive assays biases results to the low side. The present findings suggest analysts should avoid immunoassay protocols that allow direct contact between undiluted urine and HRP reporter conjugates and should be cautious with quantitative results previously reported from assays that used undiluted urine with HRP reporters.","downloadable_attachments":[{"id":67057403,"asset_id":48411859,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":106087416,"first_name":"ishfaq","last_name":"bashir","domain_name":"independent","page_name":"ishfaqbashir3","display_name":"ishfaq bashir","profile_url":"https://independent.academia.edu/ishfaqbashir3?f_ri=2018875","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology?f_ri=2018875","nofollow":true},{"id":145,"name":"Biochemistry","url":"https://www.academia.edu/Documents/in/Biochemistry?f_ri=2018875","nofollow":true},{"id":226,"name":"Clinical Psychology","url":"https://www.academia.edu/Documents/in/Clinical_Psychology?f_ri=2018875","nofollow":true},{"id":260,"name":"Health Psychology","url":"https://www.academia.edu/Documents/in/Health_Psychology?f_ri=2018875","nofollow":true},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry?f_ri=2018875"},{"id":656,"name":"Pharmacy","url":"https://www.academia.edu/Documents/in/Pharmacy?f_ri=2018875"},{"id":5411,"name":"Biomass","url":"https://www.academia.edu/Documents/in/Biomass?f_ri=2018875"},{"id":51369,"name":"Functional Foods","url":"https://www.academia.edu/Documents/in/Functional_Foods?f_ri=2018875"},{"id":69430,"name":"Life Skills","url":"https://www.academia.edu/Documents/in/Life_Skills?f_ri=2018875"},{"id":185380,"name":"Optical Properties","url":"https://www.academia.edu/Documents/in/Optical_Properties?f_ri=2018875"},{"id":314240,"name":"Doxorubicin","url":"https://www.academia.edu/Documents/in/Doxorubicin?f_ri=2018875"},{"id":390049,"name":"Electrical Conductivity","url":"https://www.academia.edu/Documents/in/Electrical_Conductivity?f_ri=2018875"},{"id":414303,"name":"Magnetoresistance","url":"https://www.academia.edu/Documents/in/Magnetoresistance?f_ri=2018875"},{"id":736898,"name":"Hall effect","url":"https://www.academia.edu/Documents/in/Hall_effect?f_ri=2018875"},{"id":824508,"name":"Benzoxazoles","url":"https://www.academia.edu/Documents/in/Benzoxazoles?f_ri=2018875"},{"id":1634924,"name":"Butter","url":"https://www.academia.edu/Documents/in/Butter?f_ri=2018875"},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"},{"id":3157438,"name":"Molecular docking studies","url":"https://www.academia.edu/Documents/in/Molecular_docking_studies?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_33098229" data-work_id="33098229" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/33098229/EGFR_gene_regulation_in_colorectal_cancer_cells_by_garlic_phytocompounds_with_special_emphasis_on_S_Allyl_L_Cysteine_Sulfoxide">EGFR gene regulation in colorectal cancer cells by garlic phytocompounds with special emphasis on S-Allyl-L-Cysteine Sulfoxide</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Colorectal cancer is one among the most common cancers in the world and a major cause of cancer related deaths. Similar to other cancers, colorectal carcinogenesis is often associated with over expression of genes related to cell growth... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_33098229" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Colorectal cancer is one among the most common cancers in the world and a major cause of cancer related deaths. Similar to other cancers, colorectal carcinogenesis is often associated with over expression of genes related to cell growth and proliferation, especially Epidermal Growth Factor Receptor (EGFR). There is an increasing attention towards the plant derived compounds in prevention of colorectal carcinogenesis by downregulating EGFR. Among plants, garlic (Allium sativum L.) is emerging with anticancer properties by virtue of its organosulfur compounds. The present study was aimed to analyze the interaction ability of garlic compounds in the active region of EGFR gene by in silico molecular docking studies and in vitro validation. This was conducted using the Discovery studio software version 4.0. Among the tested compounds, s-allyl-l-cysteine-sulfoxide (SACS)/alliin showed higher affinity towards EGFR. Furthermore, wet lab analysis using cell viability test and EGFR expression analysis in colorectal cancer cells.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/33098229" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b2d67312cc888fbcbbfb343598b24f79" rel="nofollow" data-download="{"attachment_id":53196059,"asset_id":33098229,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/53196059/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="24615833" href="https://independent.academia.edu/ArunaksharanN">Arunaksharan N</a><script data-card-contents-for-user="24615833" type="text/json">{"id":24615833,"first_name":"Arunaksharan","last_name":"N","domain_name":"independent","page_name":"ArunaksharanN","display_name":"Arunaksharan N","profile_url":"https://independent.academia.edu/ArunaksharanN?f_ri=2018875","photo":"https://0.academia-photos.com/24615833/6657923/17030675/s65_arunaksharan.n.png"}</script></span></span></li><li class="js-paper-rank-work_33098229 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="33098229"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 33098229, container: ".js-paper-rank-work_33098229", }); });</script></li><li class="js-percentile-work_33098229 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 33098229; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_33098229"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_33098229 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="33098229"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 33098229; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=33098229]").text(description); $(".js-view-count-work_33098229").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_33098229").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="33098229"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="51700" rel="nofollow" href="https://www.academia.edu/Documents/in/EGFR">EGFR</a>, <script data-card-contents-for-ri="51700" type="text/json">{"id":51700,"name":"EGFR","url":"https://www.academia.edu/Documents/in/EGFR?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="269567" rel="nofollow" href="https://www.academia.edu/Documents/in/Garlic">Garlic</a>, <script data-card-contents-for-ri="269567" type="text/json">{"id":269567,"name":"Garlic","url":"https://www.academia.edu/Documents/in/Garlic?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="420802" rel="nofollow" href="https://www.academia.edu/Documents/in/Colon_cancer">Colon cancer</a>, <script data-card-contents-for-ri="420802" type="text/json">{"id":420802,"name":"Colon cancer","url":"https://www.academia.edu/Documents/in/Colon_cancer?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="865697" rel="nofollow" href="https://www.academia.edu/Documents/in/In_Silico">In Silico</a><script data-card-contents-for-ri="865697" type="text/json">{"id":865697,"name":"In Silico","url":"https://www.academia.edu/Documents/in/In_Silico?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=33098229]'), work: {"id":33098229,"title":"EGFR gene regulation in colorectal cancer cells by garlic phytocompounds with special emphasis on S-Allyl-L-Cysteine Sulfoxide","created_at":"2017-05-19T07:11:56.647-07:00","url":"https://www.academia.edu/33098229/EGFR_gene_regulation_in_colorectal_cancer_cells_by_garlic_phytocompounds_with_special_emphasis_on_S_Allyl_L_Cysteine_Sulfoxide?f_ri=2018875","dom_id":"work_33098229","summary":"Colorectal cancer is one among the most common cancers in the world and a major cause of cancer related deaths. Similar to other cancers, colorectal carcinogenesis is often associated with over expression of genes related to cell growth and proliferation, especially Epidermal Growth Factor Receptor (EGFR). There is an increasing attention towards the plant derived compounds in prevention of colorectal carcinogenesis by downregulating EGFR. Among plants, garlic (Allium sativum L.) is emerging with anticancer properties by virtue of its organosulfur compounds. The present study was aimed to analyze the interaction ability of garlic compounds in the active region of EGFR gene by in silico molecular docking studies and in vitro validation. This was conducted using the Discovery studio software version 4.0. Among the tested compounds, s-allyl-l-cysteine-sulfoxide (SACS)/alliin showed higher affinity towards EGFR. Furthermore, wet lab analysis using cell viability test and EGFR expression analysis in colorectal cancer cells.","downloadable_attachments":[{"id":53196059,"asset_id":33098229,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":24615833,"first_name":"Arunaksharan","last_name":"N","domain_name":"independent","page_name":"ArunaksharanN","display_name":"Arunaksharan N","profile_url":"https://independent.academia.edu/ArunaksharanN?f_ri=2018875","photo":"https://0.academia-photos.com/24615833/6657923/17030675/s65_arunaksharan.n.png"}],"research_interests":[{"id":51700,"name":"EGFR","url":"https://www.academia.edu/Documents/in/EGFR?f_ri=2018875","nofollow":true},{"id":269567,"name":"Garlic","url":"https://www.academia.edu/Documents/in/Garlic?f_ri=2018875","nofollow":true},{"id":420802,"name":"Colon cancer","url":"https://www.academia.edu/Documents/in/Colon_cancer?f_ri=2018875","nofollow":true},{"id":865697,"name":"In Silico","url":"https://www.academia.edu/Documents/in/In_Silico?f_ri=2018875","nofollow":true},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_77847969" data-work_id="77847969" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/77847969/Novel_Pyrazolyl_Benzoxazole_Conjugates_Design_Synthesis_Molecular_Docking_Studies_and_in_vitro_Anticancer_Activities">Novel Pyrazolyl Benzoxazole Conjugates: Design, Synthesis, Molecular Docking Studies and in vitro Anticancer Activities</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Nowadays, hybrid drugs have gained a significant role in the treatment of different health problems. Most of the hybrid molecules with different heterocyclic moieties were proved to be potent anti-tumor agents in cancer chemotherapy.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_77847969" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Nowadays, hybrid drugs have gained a significant role in the treatment of different health problems. Most of the hybrid molecules with different heterocyclic moieties were proved to be potent anti-tumor agents in cancer chemotherapy. Hence, the present study is aimed at the evaluation of in vitro anticancer activity of novel hybrid molecules (pyrazolyl benzoxazole conjugates) and to investigate their anticancer activity by molecular docking studies. Designed, synthesized and characterized the novel pyrazolyl benzoxazole conjugates. Anticancer activity of these compounds was determined by SRB assay. Then molecular docking studies were carried out against proto-oncogene tyrosine-protein kinase (ATP-Src, PDB: 2BDF), a putative target for cancer. All the synthesized compound derivatives were evaluated against MCF-7, KB, Hop62 and A549 cancer cell lines. Compounds 9b and 9c exhibited excellent anticancer activities with GI50 values of &lt;0.1 µM against MCF-7 and A549 cell lines. Compoun...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/77847969" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="bc718b7707ed31b888d05285d4af39ab" rel="nofollow" data-download="{"attachment_id":85099297,"asset_id":77847969,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/85099297/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="64940295" href="https://independent.academia.edu/NarayanaGanta">Narayana Ganta</a><script data-card-contents-for-user="64940295" type="text/json">{"id":64940295,"first_name":"Narayana","last_name":"Ganta","domain_name":"independent","page_name":"NarayanaGanta","display_name":"Narayana Ganta","profile_url":"https://independent.academia.edu/NarayanaGanta?f_ri=2018875","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_77847969 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="77847969"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 77847969, container: ".js-paper-rank-work_77847969", }); });</script></li><li class="js-percentile-work_77847969 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 77847969; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_77847969"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_77847969 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="77847969"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 77847969; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=77847969]").text(description); $(".js-view-count-work_77847969").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_77847969").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="77847969"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">6</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="531" rel="nofollow" href="https://www.academia.edu/Documents/in/Organic_Chemistry">Organic Chemistry</a>, <script data-card-contents-for-ri="531" type="text/json">{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="314240" rel="nofollow" href="https://www.academia.edu/Documents/in/Doxorubicin">Doxorubicin</a>, <script data-card-contents-for-ri="314240" type="text/json">{"id":314240,"name":"Doxorubicin","url":"https://www.academia.edu/Documents/in/Doxorubicin?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="801412" rel="nofollow" href="https://www.academia.edu/Documents/in/Pyrazoles">Pyrazoles</a>, <script data-card-contents-for-ri="801412" type="text/json">{"id":801412,"name":"Pyrazoles","url":"https://www.academia.edu/Documents/in/Pyrazoles?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="824508" rel="nofollow" href="https://www.academia.edu/Documents/in/Benzoxazoles">Benzoxazoles</a><script data-card-contents-for-ri="824508" type="text/json">{"id":824508,"name":"Benzoxazoles","url":"https://www.academia.edu/Documents/in/Benzoxazoles?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=77847969]'), work: {"id":77847969,"title":"Novel Pyrazolyl Benzoxazole Conjugates: Design, Synthesis, Molecular Docking Studies and in vitro Anticancer Activities","created_at":"2022-04-28T01:31:38.504-07:00","url":"https://www.academia.edu/77847969/Novel_Pyrazolyl_Benzoxazole_Conjugates_Design_Synthesis_Molecular_Docking_Studies_and_in_vitro_Anticancer_Activities?f_ri=2018875","dom_id":"work_77847969","summary":"Nowadays, hybrid drugs have gained a significant role in the treatment of different health problems. Most of the hybrid molecules with different heterocyclic moieties were proved to be potent anti-tumor agents in cancer chemotherapy. Hence, the present study is aimed at the evaluation of in vitro anticancer activity of novel hybrid molecules (pyrazolyl benzoxazole conjugates) and to investigate their anticancer activity by molecular docking studies. Designed, synthesized and characterized the novel pyrazolyl benzoxazole conjugates. Anticancer activity of these compounds was determined by SRB assay. Then molecular docking studies were carried out against proto-oncogene tyrosine-protein kinase (ATP-Src, PDB: 2BDF), a putative target for cancer. All the synthesized compound derivatives were evaluated against MCF-7, KB, Hop62 and A549 cancer cell lines. Compounds 9b and 9c exhibited excellent anticancer activities with GI50 values of \u0026lt;0.1 µM against MCF-7 and A549 cell lines. Compoun...","downloadable_attachments":[{"id":85099297,"asset_id":77847969,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":64940295,"first_name":"Narayana","last_name":"Ganta","domain_name":"independent","page_name":"NarayanaGanta","display_name":"Narayana Ganta","profile_url":"https://independent.academia.edu/NarayanaGanta?f_ri=2018875","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry?f_ri=2018875","nofollow":true},{"id":314240,"name":"Doxorubicin","url":"https://www.academia.edu/Documents/in/Doxorubicin?f_ri=2018875","nofollow":true},{"id":801412,"name":"Pyrazoles","url":"https://www.academia.edu/Documents/in/Pyrazoles?f_ri=2018875","nofollow":true},{"id":824508,"name":"Benzoxazoles","url":"https://www.academia.edu/Documents/in/Benzoxazoles?f_ri=2018875","nofollow":true},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"},{"id":3157438,"name":"Molecular docking studies","url":"https://www.academia.edu/Documents/in/Molecular_docking_studies?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_59131293" data-work_id="59131293" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/59131293/Synthesis_and_cyclization_of_%CE%B2_keto_enol_derivatives_tethered_indole_and_pyrazole_as_potential_antimicrobial_and_anticancer_activity">Synthesis and cyclization of β-keto-enol derivatives tethered indole and pyrazole as potential antimicrobial and anticancer activity</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Synthesis of biologically active new indole and pyrazole derivatives has earned a substantial position in the pharmaceutical industry. The study aims to synthesize and cyclize β-keto-enol derivatives tethered indole and pyrazole as... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_59131293" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Synthesis of biologically active new indole and pyrazole derivatives has earned a substantial position in the pharmaceutical industry. The study aims to synthesize and cyclize β-keto-enol derivatives tethered indole and pyrazole as potential antimicrobial and anticancer activity. Novel derivatives of enolic keto ester 1 have been obtained through Claisen condensation of 3-acetylindole with diethyl oxalate under basic conditions. Spectral data of newly produced compounds were characterized using Fourier transform infrared, hydrogen nuclear magnetic resonance, Carbon-13 nuclear magnetic resonance, and elemental analysis. Few compounds were assessed for their antimicrobial activity, contrary to gram-positive bacterial strains, gram-negative bacterial strain, and antifungal activity that have been approved against Candida albicans. However, compound 2 showed an excellent antimicrobial activity. In vitro antitumor action of few prepared compounds in contradiction to human breast carcinoma cell line, colon cell line, and normal retina cell line was evaluated.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/59131293" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e1dc83929fd057ed62376fa487b165a4" rel="nofollow" data-download="{"attachment_id":73213228,"asset_id":59131293,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/73213228/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42411691" href="https://independent.academia.edu/GehanElBassyouni">Gehan T . El-Bassyouni</a><script data-card-contents-for-user="42411691" type="text/json">{"id":42411691,"first_name":"Gehan","last_name":"El-Bassyouni","domain_name":"independent","page_name":"GehanElBassyouni","display_name":"Gehan T . El-Bassyouni","profile_url":"https://independent.academia.edu/GehanElBassyouni?f_ri=2018875","photo":"https://0.academia-photos.com/42411691/11428243/12747377/s65_gehan.el-bassyouni.jpg"}</script></span></span></li><li class="js-paper-rank-work_59131293 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="59131293"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 59131293, container: ".js-paper-rank-work_59131293", }); });</script></li><li class="js-percentile-work_59131293 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 59131293; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_59131293"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_59131293 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="59131293"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 59131293; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=59131293]").text(description); $(".js-view-count-work_59131293").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_59131293").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="59131293"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="111007" rel="nofollow" href="https://www.academia.edu/Documents/in/Antimicrobial_activity">Antimicrobial activity</a>, <script data-card-contents-for-ri="111007" type="text/json">{"id":111007,"name":"Antimicrobial activity","url":"https://www.academia.edu/Documents/in/Antimicrobial_activity?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="619973" rel="nofollow" href="https://www.academia.edu/Documents/in/Indole">Indole</a>, <script data-card-contents-for-ri="619973" type="text/json">{"id":619973,"name":"Indole","url":"https://www.academia.edu/Documents/in/Indole?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="801412" rel="nofollow" href="https://www.academia.edu/Documents/in/Pyrazoles">Pyrazoles</a>, <script data-card-contents-for-ri="801412" type="text/json">{"id":801412,"name":"Pyrazoles","url":"https://www.academia.edu/Documents/in/Pyrazoles?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2018875" rel="nofollow" href="https://www.academia.edu/Documents/in/Anticancer_activity">Anticancer activity</a><script data-card-contents-for-ri="2018875" type="text/json">{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=59131293]'), work: {"id":59131293,"title":"Synthesis and cyclization of β-keto-enol derivatives tethered indole and pyrazole as potential antimicrobial and anticancer activity","created_at":"2021-10-20T09:58:07.449-07:00","url":"https://www.academia.edu/59131293/Synthesis_and_cyclization_of_%CE%B2_keto_enol_derivatives_tethered_indole_and_pyrazole_as_potential_antimicrobial_and_anticancer_activity?f_ri=2018875","dom_id":"work_59131293","summary":"Synthesis of biologically active new indole and pyrazole derivatives has earned a substantial position in the pharmaceutical industry. The study aims to synthesize and cyclize β-keto-enol derivatives tethered indole and pyrazole as potential antimicrobial and anticancer activity. Novel derivatives of enolic keto ester 1 have been obtained through Claisen condensation of 3-acetylindole with diethyl oxalate under basic conditions. Spectral data of newly produced compounds were characterized using Fourier transform infrared, hydrogen nuclear magnetic resonance, Carbon-13 nuclear magnetic resonance, and elemental analysis. Few compounds were assessed for their antimicrobial activity, contrary to gram-positive bacterial strains, gram-negative bacterial strain, and antifungal activity that have been approved against Candida albicans. However, compound 2 showed an excellent antimicrobial activity. In vitro antitumor action of few prepared compounds in contradiction to human breast carcinoma cell line, colon cell line, and normal retina cell line was evaluated.","downloadable_attachments":[{"id":73213228,"asset_id":59131293,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42411691,"first_name":"Gehan","last_name":"El-Bassyouni","domain_name":"independent","page_name":"GehanElBassyouni","display_name":"Gehan T . El-Bassyouni","profile_url":"https://independent.academia.edu/GehanElBassyouni?f_ri=2018875","photo":"https://0.academia-photos.com/42411691/11428243/12747377/s65_gehan.el-bassyouni.jpg"}],"research_interests":[{"id":111007,"name":"Antimicrobial activity","url":"https://www.academia.edu/Documents/in/Antimicrobial_activity?f_ri=2018875","nofollow":true},{"id":619973,"name":"Indole","url":"https://www.academia.edu/Documents/in/Indole?f_ri=2018875","nofollow":true},{"id":801412,"name":"Pyrazoles","url":"https://www.academia.edu/Documents/in/Pyrazoles?f_ri=2018875","nofollow":true},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_54527037" data-work_id="54527037" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/54527037/Synthesis_Molecular_Docking_and_Anticancer_Activity_of_Novel_1_3_Thiazolidin_4_Ones">Synthesis, Molecular Docking and Anticancer Activity of Novel 1,3-Thiazolidin-4-Ones</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Cancer is a major cause of death all over the globe. Controlling cell division by inhibition of mitosis is the most successful clinical strategy for cancer treatment. The development of novel anticancer agents is the most... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_54527037" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Cancer is a major cause of death all over the globe. Controlling cell division by inhibition of mitosis is the most successful clinical strategy for cancer treatment. The development of novel anticancer agents is the most important area in medicinal chemistry and drug discovery research. Thiazolidine is the multifunctional nucleus which shows a number of pharmacological activities like anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, antidiabetic, antihyperlipidemic and antiarthritic. Methods: In a present study series of 2-substituted-3-(1H-benzimidazole-2-yl)-thiazolidin-4-ones were designed, synthesized by the microwave-assisted system, and characterized by melting point, IR, 1 H NMR, and mass spectroscopy. All the newly synthesized compounds were examined for their in vitro anticancer activity against breast cancer cell line MCF-7 by Sulforhodamine B (SRB) assay. Results: The compounds AB-12 (GI 50 : 28.5 µg/ml) and AB-6 (GI 50 : 50.7 µg/ml) exhibited significant cell growth inhibitory activity. Conclusion: These results indicate that compound AB-12 and AB-6 as related polo-like kinase 1inhibitors compounds could be lead compounds for further development of anticancer agents.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/54527037" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6b34b4ef907134994231304dfea4204a" rel="nofollow" data-download="{"attachment_id":70849601,"asset_id":54527037,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/70849601/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="54514119" href="https://unipune.academia.edu/GaneshBarkade">Prof. Ganesh D . Barkade</a><script data-card-contents-for-user="54514119" type="text/json">{"id":54514119,"first_name":"Prof. Ganesh","last_name":"Barkade","domain_name":"unipune","page_name":"GaneshBarkade","display_name":"Prof. Ganesh D . Barkade","profile_url":"https://unipune.academia.edu/GaneshBarkade?f_ri=2018875","photo":"https://0.academia-photos.com/54514119/37337388/31630763/s65_ganesh.barkade.jpg"}</script></span></span></li><li class="js-paper-rank-work_54527037 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="54527037"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 54527037, container: ".js-paper-rank-work_54527037", }); });</script></li><li class="js-percentile-work_54527037 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 54527037; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_54527037"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_54527037 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="54527037"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 54527037; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=54527037]").text(description); $(".js-view-count-work_54527037").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_54527037").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="54527037"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="2375" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicinal_Chemistry">Medicinal Chemistry</a>, <script data-card-contents-for-ri="2375" type="text/json">{"id":2375,"name":"Medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Medicinal_Chemistry?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="55388" rel="nofollow" href="https://www.academia.edu/Documents/in/Organic_Synthesis">Organic Synthesis</a>, <script data-card-contents-for-ri="55388" type="text/json">{"id":55388,"name":"Organic Synthesis","url":"https://www.academia.edu/Documents/in/Organic_Synthesis?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="141235" rel="nofollow" href="https://www.academia.edu/Documents/in/Molecular_docking">Molecular docking</a>, <script data-card-contents-for-ri="141235" type="text/json">{"id":141235,"name":"Molecular docking","url":"https://www.academia.edu/Documents/in/Molecular_docking?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2018875" rel="nofollow" href="https://www.academia.edu/Documents/in/Anticancer_activity">Anticancer activity</a><script data-card-contents-for-ri="2018875" type="text/json">{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=54527037]'), work: {"id":54527037,"title":"Synthesis, Molecular Docking and Anticancer Activity of Novel 1,3-Thiazolidin-4-Ones","created_at":"2021-10-01T02:02:02.196-07:00","url":"https://www.academia.edu/54527037/Synthesis_Molecular_Docking_and_Anticancer_Activity_of_Novel_1_3_Thiazolidin_4_Ones?f_ri=2018875","dom_id":"work_54527037","summary":"Background: Cancer is a major cause of death all over the globe. Controlling cell division by inhibition of mitosis is the most successful clinical strategy for cancer treatment. The development of novel anticancer agents is the most important area in medicinal chemistry and drug discovery research. Thiazolidine is the multifunctional nucleus which shows a number of pharmacological activities like anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, antidiabetic, antihyperlipidemic and antiarthritic. Methods: In a present study series of 2-substituted-3-(1H-benzimidazole-2-yl)-thiazolidin-4-ones were designed, synthesized by the microwave-assisted system, and characterized by melting point, IR, 1 H NMR, and mass spectroscopy. All the newly synthesized compounds were examined for their in vitro anticancer activity against breast cancer cell line MCF-7 by Sulforhodamine B (SRB) assay. Results: The compounds AB-12 (GI 50 : 28.5 µg/ml) and AB-6 (GI 50 : 50.7 µg/ml) exhibited significant cell growth inhibitory activity. Conclusion: These results indicate that compound AB-12 and AB-6 as related polo-like kinase 1inhibitors compounds could be lead compounds for further development of anticancer agents.","downloadable_attachments":[{"id":70849601,"asset_id":54527037,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":54514119,"first_name":"Prof. Ganesh","last_name":"Barkade","domain_name":"unipune","page_name":"GaneshBarkade","display_name":"Prof. Ganesh D . Barkade","profile_url":"https://unipune.academia.edu/GaneshBarkade?f_ri=2018875","photo":"https://0.academia-photos.com/54514119/37337388/31630763/s65_ganesh.barkade.jpg"}],"research_interests":[{"id":2375,"name":"Medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Medicinal_Chemistry?f_ri=2018875","nofollow":true},{"id":55388,"name":"Organic Synthesis","url":"https://www.academia.edu/Documents/in/Organic_Synthesis?f_ri=2018875","nofollow":true},{"id":141235,"name":"Molecular docking","url":"https://www.academia.edu/Documents/in/Molecular_docking?f_ri=2018875","nofollow":true},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_43898149" data-work_id="43898149" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/43898149/Evaluation_of_the_Phytochemical_Antioxidant_Antibacterial_and_Anticancer_Activity_of_Prunus_domestica_Fruit">Evaluation of the Phytochemical, Antioxidant, Antibacterial and Anticancer Activity of Prunus domestica Fruit</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Plants have been used long ago through man history of life for their use in food and medicinal drives. In modern life, natural products have been extracted and isolated from several kinds of plants for the development of new drugs. There... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_43898149" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Plants have been used long ago through man history of life for their use in food and medicinal drives. In modern life, natural products have been extracted and isolated from several kinds of plants for the development of new drugs. There are numerous interests in natural antioxidants extracted from medicinal plants, vegetables and fruits, which might help to prevent oxidative damage. One of such plants is plum Prunus domestica L., family Rosaceae. Samples from 'African Rose', and 'Santa Rosa' plum cultivars were collected from local market in Giza governorate, Egypt. The main phytochemicals of plums (fruit flesh and skin) were analyzed. Total polyphenols, flavonoids, tannins, anthocyanins, and reducing power were higher in 'African Rose' fruit. The ethanolic and ethyl acetate extracts of two plum cultivars were both high in the antioxidant effect with IC50 13.923 and 18.416 μg/ml of ethanolic extract of 'African Rose', and 'Santa Rosa' respectively. The IC50 of 'African Rose' and 'Santa Rose' extract against Caco-2 was 4 and 8.5 μg/ml. GC-MS analysis was carried out, fourteen and twenty one compound were identified in 'Santa Rosa' and 'African Rose' respectively. The fruits had an antimicrobial action against gram positive and negative bacteria. There was anticancer activity against 3 cell lines: Liver cell line (HepG2), colorectal adenocarcinoma (Caco-2) cell line, and breast cell line (MCF-7).</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/43898149" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="080dc1fb71e5f612730e5b64fe792501" rel="nofollow" data-download="{"attachment_id":64221438,"asset_id":43898149,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/64221438/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33397819" href="https://cambridge.academia.edu/GehanSafwat">Gehan Safwat</a><script data-card-contents-for-user="33397819" type="text/json">{"id":33397819,"first_name":"Gehan","last_name":"Safwat","domain_name":"cambridge","page_name":"GehanSafwat","display_name":"Gehan Safwat","profile_url":"https://cambridge.academia.edu/GehanSafwat?f_ri=2018875","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_43898149 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="43898149"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 43898149, container: ".js-paper-rank-work_43898149", }); });</script></li><li class="js-percentile-work_43898149 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43898149; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_43898149"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_43898149 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="43898149"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43898149; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43898149]").text(description); $(".js-view-count-work_43898149").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_43898149").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="43898149"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="103339" rel="nofollow" href="https://www.academia.edu/Documents/in/Antioxidant">Antioxidant</a>, <script data-card-contents-for-ri="103339" type="text/json">{"id":103339,"name":"Antioxidant","url":"https://www.academia.edu/Documents/in/Antioxidant?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="347988" rel="nofollow" href="https://www.academia.edu/Documents/in/Phenols">Phenols</a>, <script data-card-contents-for-ri="347988" type="text/json">{"id":347988,"name":"Phenols","url":"https://www.academia.edu/Documents/in/Phenols?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="382472" rel="nofollow" href="https://www.academia.edu/Documents/in/DPPH">DPPH</a>, <script data-card-contents-for-ri="382472" type="text/json">{"id":382472,"name":"DPPH","url":"https://www.academia.edu/Documents/in/DPPH?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="913998" rel="nofollow" href="https://www.academia.edu/Documents/in/Antibacterial">Antibacterial</a><script data-card-contents-for-ri="913998" type="text/json">{"id":913998,"name":"Antibacterial","url":"https://www.academia.edu/Documents/in/Antibacterial?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=43898149]'), work: {"id":43898149,"title":"Evaluation of the Phytochemical, Antioxidant, Antibacterial and Anticancer Activity of Prunus domestica Fruit","created_at":"2020-08-19T07:39:22.863-07:00","url":"https://www.academia.edu/43898149/Evaluation_of_the_Phytochemical_Antioxidant_Antibacterial_and_Anticancer_Activity_of_Prunus_domestica_Fruit?f_ri=2018875","dom_id":"work_43898149","summary":"Plants have been used long ago through man history of life for their use in food and medicinal drives. In modern life, natural products have been extracted and isolated from several kinds of plants for the development of new drugs. There are numerous interests in natural antioxidants extracted from medicinal plants, vegetables and fruits, which might help to prevent oxidative damage. One of such plants is plum Prunus domestica L., family Rosaceae. Samples from 'African Rose', and 'Santa Rosa' plum cultivars were collected from local market in Giza governorate, Egypt. The main phytochemicals of plums (fruit flesh and skin) were analyzed. Total polyphenols, flavonoids, tannins, anthocyanins, and reducing power were higher in 'African Rose' fruit. The ethanolic and ethyl acetate extracts of two plum cultivars were both high in the antioxidant effect with IC50 13.923 and 18.416 μg/ml of ethanolic extract of 'African Rose', and 'Santa Rosa' respectively. The IC50 of 'African Rose' and 'Santa Rose' extract against Caco-2 was 4 and 8.5 μg/ml. GC-MS analysis was carried out, fourteen and twenty one compound were identified in 'Santa Rosa' and 'African Rose' respectively. The fruits had an antimicrobial action against gram positive and negative bacteria. There was anticancer activity against 3 cell lines: Liver cell line (HepG2), colorectal adenocarcinoma (Caco-2) cell line, and breast cell line (MCF-7).\n","downloadable_attachments":[{"id":64221438,"asset_id":43898149,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33397819,"first_name":"Gehan","last_name":"Safwat","domain_name":"cambridge","page_name":"GehanSafwat","display_name":"Gehan Safwat","profile_url":"https://cambridge.academia.edu/GehanSafwat?f_ri=2018875","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":103339,"name":"Antioxidant","url":"https://www.academia.edu/Documents/in/Antioxidant?f_ri=2018875","nofollow":true},{"id":347988,"name":"Phenols","url":"https://www.academia.edu/Documents/in/Phenols?f_ri=2018875","nofollow":true},{"id":382472,"name":"DPPH","url":"https://www.academia.edu/Documents/in/DPPH?f_ri=2018875","nofollow":true},{"id":913998,"name":"Antibacterial","url":"https://www.academia.edu/Documents/in/Antibacterial?f_ri=2018875","nofollow":true},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_40766210" data-work_id="40766210" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/40766210/Novel_1_3_4_Thiadiazole_Linked_Amide_Derivatives_of_Pteridone_Synthesis_and_Study_of_Anticancer_Activities">Novel 1,3,4-Thiadiazole Linked Amide Derivatives of Pteridone: Synthesis and Study of Anticancer Activities</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Cancer is a second leading cause of death after heart attack, in developing as well as undeveloped countries. It is caused by unregulated growth and metastasis of the abnormal cancer cells. Cancer can be cured by radiation, immunotherapy... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_40766210" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Cancer is a second leading cause of death after heart attack, in developing as well as undeveloped countries. It is caused by unregulated growth and metastasis of the abnormal cancer cells. Cancer can be cured by radiation, immunotherapy and chemotherapy, among them; chemotherapy is a good treatment for cancer, in which chemotherapeutic drug is used. The anticancer activity of newly synthesized compounds (13a-j) was carried out on four different types of human cancer cell lines like MCF-7 (breast), A549 (lung), Colo-205 (colon) and A2780 (ovarian) by the MTT method, and compared to etoposide used as a positive control. Among them, compound 13g with electron-withdrawing (3,5-dinitro) group, exhibited more promising activity in all cell lines (MCF-7 = 0.10±0.076 µM, A549 = 0.17±0.039 µM, Colo-205= 0.13±0.022 µM and A2780 = 0.87±0.027µM). This compound may act as lead drug in cancer chemotherapy. In future, this compound can be examined for clinical studies.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/40766210" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="70400efb30454418a5c02dc6135d2456" rel="nofollow" data-download="{"attachment_id":61046449,"asset_id":40766210,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/61046449/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="5803185" href="https://independent.academia.edu/RatnakaramVenkataNadh">Ratnakaram Venkata Nadh</a><script data-card-contents-for-user="5803185" type="text/json">{"id":5803185,"first_name":"Ratnakaram","last_name":"Venkata Nadh","domain_name":"independent","page_name":"RatnakaramVenkataNadh","display_name":"Ratnakaram Venkata Nadh","profile_url":"https://independent.academia.edu/RatnakaramVenkataNadh?f_ri=2018875","photo":"https://0.academia-photos.com/5803185/29204422/27207733/s65_ratnakaram.venkata_nadh.jpg"}</script></span></span></li><li class="js-paper-rank-work_40766210 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="40766210"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 40766210, container: ".js-paper-rank-work_40766210", }); 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$(".js-view-count[data-work-id=40766210]").text(description); $(".js-view-count-work_40766210").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_40766210").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="40766210"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="1629947" rel="nofollow" href="https://www.academia.edu/Documents/in/Thiamethoxam">Thiamethoxam</a>, <script data-card-contents-for-ri="1629947" type="text/json">{"id":1629947,"name":"Thiamethoxam","url":"https://www.academia.edu/Documents/in/Thiamethoxam?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2018875" rel="nofollow" href="https://www.academia.edu/Documents/in/Anticancer_activity">Anticancer activity</a>, <script data-card-contents-for-ri="2018875" type="text/json">{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3426821" rel="nofollow" href="https://www.academia.edu/Documents/in/Triamterene">Triamterene</a><script data-card-contents-for-ri="3426821" type="text/json">{"id":3426821,"name":"Triamterene","url":"https://www.academia.edu/Documents/in/Triamterene?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=40766210]'), work: {"id":40766210,"title":"Novel 1,3,4-Thiadiazole Linked Amide Derivatives of Pteridone: Synthesis and Study of Anticancer Activities","created_at":"2019-10-28T08:28:10.764-07:00","url":"https://www.academia.edu/40766210/Novel_1_3_4_Thiadiazole_Linked_Amide_Derivatives_of_Pteridone_Synthesis_and_Study_of_Anticancer_Activities?f_ri=2018875","dom_id":"work_40766210","summary":"Cancer is a second leading cause of death after heart attack, in developing as well as undeveloped countries. It is caused by unregulated growth and metastasis of the abnormal cancer cells. Cancer can be cured by radiation, immunotherapy and chemotherapy, among them; chemotherapy is a good treatment for cancer, in which chemotherapeutic drug is used. The anticancer activity of newly synthesized compounds (13a-j) was carried out on four different types of human cancer cell lines like MCF-7 (breast), A549 (lung), Colo-205 (colon) and A2780 (ovarian) by the MTT method, and compared to etoposide used as a positive control. Among them, compound 13g with electron-withdrawing (3,5-dinitro) group, exhibited more promising activity in all cell lines (MCF-7 = 0.10±0.076 µM, A549 = 0.17±0.039 µM, Colo-205= 0.13±0.022 µM and A2780 = 0.87±0.027µM). This compound may act as lead drug in cancer chemotherapy. In future, this compound can be examined for clinical studies.","downloadable_attachments":[{"id":61046449,"asset_id":40766210,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":5803185,"first_name":"Ratnakaram","last_name":"Venkata Nadh","domain_name":"independent","page_name":"RatnakaramVenkataNadh","display_name":"Ratnakaram Venkata Nadh","profile_url":"https://independent.academia.edu/RatnakaramVenkataNadh?f_ri=2018875","photo":"https://0.academia-photos.com/5803185/29204422/27207733/s65_ratnakaram.venkata_nadh.jpg"}],"research_interests":[{"id":1629947,"name":"Thiamethoxam","url":"https://www.academia.edu/Documents/in/Thiamethoxam?f_ri=2018875","nofollow":true},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true},{"id":3426821,"name":"Triamterene","url":"https://www.academia.edu/Documents/in/Triamterene?f_ri=2018875","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_38521413" data-work_id="38521413" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/38521413/Send_Orders_for_Reprints_to_reprints_at_benthamscience_ae_Letters_in_Organic_Novel_Pyrazolyl_Benzoxazole_Conjugates_Design_Synthesis_Molecular_Docking_Studies_and_in_vitro_Anticancer_Activities">Send Orders for Reprints to reprints@benthamscience.ae Letters in Organic Novel Pyrazolyl Benzoxazole Conjugates: Design, Synthesis, Molecular Docking Studies and in vitro Anticancer Activities</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Nowadays, hybrid drugs have gained a significant role in the treatment of different health problems. Most of the hybrid molecules with different heterocyclic moieties were proved to be potent anti-tumor agents in cancer... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_38521413" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Nowadays, hybrid drugs have gained a significant role in the treatment of different health problems. Most of the hybrid molecules with different heterocyclic moieties were proved to be potent anti-tumor agents in cancer chemotherapy. Hence, the present study is aimed at the evaluation of in vitro anticancer activity of novel hybrid molecules (pyrazolyl benzoxazole conjugates) and to investigate their anticancer activity by molecular docking studies. Methods: Designed, synthesized and characterized the novel pyrazolyl benzoxazole conjugates. Anticancer activity of these compounds was determined by SRB assay. Then molecular docking studies were carried out against proto-oncogene tyrosine-protein kinase (ATP-Src, PDB: 2BDF), a putative target for cancer. Results: All the synthesized compound derivatives were evaluated against MCF-7, KB, Hop62 and A549 cancer cell lines. Compounds 9b and 9c exhibited excellent anticancer activities with GI 50 values of <0.1 µM against MCF-7 and A549 cell lines. Compound 9e exhibited good antitumor activity on MCF-7 and A-549 with GI 50 values of 0.12 µM and 0.19 µM respectively. Compound 9g showed better anticancer activity on A-549 cancer cell line with GI 50 value of 0.34 µM. Conclusion: The two-hybrid molecules 9b and 9c are found to be comparably potent with the standard drug doxorubicin and may act as drug lead compounds in medicinal chemistry aspect. The present docking investigation proved that having benzoxazole of compound 9c at benzofuran of reference compound N-acetyl pyrazoline derivative might be valid for contributing to anti-cancer activity.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/38521413" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="621f471de3064ceda754208f857ea68e" rel="nofollow" data-download="{"attachment_id":58590183,"asset_id":38521413,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/58590183/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="14607322" href="https://gitam.academia.edu/RatnakaramVenkataNadh">Ratnakaram Venkata Nadh</a><script data-card-contents-for-user="14607322" type="text/json">{"id":14607322,"first_name":"Ratnakaram","last_name":"Venkata Nadh","domain_name":"gitam","page_name":"RatnakaramVenkataNadh","display_name":"Ratnakaram Venkata Nadh","profile_url":"https://gitam.academia.edu/RatnakaramVenkataNadh?f_ri=2018875","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_38521413 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="38521413"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 38521413, container: ".js-paper-rank-work_38521413", }); 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$(".js-view-count[data-work-id=38521413]").text(description); $(".js-view-count-work_38521413").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_38521413").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="38521413"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="314240" rel="nofollow" href="https://www.academia.edu/Documents/in/Doxorubicin">Doxorubicin</a>, <script data-card-contents-for-ri="314240" type="text/json">{"id":314240,"name":"Doxorubicin","url":"https://www.academia.edu/Documents/in/Doxorubicin?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="824508" rel="nofollow" href="https://www.academia.edu/Documents/in/Benzoxazoles">Benzoxazoles</a>, <script data-card-contents-for-ri="824508" type="text/json">{"id":824508,"name":"Benzoxazoles","url":"https://www.academia.edu/Documents/in/Benzoxazoles?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="956327" rel="nofollow" href="https://www.academia.edu/Documents/in/Pyrazole">Pyrazole</a>, <script data-card-contents-for-ri="956327" type="text/json">{"id":956327,"name":"Pyrazole","url":"https://www.academia.edu/Documents/in/Pyrazole?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2018875" rel="nofollow" href="https://www.academia.edu/Documents/in/Anticancer_activity">Anticancer activity</a><script data-card-contents-for-ri="2018875" type="text/json">{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=38521413]'), work: {"id":38521413,"title":"Send Orders for Reprints to reprints@benthamscience.ae Letters in Organic Novel Pyrazolyl Benzoxazole Conjugates: Design, Synthesis, Molecular Docking Studies and in vitro Anticancer Activities","created_at":"2019-03-09T18:49:49.887-08:00","url":"https://www.academia.edu/38521413/Send_Orders_for_Reprints_to_reprints_at_benthamscience_ae_Letters_in_Organic_Novel_Pyrazolyl_Benzoxazole_Conjugates_Design_Synthesis_Molecular_Docking_Studies_and_in_vitro_Anticancer_Activities?f_ri=2018875","dom_id":"work_38521413","summary":"Background: Nowadays, hybrid drugs have gained a significant role in the treatment of different health problems. Most of the hybrid molecules with different heterocyclic moieties were proved to be potent anti-tumor agents in cancer chemotherapy. Hence, the present study is aimed at the evaluation of in vitro anticancer activity of novel hybrid molecules (pyrazolyl benzoxazole conjugates) and to investigate their anticancer activity by molecular docking studies. Methods: Designed, synthesized and characterized the novel pyrazolyl benzoxazole conjugates. Anticancer activity of these compounds was determined by SRB assay. Then molecular docking studies were carried out against proto-oncogene tyrosine-protein kinase (ATP-Src, PDB: 2BDF), a putative target for cancer. Results: All the synthesized compound derivatives were evaluated against MCF-7, KB, Hop62 and A549 cancer cell lines. Compounds 9b and 9c exhibited excellent anticancer activities with GI 50 values of \u003c0.1 µM against MCF-7 and A549 cell lines. Compound 9e exhibited good antitumor activity on MCF-7 and A-549 with GI 50 values of 0.12 µM and 0.19 µM respectively. Compound 9g showed better anticancer activity on A-549 cancer cell line with GI 50 value of 0.34 µM. Conclusion: The two-hybrid molecules 9b and 9c are found to be comparably potent with the standard drug doxorubicin and may act as drug lead compounds in medicinal chemistry aspect. The present docking investigation proved that having benzoxazole of compound 9c at benzofuran of reference compound N-acetyl pyrazoline derivative might be valid for contributing to anti-cancer activity.","downloadable_attachments":[{"id":58590183,"asset_id":38521413,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":14607322,"first_name":"Ratnakaram","last_name":"Venkata Nadh","domain_name":"gitam","page_name":"RatnakaramVenkataNadh","display_name":"Ratnakaram Venkata Nadh","profile_url":"https://gitam.academia.edu/RatnakaramVenkataNadh?f_ri=2018875","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":314240,"name":"Doxorubicin","url":"https://www.academia.edu/Documents/in/Doxorubicin?f_ri=2018875","nofollow":true},{"id":824508,"name":"Benzoxazoles","url":"https://www.academia.edu/Documents/in/Benzoxazoles?f_ri=2018875","nofollow":true},{"id":956327,"name":"Pyrazole","url":"https://www.academia.edu/Documents/in/Pyrazole?f_ri=2018875","nofollow":true},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true},{"id":3157438,"name":"Molecular docking studies","url":"https://www.academia.edu/Documents/in/Molecular_docking_studies?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_74513841" data-work_id="74513841" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/74513841/Quick_Response_Code">Quick Response Code</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized"><a href="http://www.ijpsr.com" rel="nofollow">www.ijpsr.com</a> Cancer is the second leading cause of death worldwide. In USA three persons out of five will develop some type of cancer. Beyond these statistics of mortality, the morbidity due to cancer presents a real scary picture. Last... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_74513841" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden"><a href="http://www.ijpsr.com" rel="nofollow">www.ijpsr.com</a> Cancer is the second leading cause of death worldwide. In USA three persons out of five will develop some type of cancer. Beyond these statistics of mortality, the morbidity due to cancer presents a real scary picture. Last 50 years of research has rendered some types of cancer curable, but still the major fear factor associated with this disease is unchanged. Animal models are classified according to the method of induction of cancer in the animal. Spontaneous tumor models are the most primitive models. Although these models show good resemblance to the natural disease in humans, they were not capable of keeping pace with developing experimental therapeutics programs. It has therefore been necessary to take a further step towards artificiality, away from the clinical problem in the search for satisfactory testing method. From this step, the journey of artificially induced tumor models started. It is possible to induce cancer reproducibly in animals by</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/74513841" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ff588918232cf4078df434b396c1b428" rel="nofollow" data-download="{"attachment_id":82639576,"asset_id":74513841,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/82639576/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="50494803" href="https://paruluniversity.academia.edu/ArchanaNAvale">Archana NAvale</a><script data-card-contents-for-user="50494803" type="text/json">{"id":50494803,"first_name":"Archana","last_name":"NAvale","domain_name":"paruluniversity","page_name":"ArchanaNAvale","display_name":"Archana NAvale","profile_url":"https://paruluniversity.academia.edu/ArchanaNAvale?f_ri=2018875","photo":"https://0.academia-photos.com/50494803/122879756/112223847/s65_archana.navale.jpeg"}</script></span></span></li><li class="js-paper-rank-work_74513841 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="74513841"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 74513841, container: ".js-paper-rank-work_74513841", }); 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$(".js-view-count[data-work-id=74513841]").text(description); $(".js-view-count-work_74513841").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_74513841").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="74513841"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="11257" rel="nofollow" href="https://www.academia.edu/Documents/in/Drug_delivery">Drug delivery</a>, <script data-card-contents-for-ri="11257" type="text/json">{"id":11257,"name":"Drug delivery","url":"https://www.academia.edu/Documents/in/Drug_delivery?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="75847" rel="nofollow" href="https://www.academia.edu/Documents/in/HPLC">HPLC</a>, <script data-card-contents-for-ri="75847" type="text/json">{"id":75847,"name":"HPLC","url":"https://www.academia.edu/Documents/in/HPLC?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="83315" rel="nofollow" href="https://www.academia.edu/Documents/in/Diffusion">Diffusion</a>, <script data-card-contents-for-ri="83315" type="text/json">{"id":83315,"name":"Diffusion","url":"https://www.academia.edu/Documents/in/Diffusion?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="116078" rel="nofollow" href="https://www.academia.edu/Documents/in/Staphylococcus_aureus">Staphylococcus aureus</a><script data-card-contents-for-ri="116078" type="text/json">{"id":116078,"name":"Staphylococcus aureus","url":"https://www.academia.edu/Documents/in/Staphylococcus_aureus?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=74513841]'), work: {"id":74513841,"title":"Quick Response Code","created_at":"2022-03-24T23:12:54.326-07:00","url":"https://www.academia.edu/74513841/Quick_Response_Code?f_ri=2018875","dom_id":"work_74513841","summary":"www.ijpsr.com Cancer is the second leading cause of death worldwide. In USA three persons out of five will develop some type of cancer. Beyond these statistics of mortality, the morbidity due to cancer presents a real scary picture. Last 50 years of research has rendered some types of cancer curable, but still the major fear factor associated with this disease is unchanged. Animal models are classified according to the method of induction of cancer in the animal. Spontaneous tumor models are the most primitive models. Although these models show good resemblance to the natural disease in humans, they were not capable of keeping pace with developing experimental therapeutics programs. It has therefore been necessary to take a further step towards artificiality, away from the clinical problem in the search for satisfactory testing method. From this step, the journey of artificially induced tumor models started. It is possible to induce cancer reproducibly in animals by","downloadable_attachments":[{"id":82639576,"asset_id":74513841,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":50494803,"first_name":"Archana","last_name":"NAvale","domain_name":"paruluniversity","page_name":"ArchanaNAvale","display_name":"Archana NAvale","profile_url":"https://paruluniversity.academia.edu/ArchanaNAvale?f_ri=2018875","photo":"https://0.academia-photos.com/50494803/122879756/112223847/s65_archana.navale.jpeg"}],"research_interests":[{"id":11257,"name":"Drug delivery","url":"https://www.academia.edu/Documents/in/Drug_delivery?f_ri=2018875","nofollow":true},{"id":75847,"name":"HPLC","url":"https://www.academia.edu/Documents/in/HPLC?f_ri=2018875","nofollow":true},{"id":83315,"name":"Diffusion","url":"https://www.academia.edu/Documents/in/Diffusion?f_ri=2018875","nofollow":true},{"id":116078,"name":"Staphylococcus aureus","url":"https://www.academia.edu/Documents/in/Staphylococcus_aureus?f_ri=2018875","nofollow":true},{"id":231584,"name":"Staphylococcus epidermidis","url":"https://www.academia.edu/Documents/in/Staphylococcus_epidermidis?f_ri=2018875"},{"id":302037,"name":"In Vivo","url":"https://www.academia.edu/Documents/in/In_Vivo?f_ri=2018875"},{"id":432613,"name":"Animal models","url":"https://www.academia.edu/Documents/in/Animal_models?f_ri=2018875"},{"id":615457,"name":"Analytical Methods","url":"https://www.academia.edu/Documents/in/Analytical_Methods?f_ri=2018875"},{"id":782913,"name":"Ciprofloxacin","url":"https://www.academia.edu/Documents/in/Ciprofloxacin?f_ri=2018875"},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"},{"id":3460364,"name":"Neisseria meningitidis","url":"https://www.academia.edu/Documents/in/Neisseria_meningitidis?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_50739431" data-work_id="50739431" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/50739431/Anti_breast_cancer_potential_activity_of_Phaleria_macrocarpa_Scheff_Boerl_leaf_extract_through_in_silico_studies">Anti-breast cancer potential activity of Phaleria macrocarpa (Scheff.) Boerl. leaf extract through in silico studies</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Context: The development of apoptotic agent from natural plant products may have a beneficial effect as a promising candidate for cancer therapy. The study about the efficacy of Phaleria macrocarpa leaves on breast cancer is still... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_50739431" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Context: The development of apoptotic agent from natural plant products may have a beneficial effect as a promising candidate for cancer therapy. The study about the efficacy of Phaleria macrocarpa leaves on breast cancer is still limited.<br /><br />Aims: To elucidate the molecular mechanisms underlying the anti-breast cancer activity of P. macrocarpa leaves extract by in silico analysis.<br /><br />Methods: The compounds of the ethanol extract of P. macrocarpa were identified by Liquid Chromatography–High Resolution Mass Spectrometry (LC-HRMS) analysis. Fourteen bioactive compounds of P. macrocarpa leaf were analyzed to determine the biological activity using Prediction of Activity Spectra for Substances (PASS) server. The network analysis was analyzed using STRING (<a href="https://string-db.org/" rel="nofollow">https://string-db.org/</a>). Twelve selected compounds were docked with several protein targets, including caspase 3, Bax and Bcl-2. Molecular docking was done by Pyrx 0.8 software and visualized by Discovery Studio software. The pharmacological properties of investigated bioactive compounds were analyzed using the SwissADME web server.<br /><br />Results: The twelve from fourteen bioactive compounds of P. macrocarpa leaf have anticancer properties and might be expected to involve in p53 and PI3K/Akt signaling pathways related to cancer. The molecular docking result showed that sesamin from the lignans group has the best binding affinity to caspase-3 and Bax. Meanwhile, corymboside from the flavonoid group has the best binding affinity to Bcl-2.<br /><br />Conclusions: The bioactive compounds of P. macrocarpa leaves extract might potentially modulate apoptosis and cell growth. Further research should be performed to validate the activity of P. macrocarpa bioactive compounds for target cancer development.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/50739431" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e3a8e8ac595567bd563aa4c1f4f9832c" rel="nofollow" data-download="{"attachment_id":68610952,"asset_id":50739431,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/68610952/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="13838875" href="https://independent.academia.edu/JournalPharmacyPharmacognosyResJPPRes">Journal Pharmacy Pharmacognosy Res JPPRes</a><script data-card-contents-for-user="13838875" type="text/json">{"id":13838875,"first_name":"Journal Pharmacy Pharmacognosy Res","last_name":"JPPRes","domain_name":"independent","page_name":"JournalPharmacyPharmacognosyResJPPRes","display_name":"Journal Pharmacy Pharmacognosy Res JPPRes","profile_url":"https://independent.academia.edu/JournalPharmacyPharmacognosyResJPPRes?f_ri=2018875","photo":"https://gravatar.com/avatar/73db849da28752992bc1b6c420c97630?s=65"}</script></span></span></li><li class="js-paper-rank-work_50739431 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="50739431"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 50739431, container: ".js-paper-rank-work_50739431", }); 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$(".js-view-count[data-work-id=50739431]").text(description); $(".js-view-count-work_50739431").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_50739431").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="50739431"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4086" rel="nofollow" href="https://www.academia.edu/Documents/in/Traditional_Medicine">Traditional Medicine</a>, <script data-card-contents-for-ri="4086" type="text/json">{"id":4086,"name":"Traditional Medicine","url":"https://www.academia.edu/Documents/in/Traditional_Medicine?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="15019" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicinal_Plants">Medicinal Plants</a>, <script data-card-contents-for-ri="15019" type="text/json">{"id":15019,"name":"Medicinal Plants","url":"https://www.academia.edu/Documents/in/Medicinal_Plants?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="44297" rel="nofollow" href="https://www.academia.edu/Documents/in/Herbal_Medicine">Herbal Medicine</a>, <script data-card-contents-for-ri="44297" type="text/json">{"id":44297,"name":"Herbal Medicine","url":"https://www.academia.edu/Documents/in/Herbal_Medicine?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="141145" rel="nofollow" href="https://www.academia.edu/Documents/in/Plantas_Medicinales">Plantas Medicinales</a><script data-card-contents-for-ri="141145" type="text/json">{"id":141145,"name":"Plantas Medicinales","url":"https://www.academia.edu/Documents/in/Plantas_Medicinales?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=50739431]'), work: {"id":50739431,"title":"Anti-breast cancer potential activity of Phaleria macrocarpa (Scheff.) Boerl. leaf extract through in silico studies","created_at":"2021-08-04T20:28:04.824-07:00","url":"https://www.academia.edu/50739431/Anti_breast_cancer_potential_activity_of_Phaleria_macrocarpa_Scheff_Boerl_leaf_extract_through_in_silico_studies?f_ri=2018875","dom_id":"work_50739431","summary":"Context: The development of apoptotic agent from natural plant products may have a beneficial effect as a promising candidate for cancer therapy. The study about the efficacy of Phaleria macrocarpa leaves on breast cancer is still limited.\n\nAims: To elucidate the molecular mechanisms underlying the anti-breast cancer activity of P. macrocarpa leaves extract by in silico analysis.\n\nMethods: The compounds of the ethanol extract of P. macrocarpa were identified by Liquid Chromatography–High Resolution Mass Spectrometry (LC-HRMS) analysis. Fourteen bioactive compounds of P. macrocarpa leaf were analyzed to determine the biological activity using Prediction of Activity Spectra for Substances (PASS) server. The network analysis was analyzed using STRING (https://string-db.org/). Twelve selected compounds were docked with several protein targets, including caspase 3, Bax and Bcl-2. Molecular docking was done by Pyrx 0.8 software and visualized by Discovery Studio software. The pharmacological properties of investigated bioactive compounds were analyzed using the SwissADME web server.\n\nResults: The twelve from fourteen bioactive compounds of P. macrocarpa leaf have anticancer properties and might be expected to involve in p53 and PI3K/Akt signaling pathways related to cancer. The molecular docking result showed that sesamin from the lignans group has the best binding affinity to caspase-3 and Bax. Meanwhile, corymboside from the flavonoid group has the best binding affinity to Bcl-2.\n\nConclusions: The bioactive compounds of P. macrocarpa leaves extract might potentially modulate apoptosis and cell growth. Further research should be performed to validate the activity of P. macrocarpa bioactive compounds for target cancer development.","downloadable_attachments":[{"id":68610952,"asset_id":50739431,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":13838875,"first_name":"Journal Pharmacy Pharmacognosy Res","last_name":"JPPRes","domain_name":"independent","page_name":"JournalPharmacyPharmacognosyResJPPRes","display_name":"Journal Pharmacy Pharmacognosy Res JPPRes","profile_url":"https://independent.academia.edu/JournalPharmacyPharmacognosyResJPPRes?f_ri=2018875","photo":"https://gravatar.com/avatar/73db849da28752992bc1b6c420c97630?s=65"}],"research_interests":[{"id":4086,"name":"Traditional Medicine","url":"https://www.academia.edu/Documents/in/Traditional_Medicine?f_ri=2018875","nofollow":true},{"id":15019,"name":"Medicinal Plants","url":"https://www.academia.edu/Documents/in/Medicinal_Plants?f_ri=2018875","nofollow":true},{"id":44297,"name":"Herbal Medicine","url":"https://www.academia.edu/Documents/in/Herbal_Medicine?f_ri=2018875","nofollow":true},{"id":141145,"name":"Plantas Medicinales","url":"https://www.academia.edu/Documents/in/Plantas_Medicinales?f_ri=2018875","nofollow":true},{"id":141235,"name":"Molecular docking","url":"https://www.academia.edu/Documents/in/Molecular_docking?f_ri=2018875"},{"id":373895,"name":"medicinal \u0026 Aromatic plants","url":"https://www.academia.edu/Documents/in/medicinal_and_Aromatic_plants?f_ri=2018875"},{"id":679387,"name":"Bioactive Compound Isolation","url":"https://www.academia.edu/Documents/in/Bioactive_Compound_Isolation?f_ri=2018875"},{"id":700808,"name":"Bioactive Compounds","url":"https://www.academia.edu/Documents/in/Bioactive_Compounds?f_ri=2018875"},{"id":1005523,"name":"Bioactive Compound","url":"https://www.academia.edu/Documents/in/Bioactive_Compound?f_ri=2018875"},{"id":1134083,"name":"Medicinal Plant","url":"https://www.academia.edu/Documents/in/Medicinal_Plant?f_ri=2018875"},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"},{"id":2225815,"name":"Binding affinity","url":"https://www.academia.edu/Documents/in/Binding_affinity?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_50377593" data-work_id="50377593" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/50377593/Synthesis_and_Characterization_of_Novel_N_Benzylbenzimidazole_Linked_Pyrimidine_Derivatives_as_Anticancer_Agents">Synthesis and Characterization of Novel N-Benzylbenzimidazole Linked Pyrimidine Derivatives as Anticancer Agents</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Emergence of resistance to accessible anticancer drugs became a threat to human lives in the recent time. To address this issue, discovery of novel anticancer agents becomes very essential. Benzimidazoles and pyrimidines have... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_50377593" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Emergence of resistance to accessible anticancer drugs became a threat to human lives in the recent time. To address this issue, discovery of novel anticancer agents becomes very essential. Benzimidazoles and pyrimidines have been reported to possess potent anticancer activity. Materials and Methods: A hybrid approach has been used, in which core structure of potentially active N-benzyl benzimidazole and pyrimidine derivatives are brought together in to a single molecule. The desired compounds were prepared by the condensation of N-benzyl benzimidazole chalcones with guanidine hydrochloride. The synthesized compounds were characterized using spectral studies (IR, 1 H, 13 C-NMR techniques and mass spectrometry). All the compounds were screened for their anticancer activity against human breast cancer cell line MDA-MB-231. Results: The spectral data's are in well agreement with the synthesized compounds 5a-e. Compounds 5b (GI 50 = 39.6 μM) and 5a (GI 50 =84.0 μM) exhibited significant anticancer activity. Conclusion: Owing to the anticancer activity, compound 5b can be used as lead structure in the development of yet more potent anticancer agents.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/50377593" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5f882729544099d517ea9640c7e3d9de" rel="nofollow" data-download="{"attachment_id":68390525,"asset_id":50377593,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/68390525/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="13713939" href="https://cutm.academia.edu/GopalKrishnaPadhy">Gopal Krishna Padhy</a><script data-card-contents-for-user="13713939" type="text/json">{"id":13713939,"first_name":"Gopal Krishna","last_name":"Padhy","domain_name":"cutm","page_name":"GopalKrishnaPadhy","display_name":"Gopal Krishna Padhy","profile_url":"https://cutm.academia.edu/GopalKrishnaPadhy?f_ri=2018875","photo":"https://0.academia-photos.com/13713939/3815633/34787312/s65_gopal_krishna.padhy.jpg"}</script></span></span></li><li class="js-paper-rank-work_50377593 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="50377593"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 50377593, container: ".js-paper-rank-work_50377593", }); });</script></li><li class="js-percentile-work_50377593 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 50377593; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_50377593"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_50377593 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="50377593"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 50377593; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=50377593]").text(description); $(".js-view-count-work_50377593").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_50377593").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="50377593"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="425464" rel="nofollow" href="https://www.academia.edu/Documents/in/Pyrimidine">Pyrimidine</a>, <script data-card-contents-for-ri="425464" type="text/json">{"id":425464,"name":"Pyrimidine","url":"https://www.academia.edu/Documents/in/Pyrimidine?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="1003055" rel="nofollow" href="https://www.academia.edu/Documents/in/Anticancer_Agents">Anticancer Agents</a>, <script data-card-contents-for-ri="1003055" type="text/json">{"id":1003055,"name":"Anticancer Agents","url":"https://www.academia.edu/Documents/in/Anticancer_Agents?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2018875" rel="nofollow" href="https://www.academia.edu/Documents/in/Anticancer_activity">Anticancer activity</a>, <script data-card-contents-for-ri="2018875" type="text/json">{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3789884" rel="nofollow" href="https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences">Pharmacology and pharmaceutical sciences</a><script data-card-contents-for-ri="3789884" type="text/json">{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=50377593]'), work: {"id":50377593,"title":"Synthesis and Characterization of Novel N-Benzylbenzimidazole Linked Pyrimidine Derivatives as Anticancer Agents","created_at":"2021-07-30T04:10:49.673-07:00","url":"https://www.academia.edu/50377593/Synthesis_and_Characterization_of_Novel_N_Benzylbenzimidazole_Linked_Pyrimidine_Derivatives_as_Anticancer_Agents?f_ri=2018875","dom_id":"work_50377593","summary":"Background: Emergence of resistance to accessible anticancer drugs became a threat to human lives in the recent time. To address this issue, discovery of novel anticancer agents becomes very essential. Benzimidazoles and pyrimidines have been reported to possess potent anticancer activity. Materials and Methods: A hybrid approach has been used, in which core structure of potentially active N-benzyl benzimidazole and pyrimidine derivatives are brought together in to a single molecule. The desired compounds were prepared by the condensation of N-benzyl benzimidazole chalcones with guanidine hydrochloride. The synthesized compounds were characterized using spectral studies (IR, 1 H, 13 C-NMR techniques and mass spectrometry). All the compounds were screened for their anticancer activity against human breast cancer cell line MDA-MB-231. Results: The spectral data's are in well agreement with the synthesized compounds 5a-e. Compounds 5b (GI 50 = 39.6 μM) and 5a (GI 50 =84.0 μM) exhibited significant anticancer activity. Conclusion: Owing to the anticancer activity, compound 5b can be used as lead structure in the development of yet more potent anticancer agents.","downloadable_attachments":[{"id":68390525,"asset_id":50377593,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":13713939,"first_name":"Gopal Krishna","last_name":"Padhy","domain_name":"cutm","page_name":"GopalKrishnaPadhy","display_name":"Gopal Krishna Padhy","profile_url":"https://cutm.academia.edu/GopalKrishnaPadhy?f_ri=2018875","photo":"https://0.academia-photos.com/13713939/3815633/34787312/s65_gopal_krishna.padhy.jpg"}],"research_interests":[{"id":425464,"name":"Pyrimidine","url":"https://www.academia.edu/Documents/in/Pyrimidine?f_ri=2018875","nofollow":true},{"id":1003055,"name":"Anticancer Agents","url":"https://www.academia.edu/Documents/in/Anticancer_Agents?f_ri=2018875","nofollow":true},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences?f_ri=2018875","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_47691438" data-work_id="47691438" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/47691438/Evaluation_of_the_Phytochemical_Antioxidant_Antibacterial_and_Anticancer_Activity_of_Prunus_domestica_Fruit">Evaluation of the Phytochemical, Antioxidant, Antibacterial and Anticancer Activity of Prunus domestica Fruit</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Plants have been used long ago through man history of life for their use in food and medicinal drives. In modern life, natural products have been extracted and isolated from several kinds of plants for the development of new drugs. There... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_47691438" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Plants have been used long ago through man history of life for their use in food and medicinal drives. In modern life, natural products have been extracted and isolated from several kinds of plants for the development of new drugs. There are numerous interests in natural antioxidants extracted from medicinal plants, vegetables and fruits, which might help to prevent oxidative damage. One of such plants is plum Prunus domestica L., family Rosaceae. Samples from ‘African Rose’, and ‘Santa Rosa’ plum cultivars were collected from local market in Giza governorate, Egypt. The main phytochemicals of plums (fruit flesh and skin) were analyzed. Total polyphenols, flavonoids, tannins, anthocyanins, and reducing power were higher in ‘African Rose’ fruit. The ethanolic and ethyl acetate extracts of two plum cultivars were both high in the antioxidant effect with IC50 13.923 and 18.416 μg/ml of ethanolic extract of ‘African Rose’, and ‘Santa Rosa’ respectively. The IC50 of ‘African Rose’ and ‘S...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/47691438" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="28fb965b46bb4946d7079ae376cf5ee3" rel="nofollow" data-download="{"attachment_id":66653253,"asset_id":47691438,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/66653253/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="186890010" href="https://independent.academia.edu/MaiMostafa51">Mai Mostafa</a><script data-card-contents-for-user="186890010" type="text/json">{"id":186890010,"first_name":"Mai","last_name":"Mostafa","domain_name":"independent","page_name":"MaiMostafa51","display_name":"Mai Mostafa","profile_url":"https://independent.academia.edu/MaiMostafa51?f_ri=2018875","photo":"https://0.academia-photos.com/186890010/51744197/39830115/s65_mai.mostafa.jpeg"}</script></span></span></li><li class="js-paper-rank-work_47691438 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="47691438"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 47691438, container: ".js-paper-rank-work_47691438", }); });</script></li><li class="js-percentile-work_47691438 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47691438; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_47691438"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_47691438 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="47691438"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47691438; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47691438]").text(description); $(".js-view-count-work_47691438").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_47691438").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="47691438"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="103339" rel="nofollow" href="https://www.academia.edu/Documents/in/Antioxidant">Antioxidant</a>, <script data-card-contents-for-ri="103339" type="text/json">{"id":103339,"name":"Antioxidant","url":"https://www.academia.edu/Documents/in/Antioxidant?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="347988" rel="nofollow" href="https://www.academia.edu/Documents/in/Phenols">Phenols</a>, <script data-card-contents-for-ri="347988" type="text/json">{"id":347988,"name":"Phenols","url":"https://www.academia.edu/Documents/in/Phenols?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="382472" rel="nofollow" href="https://www.academia.edu/Documents/in/DPPH">DPPH</a>, <script data-card-contents-for-ri="382472" type="text/json">{"id":382472,"name":"DPPH","url":"https://www.academia.edu/Documents/in/DPPH?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="913998" rel="nofollow" href="https://www.academia.edu/Documents/in/Antibacterial">Antibacterial</a><script data-card-contents-for-ri="913998" type="text/json">{"id":913998,"name":"Antibacterial","url":"https://www.academia.edu/Documents/in/Antibacterial?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=47691438]'), work: {"id":47691438,"title":"Evaluation of the Phytochemical, Antioxidant, Antibacterial and Anticancer Activity of Prunus domestica Fruit","created_at":"2021-04-23T21:22:46.274-07:00","url":"https://www.academia.edu/47691438/Evaluation_of_the_Phytochemical_Antioxidant_Antibacterial_and_Anticancer_Activity_of_Prunus_domestica_Fruit?f_ri=2018875","dom_id":"work_47691438","summary":"Plants have been used long ago through man history of life for their use in food and medicinal drives. In modern life, natural products have been extracted and isolated from several kinds of plants for the development of new drugs. There are numerous interests in natural antioxidants extracted from medicinal plants, vegetables and fruits, which might help to prevent oxidative damage. One of such plants is plum Prunus domestica L., family Rosaceae. Samples from ‘African Rose’, and ‘Santa Rosa’ plum cultivars were collected from local market in Giza governorate, Egypt. The main phytochemicals of plums (fruit flesh and skin) were analyzed. Total polyphenols, flavonoids, tannins, anthocyanins, and reducing power were higher in ‘African Rose’ fruit. The ethanolic and ethyl acetate extracts of two plum cultivars were both high in the antioxidant effect with IC50 13.923 and 18.416 μg/ml of ethanolic extract of ‘African Rose’, and ‘Santa Rosa’ respectively. The IC50 of ‘African Rose’ and ‘S...","downloadable_attachments":[{"id":66653253,"asset_id":47691438,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":186890010,"first_name":"Mai","last_name":"Mostafa","domain_name":"independent","page_name":"MaiMostafa51","display_name":"Mai Mostafa","profile_url":"https://independent.academia.edu/MaiMostafa51?f_ri=2018875","photo":"https://0.academia-photos.com/186890010/51744197/39830115/s65_mai.mostafa.jpeg"}],"research_interests":[{"id":103339,"name":"Antioxidant","url":"https://www.academia.edu/Documents/in/Antioxidant?f_ri=2018875","nofollow":true},{"id":347988,"name":"Phenols","url":"https://www.academia.edu/Documents/in/Phenols?f_ri=2018875","nofollow":true},{"id":382472,"name":"DPPH","url":"https://www.academia.edu/Documents/in/DPPH?f_ri=2018875","nofollow":true},{"id":913998,"name":"Antibacterial","url":"https://www.academia.edu/Documents/in/Antibacterial?f_ri=2018875","nofollow":true},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_45586030 coauthored" data-work_id="45586030" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/45586030/Anticancer_activity_of_milk_fat_rich_in_conjugated_linoleic_acid_against_Ehrlich_ascites_carcinoma_cells_in_female_Swiss_albino_mice">Anticancer activity of milk fat rich in conjugated linoleic acid against Ehrlich ascites carcinoma cells in female Swiss albino mice</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background and Aim: The major conjugated linoleic acid (CLA) isomers have anticancer effect, especially breast cancer cells, inhibits cell growth and induces cell death. Also, CLA has several health benefits in vivo, including... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_45586030" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background and Aim: The major conjugated linoleic acid (CLA) isomers have anticancer effect, especially breast cancer cells, inhibits cell growth and induces cell death. Also, CLA has several health benefits in vivo, including antiatherogenesis, antiobesity, and modulation of immune function. The present study aimed to assess the safety and anticancer effects of milk fat CLA against in vivo Ehrlich ascites carcinoma (EAC) in female Swiss albino mice. This was based on acute toxicity study, detection of the tumor growth, life span of EAC bearing hosts, and simultaneous alterations in the hematological, biochemical, and histopathological profiles.<br /><br />Materials and Methods: One hundred and fifty adult female mice were equally divided into five groups. Groups (1-2) were normal controls, and Groups (3-5) were tumor transplanted mice (TTM) inoculated intraperitoneally with EAC cells (2×106/0.2 mL). Group (3) was (TTM positive control). Group (4) TTM fed orally on balanced diet supplemented with milk fat CLA (40 mg CLA/kg body weight). Group (5) TTM fed orally on balanced diet supplemented with the same level of CLA 28 days before tumor cells inoculation. Blood samples and specimens from liver and kidney were collected from each group. The effect of milk fat CLA on the growth of tumor, life span of TTM, and simultaneous alterations in the hematological, biochemical, and histopathological profiles were examined.<br /><br />Results: For CLA treated TTM, significant decrease in tumor weight, ascetic volume, viable Ehrlich cells accompanied with increase in life span were observed. Hematological and biochemical profiles reverted to more or less normal levels and histopathology showed minimal effects.<br /><br />Conclusion: The present study proved the safety and anticancer efficiency of milk fat CLA and provides a scientific basis for its medicinal use as anticancer attributable to the additive or synergistic effects of its isomers.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/45586030" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ba738b55584dd896a89222ee61038640" rel="nofollow" data-download="{"attachment_id":66064720,"asset_id":45586030,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/66064720/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="61334658" href="https://independent.academia.edu/VeterinaryWorld">Veterinary World</a><script data-card-contents-for-user="61334658" type="text/json">{"id":61334658,"first_name":"Veterinary","last_name":"World","domain_name":"independent","page_name":"VeterinaryWorld","display_name":"Veterinary World","profile_url":"https://independent.academia.edu/VeterinaryWorld?f_ri=2018875","photo":"https://0.academia-photos.com/61334658/15944941/16446323/s65_veterinary.world.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-45586030">+1</span><div class="hidden js-additional-users-45586030"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/ProfShereinSaied">Prof./ Sherein Saied</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-45586030'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-45586030').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_45586030 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="45586030"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 45586030, container: ".js-paper-rank-work_45586030", }); });</script></li><li class="js-percentile-work_45586030 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 45586030; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_45586030"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_45586030 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="45586030"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45586030; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=45586030]").text(description); $(".js-view-count-work_45586030").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_45586030").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="45586030"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="626" rel="nofollow" href="https://www.academia.edu/Documents/in/Oncology">Oncology</a>, <script data-card-contents-for-ri="626" type="text/json">{"id":626,"name":"Oncology","url":"https://www.academia.edu/Documents/in/Oncology?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6021" rel="nofollow" href="https://www.academia.edu/Documents/in/Cancer">Cancer</a>, <script data-card-contents-for-ri="6021" type="text/json">{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="24355" rel="nofollow" href="https://www.academia.edu/Documents/in/Carcinology">Carcinology</a>, <script data-card-contents-for-ri="24355" type="text/json">{"id":24355,"name":"Carcinology","url":"https://www.academia.edu/Documents/in/Carcinology?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="371491" rel="nofollow" href="https://www.academia.edu/Documents/in/Carcinoma">Carcinoma</a><script data-card-contents-for-ri="371491" type="text/json">{"id":371491,"name":"Carcinoma","url":"https://www.academia.edu/Documents/in/Carcinoma?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=45586030]'), work: {"id":45586030,"title":"Anticancer activity of milk fat rich in conjugated linoleic acid against Ehrlich ascites carcinoma cells in female Swiss albino mice","created_at":"2021-03-20T06:06:22.882-07:00","url":"https://www.academia.edu/45586030/Anticancer_activity_of_milk_fat_rich_in_conjugated_linoleic_acid_against_Ehrlich_ascites_carcinoma_cells_in_female_Swiss_albino_mice?f_ri=2018875","dom_id":"work_45586030","summary":"Background and Aim: The major conjugated linoleic acid (CLA) isomers have anticancer effect, especially breast cancer cells, inhibits cell growth and induces cell death. Also, CLA has several health benefits in vivo, including antiatherogenesis, antiobesity, and modulation of immune function. The present study aimed to assess the safety and anticancer effects of milk fat CLA against in vivo Ehrlich ascites carcinoma (EAC) in female Swiss albino mice. This was based on acute toxicity study, detection of the tumor growth, life span of EAC bearing hosts, and simultaneous alterations in the hematological, biochemical, and histopathological profiles.\n\nMaterials and Methods: One hundred and fifty adult female mice were equally divided into five groups. Groups (1-2) were normal controls, and Groups (3-5) were tumor transplanted mice (TTM) inoculated intraperitoneally with EAC cells (2×106/0.2 mL). Group (3) was (TTM positive control). Group (4) TTM fed orally on balanced diet supplemented with milk fat CLA (40 mg CLA/kg body weight). Group (5) TTM fed orally on balanced diet supplemented with the same level of CLA 28 days before tumor cells inoculation. Blood samples and specimens from liver and kidney were collected from each group. The effect of milk fat CLA on the growth of tumor, life span of TTM, and simultaneous alterations in the hematological, biochemical, and histopathological profiles were examined.\n\nResults: For CLA treated TTM, significant decrease in tumor weight, ascetic volume, viable Ehrlich cells accompanied with increase in life span were observed. Hematological and biochemical profiles reverted to more or less normal levels and histopathology showed minimal effects.\n\nConclusion: The present study proved the safety and anticancer efficiency of milk fat CLA and provides a scientific basis for its medicinal use as anticancer attributable to the additive or synergistic effects of its isomers.","downloadable_attachments":[{"id":66064720,"asset_id":45586030,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":61334658,"first_name":"Veterinary","last_name":"World","domain_name":"independent","page_name":"VeterinaryWorld","display_name":"Veterinary World","profile_url":"https://independent.academia.edu/VeterinaryWorld?f_ri=2018875","photo":"https://0.academia-photos.com/61334658/15944941/16446323/s65_veterinary.world.jpg"},{"id":58874009,"first_name":"Prof./ Sherein","last_name":"Saied","domain_name":"independent","page_name":"ProfShereinSaied","display_name":"Prof./ Sherein Saied","profile_url":"https://independent.academia.edu/ProfShereinSaied?f_ri=2018875","photo":"https://gravatar.com/avatar/25b57b6e84c670d037a71c66e8584b31?s=65"}],"research_interests":[{"id":626,"name":"Oncology","url":"https://www.academia.edu/Documents/in/Oncology?f_ri=2018875","nofollow":true},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=2018875","nofollow":true},{"id":24355,"name":"Carcinology","url":"https://www.academia.edu/Documents/in/Carcinology?f_ri=2018875","nofollow":true},{"id":371491,"name":"Carcinoma","url":"https://www.academia.edu/Documents/in/Carcinoma?f_ri=2018875","nofollow":true},{"id":1683059,"name":"Conjugated linoleic acid","url":"https://www.academia.edu/Documents/in/Conjugated_linoleic_acid?f_ri=2018875"},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"},{"id":2754237,"name":"Ehrlich Ascites Carcinoma","url":"https://www.academia.edu/Documents/in/Ehrlich_Ascites_Carcinoma?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14503111" data-work_id="14503111" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14503111/Effect_of_a_Biofield_Treatment_on_Plant_Growth_and_Adaptation">Effect of a Biofield Treatment on Plant Growth and Adaptation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Quantum mechanics was developed when human energies of consciousness were found to influence observations at the scale of elementary particles, here referred as non-contact biofield treat-ment or biofield energies. Quantum mechanics has... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14503111" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Quantum mechanics was developed when human energies of consciousness were found to influence observations at the scale of elementary particles, here referred as non-contact biofield treat-ment or biofield energies. Quantum mechanics has also proved ef-ficacious in biological processes. The present experiments found an enhanced and significant impact of the biofield treatment on adaptive micropropagation response and callus induction of two plant spe-cies, Withania somnifera and Amaranthus dubius. The enhancement was perhaps due to greater focus on adaptation rather than specific mechanisms, showing high potential including at biochemical and genetic levels. Possible reasons for the enhancement are discussed and a possible model is presented, consistent with current scientific theory.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14503111" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9444e8f00d17ce21179117ebc5147dc4" rel="nofollow" data-download="{"attachment_id":38332396,"asset_id":14503111,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/38332396/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="6771312" href="https://independent.academia.edu/MahendraKumarTrivedi">Mahendra Kumar Trivedi</a><script data-card-contents-for-user="6771312" type="text/json">{"id":6771312,"first_name":"Mahendra Kumar","last_name":"Trivedi","domain_name":"independent","page_name":"MahendraKumarTrivedi","display_name":"Mahendra Kumar Trivedi","profile_url":"https://independent.academia.edu/MahendraKumarTrivedi?f_ri=2018875","photo":"https://0.academia-photos.com/6771312/9887017/117966475/s65_mahendra_kumar.trivedi.jpg"}</script></span></span></li><li class="js-paper-rank-work_14503111 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14503111"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14503111, container: ".js-paper-rank-work_14503111", }); 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$(".js-view-count[data-work-id=14503111]").text(description); $(".js-view-count-work_14503111").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14503111").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14503111"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="18433" rel="nofollow" href="https://www.academia.edu/Documents/in/Micropropagation">Micropropagation</a>, <script data-card-contents-for-ri="18433" type="text/json">{"id":18433,"name":"Micropropagation","url":"https://www.academia.edu/Documents/in/Micropropagation?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="25789" rel="nofollow" href="https://www.academia.edu/Documents/in/Human_Consciousness">Human Consciousness</a>, <script data-card-contents-for-ri="25789" type="text/json">{"id":25789,"name":"Human Consciousness","url":"https://www.academia.edu/Documents/in/Human_Consciousness?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="85564" rel="nofollow" href="https://www.academia.edu/Documents/in/Chlorophyll">Chlorophyll</a>, <script data-card-contents-for-ri="85564" type="text/json">{"id":85564,"name":"Chlorophyll","url":"https://www.academia.edu/Documents/in/Chlorophyll?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="118450" rel="nofollow" href="https://www.academia.edu/Documents/in/Glutathione">Glutathione</a><script data-card-contents-for-ri="118450" type="text/json">{"id":118450,"name":"Glutathione","url":"https://www.academia.edu/Documents/in/Glutathione?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14503111]'), work: {"id":14503111,"title":"Effect of a Biofield Treatment on Plant Growth and Adaptation","created_at":"2015-07-30T00:14:33.436-07:00","url":"https://www.academia.edu/14503111/Effect_of_a_Biofield_Treatment_on_Plant_Growth_and_Adaptation?f_ri=2018875","dom_id":"work_14503111","summary":"Quantum mechanics was developed when human energies of consciousness were found to influence observations at the scale of elementary particles, here referred as non-contact biofield treat-ment or biofield energies. Quantum mechanics has also proved ef-ficacious in biological processes. The present experiments found an enhanced and significant impact of the biofield treatment on adaptive micropropagation response and callus induction of two plant spe-cies, Withania somnifera and Amaranthus dubius. The enhancement was perhaps due to greater focus on adaptation rather than specific mechanisms, showing high potential including at biochemical and genetic levels. Possible reasons for the enhancement are discussed and a possible model is presented, consistent with current scientific theory.\r\n","downloadable_attachments":[{"id":38332396,"asset_id":14503111,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":6771312,"first_name":"Mahendra Kumar","last_name":"Trivedi","domain_name":"independent","page_name":"MahendraKumarTrivedi","display_name":"Mahendra Kumar Trivedi","profile_url":"https://independent.academia.edu/MahendraKumarTrivedi?f_ri=2018875","photo":"https://0.academia-photos.com/6771312/9887017/117966475/s65_mahendra_kumar.trivedi.jpg"}],"research_interests":[{"id":18433,"name":"Micropropagation","url":"https://www.academia.edu/Documents/in/Micropropagation?f_ri=2018875","nofollow":true},{"id":25789,"name":"Human Consciousness","url":"https://www.academia.edu/Documents/in/Human_Consciousness?f_ri=2018875","nofollow":true},{"id":85564,"name":"Chlorophyll","url":"https://www.academia.edu/Documents/in/Chlorophyll?f_ri=2018875","nofollow":true},{"id":118450,"name":"Glutathione","url":"https://www.academia.edu/Documents/in/Glutathione?f_ri=2018875","nofollow":true},{"id":673146,"name":"Plant Growth Regulator","url":"https://www.academia.edu/Documents/in/Plant_Growth_Regulator?f_ri=2018875"},{"id":1637153,"name":"Plant Adaptation","url":"https://www.academia.edu/Documents/in/Plant_Adaptation?f_ri=2018875"},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"},{"id":2018890,"name":"Non-contact Biofield treatment","url":"https://www.academia.edu/Documents/in/Non-contact_Biofield_treatment?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_77251228" data-work_id="77251228" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/77251228/Synthesis_Molecular_Docking_and_Anticancer_Activity_of_Novel_1_3_Thiazolidin_4_Ones">Synthesis, Molecular Docking and Anticancer Activity of Novel 1,3-Thiazolidin-4-Ones</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Cancer is a major cause of death all over the globe. Controlling cell division byinhibition of mitosis is the most successful clinical strategy for cancer treatment. The developmentof novel anticancer agents is the most... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_77251228" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Cancer is a major cause of death all over the globe. Controlling cell division byinhibition of mitosis is the most successful clinical strategy for cancer treatment. The developmentof novel anticancer agents is the most important area in medicinal chemistry and drug discoveryresearch. Thiazolidine is the multifunctional nucleus which shows a number of pharmacologicalactivities like anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, antidiabetic,antihyperlipidemic and antiarthritic. Methods: In a present study series of 2-substituted-3-(1H-benzimidazole-2-yl)-thiazolidin-4-ones were designed, synthesized by the microwave-assisted system, and characterized bymelting point, IR, 1H NMR, and mass spectroscopy. All the newly synthesized compoundswere examined for their in vitro anticancer activity against breast cancer cell line MCF-7 bySulforhodamine B (SRB) assay. Results: The compounds AB-12 (GI50: 28.5 μg/ml) and AB-6 (GI50: 50.7 μg/ml) exhibitedsignifi...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/77251228" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1b5ffbbf75122fdf7a0321b772907786" rel="nofollow" data-download="{"attachment_id":84666653,"asset_id":77251228,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/84666653/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1062290" href="https://kedarunipune.academia.edu/JyotiWadekar">Jyoti Wadekar</a><script data-card-contents-for-user="1062290" type="text/json">{"id":1062290,"first_name":"Jyoti","last_name":"Wadekar","domain_name":"kedarunipune","page_name":"JyotiWadekar","display_name":"Jyoti Wadekar","profile_url":"https://kedarunipune.academia.edu/JyotiWadekar?f_ri=2018875","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_77251228 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="77251228"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 77251228, container: ".js-paper-rank-work_77251228", }); 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$(".js-view-count[data-work-id=77251228]").text(description); $(".js-view-count-work_77251228").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_77251228").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="77251228"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">6</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="2375" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicinal_Chemistry">Medicinal Chemistry</a>, <script data-card-contents-for-ri="2375" type="text/json">{"id":2375,"name":"Medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Medicinal_Chemistry?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="55388" rel="nofollow" href="https://www.academia.edu/Documents/in/Organic_Synthesis">Organic Synthesis</a>, <script data-card-contents-for-ri="55388" type="text/json">{"id":55388,"name":"Organic Synthesis","url":"https://www.academia.edu/Documents/in/Organic_Synthesis?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="89956" rel="nofollow" href="https://www.academia.edu/Documents/in/Pharmaceutical_Sciences">Pharmaceutical Sciences</a>, <script data-card-contents-for-ri="89956" type="text/json">{"id":89956,"name":"Pharmaceutical Sciences","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Sciences?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="141235" rel="nofollow" href="https://www.academia.edu/Documents/in/Molecular_docking">Molecular docking</a><script data-card-contents-for-ri="141235" type="text/json">{"id":141235,"name":"Molecular docking","url":"https://www.academia.edu/Documents/in/Molecular_docking?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=77251228]'), work: {"id":77251228,"title":"Synthesis, Molecular Docking and Anticancer Activity of Novel 1,3-Thiazolidin-4-Ones","created_at":"2022-04-22T01:29:01.765-07:00","url":"https://www.academia.edu/77251228/Synthesis_Molecular_Docking_and_Anticancer_Activity_of_Novel_1_3_Thiazolidin_4_Ones?f_ri=2018875","dom_id":"work_77251228","summary":"Background: Cancer is a major cause of death all over the globe. Controlling cell division byinhibition of mitosis is the most successful clinical strategy for cancer treatment. The developmentof novel anticancer agents is the most important area in medicinal chemistry and drug discoveryresearch. Thiazolidine is the multifunctional nucleus which shows a number of pharmacologicalactivities like anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, antidiabetic,antihyperlipidemic and antiarthritic. Methods: In a present study series of 2-substituted-3-(1H-benzimidazole-2-yl)-thiazolidin-4-ones were designed, synthesized by the microwave-assisted system, and characterized bymelting point, IR, 1H NMR, and mass spectroscopy. All the newly synthesized compoundswere examined for their in vitro anticancer activity against breast cancer cell line MCF-7 bySulforhodamine B (SRB) assay. Results: The compounds AB-12 (GI50: 28.5 μg/ml) and AB-6 (GI50: 50.7 μg/ml) exhibitedsignifi...","downloadable_attachments":[{"id":84666653,"asset_id":77251228,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":1062290,"first_name":"Jyoti","last_name":"Wadekar","domain_name":"kedarunipune","page_name":"JyotiWadekar","display_name":"Jyoti Wadekar","profile_url":"https://kedarunipune.academia.edu/JyotiWadekar?f_ri=2018875","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2375,"name":"Medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Medicinal_Chemistry?f_ri=2018875","nofollow":true},{"id":55388,"name":"Organic Synthesis","url":"https://www.academia.edu/Documents/in/Organic_Synthesis?f_ri=2018875","nofollow":true},{"id":89956,"name":"Pharmaceutical Sciences","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Sciences?f_ri=2018875","nofollow":true},{"id":141235,"name":"Molecular docking","url":"https://www.academia.edu/Documents/in/Molecular_docking?f_ri=2018875","nofollow":true},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"},{"id":3875325,"name":"Tabriz University of Medical Sciences","url":"https://www.academia.edu/Documents/in/Tabriz_University_of_Medical_Sciences?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_70014744" data-work_id="70014744" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/70014744/Anticancer_activity_of_milk_fat_rich_in_conjugated_linoleic_acid_against_Ehrlich_ascites_carcinoma_cells_in_female_Swiss_albino_mice">Anticancer activity of milk fat rich in conjugated linoleic acid against Ehrlich ascites carcinoma cells in female Swiss albino mice</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background and Aim: The major conjugated linoleic acid (CLA) isomers have anticancer effect, especially breast cancer cells, inhibits cell growth and induces cell death. Also, CLA has several health benefits in vivo, including... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_70014744" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background and Aim: The major conjugated linoleic acid (CLA) isomers have anticancer effect, especially breast cancer cells, inhibits cell growth and induces cell death. Also, CLA has several health benefits in vivo, including antiatherogenesis, antiobesity, and modulation of immune function. The present study aimed to assess the safety and anticancer effects of milk fat CLA against in vivo Ehrlich ascites carcinoma (EAC) in female Swiss albino mice. This was based on acute toxicity study, detection of the tumor growth, life span of EAC bearing hosts, and simultaneous alterations in the hematological, biochemical, and histopathological profiles. Materials and Methods: One hundred and fifty adult female mice were equally divided into five groups. Groups (1-2) were normal controls, and Groups (3-5) were tumor transplanted mice (TTM) inoculated intraperitoneally with EAC cells (2×106/0.2 mL). Group (3) was (TTM positive control). Group (4) TTM fed orally on balanced diet supplemented w...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/70014744" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="91706570c3ad1627a55735de6efdbb55" rel="nofollow" data-download="{"attachment_id":79902330,"asset_id":70014744,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/79902330/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="186650848" href="https://independent.academia.edu/RidaAli77">Rida Ali</a><script data-card-contents-for-user="186650848" type="text/json">{"id":186650848,"first_name":"Rida","last_name":"Ali","domain_name":"independent","page_name":"RidaAli77","display_name":"Rida Ali","profile_url":"https://independent.academia.edu/RidaAli77?f_ri=2018875","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_70014744 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="70014744"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 70014744, container: ".js-paper-rank-work_70014744", }); 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Also, CLA has several health benefits in vivo, including antiatherogenesis, antiobesity, and modulation of immune function. The present study aimed to assess the safety and anticancer effects of milk fat CLA against in vivo Ehrlich ascites carcinoma (EAC) in female Swiss albino mice. This was based on acute toxicity study, detection of the tumor growth, life span of EAC bearing hosts, and simultaneous alterations in the hematological, biochemical, and histopathological profiles. Materials and Methods: One hundred and fifty adult female mice were equally divided into five groups. Groups (1-2) were normal controls, and Groups (3-5) were tumor transplanted mice (TTM) inoculated intraperitoneally with EAC cells (2×106/0.2 mL). Group (3) was (TTM positive control). Group (4) TTM fed orally on balanced diet supplemented w...","downloadable_attachments":[{"id":79902330,"asset_id":70014744,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":186650848,"first_name":"Rida","last_name":"Ali","domain_name":"independent","page_name":"RidaAli77","display_name":"Rida Ali","profile_url":"https://independent.academia.edu/RidaAli77?f_ri=2018875","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":626,"name":"Oncology","url":"https://www.academia.edu/Documents/in/Oncology?f_ri=2018875","nofollow":true},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=2018875","nofollow":true},{"id":24355,"name":"Carcinology","url":"https://www.academia.edu/Documents/in/Carcinology?f_ri=2018875","nofollow":true},{"id":371491,"name":"Carcinoma","url":"https://www.academia.edu/Documents/in/Carcinoma?f_ri=2018875","nofollow":true},{"id":1117458,"name":"March","url":"https://www.academia.edu/Documents/in/March?f_ri=2018875"},{"id":1683059,"name":"Conjugated linoleic acid","url":"https://www.academia.edu/Documents/in/Conjugated_linoleic_acid?f_ri=2018875"},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"},{"id":2754237,"name":"Ehrlich Ascites Carcinoma","url":"https://www.academia.edu/Documents/in/Ehrlich_Ascites_Carcinoma?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_61311975" data-work_id="61311975" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/61311975/Anticancer_activity_of_milk_fat_rich_in_conjugated_linoleic_acid_against_Ehrlich_ascites_carcinoma_cells_in_female_Swiss_albino_mice">Anticancer activity of milk fat rich in conjugated linoleic acid against Ehrlich ascites carcinoma cells in female Swiss albino mice</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background and Aim: The major conjugated linoleic acid (CLA) isomers have anticancer effect, especially breast cancer cells, inhibits cell growth and induces cell death. Also, CLA has several health benefits in vivo, including... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_61311975" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background and Aim: The major conjugated linoleic acid (CLA) isomers have anticancer effect, especially breast cancer cells, inhibits cell growth and induces cell death. Also, CLA has several health benefits in vivo, including antiatherogenesis, antiobesity, and modulation of immune function. The present study aimed to assess the safety and anticancer effects of milk fat CLA against in vivo Ehrlich ascites carcinoma (EAC) in female Swiss albino mice. This was based on acute toxicity study, detection of the tumor growth, life span of EAC bearing hosts, and simultaneous alterations in the hematological, biochemical, and histopathological profiles. Materials and Methods: One hundred and fifty adult female mice were equally divided into five groups. Groups (1-2) were normal controls, and Groups (3-5) were tumor transplanted mice (TTM) inoculated intraperitoneally with EAC cells (2×106/0.2 mL). Group (3) was (TTM positive control). Group (4) TTM fed orally on balanced diet supplemented w...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/61311975" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2c4754f68efa865ebc9acd0b8ecf1a55" rel="nofollow" data-download="{"attachment_id":74377843,"asset_id":61311975,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/74377843/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="167878948" href="https://independent.academia.edu/RidaAli67">Rida Ali</a><script data-card-contents-for-user="167878948" type="text/json">{"id":167878948,"first_name":"Rida","last_name":"Ali","domain_name":"independent","page_name":"RidaAli67","display_name":"Rida Ali","profile_url":"https://independent.academia.edu/RidaAli67?f_ri=2018875","photo":"https://0.academia-photos.com/167878948/96023201/85044863/s65_rida.ali.jpeg"}</script></span></span></li><li class="js-paper-rank-work_61311975 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="61311975"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 61311975, container: ".js-paper-rank-work_61311975", }); 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$(".js-view-count[data-work-id=61311975]").text(description); $(".js-view-count-work_61311975").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_61311975").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="61311975"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="626" rel="nofollow" href="https://www.academia.edu/Documents/in/Oncology">Oncology</a>, <script data-card-contents-for-ri="626" type="text/json">{"id":626,"name":"Oncology","url":"https://www.academia.edu/Documents/in/Oncology?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6021" rel="nofollow" href="https://www.academia.edu/Documents/in/Cancer">Cancer</a>, <script data-card-contents-for-ri="6021" type="text/json">{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="24355" rel="nofollow" href="https://www.academia.edu/Documents/in/Carcinology">Carcinology</a>, <script data-card-contents-for-ri="24355" type="text/json">{"id":24355,"name":"Carcinology","url":"https://www.academia.edu/Documents/in/Carcinology?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="371491" rel="nofollow" href="https://www.academia.edu/Documents/in/Carcinoma">Carcinoma</a><script data-card-contents-for-ri="371491" type="text/json">{"id":371491,"name":"Carcinoma","url":"https://www.academia.edu/Documents/in/Carcinoma?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=61311975]'), work: {"id":61311975,"title":"Anticancer activity of milk fat rich in conjugated linoleic acid against Ehrlich ascites carcinoma cells in female Swiss albino mice","created_at":"2021-11-08T05:51:08.606-08:00","url":"https://www.academia.edu/61311975/Anticancer_activity_of_milk_fat_rich_in_conjugated_linoleic_acid_against_Ehrlich_ascites_carcinoma_cells_in_female_Swiss_albino_mice?f_ri=2018875","dom_id":"work_61311975","summary":"Background and Aim: The major conjugated linoleic acid (CLA) isomers have anticancer effect, especially breast cancer cells, inhibits cell growth and induces cell death. Also, CLA has several health benefits in vivo, including antiatherogenesis, antiobesity, and modulation of immune function. The present study aimed to assess the safety and anticancer effects of milk fat CLA against in vivo Ehrlich ascites carcinoma (EAC) in female Swiss albino mice. This was based on acute toxicity study, detection of the tumor growth, life span of EAC bearing hosts, and simultaneous alterations in the hematological, biochemical, and histopathological profiles. Materials and Methods: One hundred and fifty adult female mice were equally divided into five groups. Groups (1-2) were normal controls, and Groups (3-5) were tumor transplanted mice (TTM) inoculated intraperitoneally with EAC cells (2×106/0.2 mL). Group (3) was (TTM positive control). Group (4) TTM fed orally on balanced diet supplemented w...","downloadable_attachments":[{"id":74377843,"asset_id":61311975,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":167878948,"first_name":"Rida","last_name":"Ali","domain_name":"independent","page_name":"RidaAli67","display_name":"Rida Ali","profile_url":"https://independent.academia.edu/RidaAli67?f_ri=2018875","photo":"https://0.academia-photos.com/167878948/96023201/85044863/s65_rida.ali.jpeg"}],"research_interests":[{"id":626,"name":"Oncology","url":"https://www.academia.edu/Documents/in/Oncology?f_ri=2018875","nofollow":true},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=2018875","nofollow":true},{"id":24355,"name":"Carcinology","url":"https://www.academia.edu/Documents/in/Carcinology?f_ri=2018875","nofollow":true},{"id":371491,"name":"Carcinoma","url":"https://www.academia.edu/Documents/in/Carcinoma?f_ri=2018875","nofollow":true},{"id":1117458,"name":"March","url":"https://www.academia.edu/Documents/in/March?f_ri=2018875"},{"id":1683059,"name":"Conjugated linoleic acid","url":"https://www.academia.edu/Documents/in/Conjugated_linoleic_acid?f_ri=2018875"},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"},{"id":2754237,"name":"Ehrlich Ascites Carcinoma","url":"https://www.academia.edu/Documents/in/Ehrlich_Ascites_Carcinoma?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_81026816" data-work_id="81026816" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/81026816/New_Adamantane_Phenylalkylamines_with_%CF%83_Receptor_Binding_Affinity_and_Anticancer_Activity_Associated_with_Putative_Antagonism_of_Neuropathic_Pain">New Adamantane Phenylalkylamines with σ-Receptor Binding Affinity and Anticancer Activity, Associated with Putative Antagonism of Neuropathic Pain</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The synthesis of the adamantane phenylalkylamines 2a−d, 3a−c, and 4a−e is described. These compounds exhibited significant antiproliferative activity, in vitro, against eight cancer cell lines tested. The σ 1 , σ 2 , and sodium channel... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_81026816" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The synthesis of the adamantane phenylalkylamines 2a−d, 3a−c, and 4a−e is described. These compounds exhibited significant antiproliferative activity, in vitro, against eight cancer cell lines tested. The σ 1 , σ 2 , and sodium channel binding affinities of compounds 2a, 3a, 4a, and 4c−e were investigated. The most interesting analogue, 4a, exhibited significant in vivo anticancer profile on pancreas, prostate, leukemia, and ovarian cancer cell line xenografts together with apoptosis and caspase-3 activation. Inhibition of the cancer cells cycle at the sub-G1 level was also obtained with 4a. Finally, encouraging results were observed with 4a in vivo on mice, suggesting putative antimetastatic and analgesic activities of this compound.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/81026816" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="bc8379cf37ca5c557de4f4a38d979d33" rel="nofollow" data-download="{"attachment_id":87213413,"asset_id":81026816,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/87213413/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="56984069" href="https://independent.academia.edu/VassiliosMoutsos">Vassilios Moutsos</a><script data-card-contents-for-user="56984069" type="text/json">{"id":56984069,"first_name":"Vassilios","last_name":"Moutsos","domain_name":"independent","page_name":"VassiliosMoutsos","display_name":"Vassilios Moutsos","profile_url":"https://independent.academia.edu/VassiliosMoutsos?f_ri=2018875","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_81026816 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="81026816"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 81026816, container: ".js-paper-rank-work_81026816", }); 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$(".js-view-count[data-work-id=81026816]").text(description); $(".js-view-count-work_81026816").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_81026816").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="81026816"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="145" rel="nofollow" href="https://www.academia.edu/Documents/in/Biochemistry">Biochemistry</a>, <script data-card-contents-for-ri="145" type="text/json">{"id":145,"name":"Biochemistry","url":"https://www.academia.edu/Documents/in/Biochemistry?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="523" rel="nofollow" href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a>, <script data-card-contents-for-ri="523" type="text/json">{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="619" rel="nofollow" href="https://www.academia.edu/Documents/in/Hematology">Hematology</a>, <script data-card-contents-for-ri="619" type="text/json">{"id":619,"name":"Hematology","url":"https://www.academia.edu/Documents/in/Hematology?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2375" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicinal_Chemistry">Medicinal Chemistry</a><script data-card-contents-for-ri="2375" type="text/json">{"id":2375,"name":"Medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Medicinal_Chemistry?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=81026816]'), work: {"id":81026816,"title":"New Adamantane Phenylalkylamines with σ-Receptor Binding Affinity and Anticancer Activity, Associated with Putative Antagonism of Neuropathic Pain","created_at":"2022-06-08T10:38:31.956-07:00","url":"https://www.academia.edu/81026816/New_Adamantane_Phenylalkylamines_with_%CF%83_Receptor_Binding_Affinity_and_Anticancer_Activity_Associated_with_Putative_Antagonism_of_Neuropathic_Pain?f_ri=2018875","dom_id":"work_81026816","summary":"The synthesis of the adamantane phenylalkylamines 2a−d, 3a−c, and 4a−e is described. These compounds exhibited significant antiproliferative activity, in vitro, against eight cancer cell lines tested. The σ 1 , σ 2 , and sodium channel binding affinities of compounds 2a, 3a, 4a, and 4c−e were investigated. The most interesting analogue, 4a, exhibited significant in vivo anticancer profile on pancreas, prostate, leukemia, and ovarian cancer cell line xenografts together with apoptosis and caspase-3 activation. Inhibition of the cancer cells cycle at the sub-G1 level was also obtained with 4a. Finally, encouraging results were observed with 4a in vivo on mice, suggesting putative antimetastatic and analgesic activities of this compound.","downloadable_attachments":[{"id":87213413,"asset_id":81026816,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":56984069,"first_name":"Vassilios","last_name":"Moutsos","domain_name":"independent","page_name":"VassiliosMoutsos","display_name":"Vassilios Moutsos","profile_url":"https://independent.academia.edu/VassiliosMoutsos?f_ri=2018875","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":145,"name":"Biochemistry","url":"https://www.academia.edu/Documents/in/Biochemistry?f_ri=2018875","nofollow":true},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry?f_ri=2018875","nofollow":true},{"id":619,"name":"Hematology","url":"https://www.academia.edu/Documents/in/Hematology?f_ri=2018875","nofollow":true},{"id":2375,"name":"Medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Medicinal_Chemistry?f_ri=2018875","nofollow":true},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=2018875"},{"id":9113,"name":"Cell Cycle","url":"https://www.academia.edu/Documents/in/Cell_Cycle?f_ri=2018875"},{"id":13827,"name":"Cell Biology","url":"https://www.academia.edu/Documents/in/Cell_Biology?f_ri=2018875"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=2018875"},{"id":247477,"name":"Caspase","url":"https://www.academia.edu/Documents/in/Caspase?f_ri=2018875"},{"id":251671,"name":"Compounds","url":"https://www.academia.edu/Documents/in/Compounds?f_ri=2018875"},{"id":319664,"name":"Cancer Cell Lines","url":"https://www.academia.edu/Documents/in/Cancer_Cell_Lines?f_ri=2018875"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation?f_ri=2018875"},{"id":1114941,"name":"Antiproliferative Activity","url":"https://www.academia.edu/Documents/in/Antiproliferative_Activity?f_ri=2018875"},{"id":1190805,"name":"Adamantane","url":"https://www.academia.edu/Documents/in/Adamantane?f_ri=2018875"},{"id":1212103,"name":"Antineoplastic Agents","url":"https://www.academia.edu/Documents/in/Antineoplastic_Agents?f_ri=2018875"},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_80993298" data-work_id="80993298" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/80993298/New_Adamantane_Phenylalkylamines_with_%CF%83_Receptor_Binding_Affinity_and_Anticancer_Activity_Associated_with_Putative_Antagonism_of_Neuropathic_Pain">New Adamantane Phenylalkylamines with σ-Receptor Binding Affinity and Anticancer Activity, Associated with Putative Antagonism of Neuropathic Pain</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The synthesis of the adamantane phenylalkylamines 2a−d, 3a−c, and 4a−e is described. These compounds exhibited significant antiproliferative activity, in vitro, against eight cancer cell lines tested. The σ 1 , σ 2 , and sodium channel... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_80993298" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The synthesis of the adamantane phenylalkylamines 2a−d, 3a−c, and 4a−e is described. These compounds exhibited significant antiproliferative activity, in vitro, against eight cancer cell lines tested. The σ 1 , σ 2 , and sodium channel binding affinities of compounds 2a, 3a, 4a, and 4c−e were investigated. The most interesting analogue, 4a, exhibited significant in vivo anticancer profile on pancreas, prostate, leukemia, and ovarian cancer cell line xenografts together with apoptosis and caspase-3 activation. Inhibition of the cancer cells cycle at the sub-G1 level was also obtained with 4a. Finally, encouraging results were observed with 4a in vivo on mice, suggesting putative antimetastatic and analgesic activities of this compound.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/80993298" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="89e4e17dad35f504fb5dcfc805367e9c" rel="nofollow" data-download="{"attachment_id":87190418,"asset_id":80993298,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/87190418/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38105819" href="https://en-uoa-gr.academia.edu/IoaPapanastasiou">Ioannis P . Papanastasiou</a><script data-card-contents-for-user="38105819" type="text/json">{"id":38105819,"first_name":"Ioannis","last_name":"Papanastasiou","domain_name":"en-uoa-gr","page_name":"IoaPapanastasiou","display_name":"Ioannis P . 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These compounds exhibited significant antiproliferative activity, in vitro, against eight cancer cell lines tested. The σ 1 , σ 2 , and sodium channel binding affinities of compounds 2a, 3a, 4a, and 4c−e were investigated. The most interesting analogue, 4a, exhibited significant in vivo anticancer profile on pancreas, prostate, leukemia, and ovarian cancer cell line xenografts together with apoptosis and caspase-3 activation. Inhibition of the cancer cells cycle at the sub-G1 level was also obtained with 4a. Finally, encouraging results were observed with 4a in vivo on mice, suggesting putative antimetastatic and analgesic activities of this compound.","downloadable_attachments":[{"id":87190418,"asset_id":80993298,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38105819,"first_name":"Ioannis","last_name":"Papanastasiou","domain_name":"en-uoa-gr","page_name":"IoaPapanastasiou","display_name":"Ioannis P . Papanastasiou","profile_url":"https://en-uoa-gr.academia.edu/IoaPapanastasiou?f_ri=2018875","photo":"https://0.academia-photos.com/38105819/15603736/16183096/s65_ioannis.papanastasiou.jpg"}],"research_interests":[{"id":145,"name":"Biochemistry","url":"https://www.academia.edu/Documents/in/Biochemistry?f_ri=2018875","nofollow":true},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry?f_ri=2018875","nofollow":true},{"id":619,"name":"Hematology","url":"https://www.academia.edu/Documents/in/Hematology?f_ri=2018875","nofollow":true},{"id":2375,"name":"Medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Medicinal_Chemistry?f_ri=2018875","nofollow":true},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=2018875"},{"id":9113,"name":"Cell Cycle","url":"https://www.academia.edu/Documents/in/Cell_Cycle?f_ri=2018875"},{"id":13827,"name":"Cell Biology","url":"https://www.academia.edu/Documents/in/Cell_Biology?f_ri=2018875"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=2018875"},{"id":247477,"name":"Caspase","url":"https://www.academia.edu/Documents/in/Caspase?f_ri=2018875"},{"id":251671,"name":"Compounds","url":"https://www.academia.edu/Documents/in/Compounds?f_ri=2018875"},{"id":319664,"name":"Cancer Cell Lines","url":"https://www.academia.edu/Documents/in/Cancer_Cell_Lines?f_ri=2018875"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation?f_ri=2018875"},{"id":1114941,"name":"Antiproliferative Activity","url":"https://www.academia.edu/Documents/in/Antiproliferative_Activity?f_ri=2018875"},{"id":1190805,"name":"Adamantane","url":"https://www.academia.edu/Documents/in/Adamantane?f_ri=2018875"},{"id":1212103,"name":"Antineoplastic Agents","url":"https://www.academia.edu/Documents/in/Antineoplastic_Agents?f_ri=2018875"},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_68895958" data-work_id="68895958" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/68895958/Anticancer_activity_of_large_metalla_assemblies_built_from_half_sandwich_complexes">Anticancer activity of large metalla-assemblies built from half-sandwich complexes</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Figure S1: Electrospray ionization mass spectrum of [1][CF 3 SO 3 ] 8 .</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/68895958" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2ad456e47d9ecb1a674112658bdf829e" rel="nofollow" data-download="{"attachment_id":79205424,"asset_id":68895958,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/79205424/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span 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u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="56" rel="nofollow" href="https://www.academia.edu/Documents/in/Materials_Engineering">Materials Engineering</a>, <script data-card-contents-for-ri="56" type="text/json">{"id":56,"name":"Materials Engineering","url":"https://www.academia.edu/Documents/in/Materials_Engineering?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="530" rel="nofollow" href="https://www.academia.edu/Documents/in/Inorganic_Chemistry">Inorganic Chemistry</a>, <script data-card-contents-for-ri="530" type="text/json">{"id":530,"name":"Inorganic Chemistry","url":"https://www.academia.edu/Documents/in/Inorganic_Chemistry?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2018875" rel="nofollow" href="https://www.academia.edu/Documents/in/Anticancer_activity">Anticancer activity</a><script data-card-contents-for-ri="2018875" type="text/json">{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=68895958]'), work: {"id":68895958,"title":"Anticancer activity of large metalla-assemblies built from half-sandwich complexes","created_at":"2022-01-20T16:28:30.964-08:00","url":"https://www.academia.edu/68895958/Anticancer_activity_of_large_metalla_assemblies_built_from_half_sandwich_complexes?f_ri=2018875","dom_id":"work_68895958","summary":"Figure S1: Electrospray ionization mass spectrum of [1][CF 3 SO 3 ] 8 .","downloadable_attachments":[{"id":79205424,"asset_id":68895958,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":78521017,"first_name":"Nagesh","last_name":"Narayana","domain_name":"davike-cae","page_name":"NageshNarayana","display_name":"Nagesh Narayana","profile_url":"https://davike-cae.academia.edu/NageshNarayana?f_ri=2018875","photo":"https://0.academia-photos.com/78521017/21457831/20840943/s65_nagesh.narayana.jpg"}],"research_interests":[{"id":56,"name":"Materials Engineering","url":"https://www.academia.edu/Documents/in/Materials_Engineering?f_ri=2018875","nofollow":true},{"id":530,"name":"Inorganic Chemistry","url":"https://www.academia.edu/Documents/in/Inorganic_Chemistry?f_ri=2018875","nofollow":true},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_42982800" data-work_id="42982800" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/42982800/Synthesis_and_Characterization_of_Novel_N_Benzylbenzimidazole_Linked_Pyrimidine_Derivatives_as_Anticancer_Agents">Synthesis and Characterization of Novel N-Benzylbenzimidazole Linked Pyrimidine Derivatives as Anticancer Agents</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Emergence of resistance to accessible anticancer drugs became a threat to human lives in the recent time. To address this issue, discovery of novel anticancer agents becomes very essential. Benzimidazoles and pyrimidines have... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_42982800" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Emergence of resistance to accessible anticancer drugs became a threat to human lives in the recent time. To address this issue, discovery of novel anticancer agents becomes very essential. Benzimidazoles and pyrimidines have been reported to possess potent anticancer activity. Material and Methods: A hybrid approach has been used, in which core structure of potentially active N-benzyl benzimidazole and pyrimidine derivatives are brought together in to a single molecule. The desired compounds were prepared by the condensation of N-benzyl benzimidazole chalcones with guanidine hydrochloride. The synthesized compounds were characterized using spectral studies (IR, 1H, 13C-NMR techniques and mass spectrometry). All the compounds were screened for their anticancer activity against human breast cancer cell line MDA-MB-231. Results: The spectral data’s are in well agreement with the synthesized compounds 5a-e. Compounds 5b (GI50 = 39.6 μM) and 5a (GI50=84.0 μM) exhibited significant anticancer activity. Conclusion: Owing to the anticancer activity, compound 5b can be used as lead structure in the development of yet more potent anticancer agents.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/42982800" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="59264507f45c5e9b25b4da9496f6c260" rel="nofollow" data-download="{"attachment_id":63242985,"asset_id":42982800,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/63242985/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="13713939" href="https://cutm.academia.edu/GopalKrishnaPadhy">Gopal Krishna Padhy</a><script data-card-contents-for-user="13713939" type="text/json">{"id":13713939,"first_name":"Gopal Krishna","last_name":"Padhy","domain_name":"cutm","page_name":"GopalKrishnaPadhy","display_name":"Gopal Krishna Padhy","profile_url":"https://cutm.academia.edu/GopalKrishnaPadhy?f_ri=2018875","photo":"https://0.academia-photos.com/13713939/3815633/34787312/s65_gopal_krishna.padhy.jpg"}</script></span></span></li><li class="js-paper-rank-work_42982800 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="42982800"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 42982800, container: ".js-paper-rank-work_42982800", }); });</script></li><li class="js-percentile-work_42982800 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 42982800; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_42982800"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_42982800 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="42982800"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 42982800; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=42982800]").text(description); $(".js-view-count-work_42982800").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_42982800").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="42982800"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="425464" rel="nofollow" href="https://www.academia.edu/Documents/in/Pyrimidine">Pyrimidine</a>, <script data-card-contents-for-ri="425464" type="text/json">{"id":425464,"name":"Pyrimidine","url":"https://www.academia.edu/Documents/in/Pyrimidine?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="1003055" rel="nofollow" href="https://www.academia.edu/Documents/in/Anticancer_Agents">Anticancer Agents</a>, <script data-card-contents-for-ri="1003055" type="text/json">{"id":1003055,"name":"Anticancer Agents","url":"https://www.academia.edu/Documents/in/Anticancer_Agents?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2018875" rel="nofollow" href="https://www.academia.edu/Documents/in/Anticancer_activity">Anticancer activity</a><script data-card-contents-for-ri="2018875" type="text/json">{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=42982800]'), work: {"id":42982800,"title":"Synthesis and Characterization of Novel N-Benzylbenzimidazole Linked Pyrimidine Derivatives as Anticancer Agents","created_at":"2020-05-08T12:00:24.442-07:00","url":"https://www.academia.edu/42982800/Synthesis_and_Characterization_of_Novel_N_Benzylbenzimidazole_Linked_Pyrimidine_Derivatives_as_Anticancer_Agents?f_ri=2018875","dom_id":"work_42982800","summary":"Background: Emergence of resistance to accessible anticancer drugs became a threat to human lives in the recent time. To address this issue, discovery of novel anticancer agents becomes very essential. Benzimidazoles and pyrimidines have been reported to possess potent anticancer activity. Material and Methods: A hybrid approach has been used, in which core structure of potentially active N-benzyl benzimidazole and pyrimidine derivatives are brought together in to a single molecule. The desired compounds were prepared by the condensation of N-benzyl benzimidazole chalcones with guanidine hydrochloride. The synthesized compounds were characterized using spectral studies (IR, 1H, 13C-NMR techniques and mass spectrometry). All the compounds were screened for their anticancer activity against human breast cancer cell line MDA-MB-231. Results: The spectral data’s are in well agreement with the synthesized compounds 5a-e. Compounds 5b (GI50 = 39.6 μM) and 5a (GI50=84.0 μM) exhibited significant anticancer activity. Conclusion: Owing to the anticancer activity, compound 5b can be used as lead structure in the development of yet more potent anticancer agents.","downloadable_attachments":[{"id":63242985,"asset_id":42982800,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":13713939,"first_name":"Gopal Krishna","last_name":"Padhy","domain_name":"cutm","page_name":"GopalKrishnaPadhy","display_name":"Gopal Krishna Padhy","profile_url":"https://cutm.academia.edu/GopalKrishnaPadhy?f_ri=2018875","photo":"https://0.academia-photos.com/13713939/3815633/34787312/s65_gopal_krishna.padhy.jpg"}],"research_interests":[{"id":425464,"name":"Pyrimidine","url":"https://www.academia.edu/Documents/in/Pyrimidine?f_ri=2018875","nofollow":true},{"id":1003055,"name":"Anticancer Agents","url":"https://www.academia.edu/Documents/in/Anticancer_Agents?f_ri=2018875","nofollow":true},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_33098176" data-work_id="33098176" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/33098176/Garlic_Phytocompounds_Possess_Anticancer_Activity_by_Specifically_Targeting_Breast_Cancer_Biomarkers_an_in_Silico_Study">Garlic Phytocompounds Possess Anticancer Activity by Specifically Targeting Breast Cancer Biomarkers - an in Silico Study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Breast cancer (BC) is a serious lifestyle disease. There are several prognostic biomarkers like nuclear receptors whose over-expression is associated with BC characteristics. These biomarkers can be blocked by compounds with... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_33098176" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Breast cancer (BC) is a serious lifestyle disease. There are several prognostic biomarkers like nuclear receptors whose over-expression is associated with BC characteristics. These biomarkers can be blocked by compounds with anti-cancer potential but selection must be made on the basis of no adverse side effects. This study is focused on finding of compounds from a plant material, garlic. Materials and Methods: Twenty compounds from garlic and five targets considered involved in BC were retrieved from Pubchem database and Protein Data Bank respectively. They are docked using Accelrys Discovery Studio (DS) 4.0. The compounds which showed interaction were checked for drug likeliness. Results: Docking studies and ADMET evaluation revealed twelve compounds to be active against the targets. All the compounds displayed highly negative dock scores which indicated good interactions. Conclusions: The results of this study should help researchers and scientists in the pharmaceutical field to identify drugs based on garlic.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/33098176" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5803a174b8a112112168082cfad0ddca" rel="nofollow" data-download="{"attachment_id":53196008,"asset_id":33098176,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/53196008/download_file?st=MTc0MDUwOTI0MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="24615833" href="https://independent.academia.edu/ArunaksharanN">Arunaksharan N</a><script data-card-contents-for-user="24615833" type="text/json">{"id":24615833,"first_name":"Arunaksharan","last_name":"N","domain_name":"independent","page_name":"ArunaksharanN","display_name":"Arunaksharan N","profile_url":"https://independent.academia.edu/ArunaksharanN?f_ri=2018875","photo":"https://0.academia-photos.com/24615833/6657923/17030675/s65_arunaksharan.n.png"}</script></span></span></li><li class="js-paper-rank-work_33098176 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="33098176"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 33098176, container: ".js-paper-rank-work_33098176", }); });</script></li><li class="js-percentile-work_33098176 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 33098176; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_33098176"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_33098176 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="33098176"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 33098176; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=33098176]").text(description); $(".js-view-count-work_33098176").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_33098176").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="33098176"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="6802" rel="nofollow" href="https://www.academia.edu/Documents/in/Breast_Cancer">Breast Cancer</a>, <script data-card-contents-for-ri="6802" type="text/json">{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="269567" rel="nofollow" href="https://www.academia.edu/Documents/in/Garlic">Garlic</a>, <script data-card-contents-for-ri="269567" type="text/json">{"id":269567,"name":"Garlic","url":"https://www.academia.edu/Documents/in/Garlic?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="964268" rel="nofollow" href="https://www.academia.edu/Documents/in/In_silico_ADMET">In silico ADMET</a>, <script data-card-contents-for-ri="964268" type="text/json">{"id":964268,"name":"In silico ADMET","url":"https://www.academia.edu/Documents/in/In_silico_ADMET?f_ri=2018875","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2018875" rel="nofollow" href="https://www.academia.edu/Documents/in/Anticancer_activity">Anticancer activity</a><script data-card-contents-for-ri="2018875" type="text/json">{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=33098176]'), work: {"id":33098176,"title":"Garlic Phytocompounds Possess Anticancer Activity by Specifically Targeting Breast Cancer Biomarkers - an in Silico Study","created_at":"2017-05-19T07:09:18.447-07:00","url":"https://www.academia.edu/33098176/Garlic_Phytocompounds_Possess_Anticancer_Activity_by_Specifically_Targeting_Breast_Cancer_Biomarkers_an_in_Silico_Study?f_ri=2018875","dom_id":"work_33098176","summary":"Background: Breast cancer (BC) is a serious lifestyle disease. There are several prognostic biomarkers like nuclear receptors whose over-expression is associated with BC characteristics. These biomarkers can be blocked by compounds with anti-cancer potential but selection must be made on the basis of no adverse side effects. This study is focused on finding of compounds from a plant material, garlic. Materials and Methods: Twenty compounds from garlic and five targets considered involved in BC were retrieved from Pubchem database and Protein Data Bank respectively. They are docked using Accelrys Discovery Studio (DS) 4.0. The compounds which showed interaction were checked for drug likeliness. Results: Docking studies and ADMET evaluation revealed twelve compounds to be active against the targets. All the compounds displayed highly negative dock scores which indicated good interactions. Conclusions: The results of this study should help researchers and scientists in the pharmaceutical field to identify drugs based on garlic. \n","downloadable_attachments":[{"id":53196008,"asset_id":33098176,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":24615833,"first_name":"Arunaksharan","last_name":"N","domain_name":"independent","page_name":"ArunaksharanN","display_name":"Arunaksharan N","profile_url":"https://independent.academia.edu/ArunaksharanN?f_ri=2018875","photo":"https://0.academia-photos.com/24615833/6657923/17030675/s65_arunaksharan.n.png"}],"research_interests":[{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer?f_ri=2018875","nofollow":true},{"id":269567,"name":"Garlic","url":"https://www.academia.edu/Documents/in/Garlic?f_ri=2018875","nofollow":true},{"id":964268,"name":"In silico ADMET","url":"https://www.academia.edu/Documents/in/In_silico_ADMET?f_ri=2018875","nofollow":true},{"id":2018875,"name":"Anticancer activity","url":"https://www.academia.edu/Documents/in/Anticancer_activity?f_ri=2018875","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div></div><div class="u-taCenter Pagination"><ul class="pagination"></ul></div></div><div class="hidden-xs hidden-sm"><div class="u-pl6x"><div style="width: 300px;"></div></div></div></div></div><script>// MIT License // Copyright © 2011 Sebastian Tschan, https://blueimp.net // Permission is hereby granted, free of charge, to any person obtaining a copy of // this software and associated documentation files (the "Software"), to deal in // the Software without restriction, including without limitation the rights to // use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of // the Software, and to permit persons to whom the Software is furnished to do so, // subject to the following conditions: // The above copyright notice and this permission notice shall be included in all // copies or substantial portions of the Software. // THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR // IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS // FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. 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