Property Analysis Services - Creative Biolabs

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With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects. </p>  <b class="Highlights_tit">Highlights</b> <ul class="HighlightsArea"> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Solutions-menu-lights-pic-1.jpg" srcset="static/images/Solutions-menu-lights-pic-1.webp 1x" width="201" height="131" loading="lazy"><a href="discovery-services.html" class="bannerbutton"><i class="fa fa-angle-right"></i>Discovery Services</a> </li> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Solutions-menu-lights-pic-2.jpg" srcset="static/images/Solutions-menu-lights-pic-2.webp 1x" width="201" height="131" loading="lazy"><a href="engineering-services.html" class="bannerbutton"> <i class="fa fa-angle-right"></i>Engineering Services </a> </li> </ul> </li> </ul> </div> </div> </li> <li> <span>Characterization</span> <div class="secondMenu"> <div class="second-menu-area-box"> <ul style="margin-top:0;">  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We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects. </p> <b class="Highlights_tit">Highlights</b> <ul class="HighlightsArea"> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Abouts-menu-lights-pic-1.jpg" srcset="static/images/Abouts-menu-lights-pic-1.webp 1x" width="200" height="131" loading="lazy"><a href="aboutus.html" class="bannerbutton"> <i class="fa fa-angle-right"></i>About CBL </a> </li> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Abouts-menu-lights-pic-2.jpg" srcset="static/images/Abouts-menu-lights-pic-2.webp 1x" width="200" height="131" loading="lazy"><a href="contactus.html" class="bannerbutton"> <i class="fa fa-angle-right"></i>Contact Us </a> </li> </ul> </li> </ul> </div> </div> </li> </ul> <script> window.addEventListener('load',function(){ var arr = ['/drug-discovery/therapeutics/','/bioconjugation/','/adc/']; $('.mennav ul li a').each(function(){ var $this = $(this); var href = $this.attr("href").toLocaleLowerCase(); $.each(arr, function(index, value) { if (href && href.startsWith(value)) { $this.attr('target', '_blank'); } }); }); }); </script> </div> <div class="top-search search-group"> <div class="col-md-5 col-sm-6"> <label class="radio-inline"><input type="radio" name="search" class="rdo_productsearch" value="product" data-type="product" placeholder="Please input cat#, product name, abbr, or keywords."> Product</label> <label class="radio-inline"><input type="radio" name="search" class="rdo_servicesearch" value="service" data-type="service" placeholder="Please input your keywords."> Service</label> <label class="radio-inline"><input type="radio" name="search" class="rdo_googlesearch" value="google" data-type="google" placeholder="Please input your keywords." checked="checked"> Keyword</label> </div> <div class="col-md-7 col-sm-6 search-div"> <input id="keys" name="keys" placeholder="Please input your keywords." class="search-input"> <div class="selectItems"></div> <span class="search_btn"><i class="fa fa-search"></i></span> </div> </div> </div> <div class="searchShow"> <div class="searchtopbg"></div> <span class="searchclosed"><i class="fa fa-times"></i>Close</span> <div class="addsearch search-group"></div> </div> <div class="banner_inpage services_bg_2"> <div class="auto-container small_content-width about_container"> <ul class="bread-crumb clearfix"> <li><a href="/">Home</a></li> <li><a href="javascrpt:void(0)">Characterization</a></li> <li>Property Analysis</li> </ul> <p>"Creative Biolabs is committed to providing highly customized comprehensive solutions with the best quality to advance our global clients’ projects."</p> </div> </div> <script> window.addEventListener('load', function () { if (($('.bread-crumb li:last-child').text()) == "Peer-Reviewed Publications") { $(".banner_inpage").addClass("peer-reviewed-publications_bg").removeClass("services_bg_2"); } if ($(window).hasClass('bread-crumb')) { if ($(".bread-crumb").html().indexOf("RESOURCE") > -1) { $(".pronote").hide(); } if ($(".bread-crumb").html().indexOf("Careers") > -1) { $(".pronote").hide(); } } }); </script> <div class="small_content-width services-container"> <div class="col-md-9"> <div class="inpage_section_title"> <h1>Property Analysis Services</h1> </div> <div class="page-tab"> <span onclick="window.location.href=window.location.pathname+'#tab1'">Background</span> <span onclick="window.location.href=window.location.pathname+'#tab2'">Services</span> <span onclick="window.location.href=window.location.pathname+'#tab3'">Published Data</span> <span onclick="window.location.href=window.location.pathname+'#tab4'">FAQ</span> <span onclick="window.location.href=window.location.pathname+'#tab5'">Resources</span> </div> <script> window.addEventListener('load',function(){ page_tab_margin() page_tab_css(); })</script> <p> <b>Creative Biolabs</b> provides a comprehensive antibody analysis services to make the best understanding for interested antibody property. We offer tailored solutions for antibody analysis to support drug discovery, manufacturing process and any other particular requirements. </p> <h2 class="h2_tit page_tab_margin" id="tab1"> Background </h2> <p> Antibody products, monoclonal antibody (mAb) especially, have played a major role of the growing biologics drug market. For the diagnosis and treatment of various disease types, the development of monoclonal antibody therapeutics is almost the largest and most effective choice for oncological, immunological and anti-infective therapeutic areas. One reason of this interest is due to the exquisite specificity of mAbs. In general, a particular antigen can be specifically bound by a monoclonal antibody which has structurally identical antigen-binding regions recognize the same site of the antigen. This specificity can lead to highly selective interactions with interested targets involved in the pathology of disease, such as receptors, tissues and organs, and further minimizing the potential side effects. </p> <p> While, the complex nature of antibody products presents a number of unique challenges during their development and manufacture of biopharmaceuticals. During the development and production of antibody based therapeutic drugs, it is essential to detect, characterize and quantify impurities as well as the important parameters about structural variants and modifications, affinity and immunogenicity to monitor the stability and safety of the final products. This physical truth has been emphasizing the need for innovative and efficient analytic tools and services. Fortunately, <strong>Creative Biolabs</strong> is just the chosen one who is able to meet clients' analytical needs by offering a wide range of services that have been specifically tailored to meet the quality analysis and high-throughput requirements of antibody therapeutic development projects. These services include <a href="/next-generation-antibody-sequencing.html"><i>de novo</i> antibody sequencing</a>, <a href="/Antibody-Affinity-Measurement.html">affinity measurement</a>, <a href="/Monoclonal-Antibody-Epitope-Binning.html">epitope binning</a>, <a href="/SIAT.html">immunogenicity assessment</a>, <a href="/Isothermal-Titration-Calorimetry-ITC-Service.html">isothermal titration calorimetry (ITC)</a>, <a href="/Differential-scanning-calorimetry-DSC-Service.html">differential scanning calorimetry (DSC)</a>, <a href="/Dual-Polarization-Interferometry-DPI-Services.html">dual-polarization interferometry (DPI)</a> and more. </p> <h2 class="h2_tit page_tab_margin" id="tab2"> Antibody Analysis Services </h2> <p> <b>Creative Biolabs</b> is a long-term expert who provide remarkable antibody related services. Our professional academic team have concentrated on the research and development of antibody realm for over decades and successfully contributed a range of services specifically tailored to antibody analytics. We are confident in applying our experience, industry and regulatory knowledge to design actual strategic packages pertinent to customers' project. </p> <p class="show-center"> <img loading="lazy" width="420" height="317" src="static/img/Antibody-Analysis-Services-1.jpg" alt="Phage Display & Antibody Library Services" /><strong>Fig. 1</strong> Antibody Basics. </p> <p> Learn more about Antibody Analysis Services: </p> <ul class="ullist"> <li> <a href="/antibody-characterization.html">Antibody Characterization</a> </li> <li> <a href="/Antibody-Affinity-Measurement.html">Antibody Affinity Measurement</a> </li> <li> <a href="/antibody-sequencing-service.html">Hybridoma Sequencing Service</a> </li> <li> <a href="/next-generation-antibody-sequencing.html"><em>De Novo</em> Antibody Sequencing Services</a> </li> <li> <a href="/precision-paratope-mapping-service.htm">Precision Paratope Mapping Service</a> </li> <li> <a href="/Monoclonal-Antibody-Epitope-Binning.html">Monoclonal Antibody Epitope Binning</a> </li> <li> <a href="/SPR-Services.html">SPR Services</a> </li> <li> <a href="/Isothermal-Titration-Calorimetry-ITC-Service.html">Isothermal Titration Calorimetry (ITC) Services</a> </li> <li> <a href="/Differential-scanning-calorimetry-DSC-Service.html">Differential Scanning Calorimetry (DSC) Services</a> </li> <li> <a href="/Dual-Polarization-Interferometry-DPI-Services.html">Dual-Polarization Interferometry (DPI) Services</a> </li> </ul> <h2 class="h2_tit page_tab_margin" id="tab3"> Published Data </h2> <ul class="ullist"> <li> <strong>An Anti-All Influenza A Subtype Antibody Structure and Function Analysis</strong> </li> </ul> <p class="show-center"> <img loading="lazy" src="/static/img/1-2-3-antibody-analysis-services-2.jpg" width="400" height="448" alt="" />Fig. 2 Affinity Maturation Pathway of the FI6 Lineage Mutated Antibodies. (Nicole L. Kallewaard, 2016) </p> <p> Influenza viruses can escape the vaccine-induced immune response caused by antigen drift. Here, the researchers described the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody MEDI8852, which reacts effectively with all influenza A hemagglutinin (HA) subtypes. MEDI8852 uses the heavy chain VH6-1 gene, which has high potency and breadth. At the same time, the antibody is effective in mice and ferrets. Fab crystallographic analysis of single or complex H5 or H7 HA proteins showed that MEDI8852 binds to a highly conserved epitope through coordinated movement of CDR, which contains hydrophobic grooves in the fusion domain and most of the fusion peptides, which makes it different from other structural feature cross-reactive antibodies. The results show that the neutralization breadth and efficacy of MEDI8852 make it have great potential in immunotherapy for influenza virus infection. </p> <div class="reference"> <strong>Reference</strong> <ol class="ollist decimal"> <li> Kallewaard, Nicole L., et al. "Structure and function analysis of an antibody recognizing all influenza A subtypes." <em>Cell</em> 166.3 (2016): 596-608. </li> </ol> </div> <script type="text/javascript"> window.addEventListener('load',function(){ faqlist(4); }); </script> <h2 class="h2_tit page_tab_margin" id="tab4"> FAQ </h2> <ol class="ollist faqlist"> <li> <span class="sFAQTit">What is antibody analysis and why is it important?</span> <p> Antibody analysis involves various techniques to study and evaluate antibodies, which are proteins produced by the immune system in response to foreign substances known as antigens. This analysis is critical in research, diagnostic, and therapeutic applications. It helps in understanding immune responses, developing vaccines, diagnosing diseases, and creating antibody-based treatments. </p> </li> <li> <span class="sFAQTit">What are the key factors that affect the performance of antibodies in analysis?</span> <p> Several factors influence the performance of antibodies in analytical applications, including affinity, specificity, cross-reactivity, and the physical condition of the antibody. Affinity refers to the strength of the bond between an antibody and its antigen, which affects the sensitivity of detection. Specificity is crucial for ensuring that the antibody binds only to the target antigen and not to other molecules, reducing false-positive results. Cross-reactivity, where an antibody reacts with antigens similar to the target, can lead to nonspecific binding and inaccurate results. Finally, the physical condition of the antibody, such as its purity, concentration, and storage conditions, also plays a critical role in its effectiveness in various assays. </p> </li> <li> <span class="sFAQTit">How does the development of recombinant antibodies impact antibody analysis?</span> <p> Unlike traditional monoclonal and polyclonal antibodies, which are derived from animals, recombinant antibodies are produced using genetic engineering techniques. This process ensures that antibodies have uniform specificity and affinity, as they are cloned from a single sequence. Recombinant antibodies can be produced in large quantities without batch-to-batch variation, enhancing the reliability of experimental results. Additionally, the ability to modify the antibody structure (e.g., humanization, affinity maturation) in recombinant antibodies allows for customized antibody engineering to suit specific analytical needs, reducing cross-reactivity and improving overall assay performance. </p> </li> <li> <span class="sFAQTit">How does antibody analysis facilitate the development of therapeutic antibodies?</span> <p> Antibody analysis is integral to the development of therapeutic antibodies as it enables the identification and characterization of candidates with the desired biological activity and specificity. During therapeutic development, antibodies are screened for their ability to bind specifically to target antigens without cross-reacting with other molecules. Techniques such as surface plasmon resonance (SPR) and bio-layer interferometry (BLI) are used to measure the affinity and kinetics of antibody-antigen interactions. Additionally, functional assays, such as cell-based assays, are employed to assess the biological activity of antibodies, ensuring they elicit the intended therapeutic response, such as inducing or blocking a signaling pathway. </p> </li> <li> <span class="sFAQTit">What role does antibody engineering play in optimizing antibodies for therapeutic use?</span> <p> Antibody engineering is a crucial step in optimizing antibodies for therapeutic use, enhancing their efficacy, safety, and stability. Techniques such as humanization and affinity maturation are employed to reduce immunogenicity and improve binding affinity, respectively. Humanization involves modifying a non-human antibody (often from mice) to make it more similar to human antibodies, thereby reducing the likelihood of immune responses in patients. Affinity maturation further enhances an antibody's ability to bind to its target, which can increase therapeutic efficacy. Additionally, engineering efforts can modify the Fc (fragment crystallizable) region of antibodies to alter their half-life, effector functions, and distribution within the body, tailoring them to specific therapeutic needs. These engineering strategies ensure that therapeutic antibodies are both effective against their targets and compatible with human use, thereby meeting the stringent requirements of therapeutic development projects. </p> </li> <li> <span class="sFAQTit">How does antibody analysis contribute to the scalability of antibody production in therapeutic projects?</span> <p> Antibody analysis is crucial for scaling up the production of therapeutic antibodies. During scale-up, maintaining the consistency and quality of antibodies is essential. Analytical techniques are used to monitor the production process to ensure that each batch of antibodies meets the defined characteristics for therapeutic use. Methods such as HPLC (High-Performance Liquid Chromatography) and SDS-PAGE (Sodium Dodecyl Sulphate Polyacrylamide Gel Electrophoresis) are employed to assess the purity and structural integrity of the antibodies. Additionally, functional assays are used throughout the production process to verify the biological activity of the antibodies. By integrating these analytical methods, manufacturers can effectively scale up antibody production while ensuring that the therapeutic antibodies retain their intended efficacy and safety profiles. This is pivotal not only for regulatory approval but also for the successful commercialization of the therapy. </p> </li> <li> <span class="sFAQTit">What is the role of immunogenicity testing in antibody therapeutic development?</span> <p> Immunogenicity testing is a critical component of antibody therapeutic development, aimed at assessing the potential of therapeutic antibodies to elicit immune responses in patients. This testing is crucial because even humanized or fully human antibodies can trigger immune reactions, which may reduce the therapeutic efficacy or lead to adverse effects. Techniques such as ELISPOT and enzyme-linked immunosorbent assays (ELISA) are used to detect and quantify anti-drug antibodies (ADAs) that a patient's immune system might develop against the therapeutic antibody. Additionally, in silico tools can predict epitopes likely to be immunogenic. By performing comprehensive immunogenicity testing, developers can modify antibodies to reduce their immunogenic potential, thereby enhancing their safety and effectiveness in clinical settings. </p> </li> <li> <span class="sFAQTit">How does stability testing fit into antibody analysis for therapeutic development?</span> <p> Stability testing is an essential part of antibody analysis for therapeutic development, ensuring that antibody products maintain their intended physical, chemical, and biological characteristics over time under various conditions. This testing involves evaluating the antibody's resistance to aggregation, degradation, and changes in conformation and binding affinity under different temperatures, pH levels, and other environmental factors. Techniques such as differential scanning calorimetry (DSC), size-exclusion chromatography (SEC), and real-time stability studies provide insights into the conditions that antibodies can withstand during storage, handling, and administration. Stability testing not only helps in determining optimal storage conditions and shelf life but is also critical for regulatory compliance, as it demonstrates the robustness of the antibody formulation. </p> </li> </ol> <h2 class="h2_tit page_tab_margin" id="tab5"> Resources </h2> <p> Use the resources in our library to help you understand your options and make critical decisions for your study. </p> <div class="tab_nav"> <span class="tab_choosebg">Videos</span><span>Podcasts</span><span>Infographic</span><span>Flyer</span><span>Case study</span><span>Articles</span> </div>  <div class="tab_cont" style="display:block;"> <div class="row pagerow_pt"> <div class="col-md-4"> <div class="pagerow_pt_unit"> <img loading="lazy" src="../static/img/introduction-of-recombinant-antibody.jpg" alt="" /> </div> <a href="https://youtu.be/0-yZ9dTGg18" target="_blank">Introduction of Recombinant Antibody</a> </div> <div class="col-md-4"> <div class="pagerow_pt_unit"> <img loading="lazy" src="../static/img/immunogenicity-overview-of-therapeutic-biologics.jpg" alt="" /> </div> <a href="https://youtu.be/J430752_dTo" target="_blank">Immunogenicity overview of therapeutic biologics</a> </div> <div class="col-md-4"> <div class="pagerow_pt_unit"> <img loading="lazy" src="../static/img/video-development-of-monoclonal-antibodies-s.png" alt="" /> </div> <a href="https://youtu.be/NGqipRkxXiY" target="_blank">Antibody Library Screening - Creative Biolabs</a> </div> <div class="col-md-4"> <div class="pagerow_pt_unit"> <img loading="lazy" src="../static/img/antibody-based-cancer-therapies-creative-biolabs.jpg" alt="" /> </div> <a href="https://youtu.be/_Cqj5gphNug" target="_blank">Antibody based Cancer Therapies - Creative Biolabs</a> </div> <div class="col-md-4"> <div class="pagerow_pt_unit"> <img loading="lazy" src="../static/img/video-de-novo-antibody-sequencing-service.jpg" alt="" /> </div> <a href="https://youtu.be/lcdGTNKbaGQ" target="_blank"><em>De Novo</em> Antibody Sequencing Service</a> </div> <div class="col-md-4"> <div class="pagerow_pt_unit"> <img loading="lazy" src="../static/img/video-100-identification-of-leucine-and-isoleucine-in-de-novo-antibody-sequencing.jpg" alt="" /> </div> <a href="https://youtu.be/lcdGTNKbaGQ" target="_blank">100% Identification of Leucine and Isoleucine in <em>De Novo</em> Antibody Sequencing</a> </div> </div> </div>  <div class="tab_cont"> <div class="therapy_ad"> <a href="therapeutic-antibody.html"> <img loading="lazy" src="../static/img/podcasts-ad.png" width="1700" height="500" srcset="../static/img/podcasts-ad.webp 1x,../static/img/podcasts-ad.webp 2x,../static/img/podcasts-ad.webp 3x" alt="In this brand new podcast series, we will show you everything you want to know about CAR-T therapy, including the mechanism, current applications, technology limitations, and potential strategies." /></a> </div> </div>  <div class="tab_cont"> <div class="row pagerow_pt"> <div class="col-md-4"> <div class="pagerow_pt_unit_2"> <img loading="lazy" src="/resource/images/A-Brief-Introduction-to-Antibodies-1.jpg" width="600" height="500" alt="" /> </div> <a href="https://go.creative-biolabs.com/a-brief-introduction-to-antibodies.html">A Brief Introduction to Antibodies</a> </div> <div class="col-md-4"> <div class="pagerow_pt_unit_2"> <img loading="lazy" src="/resource/images/Antibody-Library-Screening-Creative-Biolabs.jpg" width="600" height="500" alt="" /> </div> <a href="https://go.creative-biolabs.com/antibody-library-screening.html ">Antibody Library Screening</a> </div> <div class="col-md-4"> <div class="pagerow_pt_unit_2"> <img loading="lazy" src="/resource/images/De-Novo-Antibody-Seuqencing-Service-Creative-Biolabs.jpg" width="600" height="500" alt="" /> </div> <a href="https://go.creative-biolabs.com/de-novo-antibody-sequencing-service.html"><em>De Novo</em> Antibody Sequencing Service</a> </div> <div class="col-md-4"> <div class="pagerow_pt_unit_2"> <img loading="lazy" src="/resource/images/Antibody-Based-Therapies-1.jpg" width="600" height="500" alt="" /> </div> <a href="https://go.creative-biolabs.com/antibody-based-therapies.html">Antibody-Based Therapies</a> </div> </div> </div>  <div class="tab_cont"> <div class="row pagerow_pt"> <div class="col-md-4"> <div class="pagerow_pt_unit_2"> <img loading="lazy" src="/resource/images/Magic-Therapeutic-Antibody-Discovery-Platform-Flyer-Creative-Biolabs.jpg" width="600" height="500" alt="" /> </div> <a href="/resource/pdf/com/flyers/Magic-Therapeutic-Antibody-Discovery-Platform-Flyer-Creative-Biolabs.pdf">Magic<sup>TM</sup> Therapeutic Antibody Discovery Platform</a> </div> </div> </div>  <div class="tab_cont"> <div class="row pagerow_pt"> <div class="col-md-4"> <div class="pagerow_pt_unit_2"> <img loading="lazy" src="/resource/images/Antibody-Development-Case-Study-com.jpg" width="530" height="500" alt="" /> </div> <a href="https://go.creative-biolabs.com/antibody-development-case-study.html">Antibody Development Case Study</a> </div> </div> </div>  <div class="tab_cont"> <div class="row pagerow_pt"> <div class="col-md-4"> <div class="pagerow_pt_unit"> <img loading="lazy" src="../static/img/what-is-antibody-de-novo-sequencing-1.jpg" width="600" height="500" alt="" /> </div> <a href="/what-is-antibody-de-novo-sequencing.html">What Is Antibody <em>De Novo</em> Sequencing?</a> </div> <div class="col-md-4"> <div class="pagerow_pt_unit"> <img loading="lazy" src="../static/img/what-is-protein-mass-spectrometry-technology-1.jpg" width="600" height="500" alt="" /> </div> <a href="/what-is-protein-mass-spectrometry-technology.html">What Is Protein Mass Spectrometry Technology?</a> </div> <div class="col-md-4"> <div class="pagerow_pt_unit"> <img loading="lazy" src="../static/img/hybridoma-sequencing-technology-assisting-the-r-d-and-production-1.jpg" width="600" height="500" alt="" /> </div> <a href="/hybridoma-sequencing-technology-assisting-with-the-r-d-and-production-of-monoclonal-antibodies.html">Hybridoma Sequencing Technology - 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