Lung Cancer - Cancer Science

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It typically starts in the cells lining the bronchi and parts of the lung such as the bronchioles or alveoli. Lung cancer is one of the most common types of cancer, and it is a leading cause of cancer-related deaths worldwide. The main types of lung cancer are <a href="https://cancerscience.net/about/index/small-cell-lung-cancer-(sclc)" title="small cell lung cancer (SCLC)" target="_blank">small cell lung cancer (SCLC)</a> and <a href="https://cancerscience.net/about/index/non-small-cell-lung-cancer-(nsclc)" title="non-small cell lung cancer (NSCLC)" target="_blank">non-small cell lung cancer (NSCLC)</a>.</div><div><a href="https://cancerscience.net/knowledgebase/what-are-the-risk-factors-for-lung-cancer" title="What are the Risk Factors for Lung Cancer?"><h3>What are the Risk Factors for Lung Cancer?</h3></a>There are several risk factors that can increase the likelihood of developing lung cancer. These include:</div><div> <a href="https://cancerscience.net/about/index/smoking" title="Smoking" target="_blank">Smoking</a>: The most significant risk factor, accounting for about 85% of cases.<br> <a href="https://cancerscience.net/about/index/exposure-to-radon" title="Exposure to radon" target="_blank">Exposure to radon</a> gas.<br> Exposure to asbestos, arsenic, and other <a href="https://cancerscience.net/about/index/carcinogens" title="carcinogens" target="_blank">carcinogens</a>.<br> Family history of lung cancer.<br> <a href="https://cancerscience.net/about/index/air-pollution" title="Air pollution" target="_blank">Air pollution</a>.<br> Previous radiation therapy to the chest.</div><div><a href="https://cancerscience.net/knowledgebase/what-are-the-symptoms-of-lung-cancer" title="What are the Symptoms of Lung Cancer?"><h3>What are the Symptoms of Lung Cancer?</h3></a>The symptoms of lung cancer can vary depending on the stage and type of cancer. Common symptoms include:</div><div> Persistent cough.<br> Coughing up blood or rust-colored sputum.<br> Chest pain that worsens with deep breathing, coughing, or laughing.<br> Hoarseness.<br> Weight loss and loss of appetite.<br> Shortness of breath.<br> Fatigue and weakness.</div><div><a href="https://cancerscience.net/knowledgebase/how-is-lung-cancer-diagnosed" title="How is Lung Cancer Diagnosed?"><h3>How is Lung Cancer Diagnosed?</h3></a>Diagnosis of lung cancer typically involves a combination of methods:</div><div> <a href="https://cancerscience.net/about/index/imaging-tests" title="Imaging tests" target="_blank">Imaging tests</a>: Chest X-rays, CT scans, or PET scans to identify abnormal masses.<br> <a href="https://cancerscience.net/about/index/biopsy" title="Biopsy" target="_blank">Biopsy</a>: A sample of tissue is taken from the lung and examined under a microscope.<br> <a href="https://cancerscience.net/about/index/bronchoscopy" title="Bronchoscopy" target="_blank">Bronchoscopy</a>: A procedure that allows the doctor to look inside the airways.<br> <a href="https://cancerscience.net/about/index/sputum-cytology" title="Sputum cytology" target="_blank">Sputum cytology</a>: Examining mucus coughed up from the lungs under a microscope.</div><div><a href="https://cancerscience.net/knowledgebase/what-are-the-treatment-options-for-lung-cancer" title="What are the Treatment Options for Lung Cancer?"><h3>What are the Treatment Options for Lung Cancer?</h3></a>Treatment options depend on the stage and type of lung cancer. Common treatments include:</div><div> <a href="https://cancerscience.net/about/index/surgery" title="Surgery" target="_blank">Surgery</a>: Removal of the lung tumor or a portion of the lung.<br> <a href="https://cancerscience.net/about/index/radiation-therapy" title="Radiation therapy" target="_blank">Radiation therapy</a>: Using high-energy rays to kill cancer cells.<br> <a href="https://cancerscience.net/about/index/chemotherapy" title="Chemotherapy" target="_blank">Chemotherapy</a>: Using drugs to kill cancer cells.<br> <a href="https://cancerscience.net/about/index/targeted-therapy" title="Targeted therapy" target="_blank">Targeted therapy</a>: Using drugs that target specific aspects of cancer cells.<br> <a href="https://cancerscience.net/about/index/immunotherapy" title="Immunotherapy" target="_blank">Immunotherapy</a>: Using the body's immune system to fight cancer.</div><div><a href="https://cancerscience.net/knowledgebase/what-is-the-prognosis-for-lung-cancer" title="What is the Prognosis for Lung Cancer?"><h3>What is the Prognosis for Lung Cancer?</h3></a>The prognosis for lung cancer depends on several factors, including the type and stage of cancer, the patient's overall health, and how well the cancer responds to treatment. Generally, the earlier lung cancer is caught, the better the prognosis. However, lung cancer is often diagnosed at a later stage, which can make it more difficult to treat successfully.</div><div><a href="https://cancerscience.net/knowledgebase/how-can-lung-cancer-be-prevented" title="How Can Lung Cancer be Prevented?"><h3>How Can Lung Cancer be Prevented?</h3></a>While not all cases of lung cancer can be prevented, certain measures can significantly reduce the risk:</div><div> Avoid smoking and exposure to secondhand smoke.<br> Test your home for radon and take necessary measures to reduce exposure.<br> Avoid occupational exposure to known carcinogens.<br> Maintain a healthy diet and exercise regularly.<br> Consider regular screenings if you are at high risk.</div><div><h3>Conclusion</h3>Lung cancer remains a significant public health challenge due to its high incidence and mortality rates. Understanding the risk factors, symptoms, and treatment options is crucial for early detection and effective management. Advances in <a href="https://cancerscience.net/about/index/medical-research" title="medical research" target="_blank">medical research</a> and new treatment modalities continue to improve the outlook for many patients, but prevention through lifestyle changes remains a key strategy in combating this disease.</div></div> </div> <div id="recent_papers"> <br><hr /><br><h2 class="heading1">Relevant Publications</h2> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38944844" target='_blank' title="Molecular profile of driver genes in lung adenocarcinomas of Brazilian patients who have never smoked: implications for targeted therapies.">Molecular profile of driver genes in lung adenocarcinomas of Brazilian patients who have never smoked: implications for targeted therapies.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38947080" target='_blank' title="Transferrin receptor-based circulating tumor cell enrichment provides a snapshot of the molecular landscape of solid tumors and correlates with clinical outcomes.">Transferrin receptor-based circulating tumor cell enrichment provides a snapshot of the molecular landscape of solid tumors and correlates with clinical outcomes.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38917957" target='_blank' title="Injectable nano-in situ-thermosensitive-hydrogels based on halofuginone and silver for postoperative treatment against triple-negative breast cancer.">Injectable nano-in situ-thermosensitive-hydrogels based on halofuginone and silver for postoperative treatment against triple-negative breast cancer.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38945004" target='_blank' title="BRAF mutational status is associated with survival outcomes in locally advanced resectable and metastatic NSCLC.">BRAF mutational status is associated with survival outcomes in locally advanced resectable and metastatic NSCLC.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38946828" target='_blank' title="What enlightenment has the development of lung cancer bone metastasis brought in the last 22 years.">What enlightenment has the development of lung cancer bone metastasis brought in the last 22 years.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38947380" target='_blank' title="Tanreqing injection inhibits stemness and enhances sensitivity of non-small cell lung cancer models to gefitinib through ROS/STAT3 signaling pathway.">Tanreqing injection inhibits stemness and enhances sensitivity of non-small cell lung cancer models to gefitinib through ROS/STAT3 signaling pathway.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38942660" target='_blank' title="When to Consider Invasive Lymph Node Staging in Non-Small-Cell Lung Cancer? A Novel Scoring System Utilising Metabolic Parameters in 18F-FDG PET/CT.">When to Consider Invasive Lymph Node Staging in Non-Small-Cell Lung Cancer? 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10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38946484" target='_blank' title="First-in-human clinical trial results with ABBV-184, a first-in-class T-cell Receptor/Anti-CD3 bispecific protein, in adults with Previously treated AML or NSCLC.">First-in-human clinical trial results with ABBV-184, a first-in-class T-cell Receptor/Anti-CD3 bispecific protein, in adults with Previously treated AML or NSCLC.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38946288" target='_blank' title="Lung cancer: a nationwide analysis of sex and age incidence trends from 1980 to 2022.">Lung cancer: a nationwide analysis of sex and age incidence trends from 1980 to 2022.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a 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class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38947223" target='_blank' title="A Visual Analysis of the Research Dynamics in Resistance to EGFR Inhibitors for NSCLC.">A Visual Analysis of the Research Dynamics in Resistance to EGFR Inhibitors for NSCLC.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38945312" target='_blank' title="Association of genetic variants in soy isoflavones metabolism-related genes with lung cancer risk.">Association of genetic variants in soy isoflavones metabolism-related genes with lung cancer risk.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38947418" target='_blank' title="Circulating cell-free (cf)DNA analysis: Current technologies and applications in gynecologic cancer.">Circulating cell-free (cf)DNA analysis: Current technologies and applications in gynecologic cancer.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38947555" target='_blank' title="Distinct roles and molecular mechanisms of nicotine and benzo(a)pyrene in ferroptosis of lung adenocarcinoma and lung squamous cell carcinoma.">Distinct roles and molecular mechanisms of nicotine and benzo(a)pyrene in ferroptosis of lung adenocarcinoma and lung squamous cell carcinoma.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38947743" target='_blank' title="A risk-scoring model based on endobronchial ultrasound multimodal imaging for predicting 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