Germline prediction of immune checkpoint inhibitor discontinuation for immune-related adverse events

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usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="X3iOgtNfTFHSOmfmkmOuizi1hqwEA7i98LpanRGPABdiaxzxfQoHMtxf6JgwcmBu"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="X3iOgtNfTFHSOmfmkmOuizi1hqwEA7i98LpanRGPABdiaxzxfQoHMtxf6JgwcmBu"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="X3iOgtNfTFHSOmfmkmOuizi1hqwEA7i98LpanRGPABdiaxzxfQoHMtxf6JgwcmBu"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="X3iOgtNfTFHSOmfmkmOuizi1hqwEA7i98LpanRGPABdiaxzxfQoHMtxf6JgwcmBu"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="38947092"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" 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<main class="article-details" id="article-details">   <div class="preprint-notice usa-alert usa-alert-info" role="alert" id="preprint" > <div class="usa-alert-body"> <h3 class="usa-alert-heading">This is a preprint.</h3> <div class="usa-alert-text"><b>It has not yet been peer reviewed by a journal.</b></div> <div class="usa-alert-text">The National Library of Medicine is <a href="https://pmc.ncbi.nlm.nih.gov/about/nihpreprints/">running a pilot</a> to include preprints that result from research funded by NIH in PMC and PubMed. </div> </div> </div> <header class="heading" id="heading"> <div class="full-view" id="full-view-heading"> <div class="article-citation"> <div class="article-source"> <div class="journal-actions dropdown-block"><button id="full-view-journal-trigger" class="journal-actions-trigger trigger" ref="linksrc=journal_actions_btn" title="medRxiv : the preprint server for health sciences" tabindex="0" aria-controls="full-view-journal" aria-expanded="false" 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data-ga-action="author_link" data-ga-label="Pooja Middha">Pooja Middha</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of California San Francisco, San Francisco, CA, USA." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Thummalapalli+R&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Rohit Thummalapalli">Rohit Thummalapalli</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Quandt+Z&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Zoe Quandt">Zoe Quandt</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Endocrinology and Metabolism, Department of Medicine, University of California San Francisco, San Francisco, CA, USA." href="#full-view-affiliation-3" ref="linksrc=author_aff"> 3 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Diabetes Center, University of California San Francisco, San Francisco, CA, USA." href="#full-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Balaratnam+K&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Karmugi Balaratnam">Karmugi Balaratnam</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Princess Margaret Cancer Centre, Toronto, ON, Canada." href="#full-view-affiliation-5" ref="linksrc=author_aff"> 5 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Cardenas+E&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Eduardo Cardenas">Eduardo Cardenas</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of California San Francisco, San Francisco, CA, USA." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Falcon+CJ&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Christina J Falcon">Christina J Falcon</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Fiona and Stanley Druckenmiller Center for Lung Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA." href="#full-view-affiliation-6" ref="linksrc=author_aff"> 6 </a></sup><span class="semicolon">; </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Princess+Margaret+Lung+Group%5BCorporate+Author%5D" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Princess Margaret Lung Group">Princess Margaret Lung Group</a><span class="semicolon">; </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Gubens+MA&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Matthew A Gubens">Matthew A Gubens</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Hematology and Oncology and UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, USA." href="#full-view-affiliation-7" ref="linksrc=author_aff"> 7 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Huntsman+S&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Scott Huntsman">Scott Huntsman</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of California San Francisco, San Francisco, CA, USA." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Khan+K&cauthor_id=38947092" ref="linksrc=author_name_link" 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class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Zhan+LJ&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Luna Jia Zhan">Luna Jia Zhan</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Princess Margaret Cancer Centre, Toronto, ON, Canada." href="#full-view-affiliation-5" ref="linksrc=author_aff"> 5 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Liu+G&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Geoffrey Liu">Geoffrey Liu</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Princess Margaret Cancer Centre, Temerty School of Medicine, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada." href="#full-view-affiliation-9" ref="linksrc=author_aff"> 9 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Aldrich+MC&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Melinda C Aldrich">Melinda C Aldrich</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of California San Francisco, San Francisco, CA, USA." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA." href="#full-view-affiliation-10" ref="linksrc=author_aff"> 10 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Schoenfeld+AJ&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Adam J Schoenfeld">Adam J Schoenfeld</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York." href="#full-view-affiliation-11" ref="linksrc=author_aff"> 11 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ziv+E&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Elad Ziv">Elad Ziv</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of California San Francisco, San Francisco, CA, USA." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Helen Diller Family Comprehensive Cancer Center, Center for Genes, Environment and Health and Institute for Human Genetics, University of California San Francisco, San Francisco, California." href="#full-view-affiliation-12" ref="linksrc=author_aff"> 12 </a></sup></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore data-fetch-url="/38947092/long-authors/" data-id-prefix=""> <span class="title"> Expand </span> </button> </div> <div class="extended-article-details" id="expanded-authors" aria-hidden="true"> <div class="expanded-authors" id="full-view-expanded-authors"> <div class="affiliations"> <h3 class="title"> Affiliations </h3> <ul class="item-list"> <li data-affiliation-id="full-view-affiliation-1" id="full-view-affiliation-1" ><sup class="key">1</sup> Department of Medicine, University of California San Francisco, San Francisco, CA, USA.</li> <li data-affiliation-id="full-view-affiliation-2" id="full-view-affiliation-2" ><sup class="key">2</sup> Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.</li> <li data-affiliation-id="full-view-affiliation-3" id="full-view-affiliation-3" ><sup class="key">3</sup> Division of Endocrinology and Metabolism, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.</li> <li data-affiliation-id="full-view-affiliation-4" id="full-view-affiliation-4" ><sup class="key">4</sup> Diabetes Center, University of California San Francisco, San Francisco, CA, USA.</li> <li data-affiliation-id="full-view-affiliation-5" id="full-view-affiliation-5" ><sup class="key">5</sup> Princess Margaret Cancer Centre, Toronto, ON, Canada.</li> <li data-affiliation-id="full-view-affiliation-6" id="full-view-affiliation-6" ><sup class="key">6</sup> Fiona and Stanley Druckenmiller Center for Lung Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.</li> <li data-affiliation-id="full-view-affiliation-7" id="full-view-affiliation-7" ><sup class="key">7</sup> Division of Hematology and Oncology and UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, USA.</li> <li data-affiliation-id="full-view-affiliation-8" id="full-view-affiliation-8" ><sup class="key">8</sup> Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN, USA.</li> <li data-affiliation-id="full-view-affiliation-9" id="full-view-affiliation-9" ><sup class="key">9</sup> Princess Margaret Cancer Centre, Temerty School of Medicine, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.</li> <li data-affiliation-id="full-view-affiliation-10" id="full-view-affiliation-10" ><sup class="key">10</sup> Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.</li> <li data-affiliation-id="full-view-affiliation-11" id="full-view-affiliation-11" ><sup class="key">11</sup> Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York.</li> <li data-affiliation-id="full-view-affiliation-12" id="full-view-affiliation-12" ><sup class="key">12</sup> Helen Diller Family Comprehensive Cancer Center, Center for Genes, Environment and Health and Institute for Human Genetics, University of California San Francisco, San Francisco, California.</li> </ul> </div> </div> </div> <ul class="identifiers" id="full-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">38947092</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" 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Display options </div> <div class="content"> <div class="format-container"> <span class="option-label"> Format </span> <select name="format" data-initial-value="abstract" aria-label="Display format" id="mobile-display-format"> <option value="abstract">Abstract</option> <option value="pubmed">PubMed</option> <option value="pmid">PMID</option> </select> </div> </div> </div> </div> </div> <div class="extended-article-details" id="full-article-details" aria-hidden="true"> <div class="article-citation"> <div class="article-source"> <div class="journal-actions dropdown-block"><button id="short-view-journal-trigger" class="journal-actions-trigger trigger" ref="linksrc=journal_actions_btn" title="medRxiv : the preprint server for health sciences" tabindex="0" aria-controls="short-view-journal" aria-expanded="false" aria-label="Toggle dropdown menu for journal medRxiv : the preprint server for health sciences" data-pinger-ignore> medRxiv </button><div id="short-view-journal" 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CA, USA." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Thummalapalli+R&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Rohit Thummalapalli">Rohit Thummalapalli</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Quandt+Z&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Zoe Quandt">Zoe Quandt</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Endocrinology and Metabolism, Department of Medicine, University of California San Francisco, San Francisco, CA, USA." href="#short-view-affiliation-3" ref="linksrc=author_aff"> 3 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Diabetes Center, University of California San Francisco, San Francisco, CA, USA." href="#short-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Balaratnam+K&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Karmugi Balaratnam">Karmugi Balaratnam</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Princess Margaret Cancer Centre, Toronto, ON, Canada." href="#short-view-affiliation-5" ref="linksrc=author_aff"> 5 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Cardenas+E&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Eduardo Cardenas">Eduardo Cardenas</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of California San Francisco, San Francisco, CA, USA." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Falcon+CJ&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Christina J Falcon">Christina J Falcon</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Fiona and Stanley Druckenmiller Center for Lung Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA." href="#short-view-affiliation-6" ref="linksrc=author_aff"> 6 </a></sup><span class="semicolon">; </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Princess+Margaret+Lung+Group%5BCorporate+Author%5D" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Princess Margaret Lung Group">Princess Margaret Lung Group</a><span class="semicolon">; </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Gubens+MA&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Matthew A Gubens">Matthew A Gubens</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Hematology and Oncology and UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, USA." href="#short-view-affiliation-7" ref="linksrc=author_aff"> 7 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Huntsman+S&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Scott Huntsman">Scott Huntsman</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of California San Francisco, San Francisco, CA, USA." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Khan+K&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Khaleeq Khan">Khaleeq Khan</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Princess Margaret Cancer Centre, Toronto, ON, Canada." href="#short-view-affiliation-5" ref="linksrc=author_aff"> 5 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Li+M&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Min Li">Min Li</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of California San Francisco, San Francisco, CA, USA." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Lovly+CM&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Christine M Lovly">Christine M Lovly</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN, USA." href="#short-view-affiliation-8" ref="linksrc=author_aff"> 8 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Patel+D&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Devalben Patel">Devalben Patel</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Princess Margaret Cancer Centre, Toronto, ON, Canada." href="#short-view-affiliation-5" ref="linksrc=author_aff"> 5 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Zhan+LJ&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Luna Jia Zhan">Luna Jia Zhan</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Princess Margaret Cancer Centre, Toronto, ON, Canada." href="#short-view-affiliation-5" ref="linksrc=author_aff"> 5 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Liu+G&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Geoffrey Liu">Geoffrey Liu</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Princess Margaret Cancer Centre, Temerty School of Medicine, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada." href="#short-view-affiliation-9" ref="linksrc=author_aff"> 9 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Aldrich+MC&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Melinda C Aldrich">Melinda C Aldrich</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of California San Francisco, San Francisco, CA, USA." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA." href="#short-view-affiliation-10" ref="linksrc=author_aff"> 10 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Schoenfeld+AJ&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Adam J Schoenfeld">Adam J Schoenfeld</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York." href="#short-view-affiliation-11" ref="linksrc=author_aff"> 11 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ziv+E&cauthor_id=38947092" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Elad Ziv">Elad Ziv</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of California San Francisco, San Francisco, CA, USA." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Helen Diller Family Comprehensive Cancer Center, Center for Genes, Environment and Health and Institute for Human Genetics, University of California San Francisco, San Francisco, California." href="#short-view-affiliation-12" ref="linksrc=author_aff"> 12 </a></sup></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliations </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> Department of Medicine, University of California San Francisco, San Francisco, CA, USA.</li> <li data-affiliation-id="short-view-affiliation-2" id="short-view-affiliation-2" ><sup class="key">2</sup> Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.</li> <li data-affiliation-id="short-view-affiliation-3" id="short-view-affiliation-3" ><sup class="key">3</sup> Division of Endocrinology and Metabolism, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.</li> <li data-affiliation-id="short-view-affiliation-4" id="short-view-affiliation-4" ><sup class="key">4</sup> Diabetes Center, University of California San Francisco, San Francisco, CA, USA.</li> <li data-affiliation-id="short-view-affiliation-5" id="short-view-affiliation-5" ><sup class="key">5</sup> Princess Margaret Cancer Centre, Toronto, ON, Canada.</li> <li data-affiliation-id="short-view-affiliation-6" id="short-view-affiliation-6" ><sup class="key">6</sup> Fiona and Stanley Druckenmiller Center for Lung Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.</li> <li data-affiliation-id="short-view-affiliation-7" id="short-view-affiliation-7" ><sup class="key">7</sup> Division of Hematology and Oncology and UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, USA.</li> <li data-affiliation-id="short-view-affiliation-8" id="short-view-affiliation-8" ><sup class="key">8</sup> Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN, USA.</li> <li data-affiliation-id="short-view-affiliation-9" id="short-view-affiliation-9" ><sup class="key">9</sup> Princess Margaret Cancer Centre, Temerty School of Medicine, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.</li> <li data-affiliation-id="short-view-affiliation-10" id="short-view-affiliation-10" ><sup class="key">10</sup> Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.</li> <li data-affiliation-id="short-view-affiliation-11" id="short-view-affiliation-11" ><sup class="key">11</sup> Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York.</li> <li data-affiliation-id="short-view-affiliation-12" id="short-view-affiliation-12" ><sup class="key">12</sup> Helen Diller Family Comprehensive Cancer Center, Center for Genes, Environment and Health and Institute for Human Genetics, University of California San Francisco, San Francisco, California.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">38947092</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC11213033&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11213033/" data-ga-category="full_text" data-ga-action="PMCID" > PMC11213033 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1101/2024.06.10.24308518&id_type=DOI" href="https://doi.org/10.1101/2024.06.10.24308518" data-ga-category="full_text" data-ga-action="DOI" > 10.1101/2024.06.10.24308518 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/38947092/citations/" data-citation-style="nlm" data-pubmed-format-link="/38947092/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> <strong class="sub-title"> Introduction: </strong> Immune checkpoint inhibitors (ICIs) can yield remarkable clinical responses in subsets of patients with solid tumors but can also often lead to immune-related adverse events (irAEs). Predictive features of clinically severe irAEs leading to cessation of ICIs have yet to be established. Using data from 1,327 patients with lung cancer treated with ICIs between 2009 and 2022 at four academic medical centers, we evaluated the association of a germline polygenic risk score for autoimmune disease and discontinuation of ICIs due to irAEs. </p> <p> <strong class="sub-title"> Methods: </strong> Using Cox proportional hazards model, we assessed the association between a polygenic risk score for autoimmune disease (PRS<sub>AD</sub>) and cessation of ICI therapy due to irAEs. All models were adjusted for age at diagnosis, sex, lung cancer histology, type of therapy, recruiting center, and the first 5 principal components. To further understand the differential effects of type of therapy and disease stage on the association between PRS<sub>AD</sub> and cessation of ICI due to irAEs, we conducted stratified logistic regression analysis by type of ICI therapy and disease stage. </p> <p> <strong class="sub-title"> Results: </strong> We found an association between PRS<sub>AD</sub> and ICI cessation due to irAEs (HR per SD = 1.18, 95% CI = 1.02 - 1.37, P = 0.03). This association was particularly strong in patients who had ICI cessation due to irAEs within three months of therapy initiation (HR per SD = 1.38, 95% CI = 1.08 - 1.78, P = 0.01). Individuals in the top 20th percentile of PRS<sub>AD</sub> had 7.2% ICI discontinuation for irAEs by three months, compared to 3.9% discontinuation by three months among patients in the bottom 80th percentile (log-rank P = 0.02). In addition, among patients who received combination PD-1/PD-L1 and CTLA-4 inhibitor therapy, PRS<sub>AD</sub> had an OR per SD of 1.86 (95% CI = 1.08 - 3.51, P = 0.04). </p> <p> <strong class="sub-title"> Conclusions: </strong> We demonstrate an association between a polygenic risk score for autoimmune disease and early ICI discontinuation for irAEs, particularly among patients treated with combination ICI therapy. Our results suggest that germline genetics may be used as an adjunctive tool for risk stratification around ICI clinical decision-making in solid tumor oncology. </p> </div> </div> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" data-ga-category="literature_resources" data-ga-action="disclaimer_link" data-ga-label="under_abstract">PubMed Disclaimer</a> </p> <div class="figures" id="figures"> <h2 class="title"> Figures </h2> <div class="figures-list" id="slides-container" itemscope itemtype="http://schema.org/ImageGallery"> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="0" data-label-slug="figure-1"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf58/11213033/f836235c33a0/nihpp-2024.06.10.24308518v1-f0001.jpg" itemprop="contentUrl" aria-describedby="figure-caption-0" role="button" data-image-width="750" data-image-height="417" data-image-alt="Figure 1:" data-pmc-id="PMC11213033" data-figure-id="F1"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-0" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf58/11213033/cb11626e9f6e/nihpp-2024.06.10.24308518v1-f0001.gif" alt="Figure 1:" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="750"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="417"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 1: </p> </strong> <div class="figure-caption-contents"><p> Brief overview of GeRI study… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 1: </p> </strong> <div class="figure-caption-contents"><p> Brief overview of GeRI study and analytical pipeline. The GeRI study is comprised… </p></div> </div> <figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 1: </strong> <div class="figure-caption-contents">Brief overview of GeRI study and analytical pipeline. The GeRI study is comprised of 1,328 patients with non-small cell lung cancer treated with at least one dose of immune checkpoint inhibitor (ICI) therapy. Phenotype data was manually curated from health records and each participant was provided with either a blood or saliva sample for genotyping. Genotyping was performed using Affymetrix Precision Medicine Diversity Array and imputed to 1000 genomes references panel (phase 3 v5). Association analysis between a previously published polygenic risk score for autoimmune disease (PRS<sub>AD</sub>) and ICI cessation due to immune-related adverse events (irAEs) was conducted using the Cox proportional hazards model and Fine and Gray sub-distribution hazards models (to account for competing risks). Cumulative incidence curves were obtained by genetic risk based on PRS<sub>AD</sub> percentile. Additionally, Cox proportional hazard models were performed to assess the association between PRS<sub>AD</sub> and progression-free and overall survival. Kaplan-Meier survival curves and log-rank tests were performed.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="1" data-label-slug="figure-2"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf58/11213033/38e37576c3d9/nihpp-2024.06.10.24308518v1-f0002.jpg" itemprop="contentUrl" aria-describedby="figure-caption-1" role="button" data-image-width="731" data-image-height="1000" data-image-alt="Figure 2:" data-pmc-id="PMC11213033" data-figure-id="F2"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-1" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf58/11213033/3d6645ffcad5/nihpp-2024.06.10.24308518v1-f0002.gif" alt="Figure 2:" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="731"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="1000"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 2: </p> </strong> <div class="figure-caption-contents"><p> Cumulative incidence curves for (a)… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 2: </p> </strong> <div class="figure-caption-contents"><p> Cumulative incidence curves for (a) discontinuation of immune checkpoint inhibitor (ICI) therapy due… </p></div> </div> <figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 2: </strong> <div class="figure-caption-contents">Cumulative incidence curves for (a) discontinuation of immune checkpoint inhibitor (ICI) therapy due to irAEs, (b) early discontinuation of ICI therapy due to irAEs, and (c) late discontinuation of ICI therapy due to irAEs across categories of polygenic risk score of autoimmune disease in the GeRI cohort. High genetic risk is defined as individuals in the >80<sup>th</sup> percentile (top 20th percentile), whereas low/moderate genetic risk is defined as individuals in ≤80th percentile. The p-values included on each plot are the results of a log-rank test for the difference between the curves (two-sided).</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="2" data-label-slug="figure-2"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf58/11213033/0ede57219b01/nihpp-2024.06.10.24308518v1-f0003.jpg" itemprop="contentUrl" aria-describedby="figure-caption-2" role="button" data-image-width="750" data-image-height="495" data-image-alt="Figure 2:" data-pmc-id="PMC11213033" data-figure-id="F2"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-2" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf58/11213033/3d6645ffcad5/nihpp-2024.06.10.24308518v1-f0002.gif" alt="Figure 2:" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="750"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="495"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 2: </p> </strong> <div class="figure-caption-contents"><p> Cumulative incidence curves for (a)… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 2: </p> </strong> <div class="figure-caption-contents"><p> Cumulative incidence curves for (a) discontinuation of immune checkpoint inhibitor (ICI) therapy due… </p></div> </div> <figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 2: </strong> <div class="figure-caption-contents">Cumulative incidence curves for (a) discontinuation of immune checkpoint inhibitor (ICI) therapy due to irAEs, (b) early discontinuation of ICI therapy due to irAEs, and (c) late discontinuation of ICI therapy due to irAEs across categories of polygenic risk score of autoimmune disease in the GeRI cohort. High genetic risk is defined as individuals in the >80<sup>th</sup> percentile (top 20th percentile), whereas low/moderate genetic risk is defined as individuals in ≤80th percentile. 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Germline prediction of immune checkpoint inhibitor discontinuation for immune-related adverse events - PubMed