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class="label">Followers</p><p class="data">19</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">5</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">5</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="36547469" href="https://www.academia.edu/Documents/in/Agonism"><div id="js-react-on-rails-context" 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data-dom-id="Pill-react-component-de8df632-66b7-4e8d-b677-2543f933976c"></div> <div id="Pill-react-component-de8df632-66b7-4e8d-b677-2543f933976c"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="36547469" href="https://www.academia.edu/Documents/in/Clinical_Sciences"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Clinical Sciences"]}" data-trace="false" data-dom-id="Pill-react-component-096b905a-8829-45d6-9709-d30ceca9111d"></div> <div id="Pill-react-component-096b905a-8829-45d6-9709-d30ceca9111d"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by L. Regli</h3></div><div class="js-work-strip profile--work_container" data-work-id="101486636"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/101486636/Infection_Rate_in_a_shared_two_room_Intraoperative_MRI_Concept"><img alt="Research paper thumbnail of Infection Rate in a shared two-room Intraoperative MRI Concept" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/101486636/Infection_Rate_in_a_shared_two_room_Intraoperative_MRI_Concept">Infection Rate in a shared two-room Intraoperative MRI Concept</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective: We determined the infection rate of all neurological surgeries involving a modern two-...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective: We determined the infection rate of all neurological surgeries involving a modern two-room intraoperative MRI concept. Methods: We included all 195 consecutive procedures that were performed at our institution with a high-field ioMRI, shared by Neurosurgery and Neuroradiology, between [for full text, please go to the a.m. URL]</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="101486636"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="101486636"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 101486636; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=101486636]").text(description); $(".js-view-count[data-work-id=101486636]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 101486636; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='101486636']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 101486636, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=101486636]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":101486636,"title":"Infection Rate in a shared two-room Intraoperative MRI Concept","translated_title":"","metadata":{"abstract":"Objective: We determined the infection rate of all neurological surgeries involving a modern two-room intraoperative MRI concept. 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Regli","url":"https://independent.academia.edu/LRegli"},"attachments":[],"research_interests":[{"id":515169,"name":"DDC","url":"https://www.academia.edu/Documents/in/DDC"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="101486634"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/101486634/Investigating_the_Association_of_Wallerian_Degeneration_and_Diaschisis_After_Ischemic_Stroke_With_BOLD_Cerebrovascular_Reactivity"><img alt="Research paper thumbnail of Investigating the Association of Wallerian Degeneration and Diaschisis After Ischemic Stroke With BOLD Cerebrovascular Reactivity" class="work-thumbnail" src="https://attachments.academia-assets.com/102016083/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/101486634/Investigating_the_Association_of_Wallerian_Degeneration_and_Diaschisis_After_Ischemic_Stroke_With_BOLD_Cerebrovascular_Reactivity">Investigating the Association of Wallerian Degeneration and Diaschisis After Ischemic Stroke With BOLD Cerebrovascular Reactivity</a></div><div class="wp-workCard_item"><span>Frontiers in Physiology</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">IntroductionWallerian degeneration and diaschisis are considered separate remote entities followi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">IntroductionWallerian degeneration and diaschisis are considered separate remote entities following ischemic stroke. They may, however, share common neurophysiological denominators, since they are both related to disruption of fiber tracts and brain atrophy over time. Therefore, with advanced multimodal neuroimaging, we investigate Wallerian degeneration and its association with diaschisis.MethodsIn order to determine different characteristics of Wallerian degeneration, we conducted examinations on seventeen patients with chronic unilateral ischemic stroke and persisting large vessel occlusion, conducting high-resolution anatomical magnetic resonance imaging (MRI) and blood oxygenation-level dependent cerebrovascular reactivity (BOLD-CVR) tests, as well as Diamox 15(O)–H2O–PET hemodynamic examinations. Wallerian degeneration was determined using a cerebral peduncle asymmetry index (% difference of volume of ipsilateral and contralateral cerebral peduncle) of more than two standard d...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2522523b76b08ac88defdb4b89ee8af0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102016083,"asset_id":101486634,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102016083/download_file?st=MTczMzMwNDE1NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="101486634"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="101486634"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 101486634; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=101486634]").text(description); $(".js-view-count[data-work-id=101486634]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 101486634; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='101486634']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 101486634, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2522523b76b08ac88defdb4b89ee8af0" } } $('.js-work-strip[data-work-id=101486634]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":101486634,"title":"Investigating the Association of Wallerian Degeneration and Diaschisis After Ischemic Stroke With BOLD Cerebrovascular Reactivity","translated_title":"","metadata":{"abstract":"IntroductionWallerian degeneration and diaschisis are considered separate remote entities following ischemic stroke. 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The aim of this study was to identify generalizable topological patterns with the potential to add an anatomical dimension to the classification of brain tumors.MethodsWe applied non-negative matrix factorization as an unsupervised pattern discovery strategy to the fine-grained topographic tumor profiles of 936 patients with primary and secondary brain tumors. From the anatomical features alone, this machine learning algorithm enabled the extraction of latent topological tumor patterns, termed meta-topologies. The optimal parts-based representation was automatically determined in 10,000 split-half iterations. We further characterized each meta-topology’s unique histopathologic profile and survival probability, thus linking important biological and clinical information to the underlying anatomical patternsResultsIn primary brain tumors, six meta-topologies were extracted, each det...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bb298d317e2d697d4ecc0558fb87a74d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102016080,"asset_id":101486619,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102016080/download_file?st=MTczMzMwNDE1NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="101486619"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="101486619"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 101486619; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=101486619]").text(description); $(".js-view-count[data-work-id=101486619]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 101486619; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='101486619']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 101486619, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "bb298d317e2d697d4ecc0558fb87a74d" } } $('.js-work-strip[data-work-id=101486619]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":101486619,"title":"Meta-topologies define distinct anatomical classes of brain tumors linked to histology and survival","translated_title":"","metadata":{"abstract":"BackgroundThe current WHO classification integrates histological and molecular features of brain tumors. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="101486615"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/101486615/Bevacizumab_may_improve_quality_of_life_but_not_overall_survival_in_glioblastoma_an_epidemiological_study"><img alt="Research paper thumbnail of Bevacizumab may improve quality of life, but not overall survival in glioblastoma: an epidemiological study" class="work-thumbnail" src="https://attachments.academia-assets.com/102016078/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/101486615/Bevacizumab_may_improve_quality_of_life_but_not_overall_survival_in_glioblastoma_an_epidemiological_study">Bevacizumab may improve quality of life, but not overall survival in glioblastoma: an epidemiological study</a></div><div class="wp-workCard_item"><span>Annals of Oncology</span><span>, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7f6f65b86725bef74c840d3166c1c81d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102016078,"asset_id":101486615,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102016078/download_file?st=MTczMzMwNDE1NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="101486615"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="101486615"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 101486615; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=101486615]").text(description); $(".js-view-count[data-work-id=101486615]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 101486615; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='101486615']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 101486615, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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Here, we explored the hypothesis that the approval of bevacizumab improved outcome with glioblastoma on a population level. Patients and methods: The prognostic significance of epidemiological, molecular genetic, and clinical data including treatment for glioblastoma patients diagnosed from 2010 to 2014 in the Canton of Zurich, Switzerland, was retrospectively analyzed using log-rank test and Cox proportional hazards models. Data were compared with data for the years 2005-2009. Results: In total, 310 glioblastoma patients were identified in the years 2010-2014. Median overall survival was 13.5 months for patients with known isocitrate dehydrogenase (IDH) wild-type (wt) (IDH1 R132H-non-mutant) tumors (N ¼ 248), compared with 11.3 months for IDH wt patients (P ¼ 0.761) before (2005-2009). In the IDH wt cohort, bevacizumab use at any time increased from 19% in 2005-2009 to 49% in 2010-2014. Multivariate analysis did not identify bevacizumab exposure at any time to be associated with survival. Yet, upon the second-line treatment, baseline doses of corticosteroids were reduced by more than half in 83% of patients on bevacizumab compared with 48% of the patients treated with bevacizumab-free regimens (P ¼ 0.007). Conclusion: This epidemiological study of a small, but clinically well-annotated patient cohort fails to support the assumption that the strong increase of bevacizumab use since 2010 improved survival in glioblastoma although clinical benefit associated with decreased steroid use may have been achieved.","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Annals of Oncology","grobid_abstract_attachment_id":102016078},"translated_abstract":null,"internal_url":"https://www.academia.edu/101486615/Bevacizumab_may_improve_quality_of_life_but_not_overall_survival_in_glioblastoma_an_epidemiological_study","translated_internal_url":"","created_at":"2023-05-09T01:24:42.378-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36547469,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":102016078,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102016078/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/102016078/download_file?st=MTczMzMwNDE1NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Bevacizumab_may_improve_quality_of_life.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102016078/pdf-libre.pdf?1683623562=\u0026response-content-disposition=attachment%3B+filename%3DBevacizumab_may_improve_quality_of_life.pdf\u0026Expires=1733307755\u0026Signature=b8ftEMzT~aFSlV7eBlHudbN9eyhJePF-dKXZz0dbzF0BiqtlbUfFlsQQY75~rIojE3WsA5FuetWwtUUcijBnLsFoXoPX6HEPTn0UMd4BwJYro-JsrYlo16KDxpRFTvqt95GZl31EOOVbHMS8IYt6xl~VtJ~ixVulEoW~EzwcNeCfkCm3sVYXc5YbUHh0KHqnE1Bu7zDail2C1AdtxdYXPfQhdcniiNDQEteeIxNnfKiF9NA2OMcIeQzWnkvpgLfWOJgj6MwtpDFlYBjOZgODqcf~9ZFtoxm-r-B7G-BeAw3v3BCwlKaWTW7nQaHmxB8tDt3nkvWPjksurZ7yU1aaAQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Bevacizumab_may_improve_quality_of_life_but_not_overall_survival_in_glioblastoma_an_epidemiological_study","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":36547469,"first_name":"L.","middle_initials":null,"last_name":"Regli","page_name":"LRegli","domain_name":"independent","created_at":"2015-10-19T13:27:46.944-07:00","display_name":"L. Regli","url":"https://independent.academia.edu/LRegli"},"attachments":[{"id":102016078,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102016078/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/102016078/download_file?st=MTczMzMwNDE1NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Bevacizumab_may_improve_quality_of_life.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102016078/pdf-libre.pdf?1683623562=\u0026response-content-disposition=attachment%3B+filename%3DBevacizumab_may_improve_quality_of_life.pdf\u0026Expires=1733307755\u0026Signature=b8ftEMzT~aFSlV7eBlHudbN9eyhJePF-dKXZz0dbzF0BiqtlbUfFlsQQY75~rIojE3WsA5FuetWwtUUcijBnLsFoXoPX6HEPTn0UMd4BwJYro-JsrYlo16KDxpRFTvqt95GZl31EOOVbHMS8IYt6xl~VtJ~ixVulEoW~EzwcNeCfkCm3sVYXc5YbUHh0KHqnE1Bu7zDail2C1AdtxdYXPfQhdcniiNDQEteeIxNnfKiF9NA2OMcIeQzWnkvpgLfWOJgj6MwtpDFlYBjOZgODqcf~9ZFtoxm-r-B7G-BeAw3v3BCwlKaWTW7nQaHmxB8tDt3nkvWPjksurZ7yU1aaAQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":626,"name":"Oncology","url":"https://www.academia.edu/Documents/in/Oncology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":64336,"name":"Population","url":"https://www.academia.edu/Documents/in/Population"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":190203,"name":"Cohort","url":"https://www.academia.edu/Documents/in/Cohort"},{"id":418283,"name":"Proportional hazards model","url":"https://www.academia.edu/Documents/in/Proportional_hazards_model"},{"id":555655,"name":"Bevacizumab","url":"https://www.academia.edu/Documents/in/Bevacizumab"},{"id":882996,"name":"Medicine and Health Sciences","url":"https://www.academia.edu/Documents/in/Medicine_and_Health_Sciences"}],"urls":[{"id":31293272,"url":"http://academic.oup.com/annonc/article-pdf/29/6/1431/25057125/mdy106.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="101486589"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/101486589/Predictors_of_in_Hospital_Death_Following_Aneurysmal_Subarachnoid_Hemorrhage_Analysis_of_a_Nationwide_Database_Swiss_SOS_"><img alt="Research paper thumbnail of Predictors of in-Hospital Death Following Aneurysmal Subarachnoid Hemorrhage – Analysis of a Nationwide Database (Swiss SOS)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/101486589/Predictors_of_in_Hospital_Death_Following_Aneurysmal_Subarachnoid_Hemorrhage_Analysis_of_a_Nationwide_Database_Swiss_SOS_">Predictors of in-Hospital Death Following Aneurysmal Subarachnoid Hemorrhage – Analysis of a Nationwide Database (Swiss SOS)</a></div><div class="wp-workCard_item"><span>Joint Annual Meeting 2017: Swiss Society of Neurosurgery, Swiss Society of Neuroradiology</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective: To identify predictors of in-hospital mortality in patients with aneurysmal subarachno...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective: To identify predictors of in-hospital mortality in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods: Retrospective analysis of prospective nationwide data from a multicenter registry on all aSAH cases admitted to a tertiary neurosurgical department in Switzerland between[for full text, please go to the a.m. URL]</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="101486589"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="101486589"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 101486589; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=101486589]").text(description); $(".js-view-count[data-work-id=101486589]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 101486589; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='101486589']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 101486589, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=101486589]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":101486589,"title":"Predictors of in-Hospital Death Following Aneurysmal Subarachnoid Hemorrhage – Analysis of a Nationwide Database (Swiss SOS)","translated_title":"","metadata":{"abstract":"Objective: To identify predictors of in-hospital mortality in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods: Retrospective analysis of prospective nationwide data from a multicenter registry on all aSAH cases admitted to a tertiary neurosurgical department in Switzerland between[for full text, please go to the a.m. URL]","publisher":"Georg Thieme Verlag KG","publication_date":{"day":null,"month":null,"year":2017,"errors":{}},"publication_name":"Joint Annual Meeting 2017: Swiss Society of Neurosurgery, Swiss Society of Neuroradiology"},"translated_abstract":"Objective: To identify predictors of in-hospital mortality in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods: Retrospective analysis of prospective nationwide data from a multicenter registry on all aSAH cases admitted to a tertiary neurosurgical department in Switzerland between[for full text, please go to the a.m. URL]","internal_url":"https://www.academia.edu/101486589/Predictors_of_in_Hospital_Death_Following_Aneurysmal_Subarachnoid_Hemorrhage_Analysis_of_a_Nationwide_Database_Swiss_SOS_","translated_internal_url":"","created_at":"2023-05-09T01:24:37.066-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36547469,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Predictors_of_in_Hospital_Death_Following_Aneurysmal_Subarachnoid_Hemorrhage_Analysis_of_a_Nationwide_Database_Swiss_SOS_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36547469,"first_name":"L.","middle_initials":null,"last_name":"Regli","page_name":"LRegli","domain_name":"independent","created_at":"2015-10-19T13:27:46.944-07:00","display_name":"L. 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OBJECTIVE: To test whether the surgically difficult ELANA technique can be simplified. METHODS: In 42 rabbits, with the aorta as the recipient artery and human saphenous veins as donor grafts, we made 30 conventional ELANAs with 8 microsutures, 90 ELANAs with 4 microsutures (ELANA-4s), 40 ELANAs with 2 microsutures (ELANA-2s), and 90 sutureless ELANAs (SELANAs). SELANA involved a new ring design with 2 pins. ELANA-4, ELANA-2, and SELANA were each combined with 3 different sealants (Bioglue , Tachoseal, and Tisseel ) and compared regarding application time, complications, and burst pressure. RESULTS: The conventional ELANA was constructed in a mean of 14.8 ± 2.6 minutes. All experimental anastomoses were constructed significantly faster; t...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eea35d5436f2ba406fc4f9cfc849f77b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102016062,"asset_id":101486582,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102016062/download_file?st=MTczMzMwNDE1NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="101486582"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="101486582"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 101486582; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=101486582]").text(description); $(".js-view-count[data-work-id=101486582]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 101486582; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='101486582']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 101486582, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "eea35d5436f2ba406fc4f9cfc849f77b" } } $('.js-work-strip[data-work-id=101486582]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":101486582,"title":"Experimental Simplification of the Excimer Laser–Assisted Nonocclusive Anastomosis (ELANA) Technique","translated_title":"","metadata":{"abstract":"BACKGROUND: The excimer laser-assisted nonocclusive anastomosis (ELANA) technique facilitates the construction of an end-to-side anastomosis between a donor vessel and a recipient artery without the need to temporarily occlude the recipient artery. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="101486509"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/101486509/Interhemispheric_transfer_of_visual_motion_information_after_a_posterior_callosal_lesion_a_neuropsychological_and_fMRI_study"><img alt="Research paper thumbnail of Interhemispheric transfer of visual motion information after a posterior callosal lesion: a neuropsychological and fMRI study" class="work-thumbnail" src="https://attachments.academia-assets.com/102016003/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/101486509/Interhemispheric_transfer_of_visual_motion_information_after_a_posterior_callosal_lesion_a_neuropsychological_and_fMRI_study">Interhemispheric transfer of visual motion information after a posterior callosal lesion: a neuropsychological and fMRI study</a></div><div class="wp-workCard_item"><span>Experimental Brain Research</span><span>, 2000</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ffdd060498ca8f40848d622164508d41" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102016003,"asset_id":101486509,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102016003/download_file?st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="101486509"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="101486509"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 101486509; 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On tachistoscopical left hemifield presentation, the patient was severely impaired in reading letters, words and geographical names and moderately impaired in naming pictures and colours. In contrast, interhemispheric transfer of visual motion information, tested by verbal report of the direction of short sequences of coherent dot motion presented within the left hemifield, was preserved. The pattern of cerebral activation elicited by apparent motion stimuli was studied with fMRI and compared to that of normal subjects. In normal subjects, apparent motion stimuli, as compared to darkness, activated strongly striate and extrastriate cortex. When presented to one hemifield only, the contralateral calcarine region was activated while regions on the occipital convexity, including putative area V5, were activated bilaterally. 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In the majority o...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Acute non-traumatic headache is a frequent complaint in emergency primary care. In the majority of cases, the cause is a primary headache, which can be invalidating, but should not lead to additional investigations. Secondary headaches are rare but their diagnosis is essential to avoid potentially lethal consequences. In practice, a primary headache may be difficult to differentiate from a secondary headache, especially if the initial management does not follow a systematic approach. We have adapted evidence-based guidelines to improve the diagnostic management of patients presenting acute headache. 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Regli","url":"https://independent.academia.edu/LRegli"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75323216"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/75323216/Regli_L_Brain_stem_and_cerebellar_dysfunction_after_lumbar_spinal_fluid_drainage_case_report"><img alt="Research paper thumbnail of Regli L: Brain stem and cerebellar dysfunction after lumbar spinal fluid drainage: case report" class="work-thumbnail" src="https://attachments.academia-assets.com/83137555/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/75323216/Regli_L_Brain_stem_and_cerebellar_dysfunction_after_lumbar_spinal_fluid_drainage_case_report">Regli L: Brain stem and cerebellar dysfunction after lumbar spinal fluid drainage: case report</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Lumbar spinal fluid drainage is a common procedure to reduce the risks of cerebrospinal fluid (CS...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Lumbar spinal fluid drainage is a common procedure to reduce the risks of cerebrospinal fluid (CSF) fistula after skull base fractures or various transdural neurosurgical procedures. Nevertheless, this simple and effective technique can lead to overdrainage and CSF hypovolae-mia. This report describes the case of a young patient who had a lumbar drain inserted, to avoid CSF fistula after a pterional craniotomy with opening of the frontal sinus for the clipping of a ruptured aneurysm. The drain was removed after 48 hours because of underdrainage (&lt;1 ml/h). Three days after drain removal, she developed rapid deterioration of her level of consciousness and signs of cranial nerves involvement, brain stem and cerebellar dysfunction. Intracranial pressure was low (&lt;5 cm H2O) and MRI showed brain sagging and cerebellar foramen</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8921a3ce0311c613e0aece59902ca754" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":83137555,"asset_id":75323216,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/83137555/download_file?st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75323216"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75323216"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75323216; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75323216]").text(description); $(".js-view-count[data-work-id=75323216]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75323216; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75323216']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 75323216, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8921a3ce0311c613e0aece59902ca754" } } $('.js-work-strip[data-work-id=75323216]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75323216,"title":"Regli L: Brain stem and cerebellar dysfunction after lumbar spinal fluid drainage: case report","translated_title":"","metadata":{"abstract":"Lumbar spinal fluid drainage is a common procedure to reduce the risks of cerebrospinal fluid (CSF) fistula after skull base fractures or various transdural neurosurgical procedures. 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Intracranial pressure was low (\u0026lt;5 cm H2O) and MRI showed brain sagging and cerebellar foramen","internal_url":"https://www.academia.edu/75323216/Regli_L_Brain_stem_and_cerebellar_dysfunction_after_lumbar_spinal_fluid_drainage_case_report","translated_internal_url":"","created_at":"2022-04-03T08:26:23.336-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36547469,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":83137555,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/83137555/thumbnails/1.jpg","file_name":"992.full.pdf","download_url":"https://www.academia.edu/attachments/83137555/download_file?st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Regli_L_Brain_stem_and_cerebellar_dysfun.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/83137555/992.full-libre.pdf?1648999895=\u0026response-content-disposition=attachment%3B+filename%3DRegli_L_Brain_stem_and_cerebellar_dysfun.pdf\u0026Expires=1733307756\u0026Signature=PK0uIIAdEpr5prCGTrfpMxhIw92G8xaEIC41K91QmrSLKu1y27XlFy1TSfQbfx0jy7zRKJWJ5u2AIAMRYqnc5xEu3G7aJgFV8~pCOfvB~b3w1PTaAJsXeCQbCi-kGBeBMBjIsAs0Ju41Kp7yYDBmvbpGqr9qfb0QdzwCthbYIcLWhBMzzAPfomVmqwCT-5KGg8Vfha7kl4Si6zmAOkGSO462tFR2fvsx9KxkaOoO463AWhgqxK-a~c9C5t8qzF5KXdFpgKOg5hWCAUNaatzuvSv-9rRjDe8uaWACA6A~1lKtSsjFGx016NsFRamCW84XFA611f56Q5e2TiBtW2CTeQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Regli_L_Brain_stem_and_cerebellar_dysfunction_after_lumbar_spinal_fluid_drainage_case_report","translated_slug":"","page_count":3,"language":"en","content_type":"Work","owner":{"id":36547469,"first_name":"L.","middle_initials":null,"last_name":"Regli","page_name":"LRegli","domain_name":"independent","created_at":"2015-10-19T13:27:46.944-07:00","display_name":"L. 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MATERIALS AND METHODS: Among 27 patients with symptomatic cerebrovascular vasospasm investi-gated by digital subtraction angiography (DSA), 18 underwent both cerebral PCT and MSCTA. For the remaining 9, only PCT or MSCTA could be performed. MSCTA was compared with DSA for the detection and characterization of vasospasm on 286 intracranial arterial segments. PCT maps were visually reviewed for mean transit time, relative cerebral blood flow, and relative cerebral blood volume abnormalities and were qualitatively compared with the corresponding regional vasospasm detected by DSA. RESULTS: Vasospasm was grouped into 2 categories: mild-moderate and severe. The depiction of vasospasm by MSCTA showed the best sensitivity, specificity, and accuracy at the level of the A2 and M2 arterial s...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a440e1563bd14adfba6cc176731ceeed" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":83137500,"asset_id":75323215,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/83137500/download_file?st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75323215"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75323215"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75323215; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75323215]").text(description); $(".js-view-count[data-work-id=75323215]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75323215; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75323215']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 75323215, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a440e1563bd14adfba6cc176731ceeed" } } $('.js-work-strip[data-work-id=75323215]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75323215,"title":"ORIGINAL RESEARCH CT Angiography and Perfusion CT in Cerebral","translated_title":"","metadata":{"abstract":"BACKGROUND AND PURPOSE: We investigated the association of multisection CT angiography (MSCTA) and perfusion CT (PCT) for the characterization of vasospasm secondary to aneurysmal subarachnoid hemorrhage. MATERIALS AND METHODS: Among 27 patients with symptomatic cerebrovascular vasospasm investi-gated by digital subtraction angiography (DSA), 18 underwent both cerebral PCT and MSCTA. For the remaining 9, only PCT or MSCTA could be performed. MSCTA was compared with DSA for the detection and characterization of vasospasm on 286 intracranial arterial segments. PCT maps were visually reviewed for mean transit time, relative cerebral blood flow, and relative cerebral blood volume abnormalities and were qualitatively compared with the corresponding regional vasospasm detected by DSA. RESULTS: Vasospasm was grouped into 2 categories: mild-moderate and severe. The depiction of vasospasm by MSCTA showed the best sensitivity, specificity, and accuracy at the level of the A2 and M2 arterial s...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}}},"translated_abstract":"BACKGROUND AND PURPOSE: We investigated the association of multisection CT angiography (MSCTA) and perfusion CT (PCT) for the characterization of vasospasm secondary to aneurysmal subarachnoid hemorrhage. MATERIALS AND METHODS: Among 27 patients with symptomatic cerebrovascular vasospasm investi-gated by digital subtraction angiography (DSA), 18 underwent both cerebral PCT and MSCTA. For the remaining 9, only PCT or MSCTA could be performed. MSCTA was compared with DSA for the detection and characterization of vasospasm on 286 intracranial arterial segments. PCT maps were visually reviewed for mean transit time, relative cerebral blood flow, and relative cerebral blood volume abnormalities and were qualitatively compared with the corresponding regional vasospasm detected by DSA. RESULTS: Vasospasm was grouped into 2 categories: mild-moderate and severe. 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Their usefulness[for full text, please go to the a.m. URL]</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75323214"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75323214"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75323214; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75323214]").text(description); $(".js-view-count[data-work-id=75323214]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75323214; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75323214']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 75323214, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=75323214]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75323214,"title":"Feasibility and Safety of Intraoperative BOLD MRI Cerebrovascular Reactivity to Evaluate Extracranial-to-Intracranial Bypass Efficacy","translated_title":"","metadata":{"abstract":"Objective: Blood Oxygenation-Level dependent Magnetic Resonance Imaging (BOLD MRI) sequences are commonly used to investigate cerebrovascular reactivity (CVR) and have found application in predicting stroke risk in patients affected by chronic cerebrovascular steno-occlusive diseases. 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We present the first report of a holographic neuronavigation system with patient-to-image registration and patient tracking with a reference array using an augmented reality head-mounted display (AR-HMD). Three patients undergoing an intracranial neurosurgical procedure were included in this pilot study. The relevant anatomy was first segmented in 3D and then uploaded as holographic scene in our custom neuronavigation software. Registration was performed using point-based matching using anatomical landmarks. We measured the fiducial registration error (FRE) as the outcome measure for registration accuracy. A custom-made reference array with QR codes was integrated in the neurosurgical setup and used for patient tracking after bed movement. Six registrations were performed with a mean FRE of 8.5 mm. Patient tracking was achieved with no visual difference between the registra...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cc4a08010630f2751a1a98c7a0e963a2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":83137560,"asset_id":75323213,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/83137560/download_file?st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75323213"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75323213"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75323213; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75323213]").text(description); $(".js-view-count[data-work-id=75323213]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75323213; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75323213']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 75323213, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cc4a08010630f2751a1a98c7a0e963a2" } } $('.js-work-strip[data-work-id=75323213]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75323213,"title":"Holographic patient tracking after bed movement for augmented reality neuronavigation using a head-mounted display","translated_title":"","metadata":{"abstract":"Holographic neuronavigation has several potential advantages compared to conventional neuronavigation systems. 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While some alt...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Clinical observations suggest dynamic alterations in behavior after brain surgery. While some alterations reportedly occur within days others gradually develop over several months. These alterations can be attributed to the pre-surgical impact of the diseased tissue, neuronal damage caused by the surgery, and subsequent plasticity. A key step towards a systems-level understanding of the brain-behavior relationships is to capture the dynamics of the cognitive alterations. Here, we first established in 38 healthy individuals that the day-to-day smartphone interactions can be used to inform on cognitive processing speed. Next, we analyzed the smartphone interactions in 12 patients undergoing intracranial tumor surgery, with postsurgical follow-up of up to a year. In healthy individuals, the speed of the touchscreen interactions was highly correlated to choice reaction times (R2 = 0.71) but less so to simple reaction times (R2 = 0.15) on Deary-Liewald tests. Touchscreen interactions slo...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="45afef1c42b41bec19addb9a1c15084f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":83137561,"asset_id":75323211,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/83137561/download_file?st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75323211"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75323211"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75323211; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75323211]").text(description); $(".js-view-count[data-work-id=75323211]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75323211; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75323211']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 75323211, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "45afef1c42b41bec19addb9a1c15084f" } } $('.js-work-strip[data-work-id=75323211]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75323211,"title":"Passive smartphone-based assessment of cognitive changes in neurosurgery","translated_title":"","metadata":{"abstract":"Clinical observations suggest dynamic alterations in behavior after brain surgery. 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Methods: We included all 195 consecutive procedures that were performed at our institution with a high-field ioMRI, shared by Neurosurgery and Neuroradiology, between [for full text, please go to the a.m. URL]</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="101486636"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="101486636"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 101486636; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=101486636]").text(description); $(".js-view-count[data-work-id=101486636]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 101486636; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='101486636']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 101486636, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=101486636]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":101486636,"title":"Infection Rate in a shared two-room Intraoperative MRI Concept","translated_title":"","metadata":{"abstract":"Objective: We determined the infection rate of all neurological surgeries involving a modern two-room intraoperative MRI concept. 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They may, however, share common neurophysiological denominators, since they are both related to disruption of fiber tracts and brain atrophy over time. Therefore, with advanced multimodal neuroimaging, we investigate Wallerian degeneration and its association with diaschisis.MethodsIn order to determine different characteristics of Wallerian degeneration, we conducted examinations on seventeen patients with chronic unilateral ischemic stroke and persisting large vessel occlusion, conducting high-resolution anatomical magnetic resonance imaging (MRI) and blood oxygenation-level dependent cerebrovascular reactivity (BOLD-CVR) tests, as well as Diamox 15(O)–H2O–PET hemodynamic examinations. Wallerian degeneration was determined using a cerebral peduncle asymmetry index (% difference of volume of ipsilateral and contralateral cerebral peduncle) of more than two standard d...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2522523b76b08ac88defdb4b89ee8af0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102016083,"asset_id":101486634,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102016083/download_file?st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&st=MTczMzMwNDE1NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="101486634"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="101486634"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 101486634; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=101486634]").text(description); $(".js-view-count[data-work-id=101486634]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 101486634; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='101486634']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 101486634, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2522523b76b08ac88defdb4b89ee8af0" } } $('.js-work-strip[data-work-id=101486634]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":101486634,"title":"Investigating the Association of Wallerian Degeneration and Diaschisis After Ischemic Stroke With BOLD Cerebrovascular Reactivity","translated_title":"","metadata":{"abstract":"IntroductionWallerian degeneration and diaschisis are considered separate remote entities following ischemic stroke. 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The aim of this study was to identify generalizable topological patterns with the potential to add an anatomical dimension to the classification of brain tumors.MethodsWe applied non-negative matrix factorization as an unsupervised pattern discovery strategy to the fine-grained topographic tumor profiles of 936 patients with primary and secondary brain tumors. From the anatomical features alone, this machine learning algorithm enabled the extraction of latent topological tumor patterns, termed meta-topologies. The optimal parts-based representation was automatically determined in 10,000 split-half iterations. We further characterized each meta-topology’s unique histopathologic profile and survival probability, thus linking important biological and clinical information to the underlying anatomical patternsResultsIn primary brain tumors, six meta-topologies were extracted, each det...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bb298d317e2d697d4ecc0558fb87a74d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102016080,"asset_id":101486619,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102016080/download_file?st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&st=MTczMzMwNDE1NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="101486619"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="101486619"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 101486619; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=101486619]").text(description); $(".js-view-count[data-work-id=101486619]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 101486619; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='101486619']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 101486619, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "bb298d317e2d697d4ecc0558fb87a74d" } } $('.js-work-strip[data-work-id=101486619]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":101486619,"title":"Meta-topologies define distinct anatomical classes of brain tumors linked to histology and survival","translated_title":"","metadata":{"abstract":"BackgroundThe current WHO classification integrates histological and molecular features of brain tumors. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="101486615"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/101486615/Bevacizumab_may_improve_quality_of_life_but_not_overall_survival_in_glioblastoma_an_epidemiological_study"><img alt="Research paper thumbnail of Bevacizumab may improve quality of life, but not overall survival in glioblastoma: an epidemiological study" class="work-thumbnail" src="https://attachments.academia-assets.com/102016078/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/101486615/Bevacizumab_may_improve_quality_of_life_but_not_overall_survival_in_glioblastoma_an_epidemiological_study">Bevacizumab may improve quality of life, but not overall survival in glioblastoma: an epidemiological study</a></div><div class="wp-workCard_item"><span>Annals of Oncology</span><span>, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7f6f65b86725bef74c840d3166c1c81d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102016078,"asset_id":101486615,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102016078/download_file?st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&st=MTczMzMwNDE1NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="101486615"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="101486615"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 101486615; 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Here, we explored the hypothesis that the approval of bevacizumab improved outcome with glioblastoma on a population level. Patients and methods: The prognostic significance of epidemiological, molecular genetic, and clinical data including treatment for glioblastoma patients diagnosed from 2010 to 2014 in the Canton of Zurich, Switzerland, was retrospectively analyzed using log-rank test and Cox proportional hazards models. Data were compared with data for the years 2005-2009. Results: In total, 310 glioblastoma patients were identified in the years 2010-2014. Median overall survival was 13.5 months for patients with known isocitrate dehydrogenase (IDH) wild-type (wt) (IDH1 R132H-non-mutant) tumors (N ¼ 248), compared with 11.3 months for IDH wt patients (P ¼ 0.761) before (2005-2009). In the IDH wt cohort, bevacizumab use at any time increased from 19% in 2005-2009 to 49% in 2010-2014. Multivariate analysis did not identify bevacizumab exposure at any time to be associated with survival. Yet, upon the second-line treatment, baseline doses of corticosteroids were reduced by more than half in 83% of patients on bevacizumab compared with 48% of the patients treated with bevacizumab-free regimens (P ¼ 0.007). Conclusion: This epidemiological study of a small, but clinically well-annotated patient cohort fails to support the assumption that the strong increase of bevacizumab use since 2010 improved survival in glioblastoma although clinical benefit associated with decreased steroid use may have been achieved.","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Annals of Oncology","grobid_abstract_attachment_id":102016078},"translated_abstract":null,"internal_url":"https://www.academia.edu/101486615/Bevacizumab_may_improve_quality_of_life_but_not_overall_survival_in_glioblastoma_an_epidemiological_study","translated_internal_url":"","created_at":"2023-05-09T01:24:42.378-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36547469,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":102016078,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102016078/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/102016078/download_file?st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&st=MTczMzMwNDE1NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Bevacizumab_may_improve_quality_of_life.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102016078/pdf-libre.pdf?1683623562=\u0026response-content-disposition=attachment%3B+filename%3DBevacizumab_may_improve_quality_of_life.pdf\u0026Expires=1733307755\u0026Signature=b8ftEMzT~aFSlV7eBlHudbN9eyhJePF-dKXZz0dbzF0BiqtlbUfFlsQQY75~rIojE3WsA5FuetWwtUUcijBnLsFoXoPX6HEPTn0UMd4BwJYro-JsrYlo16KDxpRFTvqt95GZl31EOOVbHMS8IYt6xl~VtJ~ixVulEoW~EzwcNeCfkCm3sVYXc5YbUHh0KHqnE1Bu7zDail2C1AdtxdYXPfQhdcniiNDQEteeIxNnfKiF9NA2OMcIeQzWnkvpgLfWOJgj6MwtpDFlYBjOZgODqcf~9ZFtoxm-r-B7G-BeAw3v3BCwlKaWTW7nQaHmxB8tDt3nkvWPjksurZ7yU1aaAQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Bevacizumab_may_improve_quality_of_life_but_not_overall_survival_in_glioblastoma_an_epidemiological_study","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":36547469,"first_name":"L.","middle_initials":null,"last_name":"Regli","page_name":"LRegli","domain_name":"independent","created_at":"2015-10-19T13:27:46.944-07:00","display_name":"L. Regli","url":"https://independent.academia.edu/LRegli"},"attachments":[{"id":102016078,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102016078/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/102016078/download_file?st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&st=MTczMzMwNDE1NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Bevacizumab_may_improve_quality_of_life.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102016078/pdf-libre.pdf?1683623562=\u0026response-content-disposition=attachment%3B+filename%3DBevacizumab_may_improve_quality_of_life.pdf\u0026Expires=1733307755\u0026Signature=b8ftEMzT~aFSlV7eBlHudbN9eyhJePF-dKXZz0dbzF0BiqtlbUfFlsQQY75~rIojE3WsA5FuetWwtUUcijBnLsFoXoPX6HEPTn0UMd4BwJYro-JsrYlo16KDxpRFTvqt95GZl31EOOVbHMS8IYt6xl~VtJ~ixVulEoW~EzwcNeCfkCm3sVYXc5YbUHh0KHqnE1Bu7zDail2C1AdtxdYXPfQhdcniiNDQEteeIxNnfKiF9NA2OMcIeQzWnkvpgLfWOJgj6MwtpDFlYBjOZgODqcf~9ZFtoxm-r-B7G-BeAw3v3BCwlKaWTW7nQaHmxB8tDt3nkvWPjksurZ7yU1aaAQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":626,"name":"Oncology","url":"https://www.academia.edu/Documents/in/Oncology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":64336,"name":"Population","url":"https://www.academia.edu/Documents/in/Population"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":190203,"name":"Cohort","url":"https://www.academia.edu/Documents/in/Cohort"},{"id":418283,"name":"Proportional hazards model","url":"https://www.academia.edu/Documents/in/Proportional_hazards_model"},{"id":555655,"name":"Bevacizumab","url":"https://www.academia.edu/Documents/in/Bevacizumab"},{"id":882996,"name":"Medicine and Health Sciences","url":"https://www.academia.edu/Documents/in/Medicine_and_Health_Sciences"}],"urls":[{"id":31293272,"url":"http://academic.oup.com/annonc/article-pdf/29/6/1431/25057125/mdy106.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="101486589"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/101486589/Predictors_of_in_Hospital_Death_Following_Aneurysmal_Subarachnoid_Hemorrhage_Analysis_of_a_Nationwide_Database_Swiss_SOS_"><img alt="Research paper thumbnail of Predictors of in-Hospital Death Following Aneurysmal Subarachnoid Hemorrhage – Analysis of a Nationwide Database (Swiss SOS)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/101486589/Predictors_of_in_Hospital_Death_Following_Aneurysmal_Subarachnoid_Hemorrhage_Analysis_of_a_Nationwide_Database_Swiss_SOS_">Predictors of in-Hospital Death Following Aneurysmal Subarachnoid Hemorrhage – Analysis of a Nationwide Database (Swiss SOS)</a></div><div class="wp-workCard_item"><span>Joint Annual Meeting 2017: Swiss Society of Neurosurgery, Swiss Society of Neuroradiology</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective: To identify predictors of in-hospital mortality in patients with aneurysmal subarachno...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective: To identify predictors of in-hospital mortality in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods: Retrospective analysis of prospective nationwide data from a multicenter registry on all aSAH cases admitted to a tertiary neurosurgical department in Switzerland between[for full text, please go to the a.m. URL]</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="101486589"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="101486589"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 101486589; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=101486589]").text(description); $(".js-view-count[data-work-id=101486589]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 101486589; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='101486589']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 101486589, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=101486589]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":101486589,"title":"Predictors of in-Hospital Death Following Aneurysmal Subarachnoid Hemorrhage – Analysis of a Nationwide Database (Swiss SOS)","translated_title":"","metadata":{"abstract":"Objective: To identify predictors of in-hospital mortality in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods: Retrospective analysis of prospective nationwide data from a multicenter registry on all aSAH cases admitted to a tertiary neurosurgical department in Switzerland between[for full text, please go to the a.m. URL]","publisher":"Georg Thieme Verlag KG","publication_date":{"day":null,"month":null,"year":2017,"errors":{}},"publication_name":"Joint Annual Meeting 2017: Swiss Society of Neurosurgery, Swiss Society of Neuroradiology"},"translated_abstract":"Objective: To identify predictors of in-hospital mortality in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods: Retrospective analysis of prospective nationwide data from a multicenter registry on all aSAH cases admitted to a tertiary neurosurgical department in Switzerland between[for full text, please go to the a.m. URL]","internal_url":"https://www.academia.edu/101486589/Predictors_of_in_Hospital_Death_Following_Aneurysmal_Subarachnoid_Hemorrhage_Analysis_of_a_Nationwide_Database_Swiss_SOS_","translated_internal_url":"","created_at":"2023-05-09T01:24:37.066-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36547469,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Predictors_of_in_Hospital_Death_Following_Aneurysmal_Subarachnoid_Hemorrhage_Analysis_of_a_Nationwide_Database_Swiss_SOS_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36547469,"first_name":"L.","middle_initials":null,"last_name":"Regli","page_name":"LRegli","domain_name":"independent","created_at":"2015-10-19T13:27:46.944-07:00","display_name":"L. Regli","url":"https://independent.academia.edu/LRegli"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":159240,"name":"Subarachnoid hemorrhage","url":"https://www.academia.edu/Documents/in/Subarachnoid_hemorrhage"},{"id":515169,"name":"DDC","url":"https://www.academia.edu/Documents/in/DDC"}],"urls":[{"id":31293258,"url":"http://www.thieme-connect.de/products/ejournals/html/10.1055/s-0037-1603834"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="101486582"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/101486582/Experimental_Simplification_of_the_Excimer_Laser_Assisted_Nonocclusive_Anastomosis_ELANA_Technique"><img alt="Research paper thumbnail of Experimental Simplification of the Excimer Laser–Assisted Nonocclusive Anastomosis (ELANA) Technique" class="work-thumbnail" src="https://attachments.academia-assets.com/102016062/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/101486582/Experimental_Simplification_of_the_Excimer_Laser_Assisted_Nonocclusive_Anastomosis_ELANA_Technique">Experimental Simplification of the Excimer Laser–Assisted Nonocclusive Anastomosis (ELANA) Technique</a></div><div class="wp-workCard_item"><span>Operative Neurosurgery</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND: The excimer laser-assisted nonocclusive anastomosis (ELANA) technique facilitates the...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND: The excimer laser-assisted nonocclusive anastomosis (ELANA) technique facilitates the construction of an end-to-side anastomosis between a donor vessel and a recipient artery without the need to temporarily occlude the recipient artery. OBJECTIVE: To test whether the surgically difficult ELANA technique can be simplified. METHODS: In 42 rabbits, with the aorta as the recipient artery and human saphenous veins as donor grafts, we made 30 conventional ELANAs with 8 microsutures, 90 ELANAs with 4 microsutures (ELANA-4s), 40 ELANAs with 2 microsutures (ELANA-2s), and 90 sutureless ELANAs (SELANAs). SELANA involved a new ring design with 2 pins. ELANA-4, ELANA-2, and SELANA were each combined with 3 different sealants (Bioglue , Tachoseal, and Tisseel ) and compared regarding application time, complications, and burst pressure. RESULTS: The conventional ELANA was constructed in a mean of 14.8 ± 2.6 minutes. All experimental anastomoses were constructed significantly faster; t...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eea35d5436f2ba406fc4f9cfc849f77b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102016062,"asset_id":101486582,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102016062/download_file?st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&st=MTczMzMwNDE1NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="101486582"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="101486582"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 101486582; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=101486582]").text(description); $(".js-view-count[data-work-id=101486582]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 101486582; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='101486582']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 101486582, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "eea35d5436f2ba406fc4f9cfc849f77b" } } $('.js-work-strip[data-work-id=101486582]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":101486582,"title":"Experimental Simplification of the Excimer Laser–Assisted Nonocclusive Anastomosis (ELANA) Technique","translated_title":"","metadata":{"abstract":"BACKGROUND: The excimer laser-assisted nonocclusive anastomosis (ELANA) technique facilitates the construction of an end-to-side anastomosis between a donor vessel and a recipient artery without the need to temporarily occlude the recipient artery. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="101486509"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/101486509/Interhemispheric_transfer_of_visual_motion_information_after_a_posterior_callosal_lesion_a_neuropsychological_and_fMRI_study"><img alt="Research paper thumbnail of Interhemispheric transfer of visual motion information after a posterior callosal lesion: a neuropsychological and fMRI study" class="work-thumbnail" src="https://attachments.academia-assets.com/102016003/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/101486509/Interhemispheric_transfer_of_visual_motion_information_after_a_posterior_callosal_lesion_a_neuropsychological_and_fMRI_study">Interhemispheric transfer of visual motion information after a posterior callosal lesion: a neuropsychological and fMRI study</a></div><div class="wp-workCard_item"><span>Experimental Brain Research</span><span>, 2000</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ffdd060498ca8f40848d622164508d41" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102016003,"asset_id":101486509,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102016003/download_file?st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="101486509"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="101486509"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 101486509; 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On tachistoscopical left hemifield presentation, the patient was severely impaired in reading letters, words and geographical names and moderately impaired in naming pictures and colours. In contrast, interhemispheric transfer of visual motion information, tested by verbal report of the direction of short sequences of coherent dot motion presented within the left hemifield, was preserved. The pattern of cerebral activation elicited by apparent motion stimuli was studied with fMRI and compared to that of normal subjects. In normal subjects, apparent motion stimuli, as compared to darkness, activated strongly striate and extrastriate cortex. When presented to one hemifield only, the contralateral calcarine region was activated while regions on the occipital convexity, including putative area V5, were activated bilaterally. A similar activation pattern was found in the patient with a posterior callosal lesion; unilateral left or right hemifield stimulation was accompanied by activation in the contralateral and ipsilateral occipital convexity. Ipsilateral hemifield representation in the extrastriate visual cortex is believed to depend on callosal input. Our observation suggests that this is not the case for visual motion representation and that other, probably parallel, pathways may mediate visual motion transfer after posterior callosotomy.","publication_date":{"day":null,"month":null,"year":2000,"errors":{}},"publication_name":"Experimental Brain Research","grobid_abstract_attachment_id":102016003},"translated_abstract":null,"internal_url":"https://www.academia.edu/101486509/Interhemispheric_transfer_of_visual_motion_information_after_a_posterior_callosal_lesion_a_neuropsychological_and_fMRI_study","translated_internal_url":"","created_at":"2023-05-09T01:23:04.874-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36547469,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":102016003,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102016003/thumbnails/1.jpg","file_name":"Clarke_2000_20Interhemispheric_20transfer_20of_20visual_20motion_20information_20after_20posterior_20callosal_20lesion__20fMRI_20study.pdf","download_url":"https://www.academia.edu/attachments/102016003/download_file?st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Interhemispheric_transfer_of_visual_moti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102016003/Clarke_2000_20Interhemispheric_20transfer_20of_20visual_20motion_20information_20after_20posterior_20callosal_20lesion__20fMRI_20study-libre.pdf?1683623571=\u0026response-content-disposition=attachment%3B+filename%3DInterhemispheric_transfer_of_visual_moti.pdf\u0026Expires=1733307756\u0026Signature=hJKpEkv043AceZxrLsn3v9FcprrVZHwsGh4xI3jsaZw2k5rsOFKTSNhdnwV4Mtyv91oJ-Ko~fS3jvNGX~J8xIo7NudmDfW-4Mdoht1hb2F4DGZoYMO90XWFFCZ73MolJQ~HDCLLyHgSQVtKe4HinoZEm2wFJHaTkCnF2YUVMcFaIIzW6gkCGoNLLEhYPdLDLBJS3odz-uFkV2qQ52z09UfmXcjpvcjE1O-Q-mjlnGBOxNZ2U8F4p-w9nTkD-Fg2Gqq6X-zmoaML5I03w2zunI3ZVt~a0r97QkBS-Z~vO5KhX5xwRNdg3CXyISN98iAhKoz~7fsNK2o3~PJEMT~U0ng__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Interhemispheric_transfer_of_visual_motion_information_after_a_posterior_callosal_lesion_a_neuropsychological_and_fMRI_study","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":36547469,"first_name":"L.","middle_initials":null,"last_name":"Regli","page_name":"LRegli","domain_name":"independent","created_at":"2015-10-19T13:27:46.944-07:00","display_name":"L. 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Regli","url":"https://independent.academia.edu/LRegli","email":"OE9mclFJSmtzbGJJM2Y4eXMzQWxlMDJueDlzWEdSSnExd1RMWmVVYURTUT0tLUVDVUU0cXJvY1k3Q1NqQVN6V0hLdHc9PQ==--c2b52c835a9e3ed4efd257ca28696f682578cb46"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="81762591"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/81762591/_Guidelines_for_the_diagnostic_evaluation_of_patients_presenting_in_emergency_for_an_acute_non_traumatic_headache_"><img alt="Research paper thumbnail of [Guidelines for the diagnostic evaluation of patients presenting in emergency for an acute non-traumatic headache]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/81762591/_Guidelines_for_the_diagnostic_evaluation_of_patients_presenting_in_emergency_for_an_acute_non_traumatic_headache_">[Guidelines for the diagnostic evaluation of patients presenting in emergency for an acute non-traumatic headache]</a></div><div class="wp-workCard_item"><span>Revue médicale suisse</span><span>, Jan 20, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Acute non-traumatic headache is a frequent complaint in emergency primary care. In the majority o...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Acute non-traumatic headache is a frequent complaint in emergency primary care. In the majority of cases, the cause is a primary headache, which can be invalidating, but should not lead to additional investigations. Secondary headaches are rare but their diagnosis is essential to avoid potentially lethal consequences. In practice, a primary headache may be difficult to differentiate from a secondary headache, especially if the initial management does not follow a systematic approach. We have adapted evidence-based guidelines to improve the diagnostic management of patients presenting acute headache. We propose an algorithm that facilitates the systematic screening of alert signs with a focused patient history and clinical exam. 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In the majority of cases, the cause is a primary headache, which can be invalidating, but should not lead to additional investigations. Secondary headaches are rare but their diagnosis is essential to avoid potentially lethal consequences. In practice, a primary headache may be difficult to differentiate from a secondary headache, especially if the initial management does not follow a systematic approach. We have adapted evidence-based guidelines to improve the diagnostic management of patients presenting acute headache. We propose an algorithm that facilitates the systematic screening of alert signs with a focused patient history and clinical exam. 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Regli","url":"https://independent.academia.edu/LRegli"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75323216"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/75323216/Regli_L_Brain_stem_and_cerebellar_dysfunction_after_lumbar_spinal_fluid_drainage_case_report"><img alt="Research paper thumbnail of Regli L: Brain stem and cerebellar dysfunction after lumbar spinal fluid drainage: case report" class="work-thumbnail" src="https://attachments.academia-assets.com/83137555/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/75323216/Regli_L_Brain_stem_and_cerebellar_dysfunction_after_lumbar_spinal_fluid_drainage_case_report">Regli L: Brain stem and cerebellar dysfunction after lumbar spinal fluid drainage: case report</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Lumbar spinal fluid drainage is a common procedure to reduce the risks of cerebrospinal fluid (CS...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Lumbar spinal fluid drainage is a common procedure to reduce the risks of cerebrospinal fluid (CSF) fistula after skull base fractures or various transdural neurosurgical procedures. Nevertheless, this simple and effective technique can lead to overdrainage and CSF hypovolae-mia. This report describes the case of a young patient who had a lumbar drain inserted, to avoid CSF fistula after a pterional craniotomy with opening of the frontal sinus for the clipping of a ruptured aneurysm. The drain was removed after 48 hours because of underdrainage (&lt;1 ml/h). Three days after drain removal, she developed rapid deterioration of her level of consciousness and signs of cranial nerves involvement, brain stem and cerebellar dysfunction. Intracranial pressure was low (&lt;5 cm H2O) and MRI showed brain sagging and cerebellar foramen</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8921a3ce0311c613e0aece59902ca754" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":83137555,"asset_id":75323216,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/83137555/download_file?st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75323216"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75323216"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75323216; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75323216]").text(description); $(".js-view-count[data-work-id=75323216]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75323216; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75323216']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 75323216, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8921a3ce0311c613e0aece59902ca754" } } $('.js-work-strip[data-work-id=75323216]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75323216,"title":"Regli L: Brain stem and cerebellar dysfunction after lumbar spinal fluid drainage: case report","translated_title":"","metadata":{"abstract":"Lumbar spinal fluid drainage is a common procedure to reduce the risks of cerebrospinal fluid (CSF) fistula after skull base fractures or various transdural neurosurgical procedures. Nevertheless, this simple and effective technique can lead to overdrainage and CSF hypovolae-mia. This report describes the case of a young patient who had a lumbar drain inserted, to avoid CSF fistula after a pterional craniotomy with opening of the frontal sinus for the clipping of a ruptured aneurysm. The drain was removed after 48 hours because of underdrainage (\u0026lt;1 ml/h). Three days after drain removal, she developed rapid deterioration of her level of consciousness and signs of cranial nerves involvement, brain stem and cerebellar dysfunction. Intracranial pressure was low (\u0026lt;5 cm H2O) and MRI showed brain sagging and cerebellar foramen","publication_date":{"day":null,"month":null,"year":2016,"errors":{}}},"translated_abstract":"Lumbar spinal fluid drainage is a common procedure to reduce the risks of cerebrospinal fluid (CSF) fistula after skull base fractures or various transdural neurosurgical procedures. 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Intracranial pressure was low (\u0026lt;5 cm H2O) and MRI showed brain sagging and cerebellar foramen","internal_url":"https://www.academia.edu/75323216/Regli_L_Brain_stem_and_cerebellar_dysfunction_after_lumbar_spinal_fluid_drainage_case_report","translated_internal_url":"","created_at":"2022-04-03T08:26:23.336-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36547469,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":83137555,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/83137555/thumbnails/1.jpg","file_name":"992.full.pdf","download_url":"https://www.academia.edu/attachments/83137555/download_file?st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Regli_L_Brain_stem_and_cerebellar_dysfun.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/83137555/992.full-libre.pdf?1648999895=\u0026response-content-disposition=attachment%3B+filename%3DRegli_L_Brain_stem_and_cerebellar_dysfun.pdf\u0026Expires=1733307756\u0026Signature=PK0uIIAdEpr5prCGTrfpMxhIw92G8xaEIC41K91QmrSLKu1y27XlFy1TSfQbfx0jy7zRKJWJ5u2AIAMRYqnc5xEu3G7aJgFV8~pCOfvB~b3w1PTaAJsXeCQbCi-kGBeBMBjIsAs0Ju41Kp7yYDBmvbpGqr9qfb0QdzwCthbYIcLWhBMzzAPfomVmqwCT-5KGg8Vfha7kl4Si6zmAOkGSO462tFR2fvsx9KxkaOoO463AWhgqxK-a~c9C5t8qzF5KXdFpgKOg5hWCAUNaatzuvSv-9rRjDe8uaWACA6A~1lKtSsjFGx016NsFRamCW84XFA611f56Q5e2TiBtW2CTeQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Regli_L_Brain_stem_and_cerebellar_dysfunction_after_lumbar_spinal_fluid_drainage_case_report","translated_slug":"","page_count":3,"language":"en","content_type":"Work","owner":{"id":36547469,"first_name":"L.","middle_initials":null,"last_name":"Regli","page_name":"LRegli","domain_name":"independent","created_at":"2015-10-19T13:27:46.944-07:00","display_name":"L. 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MATERIALS AND METHODS: Among 27 patients with symptomatic cerebrovascular vasospasm investi-gated by digital subtraction angiography (DSA), 18 underwent both cerebral PCT and MSCTA. For the remaining 9, only PCT or MSCTA could be performed. MSCTA was compared with DSA for the detection and characterization of vasospasm on 286 intracranial arterial segments. PCT maps were visually reviewed for mean transit time, relative cerebral blood flow, and relative cerebral blood volume abnormalities and were qualitatively compared with the corresponding regional vasospasm detected by DSA. RESULTS: Vasospasm was grouped into 2 categories: mild-moderate and severe. The depiction of vasospasm by MSCTA showed the best sensitivity, specificity, and accuracy at the level of the A2 and M2 arterial s...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a440e1563bd14adfba6cc176731ceeed" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":83137500,"asset_id":75323215,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/83137500/download_file?st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75323215"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75323215"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75323215; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75323215]").text(description); $(".js-view-count[data-work-id=75323215]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75323215; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75323215']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 75323215, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a440e1563bd14adfba6cc176731ceeed" } } $('.js-work-strip[data-work-id=75323215]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75323215,"title":"ORIGINAL RESEARCH CT Angiography and Perfusion CT in Cerebral","translated_title":"","metadata":{"abstract":"BACKGROUND AND PURPOSE: We investigated the association of multisection CT angiography (MSCTA) and perfusion CT (PCT) for the characterization of vasospasm secondary to aneurysmal subarachnoid hemorrhage. MATERIALS AND METHODS: Among 27 patients with symptomatic cerebrovascular vasospasm investi-gated by digital subtraction angiography (DSA), 18 underwent both cerebral PCT and MSCTA. For the remaining 9, only PCT or MSCTA could be performed. MSCTA was compared with DSA for the detection and characterization of vasospasm on 286 intracranial arterial segments. PCT maps were visually reviewed for mean transit time, relative cerebral blood flow, and relative cerebral blood volume abnormalities and were qualitatively compared with the corresponding regional vasospasm detected by DSA. RESULTS: Vasospasm was grouped into 2 categories: mild-moderate and severe. The depiction of vasospasm by MSCTA showed the best sensitivity, specificity, and accuracy at the level of the A2 and M2 arterial s...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}}},"translated_abstract":"BACKGROUND AND PURPOSE: We investigated the association of multisection CT angiography (MSCTA) and perfusion CT (PCT) for the characterization of vasospasm secondary to aneurysmal subarachnoid hemorrhage. MATERIALS AND METHODS: Among 27 patients with symptomatic cerebrovascular vasospasm investi-gated by digital subtraction angiography (DSA), 18 underwent both cerebral PCT and MSCTA. For the remaining 9, only PCT or MSCTA could be performed. MSCTA was compared with DSA for the detection and characterization of vasospasm on 286 intracranial arterial segments. PCT maps were visually reviewed for mean transit time, relative cerebral blood flow, and relative cerebral blood volume abnormalities and were qualitatively compared with the corresponding regional vasospasm detected by DSA. RESULTS: Vasospasm was grouped into 2 categories: mild-moderate and severe. 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Their usefulness[for full text, please go to the a.m. URL]</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75323214"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75323214"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75323214; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75323214]").text(description); $(".js-view-count[data-work-id=75323214]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75323214; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75323214']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 75323214, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=75323214]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75323214,"title":"Feasibility and Safety of Intraoperative BOLD MRI Cerebrovascular Reactivity to Evaluate Extracranial-to-Intracranial Bypass Efficacy","translated_title":"","metadata":{"abstract":"Objective: Blood Oxygenation-Level dependent Magnetic Resonance Imaging (BOLD MRI) sequences are commonly used to investigate cerebrovascular reactivity (CVR) and have found application in predicting stroke risk in patients affected by chronic cerebrovascular steno-occlusive diseases. 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We present the first report of a holographic neuronavigation system with patient-to-image registration and patient tracking with a reference array using an augmented reality head-mounted display (AR-HMD). Three patients undergoing an intracranial neurosurgical procedure were included in this pilot study. The relevant anatomy was first segmented in 3D and then uploaded as holographic scene in our custom neuronavigation software. Registration was performed using point-based matching using anatomical landmarks. We measured the fiducial registration error (FRE) as the outcome measure for registration accuracy. A custom-made reference array with QR codes was integrated in the neurosurgical setup and used for patient tracking after bed movement. Six registrations were performed with a mean FRE of 8.5 mm. Patient tracking was achieved with no visual difference between the registra...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cc4a08010630f2751a1a98c7a0e963a2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":83137560,"asset_id":75323213,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/83137560/download_file?st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&st=MTczMzMwNDE1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75323213"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75323213"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75323213; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75323213]").text(description); $(".js-view-count[data-work-id=75323213]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75323213; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75323213']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 75323213, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cc4a08010630f2751a1a98c7a0e963a2" } } $('.js-work-strip[data-work-id=75323213]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75323213,"title":"Holographic patient tracking after bed movement for augmented reality neuronavigation using a head-mounted display","translated_title":"","metadata":{"abstract":"Holographic neuronavigation has several potential advantages compared to conventional neuronavigation systems. 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While some alt...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Clinical observations suggest dynamic alterations in behavior after brain surgery. While some alterations reportedly occur within days others gradually develop over several months. These alterations can be attributed to the pre-surgical impact of the diseased tissue, neuronal damage caused by the surgery, and subsequent plasticity. A key step towards a systems-level understanding of the brain-behavior relationships is to capture the dynamics of the cognitive alterations. Here, we first established in 38 healthy individuals that the day-to-day smartphone interactions can be used to inform on cognitive processing speed. Next, we analyzed the smartphone interactions in 12 patients undergoing intracranial tumor surgery, with postsurgical follow-up of up to a year. In healthy individuals, the speed of the touchscreen interactions was highly correlated to choice reaction times (R2 = 0.71) but less so to simple reaction times (R2 = 0.15) on Deary-Liewald tests. 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