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overflow: hidden; text-overflow: ellipsis; -webkit-line-clamp: 3; -webkit-box-orient: vertical; }</style><div class="col-xs-12 clearfix"><div class="u-floatLeft"><h1 class="PageHeader-title u-m0x u-fs30">Epilepsy</h1><div class="u-tcGrayDark">18,830 Followers</div><div class="u-tcGrayDark u-mt2x">Recent papers in <b>Epilepsy</b></div></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline u-displayFlex"><li class="active"><a href="https://www.academia.edu/Documents/in/Epilepsy">Top Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Epilepsy/MostCited">Most Cited Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Epilepsy/MostDownloaded">Most Downloaded Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Epilepsy/MostRecent">Newest Papers</a></li><li><a class="" href="https://www.academia.edu/People/Epilepsy">People</a></li></ul></div><style type="text/css">ul.nav{flex-direction:row}@media(max-width: 567px){ul.nav{flex-direction:column}.TabbedNavigation li{max-width:100%}.TabbedNavigation li.active{background-color:var(--background-grey, #dddde2)}.TabbedNavigation li.active:before,.TabbedNavigation li.active:after{display:none}}</style></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_30306681" data-work_id="30306681" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/30306681/A_Possible_Role_of_the_Thalamus_in_Some_Cases_of_Sudden_Unexpected_Death_in_Epilepsy">A Possible Role of the Thalamus in Some Cases of Sudden Unexpected Death in Epilepsy</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/30306681" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d0b4a77ac734de727e143a83f71acb08" rel="nofollow" data-download="{"attachment_id":50764315,"asset_id":30306681,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/50764315/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="57682210" href="https://unifesp.academia.edu/RicardoMarioArida">Ricardo Mario Arida</a><script data-card-contents-for-user="57682210" type="text/json">{"id":57682210,"first_name":"Ricardo Mario","last_name":"Arida","domain_name":"unifesp","page_name":"RicardoMarioArida","display_name":"Ricardo Mario Arida","profile_url":"https://unifesp.academia.edu/RicardoMarioArida?f_ri=7648","photo":"https://0.academia-photos.com/57682210/177534927/167601981/s65_ricardo_mario.arida.jpeg"}</script></span></span></li><li class="js-paper-rank-work_30306681 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="30306681"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 30306681, container: ".js-paper-rank-work_30306681", }); 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It has been suggested that the contradictory findings in this area reflect the use of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_24080260" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Dissociation is regarded as a possible psychological mechanism in nonepileptic seizures (NES), although existing evidence for this is equivocal. It has been suggested that the contradictory findings in this area reflect the use of measures that conflate qualitatively distinct types of dissociation, and provide inadequate coverage of the aspects of dissociation most closely related to NES. The study described here addressed this shortcoming by measuring the occurrence of two different types of dissociation, ''detachment" (measured using the Cambridge Depersonalisation Scale) and ''compartmentalization" (measured using the Somatoform Dissociation Questionnaire), in patients with NES (n = 32) and epilepsy controls (n = 37). As predicted, patients with NES scored significantly higher on the measure of compartmentalization only; contrary to prediction, however, this difference was no longer significant when anxiety and depression were controlled for. The conceptual and methodological implications of the study are discussed.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24080260" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="01217328177e74441fbc85a9c77cd255" rel="nofollow" data-download="{"attachment_id":44449099,"asset_id":24080260,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44449099/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="37744175" href="https://liverpool.academia.edu/GBaker">Gus Baker</a><script data-card-contents-for-user="37744175" type="text/json">{"id":37744175,"first_name":"Gus","last_name":"Baker","domain_name":"liverpool","page_name":"GBaker","display_name":"Gus Baker","profile_url":"https://liverpool.academia.edu/GBaker?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24080260 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24080260"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24080260, container: ".js-paper-rank-work_24080260", }); 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It has been suggested that the contradictory findings in this area reflect the use of measures that conflate qualitatively distinct types of dissociation, and provide inadequate coverage of the aspects of dissociation most closely related to NES. The study described here addressed this shortcoming by measuring the occurrence of two different types of dissociation, ''detachment\" (measured using the Cambridge Depersonalisation Scale) and ''compartmentalization\" (measured using the Somatoform Dissociation Questionnaire), in patients with NES (n = 32) and epilepsy controls (n = 37). As predicted, patients with NES scored significantly higher on the measure of compartmentalization only; contrary to prediction, however, this difference was no longer significant when anxiety and depression were controlled for. The conceptual and methodological implications of the study are discussed.","downloadable_attachments":[{"id":44449099,"asset_id":24080260,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":37744175,"first_name":"Gus","last_name":"Baker","domain_name":"liverpool","page_name":"GBaker","display_name":"Gus Baker","profile_url":"https://liverpool.academia.edu/GBaker?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2599,"name":"Psychometrics","url":"https://www.academia.edu/Documents/in/Psychometrics?f_ri=7648","nofollow":true},{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":38676,"name":"Anxiety","url":"https://www.academia.edu/Documents/in/Anxiety?f_ri=7648","nofollow":true},{"id":51757,"name":"Dissociation","url":"https://www.academia.edu/Documents/in/Dissociation?f_ri=7648"},{"id":73785,"name":"Personality Assessment Inventory","url":"https://www.academia.edu/Documents/in/Personality_Assessment_Inventory?f_ri=7648"},{"id":154385,"name":"Dissociative disorders","url":"https://www.academia.edu/Documents/in/Dissociative_disorders?f_ri=7648"},{"id":162159,"name":"Differential Diagnosis","url":"https://www.academia.edu/Documents/in/Differential_Diagnosis?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":593745,"name":"Compartmentalization","url":"https://www.academia.edu/Documents/in/Compartmentalization?f_ri=7648"},{"id":623821,"name":"ANXIETY","url":"https://www.academia.edu/Documents/in/ANXIETY-1?f_ri=7648"},{"id":651604,"name":"Seizures","url":"https://www.academia.edu/Documents/in/Seizures?f_ri=7648"},{"id":1299040,"name":"Depersonalization","url":"https://www.academia.edu/Documents/in/Depersonalization?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13844062" data-work_id="13844062" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13844062/Epidemiology_of_the_epilepsies">Epidemiology of the epilepsies</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13844062" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="82bf6387c5b9cce31a2bb5a0459831bc" rel="nofollow" data-download="{"attachment_id":44888327,"asset_id":13844062,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44888327/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32936371" href="https://ucl.academia.edu/JosemirSander">Ley Sander</a><script data-card-contents-for-user="32936371" type="text/json">{"id":32936371,"first_name":"Ley","last_name":"Sander","domain_name":"ucl","page_name":"JosemirSander","display_name":"Ley Sander","profile_url":"https://ucl.academia.edu/JosemirSander?f_ri=7648","photo":"https://0.academia-photos.com/32936371/13032276/14375798/s65_ley.sander.png"}</script></span></span></li><li class="js-paper-rank-work_13844062 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13844062"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13844062, container: ".js-paper-rank-work_13844062", }); 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$(".js-view-count[data-work-id=13844062]").text(description); $(".js-view-count-work_13844062").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13844062").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13844062"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">6</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="4990" rel="nofollow" href="https://www.academia.edu/Documents/in/Global_Health">Global Health</a>, <script data-card-contents-for-ri="4990" type="text/json">{"id":4990,"name":"Global Health","url":"https://www.academia.edu/Documents/in/Global_Health?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="174502" rel="nofollow" href="https://www.academia.edu/Documents/in/Incidence">Incidence</a>, <script data-card-contents-for-ri="174502" type="text/json">{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="192721" rel="nofollow" href="https://www.academia.edu/Documents/in/Risk_factors">Risk factors</a><script data-card-contents-for-ri="192721" type="text/json">{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13844062]'), work: {"id":13844062,"title":"Epidemiology of the epilepsies","created_at":"2015-07-09T09:47:47.730-07:00","url":"https://www.academia.edu/13844062/Epidemiology_of_the_epilepsies?f_ri=7648","dom_id":"work_13844062","summary":null,"downloadable_attachments":[{"id":44888327,"asset_id":13844062,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32936371,"first_name":"Ley","last_name":"Sander","domain_name":"ucl","page_name":"JosemirSander","display_name":"Ley Sander","profile_url":"https://ucl.academia.edu/JosemirSander?f_ri=7648","photo":"https://0.academia-photos.com/32936371/13032276/14375798/s65_ley.sander.png"}],"research_interests":[{"id":4990,"name":"Global Health","url":"https://www.academia.edu/Documents/in/Global_Health?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=7648","nofollow":true},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=7648","nofollow":true},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=7648"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_12361859" data-work_id="12361859" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/12361859/Epilepsy_in_the_Renaissance_A_survey_of_remedies_from_16th_and_17th_century_German_herbals">Epilepsy in the Renaissance: A survey of remedies from 16th and 17th century German herbals</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Ethnopharmacological relevance: Before modern anticonvulsive drugs were developed people in central Europe used herbal remedies to treat epilepsy. Hundreds of different plants for this indication can be found in German herbals of the 16th... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_12361859" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Ethnopharmacological relevance: Before modern anticonvulsive drugs were developed people in central Europe used herbal remedies to treat epilepsy. Hundreds of different plants for this indication can be found in German herbals of the 16th and 17th centuries. Here we compile these plants and discuss their use from a pharmacological perspective. Materials and methods: Nine of the most important European herbals of the 16th and 17th century including Bock (1577), Fuchs (1543), Mattioli (1590), Lonicerus (1660, 1770), Brunfels (1532), Zwinger (1696), and Tabernaemontanus (1591, 1678) were searched for terms related to epilepsy, and plants and recipes described for its treatment were documented. We then searched scientific literature for pharmacological evidence of their effectiveness. Additionally the overlapping of these remedies with those in De Materia Medica by the Greek physician Dioscorides was studied. Results: Two hundred twenty one plants were identified in the herbals to be used in the context of epilepsy. In vitro and/or in vivo pharmacological data somehow related to the indication epilepsy was found for less than 5% of these plants. Less than 7% of epilepsy remedies are in common with De Materia Medica. Conclusions: Numerous plants were used to treat epilepsy in the 16th and 17th centuries. However, few of these plants have been investigated with respect to pharmacological activity on epilepsy related targets.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/12361859" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0153efbd36362d3c4be2e99ef24dea36" rel="nofollow" data-download="{"attachment_id":46222806,"asset_id":12361859,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46222806/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="31072728" href="https://independent.academia.edu/HamburgerMatthias">Matthias Hamburger</a><script data-card-contents-for-user="31072728" type="text/json">{"id":31072728,"first_name":"Matthias","last_name":"Hamburger","domain_name":"independent","page_name":"HamburgerMatthias","display_name":"Matthias Hamburger","profile_url":"https://independent.academia.edu/HamburgerMatthias?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_12361859 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="12361859"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 12361859, container: ".js-paper-rank-work_12361859", }); 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$(".js-view-count[data-work-id=12361859]").text(description); $(".js-view-count-work_12361859").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_12361859").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="12361859"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="130" rel="nofollow" href="https://www.academia.edu/Documents/in/Ancient_History">Ancient History</a>, <script data-card-contents-for-ri="130" type="text/json">{"id":130,"name":"Ancient History","url":"https://www.academia.edu/Documents/in/Ancient_History?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3612" rel="nofollow" href="https://www.academia.edu/Documents/in/Renaissance">Renaissance</a>, <script data-card-contents-for-ri="3612" type="text/json">{"id":3612,"name":"Renaissance","url":"https://www.academia.edu/Documents/in/Renaissance?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4083" rel="nofollow" href="https://www.academia.edu/Documents/in/Complementary_and_Alternative_Medicine">Complementary and Alternative Medicine</a>, <script data-card-contents-for-ri="4083" type="text/json">{"id":4083,"name":"Complementary and Alternative Medicine","url":"https://www.academia.edu/Documents/in/Complementary_and_Alternative_Medicine?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4086" rel="nofollow" href="https://www.academia.edu/Documents/in/Traditional_Medicine">Traditional Medicine</a><script data-card-contents-for-ri="4086" type="text/json">{"id":4086,"name":"Traditional Medicine","url":"https://www.academia.edu/Documents/in/Traditional_Medicine?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=12361859]'), work: {"id":12361859,"title":"Epilepsy in the Renaissance: A survey of remedies from 16th and 17th century German herbals","created_at":"2015-05-13T00:12:56.089-07:00","url":"https://www.academia.edu/12361859/Epilepsy_in_the_Renaissance_A_survey_of_remedies_from_16th_and_17th_century_German_herbals?f_ri=7648","dom_id":"work_12361859","summary":"Ethnopharmacological relevance: Before modern anticonvulsive drugs were developed people in central Europe used herbal remedies to treat epilepsy. Hundreds of different plants for this indication can be found in German herbals of the 16th and 17th centuries. Here we compile these plants and discuss their use from a pharmacological perspective. Materials and methods: Nine of the most important European herbals of the 16th and 17th century including Bock (1577), Fuchs (1543), Mattioli (1590), Lonicerus (1660, 1770), Brunfels (1532), Zwinger (1696), and Tabernaemontanus (1591, 1678) were searched for terms related to epilepsy, and plants and recipes described for its treatment were documented. We then searched scientific literature for pharmacological evidence of their effectiveness. Additionally the overlapping of these remedies with those in De Materia Medica by the Greek physician Dioscorides was studied. Results: Two hundred twenty one plants were identified in the herbals to be used in the context of epilepsy. In vitro and/or in vivo pharmacological data somehow related to the indication epilepsy was found for less than 5% of these plants. Less than 7% of epilepsy remedies are in common with De Materia Medica. Conclusions: Numerous plants were used to treat epilepsy in the 16th and 17th centuries. However, few of these plants have been investigated with respect to pharmacological activity on epilepsy related targets.","downloadable_attachments":[{"id":46222806,"asset_id":12361859,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":31072728,"first_name":"Matthias","last_name":"Hamburger","domain_name":"independent","page_name":"HamburgerMatthias","display_name":"Matthias Hamburger","profile_url":"https://independent.academia.edu/HamburgerMatthias?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":130,"name":"Ancient History","url":"https://www.academia.edu/Documents/in/Ancient_History?f_ri=7648","nofollow":true},{"id":3612,"name":"Renaissance","url":"https://www.academia.edu/Documents/in/Renaissance?f_ri=7648","nofollow":true},{"id":4083,"name":"Complementary and Alternative Medicine","url":"https://www.academia.edu/Documents/in/Complementary_and_Alternative_Medicine?f_ri=7648","nofollow":true},{"id":4086,"name":"Traditional Medicine","url":"https://www.academia.edu/Documents/in/Traditional_Medicine?f_ri=7648","nofollow":true},{"id":5541,"name":"Plant Biology","url":"https://www.academia.edu/Documents/in/Plant_Biology?f_ri=7648"},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648"},{"id":14032,"name":"Ethnopharmacology","url":"https://www.academia.edu/Documents/in/Ethnopharmacology?f_ri=7648"},{"id":15019,"name":"Medicinal Plants","url":"https://www.academia.edu/Documents/in/Medicinal_Plants?f_ri=7648"},{"id":29916,"name":"PET","url":"https://www.academia.edu/Documents/in/PET?f_ri=7648"},{"id":48044,"name":"Greece","url":"https://www.academia.edu/Documents/in/Greece?f_ri=7648"},{"id":50576,"name":"Germany","url":"https://www.academia.edu/Documents/in/Germany?f_ri=7648"},{"id":52027,"name":"Phytotherapy","url":"https://www.academia.edu/Documents/in/Phytotherapy?f_ri=7648"},{"id":251027,"name":"NMDA","url":"https://www.academia.edu/Documents/in/NMDA?f_ri=7648"},{"id":300599,"name":"AMPA","url":"https://www.academia.edu/Documents/in/AMPA?f_ri=7648"},{"id":579863,"name":"Materia Medica","url":"https://www.academia.edu/Documents/in/Materia_Medica?f_ri=7648"},{"id":669339,"name":"Mes","url":"https://www.academia.edu/Documents/in/Mes?f_ri=7648"},{"id":1002882,"name":"Pharmacological Activity","url":"https://www.academia.edu/Documents/in/Pharmacological_Activity?f_ri=7648"},{"id":1445597,"name":"MRT","url":"https://www.academia.edu/Documents/in/MRT?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24964395" data-work_id="24964395" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24964395/The_Wellness_Revolution_Hemp_and_Cannabinoids_Introduction_281_Words">The Wellness Revolution – Hemp and Cannabinoids Introduction – 281 Words</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Cannabinoids, especially Cannabidiol from Industrial Hemp is becoming known as a medicine for symptoms including Cancer, Epilepsy, PTSD, Alzeheimers, Pain and Crohn's disease. Why?</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24964395" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f08ed99a37a1aab0064f9ea530485a21" rel="nofollow" data-download="{"attachment_id":45296129,"asset_id":24964395,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45296129/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="40284297" href="https://sydney.academia.edu/PaulBenhaim">Paul Benhaim</a><script data-card-contents-for-user="40284297" type="text/json">{"id":40284297,"first_name":"Paul","last_name":"Benhaim","domain_name":"sydney","page_name":"PaulBenhaim","display_name":"Paul Benhaim","profile_url":"https://sydney.academia.edu/PaulBenhaim?f_ri=7648","photo":"https://0.academia-photos.com/40284297/12676369/14100570/s65_paul.benhaim.jpg_oh_2c4f33782f4df225dc598d8374a091f0_oe_5799f790"}</script></span></span></li><li class="js-paper-rank-work_24964395 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24964395"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24964395, container: ".js-paper-rank-work_24964395", }); 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$(".js-view-count[data-work-id=24964395]").text(description); $(".js-view-count-work_24964395").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24964395").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24964395"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">24</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="3718" rel="nofollow" href="https://www.academia.edu/Documents/in/Posttraumatic_Stress_Disorder_PTSD_">Posttraumatic Stress Disorder (PTSD)</a>, <script data-card-contents-for-ri="3718" type="text/json">{"id":3718,"name":"Posttraumatic Stress Disorder (PTSD)","url":"https://www.academia.edu/Documents/in/Posttraumatic_Stress_Disorder_PTSD_?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4479" rel="nofollow" href="https://www.academia.edu/Documents/in/Chronic_Pain">Chronic Pain</a>, <script data-card-contents-for-ri="4479" type="text/json">{"id":4479,"name":"Chronic Pain","url":"https://www.academia.edu/Documents/in/Chronic_Pain?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6021" rel="nofollow" href="https://www.academia.edu/Documents/in/Cancer">Cancer</a>, <script data-card-contents-for-ri="6021" type="text/json">{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a><script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24964395]'), work: {"id":24964395,"title":"The Wellness Revolution – Hemp and Cannabinoids Introduction – 281 Words","created_at":"2016-05-02T21:07:54.521-07:00","url":"https://www.academia.edu/24964395/The_Wellness_Revolution_Hemp_and_Cannabinoids_Introduction_281_Words?f_ri=7648","dom_id":"work_24964395","summary":"Cannabinoids, especially Cannabidiol from Industrial Hemp is becoming known as a medicine for symptoms including Cancer, Epilepsy, PTSD, Alzeheimers, Pain and Crohn's disease. 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u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21330187" data-work_id="21330187" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21330187/Conditions_and_circumstances_predisposing_to_death_from_positional_asphyxia_in_adults">Conditions and circumstances predisposing to death from positional asphyxia in adults</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Positional asphyxia refers to a situation where there is compromise of respiration because of splinting of the chest and/or diaphragm preventing normal respiratory excursion, or occlusion of the upper airway due to abnormal positioning of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21330187" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Positional asphyxia refers to a situation where there is compromise of respiration because of splinting of the chest and/or diaphragm preventing normal respiratory excursion, or occlusion of the upper airway due to abnormal positioning of the body. Examination of autopsy files at Forensic Science SA revealed instances where positional asphyxia resulted from inadvertent positioning that compromised respiration due to intoxication, multiple sclerosis, epilepsy, Parkinson disease, Steele-Richardson-Olszewski syndrome, Lafora disease and quadriplegia. While the manner of death was accidental in most cases, in one instance suicide could not be ruled out. We would not exclude the possibility of individuals with significant cardiac disease succumbing to positional asphyxia, as cardiac disease may be either unrelated to the terminal episode or, alternatively, may result in collapse predisposing to positional asphyxia. Victims of positional asphyxia do not extricate themselves from dangerous situations due to impairment of cognitive responses and coordination resulting from intoxication, sedation, neurological diseases, loss of consciousness, physical impairment or physical restraints.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21330187" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f6ad7b6a8f29104bb521d03208e88b86" rel="nofollow" data-download="{"attachment_id":41819045,"asset_id":21330187,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41819045/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42355626" href="https://adelaide1.academia.edu/RogerByard">Roger Byard</a><script data-card-contents-for-user="42355626" type="text/json">{"id":42355626,"first_name":"Roger","last_name":"Byard","domain_name":"adelaide1","page_name":"RogerByard","display_name":"Roger Byard","profile_url":"https://adelaide1.academia.edu/RogerByard?f_ri=7648","photo":"https://0.academia-photos.com/42355626/82188754/70791480/s65_roger.byard.png"}</script></span></span></li><li class="js-paper-rank-work_21330187 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21330187"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21330187, container: ".js-paper-rank-work_21330187", }); 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Examination of autopsy files at Forensic Science SA revealed instances where positional asphyxia resulted from inadvertent positioning that compromised respiration due to intoxication, multiple sclerosis, epilepsy, Parkinson disease, Steele-Richardson-Olszewski syndrome, Lafora disease and quadriplegia. While the manner of death was accidental in most cases, in one instance suicide could not be ruled out. We would not exclude the possibility of individuals with significant cardiac disease succumbing to positional asphyxia, as cardiac disease may be either unrelated to the terminal episode or, alternatively, may result in collapse predisposing to positional asphyxia. Victims of positional asphyxia do not extricate themselves from dangerous situations due to impairment of cognitive responses and coordination resulting from intoxication, sedation, neurological diseases, loss of consciousness, physical impairment or physical restraints.","downloadable_attachments":[{"id":41819045,"asset_id":21330187,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42355626,"first_name":"Roger","last_name":"Byard","domain_name":"adelaide1","page_name":"RogerByard","display_name":"Roger Byard","profile_url":"https://adelaide1.academia.edu/RogerByard?f_ri=7648","photo":"https://0.academia-photos.com/42355626/82188754/70791480/s65_roger.byard.png"}],"research_interests":[{"id":3097,"name":"Multiple sclerosis","url":"https://www.academia.edu/Documents/in/Multiple_sclerosis?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":13397,"name":"Forensic Medicine","url":"https://www.academia.edu/Documents/in/Forensic_Medicine?f_ri=7648","nofollow":true},{"id":82598,"name":"Accidents","url":"https://www.academia.edu/Documents/in/Accidents?f_ri=7648","nofollow":true},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=7648"},{"id":228356,"name":"Posture","url":"https://www.academia.edu/Documents/in/Posture?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":291259,"name":"Quadriplegia","url":"https://www.academia.edu/Documents/in/Quadriplegia?f_ri=7648"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=7648"},{"id":964578,"name":"Unconsciousness","url":"https://www.academia.edu/Documents/in/Unconsciousness?f_ri=7648"},{"id":976220,"name":"Physical Restraint","url":"https://www.academia.edu/Documents/in/Physical_Restraint?f_ri=7648"},{"id":1541077,"name":"Parkinson Disease","url":"https://www.academia.edu/Documents/in/Parkinson_Disease?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_69070446" data-work_id="69070446" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/69070446/Is_the_restricted_ketogenic_diet_a_viable_alternative_to_the_standard_of_care_for_managing_malignant_brain_cancer">Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Malignant brain cancer persists as a major disease of morbidity and mortality. The failure to recognize brain cancer as a disease of energy metabolism has contributed in large part to the failure in management. As long as brain tumor... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_69070446" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Malignant brain cancer persists as a major disease of morbidity and mortality. The failure to recognize brain cancer as a disease of energy metabolism has contributed in large part to the failure in management. As long as brain tumor cells have access to glucose and glutamine, the disease will progress. The current standard of care provides brain tumors with access to glucose and glutamine. The high fat low carbohydrate ketogenic diet (KD) will target glucose availability and possibly that of glutamine when administered in carefully restricted amounts to reduce total caloric intake and circulating levels of glucose. The restricted KD (RKD) targets major signaling pathways associated with glucose and glutamine metabolism including the IGF-1/PI3K/Akt/Hif pathway. The RKD is anti-angiogenic, anti-invasive, anti-inflammatory, and pro-apoptotic when evaluated in mice with malignant brain cancer. The therapeutic efficacy of the restricted KD can be enhanced when combined with drugs that also target glucose and glutamine. Therapeutic efficacy of the RKD was also seen against malignant gliomas in human case reports. Hence, the RKD can be an effective non-toxic therapeutic option to the current standard of care for inhibiting the growth and invasive properties of malignant brain cancer.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/69070446" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5571ecfee4c0a6ae52025fb9d1a04a57" rel="nofollow" data-download="{"attachment_id":79309269,"asset_id":69070446,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/79309269/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="133109080" href="https://independent.academia.edu/PurnaMukherjee2">Purna Mukherjee</a><script data-card-contents-for-user="133109080" type="text/json">{"id":133109080,"first_name":"Purna","last_name":"Mukherjee","domain_name":"independent","page_name":"PurnaMukherjee2","display_name":"Purna Mukherjee","profile_url":"https://independent.academia.edu/PurnaMukherjee2?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_69070446 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="69070446"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 69070446, container: ".js-paper-rank-work_69070446", }); 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The failure to recognize brain cancer as a disease of energy metabolism has contributed in large part to the failure in management. As long as brain tumor cells have access to glucose and glutamine, the disease will progress. The current standard of care provides brain tumors with access to glucose and glutamine. The high fat low carbohydrate ketogenic diet (KD) will target glucose availability and possibly that of glutamine when administered in carefully restricted amounts to reduce total caloric intake and circulating levels of glucose. The restricted KD (RKD) targets major signaling pathways associated with glucose and glutamine metabolism including the IGF-1/PI3K/Akt/Hif pathway. The RKD is anti-angiogenic, anti-invasive, anti-inflammatory, and pro-apoptotic when evaluated in mice with malignant brain cancer. The therapeutic efficacy of the restricted KD can be enhanced when combined with drugs that also target glucose and glutamine. Therapeutic efficacy of the RKD was also seen against malignant gliomas in human case reports. Hence, the RKD can be an effective non-toxic therapeutic option to the current standard of care for inhibiting the growth and invasive properties of malignant brain cancer.","downloadable_attachments":[{"id":79309269,"asset_id":69070446,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":133109080,"first_name":"Purna","last_name":"Mukherjee","domain_name":"independent","page_name":"PurnaMukherjee2","display_name":"Purna Mukherjee","profile_url":"https://independent.academia.edu/PurnaMukherjee2?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=7648","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=7648","nofollow":true},{"id":36213,"name":"Energy Metabolism","url":"https://www.academia.edu/Documents/in/Energy_Metabolism?f_ri=7648","nofollow":true},{"id":71289,"name":"Glucose","url":"https://www.academia.edu/Documents/in/Glucose?f_ri=7648"},{"id":81805,"name":"Calorie restriction","url":"https://www.academia.edu/Documents/in/Calorie_restriction?f_ri=7648"},{"id":91499,"name":"Glioblastoma","url":"https://www.academia.edu/Documents/in/Glioblastoma?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":766081,"name":"Caloric Restriction","url":"https://www.academia.edu/Documents/in/Caloric_Restriction?f_ri=7648"},{"id":1010274,"name":"Standard of Care","url":"https://www.academia.edu/Documents/in/Standard_of_Care?f_ri=7648"},{"id":1425045,"name":"Brain Neoplasms","url":"https://www.academia.edu/Documents/in/Brain_Neoplasms?f_ri=7648"},{"id":1893820,"name":"Ketogenic diet","url":"https://www.academia.edu/Documents/in/Ketogenic_diet?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_11041550 coauthored" data-work_id="11041550" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11041550/_Campylobacter_fetus_bacteremia_complicating_a_dysenteric_syndrome_in_a_young_epileptic_">[Campylobacter fetus bacteremia complicating a dysenteric syndrome in a young epileptic]</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Le sommaire de ce numéro <a href="http://www.john-libbey-eurotext.fr/fr/" rel="nofollow">http://www.john-libbey-eurotext.fr/fr/</a> revues/bio rech/abc/sommaire.md?type= text.html Montrouge, le 21/10/2013 Ahmed Aimen Bentorki Vous trouverez ci-après le tiréà part de votre article au formatélectronique... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_11041550" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Le sommaire de ce numéro <a href="http://www.john-libbey-eurotext.fr/fr/" rel="nofollow">http://www.john-libbey-eurotext.fr/fr/</a> revues/bio rech/abc/sommaire.md?type= text.html Montrouge, le 21/10/2013 Ahmed Aimen Bentorki Vous trouverez ci-après le tiréà part de votre article au formatélectronique (pdf) : Bactériémie à Campylobacter fetus compliquant un syndrome dysentérique chez un jeune épileptique paru dans Annales de biologie clinique, 2013, Volume 71, Numéro 5 John Libbey Eurotext Ce tiréà part numérique vous est délivré pour votre propre usage et ne peutêtre transmisà des tiers qu'à des fins de recherches personnelles ou scientifiques. En aucun cas, il ne doit faire l'objet d'une distribution ou d'une utilisation promotionnelle, commerciale ou publicitaire. Tous droits de reproduction, d'adaptation, de traduction et de diffusion réservés pour tous pays. Résumé. Les infections à Campylobacter fetus (C. fetus) sont très rares et il s'agit le plus souvent de septicémies chez des patients âgés et immunodéprimés. Nous rapportons ici une observation originale d'une bactériémie compliquant une diarrhée aiguë glaireuse à C. fetus chez un jeune épileptique ne présentant aucun des facteurs de risque connus. Notre observation suggère qu'en dehors d'un facteur de risque connu, le traitement antiépileptique pourrait exposer à un plus grand risque de diffusion hématogène de C. fetus.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11041550" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0a631bc2396532ca842a7d3759d1df2b" rel="nofollow" data-download="{"attachment_id":46950642,"asset_id":11041550,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46950642/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="26711204" href="https://independent.academia.edu/AhmedBentorki">Ahmed Bentorki</a><script data-card-contents-for-user="26711204" type="text/json">{"id":26711204,"first_name":"Ahmed","last_name":"Bentorki","domain_name":"independent","page_name":"AhmedBentorki","display_name":"Ahmed Bentorki","profile_url":"https://independent.academia.edu/AhmedBentorki?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-11041550">+1</span><div class="hidden js-additional-users-11041550"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/AdelGouri">Adel Gouri</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-11041550'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-11041550').html(); 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container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_11041550 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="11041550"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 11041550; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=11041550]").text(description); $(".js-view-count-work_11041550").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_11041550").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="11041550"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="47884" rel="nofollow" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a>, <script data-card-contents-for-ri="47884" type="text/json">{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="525310" rel="nofollow" href="https://www.academia.edu/Documents/in/Bacteremia">Bacteremia</a>, <script data-card-contents-for-ri="525310" type="text/json">{"id":525310,"name":"Bacteremia","url":"https://www.academia.edu/Documents/in/Bacteremia?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="975389" rel="nofollow" href="https://www.academia.edu/Documents/in/Dysentery">Dysentery</a><script data-card-contents-for-ri="975389" type="text/json">{"id":975389,"name":"Dysentery","url":"https://www.academia.edu/Documents/in/Dysentery?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=11041550]'), work: {"id":11041550,"title":"[Campylobacter fetus bacteremia complicating a dysenteric syndrome in a young epileptic]","created_at":"2015-02-24T03:35:08.037-08:00","url":"https://www.academia.edu/11041550/_Campylobacter_fetus_bacteremia_complicating_a_dysenteric_syndrome_in_a_young_epileptic_?f_ri=7648","dom_id":"work_11041550","summary":"Le sommaire de ce numéro http://www.john-libbey-eurotext.fr/fr/ revues/bio rech/abc/sommaire.md?type= text.html Montrouge, le 21/10/2013 Ahmed Aimen Bentorki Vous trouverez ci-après le tiréà part de votre article au formatélectronique (pdf) : Bactériémie à Campylobacter fetus compliquant un syndrome dysentérique chez un jeune épileptique paru dans Annales de biologie clinique, 2013, Volume 71, Numéro 5 John Libbey Eurotext Ce tiréà part numérique vous est délivré pour votre propre usage et ne peutêtre transmisà des tiers qu'à des fins de recherches personnelles ou scientifiques. En aucun cas, il ne doit faire l'objet d'une distribution ou d'une utilisation promotionnelle, commerciale ou publicitaire. Tous droits de reproduction, d'adaptation, de traduction et de diffusion réservés pour tous pays. Résumé. Les infections à Campylobacter fetus (C. fetus) sont très rares et il s'agit le plus souvent de septicémies chez des patients âgés et immunodéprimés. Nous rapportons ici une observation originale d'une bactériémie compliquant une diarrhée aiguë glaireuse à C. fetus chez un jeune épileptique ne présentant aucun des facteurs de risque connus. Notre observation suggère qu'en dehors d'un facteur de risque connu, le traitement antiépileptique pourrait exposer à un plus grand risque de diffusion hématogène de C. fetus.","downloadable_attachments":[{"id":46950642,"asset_id":11041550,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":26711204,"first_name":"Ahmed","last_name":"Bentorki","domain_name":"independent","page_name":"AhmedBentorki","display_name":"Ahmed Bentorki","profile_url":"https://independent.academia.edu/AhmedBentorki?f_ri=7648","photo":"/images/s65_no_pic.png"},{"id":26413417,"first_name":"Adel","last_name":"Gouri","domain_name":"independent","page_name":"AdelGouri","display_name":"Adel Gouri","profile_url":"https://independent.academia.edu/AdelGouri?f_ri=7648","photo":"https://0.academia-photos.com/26413417/8702935/17886320/s65_adel.gouri.jpg"}],"research_interests":[{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=7648","nofollow":true},{"id":525310,"name":"Bacteremia","url":"https://www.academia.edu/Documents/in/Bacteremia?f_ri=7648","nofollow":true},{"id":975389,"name":"Dysentery","url":"https://www.academia.edu/Documents/in/Dysentery?f_ri=7648","nofollow":true},{"id":1225171,"name":"Syndrome","url":"https://www.academia.edu/Documents/in/Syndrome?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13701246" data-work_id="13701246" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13701246/Concentrations_of_Stiripentol_in_Children_and_Adults_With_Epilepsy">Concentrations of Stiripentol in Children and Adults With Epilepsy</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Stiripentol (STP) was approved as an orphan drug in 2007 in Europe as adjunctive therapy with valproic acid (VPA) and clobazam (CLB) for Dravet syndrome. Dravet syndrome is a highly pharmacoresistant form of epilepsy, which... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13701246" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Stiripentol (STP) was approved as an orphan drug in 2007 in Europe as adjunctive therapy with valproic acid (VPA) and clobazam (CLB) for Dravet syndrome. Dravet syndrome is a highly pharmacoresistant form of epilepsy, which starts in early childhood. Data about STP pharmacokinetics and interactions are still limited and in part inconsistent. The aim of our study was to analyze the effect of age, gender, daily STP dose per body weight (milligrams per kilogram), VPA, CLB, and enzyme-inducing antiepileptic drugs on STP concentration-to-dose ratio (CDR), STP clearance, and STP trough concentrations.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13701246" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="41d12b544eeb187f651ef5d17769e3d4" rel="nofollow" data-download="{"attachment_id":45038351,"asset_id":13701246,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45038351/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32835928" href="https://independent.academia.edu/ElisabethKornmerker">Elisabeth Korn-merker</a><script data-card-contents-for-user="32835928" type="text/json">{"id":32835928,"first_name":"Elisabeth","last_name":"Korn-merker","domain_name":"independent","page_name":"ElisabethKornmerker","display_name":"Elisabeth Korn-merker","profile_url":"https://independent.academia.edu/ElisabethKornmerker?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13701246 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13701246"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13701246, container: ".js-paper-rank-work_13701246", }); 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$(".js-view-count[data-work-id=13701246]").text(description); $(".js-view-count-work_13701246").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13701246").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13701246"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="524" rel="nofollow" href="https://www.academia.edu/Documents/in/Analytical_Chemistry">Analytical Chemistry</a>, <script data-card-contents-for-ri="524" type="text/json">{"id":524,"name":"Analytical Chemistry","url":"https://www.academia.edu/Documents/in/Analytical_Chemistry?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="11558" rel="nofollow" href="https://www.academia.edu/Documents/in/Drug_interactions">Drug interactions</a>, <script data-card-contents-for-ri="11558" type="text/json">{"id":11558,"name":"Drug interactions","url":"https://www.academia.edu/Documents/in/Drug_interactions?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="58380" rel="nofollow" href="https://www.academia.edu/Documents/in/Therapeutic_drug_monitoring">Therapeutic drug monitoring</a><script data-card-contents-for-ri="58380" type="text/json">{"id":58380,"name":"Therapeutic drug monitoring","url":"https://www.academia.edu/Documents/in/Therapeutic_drug_monitoring?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13701246]'), work: {"id":13701246,"title":"Concentrations of Stiripentol in Children and Adults With Epilepsy","created_at":"2015-07-06T06:50:48.045-07:00","url":"https://www.academia.edu/13701246/Concentrations_of_Stiripentol_in_Children_and_Adults_With_Epilepsy?f_ri=7648","dom_id":"work_13701246","summary":"Background: Stiripentol (STP) was approved as an orphan drug in 2007 in Europe as adjunctive therapy with valproic acid (VPA) and clobazam (CLB) for Dravet syndrome. Dravet syndrome is a highly pharmacoresistant form of epilepsy, which starts in early childhood. Data about STP pharmacokinetics and interactions are still limited and in part inconsistent. The aim of our study was to analyze the effect of age, gender, daily STP dose per body weight (milligrams per kilogram), VPA, CLB, and enzyme-inducing antiepileptic drugs on STP concentration-to-dose ratio (CDR), STP clearance, and STP trough concentrations.","downloadable_attachments":[{"id":45038351,"asset_id":13701246,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32835928,"first_name":"Elisabeth","last_name":"Korn-merker","domain_name":"independent","page_name":"ElisabethKornmerker","display_name":"Elisabeth Korn-merker","profile_url":"https://independent.academia.edu/ElisabethKornmerker?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":524,"name":"Analytical Chemistry","url":"https://www.academia.edu/Documents/in/Analytical_Chemistry?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":11558,"name":"Drug interactions","url":"https://www.academia.edu/Documents/in/Drug_interactions?f_ri=7648","nofollow":true},{"id":58380,"name":"Therapeutic drug monitoring","url":"https://www.academia.edu/Documents/in/Therapeutic_drug_monitoring?f_ri=7648","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=7648"},{"id":123230,"name":"Regression Analysis","url":"https://www.academia.edu/Documents/in/Regression_Analysis?f_ri=7648"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=7648"},{"id":413192,"name":"Sex Factors","url":"https://www.academia.edu/Documents/in/Sex_Factors?f_ri=7648"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=7648"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=7648"},{"id":564878,"name":"Body Weight","url":"https://www.academia.edu/Documents/in/Body_Weight?f_ri=7648"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy?f_ri=7648"},{"id":912835,"name":"Phenytoin","url":"https://www.academia.edu/Documents/in/Phenytoin?f_ri=7648"},{"id":1147504,"name":"Phenobarbital","url":"https://www.academia.edu/Documents/in/Phenobarbital?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_23755063 coauthored" data-work_id="23755063" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/23755063/Psychopathology_in_Adults_with_Autism_and_Intellectual_Disability">Psychopathology in Adults with Autism and Intellectual Disability</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">There have been few studies of psychopathology in adult with autism. This study examined psychiatric co-morbidity in 147 adults with intellectual disability (ID) and autism and 605 adults with ID but without autism. After controlling for... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_23755063" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">There have been few studies of psychopathology in adult with autism. This study examined psychiatric co-morbidity in 147 adults with intellectual disability (ID) and autism and 605 adults with ID but without autism. After controlling for the effects of gender, age, psychotropic medication and level of ID, people with autism and ID were no more likely to receive a psychiatric diagnosis than people with ID only. People with autism were less likely to receive a diagnosis of personality disorder. These findings cast doubts on the hypothesis that adults with ID and autism are more vulnerable to certain psychiatric disorders than non-autistic adults with ID.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/23755063" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4445b7841d67becea180b13565749877" rel="nofollow" data-download="{"attachment_id":44194727,"asset_id":23755063,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44194727/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="45965763" href="https://independent.academia.edu/CostelloH">H. Costello</a><script data-card-contents-for-user="45965763" type="text/json">{"id":45965763,"first_name":"H.","last_name":"Costello","domain_name":"independent","page_name":"CostelloH","display_name":"H. Costello","profile_url":"https://independent.academia.edu/CostelloH?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-23755063">+1</span><div class="hidden js-additional-users-23755063"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/ETsakanikos">E. Tsakanikos</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-23755063'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-23755063').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_23755063 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="23755063"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 23755063, container: ".js-paper-rank-work_23755063", }); });</script></li><li class="js-percentile-work_23755063 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 23755063; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_23755063"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_23755063 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="23755063"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 23755063; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=23755063]").text(description); $(".js-view-count-work_23755063").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_23755063").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="23755063"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="922" rel="nofollow" href="https://www.academia.edu/Documents/in/Education">Education</a>, <script data-card-contents-for-ri="922" type="text/json">{"id":922,"name":"Education","url":"https://www.academia.edu/Documents/in/Education?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2249" rel="nofollow" href="https://www.academia.edu/Documents/in/Autism">Autism</a>, <script data-card-contents-for-ri="2249" type="text/json">{"id":2249,"name":"Autism","url":"https://www.academia.edu/Documents/in/Autism?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a><script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=23755063]'), work: {"id":23755063,"title":"Psychopathology in Adults with Autism and Intellectual Disability","created_at":"2016-03-29T00:53:39.367-07:00","url":"https://www.academia.edu/23755063/Psychopathology_in_Adults_with_Autism_and_Intellectual_Disability?f_ri=7648","dom_id":"work_23755063","summary":"There have been few studies of psychopathology in adult with autism. This study examined psychiatric co-morbidity in 147 adults with intellectual disability (ID) and autism and 605 adults with ID but without autism. After controlling for the effects of gender, age, psychotropic medication and level of ID, people with autism and ID were no more likely to receive a psychiatric diagnosis than people with ID only. People with autism were less likely to receive a diagnosis of personality disorder. These findings cast doubts on the hypothesis that adults with ID and autism are more vulnerable to certain psychiatric disorders than non-autistic adults with ID.","downloadable_attachments":[{"id":44194727,"asset_id":23755063,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":45965763,"first_name":"H.","last_name":"Costello","domain_name":"independent","page_name":"CostelloH","display_name":"H. Costello","profile_url":"https://independent.academia.edu/CostelloH?f_ri=7648","photo":"/images/s65_no_pic.png"},{"id":57829899,"first_name":"E.","last_name":"Tsakanikos","domain_name":"independent","page_name":"ETsakanikos","display_name":"E. Tsakanikos","profile_url":"https://independent.academia.edu/ETsakanikos?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":922,"name":"Education","url":"https://www.academia.edu/Documents/in/Education?f_ri=7648","nofollow":true},{"id":2249,"name":"Autism","url":"https://www.academia.edu/Documents/in/Autism?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=7648","nofollow":true},{"id":23868,"name":"Intellectual Disability","url":"https://www.academia.edu/Documents/in/Intellectual_Disability?f_ri=7648"},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=7648"},{"id":100558,"name":"Personality Disorder","url":"https://www.academia.edu/Documents/in/Personality_Disorder?f_ri=7648"},{"id":171144,"name":"Mental Disorders","url":"https://www.academia.edu/Documents/in/Mental_Disorders?f_ri=7648"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=7648"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=7648"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires?f_ri=7648"},{"id":1627527,"name":"Cognition disorders","url":"https://www.academia.edu/Documents/in/Cognition_disorders?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16985074" data-work_id="16985074" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16985074/Seroprevalence_of_Taenia_solium_antibodies_in_Vellore_district_south_India">Seroprevalence of Taenia solium antibodies in Vellore district, south India</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">a v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j o u r n a l h o m e p a g e : w w w . e l s e v i e r h e a l t h . c o m / j o u r n a l s / t r s t</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16985074" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a 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data-card-contents-for-user="36504666" type="text/json">{"id":36504666,"first_name":"Jayaprakash","last_name":"Muliyil","domain_name":"tnmmu","page_name":"JayaprakashMuliyil","display_name":"Jayaprakash Muliyil","profile_url":"https://tnmmu.academia.edu/JayaprakashMuliyil?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_16985074 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16985074"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16985074, container: ".js-paper-rank-work_16985074", }); });</script></li><li class="js-percentile-work_16985074 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x 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}); });</script></span><script>$(function() { $(".js-view-count-work_16985074").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16985074"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="159" rel="nofollow" href="https://www.academia.edu/Documents/in/Microbiology">Microbiology</a>, <script data-card-contents-for-ri="159" type="text/json">{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6947" rel="nofollow" href="https://www.academia.edu/Documents/in/Medical_Microbiology">Medical Microbiology</a>, <script data-card-contents-for-ri="6947" type="text/json">{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="20771" rel="nofollow" href="https://www.academia.edu/Documents/in/South_India">South India</a><script data-card-contents-for-ri="20771" type="text/json">{"id":20771,"name":"South India","url":"https://www.academia.edu/Documents/in/South_India?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16985074]'), work: {"id":16985074,"title":"Seroprevalence of Taenia solium antibodies in Vellore district, south India","created_at":"2015-10-19T02:07:12.226-07:00","url":"https://www.academia.edu/16985074/Seroprevalence_of_Taenia_solium_antibodies_in_Vellore_district_south_India?f_ri=7648","dom_id":"work_16985074","summary":"a v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j o u r n a l h o m e p a g e : w w w . e l s e v i e r h e a l t h . c o m / j o u r n a l s / t r s t","downloadable_attachments":[{"id":39292270,"asset_id":16985074,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36504666,"first_name":"Jayaprakash","last_name":"Muliyil","domain_name":"tnmmu","page_name":"JayaprakashMuliyil","display_name":"Jayaprakash Muliyil","profile_url":"https://tnmmu.academia.edu/JayaprakashMuliyil?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology?f_ri=7648","nofollow":true},{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":20771,"name":"South India","url":"https://www.academia.edu/Documents/in/South_India?f_ri=7648","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=7648"},{"id":22772,"name":"Urban Health","url":"https://www.academia.edu/Documents/in/Urban_Health?f_ri=7648"},{"id":37881,"name":"Animal Husbandry","url":"https://www.academia.edu/Documents/in/Animal_Husbandry?f_ri=7648"},{"id":56691,"name":"Rural Health","url":"https://www.academia.edu/Documents/in/Rural_Health?f_ri=7648"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=7648"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=7648"},{"id":419370,"name":"Swine","url":"https://www.academia.edu/Documents/in/Swine?f_ri=7648"},{"id":890740,"name":"Neurocysticercosis","url":"https://www.academia.edu/Documents/in/Neurocysticercosis?f_ri=7648"},{"id":1272906,"name":"Enzyme Linked Immunosorbent Assay","url":"https://www.academia.edu/Documents/in/Enzyme_Linked_Immunosorbent_Assay?f_ri=7648"},{"id":2060319,"name":"Taenia solium","url":"https://www.academia.edu/Documents/in/Taenia_solium?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_12509220 coauthored" data-work_id="12509220" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/12509220/Mental_Health_Perspectives_of_Epilepsy_Focus_on_Anxiety_Disorders">Mental Health Perspectives of Epilepsy: Focus on Anxiety Disorders</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/12509220" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="659982cb88eae9ce49b7165606cb4f6d" rel="nofollow" data-download="{"attachment_id":37699205,"asset_id":12509220,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/37699205/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="13928707" href="https://kgmcindia.academia.edu/SujitKar">Sujit Kar</a><script data-card-contents-for-user="13928707" type="text/json">{"id":13928707,"first_name":"Sujit","last_name":"Kar","domain_name":"kgmcindia","page_name":"SujitKar","display_name":"Sujit Kar","profile_url":"https://kgmcindia.academia.edu/SujitKar?f_ri=7648","photo":"https://0.academia-photos.com/13928707/3854010/4509091/s65_sujit.kar.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-12509220">+2</span><div class="hidden js-additional-users-12509220"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/BheemsainTekkalaki">Bheemsain Tekkalaki</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/RahulSaha12">Rahul Saha</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-12509220'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-12509220').html(); } } new 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container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_12509220 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="12509220"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12509220; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12509220]").text(description); $(".js-view-count-work_12509220").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_12509220").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="12509220"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="1314" rel="nofollow" href="https://www.academia.edu/Documents/in/Anxiety_Disorders">Anxiety Disorders</a>, <script data-card-contents-for-ri="1314" type="text/json">{"id":1314,"name":"Anxiety Disorders","url":"https://www.academia.edu/Documents/in/Anxiety_Disorders?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a><script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=12509220]'), work: {"id":12509220,"title":"Mental Health Perspectives of Epilepsy: Focus on Anxiety Disorders","created_at":"2015-05-21T06:50:03.968-07:00","url":"https://www.academia.edu/12509220/Mental_Health_Perspectives_of_Epilepsy_Focus_on_Anxiety_Disorders?f_ri=7648","dom_id":"work_12509220","summary":null,"downloadable_attachments":[{"id":37699205,"asset_id":12509220,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":13928707,"first_name":"Sujit","last_name":"Kar","domain_name":"kgmcindia","page_name":"SujitKar","display_name":"Sujit Kar","profile_url":"https://kgmcindia.academia.edu/SujitKar?f_ri=7648","photo":"https://0.academia-photos.com/13928707/3854010/4509091/s65_sujit.kar.jpg"},{"id":31439551,"first_name":"Bheemsain","last_name":"Tekkalaki","domain_name":"independent","page_name":"BheemsainTekkalaki","display_name":"Bheemsain Tekkalaki","profile_url":"https://independent.academia.edu/BheemsainTekkalaki?f_ri=7648","photo":"/images/s65_no_pic.png"},{"id":31443022,"first_name":"Rahul","last_name":"Saha","domain_name":"independent","page_name":"RahulSaha12","display_name":"Rahul Saha","profile_url":"https://independent.academia.edu/RahulSaha12?f_ri=7648","photo":"https://0.academia-photos.com/31443022/144749294/134275620/s65_rahul.saha.png"}],"research_interests":[{"id":1314,"name":"Anxiety Disorders","url":"https://www.academia.edu/Documents/in/Anxiety_Disorders?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_60953772" data-work_id="60953772" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/60953772/Successful_re_introduction_of_lamotrigine_after_initial_rash">Successful re-introduction of lamotrigine after initial rash</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The aim of this study was to determine whether lamotrigine can be reintroduced safely and with a benefit in young people who previously had a mild rash associated with the first introduction of this drug. In the first 150 young people... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_60953772" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The aim of this study was to determine whether lamotrigine can be reintroduced safely and with a benefit in young people who previously had a mild rash associated with the first introduction of this drug. In the first 150 young people (5-19 years old) treated with lamotrigine in a special centre for epilepsy, seven developed a mild rash soon after starting the drug. In none of these cases was the rash severe, nor was there any mucous membrane involvement. The lamotrigine was stopped immediately when the rash was identified and was subsequently reintroduced , using a special very-low-dose-escalation regime, starting with 0.1 mg/day total daily dose, after periods ranging from 47 to 236 days. It was possible to reintroduce the lamotrigine without recurrence of persistent rash and without any adverse effects in all seven cases. The re-introduction of lamotrigine was associated with improvement in five of the seven cases. It is recommended that lamotrigine is stopped as soon as any rash attributable to the drug develops but it may be possible to reintroduce the drug after mild rash using a very-slow-dose-escalation regime, with a benefit in at least some cases.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/60953772" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1cb4d37647d30af5705d88b55496511b" rel="nofollow" data-download="{"attachment_id":74172317,"asset_id":60953772,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/74172317/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38381035" href="https://independent.academia.edu/FrankBesag">Frank Besag</a><script data-card-contents-for-user="38381035" type="text/json">{"id":38381035,"first_name":"Frank","last_name":"Besag","domain_name":"independent","page_name":"FrankBesag","display_name":"Frank Besag","profile_url":"https://independent.academia.edu/FrankBesag?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_60953772 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="60953772"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 60953772, container: ".js-paper-rank-work_60953772", }); });</script></li><li class="js-percentile-work_60953772 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 60953772; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_60953772"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_60953772 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="60953772"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 60953772; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=60953772]").text(description); $(".js-view-count-work_60953772").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_60953772").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="60953772"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="221" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychology">Psychology</a>, <script data-card-contents-for-ri="221" type="text/json">{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="13841" rel="nofollow" href="https://www.academia.edu/Documents/in/Drug_development">Drug development</a><script data-card-contents-for-ri="13841" type="text/json">{"id":13841,"name":"Drug development","url":"https://www.academia.edu/Documents/in/Drug_development?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=60953772]'), work: {"id":60953772,"title":"Successful re-introduction of lamotrigine after initial rash","created_at":"2021-11-03T14:39:37.880-07:00","url":"https://www.academia.edu/60953772/Successful_re_introduction_of_lamotrigine_after_initial_rash?f_ri=7648","dom_id":"work_60953772","summary":"The aim of this study was to determine whether lamotrigine can be reintroduced safely and with a benefit in young people who previously had a mild rash associated with the first introduction of this drug. In the first 150 young people (5-19 years old) treated with lamotrigine in a special centre for epilepsy, seven developed a mild rash soon after starting the drug. In none of these cases was the rash severe, nor was there any mucous membrane involvement. The lamotrigine was stopped immediately when the rash was identified and was subsequently reintroduced , using a special very-low-dose-escalation regime, starting with 0.1 mg/day total daily dose, after periods ranging from 47 to 236 days. It was possible to reintroduce the lamotrigine without recurrence of persistent rash and without any adverse effects in all seven cases. The re-introduction of lamotrigine was associated with improvement in five of the seven cases. It is recommended that lamotrigine is stopped as soon as any rash attributable to the drug develops but it may be possible to reintroduce the drug after mild rash using a very-slow-dose-escalation regime, with a benefit in at least some cases.","downloadable_attachments":[{"id":74172317,"asset_id":60953772,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38381035,"first_name":"Frank","last_name":"Besag","domain_name":"independent","page_name":"FrankBesag","display_name":"Frank Besag","profile_url":"https://independent.academia.edu/FrankBesag?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=7648","nofollow":true},{"id":13841,"name":"Drug development","url":"https://www.academia.edu/Documents/in/Drug_development?f_ri=7648","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=7648"},{"id":51686,"name":"Seizure","url":"https://www.academia.edu/Documents/in/Seizure?f_ri=7648"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":801410,"name":"Triazines","url":"https://www.academia.edu/Documents/in/Triazines?f_ri=7648"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=7648"},{"id":1246554,"name":"SECONDARY PREVENTION","url":"https://www.academia.edu/Documents/in/SECONDARY_PREVENTION?f_ri=7648"},{"id":2463800,"name":"Severity of Illness Index","url":"https://www.academia.edu/Documents/in/Severity_of_Illness_Index?f_ri=7648"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=7648"},{"id":2601211,"name":"Adverse effect","url":"https://www.academia.edu/Documents/in/Adverse_effect?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_63704399" data-work_id="63704399" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/63704399/Reduced_degree_of_long_range_phase_synchrony_in_pathological_human_brain">Reduced degree of long-range phase synchrony in pathological human brain</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">In this paper multivariate spontaneous EEG signals from three broad groups of human subjects--control, seizure, and mania--were studied with the aim of investigating the possible effect of these pathologies on the degree of phase... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_63704399" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">In this paper multivariate spontaneous EEG signals from three broad groups of human subjects--control, seizure, and mania--were studied with the aim of investigating the possible effect of these pathologies on the degree of phase synchronization between cortical areas. The degree of phase synchrony was measured by two recently developed measures which are more suitable than classical indices like correlation or coherence when dealing with nonlinear and non-stationary signals like the EEG. Signals were reduced to seven frequency bands (delta, theta, alpha-1, alpha-2, beta-1, beta-2 and gamma) which were statistically compared between the normal and the other two groups. It was found that the degree of long-range synchrony was significantly reduced for both pathological groups as compared with the control group. No clear differences were found in the degrees of short-range synchrony.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/63704399" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="54ae8d464098e5a2055e07e876ad9c01" rel="nofollow" data-download="{"attachment_id":76045745,"asset_id":63704399,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/76045745/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="8940902" href="https://independent.academia.edu/ProfJoydeepBhattacharya">Prof. Joydeep Bhattacharya</a><script data-card-contents-for-user="8940902" type="text/json">{"id":8940902,"first_name":"Prof. Joydeep","last_name":"Bhattacharya","domain_name":"independent","page_name":"ProfJoydeepBhattacharya","display_name":"Prof. Joydeep Bhattacharya","profile_url":"https://independent.academia.edu/ProfJoydeepBhattacharya?f_ri=7648","photo":"https://0.academia-photos.com/8940902/24662593/23532980/s65_prof._joydeep.bhattacharya.jpg"}</script></span></span></li><li class="js-paper-rank-work_63704399 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="63704399"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 63704399, container: ".js-paper-rank-work_63704399", }); 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$(".js-view-count[data-work-id=63704399]").text(description); $(".js-view-count-work_63704399").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_63704399").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="63704399"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="221" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychology">Psychology</a>, <script data-card-contents-for-ri="221" type="text/json">{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="237" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3230" rel="nofollow" href="https://www.academia.edu/Documents/in/Bipolar_Disorder">Bipolar Disorder</a>, <script data-card-contents-for-ri="3230" type="text/json">{"id":3230,"name":"Bipolar Disorder","url":"https://www.academia.edu/Documents/in/Bipolar_Disorder?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a><script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=63704399]'), work: {"id":63704399,"title":"Reduced degree of long-range phase synchrony in pathological human brain","created_at":"2021-12-09T23:16:45.272-08:00","url":"https://www.academia.edu/63704399/Reduced_degree_of_long_range_phase_synchrony_in_pathological_human_brain?f_ri=7648","dom_id":"work_63704399","summary":"In this paper multivariate spontaneous EEG signals from three broad groups of human subjects--control, seizure, and mania--were studied with the aim of investigating the possible effect of these pathologies on the degree of phase synchronization between cortical areas. The degree of phase synchrony was measured by two recently developed measures which are more suitable than classical indices like correlation or coherence when dealing with nonlinear and non-stationary signals like the EEG. Signals were reduced to seven frequency bands (delta, theta, alpha-1, alpha-2, beta-1, beta-2 and gamma) which were statistically compared between the normal and the other two groups. It was found that the degree of long-range synchrony was significantly reduced for both pathological groups as compared with the control group. No clear differences were found in the degrees of short-range synchrony.","downloadable_attachments":[{"id":76045745,"asset_id":63704399,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":8940902,"first_name":"Prof. Joydeep","last_name":"Bhattacharya","domain_name":"independent","page_name":"ProfJoydeepBhattacharya","display_name":"Prof. Joydeep Bhattacharya","profile_url":"https://independent.academia.edu/ProfJoydeepBhattacharya?f_ri=7648","photo":"https://0.academia-photos.com/8940902/24662593/23532980/s65_prof._joydeep.bhattacharya.jpg"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=7648","nofollow":true},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=7648","nofollow":true},{"id":3230,"name":"Bipolar Disorder","url":"https://www.academia.edu/Documents/in/Bipolar_Disorder?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=7648"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=7648"},{"id":148995,"name":"Long Range","url":"https://www.academia.edu/Documents/in/Long_Range?f_ri=7648"},{"id":151841,"name":"Phase Synchronization","url":"https://www.academia.edu/Documents/in/Phase_Synchronization?f_ri=7648"},{"id":190905,"name":"Periodicity","url":"https://www.academia.edu/Documents/in/Periodicity?f_ri=7648"},{"id":203010,"name":"Human Brain","url":"https://www.academia.edu/Documents/in/Human_Brain?f_ri=7648"},{"id":979686,"name":"Human Subjects","url":"https://www.academia.edu/Documents/in/Human_Subjects?f_ri=7648"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=7648"},{"id":1631043,"name":"Control Group","url":"https://www.academia.edu/Documents/in/Control_Group?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_30423459" data-work_id="30423459" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/30423459/Supracondylar_femur_fracture_complicating_epileptic_insult_a_specific_and_under_diagnosed_complication">Supracondylar femur fracture complicating epileptic insult: a specific and under diagnosed complication?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">The user has requested enhancement of the downloaded file. All in-text references underlined in blue are added to the original document and are linked to publications on ResearchGate, letting you access and read them immediately.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/30423459" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a88081597a7fbeb8bbea1685a3a78810" rel="nofollow" data-download="{"attachment_id":50867134,"asset_id":30423459,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/50867134/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="57994967" href="https://independent.academia.edu/BertenCeulemans">Berten Ceulemans</a><script data-card-contents-for-user="57994967" type="text/json">{"id":57994967,"first_name":"Berten","last_name":"Ceulemans","domain_name":"independent","page_name":"BertenCeulemans","display_name":"Berten Ceulemans","profile_url":"https://independent.academia.edu/BertenCeulemans?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_30423459 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="30423459"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 30423459, container: ".js-paper-rank-work_30423459", }); });</script></li><li class="js-percentile-work_30423459 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30423459; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_30423459"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_30423459 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="30423459"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30423459; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30423459]").text(description); $(".js-view-count-work_30423459").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_30423459").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="30423459"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4228" rel="nofollow" href="https://www.academia.edu/Documents/in/Skeletal_muscle_biology">Skeletal muscle biology</a>, <script data-card-contents-for-ri="4228" type="text/json">{"id":4228,"name":"Skeletal muscle biology","url":"https://www.academia.edu/Documents/in/Skeletal_muscle_biology?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9112" rel="nofollow" href="https://www.academia.edu/Documents/in/Physical_Activity">Physical Activity</a>, <script data-card-contents-for-ri="9112" type="text/json">{"id":9112,"name":"Physical Activity","url":"https://www.academia.edu/Documents/in/Physical_Activity?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="17845" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebral_Palsy">Cerebral Palsy</a><script data-card-contents-for-ri="17845" type="text/json">{"id":17845,"name":"Cerebral Palsy","url":"https://www.academia.edu/Documents/in/Cerebral_Palsy?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=30423459]'), work: {"id":30423459,"title":"Supracondylar femur fracture complicating epileptic insult: a specific and under diagnosed complication?","created_at":"2016-12-13T08:16:55.128-08:00","url":"https://www.academia.edu/30423459/Supracondylar_femur_fracture_complicating_epileptic_insult_a_specific_and_under_diagnosed_complication?f_ri=7648","dom_id":"work_30423459","summary":"The user has requested enhancement of the downloaded file. All in-text references underlined in blue are added to the original document and are linked to publications on ResearchGate, letting you access and read them immediately.","downloadable_attachments":[{"id":50867134,"asset_id":30423459,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":57994967,"first_name":"Berten","last_name":"Ceulemans","domain_name":"independent","page_name":"BertenCeulemans","display_name":"Berten Ceulemans","profile_url":"https://independent.academia.edu/BertenCeulemans?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4228,"name":"Skeletal muscle biology","url":"https://www.academia.edu/Documents/in/Skeletal_muscle_biology?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":9112,"name":"Physical Activity","url":"https://www.academia.edu/Documents/in/Physical_Activity?f_ri=7648","nofollow":true},{"id":17845,"name":"Cerebral Palsy","url":"https://www.academia.edu/Documents/in/Cerebral_Palsy?f_ri=7648","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=7648"},{"id":23868,"name":"Intellectual Disability","url":"https://www.academia.edu/Documents/in/Intellectual_Disability?f_ri=7648"},{"id":63997,"name":"Osteoporosis","url":"https://www.academia.edu/Documents/in/Osteoporosis?f_ri=7648"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=7648"},{"id":78189,"name":"Knee","url":"https://www.academia.edu/Documents/in/Knee?f_ri=7648"},{"id":85904,"name":"Femur","url":"https://www.academia.edu/Documents/in/Femur?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":350931,"name":"Mechanical Stress","url":"https://www.academia.edu/Documents/in/Mechanical_Stress?f_ri=7648"},{"id":556021,"name":"Muscle contraction","url":"https://www.academia.edu/Documents/in/Muscle_contraction?f_ri=7648"},{"id":1114577,"name":"Vitamin D Deficiency","url":"https://www.academia.edu/Documents/in/Vitamin_D_Deficiency?f_ri=7648"},{"id":1225171,"name":"Syndrome","url":"https://www.academia.edu/Documents/in/Syndrome?f_ri=7648"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=7648"},{"id":1423006,"name":"General Population","url":"https://www.academia.edu/Documents/in/General_Population?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_11297341" data-work_id="11297341" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11297341/Extent_of_neocortical_resection_and_surgical_outcome_of_epilepsy_Intracranial_EEG_analysis">Extent of neocortical resection and surgical outcome of epilepsy: Intracranial EEG analysis</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Purpose: Intracranial electroencephalography (EEG) monitoring is an important process in the presurgical evaluation for epilepsy surgery. The objective of this study was to identify the ideal resection margin in neocortical epilepsy... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_11297341" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Purpose: Intracranial electroencephalography (EEG) monitoring is an important process in the presurgical evaluation for epilepsy surgery. The objective of this study was to identify the ideal resection margin in neocortical epilepsy guided by subdural electrodes. For this purpose, we investigated the relationship between the extent of resection guided by subdural electrodes and the outcome of epilepsy surgery. Methods: Intracranial EEG studies were analyzed in 177 consecutive patients who had undergone resective epilepsy surgery. We reviewed various intracranial EEG findings and resection extent. We analyzed the relationships between the surgical outcomes and intracranial EEG factors: the frequency, morphology, and distribution of ictalonset discharges, the propagation speed, and the time lag between clinical and intracranial ictal onset. We also investigated whether the extent of resection, including the area showing ictal rhythm and various interictal abnormalities-such as frequent interictal spikes, pathologic delta waves, and paroxysmal fast activity-influenced the surgical outcome. Results: Seventy-five patients (42%) were seizure free. A seizure-free outcome was significantly associated with a resection that included the area showing ictal spreading rhythm during the first 3 s or included all the electrodes showing pathologic delta waves or frequent interictal spikes. However, subgroup analysis revealed that the extent of resection did not affect the surgical outcome in lateral temporal lobe epilepsy. Conclusions: The extent of resection is closely associated with surgical outcome, especially in extratemporal lobe epilepsy. Resection that includes the area with total pathologic delta waves and frequent interictal spikes predicts a good surgical outcome.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11297341" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ff6728dfd49ba95df1fe2ce87bdd7dba" rel="nofollow" data-download="{"attachment_id":46768308,"asset_id":11297341,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46768308/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="27309344" href="https://independent.academia.edu/HyunKunKim">Hyun Kun Kim</a><script data-card-contents-for-user="27309344" type="text/json">{"id":27309344,"first_name":"Hyun Kun","last_name":"Kim","domain_name":"independent","page_name":"HyunKunKim","display_name":"Hyun Kun Kim","profile_url":"https://independent.academia.edu/HyunKunKim?f_ri=7648","photo":"https://0.academia-photos.com/27309344/7758442/8697379/s65_hyun_kun.kim.jpg_oh_6fcad056592c6b7246a1b95702124dee_oe_5589db33___gda___1434792873_ab4ff1b350a9d5664b8ac53ee20c5a9d"}</script></span></span></li><li class="js-paper-rank-work_11297341 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="11297341"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 11297341, container: ".js-paper-rank-work_11297341", }); 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$(".js-view-count[data-work-id=11297341]").text(description); $(".js-view-count-work_11297341").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_11297341").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="11297341"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="48" rel="nofollow" href="https://www.academia.edu/Documents/in/Engineering">Engineering</a>, <script data-card-contents-for-ri="48" type="text/json">{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10904" rel="nofollow" href="https://www.academia.edu/Documents/in/Electroencephalography">Electroencephalography</a>, <script data-card-contents-for-ri="10904" type="text/json">{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a><script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=11297341]'), work: {"id":11297341,"title":"Extent of neocortical resection and surgical outcome of epilepsy: Intracranial EEG analysis","created_at":"2015-03-05T17:27:55.409-08:00","url":"https://www.academia.edu/11297341/Extent_of_neocortical_resection_and_surgical_outcome_of_epilepsy_Intracranial_EEG_analysis?f_ri=7648","dom_id":"work_11297341","summary":"Purpose: Intracranial electroencephalography (EEG) monitoring is an important process in the presurgical evaluation for epilepsy surgery. The objective of this study was to identify the ideal resection margin in neocortical epilepsy guided by subdural electrodes. For this purpose, we investigated the relationship between the extent of resection guided by subdural electrodes and the outcome of epilepsy surgery. Methods: Intracranial EEG studies were analyzed in 177 consecutive patients who had undergone resective epilepsy surgery. We reviewed various intracranial EEG findings and resection extent. We analyzed the relationships between the surgical outcomes and intracranial EEG factors: the frequency, morphology, and distribution of ictalonset discharges, the propagation speed, and the time lag between clinical and intracranial ictal onset. We also investigated whether the extent of resection, including the area showing ictal rhythm and various interictal abnormalities-such as frequent interictal spikes, pathologic delta waves, and paroxysmal fast activity-influenced the surgical outcome. Results: Seventy-five patients (42%) were seizure free. A seizure-free outcome was significantly associated with a resection that included the area showing ictal spreading rhythm during the first 3 s or included all the electrodes showing pathologic delta waves or frequent interictal spikes. However, subgroup analysis revealed that the extent of resection did not affect the surgical outcome in lateral temporal lobe epilepsy. Conclusions: The extent of resection is closely associated with surgical outcome, especially in extratemporal lobe epilepsy. Resection that includes the area with total pathologic delta waves and frequent interictal spikes predicts a good surgical outcome.","downloadable_attachments":[{"id":46768308,"asset_id":11297341,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":27309344,"first_name":"Hyun Kun","last_name":"Kim","domain_name":"independent","page_name":"HyunKunKim","display_name":"Hyun Kun Kim","profile_url":"https://independent.academia.edu/HyunKunKim?f_ri=7648","photo":"https://0.academia-photos.com/27309344/7758442/8697379/s65_hyun_kun.kim.jpg_oh_6fcad056592c6b7246a1b95702124dee_oe_5589db33___gda___1434792873_ab4ff1b350a9d5664b8ac53ee20c5a9d"}],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=7648","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=7648"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=7648"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=7648"},{"id":228487,"name":"Epilepsia","url":"https://www.academia.edu/Documents/in/Epilepsia?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":263020,"name":"Clinical Neurophysiology","url":"https://www.academia.edu/Documents/in/Clinical_Neurophysiology?f_ri=7648"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=7648"},{"id":493558,"name":"Neocortex","url":"https://www.academia.edu/Documents/in/Neocortex?f_ri=7648"},{"id":846015,"name":"Electrodes","url":"https://www.academia.edu/Documents/in/Electrodes?f_ri=7648"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_11370528" data-work_id="11370528" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11370528/Antiepileptic_drugs_and_suicidality_An_expert_consensus_statement_from_the_Task_Force_on_Therapeutic_strategies_of_the_ILAE_Commission_on_Neuropsychobiology">Antiepileptic drugs and suicidality: An expert consensus statement from the Task Force on Therapeutic strategies of the ILAE Commission on Neuropsychobiology</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">In 2008, the U.S. Food and Drug Administration (FDA) issued an alert to health care professionals about an increased risk of suicide ideation and suicide behavior in people treated with antiepileptic drugs (AEDs). Since then, a number of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_11370528" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">In 2008, the U.S. Food and Drug Administration (FDA) issued an alert to health care professionals about an increased risk of suicide ideation and suicide behavior in people treated with antiepileptic drugs (AEDs). Since then, a number of retrospective cohort and case-control studies have been published that are trying to address this issue, but gathered results are contradictory. This report represents an expert consensus statement developed by an ad hoc task force of the Commission on Neuropsychobiology of the International League Against Epilepsy (ILAE). Although some (but not all) AEDs can be associated with treatment-emergent psychiatric problems that can lead to suicidal ideation and behavior, the actual suicidal risk is yet to be established, but it seems to be very low. The risk of stopping AEDs or refusing to start AEDs is significantly worse and can actually result in serious harm including death to the patient. Suicidality in epilepsy is multifactorial, and different variables are operant. Clinicians should investigate the existence of such risk factors and adopt appropriate screening instruments. If necessary, patients should be referred for a psychiatric evaluation, but AED treatment should not be withheld, even in patients with positive suicidal risks. When starting an AED or switching from one to other AEDs, patients should be advised to report to their treating physician any change in mood and suicidal ideation. Data on treatment-emergent psychiatric adverse events need to be collected, in addition to general safety information, during controlled studies in order to have meaningful information for patients and their relatives when a new drug is marketed.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11370528" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="221b4343a6c9da15adb1a53e7fc29cb9" rel="nofollow" data-download="{"attachment_id":46746279,"asset_id":11370528,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46746279/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="27638894" href="https://sgul.academia.edu/MarcoMula">Marco Mula</a><script data-card-contents-for-user="27638894" type="text/json">{"id":27638894,"first_name":"Marco","last_name":"Mula","domain_name":"sgul","page_name":"MarcoMula","display_name":"Marco Mula","profile_url":"https://sgul.academia.edu/MarcoMula?f_ri=7648","photo":"https://0.academia-photos.com/27638894/8051312/35119280/s65_marco.mula.jpg"}</script></span></span></li><li class="js-paper-rank-work_11370528 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="11370528"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 11370528, container: ".js-paper-rank-work_11370528", }); 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$(".js-view-count[data-work-id=11370528]").text(description); $(".js-view-count-work_11370528").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_11370528").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="11370528"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="3217" rel="nofollow" href="https://www.academia.edu/Documents/in/Depression">Depression</a>, <script data-card-contents-for-ri="3217" type="text/json">{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="8981" rel="nofollow" href="https://www.academia.edu/Documents/in/Suicide">Suicide</a>, <script data-card-contents-for-ri="8981" type="text/json">{"id":8981,"name":"Suicide","url":"https://www.academia.edu/Documents/in/Suicide?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="138569" rel="nofollow" href="https://www.academia.edu/Documents/in/Advisory_Committees">Advisory Committees</a><script data-card-contents-for-ri="138569" type="text/json">{"id":138569,"name":"Advisory Committees","url":"https://www.academia.edu/Documents/in/Advisory_Committees?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=11370528]'), work: {"id":11370528,"title":"Antiepileptic drugs and suicidality: An expert consensus statement from the Task Force on Therapeutic strategies of the ILAE Commission on Neuropsychobiology","created_at":"2015-03-11T05:54:49.198-07:00","url":"https://www.academia.edu/11370528/Antiepileptic_drugs_and_suicidality_An_expert_consensus_statement_from_the_Task_Force_on_Therapeutic_strategies_of_the_ILAE_Commission_on_Neuropsychobiology?f_ri=7648","dom_id":"work_11370528","summary":"In 2008, the U.S. Food and Drug Administration (FDA) issued an alert to health care professionals about an increased risk of suicide ideation and suicide behavior in people treated with antiepileptic drugs (AEDs). Since then, a number of retrospective cohort and case-control studies have been published that are trying to address this issue, but gathered results are contradictory. This report represents an expert consensus statement developed by an ad hoc task force of the Commission on Neuropsychobiology of the International League Against Epilepsy (ILAE). Although some (but not all) AEDs can be associated with treatment-emergent psychiatric problems that can lead to suicidal ideation and behavior, the actual suicidal risk is yet to be established, but it seems to be very low. The risk of stopping AEDs or refusing to start AEDs is significantly worse and can actually result in serious harm including death to the patient. Suicidality in epilepsy is multifactorial, and different variables are operant. Clinicians should investigate the existence of such risk factors and adopt appropriate screening instruments. If necessary, patients should be referred for a psychiatric evaluation, but AED treatment should not be withheld, even in patients with positive suicidal risks. When starting an AED or switching from one to other AEDs, patients should be advised to report to their treating physician any change in mood and suicidal ideation. Data on treatment-emergent psychiatric adverse events need to be collected, in addition to general safety information, during controlled studies in order to have meaningful information for patients and their relatives when a new drug is marketed.","downloadable_attachments":[{"id":46746279,"asset_id":11370528,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":27638894,"first_name":"Marco","last_name":"Mula","domain_name":"sgul","page_name":"MarcoMula","display_name":"Marco Mula","profile_url":"https://sgul.academia.edu/MarcoMula?f_ri=7648","photo":"https://0.academia-photos.com/27638894/8051312/35119280/s65_marco.mula.jpg"}],"research_interests":[{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":8981,"name":"Suicide","url":"https://www.academia.edu/Documents/in/Suicide?f_ri=7648","nofollow":true},{"id":138569,"name":"Advisory Committees","url":"https://www.academia.edu/Documents/in/Advisory_Committees?f_ri=7648","nofollow":true},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=7648"},{"id":228487,"name":"Epilepsia","url":"https://www.academia.edu/Documents/in/Epilepsia?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":378819,"name":"Suicidal Ideation","url":"https://www.academia.edu/Documents/in/Suicidal_Ideation?f_ri=7648"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=7648"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_12925819" data-work_id="12925819" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/12925819/Proposal_for_a_Multicenter_Study_on_Epilepsy_and_Learning_Disorders_in_Children">Proposal for a Multicenter Study on Epilepsy and Learning Disorders in Children</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/12925819" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="942aa9cd1f2f65798c19e83f99f91506" rel="nofollow" data-download="{"attachment_id":45843867,"asset_id":12925819,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45843867/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32098432" href="https://independent.academia.edu/MaurizioElia">Maurizio Elia</a><script data-card-contents-for-user="32098432" type="text/json">{"id":32098432,"first_name":"Maurizio","last_name":"Elia","domain_name":"independent","page_name":"MaurizioElia","display_name":"Maurizio Elia","profile_url":"https://independent.academia.edu/MaurizioElia?f_ri=7648","photo":"https://0.academia-photos.com/32098432/169485023/159459186/s65_maurizio.elia.jpeg"}</script></span></span></li><li class="js-paper-rank-work_12925819 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="12925819"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 12925819, container: ".js-paper-rank-work_12925819", }); });</script></li><li class="js-percentile-work_12925819 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12925819; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_12925819"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_12925819 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="12925819"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12925819; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12925819]").text(description); $(".js-view-count-work_12925819").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_12925819").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="12925819"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2066" rel="nofollow" href="https://www.academia.edu/Documents/in/Research_Design">Research Design</a>, <script data-card-contents-for-ri="2066" type="text/json">{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="28973" rel="nofollow" href="https://www.academia.edu/Documents/in/Comorbidity">Comorbidity</a>, <script data-card-contents-for-ri="28973" type="text/json">{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="45213" rel="nofollow" href="https://www.academia.edu/Documents/in/Italy">Italy</a><script data-card-contents-for-ri="45213" type="text/json">{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=12925819]'), work: {"id":12925819,"title":"Proposal for a Multicenter Study on Epilepsy and Learning Disorders in Children","created_at":"2015-06-11T07:10:08.311-07:00","url":"https://www.academia.edu/12925819/Proposal_for_a_Multicenter_Study_on_Epilepsy_and_Learning_Disorders_in_Children?f_ri=7648","dom_id":"work_12925819","summary":null,"downloadable_attachments":[{"id":45843867,"asset_id":12925819,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32098432,"first_name":"Maurizio","last_name":"Elia","domain_name":"independent","page_name":"MaurizioElia","display_name":"Maurizio Elia","profile_url":"https://independent.academia.edu/MaurizioElia?f_ri=7648","photo":"https://0.academia-photos.com/32098432/169485023/159459186/s65_maurizio.elia.jpeg"}],"research_interests":[{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=7648","nofollow":true},{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy?f_ri=7648","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=7648"},{"id":228487,"name":"Epilepsia","url":"https://www.academia.edu/Documents/in/Epilepsia?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=7648"},{"id":452593,"name":"Learning Disorders","url":"https://www.academia.edu/Documents/in/Learning_Disorders?f_ri=7648"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=7648"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=7648"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14303217" data-work_id="14303217" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14303217/A_unified_approach_for_detection_of_induced_epileptic_seizures_in_rats_using_ECoG_signals">A unified approach for detection of induced epileptic seizures in rats using ECoG signals</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objective: Epileptic seizure detection is a key step for epilepsy assessment. In this work, using the pentylenetetrazole (PTZ) model, seizures were induced in rats, and ECoG signals in interictal, preictal, ictal, and postictal periods... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14303217" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objective: Epileptic seizure detection is a key step for epilepsy assessment. In this work, using the pentylenetetrazole (PTZ) model, seizures were induced in rats, and ECoG signals in interictal, preictal, ictal, and postictal periods were recorded. The recorded ECoG signals were then analyzed to detect epileptic seizures in the epileptic rats. Methods: Two different approaches were considered in this work: thresholding and classification. In the thresholding approach, a feature is calculated in consecutive windows, and the resulted index is tracked over time and compared with a threshold. The moment the index crosses the threshold is considered as the moment of seizure onset. In the classification approach, features are extracted from before, during, and after ictal periods and statistically analyzed. Statistical characteristics of some features have a significant difference among these periods, thus resulting in epileptic seizure detection. Results: Several features were examined in the thresholding approach. Nonlinear energy and coastline features were successful in epileptic seizure detection. The best result was achieved by the coastline feature, which led to a mean of a 2-second delay in its correct detections. In the classification approach, the best result was achieved using the fuzzy similarity index that led to P value b 0.001. Conclusion: This study showed that variance-based features were more appropriate for tracking abrupt changes in ECoG signals. Therefore, these features perform better in seizure onset estimation, whereas nonlinear features or indices, which are based on dynamical systems, can better track the transition of neural system to ictal period. Significance: This paper presents examination of different features and indices for detection of induced epileptic seizures from rat's ECoG signals.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14303217" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1047108dd56aad59c9015e5b453d91b8" rel="nofollow" data-download="{"attachment_id":44341626,"asset_id":14303217,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44341626/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33260888" href="https://independent.academia.edu/MohammadNiknazar">Mohammad Niknazar</a><script data-card-contents-for-user="33260888" type="text/json">{"id":33260888,"first_name":"Mohammad","last_name":"Niknazar","domain_name":"independent","page_name":"MohammadNiknazar","display_name":"Mohammad Niknazar","profile_url":"https://independent.academia.edu/MohammadNiknazar?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14303217 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14303217"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14303217, container: ".js-paper-rank-work_14303217", }); });</script></li><li class="js-percentile-work_14303217 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14303217; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_14303217"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_14303217 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="14303217"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14303217; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14303217]").text(description); $(".js-view-count-work_14303217").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14303217").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14303217"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="428" rel="nofollow" href="https://www.academia.edu/Documents/in/Algorithms">Algorithms</a>, <script data-card-contents-for-ri="428" type="text/json">{"id":428,"name":"Algorithms","url":"https://www.academia.edu/Documents/in/Algorithms?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10904" rel="nofollow" href="https://www.academia.edu/Documents/in/Electroencephalography">Electroencephalography</a>, <script data-card-contents-for-ri="10904" type="text/json">{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="61474" rel="nofollow" href="https://www.academia.edu/Documents/in/Brain">Brain</a><script data-card-contents-for-ri="61474" type="text/json">{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14303217]'), work: {"id":14303217,"title":"A unified approach for detection of induced epileptic seizures in rats using ECoG signals","created_at":"2015-07-22T11:42:29.939-07:00","url":"https://www.academia.edu/14303217/A_unified_approach_for_detection_of_induced_epileptic_seizures_in_rats_using_ECoG_signals?f_ri=7648","dom_id":"work_14303217","summary":"Objective: Epileptic seizure detection is a key step for epilepsy assessment. In this work, using the pentylenetetrazole (PTZ) model, seizures were induced in rats, and ECoG signals in interictal, preictal, ictal, and postictal periods were recorded. The recorded ECoG signals were then analyzed to detect epileptic seizures in the epileptic rats. Methods: Two different approaches were considered in this work: thresholding and classification. In the thresholding approach, a feature is calculated in consecutive windows, and the resulted index is tracked over time and compared with a threshold. The moment the index crosses the threshold is considered as the moment of seizure onset. In the classification approach, features are extracted from before, during, and after ictal periods and statistically analyzed. Statistical characteristics of some features have a significant difference among these periods, thus resulting in epileptic seizure detection. Results: Several features were examined in the thresholding approach. Nonlinear energy and coastline features were successful in epileptic seizure detection. The best result was achieved by the coastline feature, which led to a mean of a 2-second delay in its correct detections. In the classification approach, the best result was achieved using the fuzzy similarity index that led to P value b 0.001. Conclusion: This study showed that variance-based features were more appropriate for tracking abrupt changes in ECoG signals. Therefore, these features perform better in seizure onset estimation, whereas nonlinear features or indices, which are based on dynamical systems, can better track the transition of neural system to ictal period. Significance: This paper presents examination of different features and indices for detection of induced epileptic seizures from rat's ECoG signals.","downloadable_attachments":[{"id":44341626,"asset_id":14303217,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33260888,"first_name":"Mohammad","last_name":"Niknazar","domain_name":"independent","page_name":"MohammadNiknazar","display_name":"Mohammad Niknazar","profile_url":"https://independent.academia.edu/MohammadNiknazar?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":428,"name":"Algorithms","url":"https://www.academia.edu/Documents/in/Algorithms?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648","nofollow":true},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=7648","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=7648"},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression?f_ri=7648"},{"id":1957847,"name":"Pentylenetetrazole","url":"https://www.academia.edu/Documents/in/Pentylenetetrazole?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14455159" data-work_id="14455159" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14455159/Stem_cell_therapy_for_treatment_of_epilepsy">Stem cell therapy for treatment of epilepsy</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Epilepsy as one of the most common neurological disorders affects more than 50 million people worldwide with a higher prevalence rate in low-income countries. Excessive electrical discharges in neurons following neural cell damage or loss... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14455159" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Epilepsy as one of the most common neurological disorders affects more than 50 million people worldwide with a higher prevalence rate in low-income countries. Excessive electrical discharges in neurons following neural cell damage or loss cause recurrent seizures. One of the most common and difficult to treat types of epilepsy is temporal lobe epilepsy (TLE) which results from hippocampal sclerosis. Nowadays, similar to other diseases, epilepsy also is a candidate for treatment with different types of stem cells. Various stem cell types were used for treatment of epilepsy in basic and experimental researches. Two major roles of stem cell therapy in epilepsy are prophylaxis against chronic epilepsy and amelioration cognitive function after the occurrence of TLE. Several animal studies have supported the use of these cells for treating drug-resistant TLE. Although stem cell therapy seems like a promising approach for treatment of epilepsy in the future however, there are some serious ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14455159" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e95fe582e99a21d367639ed64fbe626e" rel="nofollow" data-download="{"attachment_id":44135836,"asset_id":14455159,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44135836/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="16841945" href="https://independent.academia.edu/BabakArjmand">Babak Arjmand</a><script data-card-contents-for-user="16841945" type="text/json">{"id":16841945,"first_name":"Babak","last_name":"Arjmand","domain_name":"independent","page_name":"BabakArjmand","display_name":"Babak Arjmand","profile_url":"https://independent.academia.edu/BabakArjmand?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14455159 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14455159"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14455159, container: ".js-paper-rank-work_14455159", }); });</script></li><li class="js-percentile-work_14455159 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14455159; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_14455159"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_14455159 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="14455159"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14455159; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14455159]").text(description); $(".js-view-count-work_14455159").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14455159").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14455159"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="37864" rel="nofollow" href="https://www.academia.edu/Documents/in/Stem_Cell_Transplantation">Stem Cell Transplantation</a>, <script data-card-contents-for-ri="37864" type="text/json">{"id":37864,"name":"Stem Cell Transplantation","url":"https://www.academia.edu/Documents/in/Stem_Cell_Transplantation?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="57556" rel="nofollow" href="https://www.academia.edu/Documents/in/Hippocampus">Hippocampus</a>, <script data-card-contents-for-ri="57556" type="text/json">{"id":57556,"name":"Hippocampus","url":"https://www.academia.edu/Documents/in/Hippocampus?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="128608" rel="nofollow" href="https://www.academia.edu/Documents/in/Temporal_Lobe_Epilepsy">Temporal Lobe Epilepsy</a><script data-card-contents-for-ri="128608" type="text/json">{"id":128608,"name":"Temporal Lobe Epilepsy","url":"https://www.academia.edu/Documents/in/Temporal_Lobe_Epilepsy?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14455159]'), work: {"id":14455159,"title":"Stem cell therapy for treatment of epilepsy","created_at":"2015-07-28T00:14:50.244-07:00","url":"https://www.academia.edu/14455159/Stem_cell_therapy_for_treatment_of_epilepsy?f_ri=7648","dom_id":"work_14455159","summary":"Epilepsy as one of the most common neurological disorders affects more than 50 million people worldwide with a higher prevalence rate in low-income countries. Excessive electrical discharges in neurons following neural cell damage or loss cause recurrent seizures. One of the most common and difficult to treat types of epilepsy is temporal lobe epilepsy (TLE) which results from hippocampal sclerosis. Nowadays, similar to other diseases, epilepsy also is a candidate for treatment with different types of stem cells. Various stem cell types were used for treatment of epilepsy in basic and experimental researches. Two major roles of stem cell therapy in epilepsy are prophylaxis against chronic epilepsy and amelioration cognitive function after the occurrence of TLE. Several animal studies have supported the use of these cells for treating drug-resistant TLE. Although stem cell therapy seems like a promising approach for treatment of epilepsy in the future however, there are some serious ...","downloadable_attachments":[{"id":44135836,"asset_id":14455159,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":16841945,"first_name":"Babak","last_name":"Arjmand","domain_name":"independent","page_name":"BabakArjmand","display_name":"Babak Arjmand","profile_url":"https://independent.academia.edu/BabakArjmand?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":37864,"name":"Stem Cell Transplantation","url":"https://www.academia.edu/Documents/in/Stem_Cell_Transplantation?f_ri=7648","nofollow":true},{"id":57556,"name":"Hippocampus","url":"https://www.academia.edu/Documents/in/Hippocampus?f_ri=7648","nofollow":true},{"id":128608,"name":"Temporal Lobe Epilepsy","url":"https://www.academia.edu/Documents/in/Temporal_Lobe_Epilepsy?f_ri=7648","nofollow":true},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_22275552" data-work_id="22275552" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22275552/Comorbidity_of_migraine_and_epilepsy_in_a_Norwegian_community">Comorbidity of migraine and epilepsy in a Norwegian community</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background and purpose: Studies on the comorbidity of migraine and epilepsy have shown conflicting results. We wanted to explore the epidemiological association between migraine and seizure disorders in a population-based material where... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_22275552" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background and purpose: Studies on the comorbidity of migraine and epilepsy have shown conflicting results. We wanted to explore the epidemiological association between migraine and seizure disorders in a population-based material where case ascertainment was enhanced by individual specialist assessments. Methods: Information concerning migraine and seizure disorders was collected from 1793 participants in an interviewbased survey in a circumscribed community. Mixed headache, with features both of migraine without aura and tension-type headache, was excluded from further analyses because of its ambiguous character (n = 137). Thus, data from 1656 participants were included in the study. Results: The number of subjects with epilepsy was small, and a statistically significant association between migraine and the diagnosis of epilepsy was not found. There was a tendency to more active epilepsy in subjects with migraine (1.0%, 5/524), particularly for migraine with aura (1.8%, 3/168), compared with subjects without migraine (0.5%, 6/1132). Migraine was present in five of 11 subjects with active epilepsy (45%) and in four of 28 (14%) with epilepsy in remission (P = 0.09). Conclusions: An overall association between migraine and seizure disorders could not be demonstrated, but there was a tendency to more migraine in individuals with active epilepsy.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22275552" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9cdb83fb346527401c42b53445483c8e" rel="nofollow" data-download="{"attachment_id":42924739,"asset_id":22275552,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42924739/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32296957" href="https://independent.academia.edu/EylertBrodtkorb">Eylert Brodtkorb</a><script data-card-contents-for-user="32296957" type="text/json">{"id":32296957,"first_name":"Eylert","last_name":"Brodtkorb","domain_name":"independent","page_name":"EylertBrodtkorb","display_name":"Eylert Brodtkorb","profile_url":"https://independent.academia.edu/EylertBrodtkorb?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_22275552 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="22275552"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 22275552, container: ".js-paper-rank-work_22275552", }); 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$(".js-view-count[data-work-id=22275552]").text(description); $(".js-view-count-work_22275552").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_22275552").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="22275552"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="24089" rel="nofollow" href="https://www.academia.edu/Documents/in/Causality">Causality</a>, <script data-card-contents-for-ri="24089" type="text/json">{"id":24089,"name":"Causality","url":"https://www.academia.edu/Documents/in/Causality?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="28973" rel="nofollow" href="https://www.academia.edu/Documents/in/Comorbidity">Comorbidity</a><script data-card-contents-for-ri="28973" type="text/json">{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=22275552]'), work: {"id":22275552,"title":"Comorbidity of migraine and epilepsy in a Norwegian community","created_at":"2016-02-21T23:38:50.244-08:00","url":"https://www.academia.edu/22275552/Comorbidity_of_migraine_and_epilepsy_in_a_Norwegian_community?f_ri=7648","dom_id":"work_22275552","summary":"Background and purpose: Studies on the comorbidity of migraine and epilepsy have shown conflicting results. We wanted to explore the epidemiological association between migraine and seizure disorders in a population-based material where case ascertainment was enhanced by individual specialist assessments. Methods: Information concerning migraine and seizure disorders was collected from 1793 participants in an interviewbased survey in a circumscribed community. Mixed headache, with features both of migraine without aura and tension-type headache, was excluded from further analyses because of its ambiguous character (n = 137). Thus, data from 1656 participants were included in the study. Results: The number of subjects with epilepsy was small, and a statistically significant association between migraine and the diagnosis of epilepsy was not found. There was a tendency to more active epilepsy in subjects with migraine (1.0%, 5/524), particularly for migraine with aura (1.8%, 3/168), compared with subjects without migraine (0.5%, 6/1132). Migraine was present in five of 11 subjects with active epilepsy (45%) and in four of 28 (14%) with epilepsy in remission (P = 0.09). Conclusions: An overall association between migraine and seizure disorders could not be demonstrated, but there was a tendency to more migraine in individuals with active epilepsy.","downloadable_attachments":[{"id":42924739,"asset_id":22275552,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32296957,"first_name":"Eylert","last_name":"Brodtkorb","domain_name":"independent","page_name":"EylertBrodtkorb","display_name":"Eylert Brodtkorb","profile_url":"https://independent.academia.edu/EylertBrodtkorb?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=7648","nofollow":true},{"id":24089,"name":"Causality","url":"https://www.academia.edu/Documents/in/Causality?f_ri=7648","nofollow":true},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=7648","nofollow":true},{"id":51645,"name":"Norway","url":"https://www.academia.edu/Documents/in/Norway?f_ri=7648"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=7648"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=7648"},{"id":196189,"name":"Sample Size","url":"https://www.academia.edu/Documents/in/Sample_Size?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=7648"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21942052 coauthored" data-work_id="21942052" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21942052/Diffuse_cerebral_gangliocytoma_in_an_adult_with_late_onset_refractory_epilepsy">Diffuse cerebral gangliocytoma in an adult with late-onset refractory epilepsy</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21942052" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f91933522660d36d18526e98ae1408be" rel="nofollow" data-download="{"attachment_id":42667172,"asset_id":21942052,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42667172/download_file?st=MTc0MDIxODI2MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="43188552" href="https://ucl.academia.edu/AhmedToma">Ahmed Toma</a><script data-card-contents-for-user="43188552" type="text/json">{"id":43188552,"first_name":"Ahmed","last_name":"Toma","domain_name":"ucl","page_name":"AhmedToma","display_name":"Ahmed Toma","profile_url":"https://ucl.academia.edu/AhmedToma?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-21942052">+1</span><div class="hidden js-additional-users-21942052"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/BernardoRatilal">Bernardo Ratilal</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-21942052'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-21942052').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_21942052 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21942052"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21942052, container: 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Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6200" rel="nofollow" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging">Magnetic Resonance Imaging</a>, <script data-card-contents-for-ri="6200" type="text/json">{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10904" rel="nofollow" href="https://www.academia.edu/Documents/in/Electroencephalography">Electroencephalography</a><script data-card-contents-for-ri="10904" type="text/json">{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21942052]'), work: {"id":21942052,"title":"Diffuse cerebral gangliocytoma in an adult with late-onset refractory epilepsy","created_at":"2016-02-14T01:55:41.404-08:00","url":"https://www.academia.edu/21942052/Diffuse_cerebral_gangliocytoma_in_an_adult_with_late_onset_refractory_epilepsy?f_ri=7648","dom_id":"work_21942052","summary":null,"downloadable_attachments":[{"id":42667172,"asset_id":21942052,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":43188552,"first_name":"Ahmed","last_name":"Toma","domain_name":"ucl","page_name":"AhmedToma","display_name":"Ahmed Toma","profile_url":"https://ucl.academia.edu/AhmedToma?f_ri=7648","photo":"/images/s65_no_pic.png"},{"id":43206196,"first_name":"Bernardo","last_name":"Ratilal","domain_name":"independent","page_name":"BernardoRatilal","display_name":"Bernardo Ratilal","profile_url":"https://independent.academia.edu/BernardoRatilal?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=7648","nofollow":true},{"id":6200,"name":"Magnetic Resonance 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Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":501014,"name":"Ganglioneuroma","url":"https://www.academia.edu/Documents/in/Ganglioneuroma?f_ri=7648"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=7648"},{"id":1425045,"name":"Brain Neoplasms","url":"https://www.academia.edu/Documents/in/Brain_Neoplasms?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_20056963" data-work_id="20056963" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/20056963/Teachers_knowledge_about_epilepsy_and_attitudes_toward_students_with_epilepsy_Results_of_a_national_survey">Teachers’ knowledge about epilepsy and attitudes toward students with epilepsy: Results of a national survey</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The attitudes and epilepsy-related knowledge of teachers are an important component of the educational experiences of children with epilepsy. Unfortunately however, the exploration of teacher attitudes and knowledge has been extremely... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_20056963" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The attitudes and epilepsy-related knowledge of teachers are an important component of the educational experiences of children with epilepsy. Unfortunately however, the exploration of teacher attitudes and knowledge has been extremely limited in the United States. This article describes a survey-based research study of the attitudes and epilepsy-related knowledge of a randomly selected national sample of 512 elementary and middle school teachers in the United States. The questionnaire included the Scale of Attitudes Toward Persons with Epilepsy (ATPE), a summated rating scale that measures both attitudes toward persons with epilepsy and knowledge about epilepsy, as well as a demographic and teaching experience survey and several additional attitude and knowledge items developed by the researchers. The results suggest that although teachersÕ attitudes about epilepsy were generally positive, there were significant deficits in terms of general knowledge about epilepsy, its impact in educational settings, and the appropriate management of epilepsy and seizures in the classroom. Critical areas in which to focus remedial education and outreach efforts are identified.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/20056963" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c87ce43f2f5baaad340d1784f164f0e0" rel="nofollow" data-download="{"attachment_id":41161062,"asset_id":20056963,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41161062/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="41022884" href="https://independent.academia.edu/MBishop3">M Bishop</a><script data-card-contents-for-user="41022884" type="text/json">{"id":41022884,"first_name":"M","last_name":"Bishop","domain_name":"independent","page_name":"MBishop3","display_name":"M Bishop","profile_url":"https://independent.academia.edu/MBishop3?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_20056963 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="20056963"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 20056963, container: ".js-paper-rank-work_20056963", }); 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$(".js-view-count[data-work-id=20056963]").text(description); $(".js-view-count-work_20056963").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_20056963").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="20056963"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="7428" rel="nofollow" href="https://www.academia.edu/Documents/in/Health_Education">Health Education</a>, <script data-card-contents-for-ri="7428" type="text/json">{"id":7428,"name":"Health Education","url":"https://www.academia.edu/Documents/in/Health_Education?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7470" rel="nofollow" href="https://www.academia.edu/Documents/in/Quality_of_life">Quality of life</a>, <script data-card-contents-for-ri="7470" type="text/json">{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49610" rel="nofollow" href="https://www.academia.edu/Documents/in/Schools">Schools</a><script data-card-contents-for-ri="49610" type="text/json">{"id":49610,"name":"Schools","url":"https://www.academia.edu/Documents/in/Schools?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=20056963]'), work: {"id":20056963,"title":"Teachers’ knowledge about epilepsy and attitudes toward students with epilepsy: Results of a national survey","created_at":"2016-01-06T05:13:17.062-08:00","url":"https://www.academia.edu/20056963/Teachers_knowledge_about_epilepsy_and_attitudes_toward_students_with_epilepsy_Results_of_a_national_survey?f_ri=7648","dom_id":"work_20056963","summary":"The attitudes and epilepsy-related knowledge of teachers are an important component of the educational experiences of children with epilepsy. Unfortunately however, the exploration of teacher attitudes and knowledge has been extremely limited in the United States. This article describes a survey-based research study of the attitudes and epilepsy-related knowledge of a randomly selected national sample of 512 elementary and middle school teachers in the United States. The questionnaire included the Scale of Attitudes Toward Persons with Epilepsy (ATPE), a summated rating scale that measures both attitudes toward persons with epilepsy and knowledge about epilepsy, as well as a demographic and teaching experience survey and several additional attitude and knowledge items developed by the researchers. The results suggest that although teachersÕ attitudes about epilepsy were generally positive, there were significant deficits in terms of general knowledge about epilepsy, its impact in educational settings, and the appropriate management of epilepsy and seizures in the classroom. Critical areas in which to focus remedial education and outreach efforts are identified.","downloadable_attachments":[{"id":41161062,"asset_id":20056963,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":41022884,"first_name":"M","last_name":"Bishop","domain_name":"independent","page_name":"MBishop3","display_name":"M Bishop","profile_url":"https://independent.academia.edu/MBishop3?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7428,"name":"Health Education","url":"https://www.academia.edu/Documents/in/Health_Education?f_ri=7648","nofollow":true},{"id":7470,"name":"Quality of 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Multicentric Registry of Birth Defects (IPIMC)</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">A case control study on the a s s o c i a t i 0 n b e t w e e n maternal epilepsy, anticonvulsants use during pregnancy and birth defectS' ~,as carried out in the Italian Multicentric Registry of Birth ~Defeets '(IPIMC).</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/20012163" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="49f00152e9ab0a82d1b2eb9268ab2e12" rel="nofollow" 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= 20012163; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_20012163"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_20012163 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="20012163"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20012163; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20012163]").text(description); $(".js-view-count-work_20012163").attr('title', description).tooltip(); }); });</script></span><script>$(function() { 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Palate","url":"https://www.academia.edu/Documents/in/Cleft_Palate?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="45213" rel="nofollow" href="https://www.academia.edu/Documents/in/Italy">Italy</a>, <script data-card-contents-for-ri="45213" type="text/json">{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="57980" rel="nofollow" href="https://www.academia.edu/Documents/in/Congenital_Heart_Defects">Congenital Heart Defects</a><script data-card-contents-for-ri="57980" type="text/json">{"id":57980,"name":"Congenital Heart Defects","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Defects?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=20012163]'), work: {"id":20012163,"title":"Maternal epilepsy and birth defects: A 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Bertollini","profile_url":"https://independent.academia.edu/RobertoBertollini?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":9917,"name":"Cleft Palate","url":"https://www.academia.edu/Documents/in/Cleft_Palate?f_ri=7648","nofollow":true},{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy?f_ri=7648","nofollow":true},{"id":57980,"name":"Congenital Heart Defects","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Defects?f_ri=7648","nofollow":true},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=7648"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=7648"},{"id":311093,"name":"Trisomy 21","url":"https://www.academia.edu/Documents/in/Trisomy_21?f_ri=7648"},{"id":375314,"name":"Valproic Acid","url":"https://www.academia.edu/Documents/in/Valproic_Acid?f_ri=7648"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=7648"},{"id":477954,"name":"Cleft Lip","url":"https://www.academia.edu/Documents/in/Cleft_Lip?f_ri=7648"},{"id":579357,"name":"Congenital Diaphragmatic Hernia","url":"https://www.academia.edu/Documents/in/Congenital_Diaphragmatic_Hernia?f_ri=7648"},{"id":769713,"name":"Spina Bifida","url":"https://www.academia.edu/Documents/in/Spina_Bifida?f_ri=7648"},{"id":799412,"name":"Chromosome Disorders","url":"https://www.academia.edu/Documents/in/Chromosome_Disorders?f_ri=7648"},{"id":910025,"name":"Case Control Study","url":"https://www.academia.edu/Documents/in/Case_Control_Study?f_ri=7648"},{"id":1161416,"name":"Congenital abnormalities","url":"https://www.academia.edu/Documents/in/Congenital_abnormalities?f_ri=7648"},{"id":1541612,"name":"Birth Defect","url":"https://www.academia.edu/Documents/in/Birth_Defect?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_43567210" data-work_id="43567210" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/43567210/Estudo_de_caso_S%C3%ADndrome_de_West">Estudo de caso: Síndrome de West</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">O presente caso clinico pretende demonstrar a intervenção psicoterapêutica sobre um quadro infantil diagnosticado neuropediatricamente com a Síndrome de West dos 4 aos 8 anos. Complementarmente ao diagnostico neurológico, o garoto em... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_43567210" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">O presente caso clinico pretende demonstrar a intervenção psicoterapêutica sobre um quadro infantil diagnosticado neuropediatricamente com a Síndrome de West dos 4 aos 8 anos. Complementarmente ao diagnostico neurológico, o garoto em questão apresentava uma série de estereotipias e comportamentos repetitivos que apontavam para dinâmica de espectro autista. Sendo acompanhado por uma equipe multiprofissional (neuropediatra, fonoaudióloga, fisioterapeuta e Terapeuta Ocupacional) em um ambulatório de reabilitação clinica infantil, a psicoterapia tornou-se parte do tratamento pela dinâmica apresentada. A psicoterapia atuou sobre o quadro clinico principalmente por meio da ludoterapia e do acompanhamento psicoterapêutico e orientação familiar da responsável materna. A relação mãe e filho se apresentava dependente e tal dinâmica estava atuando de maneira negativa sobre o desenvolvimento da criança, acentuando o atraso no desenvolvimento neuropsicomotor. Juntamente com a orientação familiar a mãe se tornou peça fundamental para obtenção de melhorias no quadro comportamental global e independência de seu filho. A partir do referencial psicanalítico se refletirá a intervenção sobre a dinâmica mãe e filho e as possibilidades que este referencial fornece para a psicoterapia infantil.<br /><br />Palavra-chave: Síndrome de West; Relação Mãe e Filho; Intervenções Psicoterapêuticas.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/43567210" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f47e9cf4d73ec0b46cdc03a6f3a3d7d7" rel="nofollow" data-download="{"attachment_id":63873371,"asset_id":43567210,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/63873371/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="155461286" href="https://edutecno.academia.edu/ReneSchubert">Rene Schubert</a><script data-card-contents-for-user="155461286" type="text/json">{"id":155461286,"first_name":"Rene","last_name":"Schubert","domain_name":"edutecno","page_name":"ReneSchubert","display_name":"Rene Schubert","profile_url":"https://edutecno.academia.edu/ReneSchubert?f_ri=7648","photo":"https://0.academia-photos.com/155461286/43733421/34657451/s65_rene.schubert.jpeg"}</script></span></span></li><li class="js-paper-rank-work_43567210 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="43567210"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 43567210, container: ".js-paper-rank-work_43567210", }); 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$(".js-view-count[data-work-id=43567210]").text(description); $(".js-view-count-work_43567210").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_43567210").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="43567210"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="28973" rel="nofollow" href="https://www.academia.edu/Documents/in/Comorbidity">Comorbidity</a>, <script data-card-contents-for-ri="28973" type="text/json">{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="32136" rel="nofollow" href="https://www.academia.edu/Documents/in/Autonomia">Autonomia</a>, <script data-card-contents-for-ri="32136" type="text/json">{"id":32136,"name":"Autonomia","url":"https://www.academia.edu/Documents/in/Autonomia?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="92202" rel="nofollow" href="https://www.academia.edu/Documents/in/Psican%C3%A1lise">Psicanálise</a><script data-card-contents-for-ri="92202" type="text/json">{"id":92202,"name":"Psicanálise","url":"https://www.academia.edu/Documents/in/Psican%C3%A1lise?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=43567210]'), work: {"id":43567210,"title":"Estudo de caso: Síndrome de West","created_at":"2020-07-09T07:03:37.671-07:00","url":"https://www.academia.edu/43567210/Estudo_de_caso_S%C3%ADndrome_de_West?f_ri=7648","dom_id":"work_43567210","summary":" O presente caso clinico pretende demonstrar a intervenção psicoterapêutica sobre um quadro infantil diagnosticado neuropediatricamente com a Síndrome de West dos 4 aos 8 anos. Complementarmente ao diagnostico neurológico, o garoto em questão apresentava uma série de estereotipias e comportamentos repetitivos que apontavam para dinâmica de espectro autista. Sendo acompanhado por uma equipe multiprofissional (neuropediatra, fonoaudióloga, fisioterapeuta e Terapeuta Ocupacional) em um ambulatório de reabilitação clinica infantil, a psicoterapia tornou-se parte do tratamento pela dinâmica apresentada. A psicoterapia atuou sobre o quadro clinico principalmente por meio da ludoterapia e do acompanhamento psicoterapêutico e orientação familiar da responsável materna. A relação mãe e filho se apresentava dependente e tal dinâmica estava atuando de maneira negativa sobre o desenvolvimento da criança, acentuando o atraso no desenvolvimento neuropsicomotor. Juntamente com a orientação familiar a mãe se tornou peça fundamental para obtenção de melhorias no quadro comportamental global e independência de seu filho. A partir do referencial psicanalítico se refletirá a intervenção sobre a dinâmica mãe e filho e as possibilidades que este referencial fornece para a psicoterapia infantil.\n\nPalavra-chave: Síndrome de West; Relação Mãe e Filho; Intervenções Psicoterapêuticas.\n","downloadable_attachments":[{"id":63873371,"asset_id":43567210,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":155461286,"first_name":"Rene","last_name":"Schubert","domain_name":"edutecno","page_name":"ReneSchubert","display_name":"Rene Schubert","profile_url":"https://edutecno.academia.edu/ReneSchubert?f_ri=7648","photo":"https://0.academia-photos.com/155461286/43733421/34657451/s65_rene.schubert.jpeg"}],"research_interests":[{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=7648","nofollow":true},{"id":32136,"name":"Autonomia","url":"https://www.academia.edu/Documents/in/Autonomia?f_ri=7648","nofollow":true},{"id":92202,"name":"Psicanálise","url":"https://www.academia.edu/Documents/in/Psican%C3%A1lise?f_ri=7648","nofollow":true},{"id":98816,"name":"Psychiatric Comorbidity","url":"https://www.academia.edu/Documents/in/Psychiatric_Comorbidity?f_ri=7648"},{"id":258050,"name":"Autismo","url":"https://www.academia.edu/Documents/in/Autismo?f_ri=7648"},{"id":1110735,"name":"Neuropediatria","url":"https://www.academia.edu/Documents/in/Neuropediatria?f_ri=7648"},{"id":1290069,"name":"Ludoterapia","url":"https://www.academia.edu/Documents/in/Ludoterapia?f_ri=7648"},{"id":1445134,"name":"Dependência","url":"https://www.academia.edu/Documents/in/Depend%C3%AAncia?f_ri=7648"},{"id":2936200,"name":"relação mãe-filho","url":"https://www.academia.edu/Documents/in/rela%C3%A7%C3%A3o_m%C3%A3e-filho?f_ri=7648"},{"id":3640870,"name":"René Schubert ","url":"https://www.academia.edu/Documents/in/Ren%C3%A9_Schubert?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_80067291" data-work_id="80067291" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/80067291/A_Novel_Whole_Exon_Deletion_in_WWOX_Gene_Causes_Early_Epilepsy_Intellectual_Disability_and_Optic_Atrophy">A Novel Whole Exon Deletion in WWOX Gene Causes Early Epilepsy, Intellectual Disability and Optic Atrophy</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Recent studies have implicated the WW domaincontaining oxidoreductase encoding gene (WWOX) in a severe form of autosomal recessive neurological disorder. This condition showed an overlapping spectrum of clinical features including... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_80067291" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Recent studies have implicated the WW domaincontaining oxidoreductase encoding gene (WWOX) in a severe form of autosomal recessive neurological disorder. This condition showed an overlapping spectrum of clinical features including spinocerebellar ataxia associated with generalized seizures and delayed psychomotor development to growth retardation, spasticity, and microcephaly. We evaluated a child from a consanguineous Emirati family that presented at birth with growth retardation, microcephaly, epileptic seizures, and later developed spasticity and delayed psychomotor development. Screening for deletions and duplications using wholechromosomal microarray analysis identified a novel homozygous microdeletion encompassing exon 5 of the WWOX gene. Analysis of parental DNA indicated that this deletion was inherited from both parents and lies within a large region of homozygosity. Sanger sequencing of the cDNA showed that the deletion resulted in exon 5 skipping leading to a frameshift and creating a premature stop codon at amino acid position 212. Quantification of mRNA revealed striking low level of WWOX expression in the child and moderate level of expression in the mother compared to a healthy control. To the best of our knowledge, this is the first homozygous germline structural variation in WWOX gene resulting in truncated transcripts that were presumably subject to NMD pathway. Our findings extend the clinical and genetic spectrum of WWOX mutations and support a crucial role of this gene in neurological development.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/80067291" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="51c07ba2a498e0a78abf5dd0cf11cdae" rel="nofollow" data-download="{"attachment_id":86572284,"asset_id":80067291,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/86572284/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="24134488" href="https://independent.academia.edu/AlshamsiA">Aisha Alshamsi</a><script data-card-contents-for-user="24134488" type="text/json">{"id":24134488,"first_name":"Aisha","last_name":"Alshamsi","domain_name":"independent","page_name":"AlshamsiA","display_name":"Aisha Alshamsi","profile_url":"https://independent.academia.edu/AlshamsiA?f_ri=7648","photo":"https://0.academia-photos.com/24134488/14958297/15710615/s65_aisha.alshamsi.jpg"}</script></span></span></li><li class="js-paper-rank-work_80067291 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="80067291"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 80067291, container: ".js-paper-rank-work_80067291", }); });</script></li><li class="js-percentile-work_80067291 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 80067291; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_80067291"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_80067291 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="80067291"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80067291; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=80067291]").text(description); $(".js-view-count-work_80067291").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_80067291").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="80067291"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="237" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7710" rel="nofollow" href="https://www.academia.edu/Documents/in/Biology">Biology</a>, <script data-card-contents-for-ri="7710" type="text/json">{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7953" rel="nofollow" href="https://www.academia.edu/Documents/in/Molecular_Neuroscience">Molecular Neuroscience</a><script data-card-contents-for-ri="7953" type="text/json">{"id":7953,"name":"Molecular Neuroscience","url":"https://www.academia.edu/Documents/in/Molecular_Neuroscience?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=80067291]'), work: {"id":80067291,"title":"A Novel Whole Exon Deletion in WWOX Gene Causes Early Epilepsy, Intellectual Disability and Optic Atrophy","created_at":"2022-05-27T12:14:47.410-07:00","url":"https://www.academia.edu/80067291/A_Novel_Whole_Exon_Deletion_in_WWOX_Gene_Causes_Early_Epilepsy_Intellectual_Disability_and_Optic_Atrophy?f_ri=7648","dom_id":"work_80067291","summary":"Recent studies have implicated the WW domaincontaining oxidoreductase encoding gene (WWOX) in a severe form of autosomal recessive neurological disorder. This condition showed an overlapping spectrum of clinical features including spinocerebellar ataxia associated with generalized seizures and delayed psychomotor development to growth retardation, spasticity, and microcephaly. We evaluated a child from a consanguineous Emirati family that presented at birth with growth retardation, microcephaly, epileptic seizures, and later developed spasticity and delayed psychomotor development. Screening for deletions and duplications using wholechromosomal microarray analysis identified a novel homozygous microdeletion encompassing exon 5 of the WWOX gene. Analysis of parental DNA indicated that this deletion was inherited from both parents and lies within a large region of homozygosity. Sanger sequencing of the cDNA showed that the deletion resulted in exon 5 skipping leading to a frameshift and creating a premature stop codon at amino acid position 212. Quantification of mRNA revealed striking low level of WWOX expression in the child and moderate level of expression in the mother compared to a healthy control. To the best of our knowledge, this is the first homozygous germline structural variation in WWOX gene resulting in truncated transcripts that were presumably subject to NMD pathway. Our findings extend the clinical and genetic spectrum of WWOX mutations and support a crucial role of this gene in neurological development.","downloadable_attachments":[{"id":86572284,"asset_id":80067291,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":24134488,"first_name":"Aisha","last_name":"Alshamsi","domain_name":"independent","page_name":"AlshamsiA","display_name":"Aisha Alshamsi","profile_url":"https://independent.academia.edu/AlshamsiA?f_ri=7648","photo":"https://0.academia-photos.com/24134488/14958297/15710615/s65_aisha.alshamsi.jpg"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=7648","nofollow":true},{"id":7953,"name":"Molecular Neuroscience","url":"https://www.academia.edu/Documents/in/Molecular_Neuroscience?f_ri=7648","nofollow":true},{"id":23868,"name":"Intellectual Disability","url":"https://www.academia.edu/Documents/in/Intellectual_Disability?f_ri=7648"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=7648"},{"id":112338,"name":"Oxidoreductases","url":"https://www.academia.edu/Documents/in/Oxidoreductases?f_ri=7648"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=7648"},{"id":1225171,"name":"Syndrome","url":"https://www.academia.edu/Documents/in/Syndrome?f_ri=7648"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=7648"},{"id":2442320,"name":"Optic Atrophy","url":"https://www.academia.edu/Documents/in/Optic_Atrophy?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_73589393" data-work_id="73589393" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/73589393/Alternating_hemiplegia_in_a_child_misdiagnosed_as_intractable_epilepsy_successfully_treated_with_aripiprazole_a_case_report">Alternating hemiplegia in a child misdiagnosed as intractable epilepsy successfully treated with aripiprazole: a case report</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Alternating hemiplegia of children is a rare neurological disorder that in its characteristic form has few differential diagnosis. The diagnosis of intractable seizures is difficult to avoid for physicians not aware of the disease. To... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_73589393" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Alternating hemiplegia of children is a rare neurological disorder that in its characteristic form has few differential diagnosis. The diagnosis of intractable seizures is difficult to avoid for physicians not aware of the disease. To describe the clinical characteristics of Alternating Hemiplegia of Childhood (AHC), and response to various drugs A Ghanaian child with AHC was followed up for three years at the Neurology Clinic, Korle Bu Teaching Hospital, Accra. Her characteristics including EEG and MRI findings were documented. She was severely unsuccessfully treated as an epileptic. Further clinical re-evaluation provided clues to the diagnosis of alternating hemiplegia of childhood. The child, a female patient, was seen within the first week of life. The initial complaints were abnormal eye movements, and subsequently recurrent hemiplegic episodes, that started at age two and lasted hours to days. Attacks occurred at a frequency of about three per month and lasted from several ho...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73589393" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ce7497881f74f99668139d8109a6a46c" rel="nofollow" data-download="{"attachment_id":82052662,"asset_id":73589393,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/82052662/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="86879661" href="https://independent.academia.edu/EBadoe">E. Badoe</a><script data-card-contents-for-user="86879661" type="text/json">{"id":86879661,"first_name":"E.","last_name":"Badoe","domain_name":"independent","page_name":"EBadoe","display_name":"E. Badoe","profile_url":"https://independent.academia.edu/EBadoe?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_73589393 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="73589393"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 73589393, container: ".js-paper-rank-work_73589393", }); });</script></li><li class="js-percentile-work_73589393 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73589393; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_73589393"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_73589393 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="73589393"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73589393; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73589393]").text(description); $(".js-view-count-work_73589393").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_73589393").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="73589393"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6200" rel="nofollow" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging">Magnetic Resonance Imaging</a>, <script data-card-contents-for-ri="6200" type="text/json">{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10904" rel="nofollow" href="https://www.academia.edu/Documents/in/Electroencephalography">Electroencephalography</a>, <script data-card-contents-for-ri="10904" type="text/json">{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a><script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=73589393]'), work: {"id":73589393,"title":"Alternating hemiplegia in a child misdiagnosed as intractable epilepsy successfully treated with aripiprazole: a case report","created_at":"2022-03-12T02:23:52.209-08:00","url":"https://www.academia.edu/73589393/Alternating_hemiplegia_in_a_child_misdiagnosed_as_intractable_epilepsy_successfully_treated_with_aripiprazole_a_case_report?f_ri=7648","dom_id":"work_73589393","summary":"Alternating hemiplegia of children is a rare neurological disorder that in its characteristic form has few differential diagnosis. The diagnosis of intractable seizures is difficult to avoid for physicians not aware of the disease. To describe the clinical characteristics of Alternating Hemiplegia of Childhood (AHC), and response to various drugs A Ghanaian child with AHC was followed up for three years at the Neurology Clinic, Korle Bu Teaching Hospital, Accra. Her characteristics including EEG and MRI findings were documented. She was severely unsuccessfully treated as an epileptic. Further clinical re-evaluation provided clues to the diagnosis of alternating hemiplegia of childhood. The child, a female patient, was seen within the first week of life. The initial complaints were abnormal eye movements, and subsequently recurrent hemiplegic episodes, that started at age two and lasted hours to days. Attacks occurred at a frequency of about three per month and lasted from several ho...","downloadable_attachments":[{"id":82052662,"asset_id":73589393,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":86879661,"first_name":"E.","last_name":"Badoe","domain_name":"independent","page_name":"EBadoe","display_name":"E. Badoe","profile_url":"https://independent.academia.edu/EBadoe?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=7648","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=7648"},{"id":119238,"name":"Hemiplegia","url":"https://www.academia.edu/Documents/in/Hemiplegia?f_ri=7648"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=7648"},{"id":195950,"name":"Quinolones","url":"https://www.academia.edu/Documents/in/Quinolones?f_ri=7648"},{"id":306862,"name":"Abnormal","url":"https://www.academia.edu/Documents/in/Abnormal?f_ri=7648"},{"id":643228,"name":"Ataxia","url":"https://www.academia.edu/Documents/in/Ataxia?f_ri=7648"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=7648"},{"id":2795557,"name":"Antipsychotic agents","url":"https://www.academia.edu/Documents/in/Antipsychotic_agents?f_ri=7648"},{"id":4071382,"name":"Diagnostic errors","url":"https://www.academia.edu/Documents/in/Diagnostic_errors?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_57119850" data-work_id="57119850" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/57119850/Recurrent_copy_number_variations_as_risk_factors_for_neurodevelopmental_disorders_critical_overview_and_analysis_of_clinical_implications">Recurrent copy number variations as risk factors for neurodevelopmental disorders: critical overview and analysis of clinical implications</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Neurodevelopmental disorders (NDs) encompass a spectrum of neuropsychiatric manifestations. Chromosomal regions 1q21.1, 3q29, 15q11.2, 15q13.3, 16p11.2, 16p13.1 and 22q11 harbour rare but recurrent CNVs that have been uncovered as being... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_57119850" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Neurodevelopmental disorders (NDs) encompass a spectrum of neuropsychiatric manifestations. Chromosomal regions 1q21.1, 3q29, 15q11.2, 15q13.3, 16p11.2, 16p13.1 and 22q11 harbour rare but recurrent CNVs that have been uncovered as being important risk factors for several of these disorders. These rearrangements may underlie a broad phenotypical spectrum, ranging from normal development, to learning problems, intellectual disability (ID), epilepsy and psychiatric diseases, such as autism spectrum disorders (ASDs) and schizophrenia (SZ). The highly increased risk of developing neurodevelopmental phenotypes associated with some of these CNVs makes them an unavoidable element in the clinical context in paediatrics, neurology and psychiatry. However, and although finding these risk loci has been the goal of neuropsychiatric genetics for many years, the translation of this recent knowledge into clinical practice has not been trivial. In this article, we will: (1) review the state of the a...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/57119850" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d79dbb4c55cc17865ef77991dfef2385" rel="nofollow" data-download="{"attachment_id":72171547,"asset_id":57119850,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/72171547/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35115734" href="https://independent.academia.edu/HelenFryssira">Helen Fryssira</a><script data-card-contents-for-user="35115734" type="text/json">{"id":35115734,"first_name":"Helen","last_name":"Fryssira","domain_name":"independent","page_name":"HelenFryssira","display_name":"Helen Fryssira","profile_url":"https://independent.academia.edu/HelenFryssira?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_57119850 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="57119850"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 57119850, container: ".js-paper-rank-work_57119850", }); });</script></li><li class="js-percentile-work_57119850 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 57119850; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_57119850"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_57119850 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="57119850"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 57119850; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=57119850]").text(description); $(".js-view-count-work_57119850").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_57119850").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="57119850"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="156" rel="nofollow" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2568" rel="nofollow" href="https://www.academia.edu/Documents/in/Medical_Genetics">Medical Genetics</a>, <script data-card-contents-for-ri="2568" type="text/json">{"id":2568,"name":"Medical Genetics","url":"https://www.academia.edu/Documents/in/Medical_Genetics?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3227" rel="nofollow" href="https://www.academia.edu/Documents/in/Schizophrenia">Schizophrenia</a>, <script data-card-contents-for-ri="3227" type="text/json">{"id":3227,"name":"Schizophrenia","url":"https://www.academia.edu/Documents/in/Schizophrenia?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a><script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=57119850]'), work: {"id":57119850,"title":"Recurrent copy number variations as risk factors for neurodevelopmental disorders: critical overview and analysis of clinical implications","created_at":"2021-10-11T01:18:21.891-07:00","url":"https://www.academia.edu/57119850/Recurrent_copy_number_variations_as_risk_factors_for_neurodevelopmental_disorders_critical_overview_and_analysis_of_clinical_implications?f_ri=7648","dom_id":"work_57119850","summary":"Neurodevelopmental disorders (NDs) encompass a spectrum of neuropsychiatric manifestations. Chromosomal regions 1q21.1, 3q29, 15q11.2, 15q13.3, 16p11.2, 16p13.1 and 22q11 harbour rare but recurrent CNVs that have been uncovered as being important risk factors for several of these disorders. These rearrangements may underlie a broad phenotypical spectrum, ranging from normal development, to learning problems, intellectual disability (ID), epilepsy and psychiatric diseases, such as autism spectrum disorders (ASDs) and schizophrenia (SZ). The highly increased risk of developing neurodevelopmental phenotypes associated with some of these CNVs makes them an unavoidable element in the clinical context in paediatrics, neurology and psychiatry. However, and although finding these risk loci has been the goal of neuropsychiatric genetics for many years, the translation of this recent knowledge into clinical practice has not been trivial. In this article, we will: (1) review the state of the a...","downloadable_attachments":[{"id":72171547,"asset_id":57119850,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35115734,"first_name":"Helen","last_name":"Fryssira","domain_name":"independent","page_name":"HelenFryssira","display_name":"Helen Fryssira","profile_url":"https://independent.academia.edu/HelenFryssira?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=7648","nofollow":true},{"id":2568,"name":"Medical Genetics","url":"https://www.academia.edu/Documents/in/Medical_Genetics?f_ri=7648","nofollow":true},{"id":3227,"name":"Schizophrenia","url":"https://www.academia.edu/Documents/in/Schizophrenia?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=7648"},{"id":47904,"name":"Genetic counseling","url":"https://www.academia.edu/Documents/in/Genetic_counseling?f_ri=7648"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=7648"},{"id":103992,"name":"Clinical Genetics","url":"https://www.academia.edu/Documents/in/Clinical_Genetics?f_ri=7648"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=7648"},{"id":234882,"name":"Autism Spectrum Disorder","url":"https://www.academia.edu/Documents/in/Autism_Spectrum_Disorder?f_ri=7648"},{"id":243334,"name":"Neurodevelopmental Disorders","url":"https://www.academia.edu/Documents/in/Neurodevelopmental_Disorders?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":554768,"name":"Prenatal Diagnosis","url":"https://www.academia.edu/Documents/in/Prenatal_Diagnosis?f_ri=7648"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=7648"},{"id":839311,"name":"Induced Pluripotent Stem Cells","url":"https://www.academia.edu/Documents/in/Induced_Pluripotent_Stem_Cells?f_ri=7648"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_5803845" data-work_id="5803845" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/5803845/Movement_related_activity_in_the_high_gamma_range_of_the_human_EEG">Movement related activity in the high gamma range of the human EEG</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/5803845" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d48aa560d2b805586a61f095993b0c38" rel="nofollow" data-download="{"attachment_id":49132725,"asset_id":5803845,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49132725/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="8508157" href="https://unibas.academia.edu/isabellamutschler">Isabella Mutschler Collins</a><script data-card-contents-for-user="8508157" type="text/json">{"id":8508157,"first_name":"Isabella","last_name":"Mutschler Collins","domain_name":"unibas","page_name":"isabellamutschler","display_name":"Isabella Mutschler Collins","profile_url":"https://unibas.academia.edu/isabellamutschler?f_ri=7648","photo":"https://0.academia-photos.com/8508157/2859594/3339574/s65_isabella.mutschler.jpg"}</script></span></span></li><li class="js-paper-rank-work_5803845 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="5803845"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 5803845, container: ".js-paper-rank-work_5803845", }); });</script></li><li class="js-percentile-work_5803845 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 5803845; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_5803845"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_5803845 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="5803845"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5803845; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=5803845]").text(description); $(".js-view-count-work_5803845").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_5803845").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="5803845"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10904" rel="nofollow" href="https://www.academia.edu/Documents/in/Electroencephalography">Electroencephalography</a>, <script data-card-contents-for-ri="10904" type="text/json">{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="52176" rel="nofollow" href="https://www.academia.edu/Documents/in/Brain_Mapping">Brain Mapping</a>, <script data-card-contents-for-ri="52176" type="text/json">{"id":52176,"name":"Brain Mapping","url":"https://www.academia.edu/Documents/in/Brain_Mapping?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="61474" rel="nofollow" href="https://www.academia.edu/Documents/in/Brain">Brain</a><script data-card-contents-for-ri="61474" type="text/json">{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=5803845]'), work: {"id":5803845,"title":"Movement related activity in the high gamma range of the human EEG","created_at":"2014-01-22T06:42:55.278-08:00","url":"https://www.academia.edu/5803845/Movement_related_activity_in_the_high_gamma_range_of_the_human_EEG?f_ri=7648","dom_id":"work_5803845","summary":null,"downloadable_attachments":[{"id":49132725,"asset_id":5803845,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":8508157,"first_name":"Isabella","last_name":"Mutschler Collins","domain_name":"unibas","page_name":"isabellamutschler","display_name":"Isabella Mutschler Collins","profile_url":"https://unibas.academia.edu/isabellamutschler?f_ri=7648","photo":"https://0.academia-photos.com/8508157/2859594/3339574/s65_isabella.mutschler.jpg"}],"research_interests":[{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648","nofollow":true},{"id":52176,"name":"Brain Mapping","url":"https://www.academia.edu/Documents/in/Brain_Mapping?f_ri=7648","nofollow":true},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=7648","nofollow":true},{"id":84745,"name":"Movement","url":"https://www.academia.edu/Documents/in/Movement?f_ri=7648"},{"id":103260,"name":"Neuroimage","url":"https://www.academia.edu/Documents/in/Neuroimage?f_ri=7648"},{"id":174800,"name":"Gamma Band","url":"https://www.academia.edu/Documents/in/Gamma_Band?f_ri=7648"},{"id":187814,"name":"Electroencephalogram","url":"https://www.academia.edu/Documents/in/Electroencephalogram?f_ri=7648"},{"id":337457,"name":"Supplementary Motor Area","url":"https://www.academia.edu/Documents/in/Supplementary_Motor_Area?f_ri=7648"},{"id":473567,"name":"Neuronal Activity","url":"https://www.academia.edu/Documents/in/Neuronal_Activity?f_ri=7648"},{"id":979686,"name":"Human Subjects","url":"https://www.academia.edu/Documents/in/Human_Subjects?f_ri=7648"},{"id":1142759,"name":"Healthy Subjects","url":"https://www.academia.edu/Documents/in/Healthy_Subjects?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_11370606" data-work_id="11370606" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11370606/Validation_of_the_Italian_version_of_the_Neurological_Disorders_Depression_Inventory_for_Epilepsy_NDDI_E_">Validation of the Italian version of the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E)</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) was developed for the rapid detection of a major depressive episode in people with epilepsy. It has been proven to be a user-friendly screening instrument. This study... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_11370606" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) was developed for the rapid detection of a major depressive episode in people with epilepsy. It has been proven to be a user-friendly screening instrument. This study describes the development, validation, and psychometric properties of the Italian version of the NDDI-E. A consecutive sample of 120 outpatients with epilepsy has been assessed using the M.I.N.I. Plus version 5.0.0 and the NDDI-E. All patients had no major difficulties in understanding or answering the questions of the Italian version. Cronbach's alpha coefficient was 0.851. Receiver operating characteristic analysis showed an area under the curve of 0.943 (CI95% = 0.902-0.985; SE 0.021; p b 0.001), a cut off score of 13, a sensitivity of 86.2%, a specificity of 89%, a positive predictive value of 71.4%, and a negative predictive value of 95.3%.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11370606" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="39303c4326019d7fb0afd09c4bc034c5" rel="nofollow" data-download="{"attachment_id":46746270,"asset_id":11370606,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46746270/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="27638894" href="https://sgul.academia.edu/MarcoMula">Marco Mula</a><script data-card-contents-for-user="27638894" type="text/json">{"id":27638894,"first_name":"Marco","last_name":"Mula","domain_name":"sgul","page_name":"MarcoMula","display_name":"Marco Mula","profile_url":"https://sgul.academia.edu/MarcoMula?f_ri=7648","photo":"https://0.academia-photos.com/27638894/8051312/35119280/s65_marco.mula.jpg"}</script></span></span></li><li class="js-paper-rank-work_11370606 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="11370606"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 11370606, container: ".js-paper-rank-work_11370606", }); });</script></li><li class="js-percentile-work_11370606 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 11370606; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_11370606"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_11370606 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="11370606"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 11370606; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=11370606]").text(description); $(".js-view-count-work_11370606").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_11370606").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="11370606"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2599" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychometrics">Psychometrics</a>, <script data-card-contents-for-ri="2599" type="text/json">{"id":2599,"name":"Psychometrics","url":"https://www.academia.edu/Documents/in/Psychometrics?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3217" rel="nofollow" href="https://www.academia.edu/Documents/in/Depression">Depression</a>, <script data-card-contents-for-ri="3217" type="text/json">{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="44355" rel="nofollow" href="https://www.academia.edu/Documents/in/Translations">Translations</a><script data-card-contents-for-ri="44355" type="text/json">{"id":44355,"name":"Translations","url":"https://www.academia.edu/Documents/in/Translations?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=11370606]'), work: {"id":11370606,"title":"Validation of the Italian version of the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E)","created_at":"2015-03-11T05:55:04.207-07:00","url":"https://www.academia.edu/11370606/Validation_of_the_Italian_version_of_the_Neurological_Disorders_Depression_Inventory_for_Epilepsy_NDDI_E_?f_ri=7648","dom_id":"work_11370606","summary":"The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) was developed for the rapid detection of a major depressive episode in people with epilepsy. It has been proven to be a user-friendly screening instrument. This study describes the development, validation, and psychometric properties of the Italian version of the NDDI-E. A consecutive sample of 120 outpatients with epilepsy has been assessed using the M.I.N.I. Plus version 5.0.0 and the NDDI-E. All patients had no major difficulties in understanding or answering the questions of the Italian version. Cronbach's alpha coefficient was 0.851. Receiver operating characteristic analysis showed an area under the curve of 0.943 (CI95% = 0.902-0.985; SE 0.021; p b 0.001), a cut off score of 13, a sensitivity of 86.2%, a specificity of 89%, a positive predictive value of 71.4%, and a negative predictive value of 95.3%.","downloadable_attachments":[{"id":46746270,"asset_id":11370606,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":27638894,"first_name":"Marco","last_name":"Mula","domain_name":"sgul","page_name":"MarcoMula","display_name":"Marco Mula","profile_url":"https://sgul.academia.edu/MarcoMula?f_ri=7648","photo":"https://0.academia-photos.com/27638894/8051312/35119280/s65_marco.mula.jpg"}],"research_interests":[{"id":2599,"name":"Psychometrics","url":"https://www.academia.edu/Documents/in/Psychometrics?f_ri=7648","nofollow":true},{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":44355,"name":"Translations","url":"https://www.academia.edu/Documents/in/Translations?f_ri=7648","nofollow":true},{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy?f_ri=7648"},{"id":77794,"name":"Major Depressive Disorder","url":"https://www.academia.edu/Documents/in/Major_Depressive_Disorder?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results?f_ri=7648"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity?f_ri=7648"},{"id":2467529,"name":"Psychiatric Status Rating Scales","url":"https://www.academia.edu/Documents/in/Psychiatric_Status_Rating_Scales?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_12662047" data-work_id="12662047" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/12662047/Adjunctive_therapy_versus_alternative_monotherapy_in_patients_with_partial_epilepsy_failing_on_a_single_drug_a_multicentre_randomised_pragmatic_controlled_trial">Adjunctive therapy versus alternative monotherapy in patients with partial epilepsy failing on a single drug: a multicentre, randomised, pragmatic controlled trial</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objective: To evaluate the value of alternative monotherapy versus adjunctive therapy in partial epilepsy refractory to single antiepileptic drug (AED) therapy. Design and methods: In a multicentre, parallel-group, open-label study,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_12662047" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objective: To evaluate the value of alternative monotherapy versus adjunctive therapy in partial epilepsy refractory to single antiepileptic drug (AED) therapy. Design and methods: In a multicentre, parallel-group, open-label study, patients with cryptogenic or symptomatic partial epilepsy not controlled after single or sequential AED monotherapies were randomised to monotherapy with an alternative AED or to adjunctive therapy with a second AED. The AED to be added/substituted and dose adjustments were determined by the physician's best judgement. Patients were followed up until withdrawal from the allocated treatment or for 12 months, whichever first. Outcome measures included proportion of patients continuing on the assigned treatment strategy, proportion of patients seizure-free after achieving the target maintenance dose, and adverse effects rates. Data were analysed by actuarial life tables, Kaplan-Meier survival analysis and Cox proportional hazard regression model. Results: Of a total of 157 patients (including 94 previously exposed to only one AED), 76 were randomised to alternative monotherapy and 81 to adjunctive therapy. The two groups were balanced in clinical characteristics. The 12-month cumulative probability of remaining on the assigned treatment was 55% in patients randomised to alternative monotherapy and 65% in those randomised to adjunctive therapy (P = 0.74). The 12-month probability of remaining seizure-free was 14 and 16%, respectively (P = 0.74).</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/12662047" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="907b3ac09805d50f4f9c21e804d6e617" rel="nofollow" data-download="{"attachment_id":46020198,"asset_id":12662047,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46020198/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="31659738" href="https://independent.academia.edu/EttoreBeghi">Ettore Beghi</a><script data-card-contents-for-user="31659738" type="text/json">{"id":31659738,"first_name":"Ettore","last_name":"Beghi","domain_name":"independent","page_name":"EttoreBeghi","display_name":"Ettore Beghi","profile_url":"https://independent.academia.edu/EttoreBeghi?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_12662047 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="12662047"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 12662047, container: ".js-paper-rank-work_12662047", }); 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$(".js-view-count[data-work-id=12662047]").text(description); $(".js-view-count-work_12662047").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_12662047").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="12662047"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10610" rel="nofollow" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a>, <script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" rel="nofollow" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a><script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=12662047]'), work: {"id":12662047,"title":"Adjunctive therapy versus alternative monotherapy in patients with partial epilepsy failing on a single drug: a multicentre, randomised, pragmatic controlled trial","created_at":"2015-05-28T23:54:07.390-07:00","url":"https://www.academia.edu/12662047/Adjunctive_therapy_versus_alternative_monotherapy_in_patients_with_partial_epilepsy_failing_on_a_single_drug_a_multicentre_randomised_pragmatic_controlled_trial?f_ri=7648","dom_id":"work_12662047","summary":"Objective: To evaluate the value of alternative monotherapy versus adjunctive therapy in partial epilepsy refractory to single antiepileptic drug (AED) therapy. Design and methods: In a multicentre, parallel-group, open-label study, patients with cryptogenic or symptomatic partial epilepsy not controlled after single or sequential AED monotherapies were randomised to monotherapy with an alternative AED or to adjunctive therapy with a second AED. The AED to be added/substituted and dose adjustments were determined by the physician's best judgement. Patients were followed up until withdrawal from the allocated treatment or for 12 months, whichever first. Outcome measures included proportion of patients continuing on the assigned treatment strategy, proportion of patients seizure-free after achieving the target maintenance dose, and adverse effects rates. Data were analysed by actuarial life tables, Kaplan-Meier survival analysis and Cox proportional hazard regression model. Results: Of a total of 157 patients (including 94 previously exposed to only one AED), 76 were randomised to alternative monotherapy and 81 to adjunctive therapy. The two groups were balanced in clinical characteristics. The 12-month cumulative probability of remaining on the assigned treatment was 55% in patients randomised to alternative monotherapy and 65% in those randomised to adjunctive therapy (P = 0.74). The 12-month probability of remaining seizure-free was 14 and 16%, respectively (P = 0.74).","downloadable_attachments":[{"id":46020198,"asset_id":12662047,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":31659738,"first_name":"Ettore","last_name":"Beghi","domain_name":"independent","page_name":"EttoreBeghi","display_name":"Ettore Beghi","profile_url":"https://independent.academia.edu/EttoreBeghi?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=7648","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=7648","nofollow":true},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=7648","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=7648"},{"id":129744,"name":"Confidence intervals","url":"https://www.academia.edu/Documents/in/Confidence_intervals?f_ri=7648"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=7648"},{"id":171933,"name":"Statistical Power","url":"https://www.academia.edu/Documents/in/Statistical_Power?f_ri=7648"},{"id":194055,"name":"Randomised Controlled Trial","url":"https://www.academia.edu/Documents/in/Randomised_Controlled_Trial?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=7648"},{"id":372494,"name":"Kaplan-Meier","url":"https://www.academia.edu/Documents/in/Kaplan-Meier?f_ri=7648"},{"id":406051,"name":"Regression Model","url":"https://www.academia.edu/Documents/in/Regression_Model?f_ri=7648"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy?f_ri=7648"},{"id":873543,"name":"Life Table","url":"https://www.academia.edu/Documents/in/Life_Table?f_ri=7648"},{"id":1147505,"name":"Antiepileptic Drug","url":"https://www.academia.edu/Documents/in/Antiepileptic_Drug?f_ri=7648"},{"id":1272981,"name":"Proportional Hazards Models","url":"https://www.academia.edu/Documents/in/Proportional_Hazards_Models?f_ri=7648"},{"id":1993786,"name":"Cumulant","url":"https://www.academia.edu/Documents/in/Cumulant?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_25225535" data-work_id="25225535" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/25225535/Biomimicry_Applying_design_for_nature_to_solve_problems_in_epilepsy_research">Biomimicry: Applying design for nature to solve problems in epilepsy research</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/25225535" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" 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Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=25225535]'), work: {"id":25225535,"title":"Biomimicry: Applying design for nature to solve problems in epilepsy research","created_at":"2016-05-11T03:16:42.213-07:00","url":"https://www.academia.edu/25225535/Biomimicry_Applying_design_for_nature_to_solve_problems_in_epilepsy_research?f_ri=7648","dom_id":"work_25225535","summary":null,"downloadable_attachments":[{"id":45725927,"asset_id":25225535,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":48459641,"first_name":"Esper","last_name":"Cavalheiro","domain_name":"unifesp","page_name":"ECavalheiro","display_name":"Esper Cavalheiro","profile_url":"https://unifesp.academia.edu/ECavalheiro?f_ri=7648","photo":"https://0.academia-photos.com/48459641/21618967/20960492/s65_esper.cavalheiro.jpg"}],"research_interests":[{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design?f_ri=7648","nofollow":true},{"id":5467,"name":"Biomimetics","url":"https://www.academia.edu/Documents/in/Biomimetics?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13336728 coauthored" data-work_id="13336728" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13336728/Prognostic_factors_for_acute_encephalopathy_with_bright_tree_appearance">Prognostic factors for acute encephalopathy with bright tree appearance</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">To determine the prognostic factors for encephalopathy with bright tree appearance (BTA) in the acute phase through retrospective case evaluation. We recruited 10 children with encephalopathy who presented with BTA and classified them... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13336728" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">To determine the prognostic factors for encephalopathy with bright tree appearance (BTA) in the acute phase through retrospective case evaluation. We recruited 10 children with encephalopathy who presented with BTA and classified them into 2 groups. Six patients with evident regression and severe psychomotor developmental delay after encephalopathy were included in the severe group, while the remaining 4 patients with mild mental retardation were included in the mild group. We retrospectively analyzed their clinical symptoms, laboratory data, and magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) findings. Patients in the severe group developed subsequent complications such as epilepsy and severe motor impairment. Univariate analysis revealed that higher maximum lactate dehydrogenase (LDH) levels (p=0.055) were a weak predictor of poor outcome. Maximum creatinine levels were significantly higher (p&lt;0.05) and minimal platelet counts were significantly lower...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13336728" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fae3ac1f46569b2674ea7e5fc3132b77" rel="nofollow" data-download="{"attachment_id":45452442,"asset_id":13336728,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45452442/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32577277" href="https://independent.academia.edu/YukihiroKitai">Yukihiro Kitai</a><script data-card-contents-for-user="32577277" type="text/json">{"id":32577277,"first_name":"Yukihiro","last_name":"Kitai","domain_name":"independent","page_name":"YukihiroKitai","display_name":"Yukihiro Kitai","profile_url":"https://independent.academia.edu/YukihiroKitai?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-13336728">+1</span><div class="hidden js-additional-users-13336728"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/TakehisaYamamoto">Takehisa Yamamoto</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-13336728'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-13336728').html(); 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We recruited 10 children with encephalopathy who presented with BTA and classified them into 2 groups. Six patients with evident regression and severe psychomotor developmental delay after encephalopathy were included in the severe group, while the remaining 4 patients with mild mental retardation were included in the mild group. We retrospectively analyzed their clinical symptoms, laboratory data, and magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) findings. Patients in the severe group developed subsequent complications such as epilepsy and severe motor impairment. Univariate analysis revealed that higher maximum lactate dehydrogenase (LDH) levels (p=0.055) were a weak predictor of poor outcome. Maximum creatinine levels were significantly higher (p\u0026lt;0.05) and minimal platelet counts were significantly lower...","downloadable_attachments":[{"id":45452442,"asset_id":13336728,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32577277,"first_name":"Yukihiro","last_name":"Kitai","domain_name":"independent","page_name":"YukihiroKitai","display_name":"Yukihiro Kitai","profile_url":"https://independent.academia.edu/YukihiroKitai?f_ri=7648","photo":"/images/s65_no_pic.png"},{"id":32617989,"first_name":"Takehisa","last_name":"Yamamoto","domain_name":"independent","page_name":"TakehisaYamamoto","display_name":"Takehisa Yamamoto","profile_url":"https://independent.academia.edu/TakehisaYamamoto?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy?f_ri=7648","nofollow":true},{"id":29538,"name":"Brain development","url":"https://www.academia.edu/Documents/in/Brain_development?f_ri=7648","nofollow":true},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=7648"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=7648"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=7648"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=7648"},{"id":853012,"name":"Diazepam","url":"https://www.academia.edu/Documents/in/Diazepam?f_ri=7648"},{"id":1438730,"name":"Creatinine","url":"https://www.academia.edu/Documents/in/Creatinine?f_ri=7648"},{"id":1619781,"name":"Midazolam","url":"https://www.academia.edu/Documents/in/Midazolam?f_ri=7648"},{"id":1765793,"name":"Brain Diseases","url":"https://www.academia.edu/Documents/in/Brain_Diseases?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_25107699" data-work_id="25107699" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/25107699/Seizure_prediction_and_the_preseizure_period">Seizure prediction and the preseizure period</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/25107699" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="bf01e7a7bed05c1b18ffd5f9346fde48" rel="nofollow" data-download="{"attachment_id":45426950,"asset_id":25107699,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45426950/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32745639" href="https://independent.academia.edu/BLitt">Brian Litt</a><script data-card-contents-for-user="32745639" type="text/json">{"id":32745639,"first_name":"Brian","last_name":"Litt","domain_name":"independent","page_name":"BLitt","display_name":"Brian Litt","profile_url":"https://independent.academia.edu/BLitt?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_25107699 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="25107699"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 25107699, container: ".js-paper-rank-work_25107699", }); 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$(".js-view-count[data-work-id=25107699]").text(description); $(".js-view-count-work_25107699").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_25107699").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="25107699"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="237" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10904" rel="nofollow" href="https://www.academia.edu/Documents/in/Electroencephalography">Electroencephalography</a>, <script data-card-contents-for-ri="10904" type="text/json">{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="61474" rel="nofollow" href="https://www.academia.edu/Documents/in/Brain">Brain</a><script data-card-contents-for-ri="61474" type="text/json">{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=25107699]'), work: {"id":25107699,"title":"Seizure prediction and the preseizure period","created_at":"2016-05-07T06:45:33.264-07:00","url":"https://www.academia.edu/25107699/Seizure_prediction_and_the_preseizure_period?f_ri=7648","dom_id":"work_25107699","summary":null,"downloadable_attachments":[{"id":45426950,"asset_id":25107699,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32745639,"first_name":"Brian","last_name":"Litt","domain_name":"independent","page_name":"BLitt","display_name":"Brian Litt","profile_url":"https://independent.academia.edu/BLitt?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648","nofollow":true},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=7648","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=7648"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=7648"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13390205 coauthored" data-work_id="13390205" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13390205/Use_of_the_DISCERN_tool_for_evaluating_web_searches_in_childhood_epilepsy">Use of the DISCERN tool for evaluating web searches in childhood epilepsy</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Epilepsy is an important cause of neurological disability in children. Nowadays, an increasing number of parents or caregivers use the Internet as a source of health information concerning symptoms, therapy, and prognosis of epilepsy... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13390205" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Epilepsy is an important cause of neurological disability in children. Nowadays, an increasing number of parents or caregivers use the Internet as a source of health information concerning symptoms, therapy, and prognosis of epilepsy occurring during childhood. Therefore, high-quality websites are necessary to satisfy this request. Using the DISCERN tool, we evaluated online information on childhood epilepsy provided by the first 50 links displayed on the Google search engine. The same links were evaluated by a team of pediatric neurologists (PNs) and by a lay subject (LS). The evaluation performed by the PNs found out that only 9.6% of the websites showed good reliability, that only 7.2% of the websites had a good quality of information on treatment choices, and that only 21.5% of the websites showed good overall quality of the content. With regard to the evaluation performed by the neutral subject, it was found that 21.4% of the websites showed good reliability, that 59.5% of the websites showed poor quality of information on treatment choices, and that only 2% of the websites showed good overall quality of the content. Our conclusion is that online information about childhood epilepsy still lacks reliability, accuracy, and relevance as well as fails to provide a thorough review of treatment choices.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13390205" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3e1876f7e4cafb3ae80b5f4879b04012" rel="nofollow" data-download="{"attachment_id":45394493,"asset_id":13390205,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45394493/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32733249" href="https://uniroma2.academia.edu/NadiaMalhany">Nadia El Malhany</a><script data-card-contents-for-user="32733249" type="text/json">{"id":32733249,"first_name":"Nadia","last_name":"El Malhany","domain_name":"uniroma2","page_name":"NadiaMalhany","display_name":"Nadia El Malhany","profile_url":"https://uniroma2.academia.edu/NadiaMalhany?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-13390205">+1</span><div class="hidden js-additional-users-13390205"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://uniroma2.academia.edu/PaoloCuratolo">Paolo Curatolo</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-13390205'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-13390205').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_13390205 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13390205"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13390205, container: ".js-paper-rank-work_13390205", }); });</script></li><li class="js-percentile-work_13390205 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13390205; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_13390205"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_13390205 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="13390205"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13390205; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13390205]").text(description); $(".js-view-count-work_13390205").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13390205").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13390205"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="623" rel="nofollow" href="https://www.academia.edu/Documents/in/Neurology">Neurology</a>, <script data-card-contents-for-ri="623" type="text/json">{"id":623,"name":"Neurology","url":"https://www.academia.edu/Documents/in/Neurology?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="631" rel="nofollow" href="https://www.academia.edu/Documents/in/Pediatrics">Pediatrics</a>, <script data-card-contents-for-ri="631" type="text/json">{"id":631,"name":"Pediatrics","url":"https://www.academia.edu/Documents/in/Pediatrics?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="53293" rel="nofollow" href="https://www.academia.edu/Documents/in/Software">Software</a><script data-card-contents-for-ri="53293" type="text/json">{"id":53293,"name":"Software","url":"https://www.academia.edu/Documents/in/Software?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13390205]'), work: {"id":13390205,"title":"Use of the DISCERN tool for evaluating web searches in childhood epilepsy","created_at":"2015-06-28T13:19:06.913-07:00","url":"https://www.academia.edu/13390205/Use_of_the_DISCERN_tool_for_evaluating_web_searches_in_childhood_epilepsy?f_ri=7648","dom_id":"work_13390205","summary":"Epilepsy is an important cause of neurological disability in children. Nowadays, an increasing number of parents or caregivers use the Internet as a source of health information concerning symptoms, therapy, and prognosis of epilepsy occurring during childhood. Therefore, high-quality websites are necessary to satisfy this request. Using the DISCERN tool, we evaluated online information on childhood epilepsy provided by the first 50 links displayed on the Google search engine. The same links were evaluated by a team of pediatric neurologists (PNs) and by a lay subject (LS). The evaluation performed by the PNs found out that only 9.6% of the websites showed good reliability, that only 7.2% of the websites had a good quality of information on treatment choices, and that only 21.5% of the websites showed good overall quality of the content. With regard to the evaluation performed by the neutral subject, it was found that 21.4% of the websites showed good reliability, that 59.5% of the websites showed poor quality of information on treatment choices, and that only 2% of the websites showed good overall quality of the content. Our conclusion is that online information about childhood epilepsy still lacks reliability, accuracy, and relevance as well as fails to provide a thorough review of treatment choices.","downloadable_attachments":[{"id":45394493,"asset_id":13390205,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32733249,"first_name":"Nadia","last_name":"El Malhany","domain_name":"uniroma2","page_name":"NadiaMalhany","display_name":"Nadia El Malhany","profile_url":"https://uniroma2.academia.edu/NadiaMalhany?f_ri=7648","photo":"/images/s65_no_pic.png"},{"id":32615545,"first_name":"Paolo","last_name":"Curatolo","domain_name":"uniroma2","page_name":"PaoloCuratolo","display_name":"Paolo Curatolo","profile_url":"https://uniroma2.academia.edu/PaoloCuratolo?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":623,"name":"Neurology","url":"https://www.academia.edu/Documents/in/Neurology?f_ri=7648","nofollow":true},{"id":631,"name":"Pediatrics","url":"https://www.academia.edu/Documents/in/Pediatrics?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":53293,"name":"Software","url":"https://www.academia.edu/Documents/in/Software?f_ri=7648","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=7648"},{"id":137780,"name":"Search Engine","url":"https://www.academia.edu/Documents/in/Search_Engine?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":303598,"name":"Parents","url":"https://www.academia.edu/Documents/in/Parents?f_ri=7648"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=7648"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results?f_ri=7648"},{"id":1191356,"name":"Internet","url":"https://www.academia.edu/Documents/in/Internet?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14696950" data-work_id="14696950" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14696950/Seizures_in_the_elderly_Development_and_validation_of_a_diagnostic_algorithm">Seizures in the elderly: Development and validation of a diagnostic algorithm</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Seizures are frequent in the elderly, but their diagnosis can be challenging. The objective of this work was to develop and validate an expert-based algorithm for the diagnosis of seizures in elderly people. A multidisciplinary group of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14696950" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Seizures are frequent in the elderly, but their diagnosis can be challenging. The objective of this work was to develop and validate an expert-based algorithm for the diagnosis of seizures in elderly people. A multidisciplinary group of neurologists and geriatricians developed a diagnostic algorithm using a combination of selected clinical, electroencephalographical and radiological criteria. The algorithm was validated by multicentre retrospective analysis of data of patients referred for specific symptoms and classified by the experts as epileptic patients or not. The algorithm was applied to all the patients, and the diagnosis provided by the algorithm was compared to the clinical diagnosis of the experts. Twenty-nine clinical, electroencephalographical and radiological criteria were selected for the algorithm. According to criteria combination, seizures were classified in four levels of diagnosis: certain, highly probable, possible or improbable. To validate the algorithm, the medical records of 269 elderly patients were analyzed (138 with epileptic seizures, 131 with non-epileptic manifestations). Patients were mainly referred for a transient focal deficit (40%), confusion (38%), S. Dupont et al.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14696950" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="358a47dd894ccec811754c31e402fe82" rel="nofollow" data-download="{"attachment_id":43968679,"asset_id":14696950,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43968679/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33647239" href="https://independent.academia.edu/St%C3%A9phaneSch%C3%BCck">Stéphane Schück</a><script data-card-contents-for-user="33647239" type="text/json">{"id":33647239,"first_name":"Stéphane","last_name":"Schück","domain_name":"independent","page_name":"StéphaneSchück","display_name":"Stéphane Schück","profile_url":"https://independent.academia.edu/St%C3%A9phaneSch%C3%BCck?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14696950 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14696950"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14696950, container: ".js-paper-rank-work_14696950", }); 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The objective of this work was to develop and validate an expert-based algorithm for the diagnosis of seizures in elderly people. A multidisciplinary group of neurologists and geriatricians developed a diagnostic algorithm using a combination of selected clinical, electroencephalographical and radiological criteria. The algorithm was validated by multicentre retrospective analysis of data of patients referred for specific symptoms and classified by the experts as epileptic patients or not. The algorithm was applied to all the patients, and the diagnosis provided by the algorithm was compared to the clinical diagnosis of the experts. Twenty-nine clinical, electroencephalographical and radiological criteria were selected for the algorithm. According to criteria combination, seizures were classified in four levels of diagnosis: certain, highly probable, possible or improbable. To validate the algorithm, the medical records of 269 elderly patients were analyzed (138 with epileptic seizures, 131 with non-epileptic manifestations). Patients were mainly referred for a transient focal deficit (40%), confusion (38%), S. Dupont et al.","downloadable_attachments":[{"id":43968679,"asset_id":14696950,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33647239,"first_name":"Stéphane","last_name":"Schück","domain_name":"independent","page_name":"StéphaneSchück","display_name":"Stéphane Schück","profile_url":"https://independent.academia.edu/St%C3%A9phaneSch%C3%BCck?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":428,"name":"Algorithms","url":"https://www.academia.edu/Documents/in/Algorithms?f_ri=7648","nofollow":true},{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=7648","nofollow":true},{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=7648"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=7648"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity?f_ri=7648"},{"id":959921,"name":"X ray Computed Tomography","url":"https://www.academia.edu/Documents/in/X_ray_Computed_Tomography?f_ri=7648"},{"id":1294607,"name":"Logistic Models","url":"https://www.academia.edu/Documents/in/Logistic_Models?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14732731" data-work_id="14732731" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14732731/Autism_and_epilepsy_Cause_consequence_comorbidity_or_coincidence">Autism and epilepsy: Cause, consequence, comorbidity, or coincidence?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Autism is associated with epilepsy in early childhood, with evidence suggesting that individuals with both autism and more severe cognitive impairment are at higher risk. However, the incidence of an abnormal electroencephalogram and/or... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14732731" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Autism is associated with epilepsy in early childhood, with evidence suggesting that individuals with both autism and more severe cognitive impairment are at higher risk. However, the incidence of an abnormal electroencephalogram and/or epilepsy in the full range of pervasive developmental disorders (PDDs) is not well defined. This naturalistic study addresses the incidence of epilepsy and electroencephalographic abnormalities in children</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14732731" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e5ced5d22a38822b4abc34365d20e32c" rel="nofollow" data-download="{"attachment_id":43934241,"asset_id":14732731,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43934241/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33694608" href="https://telaviv.academia.edu/LidiaGabis">Lidia Gabis</a><script data-card-contents-for-user="33694608" type="text/json">{"id":33694608,"first_name":"Lidia","last_name":"Gabis","domain_name":"telaviv","page_name":"LidiaGabis","display_name":"Lidia Gabis","profile_url":"https://telaviv.academia.edu/LidiaGabis?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14732731 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14732731"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14732731, container: ".js-paper-rank-work_14732731", }); 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$(".js-view-count[data-work-id=14732731]").text(description); $(".js-view-count-work_14732731").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14732731").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14732731"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2249" rel="nofollow" href="https://www.academia.edu/Documents/in/Autism">Autism</a>, <script data-card-contents-for-ri="2249" type="text/json">{"id":2249,"name":"Autism","url":"https://www.academia.edu/Documents/in/Autism?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10904" rel="nofollow" href="https://www.academia.edu/Documents/in/Electroencephalography">Electroencephalography</a>, <script data-card-contents-for-ri="10904" type="text/json">{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a><script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14732731]'), work: {"id":14732731,"title":"Autism and epilepsy: Cause, consequence, comorbidity, or coincidence?","created_at":"2015-08-07T01:07:21.749-07:00","url":"https://www.academia.edu/14732731/Autism_and_epilepsy_Cause_consequence_comorbidity_or_coincidence?f_ri=7648","dom_id":"work_14732731","summary":"Autism is associated with epilepsy in early childhood, with evidence suggesting that individuals with both autism and more severe cognitive impairment are at higher risk. However, the incidence of an abnormal electroencephalogram and/or epilepsy in the full range of pervasive developmental disorders (PDDs) is not well defined. This naturalistic study addresses the incidence of epilepsy and electroencephalographic abnormalities in children","downloadable_attachments":[{"id":43934241,"asset_id":14732731,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33694608,"first_name":"Lidia","last_name":"Gabis","domain_name":"telaviv","page_name":"LidiaGabis","display_name":"Lidia Gabis","profile_url":"https://telaviv.academia.edu/LidiaGabis?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2249,"name":"Autism","url":"https://www.academia.edu/Documents/in/Autism?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=7648","nofollow":true},{"id":30140,"name":"Early Childhood","url":"https://www.academia.edu/Documents/in/Early_Childhood?f_ri=7648"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=7648"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=7648"},{"id":187814,"name":"Electroencephalogram","url":"https://www.academia.edu/Documents/in/Electroencephalogram?f_ri=7648"},{"id":208187,"name":"Pervasive Developmental Disorder","url":"https://www.academia.edu/Documents/in/Pervasive_Developmental_Disorder?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":321836,"name":"Spectrum","url":"https://www.academia.edu/Documents/in/Spectrum?f_ri=7648"},{"id":341121,"name":"Cognitive impairment","url":"https://www.academia.edu/Documents/in/Cognitive_impairment?f_ri=7648"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=7648"},{"id":701873,"name":"Asperger Syndrome","url":"https://www.academia.edu/Documents/in/Asperger_Syndrome?f_ri=7648"},{"id":1666741,"name":"Clinical evaluation","url":"https://www.academia.edu/Documents/in/Clinical_evaluation?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14921167" data-work_id="14921167" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14921167/What_are_the_concerns_of_older_adults_living_with_epilepsy">What are the concerns of older adults living with epilepsy?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Purpose. The goal of this work was to examine the concerns of living with recurrent seizures as expressed by older adults with epilepsy (OAE).</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14921167" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="839f19de73cbe7ffbfd5534cbcec8153" rel="nofollow" data-download="{"attachment_id":43769570,"asset_id":14921167,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43769570/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33909317" href="https://ua-birmingham.academia.edu/LauraVogtle">Laura Vogtle</a><script data-card-contents-for-user="33909317" type="text/json">{"id":33909317,"first_name":"Laura","last_name":"Vogtle","domain_name":"ua-birmingham","page_name":"LauraVogtle","display_name":"Laura Vogtle","profile_url":"https://ua-birmingham.academia.edu/LauraVogtle?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14921167 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14921167"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14921167, container: ".js-paper-rank-work_14921167", }); 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$(".js-view-count[data-work-id=14921167]").text(description); $(".js-view-count-work_14921167").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14921167").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14921167"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="7470" rel="nofollow" href="https://www.academia.edu/Documents/in/Quality_of_life">Quality of life</a>, <script data-card-contents-for-ri="7470" type="text/json">{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="44529" rel="nofollow" href="https://www.academia.edu/Documents/in/Activities_of_Daily_Living">Activities of Daily Living</a>, <script data-card-contents-for-ri="44529" type="text/json">{"id":44529,"name":"Activities of Daily Living","url":"https://www.academia.edu/Documents/in/Activities_of_Daily_Living?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="232534" rel="nofollow" href="https://www.academia.edu/Documents/in/Health_Status">Health Status</a><script data-card-contents-for-ri="232534" type="text/json">{"id":232534,"name":"Health Status","url":"https://www.academia.edu/Documents/in/Health_Status?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14921167]'), work: {"id":14921167,"title":"What are the concerns of older adults living with epilepsy?","created_at":"2015-08-14T06:53:57.651-07:00","url":"https://www.academia.edu/14921167/What_are_the_concerns_of_older_adults_living_with_epilepsy?f_ri=7648","dom_id":"work_14921167","summary":"Purpose. The goal of this work was to examine the concerns of living with recurrent seizures as expressed by older adults with epilepsy (OAE).","downloadable_attachments":[{"id":43769570,"asset_id":14921167,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33909317,"first_name":"Laura","last_name":"Vogtle","domain_name":"ua-birmingham","page_name":"LauraVogtle","display_name":"Laura Vogtle","profile_url":"https://ua-birmingham.academia.edu/LauraVogtle?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":44529,"name":"Activities of Daily Living","url":"https://www.academia.edu/Documents/in/Activities_of_Daily_Living?f_ri=7648","nofollow":true},{"id":232534,"name":"Health Status","url":"https://www.academia.edu/Documents/in/Health_Status?f_ri=7648","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=7648"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires?f_ri=7648"},{"id":584602,"name":"Geriatric Assessment","url":"https://www.academia.edu/Documents/in/Geriatric_Assessment?f_ri=7648"},{"id":806178,"name":"Older Adult","url":"https://www.academia.edu/Documents/in/Older_Adult?f_ri=7648"},{"id":2248971,"name":"Automobile driving","url":"https://www.academia.edu/Documents/in/Automobile_driving?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21259261" data-work_id="21259261" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21259261/Cognition_across_the_lifespan_Antiepileptic_drugs_epilepsy_or_both">Cognition across the lifespan: Antiepileptic drugs, epilepsy, or both?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Cognitive problems in persons with epilepsy manifest over a lifetime; however, whether abnormal cognition in an individual with epilepsy is a result of comorbid brain substrate, the epilepsy itself or its underlying etiology, the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21259261" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Cognitive problems in persons with epilepsy manifest over a lifetime; however, whether abnormal cognition in an individual with epilepsy is a result of comorbid brain substrate, the epilepsy itself or its underlying etiology, the antiepileptic agents used to control it, or a combination of these and other factors remains controversial. There is a continuing need for improved therapies to control seizures and reduce the incidence of adverse events, especially those involving the central nervous system that compromise attention, intelligence, language skills, verbal and nonverbal memory, executive function, and psychomotor speeds. Although cognitive decline typically occurs among patients with more severe epilepsy, physicians must judiciously select therapy with an eye toward not only controlling seizures but also ensuring that all patients retain as much function as possible throughout their lives.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21259261" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e44d5783a6d0b715e84fb1d8a73d73f0" rel="nofollow" data-download="{"attachment_id":41786398,"asset_id":21259261,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41786398/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="31848579" href="https://stanford.academia.edu/KimfordMeador">Kimford J Meador</a><script data-card-contents-for-user="31848579" type="text/json">{"id":31848579,"first_name":"Kimford","last_name":"Meador","domain_name":"stanford","page_name":"KimfordMeador","display_name":"Kimford J Meador","profile_url":"https://stanford.academia.edu/KimfordMeador?f_ri=7648","photo":"https://0.academia-photos.com/31848579/10310248/11505220/s65_kimford.meador.jpg"}</script></span></span></li><li class="js-paper-rank-work_21259261 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21259261"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21259261, container: ".js-paper-rank-work_21259261", }); });</script></li><li class="js-percentile-work_21259261 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21259261; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_21259261"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_21259261 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="21259261"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21259261; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21259261]").text(description); $(".js-view-count-work_21259261").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_21259261").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="21259261"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="161" rel="nofollow" href="https://www.academia.edu/Documents/in/Neuroscience">Neuroscience</a>, <script data-card-contents-for-ri="161" type="text/json">{"id":161,"name":"Neuroscience","url":"https://www.academia.edu/Documents/in/Neuroscience?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="236" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognitive_Psychology">Cognitive Psychology</a>, <script data-card-contents-for-ri="236" type="text/json">{"id":236,"name":"Cognitive Psychology","url":"https://www.academia.edu/Documents/in/Cognitive_Psychology?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2674" rel="nofollow" href="https://www.academia.edu/Documents/in/Intelligence">Intelligence</a>, <script data-card-contents-for-ri="2674" type="text/json">{"id":2674,"name":"Intelligence","url":"https://www.academia.edu/Documents/in/Intelligence?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4212" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognition">Cognition</a><script data-card-contents-for-ri="4212" type="text/json">{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21259261]'), work: {"id":21259261,"title":"Cognition across the lifespan: Antiepileptic drugs, epilepsy, or both?","created_at":"2016-01-30T11:58:11.191-08:00","url":"https://www.academia.edu/21259261/Cognition_across_the_lifespan_Antiepileptic_drugs_epilepsy_or_both?f_ri=7648","dom_id":"work_21259261","summary":"Cognitive problems in persons with epilepsy manifest over a lifetime; however, whether abnormal cognition in an individual with epilepsy is a result of comorbid brain substrate, the epilepsy itself or its underlying etiology, the antiepileptic agents used to control it, or a combination of these and other factors remains controversial. There is a continuing need for improved therapies to control seizures and reduce the incidence of adverse events, especially those involving the central nervous system that compromise attention, intelligence, language skills, verbal and nonverbal memory, executive function, and psychomotor speeds. Although cognitive decline typically occurs among patients with more severe epilepsy, physicians must judiciously select therapy with an eye toward not only controlling seizures but also ensuring that all patients retain as much function as possible throughout their lives.","downloadable_attachments":[{"id":41786398,"asset_id":21259261,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":31848579,"first_name":"Kimford","last_name":"Meador","domain_name":"stanford","page_name":"KimfordMeador","display_name":"Kimford J Meador","profile_url":"https://stanford.academia.edu/KimfordMeador?f_ri=7648","photo":"https://0.academia-photos.com/31848579/10310248/11505220/s65_kimford.meador.jpg"}],"research_interests":[{"id":161,"name":"Neuroscience","url":"https://www.academia.edu/Documents/in/Neuroscience?f_ri=7648","nofollow":true},{"id":236,"name":"Cognitive Psychology","url":"https://www.academia.edu/Documents/in/Cognitive_Psychology?f_ri=7648","nofollow":true},{"id":2674,"name":"Intelligence","url":"https://www.academia.edu/Documents/in/Intelligence?f_ri=7648","nofollow":true},{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648"},{"id":7736,"name":"Attention","url":"https://www.academia.edu/Documents/in/Attention?f_ri=7648"},{"id":18174,"name":"Language","url":"https://www.academia.edu/Documents/in/Language?f_ri=7648"},{"id":33732,"name":"Executive Function","url":"https://www.academia.edu/Documents/in/Executive_Function?f_ri=7648"},{"id":46858,"name":"Memory","url":"https://www.academia.edu/Documents/in/Memory?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":425873,"name":"Adverse Event","url":"https://www.academia.edu/Documents/in/Adverse_Event?f_ri=7648"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=7648"},{"id":1415133,"name":"Verbal Learning","url":"https://www.academia.edu/Documents/in/Verbal_Learning?f_ri=7648"},{"id":1627527,"name":"Cognition disorders","url":"https://www.academia.edu/Documents/in/Cognition_disorders?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_19969450" data-work_id="19969450" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/19969450/Modality_specific_organization_for_cutaneous_and_proprioceptive_sense_in_human_primary_sensory_cortex_studied_by_chronic_epicortical_recording">Modality-specific organization for cutaneous and proprioceptive sense in human primary sensory cortex studied by chronic epicortical recording</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Modality specificity of human primary somatosensory cortex was studied by recording somatosensory evoked potentials (SEPs) from subdural electrodes in a patient with intractable focal motor seizure. A newly developed device was used for... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_19969450" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Modality specificity of human primary somatosensory cortex was studied by recording somatosensory evoked potentials (SEPs) from subdural electrodes in a patient with intractable focal motor seizure. A newly developed device was used for selectively activating proprioception. The spatial and temporal distributions of proprioception-related SEPs elicited by brisk passive flexion movement at the proximal interphalangeal (PIP) joint of the middle finger</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/19969450" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e8affdd12a5acb791a2b1d4393fd1e14" rel="nofollow" data-download="{"attachment_id":41999273,"asset_id":19969450,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41999273/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="40844991" href="https://independent.academia.edu/TakeharuKunieda">Takeharu Kunieda</a><script data-card-contents-for-user="40844991" type="text/json">{"id":40844991,"first_name":"Takeharu","last_name":"Kunieda","domain_name":"independent","page_name":"TakeharuKunieda","display_name":"Takeharu Kunieda","profile_url":"https://independent.academia.edu/TakeharuKunieda?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_19969450 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="19969450"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 19969450, container: ".js-paper-rank-work_19969450", }); 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$(".js-view-count[data-work-id=19969450]").text(description); $(".js-view-count-work_19969450").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_19969450").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="19969450"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10904" rel="nofollow" href="https://www.academia.edu/Documents/in/Electroencephalography">Electroencephalography</a>, <script data-card-contents-for-ri="10904" type="text/json">{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="54214" rel="nofollow" href="https://www.academia.edu/Documents/in/Proprioception">Proprioception</a>, <script data-card-contents-for-ri="54214" type="text/json">{"id":54214,"name":"Proprioception","url":"https://www.academia.edu/Documents/in/Proprioception?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="277716" rel="nofollow" href="https://www.academia.edu/Documents/in/Somatosensory_Evoked_Potentials">Somatosensory Evoked Potentials</a><script data-card-contents-for-ri="277716" type="text/json">{"id":277716,"name":"Somatosensory Evoked Potentials","url":"https://www.academia.edu/Documents/in/Somatosensory_Evoked_Potentials?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=19969450]'), work: {"id":19969450,"title":"Modality-specific organization for cutaneous and proprioceptive sense in human primary sensory cortex studied by chronic epicortical recording","created_at":"2016-01-02T14:52:06.185-08:00","url":"https://www.academia.edu/19969450/Modality_specific_organization_for_cutaneous_and_proprioceptive_sense_in_human_primary_sensory_cortex_studied_by_chronic_epicortical_recording?f_ri=7648","dom_id":"work_19969450","summary":"Modality specificity of human primary somatosensory cortex was studied by recording somatosensory evoked potentials (SEPs) from subdural electrodes in a patient with intractable focal motor seizure. A newly developed device was used for selectively activating proprioception. The spatial and temporal distributions of proprioception-related SEPs elicited by brisk passive flexion movement at the proximal interphalangeal (PIP) joint of the middle finger","downloadable_attachments":[{"id":41999273,"asset_id":19969450,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":40844991,"first_name":"Takeharu","last_name":"Kunieda","domain_name":"independent","page_name":"TakeharuKunieda","display_name":"Takeharu Kunieda","profile_url":"https://independent.academia.edu/TakeharuKunieda?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648","nofollow":true},{"id":54214,"name":"Proprioception","url":"https://www.academia.edu/Documents/in/Proprioception?f_ri=7648","nofollow":true},{"id":277716,"name":"Somatosensory Evoked Potentials","url":"https://www.academia.edu/Documents/in/Somatosensory_Evoked_Potentials?f_ri=7648","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18136399" data-work_id="18136399" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18136399/Effects_of_different_types_of_physical_exercise_on_the_staining_of_parvalbumin_positive_neurons_in_the_hippocampal_formation_of_rats_with_epilepsy">Effects of different types of physical exercise on the staining of parvalbumin-positive neurons in the hippocampal formation of rats with epilepsy</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Effects of exercise in animals with epilepsy have been demonstrated. To investigate whether the type of physical activity, voluntary or forced, would promote different morphological changes in hippocampal formation we performed an... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18136399" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Effects of exercise in animals with epilepsy have been demonstrated. To investigate whether the type of physical activity, voluntary or forced, would promote different morphological changes in hippocampal formation we performed an immunocytochemical study using the parvalbumin (PV) distribution as a marker. Control rats and rats with epilepsy were submitted to a voluntary (wheel running) and forced (treadmill) exercise for 10 days (acute physical exercise) or 45 days (chronic physical exercise). It was observed in normal rats a higher number of PV-positive cells in the hilus of dentate gyrus (DG) in the voluntary and forced exercise groups (acute and chronic physical exercise), when compared to the control group. In animals with epilepsy the number of PV-positive cells and staining intensity of PV-fibers in the hilus was significantly higher only in the acute physical exercise (voluntary and forced). These findings demonstrate that acute physical exercise, both voluntary and forced results in increased number of PV-positive cells and staining intensity of PV-fibers in the hilus of rats with epilepsy and the occurrence of these changes takes place only in the early phase of epilepsy. , acute voluntary rats; T-10, acute treadmill rats; V-45, chronic voluntary rats; T-45, chronic treadmill rats; V-10 with epilepsy, acute voluntary rats with epilepsy; T-10 with epilepsy, acute treadmill rats with epilepsy; V-45 with epilepsy, chronic voluntary rats with epilepsy; T-45 with epilepsy, chronic treadmill rats with epilepsy; V-35/45 with epilepsy, rats submitted to 10 days of voluntary exercise between the 35th and 45th days, after the second SRS; T-35/45 with epilepsy, rats submitted to 10 days of treadmill exercise between the 35th and 45th days, after the second SRS.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18136399" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="eff3678952dfcf21e58caa5f67490e20" rel="nofollow" data-download="{"attachment_id":39894435,"asset_id":18136399,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/39894435/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35216120" href="https://unifesp.academia.edu/EsperCavalheiro">Esper Cavalheiro</a><script data-card-contents-for-user="35216120" type="text/json">{"id":35216120,"first_name":"Esper","last_name":"Cavalheiro","domain_name":"unifesp","page_name":"EsperCavalheiro","display_name":"Esper Cavalheiro","profile_url":"https://unifesp.academia.edu/EsperCavalheiro?f_ri=7648","photo":"https://0.academia-photos.com/35216120/18613473/18577626/s65_esper.cavalheiro.jpeg"}</script></span></span></li><li class="js-paper-rank-work_18136399 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18136399"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18136399, container: ".js-paper-rank-work_18136399", }); 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$(".js-view-count[data-work-id=18136399]").text(description); $(".js-view-count-work_18136399").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_18136399").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="18136399"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2749" rel="nofollow" href="https://www.academia.edu/Documents/in/Animal_Behavior">Animal Behavior</a>, <script data-card-contents-for-ri="2749" type="text/json">{"id":2749,"name":"Animal Behavior","url":"https://www.academia.edu/Documents/in/Animal_Behavior?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9112" rel="nofollow" href="https://www.academia.edu/Documents/in/Physical_Activity">Physical Activity</a>, <script data-card-contents-for-ri="9112" type="text/json">{"id":9112,"name":"Physical Activity","url":"https://www.academia.edu/Documents/in/Physical_Activity?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="57556" rel="nofollow" href="https://www.academia.edu/Documents/in/Hippocampus">Hippocampus</a><script data-card-contents-for-ri="57556" type="text/json">{"id":57556,"name":"Hippocampus","url":"https://www.academia.edu/Documents/in/Hippocampus?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=18136399]'), work: {"id":18136399,"title":"Effects of different types of physical exercise on the staining of parvalbumin-positive neurons in the hippocampal formation of rats with epilepsy","created_at":"2015-11-11T01:48:11.845-08:00","url":"https://www.academia.edu/18136399/Effects_of_different_types_of_physical_exercise_on_the_staining_of_parvalbumin_positive_neurons_in_the_hippocampal_formation_of_rats_with_epilepsy?f_ri=7648","dom_id":"work_18136399","summary":"Effects of exercise in animals with epilepsy have been demonstrated. To investigate whether the type of physical activity, voluntary or forced, would promote different morphological changes in hippocampal formation we performed an immunocytochemical study using the parvalbumin (PV) distribution as a marker. Control rats and rats with epilepsy were submitted to a voluntary (wheel running) and forced (treadmill) exercise for 10 days (acute physical exercise) or 45 days (chronic physical exercise). It was observed in normal rats a higher number of PV-positive cells in the hilus of dentate gyrus (DG) in the voluntary and forced exercise groups (acute and chronic physical exercise), when compared to the control group. In animals with epilepsy the number of PV-positive cells and staining intensity of PV-fibers in the hilus was significantly higher only in the acute physical exercise (voluntary and forced). These findings demonstrate that acute physical exercise, both voluntary and forced results in increased number of PV-positive cells and staining intensity of PV-fibers in the hilus of rats with epilepsy and the occurrence of these changes takes place only in the early phase of epilepsy. , acute voluntary rats; T-10, acute treadmill rats; V-45, chronic voluntary rats; T-45, chronic treadmill rats; V-10 with epilepsy, acute voluntary rats with epilepsy; T-10 with epilepsy, acute treadmill rats with epilepsy; V-45 with epilepsy, chronic voluntary rats with epilepsy; T-45 with epilepsy, chronic treadmill rats with epilepsy; V-35/45 with epilepsy, rats submitted to 10 days of voluntary exercise between the 35th and 45th days, after the second SRS; T-35/45 with epilepsy, rats submitted to 10 days of treadmill exercise between the 35th and 45th days, after the second SRS.","downloadable_attachments":[{"id":39894435,"asset_id":18136399,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35216120,"first_name":"Esper","last_name":"Cavalheiro","domain_name":"unifesp","page_name":"EsperCavalheiro","display_name":"Esper Cavalheiro","profile_url":"https://unifesp.academia.edu/EsperCavalheiro?f_ri=7648","photo":"https://0.academia-photos.com/35216120/18613473/18577626/s65_esper.cavalheiro.jpeg"}],"research_interests":[{"id":2749,"name":"Animal Behavior","url":"https://www.academia.edu/Documents/in/Animal_Behavior?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":9112,"name":"Physical Activity","url":"https://www.academia.edu/Documents/in/Physical_Activity?f_ri=7648","nofollow":true},{"id":57556,"name":"Hippocampus","url":"https://www.academia.edu/Documents/in/Hippocampus?f_ri=7648","nofollow":true},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons?f_ri=7648"},{"id":246876,"name":"Dentate Gyrus","url":"https://www.academia.edu/Documents/in/Dentate_Gyrus?f_ri=7648"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=7648"},{"id":390353,"name":"Pilocarpine","url":"https://www.academia.edu/Documents/in/Pilocarpine?f_ri=7648"},{"id":413194,"name":"Analysis of Variance","url":"https://www.academia.edu/Documents/in/Analysis_of_Variance?f_ri=7648"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=7648"},{"id":564879,"name":"Wistar Rats","url":"https://www.academia.edu/Documents/in/Wistar_Rats?f_ri=7648"},{"id":638048,"name":"Physical Exercise","url":"https://www.academia.edu/Documents/in/Physical_Exercise?f_ri=7648"},{"id":956026,"name":"Somatic Cell Count","url":"https://www.academia.edu/Documents/in/Somatic_Cell_Count?f_ri=7648"},{"id":1631043,"name":"Control Group","url":"https://www.academia.edu/Documents/in/Control_Group?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_5350337" data-work_id="5350337" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/5350337/Drug_refractoriness_of_epileptiform_activity_in_organotypic_hippocampal_slice_cultures_depends_on_the_mode_of_provocation">Drug refractoriness of epileptiform activity in organotypic hippocampal slice cultures depends on the mode of provocation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We previously reported that low Mg 2+ or 4-aminopyridine induced seizure-like events in organotypic hippocampal slice cultures (OHSCs) were resistant to standard antiepileptic drugs . We now show that high-frequency electrical stimulation... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_5350337" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We previously reported that low Mg 2+ or 4-aminopyridine induced seizure-like events in organotypic hippocampal slice cultures (OHSCs) were resistant to standard antiepileptic drugs . We now show that high-frequency electrical stimulation induced ictal-like afterdischarges in OHSCs are effectively suppressed by the standard antiepileptic drugs phenytoin and carbamazepine. Thus, a single OHSC can express both pharmacoresistant and pharmacosensitive epileptiform activities.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/5350337" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4ed5fd14a76da18d99e0995f915c1f4b" rel="nofollow" data-download="{"attachment_id":32503039,"asset_id":5350337,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/32503039/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="7399602" href="https://independent.academia.edu/AbdulWahab32">Abdul Wahab</a><script data-card-contents-for-user="7399602" type="text/json">{"id":7399602,"first_name":"Abdul","last_name":"Wahab","domain_name":"independent","page_name":"AbdulWahab32","display_name":"Abdul Wahab","profile_url":"https://independent.academia.edu/AbdulWahab32?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_5350337 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="5350337"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 5350337, container: ".js-paper-rank-work_5350337", }); 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$(".js-view-count[data-work-id=5350337]").text(description); $(".js-view-count-work_5350337").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_5350337").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="5350337"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="2007" rel="nofollow" href="https://www.academia.edu/Documents/in/Electrophysiology">Electrophysiology</a>, <script data-card-contents-for-ri="2007" type="text/json">{"id":2007,"name":"Electrophysiology","url":"https://www.academia.edu/Documents/in/Electrophysiology?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65588" rel="nofollow" href="https://www.academia.edu/Documents/in/Anticonvulsant">Anticonvulsant</a>, <script data-card-contents-for-ri="65588" type="text/json">{"id":65588,"name":"Anticonvulsant","url":"https://www.academia.edu/Documents/in/Anticonvulsant?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="83752" rel="nofollow" href="https://www.academia.edu/Documents/in/Brain_slices">Brain slices</a><script data-card-contents-for-ri="83752" type="text/json">{"id":83752,"name":"Brain slices","url":"https://www.academia.edu/Documents/in/Brain_slices?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=5350337]'), work: {"id":5350337,"title":"Drug refractoriness of epileptiform activity in organotypic hippocampal slice cultures depends on the mode of provocation","created_at":"2013-12-07T11:54:29.908-08:00","url":"https://www.academia.edu/5350337/Drug_refractoriness_of_epileptiform_activity_in_organotypic_hippocampal_slice_cultures_depends_on_the_mode_of_provocation?f_ri=7648","dom_id":"work_5350337","summary":"We previously reported that low Mg 2+ or 4-aminopyridine induced seizure-like events in organotypic hippocampal slice cultures (OHSCs) were resistant to standard antiepileptic drugs . We now show that high-frequency electrical stimulation induced ictal-like afterdischarges in OHSCs are effectively suppressed by the standard antiepileptic drugs phenytoin and carbamazepine. Thus, a single OHSC can express both pharmacoresistant and pharmacosensitive epileptiform activities.","downloadable_attachments":[{"id":32503039,"asset_id":5350337,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":7399602,"first_name":"Abdul","last_name":"Wahab","domain_name":"independent","page_name":"AbdulWahab32","display_name":"Abdul Wahab","profile_url":"https://independent.academia.edu/AbdulWahab32?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2007,"name":"Electrophysiology","url":"https://www.academia.edu/Documents/in/Electrophysiology?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":65588,"name":"Anticonvulsant","url":"https://www.academia.edu/Documents/in/Anticonvulsant?f_ri=7648","nofollow":true},{"id":83752,"name":"Brain slices","url":"https://www.academia.edu/Documents/in/Brain_slices?f_ri=7648","nofollow":true},{"id":1032303,"name":"Antiepileptic","url":"https://www.academia.edu/Documents/in/Antiepileptic?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_66686381" data-work_id="66686381" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/66686381/Stiripentol_A_novel_antiepileptic_drug">Stiripentol. A novel antiepileptic drug</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Epilepsy is one of the most widespread pathologies of human brain, affecting approximately 1% of world population. Despite the development of new methods of seizure control, chronic administration of antiepileptic drugs (AEDs) remains the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_66686381" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Epilepsy is one of the most widespread pathologies of human brain, affecting approximately 1% of world population. Despite the development of new methods of seizure control, chronic administration of antiepileptic drugs (AEDs) remains the treatment of choice. Nevertheless, pharmacotherapy is not always effective. In the case of single drug treatment, the number of non-responding patients is as high as 30%. Moreover, chronic medication with currently available AEDs may result in severe side-effects and undesired drug interactions. That is why in recent years intensive research has been carried out aiming at the development of new therapeutic strategies in epilepsy. The goal of this review is to assemble current literature data on stiripentol (STP), a novel anticonvulsant unrelated to any other AEDs. STP potentiates central gamma-aminobutyric acid (GABA) transmission and is characterized by nonlinear pharmacokinetics and inhibition of liver microsomal enzymes. STP has proved its antic...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/66686381" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7f54bcbadbcac1ec750f864ba9b88442" rel="nofollow" data-download="{"attachment_id":77781786,"asset_id":66686381,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/77781786/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="45722389" href="https://independent.academia.edu/Stanis%C5%82awCzuczwar">Stanisław Czuczwar</a><script data-card-contents-for-user="45722389" type="text/json">{"id":45722389,"first_name":"Stanisław","last_name":"Czuczwar","domain_name":"independent","page_name":"StanisławCzuczwar","display_name":"Stanisław Czuczwar","profile_url":"https://independent.academia.edu/Stanis%C5%82awCzuczwar?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_66686381 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="66686381"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 66686381, container: ".js-paper-rank-work_66686381", }); 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$(".js-view-count[data-work-id=66686381]").text(description); $(".js-view-count-work_66686381").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_66686381").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="66686381"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="61474" rel="nofollow" href="https://www.academia.edu/Documents/in/Brain">Brain</a>, <script data-card-contents-for-ri="61474" type="text/json">{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="1619808" rel="nofollow" href="https://www.academia.edu/Documents/in/Gamma-Aminobutyric_Acid">Gamma-Aminobutyric Acid</a><script data-card-contents-for-ri="1619808" type="text/json">{"id":1619808,"name":"Gamma-Aminobutyric Acid","url":"https://www.academia.edu/Documents/in/Gamma-Aminobutyric_Acid?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=66686381]'), work: {"id":66686381,"title":"Stiripentol. A novel antiepileptic drug","created_at":"2021-12-31T01:34:26.067-08:00","url":"https://www.academia.edu/66686381/Stiripentol_A_novel_antiepileptic_drug?f_ri=7648","dom_id":"work_66686381","summary":"Epilepsy is one of the most widespread pathologies of human brain, affecting approximately 1% of world population. Despite the development of new methods of seizure control, chronic administration of antiepileptic drugs (AEDs) remains the treatment of choice. Nevertheless, pharmacotherapy is not always effective. In the case of single drug treatment, the number of non-responding patients is as high as 30%. Moreover, chronic medication with currently available AEDs may result in severe side-effects and undesired drug interactions. That is why in recent years intensive research has been carried out aiming at the development of new therapeutic strategies in epilepsy. The goal of this review is to assemble current literature data on stiripentol (STP), a novel anticonvulsant unrelated to any other AEDs. STP potentiates central gamma-aminobutyric acid (GABA) transmission and is characterized by nonlinear pharmacokinetics and inhibition of liver microsomal enzymes. STP has proved its antic...","downloadable_attachments":[{"id":77781786,"asset_id":66686381,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":45722389,"first_name":"Stanisław","last_name":"Czuczwar","domain_name":"independent","page_name":"StanisławCzuczwar","display_name":"Stanisław Czuczwar","profile_url":"https://independent.academia.edu/Stanis%C5%82awCzuczwar?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=7648","nofollow":true},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=7648","nofollow":true},{"id":1619808,"name":"Gamma-Aminobutyric Acid","url":"https://www.academia.edu/Documents/in/Gamma-Aminobutyric_Acid?f_ri=7648","nofollow":true},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_40647043" data-work_id="40647043" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/40647043/_I_care_for_them_On_artistic_ethics_in_research">"I care for them." On artistic ethics in research.</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Chapter in the edited publication "If you are not there, where are you? Mapping the Experience of Absence Seizures Through Art.", co-edited by Henny Dörr and myself.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/40647043" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b6474d05ecf1c21fada2d09df9de530e" rel="nofollow" data-download="{"attachment_id":60929347,"asset_id":40647043,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/60929347/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="221697" href="https://fontyshogeschoolvoordekunsten.academia.edu/FalkH%C3%BCbner">Falk Hübner</a><script data-card-contents-for-user="221697" type="text/json">{"id":221697,"first_name":"Falk","last_name":"Hübner","domain_name":"fontyshogeschoolvoordekunsten","page_name":"FalkHübner","display_name":"Falk Hübner","profile_url":"https://fontyshogeschoolvoordekunsten.academia.edu/FalkH%C3%BCbner?f_ri=7648","photo":"https://0.academia-photos.com/221697/2644254/3076017/s65_falk.h_bner.jpg"}</script></span></span></li><li class="js-paper-rank-work_40647043 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="40647043"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 40647043, container: ".js-paper-rank-work_40647043", }); 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$(".js-view-count[data-work-id=40647043]").text(description); $(".js-view-count-work_40647043").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_40647043").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="40647043"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="623" rel="nofollow" href="https://www.academia.edu/Documents/in/Neurology">Neurology</a>, <script data-card-contents-for-ri="623" type="text/json">{"id":623,"name":"Neurology","url":"https://www.academia.edu/Documents/in/Neurology?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="814" rel="nofollow" href="https://www.academia.edu/Documents/in/Ethics">Ethics</a>, <script data-card-contents-for-ri="814" type="text/json">{"id":814,"name":"Ethics","url":"https://www.academia.edu/Documents/in/Ethics?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2504" rel="nofollow" href="https://www.academia.edu/Documents/in/Research_Ethics">Research Ethics</a>, <script data-card-contents-for-ri="2504" type="text/json">{"id":2504,"name":"Research Ethics","url":"https://www.academia.edu/Documents/in/Research_Ethics?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4052" rel="nofollow" href="https://www.academia.edu/Documents/in/Arts_Education">Arts Education</a><script data-card-contents-for-ri="4052" type="text/json">{"id":4052,"name":"Arts Education","url":"https://www.academia.edu/Documents/in/Arts_Education?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=40647043]'), work: {"id":40647043,"title":"\"I care for them.\" On artistic ethics in research.","created_at":"2019-10-17T00:19:49.834-07:00","url":"https://www.academia.edu/40647043/_I_care_for_them_On_artistic_ethics_in_research?f_ri=7648","dom_id":"work_40647043","summary":"Chapter in the edited publication \"If you are not there, where are you? Mapping the Experience of Absence Seizures Through Art.\", co-edited by Henny Dörr and myself.","downloadable_attachments":[{"id":60929347,"asset_id":40647043,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":221697,"first_name":"Falk","last_name":"Hübner","domain_name":"fontyshogeschoolvoordekunsten","page_name":"FalkHübner","display_name":"Falk Hübner","profile_url":"https://fontyshogeschoolvoordekunsten.academia.edu/FalkH%C3%BCbner?f_ri=7648","photo":"https://0.academia-photos.com/221697/2644254/3076017/s65_falk.h_bner.jpg"}],"research_interests":[{"id":623,"name":"Neurology","url":"https://www.academia.edu/Documents/in/Neurology?f_ri=7648","nofollow":true},{"id":814,"name":"Ethics","url":"https://www.academia.edu/Documents/in/Ethics?f_ri=7648","nofollow":true},{"id":2504,"name":"Research Ethics","url":"https://www.academia.edu/Documents/in/Research_Ethics?f_ri=7648","nofollow":true},{"id":4052,"name":"Arts Education","url":"https://www.academia.edu/Documents/in/Arts_Education?f_ri=7648","nofollow":true},{"id":5799,"name":"Transdisciplinarity","url":"https://www.academia.edu/Documents/in/Transdisciplinarity?f_ri=7648"},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648"},{"id":20168,"name":"Artistic Research","url":"https://www.academia.edu/Documents/in/Artistic_Research?f_ri=7648"},{"id":22534,"name":"Practice-Based Research","url":"https://www.academia.edu/Documents/in/Practice-Based_Research?f_ri=7648"},{"id":25969,"name":"Art Education","url":"https://www.academia.edu/Documents/in/Art_Education?f_ri=7648"},{"id":26616,"name":"Arts Education and Pedagogy","url":"https://www.academia.edu/Documents/in/Arts_Education_and_Pedagogy?f_ri=7648"},{"id":49677,"name":"Arts-Based Educational Research","url":"https://www.academia.edu/Documents/in/Arts-Based_Educational_Research?f_ri=7648"},{"id":128608,"name":"Temporal Lobe Epilepsy","url":"https://www.academia.edu/Documents/in/Temporal_Lobe_Epilepsy?f_ri=7648"},{"id":275553,"name":"Arts \u0026 music in Healthcare and Education: Sector of Arts and music in the domain of Internet, ICT sector and Telecommunication society.","url":"https://www.academia.edu/Documents/in/Arts_and_music_in_Healthcare_and_Education_Sector_of_Arts_and_music_in_the_domain_of_Internet_ICT_se?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_28720902 coauthored" data-work_id="28720902" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/28720902/Levetiracetam_An_improvement_of_attention_and_of_oral_fluency_in_patients_with_partial_epilepsy">Levetiracetam: An improvement of attention and of oral fluency in patients with partial epilepsy</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Purpose: The aim of the present study is to verify whether patients with partial epilepsy receiving levetiracetam (LEV) as an add-on treatment show an improvement in cognitive function. Methods: A neuropsychological battery of tests was... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_28720902" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Purpose: The aim of the present study is to verify whether patients with partial epilepsy receiving levetiracetam (LEV) as an add-on treatment show an improvement in cognitive function. Methods: A neuropsychological battery of tests was administered to 35 patients with partial epilepsy before the assumption of LEV and after the achievement of the therapeutical dose of this drug, 7 weeks later. A control group of 35 patients with partial epilepsy was administered the same battery of tests twice, at the same time interval as the LEV group. The controls were administered the same pharmacological treatment, which did not include LEV in either of the two sessions. Results: We found a statistically significant improvement in cognitive functioning, i.e. in attention and oral fluency, in patients receiving LEV compared to the controls. The responders to LEV were 28.6%. Conclusions: LEV as an add-on therapy improved attention level and verbal fluency in our sample of patients with partial epilepsy. It is reasonable to assume that LEV may influence the metabolism of attention and of language area, as already suggested for piracetam (PIR) from which LEV derives. Further studies are needed to confirm these findings.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/28720902" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="12643e7054c06c66ea8e65fe69b39599" rel="nofollow" data-download="{"attachment_id":49127258,"asset_id":28720902,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49127258/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="54016277" href="https://independent.academia.edu/AdaPiazzini">Ada Piazzini</a><script data-card-contents-for-user="54016277" type="text/json">{"id":54016277,"first_name":"Ada","last_name":"Piazzini","domain_name":"independent","page_name":"AdaPiazzini","display_name":"Ada Piazzini","profile_url":"https://independent.academia.edu/AdaPiazzini?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-28720902">+1</span><div class="hidden js-additional-users-28720902"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://unimi.academia.edu/MariaCanevini">Maria Paola Canevini</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-28720902'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-28720902').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_28720902 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="28720902"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 28720902, container: ".js-paper-rank-work_28720902", }); });</script></li><li class="js-percentile-work_28720902 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28720902; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_28720902"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_28720902 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="28720902"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28720902; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28720902]").text(description); $(".js-view-count-work_28720902").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_28720902").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="28720902"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7736" rel="nofollow" href="https://www.academia.edu/Documents/in/Attention">Attention</a>, <script data-card-contents-for-ri="7736" type="text/json">{"id":7736,"name":"Attention","url":"https://www.academia.edu/Documents/in/Attention?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="18342" rel="nofollow" href="https://www.academia.edu/Documents/in/Speech_Disorders">Speech Disorders</a><script data-card-contents-for-ri="18342" type="text/json">{"id":18342,"name":"Speech Disorders","url":"https://www.academia.edu/Documents/in/Speech_Disorders?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=28720902]'), work: {"id":28720902,"title":"Levetiracetam: An improvement of attention and of oral fluency in patients with partial epilepsy","created_at":"2016-09-26T04:24:38.884-07:00","url":"https://www.academia.edu/28720902/Levetiracetam_An_improvement_of_attention_and_of_oral_fluency_in_patients_with_partial_epilepsy?f_ri=7648","dom_id":"work_28720902","summary":"Purpose: The aim of the present study is to verify whether patients with partial epilepsy receiving levetiracetam (LEV) as an add-on treatment show an improvement in cognitive function. Methods: A neuropsychological battery of tests was administered to 35 patients with partial epilepsy before the assumption of LEV and after the achievement of the therapeutical dose of this drug, 7 weeks later. A control group of 35 patients with partial epilepsy was administered the same battery of tests twice, at the same time interval as the LEV group. The controls were administered the same pharmacological treatment, which did not include LEV in either of the two sessions. Results: We found a statistically significant improvement in cognitive functioning, i.e. in attention and oral fluency, in patients receiving LEV compared to the controls. The responders to LEV were 28.6%. Conclusions: LEV as an add-on therapy improved attention level and verbal fluency in our sample of patients with partial epilepsy. It is reasonable to assume that LEV may influence the metabolism of attention and of language area, as already suggested for piracetam (PIR) from which LEV derives. Further studies are needed to confirm these findings.","downloadable_attachments":[{"id":49127258,"asset_id":28720902,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":54016277,"first_name":"Ada","last_name":"Piazzini","domain_name":"independent","page_name":"AdaPiazzini","display_name":"Ada Piazzini","profile_url":"https://independent.academia.edu/AdaPiazzini?f_ri=7648","photo":"/images/s65_no_pic.png"},{"id":28232761,"first_name":"Maria Paola","last_name":"Canevini","domain_name":"unimi","page_name":"MariaCanevini","display_name":"Maria Paola Canevini","profile_url":"https://unimi.academia.edu/MariaCanevini?f_ri=7648","photo":"https://0.academia-photos.com/28232761/34427861/30264415/s65_maria_paola.canevini.png"}],"research_interests":[{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":7736,"name":"Attention","url":"https://www.academia.edu/Documents/in/Attention?f_ri=7648","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=7648","nofollow":true},{"id":18342,"name":"Speech Disorders","url":"https://www.academia.edu/Documents/in/Speech_Disorders?f_ri=7648","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":441653,"name":"Cognitive Function","url":"https://www.academia.edu/Documents/in/Cognitive_Function?f_ri=7648"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy?f_ri=7648"},{"id":1237052,"name":"Piracetam","url":"https://www.academia.edu/Documents/in/Piracetam?f_ri=7648"},{"id":2467548,"name":"Neuropsychological Tests","url":"https://www.academia.edu/Documents/in/Neuropsychological_Tests?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_54115977" data-work_id="54115977" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/54115977/Cognitive_behavioral_group_treatment_program_for_adults_with_epilepsy_in_Hong_Kong">Cognitive-behavioral group treatment program for adults with epilepsy in Hong Kong</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A subjective sense of uncertainty is a common theme in the experience of patients with epilepsy. Lack of control has also been implicated as an etiologic factor in the development of psychosocial problems in epilepsy. Cognitive-behavioral... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_54115977" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A subjective sense of uncertainty is a common theme in the experience of patients with epilepsy. Lack of control has also been implicated as an etiologic factor in the development of psychosocial problems in epilepsy. Cognitive-behavioral interventions emphasizing the mediating role of thoughts and self-control appear to be particularly relevant for patients with epilepsy because anxiety and depression are the most common problems. Despite its apparent importance, very little systematic research has been published on the effectiveness of psychological treatment of epilepsy. The purpose of the present study was to conduct a seminal outcome evaluation of psychological intervention for adult patients in Hong Kong. Using a waitlist control group, the treatment program focused particularly on cognitive restructuring and seizure control. Results indicated significant gains by the treatment group in overall quality of life and self-efficacy. In particular, marked improvements were noted for emotional well-being, seizure, and stress management. The clinical implications are discussed in the context of developing specific intervention programs and outcome measures specific to the various needs of adult patients with epilepsy.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/54115977" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="bc3fb25d6cd7918cf7e4f41dc7342c91" rel="nofollow" data-download="{"attachment_id":70636420,"asset_id":54115977,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/70636420/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="43978739" href="https://independent.academia.edu/PatrickLeung8">Patrick Leung</a><script data-card-contents-for-user="43978739" type="text/json">{"id":43978739,"first_name":"Patrick","last_name":"Leung","domain_name":"independent","page_name":"PatrickLeung8","display_name":"Patrick Leung","profile_url":"https://independent.academia.edu/PatrickLeung8?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_54115977 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="54115977"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 54115977, container: ".js-paper-rank-work_54115977", }); 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$(".js-view-count[data-work-id=54115977]").text(description); $(".js-view-count-work_54115977").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_54115977").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="54115977"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="7470" rel="nofollow" href="https://www.academia.edu/Documents/in/Quality_of_life">Quality of life</a>, <script data-card-contents-for-ri="7470" type="text/json">{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9946" rel="nofollow" href="https://www.academia.edu/Documents/in/Stress_Management">Stress Management</a>, <script data-card-contents-for-ri="9946" type="text/json">{"id":9946,"name":"Stress Management","url":"https://www.academia.edu/Documents/in/Stress_Management?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="11106" rel="nofollow" href="https://www.academia.edu/Documents/in/Self_Control">Self Control</a><script data-card-contents-for-ri="11106" type="text/json">{"id":11106,"name":"Self Control","url":"https://www.academia.edu/Documents/in/Self_Control?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=54115977]'), work: {"id":54115977,"title":"Cognitive-behavioral group treatment program for adults with epilepsy in Hong Kong","created_at":"2021-09-29T21:09:18.421-07:00","url":"https://www.academia.edu/54115977/Cognitive_behavioral_group_treatment_program_for_adults_with_epilepsy_in_Hong_Kong?f_ri=7648","dom_id":"work_54115977","summary":"A subjective sense of uncertainty is a common theme in the experience of patients with epilepsy. Lack of control has also been implicated as an etiologic factor in the development of psychosocial problems in epilepsy. Cognitive-behavioral interventions emphasizing the mediating role of thoughts and self-control appear to be particularly relevant for patients with epilepsy because anxiety and depression are the most common problems. Despite its apparent importance, very little systematic research has been published on the effectiveness of psychological treatment of epilepsy. The purpose of the present study was to conduct a seminal outcome evaluation of psychological intervention for adult patients in Hong Kong. Using a waitlist control group, the treatment program focused particularly on cognitive restructuring and seizure control. Results indicated significant gains by the treatment group in overall quality of life and self-efficacy. In particular, marked improvements were noted for emotional well-being, seizure, and stress management. The clinical implications are discussed in the context of developing specific intervention programs and outcome measures specific to the various needs of adult patients with epilepsy.","downloadable_attachments":[{"id":70636420,"asset_id":54115977,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":43978739,"first_name":"Patrick","last_name":"Leung","domain_name":"independent","page_name":"PatrickLeung8","display_name":"Patrick Leung","profile_url":"https://independent.academia.edu/PatrickLeung8?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":9946,"name":"Stress Management","url":"https://www.academia.edu/Documents/in/Stress_Management?f_ri=7648","nofollow":true},{"id":11106,"name":"Self Control","url":"https://www.academia.edu/Documents/in/Self_Control?f_ri=7648","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=7648"},{"id":25021,"name":"Hong Kong","url":"https://www.academia.edu/Documents/in/Hong_Kong?f_ri=7648"},{"id":25187,"name":"Group Psychotherapy","url":"https://www.academia.edu/Documents/in/Group_Psychotherapy?f_ri=7648"},{"id":50581,"name":"Self Efficacy","url":"https://www.academia.edu/Documents/in/Self_Efficacy?f_ri=7648"},{"id":101797,"name":"Cognitive Therapy","url":"https://www.academia.edu/Documents/in/Cognitive_Therapy?f_ri=7648"},{"id":116278,"name":"Psychological Intervention","url":"https://www.academia.edu/Documents/in/Psychological_Intervention?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":1145182,"name":"Behavioral Intervention","url":"https://www.academia.edu/Documents/in/Behavioral_Intervention?f_ri=7648"},{"id":1631043,"name":"Control Group","url":"https://www.academia.edu/Documents/in/Control_Group?f_ri=7648"},{"id":2592746,"name":"Outcome measure","url":"https://www.academia.edu/Documents/in/Outcome_measure?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_28720899 coauthored" data-work_id="28720899" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/28720899/The_contribution_of_neuropsychology_to_diagnostic_assessment_in_epilepsy">The contribution of neuropsychology to diagnostic assessment in epilepsy</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Neuropsychology plays a vital role in the treatment of epilepsy, providing information on the effects of seizures on higher cortical functions through the measurement of behavioral abilities and disabilities. This is accomplished through... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_28720899" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Neuropsychology plays a vital role in the treatment of epilepsy, providing information on the effects of seizures on higher cortical functions through the measurement of behavioral abilities and disabilities. This is accomplished through the design, administration and interpretation of neuropsychological tests, including those used in functional neuroimaging or cortical mapping and in intracarotid anesthetic procedures. The objective of this paper is to define and summarize in some detail the role and methods of neuropsychologists in specialized epilepsy centers. Included are information and recommendations regarding basic ingredients of a thorough neuropsychological assessment in the epilepsy setting, as well as suggestions for an abbreviated alternative exam when needed, with emphasis on functions associated with specific brain regions. The paper is intended for novice and experienced neuropsychologists to enable them to develop or evaluate their current practices, and also for other clinicians, who seek a better understanding of the methodology underlying the neuropsychological input to their work.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/28720899" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ed25d1a3053025ab7609a762076d219e" rel="nofollow" data-download="{"attachment_id":49127255,"asset_id":28720899,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49127255/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="54016277" href="https://independent.academia.edu/AdaPiazzini">Ada Piazzini</a><script data-card-contents-for-user="54016277" type="text/json">{"id":54016277,"first_name":"Ada","last_name":"Piazzini","domain_name":"independent","page_name":"AdaPiazzini","display_name":"Ada Piazzini","profile_url":"https://independent.academia.edu/AdaPiazzini?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-28720899">+1</span><div class="hidden js-additional-users-28720899"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/TatiaLee">Tatia Lee</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-28720899'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-28720899').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_28720899 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="28720899"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 28720899, container: ".js-paper-rank-work_28720899", }); });</script></li><li class="js-percentile-work_28720899 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28720899; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_28720899"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_28720899 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="28720899"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28720899; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28720899]").text(description); $(".js-view-count-work_28720899").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_28720899").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="28720899"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="251" rel="nofollow" href="https://www.academia.edu/Documents/in/Neuropsychology">Neuropsychology</a>, <script data-card-contents-for-ri="251" type="text/json">{"id":251,"name":"Neuropsychology","url":"https://www.academia.edu/Documents/in/Neuropsychology?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="1750" rel="nofollow" href="https://www.academia.edu/Documents/in/Assessment">Assessment</a>, <script data-card-contents-for-ri="1750" type="text/json">{"id":1750,"name":"Assessment","url":"https://www.academia.edu/Documents/in/Assessment?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4212" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognition">Cognition</a>, <script data-card-contents-for-ri="4212" type="text/json">{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a><script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=28720899]'), work: {"id":28720899,"title":"The contribution of neuropsychology to diagnostic assessment in epilepsy","created_at":"2016-09-26T04:24:38.491-07:00","url":"https://www.academia.edu/28720899/The_contribution_of_neuropsychology_to_diagnostic_assessment_in_epilepsy?f_ri=7648","dom_id":"work_28720899","summary":"Neuropsychology plays a vital role in the treatment of epilepsy, providing information on the effects of seizures on higher cortical functions through the measurement of behavioral abilities and disabilities. This is accomplished through the design, administration and interpretation of neuropsychological tests, including those used in functional neuroimaging or cortical mapping and in intracarotid anesthetic procedures. The objective of this paper is to define and summarize in some detail the role and methods of neuropsychologists in specialized epilepsy centers. Included are information and recommendations regarding basic ingredients of a thorough neuropsychological assessment in the epilepsy setting, as well as suggestions for an abbreviated alternative exam when needed, with emphasis on functions associated with specific brain regions. The paper is intended for novice and experienced neuropsychologists to enable them to develop or evaluate their current practices, and also for other clinicians, who seek a better understanding of the methodology underlying the neuropsychological input to their work.","downloadable_attachments":[{"id":49127255,"asset_id":28720899,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":54016277,"first_name":"Ada","last_name":"Piazzini","domain_name":"independent","page_name":"AdaPiazzini","display_name":"Ada Piazzini","profile_url":"https://independent.academia.edu/AdaPiazzini?f_ri=7648","photo":"/images/s65_no_pic.png"},{"id":54113001,"first_name":"Tatia","last_name":"Lee","domain_name":"independent","page_name":"TatiaLee","display_name":"Tatia Lee","profile_url":"https://independent.academia.edu/TatiaLee?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":251,"name":"Neuropsychology","url":"https://www.academia.edu/Documents/in/Neuropsychology?f_ri=7648","nofollow":true},{"id":1750,"name":"Assessment","url":"https://www.academia.edu/Documents/in/Assessment?f_ri=7648","nofollow":true},{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":18174,"name":"Language","url":"https://www.academia.edu/Documents/in/Language?f_ri=7648"},{"id":46858,"name":"Memory","url":"https://www.academia.edu/Documents/in/Memory?f_ri=7648"},{"id":52176,"name":"Brain Mapping","url":"https://www.academia.edu/Documents/in/Brain_Mapping?f_ri=7648"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=7648"},{"id":97764,"name":"Neuropsychological Assessment","url":"https://www.academia.edu/Documents/in/Neuropsychological_Assessment?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":509029,"name":"Functional Neuroimaging","url":"https://www.academia.edu/Documents/in/Functional_Neuroimaging?f_ri=7648"},{"id":1126675,"name":"Memory Testing","url":"https://www.academia.edu/Documents/in/Memory_Testing?f_ri=7648"},{"id":2467548,"name":"Neuropsychological Tests","url":"https://www.academia.edu/Documents/in/Neuropsychological_Tests?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_73907410 coauthored" data-work_id="73907410" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/73907410/Novel_mutations_in_ATP1A3_associated_with_catastrophic_early_life_epilepsy_episodic_prolonged_apnea_and_postnatal_microcephaly">Novel mutations in ATP1A3 associated with catastrophic early life epilepsy, episodic prolonged apnea, and postnatal microcephaly</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objective Mutations of ATP1A3 have been associated with rapid onset dystonia-parkinsonism and more recently with alternating hemiplegia of childhood. Here we report one child with catastrophic early life epilepsy and shortened survival,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_73907410" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objective Mutations of ATP1A3 have been associated with rapid onset dystonia-parkinsonism and more recently with alternating hemiplegia of childhood. Here we report one child with catastrophic early life epilepsy and shortened survival, and another with epilepsy, episodic prolonged apnea, postnatal microcephaly, and severe developmental disability. Novel heterozygous mutations (p.Gly358Val and p.Ile363Asn) were identified in ATP1A3 in these children.Methods Subjects underwent next-generation sequencing under a research protocol. Clinical data were collected retrospectively. The biochemical effects of the mutations on ATP1A3 protein function were investigated. Postmortem neuropathologic specimens from control and affected subjects were studied.ResultsThe mutations localized to the P domain of the Na,K-ATPase α3 protein, and resulted in significant reduction of Na,K-ATPase activity in vitro. We demonstrate in both control human brain tissue and that from the subject with the p.Gly358V...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73907410" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="15967fac20102eac897c45273bd58ffa" rel="nofollow" data-download="{"attachment_id":83824582,"asset_id":73907410,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/83824582/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="217813938" href="https://washington.academia.edu/HannahTully">Hannah Tully</a><script data-card-contents-for-user="217813938" type="text/json">{"id":217813938,"first_name":"Hannah","last_name":"Tully","domain_name":"washington","page_name":"HannahTully","display_name":"Hannah Tully","profile_url":"https://washington.academia.edu/HannahTully?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-73907410">+1</span><div class="hidden js-additional-users-73907410"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/GhoneimDalia">Dalia Ghoneim</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-73907410'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-73907410').html(); 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Here we report one child with catastrophic early life epilepsy and shortened survival, and another with epilepsy, episodic prolonged apnea, postnatal microcephaly, and severe developmental disability. Novel heterozygous mutations (p.Gly358Val and p.Ile363Asn) were identified in ATP1A3 in these children.Methods Subjects underwent next-generation sequencing under a research protocol. Clinical data were collected retrospectively. The biochemical effects of the mutations on ATP1A3 protein function were investigated. Postmortem neuropathologic specimens from control and affected subjects were studied.ResultsThe mutations localized to the P domain of the Na,K-ATPase α3 protein, and resulted in significant reduction of Na,K-ATPase activity in vitro. We demonstrate in both control human brain tissue and that from the subject with the p.Gly358V...","downloadable_attachments":[{"id":83824582,"asset_id":73907410,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":217813938,"first_name":"Hannah","last_name":"Tully","domain_name":"washington","page_name":"HannahTully","display_name":"Hannah Tully","profile_url":"https://washington.academia.edu/HannahTully?f_ri=7648","photo":"/images/s65_no_pic.png"},{"id":218770617,"first_name":"Dalia","last_name":"Ghoneim","domain_name":"independent","page_name":"GhoneimDalia","display_name":"Dalia Ghoneim","profile_url":"https://independent.academia.edu/GhoneimDalia?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648","nofollow":true},{"id":12981,"name":"Enzyme Inhibitors","url":"https://www.academia.edu/Documents/in/Enzyme_Inhibitors?f_ri=7648","nofollow":true},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=7648","nofollow":true},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=7648"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=7648"},{"id":228487,"name":"Epilepsia","url":"https://www.academia.edu/Documents/in/Epilepsia?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":620070,"name":"Transfection","url":"https://www.academia.edu/Documents/in/Transfection?f_ri=7648"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=7648"},{"id":1423078,"name":"Nervous System Diseases","url":"https://www.academia.edu/Documents/in/Nervous_System_Diseases?f_ri=7648"},{"id":1598058,"name":"Glutamate decarboxylase","url":"https://www.academia.edu/Documents/in/Glutamate_decarboxylase?f_ri=7648"},{"id":2085586,"name":"Ouabain","url":"https://www.academia.edu/Documents/in/Ouabain?f_ri=7648"},{"id":2482159,"name":"DNA mutational analysis","url":"https://www.academia.edu/Documents/in/DNA_mutational_analysis?f_ri=7648"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=7648"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_55960427" data-work_id="55960427" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/55960427/Stimulus_induced_drop_episodes_in_Coffin_Lowry_syndrome">Stimulus-induced drop episodes in Coffin–Lowry syndrome</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objective. Coffin-Lowry syndrome (CLS) is a rare disorder characterized by moderate to severe mental retardation, facial dysmorphism, tapering digits, and skeletal deformity. Paroxysmal drop attacks occur in patients with CLS,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_55960427" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objective. Coffin-Lowry syndrome (CLS) is a rare disorder characterized by moderate to severe mental retardation, facial dysmorphism, tapering digits, and skeletal deformity. Paroxysmal drop attacks occur in patients with CLS, characterized by sudden loss of muscle tone induced by unexpected tactile or auditory stimuli. Our objective is to characterize these attacks better using neurophysiologic studies. Methods. We report 2 teenage boys with CLS and stimulus-induced drop episodes (SIDEs). Simultaneous surface electromyogram (EMG) and video electroencephalogram were performed during SIDEs on our 2 patients. Results. Both patients had SIDEs stimulated by a loud noise, unexpected light touch stimulation, or visual threat that were characterized by abrupt episodes of complete or partial loss of lower extremity tone. These events were not associated with impairment of consciousness, and immediate recovery was noted. Simultaneous surface EMG and video electroencephalogram revealed no epileptiform discharges in either patient. In the first patient, after unexpected tactile or auditory stimulation, tonic EMG activity in paraspinal muscles was lost briefly, similar to that seen in cataplexy. In the second patient, at 6 years of age, sudden nonepileptic drop episodes were induced by an unexpected tactile, auditory, or visual stimulation. At 11 years of age, his episodes had changed to brief myoclonic jerk and tonic spasm that were triggered by unexpected tactile and auditory stimuli. An increase in tonic EMG activity occurred during the attacks, consistent with hyperekplexia. Conclusions. Our data suggest that SIDEs in CLS are a heterogeneous group of nonepileptic events that may manifest features of both cataplexy and hyperekplexia, even in the same patient. Pediatrics 2003;111:e197-e202.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/55960427" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="942861f2c409569075b7e02e3943fd07" rel="nofollow" data-download="{"attachment_id":71585536,"asset_id":55960427,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/71585536/download_file?st=MTc0MDIxODI2Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="172138752" href="https://unistra.academia.edu/AndreHANAUER">Andre HANAUER</a><script data-card-contents-for-user="172138752" type="text/json">{"id":172138752,"first_name":"Andre","last_name":"HANAUER","domain_name":"unistra","page_name":"AndreHANAUER","display_name":"Andre HANAUER","profile_url":"https://unistra.academia.edu/AndreHANAUER?f_ri=7648","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_55960427 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="55960427"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 55960427, container: ".js-paper-rank-work_55960427", }); 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$(".js-view-count[data-work-id=55960427]").text(description); $(".js-view-count-work_55960427").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_55960427").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="55960427"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="156" rel="nofollow" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="631" rel="nofollow" href="https://www.academia.edu/Documents/in/Pediatrics">Pediatrics</a>, <script data-card-contents-for-ri="631" type="text/json">{"id":631,"name":"Pediatrics","url":"https://www.academia.edu/Documents/in/Pediatrics?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7648" rel="nofollow" href="https://www.academia.edu/Documents/in/Epilepsy">Epilepsy</a>, <script data-card-contents-for-ri="7648" type="text/json">{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10904" rel="nofollow" href="https://www.academia.edu/Documents/in/Electroencephalography">Electroencephalography</a><script data-card-contents-for-ri="10904" type="text/json">{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=55960427]'), work: {"id":55960427,"title":"Stimulus-induced drop episodes in Coffin–Lowry syndrome","created_at":"2021-10-06T07:12:09.023-07:00","url":"https://www.academia.edu/55960427/Stimulus_induced_drop_episodes_in_Coffin_Lowry_syndrome?f_ri=7648","dom_id":"work_55960427","summary":"Objective. Coffin-Lowry syndrome (CLS) is a rare disorder characterized by moderate to severe mental retardation, facial dysmorphism, tapering digits, and skeletal deformity. Paroxysmal drop attacks occur in patients with CLS, characterized by sudden loss of muscle tone induced by unexpected tactile or auditory stimuli. Our objective is to characterize these attacks better using neurophysiologic studies. Methods. We report 2 teenage boys with CLS and stimulus-induced drop episodes (SIDEs). Simultaneous surface electromyogram (EMG) and video electroencephalogram were performed during SIDEs on our 2 patients. Results. Both patients had SIDEs stimulated by a loud noise, unexpected light touch stimulation, or visual threat that were characterized by abrupt episodes of complete or partial loss of lower extremity tone. These events were not associated with impairment of consciousness, and immediate recovery was noted. Simultaneous surface EMG and video electroencephalogram revealed no epileptiform discharges in either patient. In the first patient, after unexpected tactile or auditory stimulation, tonic EMG activity in paraspinal muscles was lost briefly, similar to that seen in cataplexy. In the second patient, at 6 years of age, sudden nonepileptic drop episodes were induced by an unexpected tactile, auditory, or visual stimulation. At 11 years of age, his episodes had changed to brief myoclonic jerk and tonic spasm that were triggered by unexpected tactile and auditory stimuli. An increase in tonic EMG activity occurred during the attacks, consistent with hyperekplexia. Conclusions. Our data suggest that SIDEs in CLS are a heterogeneous group of nonepileptic events that may manifest features of both cataplexy and hyperekplexia, even in the same patient. Pediatrics 2003;111:e197-e202.","downloadable_attachments":[{"id":71585536,"asset_id":55960427,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":172138752,"first_name":"Andre","last_name":"HANAUER","domain_name":"unistra","page_name":"AndreHANAUER","display_name":"Andre HANAUER","profile_url":"https://unistra.academia.edu/AndreHANAUER?f_ri=7648","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=7648","nofollow":true},{"id":631,"name":"Pediatrics","url":"https://www.academia.edu/Documents/in/Pediatrics?f_ri=7648","nofollow":true},{"id":7648,"name":"Epilepsy","url":"https://www.academia.edu/Documents/in/Epilepsy?f_ri=7648","nofollow":true},{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=7648","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=7648"},{"id":68431,"name":"Noise","url":"https://www.academia.edu/Documents/in/Noise?f_ri=7648"},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=7648"},{"id":170918,"name":"Electromyography","url":"https://www.academia.edu/Documents/in/Electromyography?f_ri=7648"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=7648"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=7648"},{"id":468209,"name":"Videotape Recording","url":"https://www.academia.edu/Documents/in/Videotape_Recording?f_ri=7648"},{"id":1454403,"name":"Syncope","url":"https://www.academia.edu/Documents/in/Syncope?f_ri=7648"},{"id":1531243,"name":"Cataplexy","url":"https://www.academia.edu/Documents/in/Cataplexy?f_ri=7648"},{"id":2428413,"name":"Acoustic Stimulation","url":"https://www.academia.edu/Documents/in/Acoustic_Stimulation?f_ri=7648"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences?f_ri=7648"},{"id":3063328,"name":"Coffin-lowry Syndrome","url":"https://www.academia.edu/Documents/in/Coffin-lowry_Syndrome?f_ri=7648"},{"id":3763225,"name":"Medical and Health 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