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<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="EI2OkQLVQokrqI5fqS-PplwoLgAeLQtRRSez3SRodCQ99IK2yamLBS2HhM3sAP09WuUfRL9RcuXmaR-iasOn6w" /> <meta name="citation_title" content="Stiripentol. A novel antiepileptic drug" /> <meta name="citation_publication_date" content="2005/01/01" /> <meta name="citation_journal_title" content="Pharmacological reports : PR" /> <meta name="citation_author" content="Stanisław Czuczwar" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/66686381/Stiripentol_A_novel_antiepileptic_drug" /> <meta name="twitter:title" content="Stiripentol. A novel antiepileptic drug" /> <meta name="twitter:description" content="Epilepsy is one of the most widespread pathologies of human brain, affecting approximately 1% of world population. Despite the development of new methods of seizure control, chronic administration of antiepileptic drugs (AEDs) remains the treatment" /> <meta name="twitter:image" content="http://a.academia-assets.com/images/twitter-card.jpeg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/66686381/Stiripentol_A_novel_antiepileptic_drug" /> <meta property="og:title" content="Stiripentol. A novel antiepileptic drug" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="Epilepsy is one of the most widespread pathologies of human brain, affecting approximately 1% of world population. Despite the development of new methods of seizure control, chronic administration of antiepileptic drugs (AEDs) remains the treatment" /> <meta property="article:author" content="https://independent.academia.edu/Stanis%C5%82awCzuczwar" /> <meta name="description" content="Epilepsy is one of the most widespread pathologies of human brain, affecting approximately 1% of world population. Despite the development of new methods of seizure control, chronic administration of antiepileptic drugs (AEDs) remains the treatment" /> <title>(PDF) Stiripentol: A New Approach for Epilepsy</title> <link rel="canonical" href="https://www.academia.edu/66686381/Stiripentol_A_novel_antiepileptic_drug" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '29cbb9485f79f49ca3eb38b6f0905739256f19a4'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1740270264000); window.Aedu.timeDifference = new Date().getTime() - 1740270264000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Epilepsy is one of the most widespread pathologies of human brain, affecting approximately 1% of world population. Despite the development of new methods of seizure control, chronic administration of antiepileptic drugs (AEDs) remains the treatment of choice. Nevertheless, pharmacotherapy is not always effective. In the case of single drug treatment, the number of non-responding patients is as high as 30%. Moreover, chronic medication with currently available AEDs may result in severe side-effects and undesired drug interactions. That is why in recent years intensive research has been carried out aiming at the development of new therapeutic strategies in epilepsy. The goal of this review is to assemble current literature data on stiripentol (STP), a novel anticonvulsant unrelated to any other AEDs. STP potentiates central gamma-aminobutyric acid (GABA) transmission and is characterized by nonlinear pharmacokinetics and inhibition of liver microsomal enzymes. STP has proved its antic...","author":[{"@context":"https://schema.org","@type":"Person","name":"Stanisław Czuczwar","url":"https://independent.academia.edu/Stanis%C5%82awCzuczwar"}],"contributor":[],"dateCreated":"2021-12-31","dateModified":"2025-02-01","datePublished":"2005-01-01","headline":"Stiripentol. A novel antiepileptic drug","image":"https://attachments.academia-assets.com/77781786/thumbnails/1.jpg","inLanguage":"en","keywords":["Epilepsy","Medicine","Brain","Gamma-Aminobutyric Acid","Pharmacology and pharmaceutical sciences"],"publication":"Pharmacological reports : PR","publisher":{"@context":"https://schema.org","@type":"Organization","name":"Pharmacological reports : PR"},"sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}],"thumbnailUrl":"https://attachments.academia-assets.com/77781786/thumbnails/1.jpg","url":"https://www.academia.edu/66686381/Stiripentol_A_novel_antiepileptic_drug"}</script><style type="text/css">@media(max-width: 567px){:root{--token-mode: Rebrand;--dropshadow: 0 2px 4px 0 #22223340;--primary-brand: #0645b1;--error-dark: #b60000;--success-dark: #05b01c;--inactive-fill: #ebebee;--hover: #0c3b8d;--pressed: #082f75;--button-primary-fill-inactive: #ebebee;--button-primary-fill: #0645b1;--button-primary-text: 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{"work":{"id":66686381,"created_at":"2021-12-31T01:34:26.067-08:00","from_world_paper_id":189992488,"updated_at":"2025-02-01T12:32:20.669-08:00","_data":{"abstract":"Epilepsy is one of the most widespread pathologies of human brain, affecting approximately 1% of world population. Despite the development of new methods of seizure control, chronic administration of antiepileptic drugs (AEDs) remains the treatment of choice. Nevertheless, pharmacotherapy is not always effective. In the case of single drug treatment, the number of non-responding patients is as high as 30%. Moreover, chronic medication with currently available AEDs may result in severe side-effects and undesired drug interactions. That is why in recent years intensive research has been carried out aiming at the development of new therapeutic strategies in epilepsy. The goal of this review is to assemble current literature data on stiripentol (STP), a novel anticonvulsant unrelated to any other AEDs. STP potentiates central gamma-aminobutyric acid (GABA) transmission and is characterized by nonlinear pharmacokinetics and inhibition of liver microsomal enzymes. STP has proved its antic...","publisher":"Pharmacological reports : PR","ai_title_tag":"Stiripentol: A New Approach for Epilepsy","publication_date":"2005,,","publication_name":"Pharmacological reports : PR"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Stiripentol. A novel antiepileptic drug","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [45722389]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":77781786,"attachmentType":"pdf"}"><img alt="First page of “Stiripentol. A novel antiepileptic drug”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/77781786/mini_magick20211231-25428-bmpp85.png?1640943307" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Stiripentol. A novel antiepileptic drug</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="45722389" href="https://independent.academia.edu/Stanis%C5%82awCzuczwar"><img alt="Profile image of Stanisław Czuczwar" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Stanisław Czuczwar</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2005, Pharmacological reports : PR</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">7 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 66686381; const worksViewsPath = "/v0/works/views?subdomain_param=api&work_ids%5B%5D=66686381"; const getWorkViews = async (workId) => { const response = await fetch(worksViewsPath); if (!response.ok) { throw new Error('Failed to load work views'); } const data = await response.json(); return data.views[workId]; }; // Get the view count for the work - we send this immediately rather than waiting for // the DOM to load, so it can be available as soon as possible (but without holding up // the backend or other resource requests, because it's a bit expensive and not critical). const viewCount = await getWorkViews(workId); const updateViewCount = (viewCount) => { try { const viewCountNumber = parseInt(viewCount, 10); if (viewCountNumber === 0) { // Remove the whole views element if there are zero views. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); return; } const commaizedViewCount = viewCountNumber.toLocaleString(); const viewCountBody = document.getElementById('work-metadata-view-count'); if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Epilepsy is one of the most widespread pathologies of human brain, affecting approximately 1% of world population. Despite the development of new methods of seizure control, chronic administration of antiepileptic drugs (AEDs) remains the treatment of choice. Nevertheless, pharmacotherapy is not always effective. In the case of single drug treatment, the number of non-responding patients is as high as 30%. Moreover, chronic medication with currently available AEDs may result in severe side-effects and undesired drug interactions. That is why in recent years intensive research has been carried out aiming at the development of new therapeutic strategies in epilepsy. The goal of this review is to assemble current literature data on stiripentol (STP), a novel anticonvulsant unrelated to any other AEDs. STP potentiates central gamma-aminobutyric acid (GABA) transmission and is characterized by nonlinear pharmacokinetics and inhibition of liver microsomal enzymes. 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For nearly 30% of people with epilepsy, seizures are not controlled by current treatments. Stiripentol is a new antiepileptic drug (AED) that was developed in France and was approved by the European Medicines Agency (EMA) in 2007 for the treatment of Dravet syndrome as adjunctive therapy with valproate and clobazam, with promising effects. Objectives To evaluate the efficacy and tolerability of stiripentol as add-on treatment for patients with focal refractory epilepsy who are taking AEDs. Search methods We searched the Cochrane Epilepsy Group Specialised Register (10 August 2015), the Cochrane Central Register of Controlled Trials (CENTRAL; August 2015, Issue 8)and MEDLINE (Ovid) (1946 to 10 August 2015). We contacted Biocodex (the manufacturer of stiripentol) and epilepsy experts to identify published, unpublished and ongoing trials. Selection criteria Randomised controlled add-on trials of stiripentol in patients with focal refractory epilepsy. Data collection and analysis Review authors independently selected trials for inclusion and extracted data. Outcomes investigated included 50%or greater reduction in seizure frequency, seizure freedom, adverse effects, treatment withdrawal and changes in quality of life. Main results On the basis of our selection criteria, we included no new studies in the present review. However, we did include one study from the earlier review (32 children with focal epilepsy). This study adopted a ’responder enriched’ design and found no clear evidence of a reduction in seizure frequency (≥50%seizure reduction) (risk ratio (RR) 1.51, 95%confidence interval (CI) 0.81 to 2.82) nor evidence of seizure freedom (RR 1.18, 95% CI 0.31 to 4.43) when add-on stiripentol was compared with placebo. Stiripentol led to a greater risk of adverse effects considered as a whole (RR 2.65, 95% CI 1.08 to 6.47). When specific adverse events were considered, confidence intervals were very wide and showed the possibility of substantial increases and small reductions in risks of neurological (RR 2.65, 95% CI 0.88 to 8.01) or gastrointestinal adverse effects (RR 11.56, 95% CI 0.71 to 189.36). Researchers noted no clear reduction in the risk of study withdrawal (RR 0.66, 95% CI 0.30 to 1.47), which was high in both groups (35.0% in add-on placebo and 53.3% in stiripentol group). The external validity of this study was limited because only responders to stiripentol (i.e. patients experiencing a ≥ 50% decrease in seizure frequency compared with baseline) were included in the randomised add-on placebo-controlled doubleblind phase. Furthermore, carry-over and withdrawal effects probably influenced outcomes related to seizure frequency. Very limited information derived from the only included study shows that adverse effects considered as a whole seemed to occur significantly more often with add-on stiripentol than with add-on placebo. Authors’ conclusions Since the last version of this review was published, we have found no new studies. Hence, we have made no changes to the conclusions of this update as presented in the initial review. We can draw no conclusions to support the use of stiripentol as add-on treatment for focal refractory epilepsy. Additional large, randomised, well-conducted trials are needed.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Stiripentol for focal refractory epilepsy (Review)","attachmentId":39360632,"attachmentType":"pdf","work_url":"https://www.academia.edu/17168615/Stiripentol_for_focal_refractory_epilepsy_Review_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/17168615/Stiripentol_for_focal_refractory_epilepsy_Review_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="104159953" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/104159953/Stiripentol_a_Putative_Antiepileptic_Drug_Enhances_the_Duration_of_Opening_of_GABAA_Receptor_Channels">Stiripentol, a Putative Antiepileptic Drug, Enhances the Duration of Opening of GABAA-Receptor Channels</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="56766660" href="https://independent.academia.edu/YehezkelBenari">Yehezkel Ben-ari</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Epilepsia, 2006</p><p class="ds-related-work--abstract ds2-5-body-sm">Stiripentol (STP) is currently an efficient drug for add-on therapy in infantile epilepsies because it improves the efficacy of antiepileptic drugs (AEDs) through its potent inhibition of liver cytochromes P450. In addition, STP directly reduces seizures in several animal models of epilepsy, suggesting that it might also have anticonvulsive effects of its own. However, its underlying mechanisms of action are unknown. Methods: We examined the interactions of STP with γaminobutyric acid (GABA) transmission by using patch-clamp methods in CA3 pyramidal neurons in the neonatal rat. Results: STP markedly increased miniature inhibitory postsynaptic current (mIPSC) decay-time constant in a concentrationdependent manner. The prolongation of mIPSC duration does not result from an interaction with GABA transporters because it persisted in the presence of GAT-1 inhibitors (SKF-89976A and NO-711). An interaction with benzodiazepine or neurosteroid binding sites also was excluded because STP-mediated increase of decay time was still observed when these sites were initially saturated (by clobazam, zolpidem, or pregnanolone) or blocked (by flumazenil or dehydroepiandrosterone sulfate), respectively. In contrast, saturating barbiturate sites with pentobarbital clearly occluded this effect of STP, suggesting that STP and barbiturates interact at the same locus. This was directly confirmed by using outside-out patches, because STP increased the duration and not the frequency of opening of GABA A channels. Conclusions: At clinically relevant concentrations, STP enhances central GABA transmission through a barbiturate-like effect, suggesting that STP should possess an antiepileptic effect by itself.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Stiripentol, a Putative Antiepileptic Drug, Enhances the Duration of Opening of GABAA-Receptor Channels","attachmentId":103959908,"attachmentType":"pdf","work_url":"https://www.academia.edu/104159953/Stiripentol_a_Putative_Antiepileptic_Drug_Enhances_the_Duration_of_Opening_of_GABAA_Receptor_Channels","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/104159953/Stiripentol_a_Putative_Antiepileptic_Drug_Enhances_the_Duration_of_Opening_of_GABAA_Receptor_Channels"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="13383869" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13383869/Stiripentol_for_focal_refractory_epilepsy">Stiripentol for focal refractory epilepsy</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32610748" href="https://univr.academia.edu/FrancescoBrigo">Francesco Brigo</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Reviews, 1996</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Stiripentol for focal refractory epilepsy","attachmentId":45400504,"attachmentType":"pdf","work_url":"https://www.academia.edu/13383869/Stiripentol_for_focal_refractory_epilepsy","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13383869/Stiripentol_for_focal_refractory_epilepsy"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="13701246" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13701246/Concentrations_of_Stiripentol_in_Children_and_Adults_With_Epilepsy">Concentrations of Stiripentol in Children and Adults With Epilepsy</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32835928" href="https://independent.academia.edu/ElisabethKornmerker">Elisabeth Korn-merker</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Therapeutic Drug Monitoring, 2012</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Stiripentol (STP) was approved as an orphan drug in 2007 in Europe as adjunctive therapy with valproic acid (VPA) and clobazam (CLB) for Dravet syndrome. Dravet syndrome is a highly pharmacoresistant form of epilepsy, which starts in early childhood. Data about STP pharmacokinetics and interactions are still limited and in part inconsistent. The aim of our study was to analyze the effect of age, gender, daily STP dose per body weight (milligrams per kilogram), VPA, CLB, and enzyme-inducing antiepileptic drugs on STP concentration-to-dose ratio (CDR), STP clearance, and STP trough concentrations.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Concentrations of Stiripentol in Children and Adults With Epilepsy","attachmentId":45038351,"attachmentType":"pdf","work_url":"https://www.academia.edu/13701246/Concentrations_of_Stiripentol_in_Children_and_Adults_With_Epilepsy","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13701246/Concentrations_of_Stiripentol_in_Children_and_Adults_With_Epilepsy"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="107266692" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/107266692/Stiripentol_add_on_therapy_for_focal_refractory_epilepsy">Stiripentol add-on therapy for focal refractory epilepsy</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32610748" href="https://univr.academia.edu/FrancescoBrigo">Francesco Brigo</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Cochrane database of systematic reviews, 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">This is an updated version of the Cochrane review last published in 2015 (Issue 10). For nearly 30% of people with epilepsy, seizures are not controlled by current treatments. Stiripentol is a new antiepileptic drug (AED) that was developed in France and was approved by the European Medicines Agency (EMA) in 2007 for the treatment of Dravet syndrome as an adjunctive therapy with valproate and clobazam, with promising effects. To evaluate the efficacy and tolerability of stiripentol as add-on treatment for people with focal refractory epilepsy who are taking AEDs. For the latest update, we searched the following databases on 21 August 2017: Cochrane Epilepsy Specialized Register, CENTRAL , MEDLINE, ClinicalTrials.gov, and the WHO International Clinical Trials Registry Platform (ICTRP). We contacted Biocodex (the manufacturer of stiripentol) and epilepsy experts to identify published, unpublished and ongoing trials. Randomised, controlled, add-on trials of stiripentol in people with f...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Stiripentol add-on therapy for focal refractory epilepsy","attachmentId":105982883,"attachmentType":"pdf","work_url":"https://www.academia.edu/107266692/Stiripentol_add_on_therapy_for_focal_refractory_epilepsy","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/107266692/Stiripentol_add_on_therapy_for_focal_refractory_epilepsy"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="111934487" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/111934487/Stiripentol_add_on_therapy_for_drug_resistant_focal_epilepsy">Stiripentol add-on therapy for drug-resistant focal epilepsy</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5303704" href="https://cardiff.academia.edu/StanleyIgwe">Stanley Igwe</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Cochrane library, 2022</p><p class="ds-related-work--abstract ds2-5-body-sm">Editorial group: Cochrane Epilepsy Group. Publication status and date: New search for studies and content updated (no change to conclusions), published in Issue 5, 2020.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Stiripentol add-on therapy for drug-resistant focal epilepsy","attachmentId":109322725,"attachmentType":"pdf","work_url":"https://www.academia.edu/111934487/Stiripentol_add_on_therapy_for_drug_resistant_focal_epilepsy","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/111934487/Stiripentol_add_on_therapy_for_drug_resistant_focal_epilepsy"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="13978042" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13978042/Characterization_of_the_Anticonvulsant_Behavioral_and_Pharmacokinetic_Interaction_Profiles_of_Stiripentol_in_Combination_with_Clonazepam_Ethosuximide_Phenobarbital_and_Valproate_Using_Isobolographic_Analysis">Characterization of the Anticonvulsant, Behavioral and Pharmacokinetic Interaction Profiles of Stiripentol in Combination with Clonazepam, Ethosuximide, Phenobarbital, and Valproate Using Isobolographic Analysis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33071239" href="https://umlub.academia.edu/JarogniewLuszczki">Jarogniew Luszczki</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33022530" href="https://ucl.academia.edu/PhilipPatsalos">Philip Patsalos</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Epilepsia, 2006</p><p class="ds-related-work--abstract ds2-5-body-sm">Purpose: Isobolographic analysis was used to characterize the interactions between stiripentol (STP) and clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)induced clonic seizures in mice.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Characterization of the Anticonvulsant, Behavioral and Pharmacokinetic Interaction Profiles of Stiripentol in Combination with Clonazepam, Ethosuximide, Phenobarbital, and Valproate Using Isobolographic Analysis","attachmentId":44743350,"attachmentType":"pdf","work_url":"https://www.academia.edu/13978042/Characterization_of_the_Anticonvulsant_Behavioral_and_Pharmacokinetic_Interaction_Profiles_of_Stiripentol_in_Combination_with_Clonazepam_Ethosuximide_Phenobarbital_and_Valproate_Using_Isobolographic_Analysis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13978042/Characterization_of_the_Anticonvulsant_Behavioral_and_Pharmacokinetic_Interaction_Profiles_of_Stiripentol_in_Combination_with_Clonazepam_Ethosuximide_Phenobarbital_and_Valproate_Using_Isobolographic_Analysis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="23992249" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/23992249/Interactions_of_stiripentol_with_clobazam_and_valproate_in_the_mouse_maximal_electroshock_induced_seizure_model">Interactions of stiripentol with clobazam and valproate in the mouse maximal electroshock-induced seizure model</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33022530" href="https://ucl.academia.edu/PhilipPatsalos">Philip Patsalos</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Epilepsy Research, 2010</p><p class="ds-related-work--abstract ds2-5-body-sm">In conclusion, the additive interaction between STP and CLB was associated with a concurrent pharmacokinetic interaction and these data may explain the clinical efficacy seen with this combination. In contrast, the antagonism between STP and VPA was surprising since synergism is observed clinically.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Interactions of stiripentol with clobazam and valproate in the mouse maximal electroshock-induced seizure model","attachmentId":44380655,"attachmentType":"pdf","work_url":"https://www.academia.edu/23992249/Interactions_of_stiripentol_with_clobazam_and_valproate_in_the_mouse_maximal_electroshock_induced_seizure_model","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/23992249/Interactions_of_stiripentol_with_clobazam_and_valproate_in_the_mouse_maximal_electroshock_induced_seizure_model"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="125115251" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/125115251/Extending_the_use_of_stiripentol_to_other_epileptic_syndromes_A_case_of_PCDH19_related_epilepsy">Extending the use of stiripentol to other epileptic syndromes: A case of PCDH19-related epilepsy</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="44782085" href="https://techstamps.academia.edu/MarinaTrivisano">Marina Trivisano</a></div><p class="ds-related-work--metadata ds2-5-body-xs">European Journal of Paediatric Neurology, 2015</p><p class="ds-related-work--abstract ds2-5-body-sm">Stiripentol is an antiepileptic drug (AED) approved by the European Medicines Agency for the treatment of Dravet Syndrome (DS) as adjunct treatment with valproate and clobazam. PCDH19-related epilepsy is an emerging epileptic syndrome characterized by the occurrence of epilepsy in female patients associated with mental retardation and autistic features in most cases. It shares many features with DS: age of onset, normal development before the onset, fever sensitivity, cognitive impairment during the time, drug-resistance. Basing on the numerous similarities between DS and PCDH19-related epilepsy, we tried stiripentol in a nine and half year old female patient with PCDH19-related resistant epilepsy, as add-on treatment to valproate and clobazam. It had a surprising efficacy as the patient had a two years and ten months seizure free period, as never in her epilepsy history. Up to date, clinical trials of stiripentol have been always focused on DS. The delineation of new epileptic syndromes, as PCDH19-related epilepsy, opens new scenarios to the utilization of this AED. This case report is suggestive of a good response of PCDH19-related Epilepsy to stiripentol. However further cases and above all clinical trials are necessary to confirm this result.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Extending the use of stiripentol to other epileptic syndromes: A case of PCDH19-related epilepsy","attachmentId":119216356,"attachmentType":"pdf","work_url":"https://www.academia.edu/125115251/Extending_the_use_of_stiripentol_to_other_epileptic_syndromes_A_case_of_PCDH19_related_epilepsy","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/125115251/Extending_the_use_of_stiripentol_to_other_epileptic_syndromes_A_case_of_PCDH19_related_epilepsy"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="14279716" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14279716/Design_and_synthesis_of_novel_stiripentol_analogues_as_potential_anticonvulsants">Design and synthesis of novel stiripentol analogues as potential anticonvulsants</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42522186" href="https://independent.academia.edu/AidaElAzzouny">Aida El-Azzouny</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33208240" href="https://su-se.academia.edu/MohamedAbdelrehim">Mohamed Abdel-Rehim</a></div><p class="ds-related-work--metadata ds2-5-body-xs">European Journal of Medicinal Chemistry, 2012</p><p class="ds-related-work--abstract ds2-5-body-sm">A series of stiripentol (STP) analogues namely, 2-[(1E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ylidene]-N-(aryl/H)hydrazinecarboxamides 7aeh, (AE)-(5RS)-N-(aryl/H)-(1,3-benzodioxol-5-yl)-3-tertbutyl-4,5-dihydro-1H-pyrazole-1-carboxamides (AE)-8aeh, and (AE)-[(5RS)-(1,3-benzodioxol-5-yl)-3-tertbutyl-4,5-dihydro-1H-pyrazol-1-yl](aryl)methanones (AE)-13aef was synthesized by adopting appropriate synthetic routes and was pharmacologically evaluated in the preliminary anticonvulsant screens. The selected bioactive new chemical entities were subjected to ED 50 determination and neurotoxicity evaluation. The most active congeners are 7h in MES screen and (AE)-13b in scPTZ screen which displayed ED 50 values of 87 and 110 mg/kg, respectively, as compared to that of STP (ED 50 ¼ 277.7 and 115 mg/kg in MES and scPTZ, respectively).</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Design and synthesis of novel stiripentol analogues as potential anticonvulsants","attachmentId":44361835,"attachmentType":"pdf","work_url":"https://www.academia.edu/14279716/Design_and_synthesis_of_novel_stiripentol_analogues_as_potential_anticonvulsants","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/14279716/Design_and_synthesis_of_novel_stiripentol_analogues_as_potential_anticonvulsants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":77781786,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":77781786,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_77781786" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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href="https://www.academia.edu/76329212/Epilepsy_Mechanisms_of_Drug_Action_and_Clinical_Treatment">Epilepsy: Mechanisms of Drug Action and Clinical Treatment</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="1556639" href="https://nih.academia.edu/williamtheodore">william theodore</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Handbook of Contemporary Neuropharmacology, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Epilepsy: Mechanisms of Drug Action and Clinical Treatment","attachmentId":84070291,"attachmentType":"pdf","work_url":"https://www.academia.edu/76329212/Epilepsy_Mechanisms_of_Drug_Action_and_Clinical_Treatment","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" 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href="https://liverpool.academia.edu/GusBaker">Gus Baker</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Neurology, Neurosurgery, and Psychiatry, 2016</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Efficacy and Adverse Effects of Anti Epileptic Drugs","attachmentId":110280551,"attachmentType":"pdf","work_url":"https://www.academia.edu/113280126/Efficacy_and_Adverse_Effects_of_Anti_Epileptic_Drugs","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/113280126/Efficacy_and_Adverse_Effects_of_Anti_Epileptic_Drugs"><span class="ds2-5-text-link__content">View 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href="https://univ-paris5.academia.edu/GerardPons">Gerard Pons</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Lancet, 2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial","attachmentId":45286193,"attachmentType":"pdf","work_url":"https://www.academia.edu/13485203/Stiripentol_in_severe_myoclonic_epilepsy_in_infancy_a_randomised_placebo_controlled_syndrome_dedicated_trial","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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Cavalheiro</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Epilepsy Research, 1995</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effects of conventional antiepileptic drugs in a model of spontaneous recurrent seizures in rats","attachmentId":39894398,"attachmentType":"pdf","work_url":"https://www.academia.edu/18136314/Effects_of_conventional_antiepileptic_drugs_in_a_model_of_spontaneous_recurrent_seizures_in_rats","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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data-entity-id="126333146" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/126333146/Place_of_Newer_Antiepileptic_Drugs_in_the_Treatment_of_Epilepsy">Place of Newer Antiepileptic Drugs in the Treatment of Epilepsy</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="300091279" href="https://independent.academia.edu/Ker%C3%A4nenT">Tapani Keränen</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Drugs, 1993</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Place of Newer Antiepileptic Drugs in the Treatment of 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