Pharmacology | Bio-Techne

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Areas</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-therapeutic-manufacturing" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Therapeutic Manufacturing <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-therapeutic-manufacturing" aria-labelledby="navbarDropdown-therapeutic-manufacturing"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Reagents & Kits<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/reagents/cell-culture-reagents/serum-free-animal-free" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3576">Animal-Free Cell Culture</a> <a href="/reagents/elisa-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/176">ELISA Kits</a> <a 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href="/gmp-products/ruo-to-gmp" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3421">Transition to GMP </a> <a href="/gmp-products/loa-request" class="dropdown-item text-wrap" data-drupal-link-system-path="node/13326">DMF/LOA Request</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Instruments<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/brands/proteinsimple" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3281">ProteinSimple Instruments</a> <a href="/instruments/ice" class="dropdown-item text-wrap" data-drupal-link-system-path="node/256">iCE Maurice</a> <a href="/instruments/imagers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/536">Imagers</a> <a href="/instruments/luminex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/241">Luminex</a> <a href="/instruments/micro-flow-imaging" class="dropdown-item text-wrap" data-drupal-link-system-path="node/526">Micro-Flow Imaging</a> <a href="/instruments/simple-plex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/541">Simple Plex Ella</a> <a href="/instruments/simple-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/521">Simple Western</a> <a href="/instruments/single-cell-dispensers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6361">Single Cell Dispensers</a> <a href="/instruments/single-cell-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/531">Single Cell Western</a> <a href="/instruments" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6731">View All Instruments</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Applications<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a 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aria-labelledby="navbarDropdown-diagnostics"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Controls & Reagents<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/clinical-quality-controls" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7606">Clinical Quality Controls</a> <a href="/diagnostics/molecular-quality-controls" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5596">Molecular Controls</a> <a href="/diagnostics/controls-reagents/rnascope-ish-probe-high-risk-hpv" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5981">RNAscope™ ISH Probe High Risk HPV</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Kits<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/amplidex-genetic-testing-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5581">Genetics</a> <a href="/diagnostics/quantidex-oncology-testing-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5586">Oncology</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Technology<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/exosome" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5486">Exosome Platform</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> OEM Services<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/ivd-assay-development" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10881">IVD Assay Development</a> <a href="/diagnostics/ivd-contract-manufacturing" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7381">IVD Contract Manufacturing</a> <a href="/diagnostics/molecular-quality-controls/oem-and-commercial-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6781">Molecular Diagnostic OEM Services</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Companion Diagnostics<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/companion-diagnostics" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5631">Companion Diagnostics Services</a> <a href="/diagnostics/companion-diagnostics/multiomics" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10616">Multiomics Platform</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-services" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Services <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-services" aria-labelledby="navbarDropdown-services"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Custom Quotes<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/bulk-quotes" class="dropdown-item text-wrap" data-drupal-link-system-path="services/bulk-quotes">Bulk Quote Discounts</a> <a href="/services/custom-formulation" class="dropdown-item text-wrap" data-drupal-link-system-path="services/custom-formulation">Custom Formulation Quotes</a> <a href="/reagents/rnascope-ish-technology/probes/custom" class="dropdown-item text-wrap" data-drupal-link-system-path="node/12571">RNAscope Custom Probe Design Quote</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Custom 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Bio-Techne" data-drupal-link-system-path="node/1136">Custom Gene Engineering Services</a> <a href="/services/custom-luminex-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/271">Custom Luminex Services</a> <a href="/services/custom-protein-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1441">Custom Protein Services</a> <a href="/services/custom-simple-plex-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6296">Custom Simple Plex Services</a> <a href="/services/custom-targeted-protein-degradation-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/861">Custom Targeted Protein Degradation Services</a> <a href="/services/professional-assay-services-rnascope" class="dropdown-item text-wrap" data-drupal-link-system-path="node/12306">RNAscope Professional Assay Services</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Instrument Services<span 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</div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-resources" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Resources <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-resources" aria-labelledby="navbarDropdown-resources"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Product & Instrument Tools<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/resources/cofa-finder-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/cofa-finder-tool">Certificate of Analysis (COA) Finder Tool</a> <a href="/resources/calculators" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7416">Calculators</a> <a href="/resources/flow-cytometry-panel-builder" class="dropdown-item text-wrap" 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class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:h1_2_2_text_to_media:field_indv_h1"> <div><h1>Pharmacology</h1></div> </div> <div class="field_block:paragraph:h1_2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><p>Pharmacology is the study of how biological systems interact with drugs, and how a drug's action is affected by biological systems. Our small molecule range is comprised of agonists, partial agonists, antagonists, activators, inhibitors, positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs), categorized based on drug target and pharmacological action. We also have a comprehensive range of antibodies and fluorescent probes to label targets.</p></div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:h1_2_2_text_to_media:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/bt-pharmacology-hero-img.png" alt="Pharmacology Proteins Hero Image" fetchpriority="high" > </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> </div> </div> </header> </div> <div id="main" class="container-fluid container-wide"> <div class="row"> <div class="col-md-12"> <div> <div id="block-bio-techne-global-breadcrumbs" class="system_breadcrumb_block"> <nav role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/research-areas">Research Areas</a> </li> <li> Pharmacology </li> </ol> </nav> </div> </div> </div> </div> <main> <section class="section"> <div> <div id="block-bio-techne-global-content" class="system_main_block"> <article> <div> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2>Find Ligands for your Target</h2> <p><em><strong>Search for your target in the search bar above</strong> or </em><em><strong>Browse pharmacology groups below on tocris.com</strong></em></p> <h4><a href="https://www.tocris.com/pharmacology"><strong>Browse Pharmacology Groups at tocris.com</strong></a></h4></div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <h2>Pharmacology Targets</h2> <div class="row card_row"> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="https://www.tocris.com/pharmacology/7-tm-receptors" > </a> <a class="card_title_link" href="https://www.tocris.com/pharmacology/7-tm-receptors" > <h3 class="card_title_htag"> <div><h2>GPCRs</h2></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Our comprehensive range includes agonists, antagonists, partial agonists, DREADD ligands, caged compounds, NAMs, PAMs, biased agonists and fluorescent probes targeting over 30 families of G protein-coupled receptors (GPCRs)/7-Transmembrane receptors (7-TMs), including 5-HT, Glutamate and Dopamine receptors.</p></div> </div> <div class="card-bottom-link"> <div> <a href="https://www.tocris.com/pharmacology/7-tm-receptors" > View Ligands for GPCRs </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="https://www.tocris.com/pharmacology/enzyme-linked-receptors" > </a> <a class="card_title_link" href="https://www.tocris.com/pharmacology/enzyme-linked-receptors" > <h3 class="card_title_htag"> <div><h2>Enzyme-Linked Receptors</h2></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Our expansive collection of small molecule and peptide ligands target both the receptor and enzyme components of the five main types of enzyme-linked receptors, including RTKs, RSTKs, and toll-like receptors.</p> <p> </p></div> </div> <div class="card-bottom-link"> <div> <a href="https://www.tocris.com/pharmacology/enzyme-linked-receptors" > View Ligands for Enzyme-Linked Receptors </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="https://www.tocris.com/pharmacology/enzymes" > </a> <a class="card_title_link" href="https://www.tocris.com/pharmacology/enzymes" > <h3 class="card_title_htag"> <div><h2>Enzymes</h2></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Our expansive enzymes range includes activators, substrates, inhibitors and fluorescent probes targeting over 25 different enzyme families, including ATPases, hydrolases, phosphodiesterases and transferases.</p></div> </div> <div class="card-bottom-link"> <div> <a href="https://www.tocris.com/pharmacology/enzymes" > View Ligands for Enzymes </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <div class="row card_row"> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="https://www.tocris.com/pharmacology/ion-channels" > </a> <a class="card_title_link" href="https://www.tocris.com/pharmacology/ion-channels" > <h3 class="card_title_htag"> <div><h2>Ion Channels</h2></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>We offer an expansive collection of activators, blockers and modulators, PSEMs, and caged compounds that can manipulate several classes of ion channels including calcium channels, ligand-gated ion channels and potassium channels.</p> <p> </p></div> </div> <div class="card-bottom-link"> <div> <a href="https://www.tocris.com/pharmacology/ion-channels" > View Ligands for Ion Channels </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="https://www.tocris.com/pharmacology/nuclear-receptors" > </a> <a class="card_title_link" href="https://www.tocris.com/pharmacology/nuclear-receptors" > <h3 class="card_title_htag"> <div><h2>Nuclear Receptors</h2></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Our range of small molecules and peptides includes agonists, antagonists, modulators and fluorescent probes, which regulates the activity of over 20 types of nuclear receptors, including androgen, estrogen receptors, glucocorticoid and vitamin D receptors.</p></div> </div> <div class="card-bottom-link"> <div> <a href="https://www.tocris.com/pharmacology/nuclear-receptors" > View Ligands for Nuclear Receptors </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="https://www.tocris.com/pharmacology/transporters" > </a> <a class="card_title_link" href="https://www.tocris.com/pharmacology/transporters" > <h3 class="card_title_htag"> <div><h2>Transporters</h2></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Our transporter collection comprises inhibitors, activators, substrates and fluorescent probes, which target glucose, multidrug and neurotransmitter transporters, as well as ion pumps including Na<sup>+</sup>/Ca<sup>2+</sup> exchangers and monocarboxylate transporters.</p></div> </div> <div class="card-bottom-link"> <div> <a href="https://www.tocris.com/pharmacology/transporters" > View Ligands for Transporters </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2>Other Pharmacology Targets</h2> <p>Targets include adenine receptors, antibiotics, antivirals, antioxidants, immunosuppressants, imidazoline receptors and sigma receptors among other targets, as well as miscellaneous compounds. View targets on tocris.com</p> <h4><a href="https://www.tocris.com/pharmacology/other-pharmacology">View Ligands for Other Pharmacology Targets</a></h4></div> </div> </div> <div> <div class="paragraph paragraph--type--_-1-text-to-media mb-4 paragraph--view-mode--default p-3"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--75-25"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:3_1_text_to_media:field_header_2_global"> <div><h2>Rapid and Reproducible Pharmacokinetic Quantification</h2></div> </div> <div class="field_block:paragraph:3_1_text_to_media:field_lg_sngl_frmtd_text_global"> <div><p><a href="/instruments/simple-western">Simple Western™</a> fully automates CE-SDS/cIEF and immunodetection using <a href="/resources/simple-western-antibody-database">conventional Western blot antibodies</a>.  With 96 samples processed overnight, Simple Western will calculate IC/EC50, LOD, LOQ, and more with intra- and inter-assay CVs of <20%, even in complex samples like human serum and tissue homogenates. </p></div> </div> <div class="field_block:paragraph:3_1_text_to_media:field_call_to_action_global"> <a href="/resources/instrument-applications/high-throughput-pharmacokinetic-analysis-with-simple-western" class="btn btn-primary" type="link"> Simple Western Pharmacokinetic Assay </a> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:3_1_text_to_media:field_indv_media"> <div> <a href="https://www.bio-techne.com/resources/instrument-applications/high-throughput-pharmacokinetic-analysis-with-simple-western" title="Simple Western Pharmacokinetic Assay" > <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/bt-simple-western-instruments-hero.png" alt="Simple Western Instruments - Jess & Peggy Sue Hero" loading="lazy" > </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <h2>Related Products</h2> <div class="row card_row"> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/reagents/antibodies" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: #00263A; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/antibodiesSolo05.png" alt="Antibodies" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/reagents/antibodies" > <h3 class="card_title_htag"> <div><h3>Antibodies</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Bio-Techne brands R&D Systems and Novus Biologicals, offer 780,000 antibodies which have been validated in over 25 species for more than 15 applications.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/reagents/antibodies" > Explore Antibodies for your Target </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/applications/electrophysiology" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: #00263A; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/bt-electrophysiology-hero-img.png" alt="Electrophysiology Neuron Hero Image" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/applications/electrophysiology" > <h3 class="card_title_htag"> <div><h3>Electrophysiology</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Electrophysiology techniques measure the electrical current or voltage changes across cells or tissue samples. Electrical activity can be modulated using ion channel modulators, DREADD ligands, PSEMs, GPCR ligands and caged compounds.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/applications/electrophysiology" > View Electrophysiology Products </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/research-areas/targeted-protein-degradation/dtag-atag-degraders" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: #00263A; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/targeted-protein-degradation-frontimg.png" alt="PROTAC degrader molecule in complex with an E3 ligase and the target protein" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/research-areas/targeted-protein-degradation/dtag-atag-degraders" > <h3 class="card_title_htag"> <div><h3>TAG Degraders for Target Validation</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>TAG Degraders, such as dTAG, are a targeted protein degradation approach to target validation, offering a useful alternative to genetic knockdown/knockout methods.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/research-areas/targeted-protein-degradation/dtag-atag-degraders" > Learn More About TAG Degraders </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-3-media-to-text paragraph--view-mode--default mb-4"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--25-75"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_indv_media"> <div> <a href="https://www.bio-techne.com/reagents/tr-fret-and-fp-assay-reagents" title="Learn More About TR-FRET Reagents" > <img src="https://resources.bio-techne.com/bio-techne-assets/images/about/v2_AACR-2024-LP_TR-FRET.png" alt="CoraFluor™ TR-FRET" loading="lazy" > </a> </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_header_2_global"> <div><h3>Explore Target Engagement</h3></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>TR-FRET is a technique widely used in pharmacology for studying ligand-target engagement. Bio-Techne provides a range of fluorescent probes suitable for the development of TR-FRET assays, including CoraFluor™ terbium cryptate FRET donors. </p></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_call_to_action_global"> <a href="/reagents/tr-fret-and-fp-assay-reagents" class="btn btn-primary" type="link"> Learn More About TR-FRET Reagents </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="thin-banner banner_wrapper"> <div class="banner-dark"> <div> <div><h2>Media, Serum, Matrix, and Supplements.</h2></div> <a href="/reagents/cell-culture-reagents" > <button type="button" class="btn btn-primary"> View Cell Culture Reagents </button> </a> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <h2>Pharmacology Resources</h2> <div class="row card_row"> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/resources/calculators" > </a> <a class="card_title_link" href="/resources/calculators" > <h3 class="card_title_htag"> <div><h3>Calculators</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Use our calculators to plan your experiments: </p> <ul> <li><a href="/resources/calculators/molarity-calculator" title="Go to Calculator">Molarity Calculator</a></li> <li><a href="/resources/calculators/dilution-calculator" title="Go to Calculator">Dilution Calculator</a></li> <li><a href="/resources/calculators/reconstitution-calculator" title="Go to Calculator">Reconstitution Calculator</a></li> </ul></div> </div> <div class="card-bottom-link"> <div> <a href="/resources/calculators" > View Calculators </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="https://www.tocris.com/resources/pharmacological-glossary" > </a> <a class="card_title_link" href="https://www.tocris.com/resources/pharmacological-glossary" > <h3 class="card_title_htag"> <div><h3>Pharmacology Glossary </h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><ul> <li>Clear definitions</li> <li>Common equations</li> <li>Defined constants</li> </ul></div> </div> <div class="card-bottom-link"> <div> <a href="https://www.tocris.com/resources/pharmacological-glossary" > Learn more </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="https://www.tocris.com/literature" > </a> <a class="card_title_link" href="https://www.tocris.com/literature" > <h3 class="card_title_htag"> <div><h3>Literature</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><ul> <li>Scientific Posters</li> <li>Scientific Reviews</li> <li>Product Guides</li> <li>Research Bulletins</li> <li>Scientific Meeting Posters</li> </ul></div> </div> <div class="card-bottom-link"> <div> <a href="https://www.tocris.com/literature" > Download or request </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h3>Additional Resources</h3> <ul> </ul></div> </div> </div> <div> <div class="paragraph paragraph--type--columns paragraph--view-mode--default"> <div class="list-grid list-grid-2"> <div class="row"> <div class="col-6 column-group"><h4>Related Links</h4> <ul> <li><a href="/reagents/antibodies/animal-models">Animal Models</a> </li> <li><a href="/reagents/elisa-kits">ELISAs</a></li> <li><a href="/reagents/enzymes">Enzymes</a></li> <li><a href="/research-areas/gpcrs">GPCRs</a></li> <li><a href="/reagents/antibodies/gpcr-antibodies">GPCR Antibodies</a></li> </ul></div> <div class="col-6 column-group"><h4>Useful Resources</h4> <ul> <li><a href="https://gpcrdb.org/" target="_blank">G Protein-Coupled Receptor Database (GPCRDB)</a></li> <li><a href="https://www.guidetopharmacology.org/" target="_blank">IUPHAR/BPS Guide to Pharmacology</a></li> </ul></div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--background-information mb-4 paragraph--view-mode--default"> <div class="row"> <div class="col"> <div> <h3>Background Information </h3> </div> <div> <div id="accordion" class="paragraph paragraph--type--background-about paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#aboutPara-pharmacology-research25" role="button" aria-expanded="false" aria-controls="aboutContents"> <h5>Pharmacology Research</h5> </a> </div> <div class="collapse" id="aboutPara-pharmacology-research25" aria-expanded="false" aria-controls="aboutContents"> <div class="card-body"> <div> <div> <div class="paragraph paragraph--type--full-page-text-with-media mb-4 paragraph--view-mode--default"> <div><h4>Pharmacodynamics and Pharmacokinetics</h4> <p>Pharmacology is split into two main areas, pharmacodynamics and pharmacokinetics. Pharmacodynamics is the study of drugs and their interactions on biological systems. It encompasses drug design and characterization of drugs (e.g. small molecules or peptides). Pharmacokinetics interrogates the effects of biological systems on drug action, studying how a drug is metabolized, absorbed and trafficked into and around the body, as well as the mechanism for drug clearance.</p> <p>The word drug, as used on this website, is intended to mean small molecules or peptides that affect biological function. If drugs have medical applications, they are termed pharmaceuticals.</p> <h4>Pharmacology Product Ranges</h4> <p>Bio-Techne has a long legacy in supporting pharmacology research with high quality small molecules and peptides. Tocris, a Bio-Techne brand, started out as a pharmacology company in 1982, when Professor Jeff Watkins from the <a href="https://www.bristol.ac.uk/" target="_blank">University of Bristol</a>, UK, made glutamate compounds commercially available to the wider scientific community. The first compounds manufactured and sold were <a href="/p/small-molecules-peptides/dl-ap4_0101">DL-AP4 (Catalog # 0101)</a>, a broad spectrum excitatory amino acid (EAA) ligand, and <a href="/p/small-molecules-peptides/d-ap4_0102">D-AP4 (Catalog # 0102)</a> and <a href="/p/small-molecules-peptides/l-ap4_0103">L-AP4 (Catalog # 0103)</a>, DL-AP4’s two isomers.</p> <p>Bio-Techne provides pharmacological research tools for all main research areas including <a href="/research-areas/cancer-profiling">cancer</a>, <a href="/research-areas/cardiovascular-biology">cardiovascular systems</a>, <a href="/research-areas/cell-and-gene-therapy">cell and gene therapy</a>, endocrinology, <a href="/research-areas/immunology">immunology</a>, <a href="/research-areas/neuroscience">neuroscience</a>, pain and inflammation infectious diseases and respiratory systems. Our catalog includes a comprehensive range of gold standard reagents and cutting edge tools such as <a href="https://www.tocris.com/product-type/photoswitchable-ligands" target="_blank">photoswitchable ligands</a>, <a href="https://www.tocris.com/product-type/dreadd-ligands" target="_blank">DREADD ligands</a>, <a href="/search?search_type=products&keywords=PSEM">PSEMs</a>, <a href="/reagents/fluorescent-dyes-probes/fluorescent-probes-stains">fluorescent probes</a>, and <a href="/research-areas/targeted-protein-degradation">PROTAC<sup>®</sup> Degraders</a>. We pride ourselves on being first to market with the latest technologies and tools. Our world class team of PhD qualified scientists, collaborate with industry and academia to ensure we are able to make the latest tools commercially available to scientists in a timely manner.</p> <h4>Pharmacology Resources and Literature</h4> <p>We produce and provide a large range of free <a href="https://www.tocris.com/literature/life-science-posters" target="_blank">scientific posters</a>, <a href="https://www.tocris.com/literature/product-guides" target="_blank">product guides</a>, product listings and <a href="https://www.tocris.com/literature/scientific-reviews" target="_blank">scientific reviews</a> to request or download at tocris.com. These pieces are authored by experts in their field. Two exceptional posters that highlight some of the most recent advances in pharmacological theory are the Allosteric GPCR Pharmacology poster and GPCR Efficacy and Biased Agonism poster, authored by Professor Arthur Christopoulos, Professor Patrick Sexton, David Thal and Denise Wootten. These pieces discuss the latest <a href="/research-areas/gpcrs">GPCR signaling</a> pharmacology and highlights therapeutic applications of ligands with different efficacies as well as biased agonism, PAMS and NAMs.</p> <p>We also have a range of in-house authored scientific meeting posters and scientific bulletins including the popular <a href="https://www.tocris.com/literature/research-bulletins" target="_blank">Chemogenetics bulletin</a>, which gives a clear and concise introduction into chemogenetic methods to manipulate neuronal activity.</p> <p>Finally we have a selection of informative blogs covering a range of research areas including developing chemical probes for <a href="/research-areas/epigenetics">epigenetic targets</a> and targeting the immune system in cancer with small molecules. Check out the full range of titles.</p> <p><em>PROTAC<sup>®</sup> is a registered trademark of Arvinas Operations, Inc., and is used under license.</em></p></div> <a href="/resources" class="btn btn-primary" type="link"> Find More Resources </a> </div> </div> </div> </div> </div> </div> </div> <div></div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-3-media-to-text paragraph--view-mode--default mb-4 p-3"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--25-75"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/dw-ges-page-img-4-v2.png" alt="TcBuster graphic" loading="lazy" > </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_header_2_global"> <div><h4>Non-Viral Gene Transfer</h4></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p> </p><p>Realize the potential of gene engineering by partnering with our experts. 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