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id="toc-Preparations-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Veterinary_use" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Veterinary_use"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Veterinary use</span> </div> </a> <button aria-controls="toc-Veterinary_use-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Veterinary use subsection</span> </button> <ul id="toc-Veterinary_use-sublist" class="vector-toc-list"> <li id="toc-Bacterial_resistance" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Bacterial_resistance"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.1</span> <span>Bacterial resistance</span> </div> </a> <ul id="toc-Bacterial_resistance-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Amoxicillin/clavulanic acid</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 27 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-27" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">27 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A3%D9%85%D9%88%D9%83%D8%B3%D9%8A%D8%B3%D9%8A%D9%84%D9%8A%D9%86/%D8%AD%D9%85%D8%B6_%D8%A7%D9%84%D9%83%D9%84%D8%A7%D9%81%D9%88%D9%84%D8%A7%D9%86%D9%8A%D9%83" title="أموكسيسيلين/حمض الكلافولانيك – Arabic" lang="ar" hreflang="ar" data-title="أموكسيسيلين/حمض الكلافولانيك" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%DA%A9%D9%88%D8%A2%D9%85%D9%88%DA%A9%D8%B3%DB%8C%E2%80%8C%DA%A9%D9%84%D8%A7%D9%88" title="کوآموکسی‌کلاو – South Azerbaijani" lang="azb" hreflang="azb" data-title="کوآموکسی‌کلاو" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%90%D0%BC%D0%BE%D0%BA%D1%81%D0%B8%D1%86%D0%B8%D0%BB%D0%B8%D0%BD/%D0%9A%D0%BB%D0%B0%D0%B2%D1%83%D0%BB%D0%B0%D0%BD%D0%BE%D0%B2%D0%B0_%D0%BA%D0%B8%D1%81%D0%B5%D0%BB%D0%B8%D0%BD%D0%B0" title="Амоксицилин/Клавуланова киселина – Bulgarian" lang="bg" hreflang="bg" data-title="Амоксицилин/Клавуланова киселина" data-language-autonym="Български" data-language-local-name="Bulgarian" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Amoxicil%C2%B7lina/%C3%A0cid_clavul%C3%A0nic" title="Amoxicil·lina/àcid clavulànic – Catalan" lang="ca" hreflang="ca" data-title="Amoxicil·lina/àcid clavulànic" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%91%CE%BC%CE%BF%CE%BE%CF%85%CE%BA%CE%B9%CE%BB%CE%BB%CE%AF%CE%BD%CE%B7/%CE%BA%CE%BB%CE%B1%CE%B2%CE%BF%CF%85%CE%BB%CE%B1%CE%BD%CE%B9%CE%BA%CF%8C_%CE%BF%CE%BE%CF%8D" title="Αμοξυκιλλίνη/κλαβουλανικό οξύ – Greek" lang="el" hreflang="el" data-title="Αμοξυκιλλίνη/κλαβουλανικό οξύ" data-language-autonym="Ελληνικά" data-language-local-name="Greek" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Amoxicilina/%C3%A1cido_clavul%C3%A1nico" title="Amoxicilina/ácido clavulánico – Spanish" lang="es" hreflang="es" data-title="Amoxicilina/ácido clavulánico" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Amoxizilina/klabulaniko" title="Amoxizilina/klabulaniko – Basque" lang="eu" hreflang="eu" data-title="Amoxizilina/klabulaniko" data-language-autonym="Euskara" data-language-local-name="Basque" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%DA%A9%D9%88%D8%A2%D9%85%D9%88%DA%A9%D8%B3%DB%8C%E2%80%8C%DA%A9%D9%84%D8%A7%D9%88" title="کوآموکسی‌کلاو – Persian" lang="fa" hreflang="fa" data-title="کوآموکسی‌کلاو" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Amoxicilline/acide_clavulanique" title="Amoxicilline/acide clavulanique – French" lang="fr" hreflang="fr" data-title="Amoxicilline/acide clavulanique" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%95%84%EB%AA%A9%EC%8B%9C%EC%8B%A4%EB%A6%B0/%ED%81%B4%EB%9D%BC%EB%B6%88%EB%9E%80%EC%82%B0" title="아목시실린/클라불란산 – Korean" lang="ko" hreflang="ko" data-title="아목시실린/클라불란산" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D4%B1%D5%B4%D5%B8%D6%84%D5%BD%D5%AB%D6%81%D5%AB%D5%AC%D5%AB%D5%B6/%D5%AF%D5%AC%D5%A1%D5%BE%D5%B8%D6%82%D5%AC%D5%A1%D5%B6%D5%A1%D5%A9%D5%A9%D5%B8%D6%82" title="Ամոքսիցիլին/կլավուլանաթթու – Armenian" lang="hy" hreflang="hy" data-title="Ամոքսիցիլին/կլավուլանաթթու" data-language-autonym="Հայերեն" data-language-local-name="Armenian" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Amoksisilin-asam_klavulanat" title="Amoksisilin-asam klavulanat – Indonesian" lang="id" hreflang="id" data-title="Amoksisilin-asam klavulanat" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Amoxicillina-acido_clavulanico" title="Amoxicillina-acido clavulanico – Italian" lang="it" hreflang="it" data-title="Amoxicillina-acido clavulanico" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%90%D7%9E%D7%95%D7%A7%D7%A1%D7%99%D7%A6%D7%99%D7%9C%D7%99%D7%9F/%D7%97%D7%95%D7%9E%D7%A6%D7%94_%D7%A7%D7%9C%D7%95%D7%95%D7%9C%D7%A0%D7%99%D7%AA" title="אמוקסיצילין/חומצה קלוולנית – Hebrew" lang="he" hreflang="he" data-title="אמוקסיצילין/חומצה קלוולנית" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Synulox" title="Synulox – Dutch" lang="nl" hreflang="nl" data-title="Synulox" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%A2%E3%83%A2%E3%82%AD%E3%82%B7%E3%82%B7%E3%83%AA%E3%83%B3%E3%83%BB%E3%82%AF%E3%83%A9%E3%83%96%E3%83%A9%E3%83%B3%E9%85%B8" title="アモキシシリン・クラブラン酸 – Japanese" lang="ja" hreflang="ja" data-title="アモキシシリン・クラブラン酸" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%86%E0%AC%AE%E0%AD%8B%E0%AC%95%E0%AD%8D%E0%AC%B8%E0%AC%BF%E0%AC%B8%E0%AC%BF%E0%AC%B2%E0%AC%BF%E0%AC%A8/%E0%AC%95%E0%AD%8D%E0%AC%B2%E0%AC%BE%E0%AC%AD%E0%AD%81%E0%AC%B2%E0%AC%BE%E0%AC%A8%E0%AC%BF%E0%AC%95_%E0%AC%8F%E0%AC%B8%E0%AC%BF%E0%AC%A1" title="ଆମୋକ୍ସିସିଲିନ/କ୍ଲାଭୁଲାନିକ ଏସିଡ – Odia" lang="or" hreflang="or" data-title="ଆମୋକ୍ସିସିଲିନ/କ୍ଲାଭୁଲାନିକ ଏସିଡ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Amoxicilina/%C3%A1cido_clavul%C3%A2nico" title="Amoxicilina/ácido clavulânico – Portuguese" lang="pt" hreflang="pt" data-title="Amoxicilina/ácido clavulânico" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Amoxicilin%C4%83/acid_clavulanic" title="Amoxicilină/acid clavulanic – Romanian" lang="ro" hreflang="ro" data-title="Amoxicilină/acid clavulanic" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%90%D0%BC%D0%BE%D0%BA%D1%81%D0%B8%D1%86%D0%B8%D0%BB%D0%BB%D0%B8%D0%BD_%2B_%D0%BA%D0%BB%D0%B0%D0%B2%D1%83%D0%BB%D0%B0%D0%BD%D0%BE%D0%B2%D0%B0%D1%8F_%D0%BA%D0%B8%D1%81%D0%BB%D0%BE%D1%82%D0%B0" title="Амоксициллин + клавулановая кислота – Russian" lang="ru" hreflang="ru" data-title="Амоксициллин + клавулановая кислота" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Co-amoxiclav" title="Co-amoxiclav – Simple English" lang="en-simple" hreflang="en-simple" data-title="Co-amoxiclav" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Amoksicilin/klavulanska_kiselina" title="Amoksicilin/klavulanska kiselina – Serbian" lang="sr" hreflang="sr" data-title="Amoksicilin/klavulanska kiselina" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Amoksicilin/klavulanska_kiselina" title="Amoksicilin/klavulanska kiselina – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Amoksicilin/klavulanska kiselina" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Amoksisilin/klavulanik_asit" title="Amoksisilin/klavulanik asit – Turkish" lang="tr" hreflang="tr" data-title="Amoksisilin/klavulanik asit" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%90%D0%BC%D0%BE%D0%BA%D1%81%D0%B8%D1%86%D0%B8%D0%BB%D1%96%D0%BD/%D0%BA%D0%BB%D0%B0%D0%B2%D1%83%D0%BB%D0%B0%D0%BD%D0%BE%D0%B2%D0%B0_%D0%BA%D0%B8%D1%81%D0%BB%D0%BE%D1%82%D0%B0" title="Амоксицилін/клавуланова кислота – Ukrainian" lang="uk" hreflang="uk" data-title="Амоксицилін/клавуланова кислота" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Amoxicillin/acid_clavulanic" title="Amoxicillin/acid clavulanic – Vietnamese" lang="vi" hreflang="vi" data-title="Amoxicillin/acid clavulanic" data-language-autonym="Tiếng Việt" data-language-local-name="Vietnamese" class="interlanguage-link-target"><span>Tiếng 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searchaux" style="display:none">Combination antibiotic medication</div> <p class="mw-empty-elt"> </p> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Amoxicillin/clavulanic acid">Amoxicillin/clavulanic acid</span></caption><tbody><tr><td colspan="2" class="infobox-image notheme" style="background-color: #f8f9fa;"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Amoxicillin_and_clavulanic_acid.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/42/Amoxicillin_and_clavulanic_acid.svg/220px-Amoxicillin_and_clavulanic_acid.svg.png" decoding="async" width="220" height="197" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/42/Amoxicillin_and_clavulanic_acid.svg/330px-Amoxicillin_and_clavulanic_acid.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/42/Amoxicillin_and_clavulanic_acid.svg/440px-Amoxicillin_and_clavulanic_acid.svg.png 2x" data-file-width="512" data-file-height="458" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Combination of</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Amoxicillin" title="Amoxicillin">Amoxicillin</a></th><td class="infobox-data"><a href="/wiki/Penicillin" title="Penicillin">Penicillin antibiotic</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Clavulanic_acid" title="Clavulanic acid">Clavulanic acid</a></th><td class="infobox-data"><a href="/wiki/Beta-lactamase_inhibitor" class="mw-redirect" title="Beta-lactamase inhibitor">Beta-lactamase inhibitor</a></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Augmentin, Clavulin, Amoclan, others<sup id="cite_ref-Ric2015_1-0" class="reference"><a href="#cite_note-Ric2015-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Other names</th><td class="infobox-data">Co-amoxiclav; Amox-clav</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/amoxicillin-and-clavulanate-potassium.html">Monograph</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></th><td class="infobox-data"><span title="medlineplus.gov"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a685024.html">a685024</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">License data</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"> <ul><li><small><abbr class="country-name" title="United States">US</abbr></small> <a href="/wiki/DailyMed" title="DailyMed">DailyMed</a>: <span title="dailymed.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Amoxicillin+clavulanate">Amoxicillin clavulanate</a></span></li></ul></div> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Pregnancy_category" title="Pregnancy category">Pregnancy<br />category</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> B1</li> <li class="mw-empty-elt"></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data"><a href="/wiki/Oral_administration" title="Oral administration">By mouth</a>, <a href="/wiki/Intravenous_therapy" title="Intravenous therapy">intravenous</a><sup id="cite_ref-WHO2008_2-0" class="reference"><a href="#cite_note-WHO2008-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a href="/wiki/ATC_code_J01" title="ATC code J01">J01CR02</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=J01CR02">WHO</a></span>) <a href="/wiki/ATC_code_J01" title="ATC code J01">QJ01CR02</a> (<span title="www.whocc.no/atcvet"><a rel="nofollow" class="external text" href="https://www.whocc.no/atcvet/atcvet_index/?code=QJ01CR02">WHO</a></span>)</li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> <a href="/wiki/Standard_for_the_Uniform_Scheduling_of_Medicines_and_Poisons#Schedule_4" title="Standard for the Uniform Scheduling of Medicines and Poisons">S4</a> (Prescription only)<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="Canada">CA</abbr></small>: <a href="/wiki/Prescription_drug" title="Prescription drug"> ℞-only</a><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="United Kingdom">UK</abbr>:</small> <a href="/wiki/Prescription_drug" title="Prescription drug">POM</a> (Prescription only)</li> <li><small><abbr class="country-name" title="United States">US</abbr>:</small> <a href="/wiki/Prescription_drug" title="Prescription drug">℞-only</a></li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=74469-00-4">74469-00-4</a></span></li><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=74428-36-7">74428-36-7</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/6435924">6435924</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.4940608.html">4940608</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D06485">D06485</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembl/explore/compound/ChEMBL1697738">ChEMBL1697738</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID40225477">DTXSID40225477</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q2870929#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>24</sub><span title="Hydrogen">H</span><sub>27</sub><span title="Potassium">K</span><span title="Nitrogen">N</span><sub>4</sub><span title="Oxygen">O</span><sub>10</sub><span title="Sulfur">S</span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data"><span class="nowrap"><span data-sort-value="7002602660000000000♠"></span>602.66</span> g·mol<sup>−1</sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=CC1%28C%28N2C%28S1%29C%28C2%3DO%29NC%28%3DO%29C%28C3%3DCC%3DC%28C%3DC3%29O%29N%29C%28%3DO%29O%29C.C1C2N%28C1%3DO%29C%28C%28%3DCCO%29O2%29C%28%3DO%29%5BO-%5D.%5BK%2B%5D">Interactive image</a></span></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C.C1C2N(C1=O)C(C(=CCO)O2)C(=O)[O-].[K+]</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=DWHGNUUWCJZQHO-ZVDZYBSKSA-M</div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:1S/C16H19N3O5S.C8H9NO5.K/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7;10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24);1,6-7,10H,2-3H2,(H,12,13);/q;;+1/p-1/b;4-1-;/t9-,10-,11+,14-;6-,7-;/m11./s1</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-below"><style data-mw-deduplicate="TemplateStyles:r886047488">.mw-parser-output .nobold{font-weight:normal}</style><span class="nobold"> <sup><span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span><span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup> <a href="/wiki/Wikipedia:WikiProject_Chemicals/Chembox_validation" title="Wikipedia:WikiProject Chemicals/Chembox validation">(what is this?)</a></span><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r886047488"><span class="nobold">  <span class="reflink plainlinks nourlexpansion"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=Special:ComparePages&rev1=477162713&page2=Amoxicillin%2Fclavulanic+acid">(verify)</a></span></span></td></tr></tbody></table> <p><b>Amoxicillin/clavulanic acid</b>, also known as <b>co-amoxiclav</b> or <b>amox-clav</b>, sold under the brand name <b>Augmentin</b>, among others, is an <a href="/wiki/Antibiotic" title="Antibiotic">antibiotic</a> medication used for the treatment of a number of <a href="/wiki/Bacterial_infections" class="mw-redirect" title="Bacterial infections">bacterial infections</a>.<sup id="cite_ref-AHFS2016_5-0" class="reference"><a href="#cite_note-AHFS2016-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> It is a combination consisting of <a href="/wiki/Amoxicillin" title="Amoxicillin">amoxicillin</a>, a <a href="/wiki/%CE%92-lactam_antibiotic" class="mw-redirect" title="Β-lactam antibiotic">β-lactam antibiotic</a>, and <a href="/wiki/Potassium_clavulanate" class="mw-redirect" title="Potassium clavulanate">potassium clavulanate</a>, a <a href="/wiki/%CE%92-lactamase_inhibitor" class="mw-redirect" title="Β-lactamase inhibitor">β-lactamase inhibitor</a>.<sup id="cite_ref-AHFS2016_5-1" class="reference"><a href="#cite_note-AHFS2016-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> It is specifically used for <a href="/wiki/Otitis_media" title="Otitis media">otitis media</a>, <a href="/wiki/Streptococcal_pharyngitis" title="Streptococcal pharyngitis">streptococcal pharyngitis</a>, <a href="/wiki/Pneumonia" title="Pneumonia">pneumonia</a>, <a href="/wiki/Cellulitis" title="Cellulitis">cellulitis</a>, <a href="/wiki/Urinary_tract_infections" class="mw-redirect" title="Urinary tract infections">urinary tract infections</a>, and <a href="/wiki/Animal_bites" class="mw-redirect" title="Animal bites">animal bites</a>.<sup id="cite_ref-AHFS2016_5-2" class="reference"><a href="#cite_note-AHFS2016-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> It is taken <a href="/wiki/Oral_administration" title="Oral administration">by mouth</a> or by <a href="/wiki/Intravenous" class="mw-redirect" title="Intravenous">injection into a vein</a>.<sup id="cite_ref-WHO2008_2-1" class="reference"><a href="#cite_note-WHO2008-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p><p>Common <a href="/wiki/Side_effects" class="mw-redirect" title="Side effects">side effects</a> include <a href="/wiki/Diarrhea" title="Diarrhea">diarrhea</a>, vomiting, and <a href="/wiki/Allergic_reactions" class="mw-redirect" title="Allergic reactions">allergic reactions</a>.<sup id="cite_ref-AHFS2016_5-3" class="reference"><a href="#cite_note-AHFS2016-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> It also increases the risk of <a href="/wiki/Candidiasis" title="Candidiasis">yeast infections</a>, headaches, and <a href="/wiki/Blood_clotting_problems" class="mw-redirect" title="Blood clotting problems">blood clotting problems</a>.<sup id="cite_ref-WHO2008_2-2" class="reference"><a href="#cite_note-WHO2008-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> It is not recommended in people with a history of a <a href="/wiki/Penicillin_allergy" class="mw-redirect" title="Penicillin allergy">penicillin allergy</a>.<sup id="cite_ref-WHO2008_2-3" class="reference"><a href="#cite_note-WHO2008-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> It is relatively safe for use during pregnancy.<sup id="cite_ref-AHFS2016_5-4" class="reference"><a href="#cite_note-AHFS2016-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>Amoxicillin/clavulanic acid was approved for medical use in the United States in 1984.<sup id="cite_ref-AHFS2016_5-5" class="reference"><a href="#cite_note-AHFS2016-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> It is on the <a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">World Health Organization's List of Essential Medicines</a>.<sup id="cite_ref-WHO21st_7-0" class="reference"><a href="#cite_note-WHO21st-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-WHO22nd_8-0" class="reference"><a href="#cite_note-WHO22nd-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> The World Health Organization classifies amoxicillin/clavulanic-acid as critically important for human medicine.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> It is available as a generic medication.<sup id="cite_ref-AHFS2016_5-6" class="reference"><a href="#cite_note-AHFS2016-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> In 2022, it was the 96th most commonly prescribed medication in the United States, with more than 6<span class="nowrap"> </span>million prescriptions.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Medical_uses">Medical uses</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amoxicillin/clavulanic_acid&action=edit&section=1" title="Edit section: Medical uses"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Amoxicillin/clavulanic acid is widely used to treat or prevent many infections caused by susceptible bacteria, such as: </p> <ul><li><a href="/wiki/Urinary_tract_infection" title="Urinary tract infection">Urinary tract infections</a></li> <li><a href="/wiki/Respiratory_tract_infection" title="Respiratory tract infection">Respiratory tract infections</a></li> <li><a href="/wiki/Skin_infection" title="Skin infection">Skin</a> and soft tissue infections</li> <li><a href="/wiki/Sinus_infections" class="mw-redirect" title="Sinus infections">Sinus infections</a></li> <li><a href="/wiki/Tonsillitis" title="Tonsillitis">Tonsillitis</a></li> <li>Cat scratches</li> <li>Infections caused by the <a href="/wiki/Oral_microbiology" title="Oral microbiology">bacterial flora of the mouth</a>, such as: <ul><li><a href="/wiki/Dental_infection" class="mw-redirect" title="Dental infection">Dental infections</a></li> <li>Infected <a href="/wiki/Animal_bite" title="Animal bite">animal bites</a></li> <li>Infected human bites (including uncomplicated <a href="/wiki/Reverse_bite_injury" class="mw-redirect" title="Reverse bite injury">"clenched-fist" or "reverse-bite" injuries</a>)<sup id="cite_ref-BNF_12-0" class="reference"><a href="#cite_note-BNF-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Kucers_13-0" class="reference"><a href="#cite_note-Kucers-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup></li></ul></li> <li>Treatment-resistant <a href="/wiki/Tuberculosis" title="Tuberculosis">tuberculosis</a> (see below)</li></ul> <div class="mw-heading mw-heading3"><h3 id="Urinary_tract_infections">Urinary tract infections</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amoxicillin/clavulanic_acid&action=edit&section=2" title="Edit section: Urinary tract infections"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Amoxicillin/clavulanic acid is a <a href="/wiki/Second-line_therapy" class="mw-redirect" title="Second-line therapy">second-line therapy</a> in the treatment of uncomplicated <a href="/wiki/Urinary_tract_infection" title="Urinary tract infection">urinary tract infections</a> (UTIs).<sup id="cite_ref-GrigoryanTrautnerGupta2014_14-0" class="reference"><a href="#cite_note-GrigoryanTrautnerGupta2014-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-BaderLoebLeto2020_15-0" class="reference"><a href="#cite_note-BaderLoebLeto2020-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> It is active against UTIs caused by <i><a href="/wiki/Staphylococcus_saprophyticus" title="Staphylococcus saprophyticus">Staphylococcus saprophyticus</a></i>, <i><a href="/wiki/Enterococci" class="mw-redirect" title="Enterococci">Enterococci</a></i> (e.g., <i><a href="/wiki/Enterococcus_faecalis" title="Enterococcus faecalis">Enterococcus faecalis</a></i>), <i><a href="/wiki/Escherichia_coli" title="Escherichia coli">Escherichia coli</a></i>, <i><a href="/wiki/Klebsiella_pneumoniae" title="Klebsiella pneumoniae">Klebsiella pneumoniae</a></i>, and <i><a href="/wiki/Proteus_mirabilis" title="Proteus mirabilis">Proteus mirabilis</a></i>.<sup id="cite_ref-BaderLoebLeto2020_15-1" class="reference"><a href="#cite_note-BaderLoebLeto2020-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> It is a definitive treatment against susceptible <a href="/wiki/Beta-lactamase#Extended-spectrum_beta-lactamase_(ESBL)" title="Beta-lactamase">extended-spectrum β-lactamase</a> (ESBL)-producing <a href="/wiki/Gram-negative_bacteria" title="Gram-negative bacteria">Gram-negative bacteria</a>.<sup id="cite_ref-BaderLoebLeto2020_15-2" class="reference"><a href="#cite_note-BaderLoebLeto2020-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> The drug is not effective against <i><a href="/wiki/Pseudomonas_aeruginosa" title="Pseudomonas aeruginosa">Pseudomonas aeruginosa</a></i>, <i><a href="/wiki/Morganella_morganii" title="Morganella morganii">Morganella morganii</a></i>, or <i><a href="/wiki/Providencia_stuartii" title="Providencia stuartii">Providencia stuartii</a></i>, nor against <a href="/wiki/AmpC_%CE%B2-lactamase" class="mw-redirect" title="AmpC β-lactamase">AmpC β-lactamase</a>- and ESBL-producing Gram-negative bacteria or <a href="/wiki/Carbapenem-resistant_Enterobacteriaceae" class="mw-redirect" title="Carbapenem-resistant Enterobacteriaceae">carbapenem-resistant Enterobacteriaceae</a> (CRE).<sup id="cite_ref-BaderLoebLeto2020_15-3" class="reference"><a href="#cite_note-BaderLoebLeto2020-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> It is not recommended in the <a href="/wiki/Empiric_therapy" title="Empiric therapy">empiric treatment</a> of acute <a href="/wiki/Pyelonephritis" title="Pyelonephritis">pyelonephritis</a> or <a href="/wiki/Hospital-acquired_infection" title="Hospital-acquired infection">hospital-acquired</a> UTIs.<sup id="cite_ref-BaderLoebLeto2020_15-4" class="reference"><a href="#cite_note-BaderLoebLeto2020-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p><p>As determined by a 2014 <a href="/wiki/Literature_review" title="Literature review">literature review</a> of antibiotics for UTIs, respective early clinical cure and early bacterial cure rates were 91% and 91% for <a href="/wiki/Trimethoprim/sulfamethoxazole" title="Trimethoprim/sulfamethoxazole">trimethoprim/sulfamethoxazole</a>, 92% and 87% for <a href="/wiki/Nitrofurantoin" title="Nitrofurantoin">nitrofurantoin</a>, 91% and 83% for <a href="/wiki/Fosfomycin" title="Fosfomycin">fosfomycin</a>, 90% and 91% for <a href="/wiki/Fluoroquinolone" class="mw-redirect" title="Fluoroquinolone">fluoroquinolones</a> (<a href="/wiki/Ciprofloxacin" title="Ciprofloxacin">ciprofloxacin</a> and <a href="/wiki/Norfloxacin" title="Norfloxacin">norfloxacin</a>), and 86% and 81% for <a href="/wiki/%CE%92-lactam" class="mw-redirect" title="Β-lactam">β-lactams</a> (amoxicillin/clavulanic acid and <a href="/wiki/Cefpodoxime" title="Cefpodoxime">cefpodoxime</a>).<sup id="cite_ref-GrigoryanTrautnerGupta2014_14-1" class="reference"><a href="#cite_note-GrigoryanTrautnerGupta2014-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> In a large high-quality <a href="/wiki/Randomized_controlled_trial" title="Randomized controlled trial">randomized controlled trial</a> of amoxicillin/clavulanic acid for UTI in 370<span class="nowrap"> </span>women, early and late clinical cure rates were 79% and 58%, respectively.<sup id="cite_ref-GrigoryanTrautnerGupta2014_14-2" class="reference"><a href="#cite_note-GrigoryanTrautnerGupta2014-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> Amoxicillin/clavulanic acid reaches a relatively low <a href="/wiki/Urine" title="Urine">urine</a> concentration, which might be involved in its lower effectiveness than other antibiotics.<sup id="cite_ref-BaderLoebLeto2020_15-5" class="reference"><a href="#cite_note-BaderLoebLeto2020-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p><p>Amoxicillin/clavulanic acid is less effective in the treatment of UTI than <a href="/wiki/Therapy#Lines_of_therapy" title="Therapy">first-line therapies</a> used to treat UTIs.<sup id="cite_ref-GrigoryanTrautnerGupta2014_14-3" class="reference"><a href="#cite_note-GrigoryanTrautnerGupta2014-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-KnottnerusGrigoryanGeerlings2012_16-0" class="reference"><a href="#cite_note-KnottnerusGrigoryanGeerlings2012-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> A 2012 <a href="/wiki/Network_meta-analysis" class="mw-redirect" title="Network meta-analysis">network meta-analysis</a> of antibiotics for uncomplicated UTIs found that it was less effective than all other assessed agents, including trimethoprim/sulfamethoxazole, nitrofurantoin, fosfomycin, fluoroquinolones (ciprofloxacin, norfloxacin, and <a href="/wiki/Gatifloxacin" title="Gatifloxacin">gatifloxacin</a>), and <a href="/wiki/Pivmecillinam" title="Pivmecillinam">pivmecillinam</a>.<sup id="cite_ref-KnottnerusGrigoryanGeerlings2012_16-1" class="reference"><a href="#cite_note-KnottnerusGrigoryanGeerlings2012-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> However, selection of an empirical antibiotic should be based on local or regional susceptibility data.<sup id="cite_ref-BaderLoebLeto2020_15-6" class="reference"><a href="#cite_note-BaderLoebLeto2020-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Additionally, selection of the most appropriate and narrowest effective antibiotic is recommended to help limit increased <a href="/wiki/Antibiotic_resistance" class="mw-redirect" title="Antibiotic resistance">antibiotic resistance</a> to <a href="/wiki/Broad-spectrum_antibiotic" title="Broad-spectrum antibiotic">broad-spectrum antibiotics</a>.<sup id="cite_ref-BaderLoebLeto2020_15-7" class="reference"><a href="#cite_note-BaderLoebLeto2020-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p><p>Combining amoxicillin/clavulanic acid with <a href="/wiki/Aztreonam" title="Aztreonam">aztreonam</a> can further enhance its activity against certain resistant UTI-causing bacteria.<sup id="cite_ref-BaderLoebLeto2020_15-8" class="reference"><a href="#cite_note-BaderLoebLeto2020-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Tuberculosis">Tuberculosis</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amoxicillin/clavulanic_acid&action=edit&section=3" title="Edit section: Tuberculosis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>It is also used for <a href="/wiki/Tuberculosis" title="Tuberculosis">tuberculosis</a> that is resistant to other treatments.<sup id="cite_ref-AHFS2016_5-7" class="reference"><a href="#cite_note-AHFS2016-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> The World Health Organization recommends giving amoxicillin-clavulanate along with <a href="/wiki/Meropenem" title="Meropenem">meropenem</a> as one of the therapeutic options in <a href="/wiki/Drug-resistant_tuberculosis" class="mw-redirect" title="Drug-resistant tuberculosis">drug-resistant tuberculosis</a>.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> However, across the spectrum of dosage of amoxicillin-clavulanate combination, the dose of clavulanate is constant at 125 mg, whereas the dose of amoxicillin varies at 250 mg, 500 mg and 875 mg. Thus the use of low-dose amoxicillin-clavulanate in combination with meropenem may be used in part of a treatment regimen for drug-resistant TB and this has been demonstrated in a clinical setting also. Its efficacy is attributed not to the amoxicillin component, but to the protective action of clavulanic acid over meropenem against <a href="/wiki/Beta-lactamase" title="Beta-lactamase">beta-lactamase</a> produced by the <a href="/wiki/Mycobacteria" class="mw-redirect" title="Mycobacteria">mycobacteria</a>. Therefore, the minimum dosage of amoxicillin (250 mg) is recommended.<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Adverse_effects">Adverse effects</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amoxicillin/clavulanic_acid&action=edit&section=4" title="Edit section: Adverse effects"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Possible side effects include <a href="/wiki/Diarrhea" title="Diarrhea">diarrhea</a>, vomiting, <a href="/wiki/Nausea" title="Nausea">nausea</a>, <a href="/wiki/Candidiasis" title="Candidiasis">thrush</a>, and skin <a href="/wiki/Rash" title="Rash">rash</a>. These do not usually require medical attention. As with all antimicrobial agents, <a href="/wiki/Antibiotic-associated_diarrhea" title="Antibiotic-associated diarrhea">antibiotic-associated diarrhea</a> due to <i><a href="/wiki/Clostridioides_difficile_(bacteria)" class="mw-redirect" title="Clostridioides difficile (bacteria)">Clostridioides difficile</a></i> infection—sometimes leading to <a href="/wiki/Pseudomembranous_colitis" class="mw-redirect" title="Pseudomembranous colitis">pseudomembranous colitis</a>—may occur during or after treatment with amoxicillin/clavulanic acid.<sup id="cite_ref-Kucers_13-1" class="reference"><a href="#cite_note-Kucers-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p><p>Rarely, <a href="/wiki/Cholestasis" title="Cholestasis">cholestatic</a> jaundice (also referred to as cholestatic hepatitis, a form of <a href="/wiki/Liver_toxicity" class="mw-redirect" title="Liver toxicity">liver toxicity</a>) has been associated with amoxicillin/clavulanic acid. The reaction may occur up to several weeks after treatment has stopped and usually takes weeks to resolve. It is more frequent in men, older people, and those who have taken long courses of treatment; the estimated overall incidence is one in 100,000 exposures.<sup id="cite_ref-Kucers_13-2" class="reference"><a href="#cite_note-Kucers-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> In the United Kingdom, co-amoxiclav carries a warning from the <a href="/wiki/Committee_on_Safety_of_Medicines" title="Committee on Safety of Medicines">Committee on Safety of Medicines</a> to this effect.<sup id="cite_ref-BNF_12-1" class="reference"><a href="#cite_note-BNF-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p><p>As all <a href="/wiki/Aminopenicillin" title="Aminopenicillin">aminopenicillins</a>, amoxicillin has been associated with <a href="/wiki/Stevens%E2%80%93Johnson_syndrome" title="Stevens–Johnson syndrome">Stevens–Johnson syndrome</a> / <a href="/wiki/Toxic_epidermal_necrolysis" title="Toxic epidermal necrolysis">toxic epidermal necrolysis</a>, although these reactions are very rare.<sup id="cite_ref-Kucers_13-3" class="reference"><a href="#cite_note-Kucers-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Pharmacology">Pharmacology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amoxicillin/clavulanic_acid&action=edit&section=5" title="Edit section: Pharmacology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Amoxicillin" title="Amoxicillin">Amoxicillin</a> is an <a href="/wiki/Antibiotic" title="Antibiotic">antibiotic</a> while <a href="/wiki/Clavulanic_acid" title="Clavulanic acid">clavulanic acid</a> is a non-antibiotic <a href="/wiki/%CE%92-lactamase_inhibitor" class="mw-redirect" title="Β-lactamase inhibitor">β-lactamase inhibitor</a> which prevents <a href="/wiki/Drug_metabolism" title="Drug metabolism">metabolism</a> of amoxicillin by certain <a href="/wiki/Bacteria" title="Bacteria">bacteria</a>. </p><p>In addition to its β-lactamase inhibition, clavulanic acid shows <a href="/wiki/Central_nervous_system" title="Central nervous system">central nervous system</a> actions and effects and <a href="/wiki/Clavulanic_acid#Neuromodulation" title="Clavulanic acid">has been studied</a> in the potential treatment of various <a href="/wiki/Psychiatric_disorder" class="mw-redirect" title="Psychiatric disorder">psychiatric</a> and <a href="/wiki/Neurological_disorder" title="Neurological disorder">neurological disorders</a>.<sup id="cite_ref-Balcazar-OchoaVentura-MartínezÁngeles-López2024_20-0" class="reference"><a href="#cite_note-Balcazar-OchoaVentura-MartínezÁngeles-López2024-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Ochoa-AguilarVentura-MartinezSotomayor-Sobrino2016_21-0" class="reference"><a href="#cite_note-Ochoa-AguilarVentura-MartinezSotomayor-Sobrino2016-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-MilenkovicCampbellRoussel2018_22-0" class="reference"><a href="#cite_note-MilenkovicCampbellRoussel2018-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ConnollyThase2012_23-0" class="reference"><a href="#cite_note-ConnollyThase2012-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AdisInsight-Clavulanic-Acid_24-0" class="reference"><a href="#cite_note-AdisInsight-Clavulanic-Acid-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="History">History</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amoxicillin/clavulanic_acid&action=edit&section=6" title="Edit section: History"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>British scientists working at <a href="/wiki/Beecham_(pharmaceutical_company)" class="mw-redirect" title="Beecham (pharmaceutical company)">Beecham</a> (now part of <a href="/wiki/GlaxoSmithKline" class="mw-redirect" title="GlaxoSmithKline">GlaxoSmithKline</a>), filed for patent protection for the drug combination in 1977, which was granted in 1982.<sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> </p><p>It was sold under the brand name Augmentin.<sup id="cite_ref-BNF_12-2" class="reference"><a href="#cite_note-BNF-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Bryan2011_26-0" class="reference"><a href="#cite_note-Bryan2011-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Preparations">Preparations</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amoxicillin/clavulanic_acid&action=edit&section=7" title="Edit section: Preparations"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Amoxicillin/clavulanic acid is the <a href="/wiki/International_Nonproprietary_Name" class="mw-redirect" title="International Nonproprietary Name">International Nonproprietary Name</a> (INN) and co-amoxiclav is the <a href="/wiki/British_Approved_Name" title="British Approved Name">British Approved Name</a> (BAN).<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (April 2021)">citation needed</span></a></i>]</sup> </p><p>Many branded products indicate their strengths as the quantity of amoxicillin. Augmentin 250, for example, contains 250 mg of amoxicillin and 125 mg of <a href="/wiki/Clavulanic_acid" title="Clavulanic acid">clavulanic acid</a>.<sup id="cite_ref-BNF_12-3" class="reference"><a href="#cite_note-BNF-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-GSK_27-0" class="reference"><a href="#cite_note-GSK-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> </p><p>An intravenous preparation has been available in the UK since 1985,<sup id="cite_ref-pmid3190988_28-0" class="reference"><a href="#cite_note-pmid3190988-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> but no <a href="/wiki/Parenteral" class="mw-redirect" title="Parenteral">parenteral</a> preparation is available in the US;<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (April 2021)">citation needed</span></a></i>]</sup> the nearest equivalent is <a href="/wiki/Ampicillin/sulbactam" title="Ampicillin/sulbactam">ampicillin/sulbactam</a>.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (April 2021)">citation needed</span></a></i>]</sup> </p><p><a href="/wiki/Suspension_(chemistry)" title="Suspension (chemistry)">Suspensions</a> of amoxicillin/clavulanic acid are available for use in children. They must be refrigerated to maintain effectiveness.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (April 2021)">citation needed</span></a></i>]</sup> </p> <div class="mw-heading mw-heading2"><h2 id="Veterinary_use">Veterinary use</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amoxicillin/clavulanic_acid&action=edit&section=8" title="Edit section: Veterinary use"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Amoxicillin/clavulanic acid is used in numerous animals for a variety of conditions: </p> <ul><li>Dogs: Skin and soft tissue infections such as wounds, abscesses, cellulitis, superficial/juvenile and deep pyoderma due to susceptible strains of the following organisms: β-lactamase-producing Staphylococcus aureus, non-β-lactamase-producing <i>Staphylococcus aureus</i>, <i>Staphylococcus</i> spp., <i>Streptococcus</i> spp., and <i>E. coli</i>; and periodontal infections due to susceptible strains of both aerobic and anaerobic bacteria.<sup id="cite_ref-FDA_approvals_29-0" class="reference"><a href="#cite_note-FDA_approvals-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup></li></ul> <ul><li>Cats: Skin and soft tissue infections such as wounds, abscesses, and cellulitis/dermatitis due to susceptible strains of the following organisms: β-lactamase-producing <i>Staphylococcus aureus</i>, non-β-lactamase-producing <i>Staphylococcus aureus</i>, <i>Staphylococcus</i> spp., <i>Streptococcus</i> spp., <i>E. coli</i>, and <i>Pasteurella</i> spp; urinary tract infections (cystitis) due to susceptible strains of <i>E. coli.</i><sup id="cite_ref-FDA_approvals_29-1" class="reference"><a href="#cite_note-FDA_approvals-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup></li></ul> <div class="mw-heading mw-heading3"><h3 id="Bacterial_resistance">Bacterial resistance</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amoxicillin/clavulanic_acid&action=edit&section=9" title="Edit section: Bacterial resistance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Bacterial <a href="/wiki/Antibiotic_resistance" class="mw-redirect" title="Antibiotic resistance">antibiotic resistance</a> is a growing problem in <a href="/wiki/Veterinary_medicine" title="Veterinary medicine">veterinary medicine</a>. Amoxicillin/clavulanic acid is reported to be effective against clinical <i><a href="/wiki/Klebsiella" title="Klebsiella">Klebsiella</a></i> infections, but is not efficacious against <i><a href="/wiki/Pseudomonas" title="Pseudomonas">Pseudomonas</a></i> infections.<sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amoxicillin/clavulanic_acid&action=edit&section=10" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-Ric2015-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-Ric2015_1-0">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFHamilton2015" class="citation book cs1">Hamilton R (2015). <i>Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition</i>. Jones & Bartlett Learning. p. 97. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9781284057560" title="Special:BookSources/9781284057560"><bdi>9781284057560</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Tarascon+Pocket+Pharmacopoeia+2015+Deluxe+Lab-Coat+Edition&rft.pages=97&rft.pub=Jones+%26+Bartlett+Learning&rft.date=2015&rft.isbn=9781284057560&rft.aulast=Hamilton&rft.aufirst=R&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmoxicillin%2Fclavulanic+acid" class="Z3988"></span></span> </li> <li id="cite_note-WHO2008-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-WHO2008_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-WHO2008_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-WHO2008_2-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-WHO2008_2-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWorld_Health_Organization2009" class="citation book cs1"><a href="/wiki/World_Health_Organization" title="World Health Organization">World Health Organization</a> (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). <i>WHO Model Formulary 2008</i>. 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License: CC BY-NC-SA 3.0 IGO.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=World+Health+Organization+model+list+of+essential+medicines%3A+21st+list+2019&rft.place=Geneva&rft.pub=World+Health+Organization&rft.date=2019&rft_id=info%3Ahdl%2F10665%2F325771&rft.au=World+Health+Organization&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmoxicillin%2Fclavulanic+acid" class="Z3988"></span></span> </li> <li id="cite_note-WHO22nd-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-WHO22nd_8-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWorld_Health_Organization2021" class="citation book cs1"><a href="/wiki/World_Health_Organization" title="World Health Organization">World Health Organization</a> (2021). <i>World Health Organization model list of essential medicines: 22nd list (2021)</i>. 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which is in the <a href="/wiki/Public_domain" title="Public domain">public domain</a>.</span> </li> <li id="cite_note-30"><span class="mw-cite-backlink"><b><a href="#cite_ref-30">^</a></b></span> <span class="reference-text">Federation of Veterinarians in Europe Position Paper: "Antibiotic Resistance & Prudent Use of Antibiotics in Veterinary Medicine"</span> </li> </ol></div></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol 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scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Beta-lactam_antibiotics" class="mw-redirect" title="Beta-lactam antibiotics">β-lactams</a><br /><small><span class="nobold">(inhibit synthesis<br />of peptidoglycan<br />layer of bacterial<br />cell wall by binding<br />to and inhibiting<br /><a href="/wiki/Penicillin-binding_proteins" title="Penicillin-binding proteins">PBPs</a>, a group of<br /><a href="/wiki/DD-Transpeptidase" title="DD-Transpeptidase"><small>D</small>-alanyl-<small>D</small>-alanine<br />transpeptidases</a>)</span></small></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Penicillin" title="Penicillin">Penicillins</a> (<a href="/wiki/Penam" title="Penam">Penams</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_%CE%B2-lactam_antibiotics#Narrow-spectrum" title="List of β-lactam antibiotics">Narrow<br />spectrum</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_%CE%B2-lactam_antibiotics#Narrow-spectrum" title="List of β-lactam antibiotics">β-lactamase sensitive</a><br />(1st generation)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Benzylpenicillin" title="Benzylpenicillin">Benzylpenicillin (G)</a><sup>#</sup></li> <li><a href="/wiki/Benzathine_benzylpenicillin" title="Benzathine benzylpenicillin">Benzathine benzylpenicillin</a><sup>#</sup></li> <li><a href="/wiki/Procaine_benzylpenicillin" title="Procaine benzylpenicillin">Procaine benzylpenicillin</a><sup>#</sup></li> <li><a href="/wiki/Phenoxymethylpenicillin" title="Phenoxymethylpenicillin">Phenoxymethylpenicillin (V)</a><sup>#</sup></li> <li><a href="/wiki/Propicillin" title="Propicillin">Propicillin</a><sup>‡</sup></li> <li><a href="/wiki/Pheneticillin" title="Pheneticillin">Pheneticillin</a><sup>‡</sup></li> <li><a href="/wiki/Azidocillin" title="Azidocillin">Azidocillin</a><sup>‡</sup></li> <li><a href="/wiki/Clometocillin" title="Clometocillin">Clometocillin</a><sup>‡</sup></li> <li><a href="/wiki/Penamecillin" title="Penamecillin">Penamecillin</a><sup>‡</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_%CE%B2-lactam_antibiotics#β-lactamase-resistant" title="List of β-lactam antibiotics">β-lactamase resistant</a><br />(2nd generation)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cloxacillin" title="Cloxacillin">Cloxacillin</a><sup>#</sup> (<a href="/wiki/Dicloxacillin" title="Dicloxacillin">Dicloxacillin</a></li> <li><a href="/wiki/Flucloxacillin" title="Flucloxacillin">Flucloxacillin</a>)</li> <li><a href="/wiki/Oxacillin" title="Oxacillin">Oxacillin</a></li> <li><a href="/wiki/Nafcillin" title="Nafcillin">Nafcillin</a></li> <li><a href="/wiki/Methicillin" title="Methicillin">Methicillin</a><sup>‡</sup></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Extended-spectrum_penicillin" title="Extended-spectrum penicillin">Extended<br />spectrum</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Aminopenicillin" title="Aminopenicillin">Aminopenicillins</a> (3rd generation)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Amoxicillin" title="Amoxicillin">Amoxicillin</a><sup>#</sup></li> <li><a href="/wiki/Ampicillin" title="Ampicillin">Ampicillin</a><sup>#</sup> (<a href="/wiki/Pivampicillin" title="Pivampicillin">Pivampicillin</a></li> <li><a href="/wiki/Hetacillin" title="Hetacillin">Hetacillin</a><sup>‡</sup></li> <li><a href="/wiki/Bacampicillin" title="Bacampicillin">Bacampicillin</a><sup>‡</sup></li> <li><a href="/wiki/Lenampicillin" title="Lenampicillin">Lenampicillin</a></li> <li><a href="/wiki/Metampicillin" title="Metampicillin">Metampicillin</a><sup>‡</sup></li> <li><a href="/wiki/Talampicillin" title="Talampicillin">Talampicillin</a><sup>‡</sup>)</li> <li><a href="/wiki/Epicillin" title="Epicillin">Epicillin</a><sup>‡</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Carboxypenicillin" title="Carboxypenicillin">Carboxypenicillins</a> (4th generation)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ticarcillin" title="Ticarcillin">Ticarcillin</a></li> <li><a href="/wiki/Carbenicillin" title="Carbenicillin">Carbenicillin</a><sup>‡</sup> / <a href="/wiki/Carindacillin" title="Carindacillin">Carindacillin</a><sup>‡</sup></li> <li><a href="/wiki/Temocillin" title="Temocillin">Temocillin</a><sup>‡</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ureidopenicillin" title="Ureidopenicillin">Ureidopenicillins</a> (4th generation)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Piperacillin" title="Piperacillin">Piperacillin</a></li> <li><a href="/wiki/Azlocillin" title="Azlocillin">Azlocillin</a><sup>‡</sup></li> <li><a href="/wiki/Mezlocillin" title="Mezlocillin">Mezlocillin</a><sup>‡</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mecillinam" title="Mecillinam">Mecillinam</a> (<a href="/wiki/Pivmecillinam" title="Pivmecillinam">Pivmecillinam</a>)</li> <li><a href="/wiki/Sulbenicillin" title="Sulbenicillin">Sulbenicillin</a><sup>‡</sup></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Carbapenem" title="Carbapenem">Carbapenems</a> / <a href="/wiki/Penem" title="Penem">Penems</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Carbapenems (<a href="/wiki/Ertapenem" title="Ertapenem">Ertapenem</a></li> <li><a href="/wiki/Antipseudomonal" class="mw-redirect" title="Antipseudomonal">Antipseudomonal</a> (<a href="/wiki/Doripenem" title="Doripenem">Doripenem</a></li> <li><a href="/wiki/Imipenem" title="Imipenem">Imipenem</a></li> <li><a href="/wiki/Meropenem" title="Meropenem">Meropenem</a>)</li> <li><a href="/wiki/Biapenem" title="Biapenem">Biapenem</a><sup>‡</sup></li> <li><a href="/wiki/Panipenem" title="Panipenem">Panipenem</a>)</li> <li>Penems (<a href="/wiki/Faropenem" title="Faropenem">Faropenem</a></li> <li><a href="/wiki/Ritipenem" title="Ritipenem">Ritipenem</a><sup>§</sup></li> <li><a href="/wiki/Sulopenem" title="Sulopenem">Sulopenem</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cephem" title="Cephem">Cephems</a><br /><a href="/wiki/Cephalosporin" title="Cephalosporin">Cephalosporins</a><br /><a href="/wiki/Cephamycin" title="Cephamycin">Cephamycins</a><br /><a href="/wiki/Carbacephem" title="Carbacephem">Carbacephems</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cephalosporin#First_generation" title="Cephalosporin">1st generation</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cefazolin" title="Cefazolin">Cefazolin</a><sup>#</sup></li> <li><a href="/wiki/Cefalexin" title="Cefalexin">Cefalexin</a> <sup>#</sup></li> <li><a href="/wiki/Cefadroxil" title="Cefadroxil">Cefadroxil</a></li> <li><a href="/wiki/Cefapirin" title="Cefapirin">Cefapirin</a></li> <li><a href="/wiki/Cefazedone" title="Cefazedone">Cefazedone</a><sup>‡</sup></li> <li><a href="/wiki/Cefazaflur" title="Cefazaflur">Cefazaflur</a><sup>‡</sup></li> <li><a href="/wiki/Cefradine" title="Cefradine">Cefradine</a><sup>‡</sup></li> <li><a href="/wiki/Cefroxadine" title="Cefroxadine">Cefroxadine</a><sup>‡</sup></li> <li><a href="/wiki/Ceftezole" title="Ceftezole">Ceftezole</a><sup>‡</sup></li> <li><a href="/wiki/Cefaloglycin" title="Cefaloglycin">Cefaloglycin</a><sup>‡</sup></li> <li><a href="/wiki/Cefacetrile" title="Cefacetrile">Cefacetrile</a><sup>‡</sup></li> <li><a href="/wiki/Cefalonium" title="Cefalonium">Cefalonium</a><sup>‡</sup></li> <li><a href="/wiki/Cefaloridine" class="mw-redirect" title="Cefaloridine">Cefaloridine</a><sup>‡</sup></li> <li><a href="/wiki/Cefalotin" title="Cefalotin">Cefalotin</a></li> <li><a href="/wiki/Cefatrizine" title="Cefatrizine">Cefatrizine</a><sup>‡</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cephalosporin#Second_generation" title="Cephalosporin">2nd generation</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cefaclor" title="Cefaclor">Cefaclor</a></li> <li><a href="/wiki/Cefprozil" title="Cefprozil">Cefprozil</a></li> <li><a href="/wiki/Cefuroxime" title="Cefuroxime">Cefuroxime</a></li> <li><a href="/wiki/Cefuroxime_axetil" title="Cefuroxime axetil">Cefuroxime axetil</a></li> <li><a href="/wiki/Cefamandole" title="Cefamandole">Cefamandole</a><sup>‡</sup></li> <li><a href="/wiki/Cefonicid" title="Cefonicid">Cefonicid</a><sup>‡</sup></li> <li><a href="/wiki/Ceforanide" title="Ceforanide">Ceforanide</a><sup>‡</sup></li> <li><a href="/wiki/Cefuzonam" title="Cefuzonam">Cefuzonam</a><sup>‡</sup></li> <li><a href="/wiki/Cephamycin" title="Cephamycin">Cephamycin</a> (<a href="/wiki/Cefoxitin" title="Cefoxitin">Cefoxitin</a></li> <li><a href="/wiki/Cefotetan" title="Cefotetan">Cefotetan</a></li> <li><a href="/wiki/Cefminox" title="Cefminox">Cefminox</a><sup>‡</sup></li> <li><a href="/wiki/Cefbuperazone" title="Cefbuperazone">Cefbuperazone</a><sup>‡</sup></li> <li><a href="/wiki/Cefmetazole" title="Cefmetazole">Cefmetazole</a><sup>‡</sup>)</li> <li><a href="/wiki/Carbacephem" title="Carbacephem">Carbacephem</a> (<a href="/wiki/Loracarbef" title="Loracarbef">Loracarbef</a><sup>‡</sup>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cephalosporin#Third_generation" title="Cephalosporin">3rd generation</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cefixime" title="Cefixime">Cefixime</a><sup>#</sup></li> <li><a href="/wiki/Ceftriaxone" title="Ceftriaxone">Ceftriaxone</a><sup>#</sup></li> <li><a href="/wiki/Cefotaxime" title="Cefotaxime">Cefotaxime</a><sup>#</sup></li> <li>Antipseudomonal (<a href="/wiki/Ceftazidime" title="Ceftazidime">Ceftazidime</a><sup>#</sup></li> <li><a href="/wiki/Cefoperazone" title="Cefoperazone">Cefoperazone</a>)</li> <li><a href="/wiki/Cefdinir" title="Cefdinir">Cefdinir</a></li> <li><a href="/wiki/Cefcapene" title="Cefcapene">Cefcapene</a></li> <li><a href="/wiki/Cefdaloxime" title="Cefdaloxime">Cefdaloxime</a></li> <li><a href="/wiki/Ceftizoxime" title="Ceftizoxime">Ceftizoxime</a></li> <li><a href="/wiki/Cefmenoxime" title="Cefmenoxime">Cefmenoxime</a></li> <li><a href="/wiki/Cefpiramide" title="Cefpiramide">Cefpiramide</a></li> <li><a href="/wiki/Cefpodoxime" title="Cefpodoxime">Cefpodoxime</a></li> <li><a href="/wiki/Ceftibuten" title="Ceftibuten">Ceftibuten</a></li> <li><a href="/wiki/Cefditoren" title="Cefditoren">Cefditoren</a></li> <li><a href="/wiki/Cefotiam" title="Cefotiam">Cefotiam</a><sup>‡</sup></li> <li><a href="/wiki/Cefetamet" title="Cefetamet">Cefetamet</a><sup>‡</sup></li> <li><a href="/wiki/Cefodizime" title="Cefodizime">Cefodizime</a><sup>‡</sup></li> <li><a href="/wiki/Cefpimizole" title="Cefpimizole">Cefpimizole</a><sup>‡</sup></li> <li><a href="/wiki/Cefsulodin" title="Cefsulodin">Cefsulodin</a><sup>‡</sup></li> <li><a href="/wiki/Cefteram" title="Cefteram">Cefteram</a><sup>‡</sup></li> <li><a href="/wiki/Ceftiolene" title="Ceftiolene">Ceftiolene</a><sup>‡</sup></li> <li><a href="/wiki/Oxacephem" title="Oxacephem">Oxacephem</a> (<a href="/wiki/Flomoxef" title="Flomoxef">Flomoxef</a></li> <li><a href="/wiki/Latamoxef" title="Latamoxef">Latamoxef</a><sup>‡</sup>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cephalosporin#Fourth_generation" title="Cephalosporin">4th generation</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cefepime" title="Cefepime">Cefepime</a></li> <li><a href="/wiki/Cefozopran" title="Cefozopran">Cefozopran</a><sup>‡</sup></li> <li><a href="/wiki/Cefpirome" title="Cefpirome">Cefpirome</a></li> <li><a href="/wiki/Cefquinome" title="Cefquinome">Cefquinome</a><sup>‡</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cephalosporin#Fifth_generation" title="Cephalosporin">5th generation</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ceftaroline_fosamil" title="Ceftaroline fosamil">Ceftaroline fosamil</a></li> <li><a href="/wiki/Ceftolozane" class="mw-redirect" title="Ceftolozane">Ceftolozane</a></li> <li><a href="/wiki/Ceftobiprole" title="Ceftobiprole">Ceftobiprole</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Siderophore" title="Siderophore">Siderophore</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cefiderocol" title="Cefiderocol">Cefiderocol</a><sup>#</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Veterinary_medicine" title="Veterinary medicine">Veterinary</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ceftiofur" title="Ceftiofur">Ceftiofur</a></li> <li><a href="/wiki/Cefquinome" title="Cefquinome">Cefquinome</a></li> <li><a href="/wiki/Cefovecin" title="Cefovecin">Cefovecin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Monobactam" title="Monobactam">Monobactams</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aztreonam" title="Aztreonam">Aztreonam</a></li> <li><a href="/wiki/Tigemonam" title="Tigemonam">Tigemonam</a><sup>‡</sup></li> <li><a href="/wiki/Carumonam" title="Carumonam">Carumonam</a><sup>‡</sup></li> <li><a href="/wiki/Nocardicin_A" title="Nocardicin A">Nocardicin A</a><sup>‡</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/%CE%92-Lactamase_inhibitor" title="Β-Lactamase inhibitor">β-lactamase inhibitors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Penam" title="Penam">Penam</a> (<a href="/wiki/Sulbactam" title="Sulbactam">Sulbactam</a></li> <li><a href="/wiki/Tazobactam" title="Tazobactam">Tazobactam</a>)</li> <li><a href="/wiki/Clavam" title="Clavam">Clavam</a> (<a href="/wiki/Clavulanic_acid" title="Clavulanic acid">Clavulanic acid</a>)</li> <li>non-β-lactam (<a href="/wiki/Avibactam" title="Avibactam">Avibactam</a></li> <li><a href="/wiki/Durlobactam" title="Durlobactam">Durlobactam</a></li> <li><a href="/wiki/Relebactam" title="Relebactam">Relebactam</a></li> <li><a href="/wiki/Vaborbactam" title="Vaborbactam">Vaborbactam</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Combinations</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">Amoxicillin/clavulanic acid</a><sup>#</sup></li> <li><a href="/wiki/Ampicillin/flucloxacillin" title="Ampicillin/flucloxacillin">Ampicillin/flucloxacillin</a></li> <li><a href="/wiki/Ampicillin/sulbactam" title="Ampicillin/sulbactam">Ampicillin/sulbactam</a> (<a href="/wiki/Sultamicillin" title="Sultamicillin">Sultamicillin</a>)</li> <li><a href="/wiki/Aztreonam/avibactam" title="Aztreonam/avibactam">Aztreonam/avibactam</a></li> <li><a href="/wiki/Benzathine_benzylpenicillin/procaine_benzylpenicillin" title="Benzathine benzylpenicillin/procaine benzylpenicillin">Benzathine benzylpenicillin/procaine benzylpenicillin</a></li> <li><a href="/wiki/Cefepime/enmetazobactam" title="Cefepime/enmetazobactam">Cefepime/enmetazobactam</a></li> <li><a href="/wiki/Cefoperazone/sulbactam" title="Cefoperazone/sulbactam">Cefoperazone/sulbactam</a></li> <li><a href="/wiki/Ceftazidime/avibactam" title="Ceftazidime/avibactam">Ceftazidime/avibactam</a></li> <li><a href="/wiki/Ceftolozane/tazobactam" title="Ceftolozane/tazobactam">Ceftolozane/tazobactam</a></li> <li><a href="/wiki/Imipenem/cilastatin" title="Imipenem/cilastatin">Imipenem/cilastatin</a><sup>#</sup></li> <li><a href="/wiki/Imipenem/cilastatin/relebactam" title="Imipenem/cilastatin/relebactam">Imipenem/cilastatin/relebactam</a></li> <li><a href="/wiki/Meropenem/vaborbactam" title="Meropenem/vaborbactam">Meropenem/vaborbactam</a></li> <li><a href="/wiki/Panipenem/betamipron" title="Panipenem/betamipron">Panipenem/betamipron</a></li> <li><a href="/wiki/Piperacillin/tazobactam" title="Piperacillin/tazobactam">Piperacillin/tazobactam</a></li> <li><a href="/wiki/Sulbactam/durlobactam" title="Sulbactam/durlobactam">Sulbactam/durlobactam</a></li> <li><a href="/wiki/Sulopenem/probenecid" title="Sulopenem/probenecid">Sulopenem/probenecid</a></li> <li><a href="/wiki/Ticarcillin/clavulanic_acid" title="Ticarcillin/clavulanic acid">Ticarcillin/clavulanic acid</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Polypeptide_antibiotic" title="Polypeptide antibiotic">Polypeptides</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Lipopeptide" title="Lipopeptide">Lipopeptides</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Insert into bacterial cell wall causing perforation and depolarization: <a href="/wiki/Daptomycin" title="Daptomycin">Daptomycin</a></li> <li><a href="/wiki/Surfactin" title="Surfactin">Surfactin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Inhibits PG elongation and crosslinking: <a href="/wiki/Ramoplanin" title="Ramoplanin">Ramoplanin</a><sup>§</sup></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Intracellular</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Inhibit <a href="/wiki/Peptidoglycan" title="Peptidoglycan">PG</a> subunit synthesis and transport: <a href="/wiki/N-Acetylmuramic_acid" title="N-Acetylmuramic acid">NAM</a> synthesis inhibition (<a href="/wiki/Fosfomycin" title="Fosfomycin">Fosfomycin</a>)</li> <li><a href="/wiki/D-alanine%E2%80%94D-alanine_ligase" title="D-alanine—D-alanine ligase">DADAL</a>/<a href="/wiki/Alanine_racemase" title="Alanine racemase">AR</a> inhibitors (<a href="/wiki/Cycloserine" title="Cycloserine">Cycloserine</a>)</li> <li><a href="/wiki/Bactoprenol" title="Bactoprenol">bactoprenol</a> inhibitors (<a href="/wiki/Bacitracin" title="Bacitracin">Bacitracin</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Hydrolyze NAM-NAG <ul><li><a href="/wiki/Lysozyme" title="Lysozyme">lysozyme</a></li></ul></li> <li><a href="/wiki/Tyrothricin" title="Tyrothricin">Tyrothricin</a> <ul><li><a href="/wiki/Gramicidin" title="Gramicidin">Gramicidin</a></li> <li><a href="/wiki/Tyrocidine" title="Tyrocidine">Tyrocidine</a></li></ul></li> <li><a href="/wiki/Isoniazid" title="Isoniazid">Isoniazid</a><sup>#</sup></li> <li><a href="/wiki/Teixobactin" title="Teixobactin">Teixobactin</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background: transparent; padding: 0px;"><div><div class="hlist"> <ul><li><sup>#</sup><a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">WHO-EM</a></li> <li><sup>‡</sup><a href="/wiki/List_of_withdrawn_drugs" title="List of withdrawn drugs">Withdrawn</a> from market</li> <li><a href="/wiki/Clinical_trial" title="Clinical trial">Clinical trials</a>: <ul><li><sup>†</sup><a href="/wiki/Phases_of_clinical_research#Phase_III" title="Phases of clinical research">Phase III</a></li> <li><sup>§</sup>Never to phase III</li></ul></li></ul> </div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="GSK" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:GSK" title="Template:GSK"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:GSK" title="Template talk:GSK"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:GSK" title="Special:EditPage/Template:GSK"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="GSK" style="font-size:114%;margin:0 4em"><a href="/wiki/GSK_plc" title="GSK plc">GSK</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Subsidiaries</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Current</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/GlaxoSmithKline_Pakistan" class="mw-redirect" title="GlaxoSmithKline Pakistan">GlaxoSmithKline Pakistan</a></li> <li><a href="/wiki/GlaxoSmithKline_Pharmaceuticals_Ltd" class="mw-redirect" title="GlaxoSmithKline Pharmaceuticals Ltd">GlaxoSmithKline Pharmaceuticals Ltd</a></li> <li><a href="/wiki/Stiefel_Laboratories" title="Stiefel Laboratories">Stiefel Laboratories</a></li> <li><a href="/wiki/Tesaro" title="Tesaro">Tesaro</a></li> <li><a href="/wiki/ViiV_Healthcare" title="ViiV Healthcare">ViiV Healthcare</a> (85%)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Former</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Haleon" title="Haleon">Haleon</a></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Predecessors,<br />acquisitions</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Allen_%26_Hanburys" title="Allen & Hanburys">Allen & Hanburys</a></li> <li><a href="/wiki/Beecham_Group" title="Beecham Group">Beecham Group</a></li> <li><a href="/wiki/Block_Drug" title="Block Drug">Block Drug</a></li> <li><a href="/wiki/GSK_plc#Glaxo_Wellcome" title="GSK plc">Burroughs Wellcome</a></li> <li><a href="/wiki/GSK_plc#Glaxo_Wellcome" title="GSK plc">Glaxo</a></li> <li><a href="/wiki/GSK_plc#Glaxo_Wellcome" title="GSK plc">Glaxo Wellcome</a></li> <li><a href="/wiki/Human_Genome_Sciences" title="Human Genome Sciences">Human Genome Sciences</a></li> <li><a href="/wiki/Recherche_et_Industrie_Th%C3%A9rapeutiques" title="Recherche et Industrie Thérapeutiques">Recherche et Industrie Thérapeutiques</a></li> <li><a href="/wiki/Reliant_Pharmaceuticals" title="Reliant Pharmaceuticals">Reliant Pharmaceuticals</a></li> <li><a href="/wiki/S._E._Massengill_Company" title="S. E. Massengill Company">S. E. Massengill Company</a></li> <li><a href="/wiki/GSK_plc#SmithKline_Beecham" title="GSK plc">SmithKline Beecham</a></li> <li><a href="/wiki/Smith,_Kline_%26_French" title="Smith, Kline & French">Smith, Kline & French</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Products</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Current</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Pharma</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fluticasone/salmeterol" title="Fluticasone/salmeterol">Advair</a></li> <li><a href="/wiki/Orlistat" title="Orlistat">Alli</a></li> <li><a class="mw-selflink selflink">Augmentin</a></li> <li><a href="/wiki/Rosiglitazone" title="Rosiglitazone">Avandia</a></li> <li><a href="/wiki/Beclometasone" title="Beclometasone">Beconase</a></li> <li><a href="/wiki/Ibandronic_acid" title="Ibandronic acid">Boniva</a></li> <li><a href="/wiki/Fluticasone_propionate" title="Fluticasone propionate">Flixonase</a></li> <li><a href="/wiki/Topotecan" title="Topotecan">Hycamtin</a></li> <li><a href="/wiki/Lamotrigine" title="Lamotrigine">Lamictal</a></li> <li><a href="/wiki/Paroxetine" title="Paroxetine">Paxil/Seroxat</a></li> <li><a href="/wiki/Piboserod" title="Piboserod">Serlipet</a></li> <li><a href="/wiki/Cimetidine" title="Cimetidine">Tagamet</a></li> <li><a href="/wiki/Salbutamol" title="Salbutamol">Ventolin</a></li> <li><a href="/wiki/Bupropion" title="Bupropion">Wellbutrin/Zyban</a></li> <li><a href="/wiki/Ranitidine" title="Ranitidine">Zantac</a> … <a href="/wiki/List_of_GSK_plc_products" title="List of GSK plc products"><b>more</b></a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Vaccines</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Respiratory_syncytial_virus_vaccine" title="Respiratory syncytial virus vaccine">Arexvy</a></li> <li><a href="/wiki/Bexsero" class="mw-redirect" title="Bexsero">Bexsero</a></li> <li><a href="/wiki/Boostrix" class="mw-redirect" title="Boostrix">Boostrix</a></li> <li><a href="/wiki/Cervarix" title="Cervarix">Cervarix</a></li> <li><a href="/wiki/Engerix-B" class="mw-redirect" title="Engerix-B">Engerix-B </a></li> <li><a href="/wiki/Fluarix" class="mw-redirect" title="Fluarix">Fluarix</a></li> <li><a href="/wiki/FluLaval" class="mw-redirect" title="FluLaval">FluLaval</a></li> <li><a href="/wiki/Havrix" class="mw-redirect" title="Havrix">Havrix</a></li> <li><a href="/wiki/Hepatyrix" class="mw-redirect" title="Hepatyrix">Hepatyrix</a></li> <li><a href="/wiki/Hiberix" class="mw-redirect" title="Hiberix">Hiberix</a></li> <li><a href="/wiki/Infanrix" class="mw-redirect" title="Infanrix">Infanrix</a></li> <li><a href="/wiki/H5N1_vaccine" title="H5N1 vaccine">H5N1 vaccine</a></li> <li><a href="/wiki/Kinrix" class="mw-redirect" title="Kinrix">Kinrix</a></li> <li><a href="/wiki/Menveo" class="mw-redirect" title="Menveo">Menveo</a></li> <li><a href="/wiki/Pandemrix" title="Pandemrix">Pandemrix</a></li> <li><a href="/wiki/Pediarix" class="mw-redirect" title="Pediarix">Pediarix</a></li> <li><a href="/wiki/Rabavert" class="mw-redirect" title="Rabavert">Rabavert</a></li> <li><a href="/wiki/Rotarix" class="mw-redirect" title="Rotarix">Rotarix</a></li> <li><a href="/wiki/Zoster_vaccine#Shingrix" title="Zoster vaccine">Shingrix</a></li> <li><a href="/wiki/Hepatitis_A_and_B_vaccine" title="Hepatitis A and B vaccine">Twinrix</a> … <a href="/wiki/List_of_GSK_plc_products" title="List of GSK plc products"><b>more</b></a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Former</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Actifed" title="Actifed">Actifed</a></li> <li>Advil</li> <li><a href="/wiki/Aquafresh" class="mw-redirect" title="Aquafresh">Aquafresh</a></li> <li><a href="/wiki/BC_Powder" title="BC Powder">BC Powder</a></li> <li><a href="/wiki/Biotene" title="Biotene">Biotene</a></li> <li><a href="/wiki/Caltrate" title="Caltrate">Caltrate</a></li> <li><a href="/wiki/Centrum_(multivitamin)" title="Centrum (multivitamin)">Centrum</a></li> <li><a href="/wiki/ChapStick" title="ChapStick">ChapStick</a></li> <li><a href="/wiki/Emergen-C" title="Emergen-C">Emergen-C</a></li> <li><a href="/wiki/Eno_(drug)" title="Eno (drug)">Eno</a></li> <li><a href="/wiki/Excedrin_(brand)" title="Excedrin (brand)">Excedrin</a></li> <li>Flonase</li> <li><a href="/wiki/Geritol" title="Geritol">Geritol</a></li> <li><a href="/wiki/Goody%27s_Powder" title="Goody's Powder">Goody's Powder</a></li> <li><a href="/wiki/Horlicks" title="Horlicks">Horlicks</a></li> <li><a href="/wiki/Lucozade" title="Lucozade">Lucozade</a></li> <li><a href="/wiki/Nicoderm" class="mw-redirect" title="Nicoderm">Nicoderm</a></li> <li><a href="/wiki/Nicorette" title="Nicorette">Nicorette</a></li> <li><a href="/wiki/Niquitin" title="Niquitin">NiQuitin</a></li> <li><a href="/wiki/Parodontax" title="Parodontax">Parodontax</a></li> <li><a href="/wiki/Ribena" title="Ribena">Ribena</a></li> <li><a href="/wiki/Sensodyne" title="Sensodyne">Sensodyne</a></li> <li><a href="/wiki/Tums" title="Tums">Tums</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">People</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Board of <br />Directors</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Philip_Hampton" title="Philip Hampton">Philip Hampton</a></li> <li><a href="/wiki/Emma_Walmsley" title="Emma Walmsley">Emma Walmsley</a></li> <li><a href="/wiki/Simon_Dingemans" title="Simon Dingemans">Simon Dingemans</a></li> <li><a href="/wiki/Roy_M._Anderson" title="Roy M. Anderson">Roy M. Anderson</a></li> <li><a href="/wiki/M._S._Banga" title="M. S. Banga">Manvinder Banga</a></li> <li><a href="/wiki/Patrick_Vallance" title="Patrick Vallance">Patrick Vallance</a></li> <li><a href="/wiki/Vivienne_Cox" title="Vivienne Cox">Vivienne Cox</a></li> <li><a href="/wiki/Lynn_Elsenhans" title="Lynn Elsenhans">Lynn Elsenhans</a></li> <li>Jesse Goodman</li> <li><a href="/wiki/Judy_Lewent" title="Judy Lewent">Judy Lewent</a></li> <li><a href="/wiki/Urs_Rohner" title="Urs Rohner">Urs Rohner</a></li> <li><a href="/wiki/Laurie_Glimcher" title="Laurie Glimcher">Laurie Glimcher</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Thomas_Beecham_(chemist)" title="Thomas Beecham (chemist)">Thomas Beecham</a></li> <li><a href="/wiki/Silas_M._Burroughs_(pharmacist)" title="Silas M. Burroughs (pharmacist)">Silas M. Burroughs</a></li> <li><a href="/wiki/Mahlon_Kline" title="Mahlon Kline">Mahlon Kline</a></li> <li><a href="/wiki/John_K._Smith" title="John K. Smith">John K. Smith</a></li> <li><a href="/wiki/Henry_Wellcome" title="Henry Wellcome">Henry Wellcome</a></li> <li><a href="/wiki/Andrew_Witty" title="Andrew Witty">Andrew Witty</a></li> <li><a href="/wiki/Chris_Gent" title="Chris Gent">Chris Gent</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Litigation</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Canada_v._GlaxoSmithKline_Inc." class="mw-redirect" title="Canada v. GlaxoSmithKline Inc.">Canada v. GlaxoSmithKline Inc.</a></i></li> <li><i><a href="/wiki/Christopher_v._SmithKline_Beecham_Corp." title="Christopher v. SmithKline Beecham Corp.">Christopher v. SmithKline Beecham Corp.</a></i></li> <li><i><a href="/wiki/GlaxoSmithKline_Services_Unlimited_v_Commission" title="GlaxoSmithKline Services Unlimited v Commission">GlaxoSmithKline Services Unlimited v Commission</a></i></li> <li><i><a href="/wiki/United_States_v._Glaxo_Group_Ltd." title="United States v. Glaxo Group Ltd.">United States v. Glaxo Group Ltd.</a></i></li> <li><i><a href="/wiki/United_States_v._GlaxoSmithKline" title="United States v. GlaxoSmithKline">United States v. GlaxoSmithKline</a></i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Drug_Industry_Documents_Archive" title="Drug Industry Documents Archive">Drug Industry Documents Archive</a></li> <li><a href="/wiki/GlaxoSmithKline_Prize" title="GlaxoSmithKline Prize">GlaxoSmithKline Prize</a></li> <li><i><a href="/wiki/Side_Effects_(Bass_book)" title="Side Effects (Bass book)">Side Effects</a></i></li> <li><a href="/wiki/Study_329" title="Study 329">Study 329</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <ul><li><span class="noviewer" typeof="mw:File"><span title="Category"><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/9/96/Symbol_category_class.svg/16px-Symbol_category_class.svg.png" decoding="async" width="16" height="16" class="mw-file-element" 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