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data-dom-id="Pill-react-component-0ab46543-ad88-4f87-9816-c143da2926e7"></div> <div id="Pill-react-component-0ab46543-ad88-4f87-9816-c143da2926e7"></div> </a></div></div><div class="external-links-container"><ul class="profile-links new-profile js-UserInfo-social"><li class="profile-profiles js-social-profiles-container"><i class="fa fa-spin fa-spinner"></i></li></ul></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Ivan Marquez</h3></div><div class="js-work-strip profile--work_container" data-work-id="103872611"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103872611/Cancer_immunotherapy_in_special_challenging_populations_recommendations_of_the_Advisory_Committee_of_Spanish_Melanoma_Group_GEM_"><img alt="Research paper thumbnail of Cancer immunotherapy in special challenging populations: recommendations of the Advisory Committee of Spanish Melanoma Group (GEM)" class="work-thumbnail" src="https://attachments.academia-assets.com/103757400/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103872611/Cancer_immunotherapy_in_special_challenging_populations_recommendations_of_the_Advisory_Committee_of_Spanish_Melanoma_Group_GEM_">Cancer immunotherapy in special challenging populations: recommendations of the Advisory Committee of Spanish Melanoma Group (GEM)</a></div><div class="wp-workCard_item"><span>Journal for ImmunoTherapy of Cancer</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cancer immunotherapy based on the use of antibodies targeting the so-called checkpoint inhibitors...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cancer immunotherapy based on the use of antibodies targeting the so-called checkpoint inhibitors, such as programmed cell death-1 receptor, its ligand, or CTLA-4, has shown durable clinical benefit and survival improvement in melanoma and other tumors. However, there are some special situations that could be a challenge for clinical management. Persons with chronic infections, such as HIV-1 or viral hepatitis, latent tuberculosis, or a history of solid organ transplantation, could be candidates for cancer immunotherapy, but their management requires a multidisciplinary approach. The Spanish Melanoma Group (GEM) panel in collaboration with experts in virology and immunology from different centers in Spain reviewed the literature and developed evidence-based guidelines for cancer immunotherapy management in patients with chronic infections and immunosuppression. These are the first clinical guidelines for cancer immunotherapy treatment in special challenging populations. Cancer immun...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6e4e8e4f5442289d91a5b89867582f5b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103757400,"asset_id":103872611,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103757400/download_file?st=MTczMjgxMjQ2MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103872611"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103872611"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103872611; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=103872611]").text(description); $(".js-view-count[data-work-id=103872611]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 103872611; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='103872611']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 103872611, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6e4e8e4f5442289d91a5b89867582f5b" } } $('.js-work-strip[data-work-id=103872611]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":103872611,"title":"Cancer immunotherapy in special challenging populations: recommendations of the Advisory Committee of Spanish Melanoma Group (GEM)","translated_title":"","metadata":{"abstract":"Cancer immunotherapy based on the use of antibodies targeting the so-called checkpoint inhibitors, such as programmed cell death-1 receptor, its ligand, or CTLA-4, has shown durable clinical benefit and survival improvement in melanoma and other tumors. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103872610"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103872610/Adjuvant_nivolumab_for_stage_III_IV_melanoma_evaluation_of_safety_outcomes_and_association_with_recurrence_free_survival"><img alt="Research paper thumbnail of Adjuvant nivolumab for stage III/IV melanoma: evaluation of safety outcomes and association with recurrence-free survival" class="work-thumbnail" src="https://attachments.academia-assets.com/103757391/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103872610/Adjuvant_nivolumab_for_stage_III_IV_melanoma_evaluation_of_safety_outcomes_and_association_with_recurrence_free_survival">Adjuvant nivolumab for stage III/IV melanoma: evaluation of safety outcomes and association with recurrence-free survival</a></div><div class="wp-workCard_item"><span>Journal for ImmunoTherapy of Cancer</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BackgroundSeveral therapeutic options are now available in the adjuvant melanoma setting, mandati...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BackgroundSeveral therapeutic options are now available in the adjuvant melanoma setting, mandating an understanding of their benefit‒risk profiles in order to make informed treatment decisions. Herein we characterize adjuvant nivolumab select (immune-related) treatment-related adverse events (TRAEs) and evaluate possible associations between safety and recurrence-free survival (RFS) in the phase III CheckMate 238 trial.MethodsPatients with resected stage IIIB–C or IV melanoma received nivolumab 3 mg/kg every 2 weeks (n=452) or ipilimumab 10 mg/kg every 3 weeks for four doses and then every 12 weeks (n=453) for up to 1 year or until disease recurrence, unacceptable toxicity, or consent withdrawal. First-occurrence and all-occurrence select TRAEs were analyzed within discrete time intervals: from 0 to 3 months of treatment, from &gt;3–12 months of treatment, and from the last dose (regardless of early or per-protocol treatment discontinuation) to 100 days after the last dose. Possibl...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="82af17ee7bca55365025d39697e75b55" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103757391,"asset_id":103872610,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103757391/download_file?st=MTczMjgxMjQ2MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103872610"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103872610"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103872610; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=103872610]").text(description); $(".js-view-count[data-work-id=103872610]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 103872610; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='103872610']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 103872610, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "82af17ee7bca55365025d39697e75b55" } } $('.js-work-strip[data-work-id=103872610]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":103872610,"title":"Adjuvant nivolumab for stage III/IV melanoma: evaluation of safety outcomes and association with recurrence-free survival","translated_title":"","metadata":{"abstract":"BackgroundSeveral therapeutic options are now available in the adjuvant melanoma setting, mandating an understanding of their benefit‒risk profiles in order to make informed treatment decisions. Herein we characterize adjuvant nivolumab select (immune-related) treatment-related adverse events (TRAEs) and evaluate possible associations between safety and recurrence-free survival (RFS) in the phase III CheckMate 238 trial.MethodsPatients with resected stage IIIB–C or IV melanoma received nivolumab 3 mg/kg every 2 weeks (n=452) or ipilimumab 10 mg/kg every 3 weeks for four doses and then every 12 weeks (n=453) for up to 1 year or until disease recurrence, unacceptable toxicity, or consent withdrawal. First-occurrence and all-occurrence select TRAEs were analyzed within discrete time intervals: from 0 to 3 months of treatment, from \u0026gt;3–12 months of treatment, and from the last dose (regardless of early or per-protocol treatment discontinuation) to 100 days after the last dose. Possibl...","publisher":"BMJ","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Journal for ImmunoTherapy of Cancer"},"translated_abstract":"BackgroundSeveral therapeutic options are now available in the adjuvant melanoma setting, mandating an understanding of their benefit‒risk profiles in order to make informed treatment decisions. Herein we characterize adjuvant nivolumab select (immune-related) treatment-related adverse events (TRAEs) and evaluate possible associations between safety and recurrence-free survival (RFS) in the phase III CheckMate 238 trial.MethodsPatients with resected stage IIIB–C or IV melanoma received nivolumab 3 mg/kg every 2 weeks (n=452) or ipilimumab 10 mg/kg every 3 weeks for four doses and then every 12 weeks (n=453) for up to 1 year or until disease recurrence, unacceptable toxicity, or consent withdrawal. 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Possibl...","internal_url":"https://www.academia.edu/103872610/Adjuvant_nivolumab_for_stage_III_IV_melanoma_evaluation_of_safety_outcomes_and_association_with_recurrence_free_survival","translated_internal_url":"","created_at":"2023-06-25T23:01:23.162-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":274960877,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":103757391,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/103757391/thumbnails/1.jpg","file_name":"e003188.full.pdf","download_url":"https://www.academia.edu/attachments/103757391/download_file?st=MTczMjgxMjQ2MSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Adjuvant_nivolumab_for_stage_III_IV_mela.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/103757391/e003188.full-libre.pdf?1687762761=\u0026response-content-disposition=attachment%3B+filename%3DAdjuvant_nivolumab_for_stage_III_IV_mela.pdf\u0026Expires=1732816061\u0026Signature=I5SlJV~gVCWmDHGnbpmgprdMHXvVuUVb2Tlm02xKbJbTdcVE3ifkmLEcVOMqnortK6YCZvQ1oRqeWytF28lpZ6isJM1V8f30OivxsblBgWkWSkA5Oxk87jQZAcxqfnt9YSpLLYdbSDqN06GFUL7TWkWhDT5ttQrclCtez2n~ZG2yOrD2NQ9cCIL3yxmEahBjuYjvqm085Q5DH50UjBV7uzToOM-NrLH3CPA-CH6BXDgo4CgUdNjWPnBJH8GnbIeBbwhoOEtZ1dOVPcZ7fwbC164GK2Gdywe4mxEPbNGL99UTOwRDnvFXRP6-CyZ3ZLq2P6tqX-qXjw-eRJPodOyJVA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Adjuvant_nivolumab_for_stage_III_IV_melanoma_evaluation_of_safety_outcomes_and_association_with_recurrence_free_survival","translated_slug":"","page_count":38,"language":"en","content_type":"Work","owner":{"id":274960877,"first_name":"Ivan","middle_initials":null,"last_name":"Marquez","page_name":"IvanMarquez147","domain_name":"independent","created_at":"2023-06-25T23:00:52.945-07:00","display_name":"Ivan Marquez","url":"https://independent.academia.edu/IvanMarquez147"},"attachments":[{"id":103757391,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/103757391/thumbnails/1.jpg","file_name":"e003188.full.pdf","download_url":"https://www.academia.edu/attachments/103757391/download_file?st=MTczMjgxMjQ2MSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Adjuvant_nivolumab_for_stage_III_IV_mela.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/103757391/e003188.full-libre.pdf?1687762761=\u0026response-content-disposition=attachment%3B+filename%3DAdjuvant_nivolumab_for_stage_III_IV_mela.pdf\u0026Expires=1732816061\u0026Signature=I5SlJV~gVCWmDHGnbpmgprdMHXvVuUVb2Tlm02xKbJbTdcVE3ifkmLEcVOMqnortK6YCZvQ1oRqeWytF28lpZ6isJM1V8f30OivxsblBgWkWSkA5Oxk87jQZAcxqfnt9YSpLLYdbSDqN06GFUL7TWkWhDT5ttQrclCtez2n~ZG2yOrD2NQ9cCIL3yxmEahBjuYjvqm085Q5DH50UjBV7uzToOM-NrLH3CPA-CH6BXDgo4CgUdNjWPnBJH8GnbIeBbwhoOEtZ1dOVPcZ7fwbC164GK2Gdywe4mxEPbNGL99UTOwRDnvFXRP6-CyZ3ZLq2P6tqX-qXjw-eRJPodOyJVA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":626,"name":"Oncology","url":"https://www.academia.edu/Documents/in/Oncology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":232914,"name":"Ipilimumab","url":"https://www.academia.edu/Documents/in/Ipilimumab"},{"id":1485245,"name":"Adjuvant","url":"https://www.academia.edu/Documents/in/Adjuvant"},{"id":2601211,"name":"Adverse effect","url":"https://www.academia.edu/Documents/in/Adverse_effect"},{"id":3331893,"name":"discontinuation","url":"https://www.academia.edu/Documents/in/discontinuation"},{"id":3571747,"name":"Nivolumab","url":"https://www.academia.edu/Documents/in/Nivolumab"}],"urls":[{"id":32532587,"url":"https://syndication.highwire.org/content/doi/10.1136/jitc-2021-003188"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103872608"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103872608/A_Framework_for_Addressing_Diabetes_Related_Disparities_in_US_Latino_Populations"><img alt="Research paper thumbnail of A Framework for Addressing Diabetes-Related Disparities in US Latino Populations" class="work-thumbnail" src="https://attachments.academia-assets.com/103757393/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103872608/A_Framework_for_Addressing_Diabetes_Related_Disparities_in_US_Latino_Populations">A Framework for Addressing Diabetes-Related Disparities in US Latino Populations</a></div><div class="wp-workCard_item"><span>Journal of community health</span><span>, Jan 27, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Despite national efforts to redress racial/ethnic disparities, Latino Americans continue to share...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Despite national efforts to redress racial/ethnic disparities, Latino Americans continue to share a disproportionate burden of diabetes-related morbidity and mortality. A better understanding of underlying causes and influencing factors is needed to guide future efforts to eliminate racial/ethnic disparities in diabetes control. The objectives of this review are: (1) to summarize our understanding of determinants and modifiable predictors of glycemic control; (2) to provide an overview of existing strategies to reduce diabetes-related disparities; and (3) to identify gaps in the literature regarding whether these interventions effectively address disparities in US Latino populations. Key findings include evidence that diabetes care services can be designed to accommodate heterogeneity within the Latino American community by addressing key modifiable predictors of poor glycemic control, including insurance status, diabetes care utilization, patient self-management, language access, c...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e0708634183140b99bda8945b01a356c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103757393,"asset_id":103872608,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103757393/download_file?st=MTczMjgxMjQ2MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103872608"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103872608"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103872608; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=103872608]").text(description); $(".js-view-count[data-work-id=103872608]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 103872608; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='103872608']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 103872608, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e0708634183140b99bda8945b01a356c" } } $('.js-work-strip[data-work-id=103872608]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":103872608,"title":"A Framework for Addressing Diabetes-Related Disparities in US Latino Populations","translated_title":"","metadata":{"abstract":"Despite national efforts to redress racial/ethnic disparities, Latino Americans continue to share a disproportionate burden of diabetes-related morbidity and mortality. A better understanding of underlying causes and influencing factors is needed to guide future efforts to eliminate racial/ethnic disparities in diabetes control. The objectives of this review are: (1) to summarize our understanding of determinants and modifiable predictors of glycemic control; (2) to provide an overview of existing strategies to reduce diabetes-related disparities; and (3) to identify gaps in the literature regarding whether these interventions effectively address disparities in US Latino populations. Key findings include evidence that diabetes care services can be designed to accommodate heterogeneity within the Latino American community by addressing key modifiable predictors of poor glycemic control, including insurance status, diabetes care utilization, patient self-management, language access, c...","publication_date":{"day":27,"month":1,"year":2018,"errors":{}},"publication_name":"Journal of community health"},"translated_abstract":"Despite national efforts to redress racial/ethnic disparities, Latino Americans continue to share a disproportionate burden of diabetes-related morbidity and mortality. A better understanding of underlying causes and influencing factors is needed to guide future efforts to eliminate racial/ethnic disparities in diabetes control. The objectives of this review are: (1) to summarize our understanding of determinants and modifiable predictors of glycemic control; (2) to provide an overview of existing strategies to reduce diabetes-related disparities; and (3) to identify gaps in the literature regarding whether these interventions effectively address disparities in US Latino populations. Key findings include evidence that diabetes care services can be designed to accommodate heterogeneity within the Latino American community by addressing key modifiable predictors of poor glycemic control, including insurance status, diabetes care utilization, patient self-management, language access, c...","internal_url":"https://www.academia.edu/103872608/A_Framework_for_Addressing_Diabetes_Related_Disparities_in_US_Latino_Populations","translated_internal_url":"","created_at":"2023-06-25T23:01:22.998-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":274960877,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":103757393,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/103757393/thumbnails/1.jpg","file_name":"s10900-018-0574-120230626-1-cli5hg.pdf","download_url":"https://www.academia.edu/attachments/103757393/download_file?st=MTczMjgxMjQ2MSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_Framework_for_Addressing_Diabetes_Rela.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/103757393/s10900-018-0574-120230626-1-cli5hg-libre.pdf?1687762730=\u0026response-content-disposition=attachment%3B+filename%3DA_Framework_for_Addressing_Diabetes_Rela.pdf\u0026Expires=1732816061\u0026Signature=EqbNnl3iiwau8JMklecI8sYM3otLFAAlY1HrjsWNLlAPWhLt1msc1mOEL7QbqNDD6TiUVyTO~vPDvScR0mdtr-z-aWpzCgQaIXnbABFcp86Ga3cuXQ7V9TmHioy27KKak0ef9JJ1mwfer6PQOTJ0sgCaSqo0rcOuXSruo7HfVhSuQj6q0TaPTQwZNPwNTQd5JfO5cujBNgGp4J5yg-9Ev89btB48c4PxALIKUf0Rgg0RNTf456Al2bX23F~EUxlBHHgc-e6vNS2nJ6yp29zr94fTe-5v8u60P1RXBZQCvV5-yRLqu0wTwdp-Uw4MT47J1f4J0FH22~viZ-WCWciZGg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_Framework_for_Addressing_Diabetes_Related_Disparities_in_US_Latino_Populations","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":274960877,"first_name":"Ivan","middle_initials":null,"last_name":"Marquez","page_name":"IvanMarquez147","domain_name":"independent","created_at":"2023-06-25T23:00:52.945-07:00","display_name":"Ivan Marquez","url":"https://independent.academia.edu/IvanMarquez147"},"attachments":[{"id":103757393,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/103757393/thumbnails/1.jpg","file_name":"s10900-018-0574-120230626-1-cli5hg.pdf","download_url":"https://www.academia.edu/attachments/103757393/download_file?st=MTczMjgxMjQ2MSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_Framework_for_Addressing_Diabetes_Rela.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/103757393/s10900-018-0574-120230626-1-cli5hg-libre.pdf?1687762730=\u0026response-content-disposition=attachment%3B+filename%3DA_Framework_for_Addressing_Diabetes_Rela.pdf\u0026Expires=1732816061\u0026Signature=EqbNnl3iiwau8JMklecI8sYM3otLFAAlY1HrjsWNLlAPWhLt1msc1mOEL7QbqNDD6TiUVyTO~vPDvScR0mdtr-z-aWpzCgQaIXnbABFcp86Ga3cuXQ7V9TmHioy27KKak0ef9JJ1mwfer6PQOTJ0sgCaSqo0rcOuXSruo7HfVhSuQj6q0TaPTQwZNPwNTQd5JfO5cujBNgGp4J5yg-9Ev89btB48c4PxALIKUf0Rgg0RNTf456Al2bX23F~EUxlBHHgc-e6vNS2nJ6yp29zr94fTe-5v8u60P1RXBZQCvV5-yRLqu0wTwdp-Uw4MT47J1f4J0FH22~viZ-WCWciZGg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":11435,"name":"Community Health","url":"https://www.academia.edu/Documents/in/Community_Health"},{"id":13085,"name":"Health Equity","url":"https://www.academia.edu/Documents/in/Health_Equity"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":48655,"name":"Redress","url":"https://www.academia.edu/Documents/in/Redress"},{"id":116278,"name":"Psychological Intervention","url":"https://www.academia.edu/Documents/in/Psychological_Intervention"},{"id":179865,"name":"Glycemic Index","url":"https://www.academia.edu/Documents/in/Glycemic_Index"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1"},{"id":413189,"name":"Ethnic Group","url":"https://www.academia.edu/Documents/in/Ethnic_Group"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103872607"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103872607/Using_Enhanced_Primary_Care_Services_in_High_risk_Latino_Populations_to_Reduce_Disparities_in_Glycemic_Control"><img alt="Research paper thumbnail of Using Enhanced Primary Care Services in High-risk Latino Populations to Reduce Disparities in Glycemic Control" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103872607/Using_Enhanced_Primary_Care_Services_in_High_risk_Latino_Populations_to_Reduce_Disparities_in_Glycemic_Control">Using Enhanced Primary Care Services in High-risk Latino Populations to Reduce Disparities in Glycemic Control</a></div><div class="wp-workCard_item"><span>Journal of health care for the poor and underserved</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To determine whether enhanced primary care services delivered preferentially to high-risk patient...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To determine whether enhanced primary care services delivered preferentially to high-risk patients with diabetes (HbA1c &gt;9%) can effectively reduce racial/ethnic disparities in glycemic control. This retrospective study analyzed electronic health records to examine changes in pre-vs. post-intervention disparities in HbA1c among Hispanics/Latinos relative to non-Hispanic Whites. Mean HbA1c and prevalence of poorly controlled diabetes improved in both racial/ethnic groups, but to a greater extent among Hispanics/Latinos. Mean HbA1c dropped 0.43 points further among Hispanics/Latinos than non-Hispanic Whites (95% CI, - 0.57 to - 0.29, p&lt;.001). The change in disparity in prevalence of poorly controlled diabetes, measured as the ratio of post-vs. pre-intervention prevalence ratios, was 0.89 (95% CI, 0.84 to 0.94, p&lt;.001). Both measures indicated greater reduction among Hispanics/Latinos relative to non-Hispanic Whites. Enhanced primary care services directed at high-risk patient...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103872607"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103872607"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103872607; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=103872607]").text(description); $(".js-view-count[data-work-id=103872607]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 103872607; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='103872607']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 103872607, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=103872607]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":103872607,"title":"Using Enhanced Primary Care Services in High-risk Latino Populations to Reduce Disparities in Glycemic Control","translated_title":"","metadata":{"abstract":"To determine whether enhanced primary care services delivered preferentially to high-risk patients with diabetes (HbA1c \u0026gt;9%) can effectively reduce racial/ethnic disparities in glycemic control. This retrospective study analyzed electronic health records to examine changes in pre-vs. post-intervention disparities in HbA1c among Hispanics/Latinos relative to non-Hispanic Whites. Mean HbA1c and prevalence of poorly controlled diabetes improved in both racial/ethnic groups, but to a greater extent among Hispanics/Latinos. Mean HbA1c dropped 0.43 points further among Hispanics/Latinos than non-Hispanic Whites (95% CI, - 0.57 to - 0.29, p\u0026lt;.001). The change in disparity in prevalence of poorly controlled diabetes, measured as the ratio of post-vs. pre-intervention prevalence ratios, was 0.89 (95% CI, 0.84 to 0.94, p\u0026lt;.001). Both measures indicated greater reduction among Hispanics/Latinos relative to non-Hispanic Whites. Enhanced primary care services directed at high-risk patient...","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Journal of health care for the poor and underserved"},"translated_abstract":"To determine whether enhanced primary care services delivered preferentially to high-risk patients with diabetes (HbA1c \u0026gt;9%) can effectively reduce racial/ethnic disparities in glycemic control. This retrospective study analyzed electronic health records to examine changes in pre-vs. post-intervention disparities in HbA1c among Hispanics/Latinos relative to non-Hispanic Whites. Mean HbA1c and prevalence of poorly controlled diabetes improved in both racial/ethnic groups, but to a greater extent among Hispanics/Latinos. Mean HbA1c dropped 0.43 points further among Hispanics/Latinos than non-Hispanic Whites (95% CI, - 0.57 to - 0.29, p\u0026lt;.001). The change in disparity in prevalence of poorly controlled diabetes, measured as the ratio of post-vs. pre-intervention prevalence ratios, was 0.89 (95% CI, 0.84 to 0.94, p\u0026lt;.001). Both measures indicated greater reduction among Hispanics/Latinos relative to non-Hispanic Whites. Enhanced primary care services directed at high-risk patient...","internal_url":"https://www.academia.edu/103872607/Using_Enhanced_Primary_Care_Services_in_High_risk_Latino_Populations_to_Reduce_Disparities_in_Glycemic_Control","translated_internal_url":"","created_at":"2023-06-25T23:01:22.833-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":274960877,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Using_Enhanced_Primary_Care_Services_in_High_risk_Latino_Populations_to_Reduce_Disparities_in_Glycemic_Control","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":274960877,"first_name":"Ivan","middle_initials":null,"last_name":"Marquez","page_name":"IvanMarquez147","domain_name":"independent","created_at":"2023-06-25T23:00:52.945-07:00","display_name":"Ivan Marquez","url":"https://independent.academia.edu/IvanMarquez147"},"attachments":[],"research_interests":[{"id":633,"name":"Primary Care","url":"https://www.academia.edu/Documents/in/Primary_Care"},{"id":13085,"name":"Health Equity","url":"https://www.academia.edu/Documents/in/Health_Equity"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus"},{"id":179865,"name":"Glycemic Index","url":"https://www.academia.edu/Documents/in/Glycemic_Index"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1"},{"id":413189,"name":"Ethnic Group","url":"https://www.academia.edu/Documents/in/Ethnic_Group"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="18195308" id="papers"><div class="js-work-strip profile--work_container" data-work-id="103872611"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103872611/Cancer_immunotherapy_in_special_challenging_populations_recommendations_of_the_Advisory_Committee_of_Spanish_Melanoma_Group_GEM_"><img alt="Research paper thumbnail of Cancer immunotherapy in special challenging populations: recommendations of the Advisory Committee of Spanish Melanoma Group (GEM)" class="work-thumbnail" src="https://attachments.academia-assets.com/103757400/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103872611/Cancer_immunotherapy_in_special_challenging_populations_recommendations_of_the_Advisory_Committee_of_Spanish_Melanoma_Group_GEM_">Cancer immunotherapy in special challenging populations: recommendations of the Advisory Committee of Spanish Melanoma Group (GEM)</a></div><div class="wp-workCard_item"><span>Journal for ImmunoTherapy of Cancer</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cancer immunotherapy based on the use of antibodies targeting the so-called checkpoint inhibitors...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cancer immunotherapy based on the use of antibodies targeting the so-called checkpoint inhibitors, such as programmed cell death-1 receptor, its ligand, or CTLA-4, has shown durable clinical benefit and survival improvement in melanoma and other tumors. However, there are some special situations that could be a challenge for clinical management. Persons with chronic infections, such as HIV-1 or viral hepatitis, latent tuberculosis, or a history of solid organ transplantation, could be candidates for cancer immunotherapy, but their management requires a multidisciplinary approach. The Spanish Melanoma Group (GEM) panel in collaboration with experts in virology and immunology from different centers in Spain reviewed the literature and developed evidence-based guidelines for cancer immunotherapy management in patients with chronic infections and immunosuppression. These are the first clinical guidelines for cancer immunotherapy treatment in special challenging populations. Cancer immun...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6e4e8e4f5442289d91a5b89867582f5b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103757400,"asset_id":103872611,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103757400/download_file?st=MTczMjgxMjQ2MSw4LjIyMi4yMDguMTQ2&st=MTczMjgxMjQ2MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103872611"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103872611"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103872611; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=103872611]").text(description); $(".js-view-count[data-work-id=103872611]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 103872611; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='103872611']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 103872611, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6e4e8e4f5442289d91a5b89867582f5b" } } $('.js-work-strip[data-work-id=103872611]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":103872611,"title":"Cancer immunotherapy in special challenging populations: recommendations of the Advisory Committee of Spanish Melanoma Group (GEM)","translated_title":"","metadata":{"abstract":"Cancer immunotherapy based on the use of antibodies targeting the so-called checkpoint inhibitors, such as programmed cell death-1 receptor, its ligand, or CTLA-4, has shown durable clinical benefit and survival improvement in melanoma and other tumors. However, there are some special situations that could be a challenge for clinical management. Persons with chronic infections, such as HIV-1 or viral hepatitis, latent tuberculosis, or a history of solid organ transplantation, could be candidates for cancer immunotherapy, but their management requires a multidisciplinary approach. The Spanish Melanoma Group (GEM) panel in collaboration with experts in virology and immunology from different centers in Spain reviewed the literature and developed evidence-based guidelines for cancer immunotherapy management in patients with chronic infections and immunosuppression. These are the first clinical guidelines for cancer immunotherapy treatment in special challenging populations. Cancer immun...","publisher":"BMJ","publication_name":"Journal for ImmunoTherapy of Cancer"},"translated_abstract":"Cancer immunotherapy based on the use of antibodies targeting the so-called checkpoint inhibitors, such as programmed cell death-1 receptor, its ligand, or CTLA-4, has shown durable clinical benefit and survival improvement in melanoma and other tumors. However, there are some special situations that could be a challenge for clinical management. Persons with chronic infections, such as HIV-1 or viral hepatitis, latent tuberculosis, or a history of solid organ transplantation, could be candidates for cancer immunotherapy, but their management requires a multidisciplinary approach. The Spanish Melanoma Group (GEM) panel in collaboration with experts in virology and immunology from different centers in Spain reviewed the literature and developed evidence-based guidelines for cancer immunotherapy management in patients with chronic infections and immunosuppression. These are the first clinical guidelines for cancer immunotherapy treatment in special challenging populations. Cancer immun...","internal_url":"https://www.academia.edu/103872611/Cancer_immunotherapy_in_special_challenging_populations_recommendations_of_the_Advisory_Committee_of_Spanish_Melanoma_Group_GEM_","translated_internal_url":"","created_at":"2023-06-25T23:01:23.413-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":274960877,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":103757400,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/103757400/thumbnails/1.jpg","file_name":"e001664.full.pdf","download_url":"https://www.academia.edu/attachments/103757400/download_file?st=MTczMjgxMjQ2MSw4LjIyMi4yMDguMTQ2&st=MTczMjgxMjQ2MSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cancer_immunotherapy_in_special_challeng.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/103757400/e001664.full-libre.pdf?1687762736=\u0026response-content-disposition=attachment%3B+filename%3DCancer_immunotherapy_in_special_challeng.pdf\u0026Expires=1732816061\u0026Signature=MWYd5tnfBz0NUw1ZI9MGZr-fXMY80CQ8KfgY54XrEAu~FT2G6mYILZi-Kfg8P4mkT~xF3ZWIamRvzE1n2IpPx8RyiGiM4NyiVJfhI8UcW~ufiqn59tCxHMBwsnfZJ9WZr2U6gcJdTMXrmE304uVGet0YCik-d~-9s-QBJRUIcOFVCvDCRywP-EjMIjYUE7EITzuejiU-VxldqxocgTajG8xFCtU8jThmHrXHcqNU4WL1GaXKmTzXFSVHxgRlTwB1ZSX4ag-jxGe1qFJLlHP7so9nQuGBx4vHh8kTDs~kbllUhZngwjIXQ~1-3rrX72~6~-asbwaeo3RB-8mmHOjZ8Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Cancer_immunotherapy_in_special_challenging_populations_recommendations_of_the_Advisory_Committee_of_Spanish_Melanoma_Group_GEM_","translated_slug":"","page_count":23,"language":"en","content_type":"Work","owner":{"id":274960877,"first_name":"Ivan","middle_initials":null,"last_name":"Marquez","page_name":"IvanMarquez147","domain_name":"independent","created_at":"2023-06-25T23:00:52.945-07:00","display_name":"Ivan Marquez","url":"https://independent.academia.edu/IvanMarquez147"},"attachments":[{"id":103757400,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/103757400/thumbnails/1.jpg","file_name":"e001664.full.pdf","download_url":"https://www.academia.edu/attachments/103757400/download_file?st=MTczMjgxMjQ2MSw4LjIyMi4yMDguMTQ2&st=MTczMjgxMjQ2MSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cancer_immunotherapy_in_special_challeng.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/103757400/e001664.full-libre.pdf?1687762736=\u0026response-content-disposition=attachment%3B+filename%3DCancer_immunotherapy_in_special_challeng.pdf\u0026Expires=1732816061\u0026Signature=MWYd5tnfBz0NUw1ZI9MGZr-fXMY80CQ8KfgY54XrEAu~FT2G6mYILZi-Kfg8P4mkT~xF3ZWIamRvzE1n2IpPx8RyiGiM4NyiVJfhI8UcW~ufiqn59tCxHMBwsnfZJ9WZr2U6gcJdTMXrmE304uVGet0YCik-d~-9s-QBJRUIcOFVCvDCRywP-EjMIjYUE7EITzuejiU-VxldqxocgTajG8xFCtU8jThmHrXHcqNU4WL1GaXKmTzXFSVHxgRlTwB1ZSX4ag-jxGe1qFJLlHP7so9nQuGBx4vHh8kTDs~kbllUhZngwjIXQ~1-3rrX72~6~-asbwaeo3RB-8mmHOjZ8Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":22103,"name":"Cancer Immunotherapy","url":"https://www.academia.edu/Documents/in/Cancer_Immunotherapy"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":118540,"name":"Immunosuppression","url":"https://www.academia.edu/Documents/in/Immunosuppression"},{"id":126863,"name":"Immunotherapy","url":"https://www.academia.edu/Documents/in/Immunotherapy"}],"urls":[{"id":32532588,"url":"https://syndication.highwire.org/content/doi/10.1136/jitc-2020-001664"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103872610"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103872610/Adjuvant_nivolumab_for_stage_III_IV_melanoma_evaluation_of_safety_outcomes_and_association_with_recurrence_free_survival"><img alt="Research paper thumbnail of Adjuvant nivolumab for stage III/IV melanoma: evaluation of safety outcomes and association with recurrence-free survival" class="work-thumbnail" src="https://attachments.academia-assets.com/103757391/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103872610/Adjuvant_nivolumab_for_stage_III_IV_melanoma_evaluation_of_safety_outcomes_and_association_with_recurrence_free_survival">Adjuvant nivolumab for stage III/IV melanoma: evaluation of safety outcomes and association with recurrence-free survival</a></div><div class="wp-workCard_item"><span>Journal for ImmunoTherapy of Cancer</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BackgroundSeveral therapeutic options are now available in the adjuvant melanoma setting, mandati...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BackgroundSeveral therapeutic options are now available in the adjuvant melanoma setting, mandating an understanding of their benefit‒risk profiles in order to make informed treatment decisions. Herein we characterize adjuvant nivolumab select (immune-related) treatment-related adverse events (TRAEs) and evaluate possible associations between safety and recurrence-free survival (RFS) in the phase III CheckMate 238 trial.MethodsPatients with resected stage IIIB–C or IV melanoma received nivolumab 3 mg/kg every 2 weeks (n=452) or ipilimumab 10 mg/kg every 3 weeks for four doses and then every 12 weeks (n=453) for up to 1 year or until disease recurrence, unacceptable toxicity, or consent withdrawal. First-occurrence and all-occurrence select TRAEs were analyzed within discrete time intervals: from 0 to 3 months of treatment, from &gt;3–12 months of treatment, and from the last dose (regardless of early or per-protocol treatment discontinuation) to 100 days after the last dose. Possibl...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="82af17ee7bca55365025d39697e75b55" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103757391,"asset_id":103872610,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103757391/download_file?st=MTczMjgxMjQ2MSw4LjIyMi4yMDguMTQ2&st=MTczMjgxMjQ2MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103872610"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103872610"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103872610; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=103872610]").text(description); $(".js-view-count[data-work-id=103872610]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 103872610; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='103872610']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 103872610, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "82af17ee7bca55365025d39697e75b55" } } $('.js-work-strip[data-work-id=103872610]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":103872610,"title":"Adjuvant nivolumab for stage III/IV melanoma: evaluation of safety outcomes and association with recurrence-free survival","translated_title":"","metadata":{"abstract":"BackgroundSeveral therapeutic options are now available in the adjuvant melanoma setting, mandating an understanding of their benefit‒risk profiles in order to make informed treatment decisions. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103872608"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103872608/A_Framework_for_Addressing_Diabetes_Related_Disparities_in_US_Latino_Populations"><img alt="Research paper thumbnail of A Framework for Addressing Diabetes-Related Disparities in US Latino Populations" class="work-thumbnail" src="https://attachments.academia-assets.com/103757393/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103872608/A_Framework_for_Addressing_Diabetes_Related_Disparities_in_US_Latino_Populations">A Framework for Addressing Diabetes-Related Disparities in US Latino Populations</a></div><div class="wp-workCard_item"><span>Journal of community health</span><span>, Jan 27, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Despite national efforts to redress racial/ethnic disparities, Latino Americans continue to share...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Despite national efforts to redress racial/ethnic disparities, Latino Americans continue to share a disproportionate burden of diabetes-related morbidity and mortality. A better understanding of underlying causes and influencing factors is needed to guide future efforts to eliminate racial/ethnic disparities in diabetes control. The objectives of this review are: (1) to summarize our understanding of determinants and modifiable predictors of glycemic control; (2) to provide an overview of existing strategies to reduce diabetes-related disparities; and (3) to identify gaps in the literature regarding whether these interventions effectively address disparities in US Latino populations. Key findings include evidence that diabetes care services can be designed to accommodate heterogeneity within the Latino American community by addressing key modifiable predictors of poor glycemic control, including insurance status, diabetes care utilization, patient self-management, language access, c...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e0708634183140b99bda8945b01a356c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103757393,"asset_id":103872608,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103757393/download_file?st=MTczMjgxMjQ2MSw4LjIyMi4yMDguMTQ2&st=MTczMjgxMjQ2MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103872608"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103872608"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103872608; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=103872608]").text(description); $(".js-view-count[data-work-id=103872608]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 103872608; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='103872608']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 103872608, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e0708634183140b99bda8945b01a356c" } } $('.js-work-strip[data-work-id=103872608]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":103872608,"title":"A Framework for Addressing Diabetes-Related Disparities in US Latino Populations","translated_title":"","metadata":{"abstract":"Despite national efforts to redress racial/ethnic disparities, Latino Americans continue to share a disproportionate burden of diabetes-related morbidity and mortality. 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The objectives of this review are: (1) to summarize our understanding of determinants and modifiable predictors of glycemic control; (2) to provide an overview of existing strategies to reduce diabetes-related disparities; and (3) to identify gaps in the literature regarding whether these interventions effectively address disparities in US Latino populations. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103872607"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103872607/Using_Enhanced_Primary_Care_Services_in_High_risk_Latino_Populations_to_Reduce_Disparities_in_Glycemic_Control"><img alt="Research paper thumbnail of Using Enhanced Primary Care Services in High-risk Latino Populations to Reduce Disparities in Glycemic Control" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103872607/Using_Enhanced_Primary_Care_Services_in_High_risk_Latino_Populations_to_Reduce_Disparities_in_Glycemic_Control">Using Enhanced Primary Care Services in High-risk Latino Populations to Reduce Disparities in Glycemic Control</a></div><div class="wp-workCard_item"><span>Journal of health care for the poor and underserved</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To determine whether enhanced primary care services delivered preferentially to high-risk patient...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To determine whether enhanced primary care services delivered preferentially to high-risk patients with diabetes (HbA1c &gt;9%) can effectively reduce racial/ethnic disparities in glycemic control. This retrospective study analyzed electronic health records to examine changes in pre-vs. post-intervention disparities in HbA1c among Hispanics/Latinos relative to non-Hispanic Whites. Mean HbA1c and prevalence of poorly controlled diabetes improved in both racial/ethnic groups, but to a greater extent among Hispanics/Latinos. Mean HbA1c dropped 0.43 points further among Hispanics/Latinos than non-Hispanic Whites (95% CI, - 0.57 to - 0.29, p&lt;.001). The change in disparity in prevalence of poorly controlled diabetes, measured as the ratio of post-vs. pre-intervention prevalence ratios, was 0.89 (95% CI, 0.84 to 0.94, p&lt;.001). Both measures indicated greater reduction among Hispanics/Latinos relative to non-Hispanic Whites. Enhanced primary care services directed at high-risk patient...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103872607"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103872607"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103872607; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=103872607]").text(description); $(".js-view-count[data-work-id=103872607]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 103872607; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='103872607']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 103872607, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=103872607]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":103872607,"title":"Using Enhanced Primary Care Services in High-risk Latino Populations to Reduce Disparities in Glycemic Control","translated_title":"","metadata":{"abstract":"To determine whether enhanced primary care services delivered preferentially to high-risk patients with diabetes (HbA1c \u0026gt;9%) can effectively reduce racial/ethnic disparities in glycemic control. 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