CINXE.COM

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class=""> <a href="/pathways/hif-enhancer-pathways" class="pathway_link" data-form="pathways_hif_enhancer_pathways"> HIF Enhancer Pathways </a> </li> <input type="hidden" name="pw_parent" value="signal-transduction"> </form> <form id="pathways_hif_repressor_pathways" action="/pathways/hif-repress-pathways" method="post"> <li class=""> <a href="/pathways/hif-repress-pathways" class="pathway_link" data-form="pathways_hif_repressor_pathways"> HIF Repressor Pathways </a> </li> <input type="hidden" name="pw_parent" value="signal-transduction"> </form> <form id="pathways_hif_stability_and_activity_pathways" action="/pathways/hif-stability-activity-pathways" method="post"> <li class=""> <a href="/pathways/hif-stability-activity-pathways" class="pathway_link" data-form="pathways_hif_stability_and_activity_pathways"> HIF Stability and Activity Pathways </a> </li> <input type="hidden" name="pw_parent" value="signal-transduction"> </form> <form id="pathways_jak_stat_signaling_pathway" action="/pathways/jak-stat-signaling-pathway" method="post"> <li class="active"> <a href="/pathways/jak-stat-signaling-pathway" class="pathway_link" data-form="pathways_jak_stat_signaling_pathway"> Jak/STAT Signaling Pathway </a> </li> <input type="hidden" name="pw_parent" value="signal-transduction"> </form> <form id="pathways_jak_stat_signaling_pathway_intracellular_regulation" action="/pathways/jak-stat-signaling-pathway-intracellular-regulation" method="post"> <li class=""> <a href="/pathways/jak-stat-signaling-pathway-intracellular-regulation" class="pathway_link" data-form="pathways_jak_stat_signaling_pathway_intracellular_regulation"> Jak/STAT Signaling Pathway Intracellular Regulation </a> </li> <input type="hidden" name="pw_parent" value="signal-transduction"> </form> <form id="pathways_mapk_signaling_pathway__mitogen_stimulation_pathway" action="/pathways/mapk-signaling-mitogen-stimulation-pathway" method="post"> <li class=""> <a href="/pathways/mapk-signaling-mitogen-stimulation-pathway" class="pathway_link" data-form="pathways_mapk_signaling_pathway__mitogen_stimulation_pathway"> MAPK Signaling Pathway: Mitogen Stimulation Pathway </a> </li> <input type="hidden" name="pw_parent" value="signal-transduction"> </form> <form id="pathways_mapk_signaling__inflammatory_cytokines_pathway" action="/pathways/mapk-signaling-inflammatory-cytokines-pathway" method="post"> <li class=""> <a href="/pathways/mapk-signaling-inflammatory-cytokines-pathway" class="pathway_link" data-form="pathways_mapk_signaling__inflammatory_cytokines_pathway"> MAPK Signaling: Inflammatory Cytokines Pathway </a> </li> <input type="hidden" name="pw_parent" value="signal-transduction"> </form> <form id="pathways_mapk_signaling__oxidative_stress_pathway" action="/pathways/mapk-oxidative-stress-pathway" method="post"> <li class=""> <a href="/pathways/mapk-oxidative-stress-pathway" class="pathway_link" data-form="pathways_mapk_signaling__oxidative_stress_pathway"> MAPK Signaling: Oxidative Stress Pathway </a> </li> <input type="hidden" name="pw_parent" value="signal-transduction"> </form> <form id="pathways_mtor_signaling_pathway" action="/pathways/mtor-signaling-pathway" method="post"> <li class=""> <a href="/pathways/mtor-signaling-pathway" class="pathway_link" data-form="pathways_mtor_signaling_pathway"> mTOR Signaling Pathway </a> </li> <input type="hidden" name="pw_parent" value="signal-transduction"> </form> <form id="pathways_notch_signaling_pathways" action="/pathways/notch-signaling-pathway" method="post"> <li class=""> <a href="/pathways/notch-signaling-pathway" class="pathway_link" data-form="pathways_notch_signaling_pathways"> Notch Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="signal-transduction"> </form> <form id="pathways_organelle_markers_pathway__ihc_icc" action="/pathways/organelle-markers-pathway-ihc-icc" method="post"> <li class=""> <a href="/pathways/organelle-markers-pathway-ihc-icc" class="pathway_link" data-form="pathways_organelle_markers_pathway__ihc_icc"> Organelle Markers Pathway: IHC/ICC </a> </li> <input type="hidden" name="pw_parent" value="signal-transduction"> </form> </ul> </li> <li class="pathways-li "> <form id="pathways_stem_cell_pathways" action="/pathways/stem-cells" method="post"> <a href="/pathways/stem-cells" data-form="pathways_stem_cell_pathways" class="pathway_link"> <span class="icon-"> Stem Cell Pathways </span> </a> <input type="hidden" name="pw_parent" value="stem-cells"> </form> </li> <li class="pathways-li "> <form id="pathways_ubiquitin_related_modifiers__pathways" action="/pathways/ubiquitin-related-modifiers-and-pathways" method="post"> <a href="/pathways/ubiquitin-related-modifiers-and-pathways" data-form="pathways_ubiquitin_related_modifiers__pathways" class="pathway_link"> <span class="icon-"> Ubiquitin, Related Modifiers, & Pathways </span> </a> <input type="hidden" name="pw_parent" value="ubiquitin-related-modifiers-and-pathways"> </form> </li> </ul> </div> </div> </div> </div> </div> <div class="pw_right col-xs-12 col-sm-8 col-md-9"> <div class="search_mobile_buttons"> <div class="pw_menu_toggle btn btn-tertiary">Show Categories</div> </div> <div class="pw_header"> <h1>Jak/STAT Signaling Pathway</h1> <p id="pw-intro-txt">Click on one of the cytokine subfamilies or receptor type to see the specific Jak and STAT molecules activated by members of the family.<br></p> <div id="pw-con" data-mapname="" data-primary_segment="jakstat_all"> <div id="pw-main-nav-wrapper"> <div class="row"> <div id="pw-button-nav-top" class="col-xs-12 col-sm-12"> <div class="row"> <div id="pw-button-nav"> <div class="dropdown col-xs-12 col-sm-6 col-md-4"> <button class="btn-pw" type="button" data-toggle="dropup">Explore Pathways<span class="caret"></span></button> <ul id="pathwaynav" class="dropdown-content"> <li data-segment="JakSTAT_TypeI-II" data-background_image="JakSTATreceptors_TypeIII.png" data-pathway_segment="Pathway_JakSTAT_TypeI-II" class="pw_rdblue_sm pw_sm_btn"><span>Type I/II Interferons</span></li> <li data-segment="JakSTAT_RTK" data-background_image="JakSTATreceptors_RTK.png" data-pathway_segment="Pathway_JakSTAT_RTK" class="pw_rdblue_sm pw_sm_btn"><span>Receptor Tyrosine Kinases</span></li> <li data-segment="JakSTAT_Homodi" data-background_image="JakSTATreceptors_Homodi.png" data-pathway_segment="Pathway_JakSTAT_Homodi" class="pw_rdblue_sm pw_sm_btn"><span>Homodimeric Hormone Receptors</span></li> <li data-segment="JakSTAT_IL6" data-background_image="JakSTATreceptors_IL6.png" data-pathway_segment="Pathway_JakSTAT_IL6" class="pw_rdblue_sm pw_sm_btn"><span>IL-6 Family</span></li> <li data-segment="JakSTAT_CommonGamma" data-background_image="JakSTATreceptors_CGC.png" data-pathway_segment="Pathway_JakSTAT_CommonGamma" class="pw_rdblue_sm pw_sm_btn"><span>Common gamma Chain Receptor Family</span></li> <li data-segment="JakSTAT_CommonBeta" data-background_image="JakSTATreceptors_CBC.png" data-pathway_segment="Pathway_JakSTAT_CommonBeta" class="pw_rdblue_sm pw_sm_btn"><span>Common beta Chain Receptor Family</span></li> <li data-segment="JakSTAT_IL12" data-background_image="JakSTATreceptors_IL12.png" data-pathway_segment="Pathway_JakSTAT_IL12" class="pw_rdblue_sm pw_sm_btn"><span>IL-12 Family</span></li> <li data-segment="JakSTAT_IL10" data-background_image="JakSTATreceptors_IL10.png" data-pathway_segment="Pathway_JakSTAT_IL10" class="pw_rdblue_sm pw_sm_btn"><span>IL-10 Family</span></li> <li data-segment="JakSTAT_GPCR" data-background_image="JakSTATreceptors_GPCR.png" data-pathway_segment="Pathway_JakSTAT_GPCR" class="pw_rdblue_sm pw_sm_btn"><span>G Protein-coupled Receptors</span></li> <li data-segment="JakSTAT_All" data-background_image="JakSTATreceptors_All.png" data-pathway_segment="JakSTAT_All" class="pw_sm_btn-active"><span>View Full Pathway</span></li> </ul> </div> </div> <div class="col-xs-12 col-sm-6 col-md-5" > <div id="pw-nav-subtitle"> Jak/STAT Signaling Pathway </div> </div> <div id="pw-print-button-col" class="col-xs-12 col-sm-6 col-md-3" > <a href="#print-copy-form" id="btn-get-print-copy" class="btn btn-primary"><img class="btn-icon" src="https://resources.rndsystems.com/images/Pathways/icons/icon-image.svg"/> Get Print Copy</a> </div> </div> </div> </div> </div> <div id="pw-map"> <div id="pw-maps"> <div id="el1_gry" class="jakstat_all jakstat_typei-ii pw-sprite el-gray1 pw-gray" style="top:66px;left:32px;"> </div> <div id="el1_off" data-id="1" data-set="IFN-alphabeta1" data-type="" class="jakstat_all jakstat_typei-ii pw-sprite el-off1" style="top:66px;left:32px;"> </div> <div id="el1_ct" class="pw-tooltip" data-id="1"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-alpha">IFN-alpha</a><br> <a target="_blank" href="/target/ifn-alpha 1">IFN-alpha 1</a><br> <a target="_blank" href="/target/ifn-alpha 11">IFN-alpha 11</a><br> <a target="_blank" href="/target/ifn-alpha 13">IFN-alpha 13</a><br> <a target="_blank" href="/target/ifn-alpha 2">IFN-alpha 2</a><br> <a target="_blank" href="/target/ifn-alpha 4">IFN-alpha 4</a><br> <a target="_blank" href="/target/ifn-alpha A">IFN-alpha A</a><br> <a target="_blank" href="/target/ifn-alpha B2">IFN-alpha B2</a><br> <a target="_blank" href="/target/ifn-alpha C">IFN-alpha C</a><br> <a target="_blank" href="/target/ifn-alpha D">IFN-alpha D</a><br> <a target="_blank" href="/target/ifn-alpha F">IFN-alpha F</a><br> <a target="_blank" href="/target/ifn-alpha G">IFN-alpha G</a><br> <a target="_blank" href="/target/ifn-alpha H2">IFN-alpha H2</a><br> <a target="_blank" href="/target/ifn-alpha I">IFN-alpha I</a><br> <a target="_blank" href="/target/ifn-alpha J1">IFN-alpha J1</a><br> <a target="_blank" href="/target/ifn-alpha K">IFN-alpha K</a><br> <a target="_blank" href="/target/ifn-alpha WA">IFN-alpha WA</a><br> <a target="_blank" href="/target/ifn-beta">IFN-beta</a><br> </div> </div> <div id="el2_gry" class="jakstat_all jakstat_typei-ii pw-label el-gray2 pw-gray" style="top:50px;left:11px;"> IFN-alpha/beta </div> <div id="el2_off" data-id="2" data-set="IFN-alphabeta1" data-type="No Products Click" class="jakstat_all jakstat_typei-ii pw-label el-off2" style="top:50px;left:11px;"> IFN-alpha/beta</div> <div id="el2_ct" class="pw-tooltip" data-id="2"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-alpha">IFN-alpha</a><br> <a target="_blank" href="/target/ifn-alpha 1">IFN-alpha 1</a><br> <a target="_blank" href="/target/ifn-alpha 11">IFN-alpha 11</a><br> <a target="_blank" href="/target/ifn-alpha 13">IFN-alpha 13</a><br> <a target="_blank" href="/target/ifn-alpha 2">IFN-alpha 2</a><br> <a target="_blank" href="/target/ifn-alpha 4">IFN-alpha 4</a><br> <a target="_blank" href="/target/ifn-alpha A">IFN-alpha A</a><br> <a target="_blank" href="/target/ifn-alpha B2">IFN-alpha B2</a><br> <a target="_blank" href="/target/ifn-alpha C">IFN-alpha C</a><br> <a target="_blank" href="/target/ifn-alpha D">IFN-alpha D</a><br> <a target="_blank" href="/target/ifn-alpha F">IFN-alpha F</a><br> <a target="_blank" href="/target/ifn-alpha G">IFN-alpha G</a><br> <a target="_blank" href="/target/ifn-alpha H2">IFN-alpha H2</a><br> <a target="_blank" href="/target/ifn-alpha I">IFN-alpha I</a><br> <a target="_blank" href="/target/ifn-alpha J1">IFN-alpha J1</a><br> <a target="_blank" href="/target/ifn-alpha K">IFN-alpha K</a><br> <a target="_blank" href="/target/ifn-alpha WA">IFN-alpha WA</a><br> <a target="_blank" href="/target/ifn-beta">IFN-beta</a><br> </div> </div> <div id="el3_gry" class="jakstat_all jakstat_typei-ii pw-sprite el-gray3 pw-gray" style="top:83px;left:23px;"> </div> <div id="el3_off" data-id="3" data-set="IFN-alphabrbetaR2" data-type="No Products Click" class="jakstat_all jakstat_typei-ii pw-sprite el-off3" style="top:83px;left:23px;"> </div> <div id="el3_ct" class="pw-tooltip" data-id="3"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-alpha-beta-r1">IFN-alpha/beta R1</a><br> <a target="_blank" href="/target/ifn-alpha-beta-r2">IFN-alpha/beta R2</a><br> </div> </div> <div id="el4_gry" class="jakstat_all jakstat_typei-ii pw-label el-gray4 pw-gray" style="top:93px;left:50px;"> IFN-alpha/<br>beta R </div> <div id="el4_off" data-id="4" data-set="IFN-alphabrbetaR2" data-type="No Products Click" class="jakstat_all jakstat_typei-ii pw-label el-off4" style="top:93px;left:50px;"> IFN-alpha/<br>beta R</div> <div id="el4_ct" class="pw-tooltip" data-id="4"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-alpha-beta-r1">IFN-alpha/beta R1</a><br> <a target="_blank" href="/target/ifn-alpha-beta-r2">IFN-alpha/beta R2</a><br> </div> </div> <div id="el5_gry" class="jakstat_all jakstat_typei-ii pw-sprite el-gray5 pw-gray" style="top:145px;left:13px;"> </div> <div id="el5_off" data-id="5" data-set="Tyk23" data-type="No Products Click" class="jakstat_all jakstat_typei-ii pw-sprite el-off5" style="top:145px;left:13px;"> </div> <div id="el5_ct" class="pw-tooltip" data-id="5"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/tyk2">Tyk2</a><br> </div> </div> <div id="el6_gry" class="jakstat_all jakstat_typei-ii pw-label el-gray6 pw-gray" style="top:163px;left:3px;"> Tyk2 </div> <div id="el6_off" data-id="6" data-set="Tyk23" data-type="No Products Click" class="jakstat_all jakstat_typei-ii pw-label el-off6" style="top:163px;left:3px;"> Tyk2</div> <div id="el6_ct" class="pw-tooltip" data-id="6"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/tyk2">Tyk2</a><br> </div> </div> <div id="el7_gry" class="jakstat_all jakstat_typei-ii pw-sprite el-gray7 pw-gray" style="top:146px;left:38px;"> </div> <div id="el7_off" data-id="7" data-set="Jak1brJak24" data-type="No Products Click" class="jakstat_all jakstat_typei-ii pw-sprite el-off7" style="top:146px;left:38px;"> </div> <div id="el7_ct" class="pw-tooltip" data-id="7"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak1">Jak1</a><br> <a target="_blank" href="/target/jak2">Jak2</a><br> <a target="_blank" href="/target/jak-kinase-inhibitors">JAK Kinase Inhibitors</a><br> </div> </div> <div id="el8_gry" class="jakstat_all jakstat_typei-ii pw-label el-gray8 pw-gray" style="top:163px;left:52px;"> Jak1<br>Jak2 </div> <div id="el8_off" data-id="8" data-set="Jak1brJak24" data-type="No Products Click" class="jakstat_all jakstat_typei-ii pw-label el-off8" style="top:163px;left:52px;"> Jak1<br>Jak2</div> <div id="el8_ct" class="pw-tooltip" data-id="8"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak1">Jak1</a><br> <a target="_blank" href="/target/jak2">Jak2</a><br> <a target="_blank" href="/target/jak-kinase-inhibitors">JAK Kinase Inhibitors</a><br> </div> </div> <div id="el9_gry" class="jakstat_all jakstat_typei-ii pw-sprite el-gray9 pw-gray" style="top:256px;left:19px;"> </div> <div id="el9_off" data-id="9" data-set="STAT1brSTAT2brSTAT3brSTAT4brSTAT5brSTAT65" data-type="No Products Click" class="jakstat_all jakstat_typei-ii pw-sprite el-off9" style="top:256px;left:19px;"> </div> <div id="el9_ct" class="pw-tooltip" data-id="9"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> <a target="_blank" href="/target/stat2">STAT2</a><br> <a target="_blank" href="/target/stat3">STAT3</a><br> <a target="_blank" href="/target/stat4">STAT4</a><br> <a target="_blank" href="/target/stat5a">STAT5a</a><br> <a target="_blank" href="/target/stat5a/b">STAT5a/b</a><br> <a target="_blank" href="/target/stat5b">STAT5b</a><br> <a target="_blank" href="/target/stat6">STAT6</a><br> <a target="_blank" href="/target/stat-activators">STAT Activators</a><br> <a target="_blank" href="/target/stat-inhibitors">STAT Inhibitors</a><br> </div> </div> <div id="el10_gry" class="jakstat_all jakstat_typei-ii pw-label el-gray10 pw-gray" style="top:275px;left:14px;"> STAT1<br>STAT2<br>STAT3<br>STAT4<br>STAT5<br>STAT6 </div> <div id="el10_off" data-id="10" data-set="STAT1brSTAT2brSTAT3brSTAT4brSTAT5brSTAT65" data-type="No Products Click" class="jakstat_all jakstat_typei-ii pw-label el-off10" style="top:275px;left:14px;"> STAT1<br>STAT2<br>STAT3<br>STAT4<br>STAT5<br>STAT6</div> <div id="el10_ct" class="pw-tooltip" data-id="10"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> <a target="_blank" href="/target/stat2">STAT2</a><br> <a target="_blank" href="/target/stat3">STAT3</a><br> <a target="_blank" href="/target/stat4">STAT4</a><br> <a target="_blank" href="/target/stat5a">STAT5a</a><br> <a target="_blank" href="/target/stat5a/b">STAT5a/b</a><br> <a target="_blank" href="/target/stat5b">STAT5b</a><br> <a target="_blank" href="/target/stat6">STAT6</a><br> <a target="_blank" href="/target/stat-activators">STAT Activators</a><br> <a target="_blank" href="/target/stat-inhibitors">STAT Inhibitors</a><br> </div> </div> <div id="el11_gry" class="jakstat_all jakstat_typei-ii pw-sprite el-gray11 pw-gray" style="top:486px;left:19px;"> </div> <div id="el11_off" data-id="11" data-set="STATbrDimer6" data-type="No Products Click" class="jakstat_all jakstat_typei-ii pw-sprite el-off11" style="top:486px;left:19px;"> </div> <div id="el11_ct" class="pw-tooltip" data-id="11"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> <a target="_blank" href="/target/stat2">STAT2</a><br> <a target="_blank" href="/target/stat3">STAT3</a><br> <a target="_blank" href="/target/stat4">STAT4</a><br> <a target="_blank" href="/target/stat5a">STAT5a</a><br> <a target="_blank" href="/target/stat5a/b">STAT5a/b</a><br> <a target="_blank" href="/target/stat5b">STAT5b</a><br> <a target="_blank" href="/target/stat6">STAT6</a><br> <a target="_blank" href="/target/stat-activators">STAT Activators</a><br> <a target="_blank" href="/target/stat-inhibitors">STAT Inhibitors</a><br> </div> </div> <div id="el12_gry" class="jakstat_all jakstat_typei-ii pw-label el-gray12 pw-gray" style="top:482px;left:55px;"> STAT<br>Dimer </div> <div id="el12_off" data-id="12" data-set="STATbrDimer6" data-type="No Products Click" class="jakstat_all jakstat_typei-ii pw-label el-off12" style="top:482px;left:55px;"> 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href="/target/stat6">STAT6</a><br> <a target="_blank" href="/target/stat-activators">STAT Activators</a><br> <a target="_blank" href="/target/stat-inhibitors">STAT Inhibitors</a><br> </div> </div> <div id="el29_off" data-id="29" data-set="STATDimer15" data-type="No Products Click" class="jakstat_typei-ii pw-sprite pw-none el-off29" style="top:825px;left:348px;"> </div> <div id="el29_ct" class="pw-tooltip" data-id="29"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> <a target="_blank" href="/target/stat2">STAT2</a><br> <a target="_blank" href="/target/stat3">STAT3</a><br> <a target="_blank" href="/target/stat5a">STAT5a</a><br> <a target="_blank" href="/target/stat5a/b">STAT5a/b</a><br> <a target="_blank" href="/target/stat5b">STAT5b</a><br> <a target="_blank" href="/target/stat6">STAT6</a><br> <a target="_blank" href="/target/stat-activators">STAT Activators</a><br> <a target="_blank" href="/target/stat-inhibitors">STAT Inhibitors</a><br> </div> </div> <div id="el30_off" data-id="30" data-set="STATDimer15" data-type="No Products Click" class="jakstat_typei-ii pw-label pw-none el-off30" style="top:820px;left:285px;"> STAT Dimer</div> <div id="el30_ct" class="pw-tooltip" data-id="30"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> <a target="_blank" href="/target/stat2">STAT2</a><br> <a target="_blank" href="/target/stat3">STAT3</a><br> <a target="_blank" href="/target/stat5a">STAT5a</a><br> <a target="_blank" href="/target/stat5a/b">STAT5a/b</a><br> <a target="_blank" href="/target/stat5b">STAT5b</a><br> <a target="_blank" href="/target/stat6">STAT6</a><br> <a target="_blank" href="/target/stat-activators">STAT Activators</a><br> <a target="_blank" href="/target/stat-inhibitors">STAT Inhibitors</a><br> </div> </div> <div id="el31_gry" class="jakstat_all jakstat_rtk pw-sprite el-gray31 pw-gray" style="top:132px;left:181px;"> </div> <div id="el31_off" data-id="31" data-set="EGF16" data-type="No Products Click" class="jakstat_all jakstat_rtk pw-sprite el-off31" style="top:132px;left:181px;"> </div> <div id="el31_ct" class="pw-tooltip" data-id="31"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/egf">EGF</a><br> </div> </div> <div id="el32_gry" class="jakstat_all jakstat_rtk pw-label el-gray32 pw-gray" style="top:121px;left:202px;"> EGF </div> <div id="el32_off" data-id="32" data-set="EGF16" data-type="No Products Click" class="jakstat_all jakstat_rtk pw-label el-off32" style="top:121px;left:202px;"> EGF</div> <div id="el32_ct" class="pw-tooltip" data-id="32"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/egf">EGF</a><br> </div> </div> <div id="el33_gry" class="jakstat_all jakstat_rtk pw-sprite el-gray33 pw-gray" style="top:153px;left:151px;"> </div> <div id="el33_off" data-id="33" data-set="EGFRbrErbB117" data-type="No Products Click" class="jakstat_all jakstat_rtk pw-sprite el-off33" style="top:153px;left:151px;"> </div> <div id="el33_ct" class="pw-tooltip" data-id="33"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/egf-r-erbb1">EGF R/ErbB1</a><br> <a target="_blank" href="/target/egf-receptor-inhibitors">EGF Receptor Inhibitors</a><br> </div> </div> <div id="el34_gry" class="jakstat_all jakstat_rtk pw-label el-gray34 pw-gray" style="top:152px;left:198px;"> EGF R/<br>ErbB1 </div> <div id="el34_off" data-id="34" data-set="EGFRbrErbB117" data-type="No Products Click" class="jakstat_all jakstat_rtk pw-label el-off34" style="top:152px;left:198px;"> EGF R/<br>ErbB1</div> <div id="el34_ct" class="pw-tooltip" data-id="34"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> 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Src </div> <div id="el36_off" data-id="36" data-set="Src18" data-type="No Products Click" class="jakstat_all jakstat_rtk pw-label el-off36" style="top:177px;left:132px;"> Src</div> <div id="el36_ct" class="pw-tooltip" data-id="36"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/src">Src</a><br> <a target="_blank" href="/target/src Family Kinase Inhibitors">Src Family Kinase Inhibitors</a><br> <a target="_blank" href="/target/src Family Kinase Ligands">Src Family Kinase Ligands</a><br> </div> </div> <div id="el37_gry" class="jakstat_all jakstat_rtk pw-sprite el-gray37 pw-gray" style="top:175px;left:146px;"> </div> <div id="el37_off" data-id="37" data-set="Jak1brJak219" data-type="No Products Click" class="jakstat_all jakstat_rtk pw-sprite el-off37" style="top:175px;left:146px;"> </div> <div id="el37_ct" class="pw-tooltip" data-id="37"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div 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href="/target/phospholipase-c-activators">Phospholipase C Activators</a><br> <a target="_blank" href="/target/phospholipase-c-inhibitors">Phospholipase C Inhibitors</a><br> </div> </div> <div id="el129_gry" class="jakstat_all jakstat_gpcr pw-sprite pw-sprite-inactive el-gray129 pw-gray" style="top:435px;left:549px;"> </div> <div id="el129_off" data-id="129" data-set="PIP265" data-type="No Products Click" class="jakstat_all jakstat_gpcr pw-sprite pw-sprite-inactive el-off129" style="top:435px;left:549px;"> </div> <div id="el129_ct" class="pw-tooltip" data-id="129"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el130_gry" class="jakstat_all jakstat_gpcr pw-label2 el-gray130 pw-gray" style="top:436px;left:531px;"> PIP<sub>2</sub> </div> <div id="el130_off" data-id="130" data-set="PIP265" data-type="" class="jakstat_all jakstat_gpcr pw-label2 el-off130" style="top:436px;left:531px;"> PIP<sub>2</sub></div> <div 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PYK2</div> <div id="el140_ct" class="pw-tooltip" data-id="140"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/pyk2-fak2">PYK2/FAK2</a><br> </div> </div> <div id="el141_gry" class="jakstat_all jakstat_gpcr pw-sprite el-gray141 pw-gray" style="top:583px;left:583px;"> </div> <div id="el141_off" data-id="141" data-set="Jak271" data-type="No Products Click" class="jakstat_all jakstat_gpcr pw-sprite el-off141" style="top:583px;left:583px;"> </div> <div id="el141_ct" class="pw-tooltip" data-id="141"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak2">Jak2</a><br> <a target="_blank" href="/target/jak-kinase-inhibitors">JAK Kinase Inhibitors</a><br> </div> </div> <div id="el142_gry" class="jakstat_all jakstat_gpcr pw-label el-gray142 pw-gray" style="top:595px;left:561px;"> Jak2 </div> <div id="el142_off" data-id="142" 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jakstat_gpcr pw-sprite el-gray147 pw-gray" style="top:593px;left:635px;"> </div> <div id="el147_off" data-id="147" data-set="STAT1brSTAT2brSTAT3brSTAT5brSTAT674" data-type="No Products Click" class="jakstat_all jakstat_gpcr pw-sprite el-off147" style="top:593px;left:635px;"> </div> <div id="el147_ct" class="pw-tooltip" data-id="147"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> <a target="_blank" href="/target/stat2">STAT2</a><br> <a target="_blank" href="/target/stat3">STAT3</a><br> <a target="_blank" href="/target/stat5a">STAT5a</a><br> <a target="_blank" href="/target/stat5a/b">STAT5a/b</a><br> <a target="_blank" href="/target/stat5b">STAT5b</a><br> <a target="_blank" href="/target/stat6">STAT6</a><br> <a target="_blank" href="/target/stat-activators">STAT Activators</a><br> <a target="_blank" href="/target/stat-inhibitors">STAT Inhibitors</a><br> </div> </div> <div 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class="jakstat_all jakstat_gpcr pw-label el-off158" style="top:492px;left:705px;"> Jak1<br>Jak2<br>Jak3<br>Tyk2</div> <div id="el158_ct" class="pw-tooltip" data-id="158"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak1">Jak1</a><br> <a target="_blank" href="/target/jak2">Jak2</a><br> <a target="_blank" href="/target/jak3">Jak3</a><br> <a target="_blank" href="/target/tyk2">Tyk2</a><br> <a target="_blank" href="/target/jak-kinase-inhibitors">JAK Kinase Inhibitors</a><br> </div> </div> <div id="el159_gry" class="jakstat_all jakstat_gpcr pw-sprite el-gray159 pw-gray" style="top:600px;left:691px;"> </div> <div id="el159_off" data-id="159" data-set="STAT1brSTAT2brSTAT3brSTAT4brSTAT580" data-type="No Products Click" class="jakstat_all jakstat_gpcr pw-sprite el-off159" style="top:600px;left:691px;"> </div> <div id="el159_ct" class="pw-tooltip" data-id="159"> <div class="pw-tooltip-head">Products<a 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STAT1<br>STAT2<br>STAT3<br>STAT4<br>STAT5</div> <div id="el160_ct" class="pw-tooltip" data-id="160"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> <a target="_blank" href="/target/stat2">STAT2</a><br> <a target="_blank" href="/target/stat3">STAT3</a><br> <a target="_blank" href="/target/stat4">STAT4</a><br> <a target="_blank" href="/target/stat5a">STAT5a</a><br> <a target="_blank" href="/target/stat5a/b">STAT5a/b</a><br> <a target="_blank" href="/target/stat5b">STAT5b</a><br> <a target="_blank" href="/target/stat-activators">STAT Activators</a><br> <a target="_blank" href="/target/stat-inhibitors">STAT Inhibitors</a><br> </div> </div> <div id="el161_off" data-id="161" data-set="STATbrDimer81" data-type="No Products Click" class="jakstat_gpcr pw-sprite pw-none el-off161" style="top:713px;left:686px;"> </div> <div id="el161_ct" class="pw-tooltip" data-id="161"> <div 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href="/target/stat5b">STAT5b</a><br> <a target="_blank" href="/target/stat6">STAT6</a><br> <a target="_blank" href="/target/stat-activators">STAT Activators</a><br> <a target="_blank" href="/target/stat-inhibitors">STAT Inhibitors</a><br> </div> </div> <div id="el166_off" data-id="166" data-set="STATDimer83" data-type="No Products Click" class="jakstat_all pw-label pw-none el-off166" style="top:822px;left:282px;"> STAT Dimer</div> <div id="el166_ct" class="pw-tooltip" data-id="166"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> <a target="_blank" href="/target/stat2">STAT2</a><br> <a target="_blank" href="/target/stat3">STAT3</a><br> <a target="_blank" href="/target/stat4">STAT4</a><br> <a target="_blank" href="/target/stat5a">STAT5a</a><br> <a target="_blank" href="/target/stat5a/b">STAT5a/b</a><br> <a target="_blank" href="/target/stat5b">STAT5b</a><br> <a target="_blank" href="/target/stat6">STAT6</a><br> <a target="_blank" href="/target/stat-activators">STAT Activators</a><br> <a target="_blank" href="/target/stat-inhibitors">STAT Inhibitors</a><br> </div> </div> <div id="el167_off" data-id="167" data-set="ISRE" data-type="" class="jakstat_typei-ii pw-label2 pw-none el-off167" style="top:830px;left:172px;"> <div class="pw_txtBox">ISRE</div></div> <div id="el167_ct" class="pw-tooltip" data-id="167"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el168_off" data-id="168" data-set="Anti-viral" data-type="" class="jakstat_typei-ii pw-label2 pw-none el-off168" style="top:908px;left:245px;"> <div class="pw_txtBox">Anti-viral</div></div> <div id="el168_ct" class="pw-tooltip" data-id="168"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el169_off" data-id="169" data-set="GAS" data-type="" class="jakstat_typei-ii pw-label2 pw-none el-off169" style="top:855px;left:354px;"> <div class="pw_txtBox">GAS</div></div> <div id="el169_ct" class="pw-tooltip" data-id="169"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el170_off" data-id="170" data-set="Type12Table" data-type="" class="jakstat_typei-ii pw-label2 pw-none el-off170" style="top:10px;left:360px;"> <TABLE class=pw_table cellSpacing=0 margin=0 width=380> <tr> <th colspan="4">Type I-II Interferons</th> </tr> <tr> <th class="rightline">Ligand</th> <th class="rightline" width=150>Receptor Complex</th> <th class="rightline" width=65>Activated Jak</th> <th width=50>Activated STAT</th> </tr> <tr> <td>IFN-alpha</td> <td>IFN-alpha-beta R1 +聽</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td>IFN-alpha-beta R2</td> <td>Jak2</td> <td>STAT2</td> </tr> <tr> <td> </td> <td> </td> <td>Tyk2</td> <td>STAT3</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT4</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT5</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT6</td> </tr> <tr> <td>IFN-beta</td> <td>IFN-alpha-beta R1 +聽</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td>IFN-alpha-beta R2</td> <td>Jak2</td> <td>STAT2</td> </tr> <tr> <td> </td> <td> </td> <td>Tyk2</td> <td>STAT3</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT4</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT5</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT6</td> </tr> <tr> <td>IFN-gamma</td> <td>IFN-gamma R1-CD119 +聽</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td>IFN-gamma R2</td> <td>Jak2</td> <td>STAT2</td> </tr> <tr> <td> </td> <td> </td> <td>Tyk2</td> <td>STAT3</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT5</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT6</td> </tr> </table></div> <div id="el170_ct" class="pw-tooltip" data-id="170"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el171_off" data-id="171" data-set="CellMigration" data-type="" class="jakstat_rtk pw-label2 pw-none el-off171" style="top:908px;left:265px;"> <div class="pw_txtBox">Cell Migration</div></div> <div id="el171_ct" class="pw-tooltip" data-id="171"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el172_off" data-id="172" data-set="RTKTable" data-type="" class="jakstat_rtk pw-label2 pw-none el-off172" style="top:10px;left:350px;"> <table class=pw_table cellspacing=0 margin=0 width="390"> <tr> <th colspan="4">Receptor Tyrosine Kinases</th> </tr> <tr> <th class="rightline">Ligand</th> <th class="rightline" width=140>Receptor Complex</th> <th class="rightline" width=70>Activated Jak</th> <th width=60>Activated STAT</th> </tr> <tr> <td>Angiopoietin-2</td> <td>Tie-2</td> <td> </td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>BDNF</td> <td>TrkB</td> <td>Jak2</td> <td>STAT1</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT3</td> </tr> <tr> <td>EGF</td> <td>EGF R/ErbB1</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td></td> <td> </td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>EGF</td> <td>ErbB2/Her2</td> <td>Jak2</td> <td>STAT1</td> </tr> <tr> <td></td> <td> </td> <td> </td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>EGF</td> <td>ErbB4/Her4</td> <td>Jak2</td> <td>STAT1</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>Ephrin-A</td> <td>EphA4</td> <td>Jak2</td> <td>STAT1</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT3</td> </tr> <tr> <td>FGF</td> <td>FGF R1</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td></td> <td>FGF R2</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td></td> <td>FGF R3</td> <td>Jak3</td> <td>STAT5</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border">FGF R4</td> <td class="pwcell_border">Tyk2</td> <td class="pwcell_border"> </td> </tr> <tr> <td>Gas6</td> <td>Mer</td> <td> </td> <td>STAT3</td> </tr> <tr> <td></td> <td> </td> <td> </td> <td>STAT5</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT6</td> </tr> <tr> <td>HGF</td> <td>HGF R/c-MET</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td></td> <td> </td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>IGF-I</td> <td>IGF-I R</td> <td>Jak1</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">Jak2</td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>M-CSF</td> <td>M-CSF R</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td></td> <td> </td> <td>Tyk2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td class="pwcell_border">PBEF/Visfatin</td> <td class="pwcell_border">Insulin R/CD220</td> <td class="pwcell_border">Jak2</td> <td class="pwcell_border">STAT3</td> </tr> <tr> <td>PDGF</td> <td>PDGF R alpha</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td></td> <td>PDGF R beta</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td></td> <td> </td> <td>Tyk2</td> <td>STAT5</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT6</td> </tr> <tr> <td>SCF/c-kit Ligand</td> <td>SCF R/c-kit</td> <td>Jak2</td> <td>STAT1</td> </tr> <tr> <td></td> <td> </td> <td> </td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>VEGF</td> <td>VEGF R1/Flt-1</td> <td>Jak2</td> <td>STAT1</td> </tr> <tr> <td></td> <td>VEGF R2/KDR/Flk-1</td> <td>Tyk2</td> <td>STAT3</td> </tr> <tr> <td></td> <td>VEGF R3/Flt-4</td> <td> </td> <td>STAT5</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT6</td> </tr> </table></div> <div id="el172_ct" class="pw-tooltip" data-id="172"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el173_off" data-id="173" data-set="Hematopoieticlt;brgtCellDifferentiationlt;brgtandProliferation" data-type="" class="jakstat_homodi pw-label2 pw-center pw-none el-off173" style="top:890px;left:220px;"> <div class="pw_txtBox">Hematopoietic Cell<br>Differentiation and Proliferation</div></div> <div id="el173_ct" class="pw-tooltip" data-id="173"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el174_off" data-id="174" data-set="HomodimericTable" data-type="" class="jakstat_homodi pw-label2 pw-none el-off174" style="top:10px;left:360px;"> <table class=pw_table cellspacing=0 margin=0 width="380"> <tr> <th colspan="4">Homodimeric Hormone Receptors</th> </tr> <tr> <th class="rightline">Ligand</th> <th class="rightline" width=150>Receptor Complex</th> <th class="rightline" width=65>Activated Jak</th> <th width=50>Activated STAT</th> </tr> <tr> <td>Erythropoietin</td> <td>Erythropoietin R</td> <td>Jak2</td> <td>STAT1</td> </tr> <tr> <td></td> <td> </td> <td>Jak3</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>Growth Hormone</td> <td>Growth Hormone R</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td></td> <td> </td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>Prolactin</td> <td>Prolactin R</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td></td> <td> </td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>Thrombopoietin/Tpo</td> <td>Thrombopoietin R/Tpo R</td> <td>Jak2</td> <td>STAT1</td> </tr> <tr> <td></td> <td> </td> <td>Tyk2</td> <td>STAT3</td> </tr> <tr> <td > </td> <td > </td> <td > </td> <td >STAT5</td> </tr> </table></div> <div id="el174_ct" class="pw-tooltip" data-id="174"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el175_off" data-id="175" data-set="ImmuneCellDifferentiationlt;brgtInflammation" data-type="" class="jakstat_il6 pw-label2 pw-center pw-none el-off175" style="top:890px;left:216px;"> <div class="pw_txtBox">Immune Cell Differentiation<br>Inflammation</div></div> <div id="el175_ct" class="pw-tooltip" data-id="175"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el176_off" data-id="176" data-set="IL6Table" data-type="" class="jakstat_il6 pw-label2 pw-none el-off176" style="top:10px;left:360px;"> <TABLE class=pw_table cellSpacing=0 margin=0 width=380> <tr> <th colspan="4">Il-6 Family</th> </tr> <tr> <th class="rightline">Ligand</th> <th class="rightline" width=115>Receptor Complex</th> <th class="rightline" width=65>Activated Jak</th> <th width=50>Activated STAT</th> </tr> <tr> <td>Cardiotrophin-1/</td> <td>CT-1 R alpha +</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td>CT-1</td> <td>LIF R alpha +</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border">gp130</td> <td class="pwcell_border">Tyk2</td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>CLF/CLC</td> <td>CNTF R alpha +</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td>LIF R alpha +</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border">gp130</td> <td class="pwcell_border">Tyk2</td> <td class="pwcell_border"> </td> </tr> <tr> <td>CNTF</td> <td>CNTF R alpha +</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td>LIF R alpha +</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border">gp130</td> <td class="pwcell_border">Tyk2</td> <td class="pwcell_border"> </td> </tr> <tr> <td>G-CSF*</td> <td>G-CSF R/</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td>CD114</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">Tyk2</td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>IL-6 </td> <td>IL-6 R alpha +</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td>gp130</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">Tyk2</td> <td class="pwcell_border"> </td> </tr> <tr> <td>IL-11</td> <td>IL-11 R alpha +</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td>gp130</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">Tyk2</td> <td class="pwcell_border"> </td> </tr> <tr> <td>IL-31</td> <td>IL-31 RA +</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td>OSM R beta</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>Leptin/OB*</td> <td>Leptin R</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td> </td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT5</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT6</td> </tr> <tr> <td>LIF</td> <td>LIF R alpha +</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td>gp130</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">Tyk2</td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>Oncostastin M/</td> <td>OSM R beta +</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td>OSM</td> <td>gp130</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td> </td> <td>LIF R alpha +</td> <td>Tyk2</td> <td>STAT5</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border">gp130</td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT6</td> </tr> <tr> <td colspan="4">*G-CSF and Leptin/OB are often associated with the IL-6 family of cytokines because the G-CSF and Leptin receptors are structurally similar to gp130.</td></tr> </table></div> <div id="el176_ct" class="pw-tooltip" data-id="176"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el177_off" data-id="177" data-set="ImmuneCellDevelopmentlt;brgtProliferationandDifferentiation" data-type="" class="jakstat_commongamma pw-label2 pw-center pw-none el-off177" style="top:890px;left:260px;"> <div class="pw_txtBox">Immune Cell Development<br>Proliferation and Differentiation</div></div> <div id="el177_ct" class="pw-tooltip" data-id="177"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el178_off" data-id="178" data-set="CGCTable" data-type="" class="jakstat_commongamma pw-label2 pw-none el-off178" style="top:10px;left:360px;"> <table class=pw_table cellspacing=0 margin=0 width="380"> <tr> <th colspan="4">Common gamma Chain Receptor Family</th> </tr> <tr> <th class="rightline" width="50">Ligand</th> <th class="rightline" width="140">Receptor Complex</th> <th class="rightline" width="60">Activated Jak</th> <th class="rightline" width="50">Activated STAT</th> </tr> <tr> <td>IL-2</td> <td>CD25/IL-2 R alpha +</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td></td> <td>IL-2 R beta +</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td></td> <td>Common gamma Chain/IL-2 R gamma</td> <td>Jak3</td> <td>STAT4</td> </tr> <tr> <td></td> <td> </td> <td> </td> <td>STAT5</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT6</td> </tr> <tr> <td>IL-4</td> <td>IL-4 R alpha + </td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td></td> <td>Common gamma Chain/IL-2 R gamma</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td></td> <td>IL-4 R alpha + </td> <td>Jak3</td> <td>STAT4</td> </tr> <tr> <td></td> <td>IL-13 R alpha 1</td> <td>Tyk2</td> <td>STAT5</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT6</td> </tr> <tr> <td>IL-7</td> <td>IL-7 R alpha/CD127 + </td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td></td> <td>Common gamma Chain/IL-2 R gamma</td> <td>Jak3</td> <td>STAT2</td> </tr> <tr> <td></td> <td> </td> <td> </td> <td>STAT3</td> </tr> <tr> <td></td> <td> </td> <td> </td> <td>STAT5</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT6</td> </tr> <tr> <td>IL-9</td> <td>IL-9 R + </td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td></td> <td>Common gamma Chain/IL-2 R gamma</td> <td>Jak3</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">Tyk2</td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>IL-13**</td> <td>IL-13 R alpha 1 + </td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td></td> <td>IL-4 R alpha</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td></td> <td> </td> <td>Jak3</td> <td>STAT5</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">Tyk2</td> <td class="pwcell_border">STAT6</td> </tr> <tr> <td>IL-15</td> <td>IL-15 R alpha + </td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td></td> <td>IL-2 R beta + </td> <td>Jak2</td> <td>STAT2</td> </tr> <tr> <td></td> <td>Common gamma Chain/IL-2 R gamma</td> <td>Jak3</td> <td>STAT3</td> </tr> <tr> <td></td> <td> </td> <td>Tyk2</td> <td>STAT4</td> </tr> <tr> <td></td> <td> </td> <td> </td> <td>STAT5</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT6</td> </tr> <tr> <td>IL-21</td> <td>IL-21 R + </td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td></td> <td>Common gamma Chain/IL-2 R gamma</td> <td>Jak3</td> <td>STAT3</td> </tr> <tr> <td></td> <td> </td> <td> </td> <td>STAT4</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>TSLP***</td> <td>IL-17 R alpha/CD127 +</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td></td> <td>TSLP R</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td colspan="4">**IL-13 is often associated with the Common gamma Chain receptor family because it binds to the same receptor complex and possesses similar biologic properties as IL-4.<br /> ***TSLP is considered to be a IL-7-related cytokine as it shares several functions and a receptor subunit with IL-7.</td> </tr> </table></div> <div id="el178_ct" class="pw-tooltip" data-id="178"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el179_off" data-id="179" data-set="HematopoieticCelllt;brgtGrowthandSurvival" data-type="" class="jakstat_commonbeta pw-label2 pw-center pw-none el-off179" style="top:890px;left:385px;"> <div class="pw_txtBox">Hematopoietic Cell<br>Growth and Survival</div></div> <div id="el179_ct" class="pw-tooltip" data-id="179"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el180_off" data-id="180" data-set="CBCTable" data-type="" class="jakstat_commonbeta pw-label2 pw-none el-off180" style="top:10px;left:360px;"> <table class=pw_table cellspacing=0 margin=0 width="380"> <tr> <th colspan="4">Common beta Chain Receptor Family</th> </tr> <tr> <th class="rightline">Ligand</th> <th class="rightline" width="150">Receptor Complex</th> <th class="rightline" width="65">Activated Jak</th> <th class="rightline" width="50">Activated STAT</th> </tr> <tr> <td>GM-CSF</td> <td>GM-CSF R alpha +</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td></td> <td>Common beta Chain</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td></td> <td> </td> <td> </td> <td>STAT5</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT6</td> </tr> <tr> <td>IL-3</td> <td>IL-3 R alpha/CD123 +</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td></td> <td>Common beta Chain</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td></td> <td> </td> <td>Tyk2</td> <td>STAT5</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT6</td> </tr> <tr> <td>IL-5</td> <td>IL-5 R alpha/CD125 +</td> <td>Jak1</td> <td>STAT3</td> </tr> <tr> <td> </td> <td>Common beta Chain</td> <td>Jak2</td> <td>STAT5</td> </tr> </table></div> <div id="el180_ct" class="pw-tooltip" data-id="180"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el181_off" data-id="181" data-set="RegulationofInflammationlt;brgtT-CellDependentImmunity" data-type="" class="jakstat_il12 pw-label2 pw-none el-off181" style="top:890px;left:384px;"> <div class="pw_txtBox">Regulation of Inflammation<br>T-Cell Dependent Immunity</div></div> <div id="el181_ct" class="pw-tooltip" data-id="181"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el182_off" data-id="182" data-set="IL12Table" data-type="" class="jakstat_il12 pw-label2 pw-none el-off182" style="top:10px;left:10px;"> <TABLE class=pw_table cellSpacing=0 margin=0 width=380> <tr> <th colspan="4">IL-12 Family</th> </tr> <tr> <th class="rightline">Ligand</th> <th class="rightline"width="180">Receptor Complex</th> <th class="rightline">Activated Jak</th> <th>Activated STAT</th> </tr> <tr> <td>IL-12</td> <td>IL-12 R beta 1 +</td> <td>Jak2</td> <td>STAT1</td> </tr> <tr> <td> </td> <td>IL-12 R beta 2</td> <td>Tyk2</td> <td>STAT3</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT4</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT5</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT6</td> </tr> <tr> <td>IL-23</td> <td>IL-12 R beta 1 +</td> <td>Jak2</td> <td>STAT1</td> </tr> <tr> <td> </td> <td>IL-23 R</td> <td>Tyk2</td> <td>STAT3</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT4</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>IL-27</td> <td>IL-27 R alpha/WSX-1/ TCCR +</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td> gp130</td> <td>Jak2</td> <td>STAT2</td> </tr> <tr> <td> </td> <td> </td> <td>Tyk2</td> <td>STAT3</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT4</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT5</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT6</td> </tr> <tr> <td>IL-35</td> <td>IL-12 R beta 2 +</td> <td> </td> <td>STAT1</td> </tr> <tr> <td> </td> <td>gp130</td> <td> </td> <td>STAT4</td> </tr> </table></div> <div id="el182_ct" class="pw-tooltip" data-id="182"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el183_off" data-id="183" data-set="ImmuneResponseslt;brgtAnti-virallt;brgtAnti-inflammation" data-type="" class="jakstat_il10 pw-label2 pw-center pw-none el-off183" style="top:890px;left:408px;"> <div class="pw_txtBox">Immune Responses<br>Anti-viral<br>Anti-inflammation</div></div> <div id="el183_ct" class="pw-tooltip" data-id="183"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el184_off" data-id="184" data-set="IL10Table" data-type="" class="jakstat_il10 pw-label2 pw-none el-off184" style="top:10px;left:10px;"> <TABLE class=pw_table cellSpacing=0 margin=0 width=400> <tr> <th colspan="4">IL-10 Family</th> </tr> <tr> <th class="rightline" width="80">Ligand</th> <th class="rightline" width="175">Receptor Complex</th> <th class="rightline">Activated Jak</th> <th>Activated STAT</th> </tr> <tr> <td>IL-10</td> <td>IL-10 R alpha +</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td>IL-10 R beta</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">Tyk2</td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>IL-19</td> <td>IL-20 R alpha +</td> <td>Jak1</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border">IL-20 R beta</td> <td class="pwcell_border">Jak2</td> <td class="pwcell_border"> </td> </tr> <tr> <td>IL-20</td> <td>IL-20 R alpha +</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td> </td> <td>IL-20 R beta</td> <td> </td> <td>STAT5</td> </tr> <tr> <td> </td> <td>IL-22 R alpha 1 +</td> <td> </td> <td> </td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> IL-20 R beta</td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> </tr> <tr> <td>IL-22</td> <td>IL-22 R alpha 1 +</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td>IL-10 R beta</td> <td>Tyk2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>IL-24</td> <td>IL-20 R alpha +</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td>IL-20 R beta</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td>IL-22 R alpha 1 +</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border">IL-20 R beta</td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT3</td> </tr> <tr> <td>IL-26/AK155</td> <td>IL-20 R alpha +</td> <td> </td> <td>STAT1</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> IL-10 R beta</td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT3</td> </tr> <tr> <td>IL-28A/IFN-</td> <td>IL-10 R beta +</td> <td>Jak2</td> <td>STAT1</td> </tr> <tr> <td>lambda 2</td> <td>IL-28 R alpha/IFN-lambda R1</td> <td> </td> <td>STAT2</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT3</td> </tr> <tr> <td>IL-28B/IFN-</td> <td>IL-10 R beta +</td> <td> </td> <td>STAT1</td> </tr> <tr> <td class="pwcell_border">lambda 3</td> <td class="pwcell_border"> IL-28 R alpha/IFN-lambda R1</td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT2</td> </tr> <tr> <td>IL-29/IFN-</td> <td>IL-10 R beta +</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td>lambda 1</td> <td>IL-28 R alpha/IFN-lambda R1</td> <td>Tyk2</td> <td>STAT2</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT3</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT4</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT5</td> </tr> </table></div> <div id="el184_ct" class="pw-tooltip" data-id="184"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el185_off" data-id="185" data-set="VascularRemodeling" data-type="" class="jakstat_gpcr pw-label2 pw-center pw-none el-off185" style="top:890px;left:390px;"> <div class="pw_txtBox">Vascular Remodeling</div></div> <div id="el185_ct" class="pw-tooltip" data-id="185"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el186_off" data-id="186" data-set="CellMigration" data-type="" class="jakstat_gpcr pw-label2 pw-none el-off186" style="top:890px;left:543px;"> <div class="pw_txtBox">Cell Migration</div></div> <div id="el186_ct" class="pw-tooltip" data-id="186"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el187_off" data-id="187" data-set="GPCRTable" data-type="" class="jakstat_gpcr pw-label2 pw-none el-off187" style="top:10px;left:10px;"> <TABLE class=pw_table cellSpacing=0 margin=0 width=400> <tr> <th colspan="4">G Protein-Coupled Receptors</th> </tr> <tr> <th class="rightline">Ligand</th> <th class="rightline">Receptor Complex</th> <th class="rightline" width=60>Activated Jak</th> <th width=50>Activated STAT</th> </tr> <tr> <td>Angiotensin II</td> <td>AGTR-1</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td> </td> <td>Jak2</td> <td>STAT2</td> </tr> <tr> <td> </td> <td> </td> <td>Tyk2</td> <td>STAT3</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT5</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT6</td> </tr> <tr> <td>Bradykinin</td> <td>Bradykinin RB2/</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border">BDKRB2</td> <td class="pwcell_border">Tyk2</td> <td class="pwcell_border"> </td> </tr> <tr> <td>Catecholamines</td> <td>alpha-1A Adrenergic R/</td> <td>Jak2</td> <td>STAT1</td> </tr> <tr> <td> </td> <td>ADRA1A</td> <td>Tyk2</td> <td>STAT3</td> </tr> <tr> <td> </td> <td>alpha-1B Adrenergic R/</td> <td> </td> <td> </td> </tr> <tr> <td> </td> <td>ADRA1B</td> <td> </td> <td> </td> </tr> <tr> <td> </td> <td>alpha-1D Adrenergic R/</td> <td> </td> <td> </td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border">ADRA1D</td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> </tr> <tr> <td>CCL2/JE/MCP-1</td> <td>CCR2</td> <td>Jak2</td> <td>STAT1</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>CCL15/MIP-1 delta</td> <td>CCR1</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT3</td> </tr> <tr> <td>Coagulation Factor II/</td> <td>PAR1</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td>Thrombin</td> <td>PAR3</td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border">PAR4</td> <td class="pwcell_border">Tyk2</td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>CXCL12/SDF-1</td> <td>CXCR4</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td> </td> <td>Jak2</td> <td>STAT2</td> </tr> <tr> <td> </td> <td> </td> <td>Jak3</td> <td>STAT3</td> </tr> <tr> <td> </td> <td> </td> <td>Tyk2</td> <td>STAT4</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>Platelet-activating</td> <td>PAFR</td> <td>Jak2</td> <td>STAT1</td> </tr> <tr> <td>Factor (PAF)</td> <td> </td> <td>Tyk2</td> <td>STAT2</td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>RANTES/CCL5</td> <td>CCR5</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td> </td> <td> </td> <td>Jak2</td> <td>STAT3</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">Jak3</td> <td class="pwcell_border">STAT5</td> </tr> <tr> <td>Serotonin (5-HT)</td> <td>5-HT2A</td> <td>Jak1</td> <td>STAT1</td> </tr> <tr> <td class="pwcell_border"> </td> <td class="pwcell_border"> </td> <td class="pwcell_border">Jak2</td> <td class="pwcell_border">STAT3</td> </tr> </table></div> <div id="el187_ct" class="pw-tooltip" data-id="187"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> </div> <div id="pw-img"> <img id="cont-img" src="https://resources.rndsystems.com/images/Pathways/pathway-images/jakstatreceptors_all.png" alt="Jak/STAT Signaling Pathway" style="height:975px"> </div> </div> <div id="pathway-description"><h2>Overview of Jak/STAT Signaling Pathway</h2><p><p>The Jak/STAT pathway is a putative intracellular signaling pathway that mediates the effects of a large number of cytokines and growth factors. These compounds generally bind to receptors that lack intrinsic kinase activity and thus utilize intracellular enzymes to initiate downstream signaling. This signaling pathway is relatively straightforward as it includes only two main components: Janus Kinases (Jaks) and Signal Transducers and Activators of Transcription (STATs). Jak proteins are non-receptor tyrosine kinases that are constitutively associated with the cytoplasmic domain of receptors. The Jak family includes Jak1, Jak2, Jak3, and Tyk2 (Tyrosine Kinase 2). STAT proteins are latent transcription factors that reside in the cytoplasm until activated via phosphorylation, at which time they translocate to the nucleus. Seven STAT family members have thus far been identified: STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6.</p> <p>The Jak/STAT pathway is activated following binding of a cytokine or growth factor to its respective receptor. Receptor engagement by a ligand initiates oligomerization of the receptor chains allowing the associated Jak proteins to activate each other by reciprocal tyrosine phosphorylation. The activated Jaks subsequently phosphorylate specific tyrosine residues in the intracellular domains of the receptor. These phosphorylated residues serve as docking sites for the Src homology 2 (SH2)-domain of STAT proteins. Once bound to the receptor, STAT proteins are phosphorylated by Jaks or other kinases, such as Src. Phosphorylated STATs dissociate from the receptor, dimerize, and then translocate to the nucleus where they complex with other nuclear proteins and bind to specific sequences to regulate the expression of target genes.<p> <p>To date, over 50 cytokines and growth factors have been shown to utilize the four Jak proteins and seven STAT molecules to regulate cell growth, survival differentiation, motility, and immune responses. Activators of the Jak/STAT signaling pathway include type I/II Interferons, the IL-6, IL-10, IL-12, Common gamma Chain, and Common beta Chain families of cytokines, and numerous growth factors that signal through homodimeric hormone receptors, receptor tyrosine kinases, and G protein-coupled receptors. These receptors activate the same general Jak/STAT pathway, though several notable differences occur. STAT1 and STAT2 activated by type I Interferons associate with Interferon Regulatory Factor 9 (IRF9), also called ISGF3-gamma, to form an Interferon-Stimulated Gene Factor-3 (ISGF3) complex. This complex translocates to the nucleus and binds to the interferon-sensitive response element (ISRE). Additionally, Angiotensin II activates the Jak/STAT pathway by two mechanisms. It stimulates the association of Jak proteins, followed by their subsequent phosphorylation, to the Angiotensin II Receptor, Type 1 (AGTR-1) via the tyrosine phosphatase SHP-2. Angiotensin II also stimulates Jak phosphorylation by Proline-rich Tyrosine Kinase 2 (PYK2) via the PLC-IP3-Ca<sup>2+</sup>- and PLC-DAG-PKC-delta-mediated pathways.<p> <p>This interactive pathway illustrates a comprehensive list of all Jak and STAT proteins reported to be activated by the different receptor families. It is generally accepted that receptors preferably signal through specific Jak and STAT proteins. However, several factors, such as expression profiles of Jak and STAT proteins, the presence of regulatory molecules, and crosstalk from other signaling pathways, can influence which Jak and STAT proteins are activated by a receptor. To view the references for this information, please visit our <a href="/resources/articles/reference-guide-jak-stat-signaling">Jak/STAT reference table</a>.<p> <p>To learn more, please visit our <a href="/research-area/jak-stat-signaling">Jak/STAT Signaling Research Area</a>.</p> </p></div> <div id="print-copy-form" class="accordion-wrapper"> <h3 class="builder-header builder-bead-type ui-accordion-header ui-helper-reset ui-state-default ui-corner-all ui-accordion-icons" data-toggle="collapse" data-target="#collapsePathwayRequest" aria-expanded="false" id="pathwayRequestAccordionHeader"> <span class="ui-accordion-header-icon" id="accordionArrow"></span> Get Print Copy of this Pathway </h3> <div class="collapse" id="collapsePathwayRequest"> <div id="pathwayRequestWebformWrapper"> <form class="webform-client-form webform-client-form-27981" action="/pathways/jak-stat-signaling-pathway" method="post" id="webform-client-form-27981" accept-charset="UTF-8"><div><div class="form-item 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