CINXE.COM

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col-sm-8 col-md-9"> <div class="search_mobile_buttons"> <div class="pw_menu_toggle btn btn-tertiary">Show Categories</div> </div> <div class="pw_header"> <h1>HIF Stability and Activity Pathways</h1> <p id="pw-intro-txt">Click on one of the choices in the Explore Pathways box to see how HIF transcription factors are regulated during normoxia versus hypoxia and mechanisms by which HIF repressors and HIF enhancers modulate the activity of HIF transcription factors.<br /> <br /> <br></p> <div id="pw-con" data-mapname="" data-primary_segment="hif_all"> <div id="pw-main-nav-wrapper"> <div class="row"> <div id="pw-button-nav-top" class="col-xs-12 col-sm-12"> <div class="row"> <div id="pw-button-nav"> <div class="dropdown col-xs-12 col-sm-6 col-md-4"> <button class="btn-pw" type="button" data-toggle="dropup">Explore Pathways<span class="caret"></span></button> <ul id="pathwaynav" class="dropdown-content"><li data-segment="HIF_Normoxia" data-background_image="HIF_Normoxia.png" data-pathway_segment="Pathway_HIF_Normoxia" class="pw_rdblue_sm pw_sm_btn"><span>Normoxia</span></li> <li data-segment="HIF_Hypoxia" data-background_image="HIF_Hypoxia.png" data-pathway_segment="Pathway_HIF_Hypoxia" class="pw_rdblue_sm pw_sm_btn"><span>Hypoxia</span></li> <li data-title="Pathway_HIF_Repressors" class="pw-blu-btn pw-arrow-l-50-btn"><a href="/pathways/hif-repress-pathways" ><span>Repressors</span></a></li><li data-title="Pathway_HIF_Enhancers" class="pw-blu-btn pw-arrow-r-50-btn"><a href="/pathways/hif-enhancer-pathways" ><span>Enhancers</span></a></li> <li data-segment="HIF_All" data-background_image="HIF_All.png" data-pathway_segment="Pathway_HIF_All" class="pw_sm_btn-active"><span>View聽Full聽Pathway</span></li> </ul> </div> </div> <div class="col-xs-12 col-sm-6 col-md-5" > <div id="pw-nav-subtitle"> HIF Stability and Activity Pathways </div> </div> <div id="pw-print-button-col" class="col-xs-12 col-sm-6 col-md-3" > <a href="#print-copy-form" id="btn-get-print-copy" class="btn btn-primary"><img class="btn-icon" src="https://resources.rndsystems.com/images/Pathways/icons/icon-image.svg"/> Get Print Copy</a> </div> </div> </div> </div> </div> <div id="pw-map"> <div id="pw-maps"> <div id="el1_gry" class="hif_all hif_normoxia pw-sprite el-gray1 pw-gray" style="top:163px;left:99px;"> </div> <div id="el1_off" data-id="1" data-set="PHD1" data-type="" class="hif_all hif_normoxia pw-sprite el-off1" style="top:163px;left:99px;"> </div> <div id="el1_ct" class="pw-tooltip" data-id="1"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/egln2-phd1">EGLN2/PHD1</a><br> <a target="_blank" href="/target/egln3-phd3">EGLN3/PHD3</a><br> <a target="_blank" href="/target/egln1-phd2">EGLN1/PHD2</a><br> </div> </div> <div id="el2_gry" class="hif_all hif_normoxia pw-label el-gray2 pw-gray" style="top:171px;left:76px;"> PHD </div> <div id="el2_off" data-id="2" data-set="PHD1" data-type="No Products Click" class="hif_all hif_normoxia pw-label el-off2" style="top:171px;left:76px;"> PHD</div> <div id="el2_ct" class="pw-tooltip" data-id="2"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/egln2-phd1">EGLN2/PHD1</a><br> <a target="_blank" href="/target/egln3-phd3">EGLN3/PHD3</a><br> <a target="_blank" href="/target/egln1-phd2">EGLN1/PHD2</a><br> </div> </div> <div id="el3_gry" class="hif_all hif_normoxia pw-sprite el-gray3 pw-gray" style="top:216px;left:134px;"> </div> <div id="el3_off" data-id="3" data-set="HIF-12alpha2" data-type="No Products Click" class="hif_all hif_normoxia pw-sprite el-off3" style="top:216px;left:134px;"> </div> <div id="el3_ct" class="pw-tooltip" data-id="3"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-1-alpha">HIF-1 alpha</a><br> <a target="_blank" href="/target/hif-2-alpha-epas1">HIF-2 alpha/EPAS1</a><br> </div> </div> <div id="el4_gry" class="hif_all hif_normoxia pw-label el-gray4 pw-gray" style="top:222px;left:62px;"> HIF-1/2 alpha </div> <div id="el4_off" data-id="4" data-set="HIF-12alpha2" data-type="No Products Click" class="hif_all hif_normoxia pw-label el-off4" style="top:222px;left:62px;"> HIF-1/2 alpha</div> <div id="el4_ct" class="pw-tooltip" data-id="4"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-1-alpha">HIF-1 alpha</a><br> <a target="_blank" href="/target/hif-2-alpha-epas1">HIF-2 alpha/EPAS1</a><br> </div> </div> <div id="el5_gry" class="hif_all hif_normoxia pw-sprite el-gray5 pw-gray" style="top:191px;left:237px;"> </div> <div id="el5_off" data-id="5" data-set="pVHL3" data-type="No Products Click" class="hif_all hif_normoxia pw-sprite el-off5" style="top:191px;left:237px;"> </div> <div id="el5_ct" class="pw-tooltip" data-id="5"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=pVHL">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el6_gry" class="hif_all hif_normoxia pw-label el-gray6 pw-gray" style="top:198px;left:209px;"> pVHL </div> <div id="el6_off" data-id="6" data-set="pVHL3" data-type="No Products Click" class="hif_all hif_normoxia pw-label el-off6" style="top:198px;left:209px;"> pVHL</div> <div id="el6_ct" class="pw-tooltip" data-id="6"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=pVHL">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el7_gry" class="hif_all hif_normoxia pw-sprite el-gray7 pw-gray" style="top:216px;left:239px;"> </div> <div id="el7_off" data-id="7" data-set="HIF-12alpha4" data-type="No Products Click" class="hif_all hif_normoxia pw-sprite el-off7" style="top:216px;left:239px;"> </div> <div id="el7_ct" class="pw-tooltip" data-id="7"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-1-alpha">HIF-1 alpha</a><br> <a target="_blank" href="/target/hif-2-alpha-epas1">HIF-2 alpha/EPAS1</a><br> <a target="_blank" href="/target/ubiquitin">Ubiquitin</a><br> </div> </div> <div id="el8_gry" class="hif_all hif_normoxia pw-label el-gray8 pw-gray" style="top:243px;left:248px;"> HIF-1/2 alpha </div> <div id="el8_off" data-id="8" data-set="HIF-12alpha4" data-type="No Products Click" class="hif_all hif_normoxia pw-label el-off8" style="top:243px;left:248px;"> HIF-1/2 alpha</div> <div 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class="hif_all hif_normoxia hif_hypoxia pw-label el-gray10 pw-gray" style="top:287px;left:100px;"> HIF-1/2 alpha </div> <div id="el10_off" data-id="10" data-set="HIF-12alpha5" data-type="No Products Click" class="hif_all hif_normoxia hif_hypoxia pw-label el-off10" style="top:287px;left:100px;"> HIF-1/2 alpha</div> <div id="el10_ct" class="pw-tooltip" data-id="10"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-1-alpha">HIF-1 alpha</a><br> <a target="_blank" href="/target/hif-2-alpha-epas1">HIF-2 alpha/EPAS1</a><br> </div> </div> <div id="el11_gry" class="hif_all hif_normoxia hif_hypoxia pw-sprite el-gray11 pw-gray" style="top:194px;left:353px;"> </div> <div id="el11_off" data-id="11" data-set="Proteasome6" data-type="No Products Click" class="hif_all hif_normoxia hif_hypoxia pw-sprite el-off11" style="top:194px;left:353px;"> </div> <div id="el11_ct" class="pw-tooltip" data-id="11"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/26s-proteasome">26S Proteasome</a><br> <a target="_blank" href="/target/19s-proteasome">19S Proteasome</a><br> <a target="_blank" href="/target/20s-proteasome">20S Proteasome</a><br> </div> </div> <div id="el12_gry" class="hif_all hif_normoxia hif_hypoxia pw-label el-gray12 pw-gray" style="top:232px;left:348px;"> 26S Proteasome </div> <div id="el12_off" data-id="12" data-set="Proteasome6" data-type="No Products Click" class="hif_all hif_normoxia hif_hypoxia pw-label el-off12" style="top:232px;left:348px;"> 26S Proteasome</div> <div id="el12_ct" class="pw-tooltip" data-id="12"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/26s-proteasome">26S Proteasome</a><br> <a target="_blank" href="/target/19s-proteasome">19S Proteasome</a><br> <a target="_blank" href="/target/20s-proteasome">20S Proteasome</a><br> </div> </div> <div id="el13_gry" class="hif_all hif_normoxia hif_hypoxia pw-sprite el-gray13 pw-gray" style="top:116px;left:346px;"> </div> <div id="el13_off" data-id="13" data-set="USP287" data-type="No Products Click" class="hif_all hif_normoxia hif_hypoxia pw-sprite el-off13" style="top:116px;left:346px;"> </div> <div id="el13_ct" class="pw-tooltip" data-id="13"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/usp28">USP28</a><br> </div> </div> <div id="el14_gry" class="hif_all hif_normoxia hif_hypoxia pw-label el-gray14 pw-gray" style="top:124px;left:310px;"> USP28 </div> <div id="el14_off" data-id="14" data-set="USP287" data-type="No Products Click" class="hif_all hif_normoxia hif_hypoxia pw-label el-off14" style="top:124px;left:310px;"> USP28</div> <div id="el14_ct" class="pw-tooltip" data-id="14"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/usp28">USP28</a><br> </div> </div> <div id="el15_gry" class="hif_all hif_normoxia hif_hypoxia pw-sprite el-gray15 pw-gray" style="top:116px;left:417px;"> </div> <div id="el15_off" data-id="15" data-set="HIF-1alpha8" data-type="No Products Click" class="hif_all hif_normoxia hif_hypoxia pw-sprite el-off15" style="top:116px;left:417px;"> </div> <div id="el15_ct" class="pw-tooltip" data-id="15"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-1-alpha">HIF-1 alpha</a><br> <a target="_blank" href="/target/ubiquitin">Ubiquitin</a><br> </div> </div> <div id="el16_gry" class="hif_all hif_normoxia hif_hypoxia pw-label el-gray16 pw-gray" style="top:144px;left:414px;"> HIF-1 alpha </div> <div id="el16_off" data-id="16" data-set="HIF-1alpha8" data-type="No Products Click" class="hif_all hif_normoxia hif_hypoxia pw-label el-off16" style="top:144px;left:414px;"> HIF-1 alpha</div> <div id="el16_ct" class="pw-tooltip" data-id="16"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-1-alpha">HIF-1 alpha</a><br> <a target="_blank" href="/target/ubiquitin">Ubiquitin</a><br> </div> </div> <div id="el17_gry" class="hif_all hif_normoxia hif_hypoxia pw-sprite el-gray17 pw-gray" style="top:97px;left:437px;"> </div> <div id="el17_off" data-id="17" data-set="FBXW79" data-type="No Products Click" class="hif_all hif_normoxia hif_hypoxia pw-sprite el-off17" style="top:97px;left:437px;"> </div> <div id="el17_ct" class="pw-tooltip" data-id="17"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/fbxw7-cdc4">FBXW7/Cdc4</a><br> </div> </div> <div id="el18_gry" class="hif_all hif_normoxia hif_hypoxia pw-label el-gray18 pw-gray" style="top:86px;left:447px;"> FBXW7 </div> <div id="el18_off" data-id="18" data-set="FBXW79" data-type="No Products Click" class="hif_all hif_normoxia hif_hypoxia pw-label el-off18" style="top:86px;left:447px;"> FBXW7</div> <div id="el18_ct" class="pw-tooltip" data-id="18"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/fbxw7-cdc4">FBXW7/Cdc4</a><br> </div> </div> <div id="el19_gry" class="hif_all hif_normoxia hif_hypoxia pw-sprite el-gray19 pw-gray" style="top:101px;left:501px;"> </div> <div id="el19_off" data-id="19" data-set="HIF-1alpha10" data-type="No Products Click" class="hif_all hif_normoxia hif_hypoxia pw-sprite el-off19" style="top:101px;left:501px;"> </div> <div id="el19_ct" class="pw-tooltip" data-id="19"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-1-alpha">HIF-1 alpha</a><br> </div> </div> <div id="el20_gry" class="hif_all hif_normoxia hif_hypoxia pw-label el-gray20 pw-gray" style="top:110px;left:533px;"> HIF-1 alpha </div> <div id="el20_off" data-id="20" data-set="HIF-1alpha10" data-type="No Products Click" class="hif_all hif_normoxia hif_hypoxia pw-label el-off20" style="top:110px;left:533px;"> HIF-1 alpha</div> <div id="el20_ct" class="pw-tooltip" data-id="20"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-1-alpha">HIF-1 alpha</a><br> </div> </div> <div id="el21_gry" class="hif_all hif_normoxia hif_hypoxia pw-sprite el-gray21 pw-gray" style="top:77px;left:558px;"> </div> <div id="el21_off" data-id="21" data-set="GSK-3beta11" data-type="No Products Click" class="hif_all hif_normoxia hif_hypoxia pw-sprite el-off21" style="top:77px;left:558px;"> </div> <div id="el21_ct" class="pw-tooltip" data-id="21"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/gsk-3-beta">GSK-3 beta</a><br> </div> </div> <div id="el22_gry" class="hif_all hif_normoxia hif_hypoxia pw-label el-gray22 pw-gray" style="top:86px;left:590px;"> GSK-3 beta </div> <div id="el22_off" data-id="22" data-set="GSK-3beta11" data-type="No Products Click" class="hif_all hif_normoxia hif_hypoxia pw-label el-off22" style="top:86px;left:590px;"> GSK-3 beta</div> <div id="el22_ct" class="pw-tooltip" data-id="22"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/gsk-3-beta">GSK-3 beta</a><br> </div> </div> <div id="el23_gry" class="hif_all hif_normoxia hif_hypoxia pw-sprite el-gray23 pw-gray" style="top:146px;left:531px;"> </div> <div id="el23_off" data-id="23" data-set="SART1HAF12" data-type="No Products Click" class="hif_all hif_normoxia hif_hypoxia pw-sprite el-off23" style="top:146px;left:531px;"> </div> <div id="el23_ct" class="pw-tooltip" data-id="23"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/sart1">SART1</a><br> </div> </div> <div id="el24_gry" class="hif_all hif_normoxia hif_hypoxia pw-label el-gray24 pw-gray" style="top:155px;left:562px;"> SART1/HAF </div> <div id="el24_off" data-id="24" data-set="SART1HAF12" data-type="No Products Click" class="hif_all hif_normoxia hif_hypoxia pw-label el-off24" style="top:155px;left:562px;"> SART1/HAF</div> <div id="el24_ct" class="pw-tooltip" data-id="24"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/sart1">SART1</a><br> </div> </div> <div id="el25_gry" class="hif_all hif_normoxia hif_hypoxia pw-sprite el-gray25 pw-gray" style="top:203px;left:503px;"> </div> <div id="el25_off" data-id="25" data-set="HIF-1alpha13" data-type="No Products Click" class="hif_all hif_normoxia hif_hypoxia pw-sprite el-off25" style="top:203px;left:503px;"> </div> <div id="el25_ct" class="pw-tooltip" data-id="25"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-1-alpha">HIF-1 alpha</a><br> <a target="_blank" href="/target/ubiquitin">Ubiquitin</a><br> </div> </div> <div id="el26_gry" class="hif_all hif_normoxia hif_hypoxia pw-label el-gray26 pw-gray" style="top:212px;left:535px;"> HIF-1 alpha </div> <div id="el26_off" data-id="26" data-set="HIF-1alpha13" data-type="No Products Click" class="hif_all hif_normoxia hif_hypoxia pw-label el-off26" style="top:212px;left:535px;"> HIF-1 alpha</div> <div id="el26_ct" class="pw-tooltip" data-id="26"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-1-alpha">HIF-1 alpha</a><br> <a target="_blank" href="/target/ubiquitin">Ubiquitin</a><br> </div> </div> <div id="el27_gry" class="hif_all hif_hypoxia pw-sprite el-gray27 pw-gray" style="top:176px;left:595px;"> </div> <div id="el27_off" data-id="27" data-set="CHIP14" data-type="No Products Click" class="hif_all hif_hypoxia pw-sprite el-off27" style="top:176px;left:595px;"> </div> <div id="el27_ct" class="pw-tooltip" data-id="27"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/chip-stub1">CHIP/STUB1</a><br> </div> </div> <div id="el28_gry" class="hif_all hif_hypoxia pw-label el-gray28 pw-gray" style="top:184px;left:626px;"> CHIP </div> <div id="el28_off" data-id="28" data-set="CHIP14" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off28" style="top:184px;left:626px;"> CHIP</div> <div id="el28_ct" class="pw-tooltip" data-id="28"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/chip-stub1">CHIP/STUB1</a><br> </div> </div> <div id="el29_gry" class="hif_all hif_hypoxia pw-sprite el-gray29 pw-gray" style="top:196px;left:602px;"> </div> <div id="el29_off" data-id="29" data-set="HSP7015" data-type="No Products Click" class="hif_all hif_hypoxia pw-sprite el-off29" style="top:196px;left:602px;"> </div> <div id="el29_ct" class="pw-tooltip" data-id="29"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hsp70-hspa1a">HSP70/HSPA1A</a><br> </div> </div> <div id="el30_gry" class="hif_all hif_hypoxia pw-label el-gray30 pw-gray" style="top:205px;left:634px;"> HSP70 </div> <div id="el30_off" data-id="30" data-set="HSP7015" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off30" style="top:205px;left:634px;"> HSP70</div> <div id="el30_ct" class="pw-tooltip" data-id="30"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hsp70-hspa1a">HSP70/HSPA1A</a><br> </div> </div> <div id="el31_gry" class="hif_all hif_hypoxia pw-sprite el-gray31 pw-gray" style="top:290px;left:460px;"> </div> <div id="el31_off" data-id="31" data-set="HIF-2alpha16" data-type="No Products Click" class="hif_all hif_hypoxia pw-sprite el-off31" style="top:290px;left:460px;"> </div> <div id="el31_ct" class="pw-tooltip" data-id="31"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-2-alpha-epas1">HIF-2 alpha/EPAS1</a><br> <a target="_blank" href="/target/ubiquitin">Ubiquitin</a><br> <a target="_blank" href="/target/sumo">SUMO</a><br> <a target="_blank" href="/target/sumo1">SUMO1</a><br> <a target="_blank" href="/target/sumo1/2/3">SUMO1/2/3</a><br> <a target="_blank" href="/target/sumo2/3/4">SUMO2/3/4</a><br> <a target="_blank" href="/target/sumo3">SUMO3</a><br> <a target="_blank" href="/target/sumo4">SUMO4</a><br> </div> </div> <div id="el32_gry" class="hif_all hif_hypoxia pw-label el-gray32 pw-gray" style="top:284px;left:488px;"> HIF-2 alpha </div> <div id="el32_off" data-id="32" data-set="HIF-2alpha16" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off32" style="top:284px;left:488px;"> HIF-2 alpha</div> <div id="el32_ct" class="pw-tooltip" data-id="32"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-2-alpha-epas1">HIF-2 alpha/EPAS1</a><br> <a target="_blank" href="/target/ubiquitin">Ubiquitin</a><br> <a target="_blank" href="/target/sumo">SUMO</a><br> <a target="_blank" href="/target/sumo1">SUMO1</a><br> <a target="_blank" href="/target/sumo1/2/3">SUMO1/2/3</a><br> <a target="_blank" href="/target/sumo2/3/4">SUMO2/3/4</a><br> <a target="_blank" href="/target/sumo3">SUMO3</a><br> <a target="_blank" href="/target/sumo4">SUMO4</a><br> </div> </div> <div id="el33_gry" class="hif_all hif_hypoxia pw-sprite el-gray33 pw-gray" style="top:301px;left:512px;"> </div> <div id="el33_off" data-id="33" data-set="Ubc917" data-type="No Products Click" class="hif_all hif_hypoxia pw-sprite el-off33" style="top:301px;left:512px;"> </div> <div id="el33_ct" class="pw-tooltip" data-id="33"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ube2i-ubc9">UBE2I/Ubc9</a><br> </div> </div> <div id="el34_gry" class="hif_all hif_hypoxia pw-label el-gray34 pw-gray" style="top:309px;left:544px;"> Ubc9 </div> <div id="el34_off" data-id="34" data-set="Ubc917" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off34" style="top:309px;left:544px;"> Ubc9</div> <div id="el34_ct" class="pw-tooltip" data-id="34"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ube2i-ubc9">UBE2I/Ubc9</a><br> </div> </div> <div id="el35_gry" class="hif_all hif_hypoxia pw-sprite el-gray35 pw-gray" style="top:334px;left:510px;"> </div> <div id="el35_off" data-id="35" data-set="SENP118" data-type="No Products Click" class="hif_all hif_hypoxia pw-sprite el-off35" style="top:334px;left:510px;"> </div> <div id="el35_ct" class="pw-tooltip" data-id="35"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/senp1">SENP1</a><br> </div> </div> <div id="el36_gry" class="hif_all hif_hypoxia pw-label el-gray36 pw-gray" style="top:343px;left:541px;"> SENP1 </div> <div id="el36_off" data-id="36" data-set="SENP118" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off36" style="top:343px;left:541px;"> SENP1</div> <div id="el36_ct" class="pw-tooltip" data-id="36"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/senp1">SENP1</a><br> </div> </div> <div id="el37_gry" class="hif_all hif_hypoxia pw-sprite el-gray37 pw-gray" style="top:318px;left:459px;"> </div> <div id="el37_off" data-id="37" data-set="RNF4pVHL19" data-type="No Products Click" class="hif_all hif_hypoxia pw-sprite el-off37" style="top:318px;left:459px;"> </div> <div id="el37_ct" class="pw-tooltip" data-id="37"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/rnf4">RNF4</a><br> </div> </div> <div id="el38_gry" class="hif_all hif_hypoxia pw-label el-gray38 pw-gray" style="top:333px;left:398px;"> RNF4/pVHL </div> <div id="el38_off" data-id="38" data-set="RNF4pVHL19" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off38" style="top:333px;left:398px;"> RNF4/pVHL</div> <div id="el38_ct" class="pw-tooltip" data-id="38"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/rnf4">RNF4</a><br> </div> </div> <div id="el39_gry" class="hif_all hif_hypoxia pw-sprite el-gray39 pw-gray" style="top:440px;left:229px;"> </div> <div id="el39_off" data-id="39" data-set="HIF-12alpha20" data-type="No Products Click" class="hif_all hif_hypoxia pw-sprite el-off39" style="top:440px;left:229px;"> </div> <div id="el39_ct" class="pw-tooltip" data-id="39"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-1-alpha">HIF-1 alpha</a><br> <a target="_blank" href="/target/hif-2-alpha-epas1">HIF-2 alpha/EPAS1</a><br> </div> </div> <div id="el40_gry" class="hif_all hif_hypoxia pw-label el-gray40 pw-gray" style="top:461px;left:257px;"> HIF-1/2 alpha </div> <div id="el40_off" data-id="40" data-set="HIF-12alpha20" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off40" style="top:461px;left:257px;"> HIF-1/2 alpha</div> <div id="el40_ct" class="pw-tooltip" data-id="40"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-1-alpha">HIF-1 alpha</a><br> <a target="_blank" href="/target/hif-2-alpha-epas1">HIF-2 alpha/EPAS1</a><br> </div> </div> <div id="el41_gry" class="hif_all hif_hypoxia pw-sprite el-gray41 pw-gray" style="top:501px;left:438px;"> </div> <div id="el41_off" data-id="41" data-set="HIF-12alpha21" data-type="No Products Click" class="hif_all hif_hypoxia pw-sprite el-off41" style="top:501px;left:438px;"> </div> <div id="el41_ct" class="pw-tooltip" data-id="41"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-1-alpha">HIF-1 alpha</a><br> <a target="_blank" href="/target/hif-2-alpha-epas1">HIF-2 alpha/EPAS1</a><br> </div> </div> <div id="el42_gry" class="hif_all hif_hypoxia pw-label el-gray42 pw-gray" style="top:485px;left:368px;"> HIF-1/2 alpha </div> <div id="el42_off" data-id="42" data-set="HIF-12alpha21" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off42" style="top:485px;left:368px;"> HIF-1/2 alpha</div> <div id="el42_ct" class="pw-tooltip" data-id="42"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-1-alpha">HIF-1 alpha</a><br> <a target="_blank" href="/target/hif-2-alpha-epas1">HIF-2 alpha/EPAS1</a><br> </div> </div> <div id="el43_gry" class="hif_all hif_hypoxia pw-sprite el-gray43 pw-gray" style="top:483px;left:447px;"> </div> <div id="el43_off" data-id="43" data-set="p300CBP22" data-type="No Products Click" class="hif_all hif_hypoxia pw-sprite el-off43" style="top:483px;left:447px;"> </div> <div id="el43_ct" class="pw-tooltip" data-id="43"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/p300">p300</a><br> <a target="_blank" href="/target/cbp">CBP</a><br> </div> </div> <div id="el44_gry" class="hif_all hif_hypoxia pw-label el-gray44 pw-gray" style="top:469px;left:491px;"> p300/CBP </div> <div id="el44_off" data-id="44" data-set="p300CBP22" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off44" style="top:469px;left:491px;"> p300/CBP</div> <div id="el44_ct" class="pw-tooltip" data-id="44"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/p300">p300</a><br> <a target="_blank" href="/target/cbp">CBP</a><br> </div> </div> <div id="el45_gry" class="hif_all hif_hypoxia pw-sprite el-gray45 pw-gray" style="top:500px;left:458px;"> </div> <div id="el45_off" data-id="45" data-set="ARNT23" data-type="No Products Click" class="hif_all hif_hypoxia pw-sprite el-off45" style="top:500px;left:458px;"> </div> <div id="el45_ct" class="pw-tooltip" data-id="45"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/arnt-hif-1-beta">ARNT/HIF-1 beta</a><br> </div> </div> <div id="el46_gry" class="hif_all hif_hypoxia pw-label el-gray46 pw-gray" style="top:489px;left:494px;"> ARNT </div> <div id="el46_off" data-id="46" data-set="ARNT23" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off46" style="top:489px;left:494px;"> ARNT</div> <div id="el46_ct" class="pw-tooltip" data-id="46"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/arnt-hif-1-beta">ARNT/HIF-1 beta</a><br> </div> </div> <div id="el47_gry" class="hif_all hif_hypoxia pw-sprite el-gray47 pw-gray" style="top:506px;left:247px;"> </div> <div id="el47_off" data-id="47" data-set="SENP124" data-type="No Products Click" class="hif_all hif_hypoxia pw-sprite el-off47" style="top:506px;left:247px;"> </div> <div id="el47_ct" class="pw-tooltip" data-id="47"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/senp1">SENP1</a><br> </div> </div> <div id="el48_gry" class="hif_all hif_hypoxia pw-label el-gray48 pw-gray" style="top:515px;left:279px;"> SENP1 </div> <div id="el48_off" data-id="48" data-set="SENP124" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off48" style="top:515px;left:279px;"> SENP1</div> <div id="el48_ct" class="pw-tooltip" data-id="48"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/senp1">SENP1</a><br> </div> </div> <div id="el49_gry" class="hif_all hif_hypoxia pw-sprite el-gray49 pw-gray" style="top:480px;left:180px;"> </div> <div id="el49_off" data-id="49" data-set="HIF-1alpha25" data-type="No Products Click" class="hif_all hif_hypoxia pw-sprite el-off49" style="top:480px;left:180px;"> </div> <div id="el49_ct" class="pw-tooltip" data-id="49"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-1-alpha">HIF-1 alpha</a><br> <a target="_blank" href="/target/sumo">SUMO</a><br> <a target="_blank" href="/target/sumo1">SUMO1</a><br> <a target="_blank" href="/target/sumo1/2/3">SUMO1/2/3</a><br> <a target="_blank" href="/target/sumo2/3/4">SUMO2/3/4</a><br> <a target="_blank" href="/target/sumo3">SUMO3</a><br> <a target="_blank" href="/target/sumo4">SUMO4</a><br> </div> </div> <div id="el50_gry" class="hif_all hif_hypoxia pw-label el-gray50 pw-gray" style="top:477px;left:121px;"> HIF-1 alpha </div> <div id="el50_off" data-id="50" data-set="HIF-1alpha25" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off50" style="top:477px;left:121px;"> HIF-1 alpha</div> <div id="el50_ct" class="pw-tooltip" data-id="50"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-1-alpha">HIF-1 alpha</a><br> <a target="_blank" href="/target/sumo">SUMO</a><br> <a target="_blank" href="/target/sumo1">SUMO1</a><br> <a target="_blank" href="/target/sumo1/2/3">SUMO1/2/3</a><br> <a target="_blank" href="/target/sumo2/3/4">SUMO2/3/4</a><br> <a target="_blank" href="/target/sumo3">SUMO3</a><br> <a target="_blank" href="/target/sumo4">SUMO4</a><br> </div> </div> <div id="el51_gry" class="hif_all hif_hypoxia pw-sprite el-gray51 pw-gray" style="top:489px;left:163px;"> </div> <div id="el51_off" data-id="51" data-set="PIASy26" data-type="No Products Click" class="hif_all hif_hypoxia pw-sprite el-off51" style="top:489px;left:163px;"> </div> <div id="el51_ct" class="pw-tooltip" data-id="51"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=PIASy%2FPIAS4">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el52_gry" class="hif_all hif_hypoxia pw-label el-gray52 pw-gray" style="top:495px;left:131px;"> PIASy </div> <div id="el52_off" data-id="52" data-set="PIASy26" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off52" style="top:495px;left:131px;"> PIASy</div> <div id="el52_ct" class="pw-tooltip" data-id="52"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=PIASy%2FPIAS4">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el53_gry" class="hif_all hif_hypoxia pw-sprite el-gray53 pw-gray" style="top:509px;left:166px;"> </div> <div id="el53_off" data-id="53" data-set="Ubc927" data-type="No Products Click" class="hif_all hif_hypoxia pw-sprite el-off53" style="top:509px;left:166px;"> </div> <div id="el53_ct" class="pw-tooltip" data-id="53"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ube2i-ubc9">UBE2I/Ubc9</a><br> </div> </div> <div id="el54_gry" class="hif_all hif_hypoxia pw-label el-gray54 pw-gray" style="top:518px;left:141px;"> Ubc9 </div> <div id="el54_off" data-id="54" data-set="Ubc927" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off54" style="top:518px;left:141px;"> Ubc9</div> <div id="el54_ct" class="pw-tooltip" data-id="54"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ube2i-ubc9">UBE2I/Ubc9</a><br> </div> </div> <div id="el55_gry" class="hif_all hif_hypoxia pw-sprite el-gray55 pw-gray" style="top:570px;left:116px;"> </div> <div id="el55_off" data-id="55" data-set="HIF-1alpha28" data-type="No Products Click" class="hif_all hif_hypoxia pw-sprite el-off55" style="top:570px;left:116px;"> </div> <div id="el55_ct" class="pw-tooltip" data-id="55"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-1-alpha">HIF-1 alpha</a><br> <a target="_blank" href="/target/ubiquitin">Ubiquitin</a><br> <a target="_blank" href="/target/sumo">SUMO</a><br> <a target="_blank" href="/target/sumo1">SUMO1</a><br> <a target="_blank" href="/target/sumo1/2/3">SUMO1/2/3</a><br> <a target="_blank" href="/target/sumo2/3/4">SUMO2/3/4</a><br> <a target="_blank" href="/target/sumo3">SUMO3</a><br> <a target="_blank" href="/target/sumo4">SUMO4</a><br> </div> </div> <div id="el56_gry" class="hif_all hif_hypoxia pw-label el-gray56 pw-gray" style="top:569px;left:57px;"> HIF-1 alpha </div> <div id="el56_off" data-id="56" data-set="HIF-1alpha28" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off56" style="top:569px;left:57px;"> HIF-1 alpha</div> <div id="el56_ct" class="pw-tooltip" data-id="56"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/hif-1-alpha">HIF-1 alpha</a><br> <a target="_blank" href="/target/ubiquitin">Ubiquitin</a><br> <a target="_blank" href="/target/sumo">SUMO</a><br> <a target="_blank" href="/target/sumo1">SUMO1</a><br> <a target="_blank" href="/target/sumo1/2/3">SUMO1/2/3</a><br> <a target="_blank" href="/target/sumo2/3/4">SUMO2/3/4</a><br> <a target="_blank" href="/target/sumo3">SUMO3</a><br> <a target="_blank" href="/target/sumo4">SUMO4</a><br> </div> </div> <div id="el57_gry" class="hif_all hif_hypoxia pw-sprite el-gray57 pw-gray" style="top:597px;left:114px;"> </div> <div id="el57_off" data-id="57" data-set="pVHL29" data-type="No Products Click" class="hif_all hif_hypoxia pw-sprite el-off57" style="top:597px;left:114px;"> </div> <div id="el57_ct" class="pw-tooltip" data-id="57"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=pVHL">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el58_gry" class="hif_all hif_hypoxia pw-label el-gray58 pw-gray" style="top:607px;left:145px;"> pVHL </div> <div id="el58_off" data-id="58" data-set="pVHL29" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off58" style="top:607px;left:145px;"> pVHL</div> <div id="el58_ct" class="pw-tooltip" data-id="58"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=pVHL">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el59_gry" class="hif_all hif_hypoxia pw-sprite el-gray59 pw-gray" style="top:640px;left:36px;"> </div> <div id="el59_off" data-id="59" data-set="Proteasome30" data-type="No Products Click" class="hif_all hif_hypoxia pw-sprite el-off59" style="top:640px;left:36px;"> </div> <div id="el59_ct" class="pw-tooltip" data-id="59"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/26s-proteasome">26S Proteasome</a><br> <a target="_blank" href="/target/19s-proteasome">19S Proteasome</a><br> <a target="_blank" href="/target/20s-proteasome">20S Proteasome</a><br> </div> </div> <div id="el60_gry" class="hif_all hif_hypoxia pw-label el-gray60 pw-gray" style="top:658px;left:71px;"> 26S Proteasome </div> <div id="el60_off" data-id="60" data-set="Proteasome30" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off60" style="top:658px;left:71px;"> 26S Proteasome</div> <div id="el60_ct" class="pw-tooltip" data-id="60"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/26s-proteasome">26S Proteasome</a><br> <a target="_blank" href="/target/19s-proteasome">19S Proteasome</a><br> <a target="_blank" href="/target/20s-proteasome">20S Proteasome</a><br> </div> </div> <div id="el61_gry" class="hif_all hif_normoxia pw-label2 el-gray61 pw-gray" style="top:125px;left:204px;"> <div class="pw_txtBox">Normoxia</div> </div> <div id="el61_off" data-id="61" data-set="Normoxia" data-type="" class="hif_all hif_normoxia pw-label2 el-off61" style="top:125px;left:204px;"> <div class="pw_txtBox">Normoxia</div></div> <div id="el61_ct" class="pw-tooltip" data-id="61"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el62_gry" class="hif_all hif_hypoxia pw-label2 el-gray62 pw-gray" style="top:309px;left:224px;"> <div class="pw_txtBox">Hypoxia</div> </div> <div id="el62_off" data-id="62" data-set="Hypoxia" data-type="" class="hif_all hif_hypoxia pw-label2 el-off62" 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target="_blank" href="/target/angiopoietin-like-protein-4-angptl4">Angiopoietin-like Protein 4/ANGPTL4</a><br> <a target="_blank" href="/target/cxcl12-sdf-1">CXCL12/SDF-1</a><br> <a target="_blank" href="/target/endoglin-cd105">Endoglin/CD105</a><br> <a target="_blank" href="/target/fgf-3">FGF-3</a><br> <a target="_blank" href="/target/fibronectin">Fibronectin</a><br> <a target="_blank" href="/target/pdgf">PDGF</a><br> <a target="_blank" href="/target/plgf">PlGF</a><br> <a target="_blank" href="/target/serpin-e1-pai-1">Serpin E1/PAI-1</a><br> <a target="_blank" href="/target/tgf-beta-1">TGF-beta 1</a><br> <a target="_blank" href="/target/tgf-beta-3">TGF-beta 3</a><br> <a target="_blank" href="/target/vegf">VEGF</a><br> <a target="_blank" href="/target/vegf R1/Flt-1">VEGF R1/Flt-1</a><br> <a target="_blank" href="/target/vegf R2/KDR/Flk-1">VEGF R2/KDR/Flk-1</a><br> </div> </div> <div id="el64_gry" class="hif_all hif_hypoxia pw-label el-gray64 pw-gray" style="top:523px;left:525px;"> EMT </div> <div id="el64_off" data-id="64" data-set="EMT" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off64" style="top:523px;left:525px;"> EMT</div> <div id="el64_ct" class="pw-tooltip" data-id="64"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/cathepsin-d">Cathepsin D</a><br> <a target="_blank" href="/target/ccl2-je-mcp-1">CCL2/JE/MCP-1</a><br> <a target="_blank" href="/target/ctgf-ccn2">CTGF/CCN2</a><br> <a target="_blank" href="/target/cxcr4">CXCR4</a><br> <a target="_blank" href="/target/snail">Snail</a><br> <a target="_blank" href="/target/twist-1">Twist-1</a><br> </div> </div> <div id="el65_gry" class="hif_all hif_hypoxia pw-label el-gray65 pw-gray" style="top:541px;left:525px;"> Survival/Proliferation </div> <div id="el65_off" data-id="65" data-set="SurvivalProliferation" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off65" 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<div id="el66_off" data-id="66" data-set="Metastasis" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off66" style="top:559px;left:525px;"> Metastasis</div> <div id="el66_ct" class="pw-tooltip" data-id="66"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/cxcl8-il-8">CXCL8/IL-8</a><br> <a target="_blank" href="/target/hgf-r-c-met">HGF R/c-MET</a><br> <a target="_blank" href="/target/il-6">IL-6</a><br> <a target="_blank" href="/target/integrin-alpha-5-cd49e">Integrin alpha 5/CD49e</a><br> <a target="_blank" href="/target/lox-1-olr1">LOX-1/OLR1</a><br> <a target="_blank" href="/target/lysyl-oxidase-homolog-2-loxl2">Lysyl Oxidase Homolog 2/LOXL2</a><br> <a target="_blank" href="/target/mkp-1">MKP-1</a><br> <a target="_blank" href="/target/mmp-1">MMP-1</a><br> <a target="_blank" href="/target/mmp-2">MMP-2</a><br> <a target="_blank" href="/target/mmp-9">MMP-9</a><br> <a target="_blank" href="/target/osteopontin-opn">Osteopontin/OPN</a><br> <a target="_blank" href="/target/pref-1-dlk1-fa1">Pref-1/DLK1/FA1</a><br> <a target="_blank" href="/target/tcf-3-e2a">TCF-3/E2A</a><br> <a target="_blank" href="/target/trkb">TrkB</a><br> <a target="_blank" href="/target/upar">uPAR</a><br> <a target="_blank" href="/target/zeb1">ZEB1</a><br> </div> </div> <div id="el67_gry" class="hif_all hif_hypoxia pw-label el-gray67 pw-gray" style="top:577px;left:525px;"> Glycolysis </div> <div id="el67_off" data-id="67" data-set="Glycolysis" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off67" style="top:577px;left:525px;"> Glycolysis</div> <div id="el67_ct" class="pw-tooltip" data-id="67"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/carbonic-anhydrase-ix-ca9">Carbonic Anhydrase IX/CA9</a><br> <a target="_blank" href="/target/gapdh">GAPDH</a><br> <a target="_blank" href="/target/glut1">Glut1</a><br> <a target="_blank" href="/target/glut3">Glut3</a><br> <a target="_blank" href="/target/hexokinase-1">Hexokinase 1</a><br> <a target="_blank" href="/target/hexokinase-2">Hexokinase 2</a><br> <a target="_blank" href="/target/inos">iNOS</a><br> <a target="_blank" href="/target/lactate-dehydrogenase-a-ldha">Lactate Dehydrogenase A/LDHA</a><br> <a target="_blank" href="/target/perilipin-2">Perilipin-2</a><br> <a target="_blank" href="/target/pgk1">PGK1</a><br> <a target="_blank" href="/target/pkm2">PKM2</a><br> </div> </div> <div id="el68_gry" class="hif_all hif_hypoxia pw-label el-gray68 pw-gray" style="top:595px;left:525px;"> Pluripotency </div> <div id="el68_off" data-id="68" data-set="Pluripotency" data-type="No Products Click" class="hif_all hif_hypoxia pw-label el-off68" style="top:595px;left:525px;"> Pluripotency</div> <div id="el68_ct" class="pw-tooltip" data-id="68"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/klf4">KLF4</a><br> <a target="_blank" href="/target/nanog">Nanog</a><br> <a target="_blank" href="/target/oct-3-4">Oct-3/4</a><br> <a target="_blank" href="/target/oct-4a">Oct-4A</a><br> <a target="_blank" href="/target/sox2">SOX2</a><br> </div> </div> </div> <div id="pw-img"> <img id="cont-img" src="https://resources.rndsystems.com/images/Pathways/pathway-images/hif_all.png" alt="HIF Stability and Activity Pathways" style="height:750px"> </div> </div> <div id="pathway-description"><h2>Overview of HIF Transcription Factor Stability and Activity</h2><p><p>Hypoxia Inducible Factors (HIFs) are transcription factors that are stabilized mainly in response to decreased oxygen availability. Stabilized HIF induces the expression of target genes that act to maintain biological homeostasis. The functional HIF transcription factors consist of an unstable, constitutively expressed alpha subunit (HIF-1, HIF-2 or HIF-3) and a stable, constitutively expressed beta subunit (ARNT; also known as HIF-1 beta). Of the alpha subunits, HIF-1 alpha is the most extensively studied, followed by HIF-2 alpha and HIF-3 alpha, about which the least is known. The regulation of HIF-1 alpha and HIF-2 alpha stability during normoxia and hypoxia by the von Hippel-Lindau protein (pVHL) and other ubiquitin E3 ligases is displayed below. When HIF-1 alpha and HIF-2 alpha are stable, they are able to translocate to the nucleus where they individually dimerize with ARNT to form either the HIF-1 or HIF-2 transcription factor, respectively. HIF-1 and HIF-2 bind hypoxic response elements (HREs) within the promoters of hypoxic responsive genes and interact with co-activators, including p300/CBP, to activate transcription. Hypoxic responsive genes code for proteins that are involved in angiogenesis, epithelial-to-mesenchymal transition (EMT), survival, proliferation, metastasis, glycolysis, and pluripotency. HIF-1 and HIF-2 transcriptional activity can be modulated by both repressors and enhancers. HIF transcriptional activity can be repressed via post-translational modifications and protein-protein interactions that block the binding of HIF alpha subunits to ARNT and p300/CBP. There are also post-translational modifications and protein-protein interactions that enhance the transactivation of HIF, including SUMOylation of HIF-1 alpha by Cbx4 and the binding of SART1/HAF to HIF-2 alpha. HIF-1 alpha activity in tumors correlates with increased angiogenesis and tumor growth, which has led to the investigation of HIF-1 alpha as a pharmacological target.</p>  <p>To learn more, please visit our <a href="https://www.rndsystems.com/research-area/hif-transcription-factors">HIF Transcription Factors Research Area</a>.</p></p></div> <div id="print-copy-form" class="accordion-wrapper"> <h3 class="builder-header builder-bead-type ui-accordion-header ui-helper-reset ui-state-default ui-corner-all ui-accordion-icons" data-toggle="collapse" data-target="#collapsePathwayRequest" aria-expanded="false" id="pathwayRequestAccordionHeader"> <span class="ui-accordion-header-icon" id="accordionArrow"></span> Get Print Copy of this Pathway </h3> <div class="collapse" id="collapsePathwayRequest"> <div id="pathwayRequestWebformWrapper"> <form class="webform-client-form webform-client-form-27981" action="/pathways/hif-stability-activity-pathways" method="post" id="webform-client-form-27981" accept-charset="UTF-8"><div><div class="form-item webform-component webform-component-textfield webform-component--first-name form-group form-item form-item-submitted-first-name form-type-textfield form-group"> <label class="control-label" for="edit-submitted-first-name">First Name <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" type="text" id="edit-submitted-first-name" name="submitted[first_name]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-textfield webform-component--last-name form-group form-item form-item-submitted-last-name form-type-textfield form-group"> <label class="control-label" for="edit-submitted-last-name">Last Name <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" type="text" id="edit-submitted-last-name" name="submitted[last_name]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-email webform-component--email-address form-group form-item form-item-submitted-email-address form-type-webform-email form-group"> <label class="control-label" for="edit-submitted-email-address">Email Address <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="email form-control form-text form-email required" type="email" id="edit-submitted-email-address" name="submitted[email_address]" size="60" /></div><div class="form-item webform-component webform-component-textfield webform-component--institution form-group form-item form-item-submitted-institution form-type-textfield form-group"> <label class="control-label" for="edit-submitted-institution">Institution <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" 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webform-component-textfield webform-component--address-1 form-group form-item form-item-submitted-address-1 form-type-textfield form-group"> <label class="control-label" for="edit-submitted-address-1">Address 1 <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" type="text" id="edit-submitted-address-1" name="submitted[address_1]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-textfield webform-component--address-2 form-group form-item form-item-submitted-address-2 form-type-textfield form-group"> <label class="control-label" for="edit-submitted-address-2">Address 2</label> <input class="form-control form-text" type="text" id="edit-submitted-address-2" name="submitted[address_2]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-textfield webform-component--city form-group form-item form-item-submitted-city form-type-textfield form-group"> <label class="control-label" for="edit-submitted-city">City <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" type="text" id="edit-submitted-city" name="submitted[city]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-select webform-component--state form-group form-item form-item-submitted-state form-type-select form-group"> <label class="control-label" for="edit-submitted-state">State</label> <div class="select_wrapper"><select class="form-control form-select" id="edit-submitted-state" name="submitted[state]"><option value="" selected="selected">- None -</option><option value="AL">Alabama</option><option value="AK">Alaska</option><option value="AS">American Samoa</option><option value="AZ">Arizona</option><option value="AR">Arkansas</option><option value="CA">California</option><option value="CO">Colorado</option><option value="CT">Connecticut</option><option value="DE">Delaware</option><option value="DC">District of Columbia</option><option value="FL">Florida</option><option value="GA">Georgia</option><option value="GU">Guam</option><option value="HI">Hawaii</option><option value="ID">Idaho</option><option value="IL">Illinois</option><option value="IN">Indiana</option><option value="IA">Iowa</option><option value="KS">Kansas</option><option value="KY">Kentucky</option><option value="LA">Louisiana</option><option value="ME">Maine</option><option value="MH">Marshall Islands</option><option value="MD">Maryland</option><option value="MA">Massachusetts</option><option value="MI">Michigan</option><option value="MN">Minnesota</option><option value="MS">Mississippi</option><option value="MO">Missouri</option><option value="MT">Montana</option><option value="NE">Nebraska</option><option value="NV">Nevada</option><option value="NH">New 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