Chagas disease | Novartis

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alt="Mother and daughter cuddling on a bed in a kids room" title="Mother and daughter cuddling on a bed in a kids room"/> </div> <div class="section-content"> <p>About</p> </div> <div class="section-description" > <p><span lang="EN-GB">Novartis is an innovative medicines company. Every day, we work to reimagine medicine to improve and extend people’s lives so that patients, healthcare professionals and societies are empowered in the face of serious disease. Our medicines reach more than 250 million people worldwide.</span><span lang="EN-GB"></span></p> </div> </div> </div> </div></div> </div> </div> </div> </div> </li> <li class="we-mega-menu-li dropdown-menu" data-level="0" data-element-type="we-mega-menu-li" data-id="46c98121-e544-4ac9-bc64-a92da86975ca" data-submenu="1" data-group="0" data-class="" data-icon="" data-caption="" data-alignsub="" data-target=""> <i class="borderH"></i> <a class="we-mega-menu-li" title="Patients and caregivers" href="/patients-and-caregivers" > <i class="borderH"></i> Patients and caregivers  </a> <div class="we-mega-menu-submenu" data-element-type="we-mega-menu-submenu"> <span class="more_from"></span> <div class="we-mega-menu-submenu-inner"> <div class="we-mega-menu-row" data-element-type="we-mega-menu-row" data-custom-row="1"> <div class="we-mega-menu-col span6" data-element-type="we-mega-menu-col" data-width="6" data-block="" data-blocktitle="0" data-hidewhencollapse="" data-class=""> <ul class="nav 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Explore the Novartis in Society Integrated Report.</p> </div> </div> </div> </div></div> </div> </div> </div> </div> </li> <li class="we-mega-menu-li dropdown-menu" data-level="0" data-element-type="we-mega-menu-li" data-id="201d99e2-cf92-4d8f-adb4-ba5c192edb83" data-submenu="1" data-group="0" data-class="" data-icon="" data-caption="" data-alignsub="" data-target=""> <i class="borderH"></i> <a class="we-mega-menu-li" title="Investors" href="/investors" > <i class="borderH"></i> Investors  </a> <div class="we-mega-menu-submenu" data-element-type="we-mega-menu-submenu"> <span class="more_from"></span> <div class="we-mega-menu-submenu-inner"> <div class="we-mega-menu-row" data-element-type="we-mega-menu-row" data-custom-row="1"> <div class="we-mega-menu-col span6" data-element-type="we-mega-menu-col" data-width="6" data-block="" data-blocktitle="0" data-hidewhencollapse="" data-class=""> <ul class="nav nav-tabs subul"> <li class="we-mega-menu-li" data-level="1" 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id="main-wrapper" class="layout-main-wrapper clearfix"> <div class="highlighted"> <div class="container section clearfix"> <div data-drupal-messages-fallback class="hidden"></div> </div> </div> <section class="row region region-hero-banner"> </section> <div class="background_stripe"> </div> <div class="container"> <div id="block-polaris-breadcrumbs" data-block-plugin-id="system_breadcrumb_block" class="block block-system block-system-breadcrumb-block"> <div class="content"> <nav role="navigation" aria-label="breadcrumb" class="breadcrumb_custom_class"> <ol class="breadcrumb custom-breadcrumb"> <li class="breadcrumb-item"> <a href="/">Home</a> </li> <li class="breadcrumb-item"> <a href="https://www.novartis.com/diseases">Diseases</a> </li> <li class="breadcrumb-item"> <a href="https://www.novartis.com/diseases/chagas-disease">Chagas disease</a> </li> </ol> </nav> </div> </div> </div> <div class="container"> <div class="page_title "> <section class="row region region-page-title"> <div id="block-polaris-page-title" data-block-plugin-id="page_title_block" class="block block-core block-page-title-block"> <div class="content"> <h1 class="title"><span class="field field--name-title field--type-string field--label-hidden">Chagas disease</span> </h1> </div> </div> </section> </div> </div> <div id="main" class="container-fluid custom_width"> <div class="row row-offcanvas row-offcanvas-left clearfix"> <div class="container"> <div class="main-content col order-last col-md-12 column-full" id="content"> <section class="section"> <div id="block-polaris-content" data-block-plugin-id="system_main_block" class="block block-system block-system-main-block"> <div class="content"> <div about="/diseases/chagas-disease" class="node node--type-interior-page node--view-mode-full clearfix"> <header> </header> <div class="node__content clearfix"> <div class="page_content"> <div class="row content_middle"> <div class="col-sm-12 content_left_side"> <div class="field_body_txt "> <div class="field field--name-field-body field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--rich-text-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-with-summary field--label-hidden field__item"><p>Chagas disease, also known as American trypanosomiasis, is a potentially life-threatening illness caused by the protozoan parasite <em>Trypanosoma cruzi</em><sup>1</sup>.</p><p>The disease affects approximately 6 million people<sup>1</sup>, mainly in Latin America. Less than 1% of affected individuals receive proper treatment<sup>2</sup>, and current available drugs have high rates of adverse effects and do not meet the need for the entire spectrum of the disease. Chagas disease usually begins with a bite by the triatomine bug, also known as the “kissing bug” because it usually bites people’s faces when they sleep. Often people are infected without even noticing it.</p><div class="align-center"> <div class="field field--name-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/novartis_com/files/styles/crop_freeform/public/2021-09/male-chagas-disease-patient-brazil.jpg.webp?itok=mcRjYTKJ" width="800" height="600" alt="Chagas disease patient in Bahia, Brazil" title="Chagas disease patient in Bahia, Brazil" typeof="foaf:Image" class="image-style-crop-freeform"> </div> </div> <p><span></span></p><p>The disease sits at the crossroads between two worlds: it starts as a tropical parasitic disease but can end as a chronic disease. This is why preventing, treating and managing Chagas disease requires an integrated, end-to-end approach that covers both the acute and chronic phases. </p><p>Improving health outcomes for Chagas patients also requires being active on three fronts: novel drug discovery, clinical development, and healthcare system strengthening.</p><p>Together with strong partners, our <a href="/research-and-development/research-disease-areas/global-health-disease-area-research-novartis" data-entity-type="node" data-entity-uuid="e8b30449-f2d5-41a4-a486-09031360d4cc" data-entity-substitution="canonical" title="Global Health disease area research at Novartis">Biomedical Research teams focused on Global Health</a> are discovering novel parasite-specific growth inhibitors for the treatment of Chagas disease and other kinetoplastid diseases. </p><p>During the chronic phase, when the disease evolves, it can affect key organs as the heart, leading to cardiac disorders in up to 30% of patients and up to 10% may develop neurological and/or gastrointestinal disorders. Chagas cardiomyopathy accounts for the majority of death and disability among individuals affected by the disease. Against this background, in 2019, in collaboration with the Brazilian Clinical Research Institute, Novartis launched the first clinical study in people with heart failure due to chronic Chagas cardiomyopathy to assess an innovative therapy in this underserved patient population. This Phase IV trial also includes sub-studies that may help better understand the underlying pathophysiology of Chagas cardiomyopathy (biomarkers, arrhythmia burden, and use of magnetic resonance imaging to evaluate cardiac structure, function and fibrosis).</p><p>Further, we are working with health authorities and stakeholders in Latin America on healthcare system strengthening initiatives to improve health outcomes and access to innovation. For example, Novartis signed a collaboration agreement with IS Global to improve the well-being of Chagas patients in Bolivia. Aiming for long-term sustainability, local empowerment and impact, the interventions are implemented in phases hand-in-hand with Bolivian and regional stakeholders. In 2022, we were involved in a capability-building program, reaching more than 200 healthcare professionals.  We are also collaborating with the Global Chagas Disease Coalition to develop an online medical platform for Chagas disease, which aims to build capability among healthcare professionals to adopt an integrated disease management approach.  <br> <br>We supported the World Heart Federation (WHF) and the Inter-American Society of Cardiology in developing an <a href="https://www.world-heart-federation.org/cvd-roadmaps/chagas/" target="_blank" rel="noopener noreferrer">end-to-end roadmap for Chagas disease</a>, published in 2020. It explores the patient journey from diagnosis to treatment, and provides actionable recommendations for policymakers and healthcare professionals.  In 2022, under a research collaboration with the WHF and the Federal University of Minas Gerais in Brazil, we kicked off the RAISE study (The buRden of ChAgas dISEase in the contemporary world) to assess the health and economic burden of Chagas disease globally.</p><p>In 2019, Novartis joined the <a href="http://www.coalicionchagas.org/en/" target="_blank">Global Chagas Disease Coalition</a>, an alliance to increase disease awareness and foster synergies in controlling the disease and promoting access to diagnosis and treatment. </p><p><a href="/news/media-releases/novartis-joins-global-chagas-disease-coalition-and-also-announces-first-multinational-prospective-randomized-study-people-chronic-chagas-cardiomyopathy">Read the press release</a></p><p><a href="/node/16466">Download Chagas Disease factsheet</a></p><p><a href="/stories/bringing-chagas-disease-peoples-attention" data-entity-type="node" data-entity-uuid="0d30ddc7-b4cf-4de5-be1e-e8bdf9624b91" data-entity-substitution="canonical" title="Bringing Chagas disease to people’s attention">Read the photo story Chagas Disease: Bringing Chagas disease to people’s attention</a></p><p><a href="/stories/chagas-disease-breaking-silence" data-entity-type="node" data-entity-uuid="d469fab7-fb8e-4e38-85fc-5109d63022c0" data-entity-substitution="canonical" title="Chagas disease: Breaking the silence">Read the photo story Chagas Disease: Breaking the silence</a></p></div> </div> </div> <div class="field__item"> <div class="cta-teaser"> <h3 class="cta_title " > Reimagining the fight against Chagas disease </h3> <div class="cta_description"> <div class="clearfix text-formatted field field--name-field-cta-description field--type-text-with-summary field--label-hidden field__item"><p>Together with partners, Novartis is committed to reimagining the fight against Chagas disease and advocating for an integrated, end-to-end care approach.</p></div> </div> <a class="link_button button_text" href="/news/world-chagas-disease-day-2021" target="_self" title="Learn More" >Learn More</a> </div> </div> </div> </div> </div> </div> <div class="content_bottom"> <div class="clearfix text-formatted field field--name-field-legend field--type-text-with-summary field--label-hidden field__item"><p>References:</p> <ol> <li>World Health Organization: <a href="https://www.who.int/en/news-room/fact-sheets/detail/chagas-disease-(american-trypanosomiasis)" target="_blank">https://www.who.int/en/news-room/fact-sheets/detail/chagas-disease-(american-trypanosomiasis)</a></li> <li>Barcelona Institute for Global Health: <a href="https://www.isglobal.org/en/enfermedad-de-chagas" target="_blank">https://www.isglobal.org/en/enfermedad-de-chagas</a></li> </ol></div> <div class="field field--name-field-protected field--type-nc-content-protection-code field--label-hidden 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