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Brain-Derived Neurotrophic Factor (BDNF)</title> <meta name="description" content="Search results for: Brain-Derived Neurotrophic Factor (BDNF)"> <meta name="keywords" content="Brain-Derived Neurotrophic Factor (BDNF)"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open 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class="col-md-9 mx-auto"> <form method="get" action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Brain-Derived Neurotrophic Factor (BDNF)"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 5258</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Brain-Derived Neurotrophic Factor (BDNF)</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5258</span> Association of Brain-Derived Neurotrophic Factor (BDNF) Gene with Obesity and Metabolic Traits in Malaysian Adults</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yamunah%20Devi%20Apalasamy">Yamunah Devi Apalasamy</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanjay%20Rampal"> Sanjay Rampal</a>, <a href="https://publications.waset.org/abstracts/search?q=Tin%20Tin%20Su"> Tin Tin Su</a>, <a href="https://publications.waset.org/abstracts/search?q=Foong%20Ming%20Moy"> Foong Ming Moy</a>, <a href="https://publications.waset.org/abstracts/search?q=Hazreen%20Abdul%20Majid"> Hazreen Abdul Majid</a>, <a href="https://publications.waset.org/abstracts/search?q=Awang%20Bulgiba"> Awang Bulgiba</a>, <a href="https://publications.waset.org/abstracts/search?q=Zahurin%20Mohamed"> Zahurin Mohamed</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Obesity is a growing global health issue. Obesity results from a combination of environmental and genetics factors. Brain-derived neurotrophic factor (BDNF), a gene encodes the BDNF protein and the BDNF gene have been linked to regulation of body weight and appetite. Genome-wide association studies have identified the BDNF variants to be related to obesity among Caucasians, East Asians, and Filipinos. However, the role of BDNF in other ethnic groups remains inconclusive. This case control study aims to investigate the associations of BDNF gene polymorphisms with obesity and metabolic parameters in Malaysian Malays. BDNF rs4074134, BDNF rs10501087 and BDNF rs6265 were genotyped using Sequenom MassARRAY. Anthropometric, body fat, fasting lipids and glucose levels were measured. A total of 663 subjects (194 obese and 469 non-obese) were included in this study. There were no significant associations association between BDNF SNPs and obesity. The allelic and genotype frequencies of the BDNF SNPs were similar in the obese and non-obese groups. After adjustment for age and sex, the BDNF variants were not associated with obesity, body fat, fasting lipids and glucose levels. Haplotypes at the BDNF gene region, were not significantly associated with obesity. The BDNF rs4074134 was in strong LD with BDNF rs10501087 (D'=0.98) and BDNF rs6265 (D'=0.87). The BDNF rs10501087 was also in strong LD with BDNF rs6265 (D'=0.91). Our findings suggest that the BDNF variants and the haplotypes of BDNF gene were not associated with obesity and metabolic traits in this study population. Further research is needed to explore other BDNF variants with a larger sample size with gene-environment interactions in multi ethnic Malaysian population. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=genomics%20of%20obesity" title="genomics of obesity">genomics of obesity</a>, <a href="https://publications.waset.org/abstracts/search?q=SNP" title=" SNP"> SNP</a>, <a href="https://publications.waset.org/abstracts/search?q=BMI" title=" BMI"> BMI</a>, <a href="https://publications.waset.org/abstracts/search?q=haplotypes" title=" haplotypes"> haplotypes</a> </p> <a href="https://publications.waset.org/abstracts/25497/association-of-brain-derived-neurotrophic-factor-bdnf-gene-with-obesity-and-metabolic-traits-in-malaysian-adults" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/25497.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">430</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5257</span> Brain-Derived Neurotrophic Factor and It's Precursor ProBDNF Serum Levels in Adolescents with Mood Disorders: 2-Year Follow-Up Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20Skibinska">M. Skibinska</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Rajewska-Rager"> A. Rajewska-Rager</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Dmitrzak-Weglarz"> M. Dmitrzak-Weglarz</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20Lepczynska"> N. Lepczynska</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Sibilski"> P. Sibilski</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Kapelski"> P. Kapelski</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20Pawlak"> J. Pawlak</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20Twarowska-Hauser"> J. Twarowska-Hauser</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Neurotrophic factors have been implicated in neuropsychiatric disorders. Brain-Derived Neurotrophic Factor (BDNF) influences neuron differentiation in development as well as synaptic plasticity and neuron survival in adulthood. BDNF is widely studied in mood disorders and has been proposed as a biomarker for depression. BDNF is synthesized as precursor protein – proBDNF. Both forms are biologically active and exert opposite effects on neurons. Aim: The aim of the study was to examine the serum levels of BDNF and proBDNF in unipolar and bipolar young patients below 24 years old during hypo/manic, depressive episodes and in remission compared to healthy control group. Methods: In a prospective 2 years follow-up study, we investigated alterations in levels of BDNF and proBDNF in 79 patients (23 males, mean age 19.08, SD 3.3 and 56 females, mean age 18.39, SD 3.28) diagnosed with mood disorders: unipolar and bipolar disorder compared with 35 healthy control subjects (7 males, mean age 20.43, SD 4.23 and 28 females, mean age 21.25, SD 2.11). Clinical characteristics including mood, comorbidity, family history, and treatment, were evaluated during control visits and clinical symptoms were rated using the Hamilton Depression Rating Scale and Young Mania Rating Scale. Serum BDNF and proBDNF concentrations were determined by Enzyme-Linked Immunosorbent Assays (ELISA) method. Serum BDNF and proBDNF levels were analysed with covariates: sex, age, age > 18 and < 18 years old, family history of affective disorders, drug-free vs. medicated status. Normality of the data was tested using Shapiro-Wilk test. Levene’s test was used to calculate homogeneity of variance. Non-parametric Tests: Mann-Whitney U test, Kruskal-Wallis ANOVA, Friedman’s ANOVA, Wilcoxon signed rank test, Spearman correlation coefficient were applied in analyses The statistical significance level was set at p < 0.05. Results: BDNF and proBDNF serum levels did not differ between patients at baseline and controls as well as comparing patients in acute episode of depression/hypo/mania at baseline and euthymia (at month 3 or 6). Comparing BDNF and proBDNF levels between patients in euthymia and control group no differences have been found. Increased BDNF level in women compared to men at baseline (p=0.01) have been observed. BDNF level at baseline was negatively correlated with depression and mania occurence at 24 month (p=0.04). BDNF level at 12 month was negatively correlated with depression and mania occurence at 12 month (p=0.01). Correlation of BDNF level with sex have been detected (p=0.01). proBDNF levels at month 3, 6 and 12 negatively correlated with disease status (p=0.02, p=0.008, p=0.009, respectively). No other correlations of BDNF and proBDNF levels with clinical and demographical variables have been detected. Discussion: Our results did not show any differences in BDNF and proBDNF levels between depression, mania, euthymia, and controls. Imbalance in BDNF/proBDNF signalling may be involved in pathogenesis of mood disorders. Further studies on larger groups are recommended. Grant was founded by National Science Center in Poland no 2011/03/D/NZ5/06146. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bipolar%20disorder" title="bipolar disorder">bipolar disorder</a>, <a href="https://publications.waset.org/abstracts/search?q=Brain-Derived%20Neurotrophic%20Factor%20%28BDNF%29" title=" Brain-Derived Neurotrophic Factor (BDNF)"> Brain-Derived Neurotrophic Factor (BDNF)</a>, <a href="https://publications.waset.org/abstracts/search?q=proBDNF" title=" proBDNF"> proBDNF</a>, <a href="https://publications.waset.org/abstracts/search?q=unipolar%20depression" title=" unipolar depression"> unipolar depression</a> </p> <a href="https://publications.waset.org/abstracts/77895/brain-derived-neurotrophic-factor-and-its-precursor-probdnf-serum-levels-in-adolescents-with-mood-disorders-2-year-follow-up-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/77895.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">244</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5256</span> Descriptive Study of Role Played by Exercise and Diet on Brain Plasticity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mridul%20Sharma">Mridul Sharma</a>, <a href="https://publications.waset.org/abstracts/search?q=Praveen%20Saroha"> Praveen Saroha</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In today's world, everyone has become so busy in their to-do tasks and daily routine that they tend to ignore some of the basal components of our life, including exercise and diet. This comparative study analyzes the pathways of the relationship between exercise and brain plasticity and also includes another variable diet to study the effects of diet on learning by answering questions including which diet is known to be the best learning supporter and what are the recommended quantities of the same. Further, this study looks into inter-relation between diet and exercise, and also some other approach of the relation between diet and exercise on learning apart from through Brain Derived Neurotrophic Factor (BDNF). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=brain%20derived%20neurotrophic%20factor" title="brain derived neurotrophic factor">brain derived neurotrophic factor</a>, <a href="https://publications.waset.org/abstracts/search?q=brain%20plasticity" title=" brain plasticity"> brain plasticity</a>, <a href="https://publications.waset.org/abstracts/search?q=diet" title=" diet"> diet</a>, <a href="https://publications.waset.org/abstracts/search?q=exercise" title=" exercise"> exercise</a> </p> <a href="https://publications.waset.org/abstracts/112374/descriptive-study-of-role-played-by-exercise-and-diet-on-brain-plasticity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/112374.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">141</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5255</span> Association of Brain Derived Neurotrophic Factor with Iron as well as Vitamin D, Folate and Cobalamin in Pediatric Metabolic Syndrome</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mustafa%20M.%20Donma">Mustafa M. Donma</a>, <a href="https://publications.waset.org/abstracts/search?q=Orkide%20Donma"> Orkide Donma</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The impact of metabolic syndrome (MetS) on cognition and functions of the brain is being investigated. Iron deficiency and deficiencies of B9 (folate) as well as B12 (cobalamin) vitamins are best-known nutritional anemias. They are associated with cognitive disorders and learning difficulties. The antidepressant effects of vitamin D are known and the deficiency state affects mental functions negatively. The aim of this study is to investigate possible correlations of MetS with serum brain-derived neurotrophic factor (BDNF), iron, folate, cobalamin and vitamin D in pediatric patients. 30 children, whose age- and sex-dependent body mass index (BMI) percentiles vary between 85 and 15, 60 morbid obese children with above 99<sup>th</sup> percentiles constituted the study population. Anthropometric measurements were taken. BMI values were calculated. Age- and sex-dependent BMI percentile values were obtained using the appropriate tables prepared by the World Health Organization (WHO). Obesity classification was performed according to WHO criteria. Those with MetS were evaluated according to MetS criteria. Serum BDNF was determined by enzyme-linked immunosorbent assay. Serum folate was analyzed by an immunoassay analyzer. Serum cobalamin concentrations were measured using electrochemiluminescence immunoassay. Vitamin D status was determined by the measurement of 25-hydroxycholecalciferol [25-hydroxy vitamin D3, 25(OH)D] using high performance liquid chromatography. Statistical evaluations were performed using SPSS for Windows, version 16. The p values less than 0.05 were accepted as statistically significant. Although statistically insignificant, lower folate and cobalamin values were found in MO children compared to those observed for children with normal BMI. For iron and BDNF values, no alterations were detected among the groups. Significantly decreased vitamin D concentrations were noted in MO children with MetS in comparison with those in children with normal BMI (p ≤ 0.05). The positive correlation observed between iron and BDNF in normal-BMI group was not found in two MO groups. In THE MetS group, the partial correlation among iron, BDNF, folate, cobalamin, vitamin D controlling for waist circumference and BMI was r = -0.501; p ≤ 0.05. None was calculated in MO and normal BMI groups. In conclusion, vitamin D should also be considered during the assessment of pediatric MetS. Waist circumference and BMI should collectively be evaluated during the evaluation of MetS in children. Within this context, BDNF appears to be a key biochemical parameter during the examination of obesity degree in terms of mental functions, cognition and learning capacity. The association observed between iron and BDNF in children with normal BMI was not detected in MO groups possibly due to development of inflammation and other obesity-related pathologies. It was suggested that this finding may contribute to mental function impairments commonly observed among obese children. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=brain-derived%20neurotrophic%20factor" title="brain-derived neurotrophic factor">brain-derived neurotrophic factor</a>, <a href="https://publications.waset.org/abstracts/search?q=iron" title=" iron"> iron</a>, <a href="https://publications.waset.org/abstracts/search?q=vitamin%20B9" title=" vitamin B9"> vitamin B9</a>, <a href="https://publications.waset.org/abstracts/search?q=vitamin%20B12" title=" vitamin B12"> vitamin B12</a>, <a href="https://publications.waset.org/abstracts/search?q=vitamin%20D" title=" vitamin D"> vitamin D</a> </p> <a href="https://publications.waset.org/abstracts/115068/association-of-brain-derived-neurotrophic-factor-with-iron-as-well-as-vitamin-d-folate-and-cobalamin-in-pediatric-metabolic-syndrome" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/115068.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">120</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5254</span> Role of Maternal Astaxanthin Supplementation on Brain Derived Neurotrophic Factor and Spatial Learning Behavior in Wistar Rat Offspring’s</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=K.%20M.%20Damodara%20Gowda">K. M. Damodara Gowda</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Maternal health and nutrition are considered as the predominant factors influencing brain functional development. If the mother is free of illness and genetic defects, maternal nutrition would be one of the most critical factors affecting the brain development. Calorie restrictions cause significant impairment in spatial learning ability and the levels of Brain Derived Neurotrophic Factor (BDNF) in rats. But, the mechanism by which the prenatal under-nutrition leads to impairment in brain learning and memory function is still unclear. In the present study, prenatal Astaxanthin supplementation on BDNF level, spatial learning and memory performance in the offspring’s of normal, calorie restricted and Astaxanthin supplemented rats was investigated. Methodology: The rats were administered with 6mg and 12 mg of astaxanthin /kg bw for 21 days following which acquisition and retention of spatial memory was tested in a partially-baited eight arm radial maze. The BDNF level in different regions of the brain (cerebral cortex, hippocampus and cerebellum) was estimated by ELISA method. Results: Calorie restricted animals treated with astaxanthin made significantly more correct choices (P < 0.05), and fewer reference memory errors (P < 0.05) on the tenth day of training compared to offsprings of calorie restricted animals. Calorie restricted animals treated with astaxanthin also made significantly higher correct choices (P < 0.001) than untreated calorie restricted animals in a retention test 10 days after the training period. The mean BDNF level in cerebral cortex, Hippocampus and cerebellum in Calorie restricted animals treated with astaxanthin didnot show significant variation from that of control animals. Conclusion: Findings of the study indicated that memory and learning was impaired in the offspring’s of calorie restricted rats which was effectively modulated by astaxanthin at the dosage of 12 mg/kg body weight. In the same way the BDNF level at cerebral cortex, Hippocampus and Cerebellum was also declined in the offspring’s of calorie restricted animals, which was also found to be effectively normalized by astaxanthin. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=calorie%20restiction" title="calorie restiction">calorie restiction</a>, <a href="https://publications.waset.org/abstracts/search?q=learning" title=" learning"> learning</a>, <a href="https://publications.waset.org/abstracts/search?q=Memory" title=" Memory"> Memory</a>, <a href="https://publications.waset.org/abstracts/search?q=Cerebral%20cortex" title=" Cerebral cortex"> Cerebral cortex</a>, <a href="https://publications.waset.org/abstracts/search?q=Hippocampus" title=" Hippocampus"> Hippocampus</a>, <a href="https://publications.waset.org/abstracts/search?q=Cerebellum" title=" Cerebellum"> Cerebellum</a>, <a href="https://publications.waset.org/abstracts/search?q=BDNF" title=" BDNF"> BDNF</a>, <a href="https://publications.waset.org/abstracts/search?q=Astaxanthin" title=" Astaxanthin"> Astaxanthin</a> </p> <a href="https://publications.waset.org/abstracts/65676/role-of-maternal-astaxanthin-supplementation-on-brain-derived-neurotrophic-factor-and-spatial-learning-behavior-in-wistar-rat-offsprings" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/65676.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">232</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5253</span> Brain Derived Neurotrophic Factor (BDNF) Down Regulation in Peritoneal Carcinomatosis Patients</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Awan%20A.%20Zaima">Awan A. Zaima</a>, <a href="https://publications.waset.org/abstracts/search?q=Tanvieer%20Ayesha"> Tanvieer Ayesha</a>, <a href="https://publications.waset.org/abstracts/search?q=Mirshahi%20Shahsoltan"> Mirshahi Shahsoltan</a>, <a href="https://publications.waset.org/abstracts/search?q=Pocard%20Marc"> Pocard Marc</a>, <a href="https://publications.waset.org/abstracts/search?q=Mirshahi%20Massoud"> Mirshahi Massoud</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Brain-derived neurotrophic factor (BDNF) is described as a factor helping to support the survival of existing neurons by involving the growth and differentiation of new neurons and synapses. Cancer diagnosis impacts the mental health, and in consequences, depression arise eventually hinders recovery and disrupts the quality of life and surviving chances of patients. The focus of this study is to hint upon a prospective biomarker as a promising diagnostic tool for an early indicator/predictor of depression prevalence in cancer patients for better care and treatment options. The study aims to analyze peripheral biomarkers from neuro immune axis (BDNF, IL21 as a NK cell activator) using co-relation approach. Samples were obtained from random non cancer candidates and advanced peritoneum carcinomatosis patients with 25% pseudomyxoma, 21% Colon cancer,19% stomach cancer, 10% ovarian cancer, 8% appendices cancer, and 10% other area of peritoneum cancer patients. Both groups of the study were categorized by gender and age, with a range of 18 to 86 years old. Biomarkers were analyzed in collected plasma by performing multiplex sandwich ELISA system. Data were subjected to statistical analysis for the assessment of the correlation. Our results demonstrate that BNDF and IL 21 down regulated significantly in patient groupas compared to non-cancer candidates (ratio of patients/normalis 2.57 for BNDF and 1.32 for IL21). This preliminary investigation suggested that the neuro immune biomarkers are down regulated in carcinomatosis patients and can be associated with cancer expansion and cancer genesis. Further studies on larger cohort are necessary to validate this hypothesis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biomarkers" title="biomarkers">biomarkers</a>, <a href="https://publications.waset.org/abstracts/search?q=depression" title=" depression"> depression</a>, <a href="https://publications.waset.org/abstracts/search?q=peritoneum%20carcinoma" title=" peritoneum carcinoma"> peritoneum carcinoma</a>, <a href="https://publications.waset.org/abstracts/search?q=BNDF" title=" BNDF"> BNDF</a>, <a href="https://publications.waset.org/abstracts/search?q=IL21" title=" IL21"> IL21</a> </p> <a href="https://publications.waset.org/abstracts/156053/brain-derived-neurotrophic-factor-bdnf-down-regulation-in-peritoneal-carcinomatosis-patients" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/156053.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">116</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5252</span> Temporal Profile of Exercise-Induced Changes in Plasma Brain-Derived Neurotrophic Factor Levels of Schizophrenic Individuals</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Caroline%20Lavratti">Caroline Lavratti</a>, <a href="https://publications.waset.org/abstracts/search?q=Pedro%20Dal%20Lago"> Pedro Dal Lago</a>, <a href="https://publications.waset.org/abstracts/search?q=Gustavo%20Reinaldo"> Gustavo Reinaldo</a>, <a href="https://publications.waset.org/abstracts/search?q=Gilson%20Dorneles"> Gilson Dorneles</a>, <a href="https://publications.waset.org/abstracts/search?q=Andreia%20Bard"> Andreia Bard</a>, <a href="https://publications.waset.org/abstracts/search?q=Laira%20Fuhr"> Laira Fuhr</a>, <a href="https://publications.waset.org/abstracts/search?q=Daniela%20Pochmann"> Daniela Pochmann</a>, <a href="https://publications.waset.org/abstracts/search?q=Alessandra%20Peres"> Alessandra Peres</a>, <a href="https://publications.waset.org/abstracts/search?q=Luciane%20Wagner"> Luciane Wagner</a>, <a href="https://publications.waset.org/abstracts/search?q=Viviane%20Elsner"> Viviane Elsner</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Approximately 1% of the world's population is affected by schizophrenia (SZ), a chronic and debilitating neurodevelopmental disorder. Among possible factors, reduced levels of Brain-derived neurotrophic factor (BDNF) has been recognized in physiopathogenesis and course of SZ. In this context, peripheral BDNF levels have been used as a biomarker in several clinical studies, since this neurotrophin is able to cross the blood-brain barrier in a bi-directional manner and seems to present a strong correlation with the central nervous system fluid levels. The patients with SZ usually adopts a sedentary lifestyle, which has been partly associated with the increase in obesity incidence rates, metabolic syndrome, type 2 diabetes and coronary heart disease. On the other hand, exercise, a non-invasive and low cost intervention, has been considered an important additional therapeutic option for this population, promoting benefits to physical and mental health. To our knowledge, few studies have been pointed out that the positive effects of exercise in SZ patients are mediated, at least in part, to enhanced levels of BDNF after training. However, these studies are focused on evaluating the effect of single bouts of exercise of chronic interventions, data concerning the short- and long-term exercise outcomes on BDNF are scarce. Therefore, this study aimed to evaluate the effect of a concurrent exercise protocol (CEP) on plasma BDNF levels of SZ patients in different time-points. Material and Methods: This study was approved by the Research Ethics Committee of the Centro Universitário Metodista do IPA (no 1.243.680/2015). The participants (n=15) were subbmited to the CEP during 90 days, 3 times a week for 60 minutes each session. In order to evaluate the short and long-term effects of exercise, blood samples were collected pre, 30, 60 and 90 days after the intervention began. Plasma BDNF levels were determined with the ELISA method, from Sigma-Aldrich commercial kit (catalog number RAB0026) according to manufacturer's instructions. Results: A remarkable increase on plasma BDNF levels at 90 days after training compared to baseline (p=0.006) and 30 days (p=0.007) values were observed. Conclusion: Our data are in agreement with several studies that show significant enhancement on BDNF levels in response to different exercise protocols in SZ individuals. We might suggest that BDNF upregulation after training in SZ patients acts in a dose-dependent manner, being more pronounced in response to chronic exposure. Acknowledgments: This work was supported by Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS)/Brazil. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=exercise" title="exercise">exercise</a>, <a href="https://publications.waset.org/abstracts/search?q=BDNF" title=" BDNF"> BDNF</a>, <a href="https://publications.waset.org/abstracts/search?q=schizophrenia" title=" schizophrenia"> schizophrenia</a>, <a href="https://publications.waset.org/abstracts/search?q=time-points" title=" time-points"> time-points</a> </p> <a href="https://publications.waset.org/abstracts/61528/temporal-profile-of-exercise-induced-changes-in-plasma-brain-derived-neurotrophic-factor-levels-of-schizophrenic-individuals" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/61528.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">252</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5251</span> Serum Neurotrophins in Different Metabolic Types of Obesity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Irina%20M.%20Kolesnikova">Irina M. Kolesnikova</a>, <a href="https://publications.waset.org/abstracts/search?q=Andrey%20M.%20Gaponov"> Andrey M. Gaponov</a>, <a href="https://publications.waset.org/abstracts/search?q=Sergey%20A.%20Roumiantsev"> Sergey A. Roumiantsev</a>, <a href="https://publications.waset.org/abstracts/search?q=Tatiana%20V.%20Grigoryeva"> Tatiana V. Grigoryeva</a>, <a href="https://publications.waset.org/abstracts/search?q=Alexander%20V.%20Laikov"> Alexander V. Laikov</a>, <a href="https://publications.waset.org/abstracts/search?q=Alexander%20V.%20Shestopalov"> Alexander V. Shestopalov</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background. Neuropathy is a common complication of obesity. In this regard, the content of neurotrophins in such patients is of particular interest. Neurotrophins are the proteins that regulate neuron survival and neuroplasticity and include brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). However, the risk of complications depends on the metabolic type of obesity. Metabolically unhealthy obesity (MUHO) is associated with a high risk of complications, while this is not the case with metabolically healthy obesity (MHO). Therefore, the aim of our work was to study the effect of the obesity metabolic type on serum neurotrophins levels. Patients, materials, methods. The study included 134 healthy donors and 104 obese patients. Depending on the metabolic type of obesity, the obese patients were divided into subgroups with MHO (n=40) and MUHO (n=55). In the blood serum, the concentration of BDNF and NGF was determined. In addition, the content of adipokines (leptin, asprosin, resistin, adiponectin), myokines (irisin, myostatin, osteocrin), indicators of carbohydrate, and lipid metabolism were measured. Correlation analysis revealed the relationship between the studied parameters. Results. We found that serum BDNF concentration was not different between obese patients and healthy donors, regardless of obesity metabolic type. At the same time, in obese patients, there was a decrease in serum NGF level versus control. A similar trend was characteristic of both MHO and MUHO. However, MUHO patients had a higher NGF level than MHO patients. The literature indicates that obesity is associated with an increase in the plasma concentration of NGF. It can be assumed that in obesity, there is a violation of NGF storage in platelets, which accelerates neurotrophin degradation. We found that BDNF concentration correlated with irisin levels in MUHO patients. Healthy donors had a weak association between NGF and VEGF levels. No such association was found in obese patients, but there was an association between NGF and leptin concentrations. In MHO, the concentration of NHF correlated with the content of leptin, irisin, osteocrin, insulin, and the HOMA-IR index. But in MUHO patients, we found only the relationship between NGF and adipokines (leptin, asprosin). It can be assumed that in patients with MHO, the replenishment of serum NGF occurs under the influence of muscle and adipose tissue. In the MUHO patients only the effect of adipose tissue on NGF was observed. Conclusion. Obesity, regardless of metabolic type, is associated with a decrease in serum NGF concentration. We showed that muscle and adipose tissues make a significant contribution to the serum NGF pool in the MHO patients. In MUHO there is no effect of muscle on the NGF level, but the effect of adipose tissue remains. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=neurotrophins" title="neurotrophins">neurotrophins</a>, <a href="https://publications.waset.org/abstracts/search?q=nerve%20growth%20factor" title=" nerve growth factor"> nerve growth factor</a>, <a href="https://publications.waset.org/abstracts/search?q=NGF" title=" NGF"> NGF</a>, <a href="https://publications.waset.org/abstracts/search?q=brain-derived%20neurotrophic%20factor" title=" brain-derived neurotrophic factor"> brain-derived neurotrophic factor</a>, <a href="https://publications.waset.org/abstracts/search?q=BDNF" title=" BDNF"> BDNF</a>, <a href="https://publications.waset.org/abstracts/search?q=obesity" title=" obesity"> obesity</a>, <a href="https://publications.waset.org/abstracts/search?q=metabolically%20healthy%20obesity" title=" metabolically healthy obesity"> metabolically healthy obesity</a>, <a href="https://publications.waset.org/abstracts/search?q=metabolically%20unhealthy%20obesity" title=" metabolically unhealthy obesity"> metabolically unhealthy obesity</a> </p> <a href="https://publications.waset.org/abstracts/145328/serum-neurotrophins-in-different-metabolic-types-of-obesity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/145328.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">100</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5250</span> Impact of Transgenic Adipose Derived Stem Cells in the Healing of Spinal Cord Injury of Dogs</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Imdad%20Ullah%20Khan">Imdad Ullah Khan</a>, <a href="https://publications.waset.org/abstracts/search?q=Yongseok%20Yoon"> Yongseok Yoon</a>, <a href="https://publications.waset.org/abstracts/search?q=Kyeung%20Uk%20Choi"> Kyeung Uk Choi</a>, <a href="https://publications.waset.org/abstracts/search?q=Kwang%20Rae%20Jo"> Kwang Rae Jo</a>, <a href="https://publications.waset.org/abstracts/search?q=Namyul%20Kim"> Namyul Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Eunbee%20Lee"> Eunbee Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Wan%20Hee%20Kim"> Wan Hee Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Oh-Kyeong%20Kweon"> Oh-Kyeong Kweon</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The primary spinal cord injury (SCI) causes mechanical damage to the neurons and blood vessels. It leads to secondary SCI, which activates multiple pathological pathways, which expand neuronal damage at the injury site. It is characterized by vascular disruption, ischemia, excitotoxicity, oxidation, inflammation, and apoptotic cell death. It causes nerve demyelination and disruption of axons, which perpetuate a loss of impulse conduction through the injured spinal cord. It also leads to the production of myelin inhibitory molecules, which with a concomitant formation of an astroglial scar, impede axonal regeneration. The pivotal role regarding the neuronal necrosis is played by oxidation and inflammation. During an early stage of spinal cord injury, there occurs an abundant expression of reactive oxygen species (ROS) due to defective mitochondrial metabolism and abundant migration of phagocytes (macrophages, neutrophils). ROS cause lipid peroxidation of the cell membrane, and cell death. Abundant migration of neutrophils, macrophages, and lymphocytes collectively produce pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1beta (IL-1β), matrix metalloproteinase, superoxide dismutase, and myeloperoxidases which synergize neuronal apoptosis. Therefore, it is crucial to control inflammation and oxidation injury to minimize the nerve cell death during secondary spinal cord injury. Therefore, in response to oxidation and inflammation, heme oxygenase-1 (HO-1) is induced by the resident cells to ameliorate the milieu. In the meanwhile, neurotrophic factors are induced to promote neuroregeneration. However, it seems that anti-stress enzyme (HO-1) and neurotrophic factor (BDNF) do not significantly combat the pathological events during secondary spinal cord injury. Therefore, optimum healing can be induced if anti-inflammatory and neurotrophic factors are administered in a higher amount through an exogenous source. During the first experiment, the inflammation and neuroregeneration were selectively targeted. HO-1 expressing MSCs (HO-1 MSCs) and BDNF expressing MSCs (BDNF MSC) were co-transplanted in one group (combination group) of dogs with subacute spinal cord injury to selectively control the expression of inflammatory cytokines by HO-1 and induce neuroregeneration by BDNF. We compared the combination group with the HO-1 MSCs group, BDNF MSCs group, and GFP MSCs group. We found that the combination group showed significant improvement in functional recovery. It showed increased expression of neural markers and growth-associated proteins (GAP-43) than in other groups, which depicts enhanced neuroregeneration/neural sparing due to reduced expression of pro-inflammatory cytokines such as TNF-alpha, IL-6 and COX-2; and increased expression of anti-inflammatory markers such as IL-10 and HO-1. Histopathological study revealed reduced intra-parenchymal fibrosis in the injured spinal cord segment in the combination group than in other groups. Thus it was concluded that selectively targeting the inflammation and neuronal growth with the combined use of HO-1 MSCs and BDNF MSCs more favorably promote healing of the SCI. HO-1 MSCs play a role in controlling the inflammation, which favors the BDNF induced neuroregeneration at the injured spinal cord segment of dogs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=HO-1%20MSCs" title="HO-1 MSCs">HO-1 MSCs</a>, <a href="https://publications.waset.org/abstracts/search?q=BDNF%20MSCs" title=" BDNF MSCs"> BDNF MSCs</a>, <a href="https://publications.waset.org/abstracts/search?q=neuroregeneration" title=" neuroregeneration"> neuroregeneration</a>, <a href="https://publications.waset.org/abstracts/search?q=inflammation" title=" inflammation"> inflammation</a>, <a href="https://publications.waset.org/abstracts/search?q=anti-inflammation" title=" anti-inflammation"> anti-inflammation</a>, <a href="https://publications.waset.org/abstracts/search?q=spinal%20cord%20injury" title=" spinal cord injury"> spinal cord injury</a>, <a href="https://publications.waset.org/abstracts/search?q=dogs" title=" dogs"> dogs</a> </p> <a href="https://publications.waset.org/abstracts/115125/impact-of-transgenic-adipose-derived-stem-cells-in-the-healing-of-spinal-cord-injury-of-dogs" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/115125.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">118</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5249</span> Antioxidant Effects of C-Phycocyanin on Oxidized Astrocyte in Brain Injury Using 2D and 3D Neural Nanofiber Tissue Model</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Seung%20Ju%20Yeon">Seung Ju Yeon</a>, <a href="https://publications.waset.org/abstracts/search?q=Seul%20Ki%20Min"> Seul Ki Min</a>, <a href="https://publications.waset.org/abstracts/search?q=Jun%20Sang%20%20Park"> Jun Sang Park</a>, <a href="https://publications.waset.org/abstracts/search?q=Yeo%20Seon%20Kwon"> Yeo Seon Kwon</a>, <a href="https://publications.waset.org/abstracts/search?q=Hoo%20Cheol%20Lee"> Hoo Cheol Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Hyun%20Jung%20Shim"> Hyun Jung Shim</a>, <a href="https://publications.waset.org/abstracts/search?q=Il-Doo%20Kim"> Il-Doo Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Ja%20Kyeong%20Lee"> Ja Kyeong Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Hwa%20Sung%20Shin"> Hwa Sung Shin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In brain injury, depleting oxidative stress is the most effective way to reduce the brain infarct size. C-phycocyanin (C-Pc) is a well-known antioxidant protein that has neuroprotective effects obtained from green microalgae. Astrocyte is glial cell that supports the nerve cell such as neuron, which account for a large portion of the brain. In brain injury, such as ischemia and reperfusion, astrocyte has an important rule that overcomes the oxidative stress and protect from brain reactive oxygen species (ROS) injury. However little is known about how C-Pc regulates the anti-oxidants effects of astrocyte. In this study, when the C-Pc was treated in oxidized astrocyte, we confirmed that inflammatory factors Interleukin-6 and Interleukin-3 were increased and antioxidants enzyme, Superoxide dismutase (SOD) and catalase was upregulated, and neurotrophic factors, brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) was alleviated. Also, it was confirmed to reduce infarct size of the brain in ischemia and reperfusion because C-Pc has anti-oxidant effects in middle cerebral artery occlusion (MCAO) animal model. These results show that C-Pc can help astrocytes lead neuroprotective activities in the oxidative stressed environment of the brain. In summary, the C-PC protects astrocytes from oxidative stress and has anti-oxidative, anti-inflammatory, neurotrophic effects under ischemic situations. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=c-phycocyanin" title="c-phycocyanin">c-phycocyanin</a>, <a href="https://publications.waset.org/abstracts/search?q=astrocyte" title=" astrocyte"> astrocyte</a>, <a href="https://publications.waset.org/abstracts/search?q=reactive%20oxygen%20species" title=" reactive oxygen species"> reactive oxygen species</a>, <a href="https://publications.waset.org/abstracts/search?q=ischemia%20and%20reperfusion" title=" ischemia and reperfusion"> ischemia and reperfusion</a>, <a href="https://publications.waset.org/abstracts/search?q=neuroprotective%20effect" title=" neuroprotective effect"> neuroprotective effect</a> </p> <a href="https://publications.waset.org/abstracts/50872/antioxidant-effects-of-c-phycocyanin-on-oxidized-astrocyte-in-brain-injury-using-2d-and-3d-neural-nanofiber-tissue-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50872.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">320</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5248</span> Differences in Cognitive Functioning over the Course of Chemotherapy in Patients Suffering from Multiple Myeloma and the Possibility to Predict Their Cognitive State on the Basis of Biological Factors</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Magdalena%20Bury-Kaminska">Magdalena Bury-Kaminska</a>, <a href="https://publications.waset.org/abstracts/search?q=Aneta%20Szudy-Szczyrek"> Aneta Szudy-Szczyrek</a>, <a href="https://publications.waset.org/abstracts/search?q=Aleksandra%20Nowaczynska"> Aleksandra Nowaczynska</a>, <a href="https://publications.waset.org/abstracts/search?q=Olga%20Jankowska-Lecka"> Olga Jankowska-Lecka</a>, <a href="https://publications.waset.org/abstracts/search?q=Marek%20Hus"> Marek Hus</a>, <a href="https://publications.waset.org/abstracts/search?q=Klaudia%20Kot"> Klaudia Kot</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: The aim of the research was to determine the changes in cognitive functioning in patients with plasma cell myeloma by comparing patients’ state before the treatment and during chemotherapy as well as to determine the biological factors that can be used to predict patients’ cognitive state. Methods: The patients underwent the research procedure twice: before chemotherapy and after 4-6 treatment cycles. A psychological test and measurement of the following biological variables were carried out: TNF-α (tumor necrosis factor), IL-6 (interleukin 6), IL-10 (interleukin 10), BDNF (brain-derived neurotrophic factor). The following research methods were implemented: the Montreal Cognitive Assessment (MoCA), Battery of Tests for Assessing Cognitive Functions PU1, experimental and clinical trials based on the Choynowski’s Memory Scale, Stroop Color-Word Interference Test (SCWT), depression measurement questionnaire. Results: The analysis of the research showed better cognitive functions of patients during chemotherapy in comparison to the phase before it. Moreover, neurotrophin BDNF allows to predict the level of selected cognitive functions (semantic fluency and execution control) already at the diagnosis stage. After 4-6 cycles, it is also possible to draw conclusions concerning the extent of working memory based on the level of BDNF. Cytokine TNF-α allows us to predict the level of letter fluency during anti-cancer treatment. Conclusions: It is possible to presume that BDNF has a protective influence on patients’ cognitive functions and working memory and that cytokine TNF-α co-occurs with a diminished execution control and better material grouping in terms of phonological fluency. Acknowledgment: This work was funded by the National Science Center in Poland [grant no. 2017/27/N/HS6/02057. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chemobrain" title="chemobrain">chemobrain</a>, <a href="https://publications.waset.org/abstracts/search?q=cognitive%20impairment" title=" cognitive impairment"> cognitive impairment</a>, <a href="https://publications.waset.org/abstracts/search?q=non%E2%88%92central%20nervous%20system%20cancers" title=" non−central nervous system cancers"> non−central nervous system cancers</a>, <a href="https://publications.waset.org/abstracts/search?q=hematologic%20diseases" title=" hematologic diseases"> hematologic diseases</a> </p> <a href="https://publications.waset.org/abstracts/133485/differences-in-cognitive-functioning-over-the-course-of-chemotherapy-in-patients-suffering-from-multiple-myeloma-and-the-possibility-to-predict-their-cognitive-state-on-the-basis-of-biological-factors" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/133485.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">152</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5247</span> Effect of Resistance Training on BDNF and Inflammatory Markers in Healthy Older Adults</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Obinna%20Afamefuna%20Echi">Obinna Afamefuna Echi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: The global increase in the elderly population is anticipated to reach significant levels by 2050, presenting extensive economic, social, and healthcare challenges. Age-related cognitive decline, alterations in brain anatomy, and systemic inflammation are profound concerns that diminish the quality of life and increase susceptibility to diseases like Alzheimer's and cardiovascular diseases. Resistance training is presently studied for its potential neuroprotective and anti-inflammatory benefits in older adults. Objectives: This study aimed to explore the effects of different resistance training modalities on neurotrophic factors, inflammatory markers, and cognitive functions in the elderly. Methods: A controlled trial was conducted with 60 male participants aged 60-75, assigned to either 12 weeks of high-intensity blood flow restriction training (BFRT), muscle damaging resistance training (MDRT), or a non-exercising control group. Cognitive function, neurotrophic factors such as BDNF, and inflammatory markers including IL-6 and TNF were measured before and after the intervention period. Setting: Participants were recruited from Kaunas, Lithuania, with sessions facilitated at the Lithuanian Sports University and health assessments conducted at the Lithuanian University of Health Sciences. Results: Preliminary data suggested did not show significant improvements in BDNF levels and cognitive functions in the BFRT and MDRT groups compared to controls. However, there was a notable reduction in inflammatory markers, indicating potential health benefits beyond cognitive enhancement. Conclusion: The incorporation of resistance training can be a strategic intervention to mitigate age-associated cognitive decline and systemic inflammation, thereby enhancing overall health and quality of life in older adults. The results advocate for wider adoption and further study of resistance training as a preventive measure in ageing populations. Funding: The Lithuanian Sports University, the Research Council of Lithuania and the Lithuanian University of Health Sciences. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ageing" title="ageing">ageing</a>, <a href="https://publications.waset.org/abstracts/search?q=resistance%20training" title=" resistance training"> resistance training</a>, <a href="https://publications.waset.org/abstracts/search?q=BDNF" title=" BDNF"> BDNF</a>, <a href="https://publications.waset.org/abstracts/search?q=cognitive%20function" title=" cognitive function"> cognitive function</a> </p> <a href="https://publications.waset.org/abstracts/185122/effect-of-resistance-training-on-bdnf-and-inflammatory-markers-in-healthy-older-adults" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/185122.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">46</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5246</span> The Effects of Continuous and Interval Aerobic Exercises with Moderate Intensity on Serum Levels of Glial Cell Line-Derived Neurotrophic Factor and Aerobic Capacity in Obese Children</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ali%20Golestani">Ali Golestani</a>, <a href="https://publications.waset.org/abstracts/search?q=Vahid%20Naseri"> Vahid Naseri</a>, <a href="https://publications.waset.org/abstracts/search?q=Hossein%20Taheri"> Hossein Taheri</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Recently, some of studies examined the effect of exercise on neurotrophic factors influencing the growth, protection, plasticity and function in central and peripheral nerve cells. The aim of this study was to investigate the effects of continuous and interval aerobic exercises with moderate intensity on serum levels of glial cell line-derived neurotrophic factor (GDNF) and aerobic capacity in obese children. 21 obese students with an average age of 13.6 ± 0.5 height 171 ± 5 and BMI 32 ± 1.2 were divided randomly to control, continuous aerobic and interval aerobic groups. Training protocol included continuous or interval aerobic exercises with moderate intensity 50-65%MHR, three times per week for 10 weeks. 48 hours before and after executing of protocol, blood samples were taken from the participants and their GDNF serum levels were measured by ELISA. Aerobic power was estimated using Shuttle-run test. T-test results indicated a small increase in their GDNF serum levels, which was not statistically significant (p =0.11). In addition, the results of ANOVA did not show any significant difference between continuous and interval aerobic training on the serum levels of their GDNF but their aerobic capacity significantly increased (p =0.012). Although continuous and interval aerobic exercise improves aerobic power in obese children, they had no significant effect on their serum levels of GDNF. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aerobic%20power" title="aerobic power">aerobic power</a>, <a href="https://publications.waset.org/abstracts/search?q=continuous%20aerobic%20training" title=" continuous aerobic training"> continuous aerobic training</a>, <a href="https://publications.waset.org/abstracts/search?q=glial%20cell%20line-derived%20neurotrophic%20factor%20%28GDNF%29" title=" glial cell line-derived neurotrophic factor (GDNF)"> glial cell line-derived neurotrophic factor (GDNF)</a>, <a href="https://publications.waset.org/abstracts/search?q=interval%20aerobic%20training" title=" interval aerobic training"> interval aerobic training</a>, <a href="https://publications.waset.org/abstracts/search?q=obese%20children" title=" obese children"> obese children</a> </p> <a href="https://publications.waset.org/abstracts/72856/the-effects-of-continuous-and-interval-aerobic-exercises-with-moderate-intensity-on-serum-levels-of-glial-cell-line-derived-neurotrophic-factor-and-aerobic-capacity-in-obese-children" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/72856.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">177</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5245</span> The Potential Role of Some Nutrients and Drugs in Providing Protection from Neurotoxicity Induced by Aluminium in Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Azza%20A.%20Ali">Azza A. Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Abeer%20I.%20Abd%20El-Fattah"> Abeer I. Abd El-Fattah</a>, <a href="https://publications.waset.org/abstracts/search?q=Shaimaa%20S.%20Hussein"> Shaimaa S. Hussein</a>, <a href="https://publications.waset.org/abstracts/search?q=Hanan%20A.%20Abd%20El-Samea"> Hanan A. Abd El-Samea</a>, <a href="https://publications.waset.org/abstracts/search?q=Karema%20Abu-Elfotuh"> Karema Abu-Elfotuh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Aluminium (Al) represents an environmental risk factor. Exposure to high levels of Al causes neurotoxic effects and different diseases. Vinpocetine is widely used to improve cognitive functions, it possesses memory-protective and memory-enhancing properties and has the ability to increase cerebral blood flow and glucose uptake. Cocoa bean represents a rich source of iron as well as a potent antioxidant. It can protect from the impact of free radicals, reduces stress as well as depression and promotes better memory and concentration. Wheatgrass is primarily used as a concentrated source of nutrients. It contains vitamins, minerals, carbohydrates, amino acids and possesses antioxidant and anti-inflammatory activities. Coenzyme Q10 (CoQ10) is an intracellular antioxidant and mitochondrial membrane stabilizer. It is effective in improving cognitive disorders and has been used as anti-aging. Zinc is a structural element of many proteins and signaling messenger that is released by neural activity at many central excitatory synapses. Objective: To study the role of some nutrients and drugs as Vinpocetine, Cocoa, Wheatgrass, CoQ10 and Zinc against neurotoxicity induced by Al in rats as well as to compare between their potency in providing protection. Methods: Seven groups of rats were used and received daily for three weeks AlCl3 (70 mg/kg, IP) for Al-toxicity model groups except for the control group which received saline. All groups of Al-toxicity model except one group (non-treated) were co-administered orally together with AlCl3 the following treatments; Vinpocetine (20mg/kg), Cocoa powder (24mg/kg), Wheat grass (100mg/kg), CoQ10 (200mg/kg) or Zinc (32mg/kg). Biochemical changes in the rat brain as acetyl cholinesterase (ACHE), Aβ, brain derived neurotrophic factor (BDNF), inflammatory mediators (TNF-α, IL-1β), oxidative parameters (MDA, SOD, TAC) were estimated for all groups besides histopathological examinations in different brain regions. Results: Neurotoxicity and neurodegenerations in the rat brain after three weeks of Al exposure were indicated by the significant increase in Aβ, ACHE, MDA, TNF-α, IL-1β, DNA fragmentation together with the significant decrease in SOD, TAC, BDNF and confirmed by the histopathological changes in the brain. On the other hand, co-administration of each of Vinpocetine, Cocoa, Wheatgrass, CoQ10 or Zinc together with AlCl3 provided protection against hazards of neurotoxicity and neurodegenerations induced by Al, their protection were indicated by the decrease in Aβ, ACHE, MDA, TNF-α, IL-1β, DNA fragmentation together with the increase in SOD, TAC, BDNF and confirmed by the histopathological examinations of different brain regions. Vinpocetine and Cocoa showed the most pronounced protection while Zinc provided the least protective effects than the other used nutrients and drugs. Conclusion: Different degrees of protection from neurotoxicity and neuronal degenerations induced by Al could be achieved through the co-administration of some nutrients and drugs during its exposure. Vinpocetine and Cocoa provided the most protection than Wheat grass, CoQ10 or Zinc which showed the least protective effects. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aluminum" title="aluminum">aluminum</a>, <a href="https://publications.waset.org/abstracts/search?q=neurotoxicity" title=" neurotoxicity"> neurotoxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=vinpocetine" title=" vinpocetine"> vinpocetine</a>, <a href="https://publications.waset.org/abstracts/search?q=cocoa" title=" cocoa"> cocoa</a>, <a href="https://publications.waset.org/abstracts/search?q=wheat%20grass" title=" wheat grass"> wheat grass</a>, <a href="https://publications.waset.org/abstracts/search?q=coenzyme%20Q10" title=" coenzyme Q10"> coenzyme Q10</a>, <a href="https://publications.waset.org/abstracts/search?q=Zinc" title=" Zinc"> Zinc</a>, <a href="https://publications.waset.org/abstracts/search?q=rats" title=" rats"> rats</a> </p> <a href="https://publications.waset.org/abstracts/62926/the-potential-role-of-some-nutrients-and-drugs-in-providing-protection-from-neurotoxicity-induced-by-aluminium-in-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/62926.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">249</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5244</span> Influence of Protein Malnutrition and Different Stressful Conditions on Aluminum-Induced Neurotoxicity in Rats: Focus on the Possible Protection Using Epigallocatechin-3-Gallate</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Azza%20A.%20Ali">Azza A. Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Asmaa%20Abdelaty"> Asmaa Abdelaty</a>, <a href="https://publications.waset.org/abstracts/search?q=Mona%20G.%20Khalil"> Mona G. Khalil</a>, <a href="https://publications.waset.org/abstracts/search?q=Mona%20M.%20Kamal"> Mona M. Kamal</a>, <a href="https://publications.waset.org/abstracts/search?q=Karema%20Abu-Elfotuh"> Karema Abu-Elfotuh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Aluminium (Al) is known as a neurotoxin environmental pollutant that can cause certain diseases as Dementia, Alzheimer's disease, and Parkinsonism. It is widely used in antacid drugs as well as in food additives and toothpaste. Stresses have been linked to cognitive impairment; Social isolation (SI) may exacerbate memory deficits while protein malnutrition (PM) increases oxidative damage in cortex, hippocampus and cerebellum. The risk of cognitive decline may be lower by maintaining social connections. Epigallocatechin-3-gallate (EGCG) is the most abundant catechin in green tea and has antioxidant, anti-inflammatory and anti-atherogenic effects as well as health-promoting effects in CNS. Objective: To study the influence of different stressful conditions as social isolation, electric shock (EC) and inadequate Nutritional condition as PM on neurotoxicity induced by Al in rats as well as to investigate the possible protective effect of EGCG in these stressful and PM conditions. Methods: Rats were divided into two major groups; protected group which was daily treated during three weeks of the experiment by EGCG (10 mg/kg, IP) or non-treated. Protected and non-protected groups included five subgroups as following: One normal control received saline and four Al toxicity groups injected daily for three weeks by ALCl3 (70 mg/kg, IP). One of them served as Al toxicity model, two groups subjected to different stresses either by isolation as mild stressful condition (SI-associated Al toxicity model) or by electric shock as high stressful condition (EC- associated Al toxicity model). The last was maintained on 10% casein diet (PM -associated Al toxicity model). Isolated rats were housed individually in cages covered with black plastic. Biochemical changes in the brain as acetyl cholinesterase (ACHE), Aβ, brain derived neurotrophic factor (BDNF), inflammatory mediators (TNF-α, IL-1β), oxidative parameters (MDA, SOD, TAC) were estimated for all groups. Histopathological changes in different brain regions were also evaluated. Results: Rats exposed to Al for three weeks showed brain neurotoxicity and neuronal degenerations. Both mild (SI) and high (EC) stressful conditions as well as inadequate nutrition (PM) enhanced Al-induced neurotoxicity and brain neuronal degenerations; the enhancement induced by stresses especially in its higher conditions (ES) was more pronounced than that of inadequate nutritional conditions (PM) as indicated by the significant increase in Aβ, ACHE, MDA, TNF-α, IL-1β together with the significant decrease in SOD, TAC, BDNF. On the other hand, EGCG showed more pronounced protection against hazards of Al in both stressful conditions (SI and EC) rather than in PM .The protective effects of EGCG were indicated by the significant decrease in Aβ, ACHE, MDA, TNF-α, IL-1β together with the increase in SOD, TAC, BDNF and confirmed by brain histopathological examinations. Conclusion: Neurotoxicity and brain neuronal degenerations induced by Al were more severe with stresses than with PM. EGCG can protect against Al-induced brain neuronal degenerations in all conditions. Consequently, administration of EGCG together with socialization as well as adequate protein nutrition is advised especially on excessive Al-exposure to avoid the severity of its neuronal toxicity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=environmental%20pollution" title="environmental pollution">environmental pollution</a>, <a href="https://publications.waset.org/abstracts/search?q=aluminum" title=" aluminum"> aluminum</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20isolation" title=" social isolation"> social isolation</a>, <a href="https://publications.waset.org/abstracts/search?q=protein%20malnutrition" title=" protein malnutrition"> protein malnutrition</a>, <a href="https://publications.waset.org/abstracts/search?q=neuronal%20degeneration" title=" neuronal degeneration"> neuronal degeneration</a>, <a href="https://publications.waset.org/abstracts/search?q=epigallocatechin-3-gallate" title=" epigallocatechin-3-gallate"> epigallocatechin-3-gallate</a>, <a href="https://publications.waset.org/abstracts/search?q=rats" title=" rats"> rats</a> </p> <a href="https://publications.waset.org/abstracts/62761/influence-of-protein-malnutrition-and-different-stressful-conditions-on-aluminum-induced-neurotoxicity-in-rats-focus-on-the-possible-protection-using-epigallocatechin-3-gallate" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/62761.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">391</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5243</span> Neuroprotective Effects of Dehydroepiandrosterone (DHEA) in Rat Model of Alzheimer’s Disease</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hanan%20F.%20Aly">Hanan F. Aly</a>, <a href="https://publications.waset.org/abstracts/search?q=Fateheya%20M.%20Metwally"> Fateheya M. Metwally</a>, <a href="https://publications.waset.org/abstracts/search?q=Hanaa%20H.%20Ahmed"> Hanaa H. Ahmed</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The current study is undertaken to elucidate a possible neuroprotective role of dehydroepiandrosterone (DHEA) against the development of Alzheimer’s disease in experimental rat model. Alzheimer’s disease was produced in young female ovariectomized rats by intraperitoneal administration of AlCl3 (4.2 mg/kg body weight) daily for 12 weeks. Half of these animals also received orally DHEA (250 mg/kg body weight, three times weekly) for 18 weeks. Control groups of animals received either DHAE alone, or no DHEA, or were not ovariectomized. After such treatment the animals were analyzed for oxidative stress biomarkers such as hydrogen peroxide, nitric oxide and malondialdehyde, total antioxidant capacity, reduced glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase and catalase activities, antiapoptotic marker Bcl-2 and brain derived neurotrophic factor. Also, brain cholinergic markers (acetylcholinesterase and acetylcholine) were determined. The results revealed significant increase in oxidative stress parameters associated with significant decrease in the antioxidant enzyme activities in Al-intoxicated ovariectomized rats. Significant depletion in brain Bcl-2 and brain-derived neurotrophic factor levels were also detected. Moreover, significant elevations in brain acetylcholinesterase activity accompanied with significant reduction in acetylcholine level were recorded. Significant amelioration in all investigated parameters was detected as a result of treatment of Al-intoxicated ovariectomized rats with DHEA. These results were confirmed by histological examination of brain sections. These results clearly indicate a neuroprotective effect of DHEA against Alzheimer’s disease. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alzheimer%E2%80%99s%20disease" title="Alzheimer’s disease">Alzheimer’s disease</a>, <a href="https://publications.waset.org/abstracts/search?q=oxidative%20stress" title=" oxidative stress"> oxidative stress</a>, <a href="https://publications.waset.org/abstracts/search?q=apoptosis" title=" apoptosis"> apoptosis</a>, <a href="https://publications.waset.org/abstracts/search?q=dehydroepiandrosterone" title=" dehydroepiandrosterone"> dehydroepiandrosterone</a> </p> <a href="https://publications.waset.org/abstracts/10530/neuroprotective-effects-of-dehydroepiandrosterone-dhea-in-rat-model-of-alzheimers-disease" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/10530.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">323</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5242</span> Microbioreactor System for Cell Behavior Analysis Focused on Nerve Tissue Engineering</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yusser%20Olgu%C3%ADn">Yusser Olguín</a>, <a href="https://publications.waset.org/abstracts/search?q=Diego%20Benavente"> Diego Benavente</a>, <a href="https://publications.waset.org/abstracts/search?q=Fernando%20Dorta"> Fernando Dorta</a>, <a href="https://publications.waset.org/abstracts/search?q=Nicole%20Orellana"> Nicole Orellana</a>, <a href="https://publications.waset.org/abstracts/search?q=Cristian%20Acevedo"> Cristian Acevedo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> One of the greatest challenges of tissue engineering is the generation of materials in which the highest possible number of conditions can be incorporated to stimulate the proliferation and differentiation of cells, which will be transformed together with the material into new functional tissue. In this sense, considering the properties of microfluidics and its relationship with cellular micro-environments, the possibility of controlling flow patterns and the ability to design diverse patterns in the chips, a microfluidic cell culture system can be established as a means for the evaluation of the effect of different parameters in a controlled and precise manner. Specifically in relation to the study and development of alternatives in peripheral nervous tissue engineering, it is necessary to consider different physical and chemical neurotrophic stimuli that promote cell growth and differentiation. Chemical stimuli include certain vitamins, glucocorticoids, gangliosides, and growth factors, while physical stimuli include topological stimuli, mechanical forces of the cellular environment and electrical stimulation. In this context, the present investigation shows the results of cell stimulation in a microbioreactor using electrical and chemical stimuli, where the differentiation of PC12 cells as a neuronal model is evidenced by neurite expression, dependent on the stimuli and their combination. The results were analysed with a multi-factor statistical approach, showing several relationships and dependencies between different parameters. Chip design, operating parameters and concentrations of neurotrophic chemical factors were found to be preponderant, based on the characteristics of the electrical stimuli. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=microfluidics" title="microfluidics">microfluidics</a>, <a href="https://publications.waset.org/abstracts/search?q=nerve%20tissue%20engineering" title=" nerve tissue engineering"> nerve tissue engineering</a>, <a href="https://publications.waset.org/abstracts/search?q=microbioreactor" title=" microbioreactor"> microbioreactor</a>, <a href="https://publications.waset.org/abstracts/search?q=electrical%20stimuli" title=" electrical stimuli"> electrical stimuli</a> </p> <a href="https://publications.waset.org/abstracts/154288/microbioreactor-system-for-cell-behavior-analysis-focused-on-nerve-tissue-engineering" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/154288.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">85</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5241</span> Neuropsychiatric Outcomes of Intensive Music Therapy in Stroke Rehabilitation A Premilitary Investigation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Honey%20Bryant">Honey Bryant</a>, <a href="https://publications.waset.org/abstracts/search?q=Elvina%20Chu"> Elvina Chu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Stroke is the leading cause of disability in adults in Canada and directly related to depression, anxiety, and sleep disorders; with an estimated annual cost of $50 billion in health care. Strokes not only impact the individual but society as a whole. Current stroke rehabilitation does not include Music Therapy, although it has success in clinical research in the use of stroke rehabilitation. This study examines the use of neurologic music therapy (NMT) in conjunction with stroke rehabilitation to improve sleep quality, reduce stress levels, and promote neurogenesis. Existing research on NMT in stroke is limited, which means any conclusive information gathered during this study will be significant. My novel hypotheses are a.) stroke patients will become less depressed and less anxious with improved sleep following NMT. b.) NMT will reduce stress levels and promote neurogenesis in stroke patients admitted for rehabilitation. c.) Beneficial effects of NMT will be sustained at least short-term following treatment. Participants were recruited from the in-patient stroke rehabilitation program at Providence Care Hospital in Kingston, Ontario, Canada. All participants-maintained stroke rehabilitation treatment as normal. The study was spilt into two groups, the first being Passive Music Listening (PML) and the second Neurologic Music Therapy (NMT). Each group underwent 10 sessions of intensive music therapy lasting 45 minutes for 10 consecutive days, excluding weekends. Psychiatric Assessments, Epworth Sleepiness Scale (ESS), Hospital Anxiety & Depression Rating Scale (HADS), and Music Engagement Questionnaire (MusEQ), were completed, followed by a general feedback interview. Physiological markers of stress were measured through blood pressure measurements and heart rate variability. Serum collections reviewed neurogenesis via Brain-derived neurotrophic factor (BDNF) and stress markers of cortisol levels. As this study is still on-going, a formal analysis of data has not been fully completed, although trends are following our hypotheses. A decrease in sleepiness and anxiety is seen upon the first cohort of PML. Feedback interviews have indicated most participants subjectively felt more relaxed and thought PML was useful in their recovery. If the hypothesis is supported, larger external funding which will allow for greater investigation of the use of NMT in stroke rehabilitation. As we know, NMT is not covered under Ontario Health Insurance Plan (OHIP), so there is limited scientific data surrounding its uses as a clinical tool. This research will provide detailed findings of the treatment of neuropsychiatric aspects of stroke. Concurrently, a passive music listening study is being designed to further review the use of PML in rehabilitation as well. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=music%20therapy" title="music therapy">music therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=psychotherapy" title=" psychotherapy"> psychotherapy</a>, <a href="https://publications.waset.org/abstracts/search?q=neurologic%20music%20therapy" title=" neurologic music therapy"> neurologic music therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=passive%20music%20listening" title=" passive music listening"> passive music listening</a>, <a href="https://publications.waset.org/abstracts/search?q=neuropsychiatry" title=" neuropsychiatry"> neuropsychiatry</a>, <a href="https://publications.waset.org/abstracts/search?q=counselling" title=" counselling"> counselling</a>, <a href="https://publications.waset.org/abstracts/search?q=behavioural" title=" behavioural"> behavioural</a>, <a href="https://publications.waset.org/abstracts/search?q=stroke" title=" stroke"> stroke</a>, <a href="https://publications.waset.org/abstracts/search?q=stroke%20rehabilitation" title=" stroke rehabilitation"> stroke rehabilitation</a>, <a href="https://publications.waset.org/abstracts/search?q=rehabilitation" title=" rehabilitation"> rehabilitation</a>, <a href="https://publications.waset.org/abstracts/search?q=neuroscience" title=" neuroscience"> neuroscience</a> </p> <a href="https://publications.waset.org/abstracts/157425/neuropsychiatric-outcomes-of-intensive-music-therapy-in-stroke-rehabilitation-a-premilitary-investigation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/157425.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">113</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5240</span> A Review on Bearing Capacity Factor Nγ of Foundations with Different Shapes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=R.%20Ziaie%20Moayed">R. Ziaie Moayed</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Taghvamanesh"> S. Taghvamanesh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> So far several methods by different researchers have been developed in order to calculate the bearing capacity factors of foundations and retaining walls. In this paper, the bearing capacity factor Ny (shape factor) for different types of foundation have been investigated. The formula for bearing capacity on c–φ–γ soil can still be expressed by Terzaghi’s equation except that the bearing capacity factor Ny depends on the surcharge ratio, and friction angle φ. Many empirical definitions have been used for measurement of the bearing capacity factors N <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bearing%20capacity" title="bearing capacity">bearing capacity</a>, <a href="https://publications.waset.org/abstracts/search?q=bearing%20capacity%20factor%20N%CE%B3" title=" bearing capacity factor Nγ"> bearing capacity factor Nγ</a>, <a href="https://publications.waset.org/abstracts/search?q=irregular%20foundations" title=" irregular foundations"> irregular foundations</a>, <a href="https://publications.waset.org/abstracts/search?q=shape%20factor" title=" shape factor"> shape factor</a> </p> <a href="https://publications.waset.org/abstracts/134905/a-review-on-bearing-capacity-factor-ngh-of-foundations-with-different-shapes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/134905.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">150</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5239</span> Response Reduction Factor for Earthquake Resistant Design of Special Moment Resisting Frames</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rohan%20V.%20Ambekar">Rohan V. Ambekar</a>, <a href="https://publications.waset.org/abstracts/search?q=Shrirang%20N.%20Tande"> Shrirang N. Tande</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study estimates the seismic response reduction factor (R) of reinforced concrete special moment resisting frame (SMRF) with and without shear wall using static nonlinear (pushover) analysis. Calculation of response reduction factor (R) is done as per the new formulation of response reduction factor (R) given by Applied Technology Council (ATC)-19 which is the product of strength factor (Rs), ductility factor (Rµ) and redundancy factor (RR). The analysis revealed that these three factors affect the actual value of response reduction factor (R) and therefore they must be taken into consideration while determining the appropriate response reduction factor to be used during the seismic design process. The actual values required for determination of response reduction factor (R) is worked out on the basis of pushover curve which is a plot of base shear verses roof displacement. Finally, the calculated values of response reduction factor (R) of reinforced concrete special moment resisting frame (SMRF) with and without shear wall are compared with the codal values. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=response%20reduction%20factor" title="response reduction factor">response reduction factor</a>, <a href="https://publications.waset.org/abstracts/search?q=ductility%20ratio" title=" ductility ratio"> ductility ratio</a>, <a href="https://publications.waset.org/abstracts/search?q=base%20shear" title=" base shear"> base shear</a>, <a href="https://publications.waset.org/abstracts/search?q=special%20moment%20resisting%20frames" title=" special moment resisting frames"> special moment resisting frames</a> </p> <a href="https://publications.waset.org/abstracts/1362/response-reduction-factor-for-earthquake-resistant-design-of-special-moment-resisting-frames" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1362.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">487</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5238</span> CIPP Evaluation of Online Broadcasting of Suan Dusit Rajabhat University</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Somkiat%20Korbuakaew">Somkiat Korbuakaew</a>, <a href="https://publications.waset.org/abstracts/search?q=Winai%20Mankhatitham"> Winai Mankhatitham</a>, <a href="https://publications.waset.org/abstracts/search?q=Anchan%20Chongcharoen"> Anchan Chongcharoen</a>, <a href="https://publications.waset.org/abstracts/search?q=Wichar%20Kunkum"> Wichar Kunkum</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This research’s objective is to evaluate the online broadcasting of Suan Dusit Rajabhat Univeristy by CIPP model. The evaluation was separated into 4 parts: context factor, input factor, process factor and product factor. Sample group in this research were 399 participants who were university’s executive, staff and students. Questionnaires and interview were the research tools. Data were analyzed by computer program. Statistics used here were percentage, mean, and standard deviation. Findings are as follows: 1. Context factor: The context factor here in this research was university’s executives, staff and students. The study shows that they would like to use online broadcasting to be the educational tool and IT development. 2. Input factor: The input factor was the modern IT equipment to create interesting teaching materials and develop education in general. 3. Process factor: The process factor in this study was the publication of the program that it should be promoted more among students and should be more objective. 4. Product factor: The product factor in this study was the purpose of the program that it expands the educational channel for students. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=evaluation" title="evaluation">evaluation</a>, <a href="https://publications.waset.org/abstracts/search?q=project" title=" project"> project</a>, <a href="https://publications.waset.org/abstracts/search?q=internet" title=" internet"> internet</a>, <a href="https://publications.waset.org/abstracts/search?q=online%20broadcasting" title=" online broadcasting"> online broadcasting</a> </p> <a href="https://publications.waset.org/abstracts/12013/cipp-evaluation-of-online-broadcasting-of-suan-dusit-rajabhat-university" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/12013.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">526</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5237</span> People’s Perception towards the ASEAN Economic Community (AEC)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nopadol%20Burananuth">Nopadol Burananuth</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The purposes of this research paper were to study the relationship between the economic factor and political factor, the relationship between political and economic factor and social factor, and the effects of economic factor, political factor, and social factor to the people’s perception about ASEAN Economic Community (AEC). A total of 400 samples were selected from four sub-districts from Arunyaprathet District, Srakaow Province. Data analysis method included multiple regression analysis. The findings revealed that political factor depended on trade cooperation, transportation cooperation, and communication cooperation. Social factor was depended on disaster protection, terrorism protection, and international relations. In addition, the people’s perception of the AEC depended on disaster perception, terrorism protection, international relations, transportation cooperation, communication cooperation, interdependence, and labor movement. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=economic%20factors" title="economic factors">economic factors</a>, <a href="https://publications.waset.org/abstracts/search?q=perception" title=" perception"> perception</a>, <a href="https://publications.waset.org/abstracts/search?q=political%20factors" title=" political factors"> political factors</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20factors" title=" social factors "> social factors </a> </p> <a href="https://publications.waset.org/abstracts/24648/peoples-perception-towards-the-asean-economic-community-aec" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24648.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">591</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5236</span> Positive Affect, Negative Affect, Organizational and Motivational Factor on the Acceptance of Big Data Technologies</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sook%20Ching%20Yee">Sook Ching Yee</a>, <a href="https://publications.waset.org/abstracts/search?q=Angela%20Siew%20Hoong%20Lee"> Angela Siew Hoong Lee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Big data technologies have become a trend to exploit business opportunities and provide valuable business insights through the analysis of big data. However, there are still many organizations that have yet to adopt big data technologies especially small and medium organizations (SME). This study uses the technology acceptance model (TAM) to look into several constructs in the TAM and other additional constructs which are positive affect, negative affect, organizational factor and motivational factor. The conceptual model proposed in the study will be tested on the relationship and influence of positive affect, negative affect, organizational factor and motivational factor towards the intention to use big data technologies to produce an outcome. Empirical research is used in this study by conducting a survey to collect data. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=big%20data%20technologies" title="big data technologies">big data technologies</a>, <a href="https://publications.waset.org/abstracts/search?q=motivational%20factor" title=" motivational factor"> motivational factor</a>, <a href="https://publications.waset.org/abstracts/search?q=negative%20affect" title=" negative affect"> negative affect</a>, <a href="https://publications.waset.org/abstracts/search?q=organizational%20factor" title=" organizational factor"> organizational factor</a>, <a href="https://publications.waset.org/abstracts/search?q=positive%20affect" title=" positive affect"> positive affect</a>, <a href="https://publications.waset.org/abstracts/search?q=technology%20acceptance%20model%20%28TAM%29" title=" technology acceptance model (TAM)"> technology acceptance model (TAM)</a> </p> <a href="https://publications.waset.org/abstracts/59434/positive-affect-negative-affect-organizational-and-motivational-factor-on-the-acceptance-of-big-data-technologies" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/59434.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">362</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5235</span> Influence of the Reliability Index on the Safety Factor of the Concrete Contribution to Shear Strength of HSC Beams</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ali%20Sagiroglu">Ali Sagiroglu</a>, <a href="https://publications.waset.org/abstracts/search?q=Sema%20Noyan%20Alacali"> Sema Noyan Alacali</a>, <a href="https://publications.waset.org/abstracts/search?q=Guray%20Arslan"> Guray Arslan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper presents a study on the influence of the safety factor in the concrete contribution to shear strength of high-strength concrete (HSC) beams according to TS500. In TS500, the contribution of concrete to shear strength is obtained by reducing diagonal cracking strength with a safety factor of 0.8. It was investigated that the coefficient of 0.8 considered in determining the contribution of concrete to the shear strength corresponds to which value of failure probability. Also, the changes in the reduction factor depending on different coefficients of variation of concrete were examined. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=reinforced%20concrete" title="reinforced concrete">reinforced concrete</a>, <a href="https://publications.waset.org/abstracts/search?q=beam" title=" beam"> beam</a>, <a href="https://publications.waset.org/abstracts/search?q=shear%20strength" title=" shear strength"> shear strength</a>, <a href="https://publications.waset.org/abstracts/search?q=failure%20probability" title=" failure probability"> failure probability</a>, <a href="https://publications.waset.org/abstracts/search?q=safety%20factor" title=" safety factor"> safety factor</a> </p> <a href="https://publications.waset.org/abstracts/22211/influence-of-the-reliability-index-on-the-safety-factor-of-the-concrete-contribution-to-shear-strength-of-hsc-beams" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/22211.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">830</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5234</span> Confirmatory Factor Analysis of Smartphone Addiction Inventory (SPAI) in the Yemeni Environment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohammed%20Al-Khadher">Mohammed Al-Khadher</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Currently, we are witnessing rapid advancements in the field of information and communications technology, forcing us, as psychologists, to combat the psychological and social effects of such developments. It also drives us to continually look for the development and preparation of measurement tools compatible with the changes brought about by the digital revolution. In this context, the current study aimed to identify the factor analysis of the Smartphone Addiction Inventory (SPAI) in the Republic of Yemen. The sample consisted of (1920) university students (1136 males and 784 females) who answered the inventory, and the data was analyzed using the statistical software (AMOS V25). The factor analysis results showed a goodness-of-fit of the data five-factor model with excellent indicators, as RMSEA-(.052), CFI-(.910), GFI-(.931), AGFI-(.915), TLI-(.897), NFI-(.895), RFI-(.880), and RMR-(.032). All within the ideal range to prove the model's fit of the scale’s factor analysis. The confirmatory factor analysis results showed factor loading in (4) items on (Time Spent), (4) items on (Compulsivity), (8) items on (Daily Life Interference), (5) items on (Craving), and (3) items on (Sleep interference); and all standard values of factor loading were statistically significant at the significance level (>.001). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=smartphone%20addiction%20inventory%20%28SPAI%29" title="smartphone addiction inventory (SPAI)">smartphone addiction inventory (SPAI)</a>, <a href="https://publications.waset.org/abstracts/search?q=confirmatory%20factor%20analysis%20%28CFA%29" title=" confirmatory factor analysis (CFA)"> confirmatory factor analysis (CFA)</a>, <a href="https://publications.waset.org/abstracts/search?q=yemeni%20students" title=" yemeni students"> yemeni students</a>, <a href="https://publications.waset.org/abstracts/search?q=people%20at%20risk%20of%20smartphone%20addiction" title=" people at risk of smartphone addiction"> people at risk of smartphone addiction</a> </p> <a href="https://publications.waset.org/abstracts/169823/confirmatory-factor-analysis-of-smartphone-addiction-inventory-spai-in-the-yemeni-environment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/169823.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">94</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5233</span> Bio-Functionalized Silk Nanofibers for Peripheral Nerve Regeneration</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kayla%20Belanger">Kayla Belanger</a>, <a href="https://publications.waset.org/abstracts/search?q=Pascale%20Vigneron"> Pascale Vigneron</a>, <a href="https://publications.waset.org/abstracts/search?q=Guy%20Schlatter"> Guy Schlatter</a>, <a href="https://publications.waset.org/abstracts/search?q=Bernard%20Devauchelle"> Bernard Devauchelle</a>, <a href="https://publications.waset.org/abstracts/search?q=Christophe%20Egles"> Christophe Egles</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A severe injury to a peripheral nerve leads to its degeneration and the loss of sensory and motor function. To this day, there still lacks a more effective alternative to the autograft which has long been considered the gold standard for nerve repair. In order to overcome the numerous drawbacks of the autograft, tissue engineered biomaterials may be effective alternatives. Silk fibroin is a favorable biomaterial due to its many advantageous properties such as its biocompatibility, its biodegradability, and its robust mechanical properties. In this study, bio-mimicking multi-channeled nerve guidance conduits made of aligned nanofibers achieved by electrospinning were functionalized with signaling biomolecules and were tested in vitro and in vivo for nerve regeneration support. Silk fibroin (SF) extracted directly from silkworm cocoons was put in solution at a concentration of 10wt%. Poly(ethylene oxide) (PEO) was added to the resulting SF solution to increase solution viscosity and the following three electrospinning solutions were made: (1) SF/PEO solution, (2) SF/PEO solution with nerve growth factor and ciliary neurotrophic factor, and (3) SF/PEO solution with nerve growth factor and neurotrophin-3. Each of these solutions was electrospun into a multi-layer architecture to obtain mechanically optimized aligned nanofibrous mats. For in vitro studies, aligned fibers were treated to induce β-sheet formation and thoroughly rinsed to eliminate presence of PEO. Each material was tested using rat embryo neuron cultures to evaluate neurite extension and the interaction with bio-functionalized or non-functionalized aligned fibers. For in vivo studies, the mats were rolled into 5mm long multi-, micro-channeled conduits then treated and thoroughly rinsed. The conduits were each subsequently implanted between a severed rat sciatic nerve. The effectiveness of nerve repair over a period of 8 months was extensively evaluated by cross-referencing electrophysiological, histological, and movement analysis results to comprehensively evaluate the progression of nerve repair. In vitro results show a more favorable interaction between growing neurons and bio-functionalized silk fibers compared to pure silk fibers. Neurites can also be seen having extended unidirectionally along the alignment of the nanofibers which confirms a guidance factor for the electrospun material. The in vivo study has produced positive results for the regeneration of the sciatic nerve over the length of the study, showing contrasts between the bio-functionalized material and the non-functionalized material along with comparisons to the experimental control. Nerve regeneration has been evaluated not only by histological analysis, but also by electrophysiological assessment and motion analysis of two separate natural movements. By studying these three components in parallel, the most comprehensive evaluation of nerve repair for the conduit designs can be made which can, therefore, more accurately depict their overall effectiveness. This work was supported by La Région Picardie and FEDER. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=electrospinning" title="electrospinning">electrospinning</a>, <a href="https://publications.waset.org/abstracts/search?q=nerve%20guidance%20conduit" title=" nerve guidance conduit"> nerve guidance conduit</a>, <a href="https://publications.waset.org/abstracts/search?q=peripheral%20nerve%20regeneration" title=" peripheral nerve regeneration"> peripheral nerve regeneration</a>, <a href="https://publications.waset.org/abstracts/search?q=silk%20fibroin" title=" silk fibroin"> silk fibroin</a> </p> <a href="https://publications.waset.org/abstracts/64271/bio-functionalized-silk-nanofibers-for-peripheral-nerve-regeneration" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/64271.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">246</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5232</span> A High Quality Factor Filter Based on Quasi- Periodic Photonic Structure</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hamed%20Alipour-Banaei">Hamed Alipour-Banaei</a>, <a href="https://publications.waset.org/abstracts/search?q=Farhad%20Mehdizadeh"> Farhad Mehdizadeh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We report the design and characterization of ultra high quality factor filter based on one-dimensional photonic-crystal Thue-Morse sequence structure. The behavior of aperiodic array of photonic crystal structure is numerically investigated and we show that by changing the angle of incident wave, desired wavelengths could be tuned and a tunable filter is realized. Also it is shown that high quality factor filter be achieved in the telecommunication window around 1550 nm, with a device based on Thue-Morse structure. Simulation results show that the proposed structure has a quality factor more than 100000 and it is suitable for DWDM communication applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Thue-Morse" title="Thue-Morse">Thue-Morse</a>, <a href="https://publications.waset.org/abstracts/search?q=filter" title=" filter"> filter</a>, <a href="https://publications.waset.org/abstracts/search?q=quality%20factor" title=" quality factor"> quality factor</a>, <a href="https://publications.waset.org/abstracts/search?q=photonic" title=" photonic"> photonic</a> </p> <a href="https://publications.waset.org/abstracts/31621/a-high-quality-factor-filter-based-on-quasi-periodic-photonic-structure" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/31621.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">572</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5231</span> Analysis of Factors Affecting Public Awareness in Paying Zakat</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Roikhan%20Mochamad%20Aziz">Roikhan Mochamad Aziz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study aims to analze the interdependence of several variables simultaneously in order to simplify the form of the relationship between some of the variables studied a number of factors less than the variable studied which means it can also describe the data structure of a research. Based 100 respondents from the public, such as the people of South Tangerang, this study used factor analysis tool. The results of this study indicate that the studied variables being formed into nine factors, namely faith factors, community factors, factors of social care, confidence factor, factor income, educational factors, self-satisfaction factors, factors work, and knowledge factor. Total variance of the 9 factors is 67,30% means that all nine of these factors are factors that can contribute too paying zakat of muzakki consciousness of 67,30% while the remaining 32,70% is supported by other factors outside the 9 factors. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=zakat" title="zakat">zakat</a>, <a href="https://publications.waset.org/abstracts/search?q=analysis%20factor" title=" analysis factor"> analysis factor</a>, <a href="https://publications.waset.org/abstracts/search?q=faith" title=" faith"> faith</a>, <a href="https://publications.waset.org/abstracts/search?q=education" title=" education"> education</a>, <a href="https://publications.waset.org/abstracts/search?q=knowledge" title=" knowledge"> knowledge</a> </p> <a href="https://publications.waset.org/abstracts/65581/analysis-of-factors-affecting-public-awareness-in-paying-zakat" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/65581.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">280</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5230</span> Forecasting Electricity Spot Price with Generalized Long Memory Modeling: Wavelet and Neural Network</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Souhir%20Ben%20Amor">Souhir Ben Amor</a>, <a href="https://publications.waset.org/abstracts/search?q=Heni%20Boubaker"> Heni Boubaker</a>, <a href="https://publications.waset.org/abstracts/search?q=Lotfi%20Belkacem"> Lotfi Belkacem</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This aims of this paper is to forecast the electricity spot prices. First, we focus on modeling the conditional mean of the series so we adopt a generalized fractional -factor Gegenbauer process (k-factor GARMA). Secondly, the residual from the -factor GARMA model has used as a proxy for the conditional variance; these residuals were predicted using two different approaches. In the first approach, a local linear wavelet neural network model (LLWNN) has developed to predict the conditional variance using the Back Propagation learning algorithms. In the second approach, the Gegenbauer generalized autoregressive conditional heteroscedasticity process (G-GARCH) has adopted, and the parameters of the k-factor GARMA-G-GARCH model has estimated using the wavelet methodology based on the discrete wavelet packet transform (DWPT) approach. The empirical results have shown that the k-factor GARMA-G-GARCH model outperform the hybrid k-factor GARMA-LLWNN model, and find it is more appropriate for forecasts. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=electricity%20price" title="electricity price">electricity price</a>, <a href="https://publications.waset.org/abstracts/search?q=k-factor%20GARMA" title=" k-factor GARMA"> k-factor GARMA</a>, <a href="https://publications.waset.org/abstracts/search?q=LLWNN" title=" LLWNN"> LLWNN</a>, <a href="https://publications.waset.org/abstracts/search?q=G-GARCH" title=" G-GARCH"> G-GARCH</a>, <a href="https://publications.waset.org/abstracts/search?q=forecasting" title=" forecasting"> forecasting</a> </p> <a href="https://publications.waset.org/abstracts/75361/forecasting-electricity-spot-price-with-generalized-long-memory-modeling-wavelet-and-neural-network" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75361.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">231</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5229</span> Mind Your Product-Market Strategy on Selecting Marketing Inputs: An Uncertainty Approach in Indian Context</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Susmita%20Ghosh">Susmita Ghosh</a>, <a href="https://publications.waset.org/abstracts/search?q=Bhaskar%20Bhowmick"> Bhaskar Bhowmick</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Market is an important factor for start-ups to look into during decision-making in product development and related areas. Emerging country markets are more uncertain in terms of information availability and institutional supports. The literature review of market uncertainty reveals the need for identifying factors representing the market uncertainty. This paper identifies factors for market uncertainty using Exploratory Factor Analysis (EFA) and confirms the number of factor retention using an alternative factor retention criterion, ‘Parallel Analysis’. 500 entrepreneurs, engaged in start-ups from all over India participated in the study. This paper concludes with the factor structure of ‘market uncertainty’ having dimensions of uncertainty in industry orientation, uncertainty in customer orientation and uncertainty in marketing orientation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=uncertainty" title="uncertainty">uncertainty</a>, <a href="https://publications.waset.org/abstracts/search?q=market" title=" market"> market</a>, <a href="https://publications.waset.org/abstracts/search?q=orientation" title=" orientation"> orientation</a>, <a href="https://publications.waset.org/abstracts/search?q=competitor" title=" competitor"> competitor</a>, <a href="https://publications.waset.org/abstracts/search?q=demand" title=" demand "> demand </a> </p> <a href="https://publications.waset.org/abstracts/24877/mind-your-product-market-strategy-on-selecting-marketing-inputs-an-uncertainty-approach-in-indian-context" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24877.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">590</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=Brain-Derived%20Neurotrophic%20Factor%20%28BDNF%29&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=Brain-Derived%20Neurotrophic%20Factor%20%28BDNF%29&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=Brain-Derived%20Neurotrophic%20Factor%20%28BDNF%29&page=4">4</a></li> <li class="page-item"><a class="page-link" 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