CINXE.COM

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experts</h2> <p>Written by our in-house experts and external collaborators, the following range of posters have been presented at scientific meetings, and provide an informative summary of key areas of research. We invite you to request your copy today.</p> <hr> <div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/posters/fullsize/659701.jpg" data-toggle="lightbox" data-title="Developing Degraders Scientific Posters" data-footer="<a href='/literature/literature-request/p659701' rel='nofollow' title='Request PDF of the Developing Degraders Scientific Posters'>Request PDF</a> today"><img src="https://resources.tocris.com/images/literature/posters/regular/659701.jpg" alt="Developing Degraders Scientific Posters" class="img-fluid"></a> </div> <h3>Developing Degraders</h3> <h4>Principles and Perspectives on Design and Chemical Space</h4> <p class="small">Maple, H <em>et al.</em></p> This poster describes the generation of a database of Degraders (PROTACs<sup>®</sup>) from the literature. The Degraders were profiled according to the constituent ligands, linker type, linker length and physicochemical properties and this information was used to establish a set of guidelines for the design and synthesis of cell-permeable Degrader molecules. Presented at the 20th SCI/RSC Medicinal Chemistry Symposium 2019, Cambridge, UK.</p> <p><em>PROTAC<sup>®</sup> is a registered trademark of Arvinas Operations, Inc., and is used under license.</em> <ul class="lit_buttons"> <li><a class="btn btn-quinary request-pdf" href="/literature/literature-request/p659701" rel="nofollow" title="Request PDF of the Developing Degraders Scientific Posters">Request PDF<div class="lit_request_pdf"></div></a></li> </ul> </div></div><div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/posters/fullsize/660812.jpg" data-toggle="lightbox" data-title="Enabling Research By Provision of Chemical Tools Scientific Posters" data-footer="<a href='/literature/literature-request/p660812' rel='nofollow' title='Request PDF of the Enabling Research By Provision of Chemical Tools Scientific Posters'>Request PDF</a> today"><img src="https://resources.tocris.com/images/literature/posters/regular/660812.jpg" alt="Enabling Research By Provision of Chemical Tools Scientific Posters" class="img-fluid"></a> </div> <h3>Enabling Research By Provision of Chemical Tools</h3> <h4>Developing New Chemical Tools for Biological Research</h4> <p class="small">Maple, H <em>et al.</em></p> The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA. <ul class="lit_buttons"> <li><a class="btn btn-quinary request-pdf" href="/literature/literature-request/p660812" rel="nofollow" title="Request PDF of the Enabling Research By Provision of Chemical Tools Scientific Posters">Request PDF<div class="lit_request_pdf"></div></a></li> </ul> </div></div><div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/posters/fullsize/766834.jpg" data-toggle="lightbox" data-title="Novel Live-cell and Fixable Mitochondrial Probes Scientific Poster" data-footer="<a href='/literature/literature-request/p766834' rel='nofollow' title='Request PDF of the Novel Live-cell and Fixable Mitochondrial Probes Scientific Poster'>Request PDF</a> today"><img loading="lazy" src="https://resources.tocris.com/images/literature/posters/regular/766834.jpg" alt="Novel Live-cell and Fixable Mitochondrial Probes Scientific Poster" class="img-fluid"></a> </div> <h3>Novel Live-cell and Fixable Mitochondrial Probes</h3> <h4>MitoBrilliant™ Dyes For Flow Cytometry and Imaging</h4> <p class="small">Wood, P <em>et al.</em></p> Fluorescent probes that accumulate in the mitochondria are useful tools to explore mitochondrial function and cell health. This poster reports the development inhouse and characterization of novel fluorescent probes, known as MitoBrilliant that specifically localize to mitochondria due to mitochondrial membrane potential. The probes are suitable for live or fixed cell staining. The data demonstrate the specificity and enhanced properties of our MitoBrilliant dyes and their use in a range of applications. This poster was presented at CYTO 2022, June 2022, Philadelphia, USA. <ul class="lit_buttons"> <li><a class="btn btn-quinary request-pdf" href="/literature/literature-request/p766834" rel="nofollow" title="Request PDF of the Novel Live-cell and Fixable Mitochondrial Probes Scientific Poster">Request PDF<div class="lit_request_pdf"></div></a></li> </ul> </div></div><div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/posters/fullsize/634527.jpg" data-toggle="lightbox" data-title="Targeted Protein Degradation Scientific Poster" data-footer="<a href='/literature/literature-request/p634527' rel='nofollow' title='Request PDF of the Targeted Protein Degradation Scientific Poster'>Request PDF</a> today"><img loading="lazy" src="https://resources.tocris.com/images/literature/posters/regular/634527.jpg" alt="Targeted Protein Degradation Scientific Poster" class="img-fluid"></a> </div> <h3>Targeted Protein Degradation</h3> <h4>Generating a Chemical Toolbox to Support PROTAC R&D</h4> <p class="small">Maple, H <em>et al.</em></p> <p>Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia</p> <ul class="lit_buttons"> <li><a class="btn btn-quinary request-pdf" href="/literature/literature-request/p634527" rel="nofollow" title="Request PDF of the Targeted Protein Degradation Scientific Poster">Request PDF<div class="lit_request_pdf"></div></a></li> </ul> </div></div><div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/posters/fullsize/766777.jpg" data-toggle="lightbox" data-title="Validating Targets for TPD Using dTAG Scientific Poster" data-footer="<a href='/literature/literature-request/p766777' rel='nofollow' title='Request PDF of the Validating Targets for TPD Using dTAG Scientific Poster'>Request PDF</a> today"><img loading="lazy" src="https://resources.tocris.com/images/literature/posters/regular/766777.jpg" alt="Validating Targets for TPD Using dTAG Scientific Poster" class="img-fluid"></a> </div> <h3>Validating Targets for TPD Using dTAG</h3> <h4>A Comprehensive Workflow Solution</h4> <p class="small">Amrollahi, P <em>et al.</em></p> The dTAG platform offers a generalizable strategy to degrade, in principle, any intracellular protein of interest (POI) and is a useful strategy for exploration and validation of targets. This poster presents a workflow solution for target validation, from custom TAG knock-in cell-lines for your POI, different dTAG Degraders to knockdown you POI, to automated assays for protein degradation using Simple Western<sup>TM</sup> instruments. Data are also presented on the use of an antibody that recognizes the TAG domain (FKBP12<sup>F36V</sup>) for detection of degradation. Presented at TPD Europe, March 2022, London, UK. <ul class="lit_buttons"> <li><a class="btn btn-quinary request-pdf" href="/literature/literature-request/p766777" rel="nofollow" title="Request PDF of the Validating Targets for TPD Using dTAG Scientific Poster">Request PDF<div class="lit_request_pdf"></div></a></li> </ul> </div></div> </div> <div id="sidebar" class="col-xs-12 col-sm-4 col-md-3 col-lg-3 col-xl-3"> <div class="distributor_region"></div> </div> </section> <section id="block-block-16" class="block block-block clearfix">  <div class="embeddedServiceInvitation" id="snapins_invite" aria-live="assertive" role="dialog" aria-atomic="true" style="display: none;"> <div class="embeddedServiceInvitationHeader" aria-labelledby="snapins_titletext" aria-describedby="snapins_bodytext" style="height:48px;"> <img id="embeddedServiceAvatar" /> <span class="embeddedServiceTitleText" id="snapins_titletext">Need help?</span> <button type="button" id="closeInvite" 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