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Cell Orchestration Platform Delivery

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id="content" class="block-wrapper" role="main"><section id="block_2601f72b17bf6091bcfb5d4cd3d6e2f8" class="block simple-hero"><div class="container"><div class="row align-items-top"><div class="col-md-12"><h1 class="simple-hero__heading">Delivering Solutions to Customers</h1><p class="simple-hero__text">A future challenge within the Cell and Gene Therapy sector is likely to be the divergence and variety of therapy classes and the resulting differences in the processes that are needed in their supply chain. OCELLOS has been developed with this in mind, the system is driven by a client specific configuration that our team of experts work on perfecting throughout the ‘discovery’ phase of the project. This involves going through processes in detail to create the workflows, notifications and rules that proactively guide stakeholders through the therapy journey, providing them with the right information to make decisions and creating a robust chain of identity, chain of custody and audit trail.<br /> <br /> The TrakCel approach allows our team to deliver each cell orchestration platform that they configure, to meet the client&#8217;s specific needs quickly and efficiently. We operate a client-led approach meaning that you can deploy in a single project, or in phases as required. Read snippets from our latest projects below.</p></div></div></div></section><div id="block_4d71963a7393f42cdef54e72de11dd24" class="archive-wrapper block--grey"><div class="container"><div class="row"><div class="col-12 text-center"><h2 class="archive-leadershipteam__title">Recent Cell Orchestration Platform Solutions</h2></div><div class="col-md-4 mb-4"><div class="modal-wrapper team-card-wrapper" data-toggle="modal" data-target="#member00"><div class="team-card image-slider-component__slide"><div class="team-card__top"><div class="image-on-circle"><div class="halo-orange-blue"></div> <img decoding="async" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://trakcel.com/wp-content/uploads/2022/06/Multiple-cell-selection-concept-01-150x150.png" alt="Allogeneic therapy cell orchestration - multiple collection" class="team-card__image lazyload"><noscript><img decoding="async" src="https://trakcel.com/wp-content/uploads/2022/06/Multiple-cell-selection-concept-01-150x150.png" alt="Allogeneic therapy cell orchestration - multiple collection" class="team-card__image lazyload"></noscript></div></div><div class="team-card__bottom"><h3 class="team-card__heading">Allogeneic Therapy Cell Orchestration | Cell Selection Cycles</h3><h4 class="team-card__subheading">Partial Match Allogeneic Therapy</h4><p class="team-card__text">Integrated cell orchestration platform that could manage the multiple cycles of cell selection process. The therapy journey also had stages that required multiple users to undertake the same task independently to compare and verify the outcome.</p><div class="team-card__read-more"><p>Read more</p></div></div></div><div class="modal fade" id="member00" tabindex="-1" role="dialog" aria-labelledby="leadershipteam-modalTitle" aria-hidden="true"><div class="modal-dialog modal-lg modal-dialog-centered" role="document"><div class="modal-content leadershipteam-modal"><div class="modal-header"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"> <span aria-hidden="true">&times;</span> </button><div class="author-page__author-image"> <img decoding="async" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://trakcel.com/wp-content/themes/trakcel/assets/images/orange-blue-halo.svg" alt="" class="image-halo-border__halo lazyload"><noscript><img decoding="async" src="https://trakcel.com/wp-content/themes/trakcel/assets/images/orange-blue-halo.svg" alt="" class="image-halo-border__halo lazyload"></noscript><div class="image-halo-border__person lazy" role="img" alt="Profile image of A" style="background-image:url(https://trakcel.com/wp-content/uploads/2022/06/Multiple-cell-selection-concept-01.png)"></div></div><h3 class="leadershipteam-modal__title">Allogeneic Therapy Cell Orchestration | Cell Selection Cycles</h3><h4 class="leadershipteam-modal__subtitle">Partial Match Allogeneic Therapy</h4></div><div class="modal-body"><p><span data-contrast="auto">The client is a US based developer of both Autologous and Allogeneic cell therapies targeting cancers and autoimmune conditions. The therapy in question is a partial match allogeneic cytotoxic T Lymphocyte (CTL) therapy in late-stage clinical trial. </span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}"> </span></p><h3><span data-contrast="none">Challenge</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559738&quot;:40,&quot;335559739&quot;:0,&quot;335559740&quot;:259}"> </span></h3><p><span data-contrast="auto">The client required an integrated allogeneic therapy cell orchestration platform that could follow their therapy through the multiple cycles of cell selection process. The therapy journey also had stages that required multiple users to undertake the same task independently to compare and verify the outcome.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}"> </span></p><h3><span data-contrast="none">Solution</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559738&quot;:40,&quot;335559739&quot;:0,&quot;335559740&quot;:259}"> </span></h3><p><span data-contrast="auto">TrakCel scoped a solution that maintains the chain of identity and chain of custody of both cells and data over the course of multiple donor cell matching cycles if required. The process uses a workflow to determine whether to trigger a new selection cycle, or progress to the next stage of the therapy delivery based on the outcome of a decision made by two, independent stakeholders in the process and then verified by the treating physician. This means that the number of cycles that each therapy requires can differ from patient to patient, but all are included in the audit history that is recorded by the OCELLOS platform.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}"> </span></p><p><span data-contrast="auto">The customer’s process above required the creation of bespoke user profiles within the system to allow decision information to be collected ‘blind’ to avoid bias within the key processes that drive the therapy journey. In order for two independently generated decisions to be collected separately so that they can be verified against each other. Keeping this information separate</span><span data-contrast="auto">,</span><span data-contrast="auto"> whilst using the same pool of expert decision makers involved creating bespoke rules in the configuration of the orchestration solution that could govern which data fields were visible to each user. Customized user input screens were designed for each stage of the process to ensure that all the information required for patient safety and the audit trail is still captured but redacted at key points of the process.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}"> </span></p><div class="team-card__read-more"><a href="https://trakcel.com/contact-demo-page/">Book Demo</a></div><p>&nbsp;</p></div></div></div></div></div></div><div class="col-md-4 mb-4"><div class="modal-wrapper team-card-wrapper" data-toggle="modal" data-target="#member01"><div class="team-card image-slider-component__slide"><div class="team-card__top"><div class="image-on-circle"><div class="halo-orange-blue"></div> <img decoding="async" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://trakcel.com/wp-content/uploads/2022/06/multiple-Indication-concept-01-150x150.png" alt="multiple indication therapy icon" class="team-card__image lazyload"><noscript><img decoding="async" src="https://trakcel.com/wp-content/uploads/2022/06/multiple-Indication-concept-01-150x150.png" alt="multiple indication therapy icon" class="team-card__image lazyload"></noscript></div></div><div class="team-card__bottom"><h3 class="team-card__heading">Multiple Indication Therapy</h3><h4 class="team-card__subheading">Autologous CAR-T</h4><p class="team-card__text">Chain of Identity platform for an early clinical trial therapy with two indications that could be deployed quickly. Patient sets needed to be separated as the collaborators (such as healthcare and apheresis centres differed) presenting a data privacy concern.</p><div class="team-card__read-more"><p>Read more</p></div></div></div><div class="modal fade" id="member01" tabindex="-1" role="dialog" aria-labelledby="leadershipteam-modalTitle" aria-hidden="true"><div class="modal-dialog modal-lg modal-dialog-centered" role="document"><div class="modal-content leadershipteam-modal"><div class="modal-header"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"> <span aria-hidden="true">&times;</span> </button><div class="author-page__author-image"> <img decoding="async" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://trakcel.com/wp-content/themes/trakcel/assets/images/orange-blue-halo.svg" alt="" class="image-halo-border__halo lazyload"><noscript><img decoding="async" src="https://trakcel.com/wp-content/themes/trakcel/assets/images/orange-blue-halo.svg" alt="" class="image-halo-border__halo lazyload"></noscript><div class="image-halo-border__person lazy" role="img" alt="Profile image of m" style="background-image:url(https://trakcel.com/wp-content/uploads/2022/06/multiple-Indication-concept-01.png)"></div></div><h3 class="leadershipteam-modal__title">Multiple Indication Therapy</h3><h4 class="leadershipteam-modal__subtitle">Autologous CAR-T</h4></div><div class="modal-body"><p><span data-contrast="auto">The Client is a US based therapy developer of autologous CAR-T and TIL therapies targeting solid tumors. This project was a multiple indication therapy orchestration of an autologous CAR-T therapy targeting solid tumors and is in Phase 1 clinical trials. </span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}"> </span></p><h3><span data-contrast="none">Challenge</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559738&quot;:40,&quot;335559739&quot;:0,&quot;335559740&quot;:259}"> </span></h3><p><span class="TextRun SCXW184458837 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW184458837 BCX0">The client wanted a quick and simple deployment suitable for an </span><span class="NormalTextRun SCXW184458837 BCX0">early clinical trial of</span><span class="NormalTextRun SCXW184458837 BCX0"> a single therapy with two separate and therefore separate patient sets. The therapy process for each indication was </span><span class="NormalTextRun SCXW184458837 BCX0">the same other than patient sets needing to be separated, and c</span><span class="NormalTextRun SCXW184458837 BCX0">ollaborators (e.g., healthcare and apheresis centres) differing</span><span class="NormalTextRun SCXW184458837 BCX0">. This presented a data privacy driver as well as a need to facilitate the therapy journey whist maintaining Chain of Identity and </span><span class="NormalTextRun SCXW184458837 BCX0">visibility for the therapy sponsor.</span></span><span class="EOP SCXW184458837 BCX0" data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}"> </span></p><h3><span data-contrast="none">Solution</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559738&quot;:40,&quot;335559739&quot;:0,&quot;335559740&quot;:259}"> </span></h3><p><span data-contrast="auto">The OCELLOS therapy switcher was an option for the management of the two therapy processes, but as it is designed to accommodate therapies with different classes or processes, the TrakCel team looked for different solution that was more suited to the similarity of the therapy journeys.  As a result, a simpler solution was designed, allowing a simple drop-down selection of indication at patient enrolment to guide the data-flow to the relevant users and stakeholders for the rest of the therapy journey. This methodology allows the patient populations to be treated entirely separately, even when they are being dealt with by common stakeholders whilst minimizing the cost of ownership of the solution and the validation burden on the client over the course of the phased roll out that was planned.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}"> </span></p><p><span data-contrast="auto">Being an early phase clinical therapy, deploying a solution that would be easy for users to adopt as well as cost effective for the client to add features, integrations and functionality as the therapy progresses through the later phases of clinical trials through to commercialization was critical to the client. The client has a number of other therapies in their pipeline that are approaching clinical trial and requires a platform that can manage all of these in the future to minimize the training and maintenance. The OCELLOS solution that has been scoped for the client has been developed in partnership with the client to ensure that it is set up to facilitate planned progression with client led milestones for key phases being mapped out to match the client’s development schedule. </span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}"> </span></p><div class="team-card__read-more"><a href="https://trakcel.com/contact-demo-page/">Book Demo</a></div><p>&nbsp;</p></div></div></div></div></div></div><div class="col-md-4 mb-4"><div class="modal-wrapper team-card-wrapper" data-toggle="modal" data-target="#member02"><div class="team-card image-slider-component__slide"><div class="team-card__top"><div class="image-on-circle"><div class="halo-orange-blue"></div> <img decoding="async" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://trakcel.com/wp-content/uploads/2022/06/Multiple-assessment-concept-01-150x150.png" alt="Repeated Patient Screenings - icon" class="team-card__image lazyload"><noscript><img decoding="async" src="https://trakcel.com/wp-content/uploads/2022/06/Multiple-assessment-concept-01-150x150.png" alt="Repeated Patient Screenings - icon" class="team-card__image lazyload"></noscript></div></div><div class="team-card__bottom"><h3 class="team-card__heading">Gene Therapy Orchestration | Repeated Patient Screenings</h3><h4 class="team-card__subheading">Ex-vivo Autologous Gene Therapy</h4><p class="team-card__text">A chain of identity solution was required to be able to track and record where the same patient had been screened on multiple occasions. The chain of custody needed to incorporate storage time warnings for cryo-preserved cells.</p><div class="team-card__read-more"><p>Read more</p></div></div></div><div class="modal fade" id="member02" tabindex="-1" role="dialog" aria-labelledby="leadershipteam-modalTitle" aria-hidden="true"><div class="modal-dialog modal-lg modal-dialog-centered" role="document"><div class="modal-content leadershipteam-modal"><div class="modal-header"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"> <span aria-hidden="true">&times;</span> </button><div class="author-page__author-image"> <img decoding="async" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://trakcel.com/wp-content/themes/trakcel/assets/images/orange-blue-halo.svg" alt="" class="image-halo-border__halo lazyload"><noscript><img decoding="async" src="https://trakcel.com/wp-content/themes/trakcel/assets/images/orange-blue-halo.svg" alt="" class="image-halo-border__halo lazyload"></noscript><div class="image-halo-border__person lazy" role="img" alt="Profile image of R" style="background-image:url(https://trakcel.com/wp-content/uploads/2022/06/Multiple-assessment-concept-01.png)"></div></div><h3 class="leadershipteam-modal__title">Gene Therapy Orchestration | Repeated Patient Screenings</h3><h4 class="leadershipteam-modal__subtitle">Ex-vivo Autologous Gene Therapy</h4></div><div class="modal-body"><p><span data-contrast="auto">The client is a US based therapy developer with a pipeline of CAR-T aimed at various cancers and ex-vivo gene therapy products aimed rare paediatric </span>genetic <span data-contrast="auto">immunodeficiency. The project was an ex-vivo, autologous gene therapy orchestration. </span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}"> </span></p><h3><span data-contrast="none">Challenge</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559738&quot;:40,&quot;335559739&quot;:0,&quot;335559740&quot;:259}"> </span></h3><p><span data-contrast="auto">The therapy process meant that some patients were screened multiple times ahead of being accepted for treatment and there needed to be some way of tying these different screenings together for patient record purposes. The process also involved periods of cell storage during which the location of the cells needed to be proactively recorded as those stored in cryogenic shippers had to be processed within the accepted charged life of the shipper.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}"> </span></p><h3><span data-contrast="none">Solution</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559738&quot;:40,&quot;335559739&quot;:0,&quot;335559740&quot;:259}"> </span></h3><p><span data-contrast="auto">The OCELLOS solution was configured to allow multiple screening events against a common unique patient id by adding an incrementing suffix to the id that indicated the screening event that the patient journey started from. This allows relevant users to report where a patient had been screened before, how many times and when; any of which could drive a workflow to alter the enrolment process or later stages of the therapy journey if required. </span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}"> </span></p><p><span data-contrast="auto">This information then feeds into the audit trail for the full therapy journey and can be used with additional information imported documentation to support reviews or audit requests as required.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}"> </span></p><p><span data-contrast="auto">Pro-active management of cell location was achieved by configuring workflows to trigger email  notifications to the stakeholders to prompt action once stated parameters were met. For example, cryo-preserved materials are routinely stored within cryo-shippers for a period of time before being mover to the next step of the process. The charge life of the shippers is critical. As such, the OCELLOS system uses this as critical information triggering a custom notification to the manufacturing stakeholder well in advance of potential failure.</span></p><div class="team-card__read-more"><a href="https://trakcel.com/contact-demo-page/">Book Demo</a></div><p>&nbsp;</p></div></div></div></div></div></div><div class="col-md-4 mb-4"><div class="modal-wrapper team-card-wrapper" data-toggle="modal" data-target="#member03"><div class="team-card image-slider-component__slide"><div class="team-card__top"><div class="image-on-circle"><div class="halo-orange-blue"></div> <img decoding="async" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://trakcel.com/wp-content/uploads/2022/06/Multiple-collection-concept-01-01-150x150.png" alt="multiple collection" class="team-card__image lazyload"><noscript><img decoding="async" src="https://trakcel.com/wp-content/uploads/2022/06/Multiple-collection-concept-01-01-150x150.png" alt="multiple collection" class="team-card__image lazyload"></noscript></div></div><div class="team-card__bottom"><h3 class="team-card__heading">Orchestrating Autologous Gene | Multiple Collection Cycles</h3><h4 class="team-card__subheading">Autologous Gene Editing</h4><p class="team-card__text">Multiple apheresis collections from each patient with a more complex chain of identity and chain of custody solution as multiple lots are combined into a single patient infusion. Healthcare locations tied to specific apheresis centres.</p><div class="team-card__read-more"><p>Read more</p></div></div></div><div class="modal fade" id="member03" tabindex="-1" role="dialog" aria-labelledby="leadershipteam-modalTitle" aria-hidden="true"><div class="modal-dialog modal-lg modal-dialog-centered" role="document"><div class="modal-content leadershipteam-modal"><div class="modal-header"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"> <span aria-hidden="true">&times;</span> </button><div class="author-page__author-image"> <img decoding="async" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://trakcel.com/wp-content/themes/trakcel/assets/images/orange-blue-halo.svg" alt="" class="image-halo-border__halo lazyload"><noscript><img decoding="async" src="https://trakcel.com/wp-content/themes/trakcel/assets/images/orange-blue-halo.svg" alt="" class="image-halo-border__halo lazyload"></noscript><div class="image-halo-border__person lazy" role="img" alt="Profile image of m" style="background-image:url(https://trakcel.com/wp-content/uploads/2022/06/Multiple-collection-concept-01-01.png)"></div></div><h3 class="leadershipteam-modal__title">Orchestrating Autologous Gene | Multiple Collection Cycles</h3><h4 class="leadershipteam-modal__subtitle">Autologous Gene Editing</h4></div><div class="modal-body"><p>The client is a US based therapy developer with a broad pipeline of therapies from preclinical to pivotal/commercial. The system deployed is orchestrating autologous gene editing therapies targeting genetic blood disorders that are readying for commercialization.</p><h3>Challenge</h3><p>This therapy often requires multiple apheresis collections from each patient in order to generate sufficient cell volumes to progress manufacturing, what is more, these repeated collections needed to be treated independently of each other but run in tandem with a second cell collection process. This created both a more complex chain of identity and chain of custody solution as multiple patient samples must be managed to produce a variety of lots that are finally combined into a single patient infusion. The structure of the organisation meant matching each healthcare location with a regional ‘cluster’ of apheresis centres that in some cases were shared by other healthcare centres. Ensuring patients were assigned correctly to these centres was an important part of the process.</p><h3>Solution</h3><p>The OCELLOS solution was configured to accept and track multiple apheresis collections over a period by assigning a unique identifying number. This apheresis id then relates back to the patient identifier and then the resulting lot number, recording information such as cell counts as those samples progress through the manufacturing process. The system then tracks these individual lots for each patient until they are at the point of being combined into a shipment to form a final dose. This means that all the relevant information relating to the transit, manufacturing and storage of the various lots is available as part of the audit trail for the patient.</p><p>The scheduling element of the system also helps healthcare providers offer clarity to patients who are undergoing therapy, giving them better visibility of the schedule for the multiple apheresis collections that are required.</p><p>The TrakCel team configured OCELLOS to match the commercial relationships between the prescribing healthcare centre and their corresponding apheresis centres so that healthcare users only see the correct centres when booking client appointments. To facilitate ease of use for all users in the supply chain, the dashboard that the apheresis centre users see then consolidates the patients that they are dealing with, even where they come from multiple treatment centres. This means that each patient journey is processed in the same way for users, with OCELLOS ensuring that the correct parameters are in place for the next step of the journey.</p><div class="team-card__read-more"><a href="https://trakcel.com/contact-demo-page/">Book Demo</a></div><p>&nbsp;</p></div></div></div></div></div></div><div class="col-md-4 mb-4"><div class="modal-wrapper team-card-wrapper" data-toggle="modal" data-target="#member04"><div class="team-card image-slider-component__slide"><div class="team-card__top"><div class="image-on-circle"><div class="halo-orange-blue"></div> <img decoding="async" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://trakcel.com/wp-content/uploads/2022/09/Geographic-Diversity-01-01-150x150.png" alt="Geographic Diversity icon" class="team-card__image lazyload"><noscript><img decoding="async" src="https://trakcel.com/wp-content/uploads/2022/09/Geographic-Diversity-01-01-150x150.png" alt="Geographic Diversity icon" class="team-card__image lazyload"></noscript></div></div><div class="team-card__bottom"><h3 class="team-card__heading">Geographically Diverse</h3><h4 class="team-card__subheading">Autologous CAR-T</h4><p class="team-card__text">The client needed a solution that could manage a therapy that was approaching commercialization and would help teams to manage accurate scheduling in a supply network where transportation times were variable.</p><div class="team-card__read-more"><p>Read more</p></div></div></div><div class="modal fade" id="member04" tabindex="-1" role="dialog" aria-labelledby="leadershipteam-modalTitle" aria-hidden="true"><div class="modal-dialog modal-lg modal-dialog-centered" role="document"><div class="modal-content leadershipteam-modal"><div class="modal-header"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"> <span aria-hidden="true">&times;</span> </button><div class="author-page__author-image"> <img decoding="async" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://trakcel.com/wp-content/themes/trakcel/assets/images/orange-blue-halo.svg" alt="" class="image-halo-border__halo lazyload"><noscript><img decoding="async" src="https://trakcel.com/wp-content/themes/trakcel/assets/images/orange-blue-halo.svg" alt="" class="image-halo-border__halo lazyload"></noscript><div class="image-halo-border__person lazy" role="img" alt="Profile image of G" style="background-image:url(https://trakcel.com/wp-content/uploads/2022/09/Geographic-Diversity-01-01.png)"></div></div><h3 class="leadershipteam-modal__title">Geographically Diverse</h3><h4 class="leadershipteam-modal__subtitle">Autologous CAR-T</h4></div><div class="modal-body"><p>The client is a UK based therapy developer with a pivotal phase autologous CAR-T therapy targeting adult Acute Lymphoblastic Leukemia.</p><h3>Challenge</h3><p>The client required a solution that could manage commercial scale up for this pivotal phase therapy aimed to target adult B-ALL which they estimate impacts over 8000 patients annually in the US and EU. This meant considering geographically diverse patient populations with the language, time zone and logistics challenges that increasing volumes of therapies over a wide geography presented.</p><h3>Solution</h3><p>A key part of the process was in managing the differences in the shipping times of materials between the leukapheresis centres and manufacturers and then back out to treatment centres at the end of the manufacturing process. This was overcome by setting up relationships in the OCELLOS system between the various sites that specifically indicated where they were physically located in relation to the other sites that they might need to ship to. Once set, the OCELLOS system could use this information to vary the scheduling of the manufacturing slots and other time dependent elements of the therapy journey later in the supply chain.</p><p>This means that when scheduling the treatment plan for a patient the healthcare provider can see location specific calculations on the therapy timeline. This both helps to provide a better patient experience but also allows for more precise scheduling and reduces the chance that the process will stray from the most efficient path as a result of unrealistic timescales.</p><div class="team-card__read-more"><a href="https://trakcel.com/contact-demo-page/">Book Demo</a></div><p>&nbsp;</p></div></div></div></div></div></div></div></div></div><section id="block_d8c22a4671ab9ed917340ad413127e3a" class="block simple-hero"><div class="container"><div class="row align-items-top"><div class="col-md-6"><h1 class="simple-hero__heading">Find Out How TrakCel Could Help You</h1><p class="simple-hero__text">The fast evolving nature of the science that powers the advanced therapy and regenerative medicine industries means that the supply chain processes that support the delivery of these treatments from the first-in-human trials, all the way through to commercial approval are constantly becoming more complex.<br /> <br /> The unique way that the second generation cell orchestration platform OCELLOS by TrakCel uses configuration to quickly and effectively map these processes without the need to invest time, resource and risk in customizing the underlying code or structure of the system, ensures t can meet specific customer requirements and continue to evolve over the lifetime of the therapy.<br /> <br /> For more information on how OCELLOS could support your therapy, why not get in touch with the team and book a customized demo?</p><div class="img-text-card__buttons"> <a href="https://trakcel.com/book-ocellos-demo/" class="link-btn img-text-card__link-btn" target=""> Book a Demo <span class="arrow-wrapper"> <span aria-hidden="true" class="link-btn-chevron"> <span class="link-btn-chevron-arrow"></span> </span> </span> </a></div></div><div class="col-md-6 text-center"><div class="image-on-circle"> <img decoding="async" src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" 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for='input_17_18'>Email</label><div class='ginput_container'><input name='input_18' id='input_17_18' type='text' value='' autocomplete='new-password'/></div><div class='gfield_description' id='gfield_description_17_18'>This field is for validation purposes and should be left unchanged.</div></div></div></div><div class='gform-footer gform_footer top_label'> <input type='submit' id='gform_submit_button_17' class='gform_button button' onclick='gform.submission.handleButtonClick(this)' value='Sign up &rarr;' /> <input type='hidden' name='gform_ajax' value='form_id=17&amp;title=&amp;description=&amp;tabindex=0&amp;theme=gravity-theme' /> <input type='hidden' class='gform_hidden' name='gform_submission_method' data-js='gform_submission_method_17' value='iframe' /> <input type='hidden' class='gform_hidden' name='is_submit_17' value='1' /> <input type='hidden' class='gform_hidden' name='gform_submit' value='17' /> <input type='hidden' class='gform_hidden' name='gform_unique_id' value='' /> 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name='gform_ajax_frame_17' id='gform_ajax_frame_17' title='This iframe contains the logic required to handle Ajax powered Gravity Forms.'></iframe> <script type="text/javascript"> /* <![CDATA[ */ gform.initializeOnLoaded( function() {gformInitSpinner( 17, 'https://trakcel.com/wp-content/plugins/gravityforms/images/spinner.svg', true );jQuery('#gform_ajax_frame_17').on('load',function(){var contents = jQuery(this).contents().find('*').html();var is_postback = contents.indexOf('GF_AJAX_POSTBACK') >= 0;if(!is_postback){return;}var form_content = jQuery(this).contents().find('#gform_wrapper_17');var is_confirmation = jQuery(this).contents().find('#gform_confirmation_wrapper_17').length > 0;var is_redirect = contents.indexOf('gformRedirect(){') >= 0;var is_form = form_content.length > 0 && ! is_redirect && ! is_confirmation;var mt = parseInt(jQuery('html').css('margin-top'), 10) + parseInt(jQuery('body').css('margin-top'), 10) + 100;if(is_form){form_content.find('form').css('opacity', 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rel="nofollow noreferrer" target="_blank"> <span class="sr-only">Twitter</span> <img class="fa-svg-icon" src="https://trakcel.com/wp-content/themes/trakcel/assets/images/fa-x-twitter.svg" alt="X-twitter" width="22" height="22" /> </a></li><li class="social-list__item"> <a href="https://www.youtube.com/channel/UCeovK0jhNtXZ8kV1Z7lZC0A" class="social-list__link" rel="nofollow noreferrer" target="_blank"> <span class="sr-only">YouTube</span> <img class="fa-svg-icon" src="https://trakcel.com/wp-content/themes/trakcel/assets/images/fa-youtube.svg" alt="LinkedIn" width="22" height="22" /> </a></li></ul></div><div class="col-6 col-lg-12 d-flex align-items-center justify-content-end justify-content-lg-start"><p class="footer__copyright">&copy; TrakCel 2024</p></div></div></div></div> <!-- socials and signup end --></div> <!-- container end --></footer> <!-- footer end --></div><!--wrapper--> <script type="text/javascript" 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