<!DOCTYPE HTML PUBLIC "-//W3C//Dtd HTML 4.01 Transitional//EN"> <html> <head>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-9H47X4K6P6"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-9H47X4K6P6'); </script> <link href="/css/style.css" type="text/css" rel="stylesheet">  </head> <div id="header"> <body bgcolor="#ffffff" leftmargin=0 topmargin=0 marginwidth="0" marginheight="0" >  <table width="915" cellpadding=0 cellspacing=0> <tr><td colspan=8 > <table cellpadding=2 cellspacing=0 width="100%" border=0> <TR> <td rowspan=2 colspan=8 valign=middle align="left"> <DIV style=" padding: 5px 5px 5px 5px;vertical-align: middle;"> <DIV style="float:left; display:table-cell; vertical-align: middle; text-align: center; padding: 10px 20px 5px 5px;"> <a href="/" target="_top"><img src="/images/logos/Panther_logo.jpg" ></a> </DIV> <p style="overflow:hidden;font-size:14px">The mission of the PANTHER knowledgebase is to support biomedical and other research by providing<BR> <b>comprehensive information about the evolution of protein-coding gene families</b>, particularly<BR> protein phylogeny, function and genetic variation impacting that function. <a href="/about.jsp">Learn more</a></p> </DIV> </td> </TR> </table> </td> </tr> <TR> <TD align = "left"><div><b>PANTHER19.0 Released. <a href="/news/news20240620.jsp"> Click</a> for more details.</b></div></TD> </TR> <TR><TD> </TD></TR> <TR> <TD colspan=8 bgcolor="#F0F2F5" valign=middle align="left" > <form name="quicksearch" method=GET onSubmit="javascript:submitQuickSearch();"> <input type="hidden" name="searchType" value="basic"> <input type="hidden" name="fieldName" value="all"> <input type="hidden" name="organism" value="all"> <table align="left" border="0" cellspacing="0" cellpadding="0" height="100%"> <tr> <td nowrap height=25><input type="text" name="fieldValue" placeholder="search keyword" size=25 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Orthologs</A>  </TD> <TD width=5><img src="/images/header/divider.gif" border="0"></TD> <TD class="subHeader" align="center">  <A href="/panther/">Family & HMMs</A>  </TD> <TD width=5><img src="/images/header/divider.gif" border="0"></TD> <TD class="subHeader" align="center">  <A href="/pathway/">Pathway</A>  </TD> <TD width=5><img src="/images/header/divider.gif" border="0"></TD> <TD class="subHeader" align="center">  <A href="/panther/ontologies.jsp?">Ontologies</A>  </TD> <TD width=5><img src="/images/header/divider.gif" border="0"></TD>  </TR> </TABLE> </TD> </TR> <TR> <TD height=1 colspan=8 bgcolor="#B8C6D8"><img height=1 src="/images/spacer.gif"></TD> </TR> </table> <table width="915" cellpadding=0 cellspacing=0 width="100%" border=0> <TR> <TD> </TD>   <TD align = "right" class="formLabel"> Current Release: <a href="/news/news20240620.jsp"><b>PANTHER 19.0</a></b>  |  <b><a href="/panther/index.jsp">15,683</a></b> family phylogenetic trees  |  <b><a href="/panther/summaryStats.jsp">144</a></b> species  |  <a href="/news/news20240620.jsp">News</a>  <br><A href="/servlet/GenomeFunctionChartServlet?chartType=1&listType=1&annotType=5&species=Homo sapiens">Whole genome function views</A>   </TD> </TR> </table> </div>    <div id="mainBody"> <div style = "margin: 15px;"> <span class="formtitle">Click the sub-menu above to enter the data page for each specific PANTHER data type.</span> <BR><BR> Refer to the <a href="/dataFlow.jsp"> dataflow document</a> for details about PANTHER data. <br><BR> <b>PANTHER Data at a glance:</b> <br><BR> <dt><img src="/images/dots_three.gif" align="top"> <b>Version 19.0 released 2024-06-20</b> <br><BR> <dt><img src="/images/dots_three.gif" align="top"> <b>Gene (Reference Proteome 2023_03 and 2023_05 release)</b></dt> <ul> <li type="disc">144 genomes</li> <li type="disc">2692827 total genes</li> <li type="disc">2017190 genes in PANTHER families with phylogenetic trees, multiple sequence alignments and HMMs</li> </ul> <br> <dt><img src="/images/dots_three.gif" align="top"> <b>Family (PANTHER 19.0, released 2024-06-20)</b></dt> <ul> <li type="disc">15683 PANTHER families</li> <li type="disc">128012 subfamilies</li> </ul> <br> <dt><img src="/images/dots_three.gif" align="top"> <b>Pathways</b></dt> <ul> <li type="disc">PANTHER Pathway 3.6.8, released 2024-06-20</li> <ul> <li type="disc">177 pathways</li> <li type="disc">3092 pathway components</li> <li type="disc">50128 sequence associated to pathways</li> <li type="disc">5996 references captured for the pathways</li> </ul> <BR> <li type="disc"><a href="http://reactomerelease.oicr.on.ca/">Reactome</a> (from Reactome database version 86, released 2023-09-07)</li> <ul> <li>22462 total terms</li> </ul> </ul> <br> <dt><img src="/images/dots_three.gif" align="top"> <b>Ontologies</b></dt> <ul> <li type="disc"><a href="/panther/goSlim.jsp">PANTHER GO slim</a> (version 19.0, based on GO release 2024-01-17, released 2024-06-20)</li> <ul> <li>3348 total terms</li> <li>2200 biological process terms</li> <li>537 cellular component terms</li> <li>611 molecular function terms</li> </ul> <li type="disc">PANTHER Protein Class (version 19.0, released 2024-06-20)</li> <ul> <li>210 total terms</li> </ul> </ul> <BR> <ul> <li type="disc"><a href="http://geneontology.org/">Gene Ontology</a> (from GO database released 2024-11-03, DOI: 10.5281/zenodo.14083199)</li> <ul> <li>43978 total terms</li> <li>11224 molecular function terms</li> <li>28505 biological process terms</li> <li>4249 cellular component terms</li> </ul> </ul> <BR> </div>  </div>   <div id="footer"> <table width="915" cellpadding="0" cellspacing="0" border="0" width="100%"> <tr> <td align="center"> <span class="legal"> <DIV style=" padding: 0px 5px 0px 5px;text-align:center;vertical-align:middle;"> <a href="/about.jsp">About</a>   |   <a href="/releaseInfo.jsp">Release Information</a>   |   <a href="/feedback.jsp">Contact Us</a>   |   <a 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