Adaptive Immunity Markers

<!DOCTYPE html> <html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#"> <head> <meta charset="utf-8" /> <noscript><style>form.antibot * :not(.antibot-message) { display: none !important; }</style> </noscript><meta name="applicable-device" content="pc,mobile" /> <meta name="description" content="View our adaptive immunity markers including naïve T cells (CD45RA, CCR7), effector T cells (CD69, CD45RO), memory T cells (CD62L, CD95), T cell cytokines (IL-4, IL-17), B cells (CD9, CD19)." /> <meta name="keywords" content="Adaptive Immunity Markers" /> <link rel="canonical" href="https://www.bio-techne.com/research-areas/immunology/adaptive-immunity" /> <meta property="og:site_name" content="Bio-Techne" /> <meta property="og:type" content="website" /> <meta property="og:url" content="https://www.bio-techne.com/research-areas/immunology/adaptive-immunity" /> <meta property="og:image" content="https://resources.bio-techne.com/bio-techne-assets/images/brands/bio-techne-og.png" /> <meta name="published-date" content="1686122826" /> <meta name="brand" content="Novus Biologicals" /> <meta name="research-area" content="Immunology" /> <meta name="product-category" content="Antibodies" /> <meta name="revision-date" content="1729085718" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <script type="application/ld+json">{ "@context": "https://schema.org", "@graph": [ { "@type": "WebPage", "@id": "https://www.bio-techne.com/research-areas/immunology/adaptive-immunity", "breadcrumb": { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bio-techne.com/" }, { "@type": "ListItem", "position": 2, "name": "Research Areas", "item": "https://www.bio-techne.com/research-areas" }, { "@type": "ListItem", "position": 3, "name": "Immunology Research", "item": "https://www.bio-techne.com/research-areas/immunology" } ] } } ] }</script> <meta http-equiv="x-dns-prefetch-control" content="on" /> <meta http-equiv="x-ua-compatible" content="ie=edge" /> <link rel="alternate" hreflang="en" href="https://www.bio-techne.com/research-areas/immunology/adaptive-immunity" /> <link rel="alternate" hreflang="zh-hans" href="https://www.bio-techne.com/cn/research-areas/immunology/adaptive-immunity" /> <link rel="icon" href="/themes/custom/bio_techne_global/favicon.ico" type="image/vnd.microsoft.icon" /> <link rel="preconnect" href="https://resources.bio-techne.com" /> <link rel="preconnect" href="https://resources.tocris.com" /> <link rel="preconnect" href="https://i.icomoon.io" /> <link rel="preconnect" href="https://cdn.icomoon.io" /> <link rel="dns-prefetch" href="https://connect.facebook.net" /> <link rel="dns-prefetch" href="https://resources.bio-techne.com" /> <link rel="dns-prefetch" href="https://snap.licdn.com" /> <link rel="dns-prefetch" href="https://www.google-analytics.com" /> <link rel="dns-prefetch" href="https://munchkin.marketo.net" /> <link rel="dns-prefetch" href="https://resources.tocris.com" /> <link rel="dns-prefetch" href="https://i.icomoon.io" /> <link rel="dns-prefetch" href="https://cdn.icomoon.io" /> <title>Adaptive Immunity Markers | Bio-Techne</title> <link rel="stylesheet" media="all" href="/sites/default/files/css/css_656_2vqy1Km2MYNBaMfnvrWzlHUsrQzYL6gRawV6hgo.css?delta=0&language=en&theme=bio_techne_global&include=eJxNzmFyhDAIBeALJeZIDImsUjFkIWnH21fXtttfb_hmeGDkTavzJ0HHLAQPlk6W7M_jy4Mf3mlPGZ1CZoVOZa0Ei2hGSXdE74dwXcLHc5AdMBi8ca1n30-GoroxQdXODy7YWWu6Lf63mEXLFhoaLoZt9TTbaCjTW6ZR28jCvtIcBA8dHfJgmc9r_UuLCjiVqyw003mUfs5oZU13QMbrnX0nKwTPwWVTu5Z_Lb5ter3zDT02d0M" /> <link rel="stylesheet" media="all" href="/sites/default/files/css/css_d9gn2GRzRb_AMxXfgjVqY5zLMXvuwkXc1qKvoeAAIxE.css?delta=1&language=en&theme=bio_techne_global&include=eJxNzmFyhDAIBeALJeZIDImsUjFkIWnH21fXtttfb_hmeGDkTavzJ0HHLAQPlk6W7M_jy4Mf3mlPGZ1CZoVOZa0Ei2hGSXdE74dwXcLHc5AdMBi8ca1n30-GoroxQdXODy7YWWu6Lf63mEXLFhoaLoZt9TTbaCjTW6ZR28jCvtIcBA8dHfJgmc9r_UuLCjiVqyw003mUfs5oZU13QMbrnX0nKwTPwWVTu5Z_Lb5ter3zDT02d0M" /> <script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/8841","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"gtm":{"tagId":null,"settings":{"data_layer":"dataLayer","include_environment":false},"tagIds":["GTM-N2MWQDR"]},"gtag":{"tagId":"","consentMode":false,"otherIds":[],"events":[],"additionalConfigInfo":[]},"ajaxPageState":{"libraries":"eJxtkm124yAMRTcEYUkcgRVbE4wYIdK6qx85bpxO2z98XD3ZT0KJOCrmpWKcCycoITFrV4EW81Rd-hE_Nt91K1TnXwSUeWX-LbXAx-YLw7THPkOF7hhhxqrhhH6H_gHtmARkc6kwr4KQl9joHUuYQKHAhuLb6AuKSxqxLlAzThHNw4qSMST1T-pP6jspvtGEHu_2k-5O-ak4LJ-B-HdQvrFMKC_Ni13MXr6Zmm-EsbLSlTIocQ0H81-ZP9RnBSHhAndi6Q4LdKUcG-gSR0eJkDMP8xg-D15Qh1TfrD_WnXpzM_NcMCrMYbbl-_0Cf-D9f7g6qopSH26g0MfTqn1fNt-xYNbDpW8FMi5crEpnbnloTIP2a9A3zlxiN7GluwYCsw3O0sMko0G5vMhl1DZSIXupyTXhaWS1RJC8hGOLCcQJ9sa17zOhkMzvlYoZDS_uH9z1rSuuIUFH92gT1SvLetSxA_8FPIf1H-SbJog","theme":"bio_techne_global","theme_token":null},"ajaxTrustedUrl":[],"dataLayer":{"defaultLang":"en","languages":{"en":{"id":"en","name":"English","direction":"ltr","weight":0},"zh-hans":{"id":"zh-hans","name":"Chinese, Simplified","direction":"ltr","weight":1},"ja":{"id":"ja","name":"Japanese","direction":"ltr","weight":2}}},"internationalization":{"origin":{"id":"sg","label":"SG","country_name":"Singapore","alternate_spellings":"SG","country_enabled":true,"country_encased":false,"commerce_enabled":false,"credit_cards_enabled":true,"region":"North America - ROW","currency":"USD","localities":"","phone_pattern":"","country_shipping":"0","shipping_delay":3,"country_contact_message":"","product_block_message":"","default_language_setting":"none","default_contact_email":""},"languagePrefix":"\/"},"bloomreach_pixel":{"br_info":{"acct_id":"6368","domain_key":"biotechne"},"page_info":{"ptype":"content"},"order_info":{"order_id":""},"user_info":{"uid":0},"searchbar":{"enabled":"1","form":".product-search-form","input":"#edit-keywords"},"atc":{"enabled":"1","form":".add-to-cart-block"}},"user":{"uid":0,"permissionsHash":"085655eba91c5b5dd7808236555504ceb824f9fddd71e3c0265b4003df711142"}}</script> <script src="/sites/default/files/js/js_VXwrJf_GoEAY9I4SWeDh30VrU0-JgQhDzf_eoQcyzA4.js?scope=header&delta=0&language=en&theme=bio_techne_global&include=eJxtkeuSwyAIhV9I1kdykFB1aySDpNv06dc2Tad7-QV8MOcIxiLGlBuHWi4cMHEzHw8IdwgPONKoqJub0LDixuojZ7wU0e64YrdCYUHLYe2sAYlkbdb9MwFlW7XBMsSGVDu7YRKe1qlKxOqjiHVTXAJN7Z_-HqDbNgSSSyKpcjBMPtn8s8T0u_7AT7y6aIFbxkY8BSaZZ1ZiHw0OCi8KvRh_lYmBL2P_7l7jr4n9QaMh58KhiZVTIbQize8M3hnEKjT2riKzMlIOS7ly9a-DwrL2zOoWlWklC51RKfs9hIjqSjPW9lDDWm6H1bivbtC5MtnuAktF4ix1Gnp_L1nxtkEVnNzjs0o7ic672h3AGzjO_Q3uSNiw"></script> <script src="/modules/contrib/google_tag/js/gtm.js?snbwxk"></script> <script src="/modules/contrib/google_tag/js/gtag.js?snbwxk"></script> <script src="/sites/default/files/js/js_noO6VL3JUON9fTBkbqcAjEkLsfpTqx94dWIfXpNxuMg.js?scope=header&delta=3&language=en&theme=bio_techne_global&include=eJxtkeuSwyAIhV9I1kdykFB1aySDpNv06dc2Tad7-QV8MOcIxiLGlBuHWi4cMHEzHw8IdwgPONKoqJub0LDixuojZ7wU0e64YrdCYUHLYe2sAYlkbdb9MwFlW7XBMsSGVDu7YRKe1qlKxOqjiHVTXAJN7Z_-HqDbNgSSSyKpcjBMPtn8s8T0u_7AT7y6aIFbxkY8BSaZZ1ZiHw0OCi8KvRh_lYmBL2P_7l7jr4n9QaMh58KhiZVTIbQize8M3hnEKjT2riKzMlIOS7ly9a-DwrL2zOoWlWklC51RKfs9hIjqSjPW9lDDWm6H1bivbtC5MtnuAktF4ix1Gnp_L1nxtkEVnNzjs0o7ic672h3AGzjO_Q3uSNiw"></script> </head> <body class="node-8841 node-type-page"> <a href="#main-content" class="visually-hidden focusable"> Skip to main content </a> <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-N2MWQDR" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div id="page-wrapper"> <div id="page"> <header id="header" class="header" role="banner" aria-label="Site header"> <div class="section layout-container clearfix"> <section id="site-header__top"> <div class="container-fluid container-wide"> <div class="row m___navigation-utility-top"> <div class="col-xl-2 col-lg-12 text-xl-left text-lg-center"> <div id="site-header__logo" class="valign d-none d-lg-block mb-md-3"> <div> <div id="block-sitebranding" class="site-branding system_branding_block"> <a href="/" title="Home" rel="home" class="site-branding__logo"> <img width="160" height="28" src="/themes/custom/bio_techne_global/logo.svg" alt="Home" /> </a> </div> </div> </div> </div> <div class="col d-none d-xl-block text-lg-left text-md-center"> <div class="utility-bar-tagline rotating-text position-absolute"> <p class="ml-xl-4 bt-px_groteskbold text-white mb-0"> Global Developer, Manufacturer, and Supplier of High-Quality<br/> Reagents, Analytical Instruments, and Precision Diagnostics. </p> </div> <div class="utility-bar-brands rotating-text position-absolute ml-xl-4 text-white mb-0"> <div class="row"> <div class="col-2"> <div class="bt-px_groteskbold valign utility-bar-includes">INCLUDES</div> </div> <div class="col-lg-10 col-md-auto bt-inter"> <span class="mr-3">R&D Systems<sup>TM</sup></span> <span class="mr-3">Novus Biologicals<sup>TM</sup></span> <span class="mr-3">Tocris Bioscience<sup>TM</sup></span><br/> <span class="mr-3">ProteinSimple<sup>TM</sup></span> <span class="mr-3">ACD<sup>TM</sup></span> <span class="mr-3">ExosomeDx<sup>TM</sup></span> <span class="mr-3">Asuragen<sup style="font-size:11px;">®</sup></span> <span>Lunaphore<sup>TM</sup></span> </div> </div> </div> </div> <div class="col-xl-auto col-lg-12"> <div class="row"> <div class="col text-xl-left text-center"> </div> </div> <div class="row"> <div class="col text-xl-left text-center"> <nav id="site-header-top__left m___navigation-language"> <div> <div id="block-i18ncountryselect" class="i18n_country_select"> <div id="country-select-block-placeholder"> <div id="country-select-block-spinner" class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> </div> </div> </div> </nav> </div> </div> </div> </div> </div> </section> <div id="header-bg" class="bg-bt-secondary"> <section id="site-header__middle"> <div class="container-fluid container-wide"> <div class="row search-row"> <div id="hamburger-col" class="col-3 col-sm-3 col-md-2 d-block d-lg-none"> <button class="navbar-toggler collapsed" type="button" data-toggle="collapse" data-target="#navbarSupportedContent" aria-controls="navbarSupportedContent" aria-expanded="false" aria-label="Toggle navigation"> <span class="icon-bar top-bar"></span> <span class="icon-bar middle-bar"></span> <span class="icon-bar bottom-bar"></span> </button> </div> <div class="col-6 col-sm-6 col-md-8 d-block d-lg-none text-center"> <div id="site-header__logo" class="vertical-align mb-3"> <div> <div id="block-sitebranding" class="site-branding system_branding_block"> <a href="/" title="Home" rel="home" class="site-branding__logo"> <img width="160" height="28" src="/themes/custom/bio_techne_global/logo.svg" alt="Home" /> </a> </div> </div> </div> </div> <div id="tools-col" class="col-3 col-md-12 col-lg-auto order-sm-1 order-md-12 order-lg-12"> <div id="site-header__tools" class="vertical-align"> <div class="row"> <div class="col-md-12"> <div class="d-flex justify-content-end justify-content-md-center justify-content-lg-end"> <div class="text-right order-3 cart-not-available user_cart_information_block" id="block-biotechnecartinformation"> <span ></span> </div> <div class="mr-3 d-none d-md-block order-2 block-quickorderblock quick_order_block" id="block-quickorderblock"> </div> <div class="mr-3 order-1 user_account_information_block" id="block-biotechneuserinformation"> <a class="btn btn-primary" rel="nofollow" href="/account/login" role="button"> <span class="icon icon-bt-icon-user"></span> Sign In / Register </a> </div> </div> </div> </div> </div> </div> <div class="col order-sm-12 order-md-1 order-lg-1"> <div id="site-header__search">  <section role="search" class="vertical-align"> <div> <div class="block-product-search-form-block product_search_form_block" id="block-product-search-form-block"> <div class="row"> <div class="col-sm-12 search-bar mb-md-4"> <form class="product-search-form" action="/search" method="get" id="product-search-form" accept-charset="UTF-8" data-date="2024-11-21 07:11:32"> <div class="container-inline input-group" id="edit-container"> <div class="js-form-type-select"> <select class="dropdown-select text-dark-gray js-search-section-dropdown mr-2 pl-4 pr-5" id="edit-search-type" name="search_type" aria-label="Select search type"> <option value="products">Products</option> <option value="resources">Resources</option> </select> </div> <input placeholder="Search keyword, molecule name, target, catalog number, or product type..." autocomplete="off" class="form-control js-search-bar form-autocomplete form-text required ui-autocomplete-input" title="Search keyword, molecule name, target, catalog number, or product type..." data-autocomplete-path="/ajax/product-search/auto-suggest" type="text" id="product-search-keywords" name="keywords" value="" size="60" maxlength="256" required="required" aria-required="true" data-once="autocomplete" spellcheck="false"> <div class="form-actions" id="edit-actions"> <div class="input-group-append"> <input class="form-submit" type="submit" value=""> </div> </div> </div> </form> </div> </div> </div> </div> </section> </div> </div> </div> </div> </section> <section id="site-header__bottom"> <div class="container-fluid container-wide"> <div class="row"> <div class="col-md-12">  <nav id="main-nav"> <div> <div id="block-bio-techne-global-mainmenublock" class="main_menu_block"> <nav role="navigation" aria-labelledby="block-main-menu" id="block-main-menu" class="contextual-region navbar navbar-expand-md navbar-dark"> <div class="collapse navbar-collapse" id="navbarSupportedContent" data-date="2024-11-22 05:11:30"> <ul class="navbar-nav ml-auto"> <li class="nav-item dropdown d-md-none"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-quick-order" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Quick Order <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-quick-order" aria-labelledby="navbarDropdown-quick-order"> <div class="row"> <a href="/commerce/quickorder" class="dropdown-item text-wrap" title="Quick order form" data-drupal-link-system-path="commerce/quickorder">Quick Order Form</a> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-research-products" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Research Products <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-research-products" aria-labelledby="navbarDropdown-research-products"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Reagents & Kits<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/reagents/antibodies" class="dropdown-item text-wrap" data-drupal-link-system-path="node/276">Antibodies</a> <a href="/reagents/cell-culture-reagents" class="dropdown-item text-wrap" data-drupal-link-system-path="node/156">Cell Culture Reagents</a> <a href="/reagents/compound-libraries" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1096">Compound Libraries</a> <a href="/reagents/elisa-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/176">ELISA Kits</a> <a href="/reagents/elispot-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/141">ELISpot Kits</a> <a href="/reagents/enzymes" class="dropdown-item text-wrap" data-drupal-link-system-path="node/246">Enzymes</a> <a href="/reagents/fluorescent-dyes-probes" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6191">Fluorescent Dyes and Probes</a> <a href="/reagents/luminex-assays" class="dropdown-item text-wrap" data-drupal-link-system-path="node/181">Luminex Assays</a> <a href="/reagents/proteins" class="dropdown-item text-wrap" data-drupal-link-system-path="node/236">Proteins</a> <a href="/reagents/proteome-profiler-antibody-arrays" class="dropdown-item text-wrap" data-drupal-link-system-path="node/206">Proteome Profiler Antibody Arrays</a> <a href="/reagents/rnascope-ish-technology" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1626">RNAscope ISH Probes & Assays</a> <a href="/reagents/simple-plex-immunoassays" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1531">Simple Plex Immunoassays</a> <a href="/reagents/small-molecules-and-peptides" class="dropdown-item text-wrap" data-drupal-link-system-path="node/371">Small Molecules & Inhibitors</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> GMP Products<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/gmp-products/gmp-proteins" class="dropdown-item text-wrap" data-drupal-link-system-path="node/511">GMP Proteins</a> <a href="/gmp-products/gmp-small-molecules" class="dropdown-item text-wrap" data-drupal-link-system-path="node/366">GMP Small Molecules</a> <a href="/gmp-products/gmp-antibodies" class="dropdown-item text-wrap" data-drupal-link-system-path="node/13266">GMP Antibodies</a> <a href="/gmp-products/gmp-capabilities" class="dropdown-item text-wrap" title="GMP Capabilities" data-drupal-link-system-path="node/1071">GMP Capabilities</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Instruments<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/brands/proteinsimple" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3281">ProteinSimple Instruments</a> <a href="/instruments/ice" title="Our capillary electrophoresis instruments (icIEF and CE-SDS) provide reproducible quantitative analysis for thorough therapeutic protein characterization." class="dropdown-item text-wrap" data-drupal-link-system-path="node/256">iCE Maurice</a> <a href="/instruments/imagers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/536">Imagers</a> <a href="/instruments/luminex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/241">Luminex</a> <a href="/instruments/micro-flow-imaging" class="dropdown-item text-wrap" data-drupal-link-system-path="node/526">Micro-Flow Imaging</a> <a href="/instruments/simple-plex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/541">Simple Plex Ella</a> <a href="/instruments/simple-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/521">Simple Western</a> <a href="/instruments/single-cell-dispensers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6361">Single Cell Dispensers</a> <a href="/instruments/single-cell-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/531">Single-Cell Western</a> <a href="/instruments" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6731">View All Instruments</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Applications<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/methods/bioprocessing" class="dropdown-item text-wrap">Bioprocessing</a> <a href="/applications/crispr" class="dropdown-item text-wrap" data-drupal-link-system-path="node/9356">CRISPR</a> <a href="/applications/electrophysiology" class="dropdown-item text-wrap" data-drupal-link-system-path="node/426">Electrophysiology</a> <a href="/applications/flow-cytometry" class="dropdown-item text-wrap" data-drupal-link-system-path="node/321">Flow Cytometry</a> <a href="/applications/imaging" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10181">Imaging </a> <a href="/applications/immunoassays" class="dropdown-item text-wrap" data-drupal-link-system-path="node/496">Immunoassays</a> <a href="/resources/instrument-applications" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3341">Instrument Applications</a> <a href="/applications/mass-cytometry" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10071">Mass Cytometry (CyTOF)</a> <a href="/applications/spatial-biology" class="dropdown-item text-wrap" data-drupal-link-system-path="node/13416">Spatial Biology</a> <a href="/applications/vaccine-development" class="dropdown-item text-wrap" data-drupal-link-system-path="node/566">Vaccine Development</a> <a href="/applications/western-blotting" class="dropdown-item text-wrap" data-drupal-link-system-path="node/281">Western Blotting</a> <a href="/applications" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6736">View All Applications</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Research Areas<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/research-areas/cancer" class="dropdown-item text-wrap" data-drupal-link-system-path="node/8791">Cancer</a> <a href="/research-areas/cell-biology" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10661">Cell Biology</a> <a href="/research-areas/cell-and-gene-therapy" class="dropdown-item text-wrap" data-drupal-link-system-path="node/51">Cell & Gene Therapy</a> <a href="/research-areas/coronavirus" class="dropdown-item text-wrap" data-drupal-link-system-path="node/576">COVID-19</a> <a href="/research-areas/epigenetics" class="dropdown-item text-wrap" data-drupal-link-system-path="node/9511">Epigenetics</a> <a href="/research-areas/hypoxia" class="dropdown-item text-wrap" data-drupal-link-system-path="node/8846">Hypoxia</a> <a href="/research-areas/immunology" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10601">Immunology</a> <a href="/research-areas/immuno-oncology" class="dropdown-item text-wrap" data-drupal-link-system-path="node/381">Immuno-Oncology</a> <a href="/research-areas/metabolism" class="dropdown-item text-wrap" data-drupal-link-system-path="node/406">Metabolism</a> <a href="/research-areas/neuroscience" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10591">Neuroscience</a> <a href="/research-areas/organoids-3d-culture" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1452">Organoid and 3-D Culture</a> <a href="/research-areas/stem-cells" class="dropdown-item text-wrap" data-drupal-link-system-path="node/161">Stem Cells</a> <a href="/research-areas/targeted-protein-degradation" class="dropdown-item text-wrap" data-drupal-link-system-path="node/376">Targeted Protein Degradation</a> <a href="/research-areas" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6741">View All Research Areas</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-therapeutic-manufacturing" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Therapeutic Manufacturing <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-therapeutic-manufacturing" aria-labelledby="navbarDropdown-therapeutic-manufacturing"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Reagents & Kits<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/reagents/cell-culture-reagents/serum-free-animal-free" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3576">Animal-Free Cell Culture</a> <a href="/reagents/elisa-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/176">ELISA Kits</a> <a href="/therapeutic-manufacturing/simple-plex-assays" class="dropdown-item text-wrap" title="Bioprocess impurities and immunotitration" data-drupal-link-system-path="node/1311">Simple Plex Immunoassays</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> GMP Products<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/gmp-products/gmp-proteins" class="dropdown-item text-wrap" data-drupal-link-system-path="node/511">GMP Proteins</a> <a href="/gmp-products/gmp-small-molecules" class="dropdown-item text-wrap" data-drupal-link-system-path="node/366">GMP Small Molecules</a> <a href="/gmp-products/gmp-antibodies" class="dropdown-item text-wrap" data-drupal-link-system-path="node/13266">GMP Antibodies</a> <a href="/gmp-products/gmp-capabilities" class="dropdown-item text-wrap" title="GMP Capabilities" data-drupal-link-system-path="node/1071">GMP Capabilities</a> <a href="/gmp-products/ruo-to-gmp" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3421">Transition to GMP </a> <a href="/gmp-products/loa-request" class="dropdown-item text-wrap" data-drupal-link-system-path="node/13326">DMF/LOA Request</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Instruments<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/brands/proteinsimple" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3281">ProteinSimple Instruments</a> <a href="/instruments/ice" class="dropdown-item text-wrap" data-drupal-link-system-path="node/256">iCE Maurice</a> <a href="/instruments/imagers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/536">Imagers</a> <a href="/instruments/luminex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/241">Luminex</a> <a href="/instruments/micro-flow-imaging" class="dropdown-item text-wrap" data-drupal-link-system-path="node/526">Micro-Flow Imaging</a> <a href="/instruments/simple-plex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/541">Simple Plex Ella</a> <a href="/instruments/simple-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/521">Simple Western</a> <a href="/instruments/single-cell-dispensers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6361">Single Cell Dispensers</a> <a href="/instruments/single-cell-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/531">Single Cell Western</a> <a href="/instruments" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6731">View All Instruments</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Applications<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/methods/bioprocessing" class="dropdown-item text-wrap">Bioprocessing</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Research Areas<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/research-areas/cell-and-gene-therapy" class="dropdown-item text-wrap" data-drupal-link-system-path="node/51">Cell & Gene Therapy</a> <a href="/applications/immuno-oncology-clinical" class="dropdown-item text-wrap" data-drupal-link-system-path="node/2066">Immuno-Oncology</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-diagnostics" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Diagnostics <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-diagnostics" aria-labelledby="navbarDropdown-diagnostics"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Controls & Reagents<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/clinical-quality-controls" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7606">Clinical Quality Controls</a> <a href="/diagnostics/molecular-quality-controls" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5596">Molecular Controls</a> <a href="/diagnostics/controls-reagents/rnascope-ish-probe-high-risk-hpv" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5981">RNAscope™ ISH Probe High Risk HPV</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Kits<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/amplidex-genetic-testing-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5581">Genetics</a> <a href="/diagnostics/quantidex-oncology-testing-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5586">Oncology</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Technology<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/exosome" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5486">Exosome Platform</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> OEM Services<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/ivd-assay-development" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10881">IVD Assay Development</a> <a href="/diagnostics/ivd-contract-manufacturing" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7381">IVD Contract Manufacturing</a> <a href="/diagnostics/molecular-quality-controls/oem-and-commercial-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6781">Molecular Diagnostic OEM Services</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Companion Diagnostics<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/companion-diagnostics" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5631">Companion Diagnostics Services</a> <a href="/diagnostics/companion-diagnostics/multiomics" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10616">Multiomics Platform</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-services" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Services <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-services" aria-labelledby="navbarDropdown-services"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Custom Quotes<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/bulk-quotes" class="dropdown-item text-wrap" data-drupal-link-system-path="services/bulk-quotes">Bulk Quote Discounts</a> <a href="/services/custom-formulation" class="dropdown-item text-wrap" data-drupal-link-system-path="services/custom-formulation">Custom Formulation Quotes</a> <a href="/reagents/rnascope-ish-technology/probes/custom" class="dropdown-item text-wrap" data-drupal-link-system-path="node/12571">RNAscope Custom Probe Design Quote</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Custom Services<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/custom-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1891">All Custom Services</a> <a href="/services/custom-antibody-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/906">Custom Antibody Services</a> <a href="/services/custom-cell-and-gene-therapy-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1281">Custom Cell & Gene Therapy Services</a> <a href="/services/custom-compound-library-service" class="dropdown-item text-wrap" data-drupal-link-system-path="node/2126">Custom Compound Library Services</a> <a href="/services/custom-elisa-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/261">Custom ELISA Services</a> <a href="/services/gene-engineering-services-tcbuster" class="dropdown-item text-wrap" title="Gene Engineering Services: Bio-Techne" data-drupal-link-system-path="node/1136">Custom Gene Engineering Services</a> <a href="/services/custom-luminex-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/271">Custom Luminex Services</a> <a href="/services/custom-protein-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1441">Custom Protein Services</a> <a href="/services/custom-simple-plex-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6296">Custom Simple Plex Services</a> <a href="/services/custom-targeted-protein-degradation-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/861">Custom Targeted Protein Degradation Services</a> <a href="/services/professional-assay-services-rnascope" class="dropdown-item text-wrap" data-drupal-link-system-path="node/12306">RNAscope Professional Assay Services</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Instrument Services<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/certified-service-provider-program" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5446">Certified Service Provider (CSP) Program</a> <a href="/resources/instrument-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5471">Contract Services</a> <a href="/services/instrument-services/simple-western-service-plans" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3181">Simple Western Service Plans</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Licensing<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/biotechnology-licensing-partnering" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1101">Biotechnology Licensing and Partnering</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-resources" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Resources <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-resources" aria-labelledby="navbarDropdown-resources"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Product & Instrument Tools<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/resources/cofa-finder-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/cofa-finder-tool">Certificate of Analysis (COA) Finder Tool</a> <a href="/resources/calculators" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7416">Calculators</a> <a href="/resources/flow-cytometry-panel-builder" class="dropdown-item text-wrap" data-drupal-link-system-path="node/8821">Flow Cytometry Panel Builder</a> <a href="/luminex-assay-customization-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="luminex-assay-customization-tool">Luminex Assay Customization Tool</a> <a href="/resources/product-insert-lookup-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/product-insert-lookup-tool">Product Insert Lookup Tool</a> <a href="/resources/rnascope-citations" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/rnascope-citations">RNAscope Citations</a> <a href="/resources/simple-plex-panel-builder" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/simple-plex-panel-builder">Simple Plex Panel Builder</a> <a href="/resources/simple-western-kit-builder" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/simple-western-kit-builder">Simple Western Kit Builder</a> <a href="/resources/simple-western-antibody-database" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/simple-western-antibody-database">Simple Western Antibody Database</a> <a href="/resources/single-cell-western-antibody-database" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/single-cell-western-antibody-database">Single-Cell Western Antibody Database</a> <a href="/resources/spectra-viewer" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6176">Spectra Viewer</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Scientific Resources<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/resources/blogs" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/blogs">Blogs</a> <a href="/resources/literature" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/literature">Literature</a> <a href="/resources/podcasts/biotech-podcast-back-of-the-napkin" class="dropdown-item text-wrap" data-drupal-link-system-path="node/8601">Podcasts</a> <a href="/resources/protocols-troubleshooting" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/protocols-troubleshooting">Protocols & Troubleshooting</a> <a href="/resources/scientific-articles" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/scientific-articles">Scientific Articles</a> <a href="/resources/signal-transduction-pathways" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/signal-transduction-pathways">Signal Transduction Pathways</a> <a href="/resources/testimonials" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/testimonials">Testimonials & Interviews</a> <a href="/resources/webinars" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1596">Webinars</a> <a href="/resources/videos" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/videos">Videos</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Instrument Resources<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/resources/instrument-applications" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3341">Instrument Applications</a> <a href="/resources/instrument-citations" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/instrument-citations">Instrument Citations</a> <a href="/resources/protocols" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/protocols">Instrument Protocols</a> <a href="/resources/instrument-software-download-center" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/instrument-software-download-center">Instrument Software</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-about" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> About <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-about" aria-labelledby="navbarDropdown-about"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> About Us<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/welcome-to-bio-techne" class="dropdown-item text-wrap" data-drupal-link-system-path="node/876">Welcome to Bio-Techne.com!</a> <a href="/about/about-bio-techne" class="dropdown-item text-wrap" data-drupal-link-system-path="node/16">About Bio-Techne</a> <a href="/brands" class="dropdown-item text-wrap" data-drupal-link-system-path="node/46">Bio-Techne Brands</a> <a href="/about/corporate-and-social-responsibility" class="dropdown-item text-wrap" data-drupal-link-system-path="node/61">Corporate & Social Responsibility</a> <a href="https://investors.bio-techne.com/" target="_blank" class="dropdown-item text-wrap">Investor Relations</a> <a href="/about/quality" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6056">Quality</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Latest at Bio-Techne<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/about/careers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/21">Careers</a> <a href="/about/events" class="dropdown-item text-wrap" data-drupal-link-system-path="node/786">Events</a> <a href="/programs" class="dropdown-item text-wrap" data-drupal-link-system-path="node/4621">Programs & Promotions</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Support<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/support/contact-us" class="dropdown-item text-wrap" data-drupal-link-system-path="node/96">Contact & Support</a> <a href="/distributors" class="dropdown-item text-wrap" data-drupal-link-system-path="node/9936">Distributors</a> </div> </div> </div> </div> </div> </li> </ul> </div> </nav> </div> </div> </nav> </div> </div> </div> </section> </div> </div> </header> </div> <div class="highlighted"> <aside class="container section clearfix" role="complementary"> <div> </div> </aside> </div> <div id="main" class="container-fluid container-wide "> <div class="row"> <div class="col-md-12"> <div> <div id="block-bio-techne-global-breadcrumbs" class="system_breadcrumb_block"> <nav role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/research-areas">Research Areas</a> </li> <li> <a href="/research-areas/immunology">Immunology Research</a> </li> <li> Immunology Cell Identity Markers: Adaptive Immunity </li> </ol> </nav> </div> </div> </div> </div> <div class="row"> <div class="col-md-12"> <main> <section class="section"> <div> <div id="block-bio-techne-global-content" class="system_main_block"> <article> <div> <div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h1>Adaptive Immunology Cell Identity Markers</h1></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a href="#adaptive">Adaptive Immunity</a> | <a href="#t-cell">T Cell Subsets</a> | <a href="#b-cell">B Cell Subsets</a> | <a href="#references">References</a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2><strong><a name="adaptive"></a>Adaptive Immunity</strong></h2><p>Adaptive immune responses are mediated by cellular (lymphocytes) effectors, soluble (cytokines) effectors, and humoral (plasma cell-derived antibodies) effectors. Versatility and memory are the two main distinguishing properties of the adaptive arm of the immune system. Versatility is underscored by genetic recombination mechanisms which ensure the expression of immune receptors with high specificity for antigen recognition in T and B lymphocytes. Immune memory results from the persistence of long lived lymphocytes with antigen specific receptors and antibody-secreting plasma cells, which are able to mount a rapid immune response upon re-stimulation.</p></div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2><a name="t-cell"></a>T Cell Subsets</h2> <p> </p> <h3>Adaptive Cellular Mediators: Functions and Markers</h3> <figure class="responsive-figure-table"><table class="table table-striped"> <thead> <tr> <th class="bt-blue-table-header">T Cell Subsets</th> <th class="bt-blue-table-header">Function</th> <th class="bt-blue-table-header">Markers</th> </tr> </thead> <tbody> <tr> <td><strong>Naïve T lymphocytes</strong><br>  </td> <td>Mature T lymphocytes present in the blood and lymphoid organs without previous antigen interaction and thus inactive. Interaction with peptides presented through cells of the innate immune system, such as dendritic cells serving as antigen presenting cells, leads to T cell activation.</td> <td><a href="/t/cd45ra">CD45RA</a>, <a href="/t/l-selectin-cd62l">CD62L</a>, <a href="/t/ccr7">CCR7</a>, <a href="/t/cd27-tnfrsf7">CD27</a>, <a href="/t/cd28">CD28</a>, <a href="/search?search_type=products&keywords=cd25-il-2-r-alpha">CD25</a></td> </tr> <tr> <td><strong>Effector T lymphocytes</strong><br>  </td> <td> <p>Once activated, naïve <a href="/t/cd4">CD4+ </a>and <a href="/t/cd8">CD8+</a> T lymphocytes generate different cell subsets.<br> <strong>CD8+ subsets: Tc1 and Tc2<br> CD4+ subsets: Th1, Th2, Th17 and Treg (<a href="/t/foxp3">Foxp3</a>)</strong></p>   <p>Activated T cells perform cytotoxic functions via two main mechanisms:<br> <br> <strong>Cell-mediated</strong>- via cytotoxic CD8+ T cell induced lysis of damaged cells (infected or transformed)<br> <br> <strong>Soluble factors-mediated</strong>- via CD4+ T helper cell dependent release of cytokines that are toxic to infected cells or promote the activity of other immune cells (e.g., increase of antibody production and activity of NK cells)</p> </td> <td><a href="/t/cd69">CD69</a>, <a href="/search?search_type=products&keywords=cd25-il-2-r-alpha">CD25</a>, <a href="/t/cd45ro">CD45RO</a>, <a href="/t/ox40-tnfrsf4">OX40</a>, <a href="/t/4-1bb-ligand-tnfsf9">4-1BBL</a>, <a href="/t/fas-tnfrsf6-cd95">CD95</a>, <a href="/t/granzyme-b">Granzyme B</a>, <a href="/t/perforin">Perforin</a>, <a href="/t/cd44">CD44</a></td> </tr> </tbody> </table></figure> <h3>Memory T Cells</h3> <p>Following exposure to an antigen, a small subset of effector T cells differentiate into memory cells and remain for years in peripheral lymphoid and non-lymphoid tissues. Memory T cells maintain their antigen specificity and help to amplify the immune response during antigen re-exposure. Memory T cells conform a heterogeneous population consisting of effector and central memory subsets. Some relevant markers include <a href="/t/ccr7">CCR7</a>, <a href="/t/l-selectin-cd62l">CD62L</a>, <a href="/t/cd45ro">CD45RO</a>, <a href="/t/cd45ra">CD45RA</a>, <a href="/t/fas-tnfrsf6-cd95">CD95</a>, <a href="/search?search_type=products&keywords=il-7-r-alpha-cd127">CD127</a>, <a href="/t/cd28">CD28</a> and <a href="/t/granzyme-b">Granzyme B</a>.</p></div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-media-to-text mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/immunology-cell-identity-markers-fig-1.3.jpg" alt="CD4 expression in human T cells ICC" loading="lazy" > </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>CD4 was detected in immersion fixed human T cells using 2 μg/mL Goat Anti-Human CD4 Antigen Affinity-purified Polyclonal Antibody (Catalog #<a href="/p/antibodies/human-cd4-antibody_af-379-na">AF-379-NA</a>) for 3 hours at room temperature. Cells were stained (red) and counterstained (green). View our protocol for <a href="/resources/protocols-troubleshooting/icc-cell-smear-protocol-suspension-cells">Fluorescent ICC Staining of Cells on Coverslips</a>.</p></div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-media-to-text mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/immunology-cell-identity-markers-fig-2.3.jpg" alt="Intracellular perforin expression in CD8 T cells ICC" loading="lazy" > </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>Immunocytochemistry/Immunofluorescence: Perforin Antibody (deltaG9) [<a href="/search?=products&keywords=perforin-antibody-deltag9">NBP1-45774</a>] - Isolated CD8 T-cells showing intracellular perforin (green).</p></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h3>Humoral Markers</h3><p>In addition to the use of CD markers for the identification of T cell subsets, various effector molecules specifically produced and secreted by T cells may facilitate their identification. Several types of cytokines are released from T cell subsets and may play both pro- and anti-inflammatory roles. Cytokines modulate the activity of T and B cells by influencing their growth, mobility and differentiation.</p><figure class="responsive-figure-table"><table class="table table-striped"><thead><tr><th class="bt-blue-table-header">T Cell Subsets</th><th class="bt-blue-table-header">Effector Molecules</th></tr></thead><tbody><tr><td>Th1</td><td><a href="/t/ifn-gamma">IFN-γ</a>, <a href="/t/tnf-alpha">TNF-α</a>, <a href="/t/il-2">IL-2</a>, <a href="/t/lymphotoxin">Lymphotoxin</a></td></tr><tr><td>Th2</td><td><a href="/t/il-4">IL-4</a>, <a href="/t/il-5">IL-5</a>, <a href="/t/il-10">IL-10</a>, <a href="/t/il-13">IL-13</a></td></tr><tr><td>Th17</td><td><a href="/t/il-17-il-17a">IL-17</a>, <a href="/t/il-21">IL-21</a>, <a href="/t/il-22">IL-22</a>, <a href="/search?search_type=products&keywords=il-25">IL-25</a>, <a href="/t/il-26-ak155">IL-26</a></td></tr><tr><td>Treg</td><td><a href="/t/il-10">IL-10</a>, <a href="/t/tgf-beta-1">TGF-β</a></td></tr><tr><td>T (CTL)</td><td><a href="/t/perforin">Perforin</a>, <a href="/t/granzyme-b">Granzymes</a>, <a href="/t/ifn-gamma">IFN-γ</a>, <a href="/t/tnf-alpha">TNF-α</a>, <a href="/t/lymphotoxin-alpha-tnf-beta">TNF-β</a></td></tr></tbody></table></figure><p> </p><h3>γδ T and NK T Cells Bridge Innate and Adaptive Immunity</h3><p><strong>γδ</strong> T cells comprise a relatively small subset of T cells (up to 5% of peripheral blood mononuclear cells). Similar to conventional T cells the smaller subset of γδ T cells is thymus derived, but differs in T cell receptor (TCR) composition, expressing a <a href="/t/tcr-gamma-delta">γδ</a> heterodimer rather than an <a href="/t/tcr-alpha-beta">αβ</a> TCR. γδ T cells may be found in peripheral blood and associated with epithelial tissues, where they play a role in innate immunity recognizing infectious antigens and tumor cells. γδ T cells express natural killer receptors and TCRs, thereby connecting both arms of immunity.</p><figure class="responsive-figure-table"><table class="table table-striped"><thead><tr><th class="bt-blue-table-header">γδ T types</th><th class="bt-blue-table-header">Function</th><th class="bt-blue-table-header">Effector Molecules and Markers</th></tr></thead><tbody><tr><td>Vδ1</td><td>Mainly found in mucosal epithelium where they provide immune defense against infections and transformed cells</td><td><a href="/t/il-10">IL-10</a></td></tr><tr><td>Vδ2</td><td>Predominant subset of peripheral γδ T cells which serve as antigen presenting cells (APCs)</td><td>MHCII (<a href="/t/hla-dr">HLA-DR</a>), <a href="/t/b7-1-cd80">CD80</a>, <a href="/t/b7-2-cd86">CD86</a></td></tr><tr><td>Vδ3</td><td>Not frequently found in blood but may be present in organs (e.g., liver), and may promote maturation of APCs</td><td>MHCII (<a href="/t/hla-dr">HLA-DR</a>), <a href="/t/ncam-1-cd56">CD56</a>, <a href="/t/cd161">CD161</a>, <a href="/t/nkg2d-cd314">NKG2D</a></td></tr></tbody></table></figure><p> </p><p><strong>Natural Killer T cells (NKT)</strong> represent a small subtype of circulating T lymphocytes that are functionally similar to both NK and T cells. NKT cells diverge from conventional T cells in TCR expression and recognize <a href="/t/cd1d">CD1d</a> associated lipid antigens. Type I NKT cells represent the more prevalent subset and are characterized by the expression of TCRs with an invariant alpha chain (<a href="/p/antibodies/v-alpha-24-j-alpha-18-tcr-antibody-6b11_nbp2-00267">Vα14–Jα18 </a>). NKT cells may also be identifiable by expression of <a href="/t/cd161">CD161</a>, <a href="/t/klra1">Ly49</a>, <a href="/t/nkg2a-cd159a">NKG2</a> and <a href="/t/cd3">CD3</a> as well as <a href="/t/cd44">CD44</a> and <a href="/t/il-2-r-beta">CD122</a> upon activation.</p><p> </p></div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--full-page-text-with-media mb-4 paragraph--view-mode--default"> <div><h3>Cells of the Innate and Adaptive Immune System</h3></div> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/immunology-cell-identity-markers-fig-4v3.png" alt="Gamma Delta T and NK T cells bridge innate and adaptive immunity" loading="lazy" > </div> <div><p><em>Cells of the innate immunity branch provide a rapid response to non-self antigens, in contrast cells of the adaptive immunity branch provide a slower but highly specific response. Several cell subsets, including γδ T cells and NKT cells, connect both branches of immunity because they express receptors similar to those in conventional B and T cells. Even though the specificity of these receptor is limited, the response to specific non-self antigens is prompt.</em></p></div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2><a name="b-cell"></a>B Cell Subsets</h2><p>Knowledge about the role of B cells in immunity continues to expand. Traditionally, B cells have been recognized for their unique capacity to produce antibodies, however identification of B cell subtypes with unique functions and localization have clarified B cell contributions to both adaptive and innate immunity. Recently, B cells have been shown to participate in various antibody-independent roles in immunity including:</p><ul><li>Antigen presentation</li><li>Cytokine production</li><li>Modulating the response of other immune cells (e.g., T cells)</li><li>Tissue repair</li></ul><h3>Functions and Markers</h3><h4>Adaptive Cellular Mediators</h4><figure class="responsive-figure-table"><table class="table table-striped"><thead><tr><th class="bt-blue-table-header">Cell Type</th><th class="bt-blue-table-header">Location and Function</th><th class="bt-blue-table-header">Markers</th></tr></thead><tbody><tr><td>Long-lived Follicular B cells</td><td>Mature B cells present in secondary lymphoid tissues which may give rise to short-lived plasma cells, antibody-secreting plasma cells, and memory B cells.</td><td>Mice: <a href="/t/cd23-fc-epsilon-rii">CD23</a>, <a href="/t/cd21">CD21</a>, <a href="/t/cd1d">CD1d</a>, <a href="/t/cxcr5">CXCR5</a><br><br>Human: <a href="/t/cd23-fc-epsilon-rii">CD23</a>, <a href="/t/cd21">CD21</a>, <a href="/t/cxcr5">CXCR5</a><br><br>Plasmablast: <a href="/t/syndecan-1-cd138">CD138</a> (mice), <a href="/t/cd38">CD38</a>, <a href="/t/cd27-tnfrsf7">CD27</a><br><br>Plasma cells: <a href="/t/cd38">CD38</a> (human), <a href="/t/cd27-tnfrsf7">CD27</a>, <a href="/t/syndecan-1-cd138">CD138</a> (mice)</td></tr></tbody></table></figure><h4>Innate Cellular Mediators</h4><figure class="responsive-figure-table"><table class="table table-striped"><thead><tr><th class="bt-blue-table-header">Cell Type</th><th class="bt-blue-table-header">Location and Function</th><th class="bt-blue-table-header">Markers</th></tr></thead><tbody><tr><td>Splenic Marginal Zone B cells</td><td>Mature B cells that interface the circulatory and lymphatic tissues. Provide rapid defense against blood pathogens. IgM and IgG3 antibody responses are elicited by interactions between bacterial antigens and B cell receptors (BCRs) or Toll-like receptors (TLRs).</td><td><p>Mice: <a href="/t/cd21">CD21</a>, <a href="/t/cd1d">CD1d</a>, <a href="/t/cd9">CD9</a>, <a href="/t/cd35">CD35</a>, <a href="/t/b7-1-cd80">CD80</a>, <a href="/t/b7-2-cd86">CD86</a></p><p>Human:<a href="/t/fcrl4-fcrh4"> IRTA1</a>, <a href="/t/fcrl5">IRTA2</a>, <a href="/t/cd1c-bdca-1">CD1c</a>, <a href="/t/cd27-tnfrsf7">CD27</a>, <a href="/t/cd21">CD21</a></p></td></tr><tr><td>B1 cells</td><td>Mature B cell subset present in tissues (e.g., intestine, peritoneal cavity). Responsible for IgM and IgG3 antibody responses following exposure to bacterial antigens and to polysaccharide antigens. Derived from the fetal liver and produce the majority of natural low-affinity IgM antibodies as well as antigen-specific antibodies.</td><td><p>Mice:  <a href="/t/cd5">CD5</a>, <a href="/t/cd43">CD43</a>, <a href="/search?search_type=products&keywords=il-5-r-alpha-cd125">IL-5R</a>, <a href="/t/b220-cd45r">B220</a>, <a href="/t/cd9">CD9</a></p><p>Human: <a href="/t/cd20">CD20</a>, <a href="/t/cd27-tnfrsf7">CD27</a>, <a href="/t/cd43">CD43</a>, <a href="/t/cd5">CD5</a></p></td></tr></tbody></table></figure><p>Additional markers include the pan B cell marker <a href="/t/cd19">CD19</a>.</p><p> </p></div> </div> </div> <div> <div class="paragraph paragraph--type--individual-button mb-4 paragraph--view-mode--default w-100"> <div class="row"> <div class="col"> <a href="/research-areas/immunology/b-cell-development-and-differentiation-markers" class="btn btn-primary" type="link" > Learn about B Cell Developmental Markers </a> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="references"></a></p></div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-selected-references0" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Selected References</h5> </a> </div> <div class="collapse" id="expPara-selected-references0" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>Baumgarth N. (2016) B-1 Cell Heterogeneity and the Regulation of Natural and Antigen-Induced IgM Production. <em>Frontiers in immunology</em>, 7, 324. <a href="https://doi.org/10.3389/fimmu.2016.00324">https://doi.org/10.3389/fimmu.2016.00324</a><br><br>Bonilla, F. A., & Oettgen, H. C. (2010) Adaptive immunity. <em>Journal of Allergy and Clinical Immunology.</em> <a href="https://doi.org/10.1016/j.jaci.2009.09.017">https://doi.org/10.1016/j.jaci.2009.09.017</a><br><br>Cerutti, A., Cols, M., & Puga, I. (2013) Marginal zone B cells: Virtues of innate-like antibody-producing lymphocytes. <em>Nature Reviews Immunology.</em> <a href="https://doi.org/10.1038/nri3383">https://doi.org/10.1038/nri3383</a><br><br>Croft, M., So, T., Duan, W., & Soroosh, P. (2009) The significance of OX40 and OX40L to T-cell biology and immune disease. <em>Immunological Reviews.</em> <a href="https://doi.org/10.1111/j.1600-065X.2009.00766.x">https://doi.org/10.1111/j.1600-065X.2009.00766.x</a><br><br>Garraud, O., Borhis, G., Badr, G. <em>et al.</em> (2012) Revisiting the B-cell compartment in mouse and humans: More than one B-cell subset exists in the marginal zone and beyond. <em>BMC Immunology.</em> <a href="https://doi.org/10.1186/1471-2172-13-63">https://doi.org/10.1186/1471-2172-13-63</a><br><br>Golubovskaya, V. & Wu, L. (2016) Different subsets of T cells, memory, effector functions, and CAR-T immunotherapy. <em>Cancers.</em> <a href="https://doi.org/10.3390/cancers8030036">https://doi.org/10.3390/cancers8030036</a><br><br>Hatzivassiliou, G., Miller, I., Takizawa, J. <em>et al.</em> (2001) IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. <em>Immunity.</em> <a href="https://doi.org/10.1016/S1074-7613(01)00109-1">https://doi.org/10.1016/S1074-7613(01)00109-1</a><br><br>Ikeda, J. ichiro, Kohara, M., Tsuruta, Y. <em>et al.</em> (2017) Immunohistochemical analysis of the novel marginal zone B-cell marker IRTA1 in malignant lymphoma. <em>Human Pathology.</em> <a href="https://doi.org/10.1016/j.humpath.2016.09.011">https://doi.org/10.1016/j.humpath.2016.09.011</a><br><br>Janeway C.A. Jr, Travers P., Walport M. <em>et al.</em> Immunobiology: The Immune System in Health and Disease. 5th edition. New York: Garland Science; 2001. General properties of armed effector T cells. Available from: <a href="https://www.ncbi.nlm.nih.gov/books/NBK27149/">https://www.ncbi.nlm.nih.gov/books/NBK27149/</a><br><br>Liao, C. M., Zimmer, M. I., & Wang, C. R. (2013) The functions of type I and type II natural killer T cells in inflammatory bowel diseases. <em>Inflammatory Bowel Diseases.</em> <a href="https://doi.org/10.1097/MIB.0b013e318280b1e3">https://doi.org/10.1097/MIB.0b013e318280b1e3</a><br><br>Oliveira, J. B. (2014) Marginal zone B-cell dysfunction in ALPS. <em>Blood.</em> <a href="https://doi.org/10.1182/blood-2014-07-585935">https://doi.org/10.1182/blood-2014-07-585935</a><br><br>Rothstein, T. L., Griffin, D. O., Holodick, N. E. <em>et al.</em> (2013) Human B-1 cells take the stage. <em>Annals of the New York Academy of Sciences.</em> <a href="https://doi.org/10.1111/nyas.12137">https://doi.org/10.1111/nyas.12137</a><br><br>Sanz, I., Wei, C., Lee, F. E. H., & Anolik, J. (2008) Phenotypic and functional heterogeneity of human memory B cells. <em>Seminars in Immunology.</em> <a href="https://doi.org/10.1016/j.smim.2007.12.006">https://doi.org/10.1016/j.smim.2007.12.006</a><br><br>Seino, K., & Taniguchi, M. (2005) Functionally distinct NKT cell subsets and subtypes: <em>The Journal of Experimental Medicine.</em> <a href="https://doi.org/10.1084/jem.20051600">https://doi.org/10.1084/jem.20051600</a><br><br>Won, W.-J., & Kearney, J. F. (2002) CD9 is a unique marker for marginal zone B cells, B1 cells, and plasma cells in mice. <em>The Journal of Immunology.</em> <a href="https://doi.org/10.4049/jimmunol.168.11.5605">https://doi.org/10.4049/jimmunol.168.11.5605</a><br><br>Wu, Y. L., Ding, Y. P., Tanaka, Y. <em>et al.</em> (2014. γδ T cells and their potential for immunotherapy. International Journal of Biological Sciences. <a href="https://doi.org/10.7150/ijbs.7823">https://doi.org/10.7150/ijbs.7823</a><br><br>Zouali, M., & Richard, Y. (2011) Marginal zone B-cells, a gatekeeper of innate immunity. <em>Frontiers in Immunology.</em> <a href="https://doi.org/10.3389/fimmu.2011.00063">https://doi.org/10.3389/fimmu.2011.00063</a></p></div> </div> </div> </div> </div> </div> </div> </article> </div> </div> </section> </main> </div> </div> </div> <div id="brandsbar-footer" class="bg-bt-primary"> <div class="container-wide container-fluid text-white"> <div class="row py-5"> <div class="footer-logo col-xl-3 col-lg-auto d-flex"> <img class="brand-bar-footer-logo" src="/themes/custom/bio_techne_global/logo.svg" alt="Bio-techne logo"> </div> <div class="col-xl-9 col-lg-auto"> <p class="ml-xl-4 bt-px_groteskbold footer-tagline">Global Developer, Manufacturer, and Supplier of High-Quality Reagents, Analytical Instruments, and Precision Diagnostics.</p> </div> <div class="included-brands col"> <span class="font-weight-bold mr-3 bt-inter_regular">INCLUDES</span> <span class="mr-3 bt-inter_regular">R&D Systems™</span> <span class="mr-3 bt-inter_regular">Novus Biologicals™</span> <span class="mr-3 bt-inter_regular">Tocris Bioscience™</span> <span class="mr-3 bt-inter_regular">ProteinSimple™</span> <span class="mr-3 bt-inter_regular">ACD™</span> <span class="mr-3 bt-inter_regular">ExosomeDx™</span> <span class="mr-3 bt-inter_regular">Asuragen™</span> <span class="mr-3 bt-inter_regular">Lunaphore™</span> </div> </div> </div> </div> <div id="site-footer__top" class=" pt-4"> <div class="container-wide container-fluid pt-3"> <div> <div class="col-md-12"> <footer> <div> <div class="row"> <div class="col-xl-3 col-md-6 col-xs-12 p-0 text-white bt-inter_regular"> <div> <div id="block-footercolumn1" class="block_content:8da4adc8-094f-4085-8706-613703de4da6"> <div><h4>CONTACT INFORMATION</h4> <p>614 McKinley Place NE<br /> Minneapolis, MN 55413<br /> USA</p> <p>TEL <a href="tel:612 379 2956">612 379 2956</a><br /> Toll-free <a href="tel:800 343 7475">800 343 7475</a><br /> FAX 612 656 4400</p> </div> </div> </div> </div> <div class="col-xl-3 col-md-6 col-xs-12 p-0 bt-inter_regular"> <div> <nav role="navigation" aria-labelledby="block-footercolumn2-menu" id="block-footercolumn2"> <h4 id="block-footercolumn2-menu">Who We Are</h4> <ul> <li> <a href="/about/about-bio-techne" title="About Bio-Techne" data-drupal-link-system-path="node/16">About Bio-Techne</a> </li> <li> <a href="/brands" title="Brands" data-drupal-link-system-path="node/46">Bio-Techne Brands</a> </li> <li> <a href="/about/careers" title="History" data-drupal-link-system-path="node/21">Careers </a> </li> <li> <a href="/about/corporate-and-social-responsibility" title="Corporate Responsibility" data-drupal-link-system-path="node/61">Corporate & Social Responsibility </a> </li> <li> <a href="/terms-and-conditions" data-drupal-link-system-path="node/686">Terms and Conditions</a> </li> </ul> </nav> </div> </div> <div class="col-xl-3 col-md-6 col-xs-12 p-0 bt-inter_regular"> <div> <nav role="navigation" aria-labelledby="block-footercolumn3-menu" id="block-footercolumn3"> <h4 id="block-footercolumn3-menu">Investor Relations</h4> <ul> <li> <a href="https://investors.bio-techne.com/">Overview</a> </li> <li> <a href="https://investors.bio-techne.com/news-events">News / Events</a> </li> <li> <a href="https://investors.bio-techne.com/company-information">Company Information</a> </li> <li> <a href="https://investors.bio-techne.com/financial-information">Financial Information</a> </li> <li> <a href="https://investors.bio-techne.com/stock-data">Stock Data</a> </li> <li> <a href="https://investors.bio-techne.com/sec-filings">SEC Filings</a> </li> <li> <a href="https://investors.bio-techne.com/corporate-governance">Corporate Governance</a> </li> </ul> </nav> </div> </div> <div class="col-xl-3 col-md-6 col-xs-12 p-0 text-white bt-inter_regular"> <div> <div id="block-stayconnectedblock" class="block_content:3f9f347f-6b53-40fd-8dfa-25f57854770b"> <div><h4>Stay Connected</h4> <section class="social-icons mb-3"> <a href="https://www.linkedin.com/company/bio-techne" class="text-white mr-2" aria-label="Follow Bio-techne on LinkedIn"><span class="icon-linkedin rounded-pill p-3"></span></a> <a href="https://www.instagram.com/bio_techne/" class="text-white mr-2" aria-label="Follow Bio-techne on Instagram"><span class="icon-instagram rounded-pill p-3"></span></a> <a href="https://twitter.com/biotechne" class="text-white mr-2" aria-label="Follow Bio-techne on X"><span class="icon-x rounded-pill p-3"></span></a> <a href="https://www.youtube.com/channel/UCCE68f793S1eyQM2E1BH0Bw?reload=9" class="text-white mr-2" aria-label="Bio-techne YouTube channel"><span class="icon-youtube rounded-pill p-3"></span></a> <a href="https://www.facebook.com/BioTechne/" class="text-white" aria-label="Follow Bio-techne on Facebook"><span class="icon-facebook rounded-pill p-3"></span></a> </section></div> </div> </div> <div> <a href="/support/contact-us" class="py-2 mt-3 mb-4 text-center font-weight-bold text-decoration-none text-white">Contact Us </a> </div> </div> </div> </div> </footer> </div> <hr> <div class="pb-5 mt-4 d-flex flex-wrap legal-navigation"> <div class="mb-2"> <a href="https://www.bio-techne.com/privacy-and-cookie-policy" class="mr-4 text-white text-center">Privacy and Cookie Policy</a> </div> <div class="mb-2"> <a href="/sitemap" class="mr-4 text-white">Site Map</a> </div> <div class="text-white">© Copyright 2024 Bio-Techne. All Rights Reserved.</div> </div> </div> </div> </div> </div> <div> <div id="block-cookieblock" class="cookie_block"> <div class="cookie-notification-block" data-expires="100"> <div class="container"> <div class="row pt-4 pb-4 pl-5 pr-5"> <div class="col-lg-10 mb-1"> Bio-Techne uses cookies to provide you with a great website experience. By continuing to use this website you acknowledge this and agree to our cookie policy. <a class="cookie-notification-block__link text-white" href="/privacy-and-cookie-policy">Learn more</a>. </div> <div class="col-lg-2 text-lg-right text-center align-middle"> <a href="#" class="btn btn-primary text-nowrap js-cookies"> I Agree </a> </div> </div> </div> </div> </div> </div> </div> <div class="embeddedServiceInvitation" id="snapins_invite" aria-live="assertive" role="dialog" aria-atomic="true" style="display: none;"> <div class="embeddedServiceInvitationHeader" aria-labelledby="snapins_titletext" aria-describedby="snapins_bodytext"> <img id="embeddedServiceAvatar"/> <span class="embeddedServiceTitleText" id="snapins_titletext">Need help?</span> <button type="button" id="closeInvite" class="embeddedServiceCloseIcon" aria-label="Exit invitation">×</button> </div> <div class="embeddedServiceInvitationBody"> <p id="snapins_bodytext">How can we help you?</p> </div> <div class="embeddedServiceInvitationFooter" aria-describedby="snapins_bodytext"> <button type="button" class="embeddedServiceActionButton" id="rejectInvite">Close</button> <button type="button" class="embeddedServiceActionButton" id="acceptInvite">Start Chat</button> </div> </div> <script>window.dataLayer = window.dataLayer || []; window.dataLayer.push({"drupalLanguage":"en","drupalCountry":"US","siteName":"Bio-Techne","brand":"R\u0026D","entityLangcode":"und","entityStatus":"1","entityType":"node","entityBundle":"page","entityId":"8841","entityTitle":"Immunology Cell Identity Markers: Adaptive Immunity","entityTaxonomy":{"brand":{"327":"Novus Biologicals"},"product_category":{"121":"Antibodies"},"research_area":{"206":"Immunology"}},"userUid":0});</script> <script src="/sites/default/files/js/js_25fMqnS_SV9QKFCPxa9BJeVftykwhKcx00psCZOkjfs.js?scope=footer&delta=0&language=en&theme=bio_techne_global&include=eJxtkeuSwyAIhV9I1kdykFB1aySDpNv06dc2Tad7-QV8MOcIxiLGlBuHWi4cMHEzHw8IdwgPONKoqJub0LDixuojZ7wU0e64YrdCYUHLYe2sAYlkbdb9MwFlW7XBMsSGVDu7YRKe1qlKxOqjiHVTXAJN7Z_-HqDbNgSSSyKpcjBMPtn8s8T0u_7AT7y6aIFbxkY8BSaZZ1ZiHw0OCi8KvRh_lYmBL2P_7l7jr4n9QaMh58KhiZVTIbQize8M3hnEKjT2riKzMlIOS7ly9a-DwrL2zOoWlWklC51RKfs9hIjqSjPW9lDDWm6H1bivbtC5MtnuAktF4ix1Gnp_L1nxtkEVnNzjs0o7ic672h3AGzjO_Q3uSNiw"></script> <script src="//resources.bio-techne.com/bio-techne-assets/css/bootstrap/js/bootstrap.bundle.min.js"></script> <script src="/sites/default/files/js/js_f9Ht4rMsmvXFlpOu9q6kVMmELiTwxkNbyS8OBAaG0m0.js?scope=footer&delta=2&language=en&theme=bio_techne_global&include=eJxtkeuSwyAIhV9I1kdykFB1aySDpNv06dc2Tad7-QV8MOcIxiLGlBuHWi4cMHEzHw8IdwgPONKoqJub0LDixuojZ7wU0e64YrdCYUHLYe2sAYlkbdb9MwFlW7XBMsSGVDu7YRKe1qlKxOqjiHVTXAJN7Z_-HqDbNgSSSyKpcjBMPtn8s8T0u_7AT7y6aIFbxkY8BSaZZ1ZiHw0OCi8KvRh_lYmBL2P_7l7jr4n9QaMh58KhiZVTIbQize8M3hnEKjT2riKzMlIOS7ly9a-DwrL2zOoWlWklC51RKfs9hIjqSjPW9lDDWm6H1bivbtC5MtnuAktF4ix1Gnp_L1nxtkEVnNzjs0o7ic672h3AGzjO_Q3uSNiw"></script> </body> </html>

CINXE.COM

Adaptive Immunity Markers | Bio-Techne