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Transient AAV Production - OXGENE
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data-target="#navigation-content"> <span class="icon-bar"></span> <span class="icon-bar"></span> <span class="icon-bar"></span> </button> </div> <div id="navigation-content" class="collapse navbar-collapse"> <ul class='hybrid_menu nav navbar-nav'><li class="dropdown li_nav_dscovery"><a class="dropdown-toggle nav_dscovery" href='/cell_therapy/default.aspx'>Cell Therapy<b class="glyphicon glyphicon-menu-down"></b></a><ul class='dropdown-menu'><li class=" li_nav_promoter_dscovery"><a class=" nav_promoter_dscovery" href='/cell_therapy/promoter_discovery.aspx'>Promoter Discovery <b class="glyphicon glyphicon-chevron-right visible-xs-inline"></b></a></li><li class=" li_nav_cart_antibody_dscovery"><a class=" nav_cart_antibody_dscovery" href='/cell_therapy/plasmids_cell_lines.aspx'>Plasmids & Cell Lines <b class="glyphicon glyphicon-chevron-right visible-xs-inline"></b></a></li><li class=" li_nav_aav_capsid_dscovery"><a class=" nav_aav_capsid_dscovery" 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li_nav_lv_packaging_producer_cell_lines"><a class=" nav_lv_packaging_producer_cell_lines" href='/gene_therapy/transient_aav_production.aspx'>Transient AAV Production</a></li><li class=" li_nav_adenoviral_production_systems"><a class=" nav_adenoviral_production_systems" href='/gene_therapy/tessa_scalable_aav_production.aspx'>TESSA: Scalable AAV Production</a></li></ul> <!--Editable Text--> <h1>TRANSIENT AAV<br /> <strong>PRODUCTION</strong></h1> <p class="lg_p">Our industry leading technology platform provides flexible, high titre rAAV production. Reconfigured Rep-Cap and modified Ad5 helper plasmids and GMP banked clonal suspension HEK293 cell line improve AAV yield and quality.</p> <!--/Editable Text--> </div> <div class="container-fluid"> <!--Editable Text--> <section class="img_divider_widget"> <div class="img_divider_image"> <div class="container"> <p><img src="/_userfiles/pages/images/lab_photos/oxford_genetics_rgr_094.jpg" style="width: 70%; height: 70%;" /></p> </div> </div> <div class="img_divider_content"> <div class="container"> <h2 class="alternative">"OXGENE's AAV system is superior to<br /> off-the-shelf plasmid systems for AAV titres"</h2> <h3 style="text-align: right;"><br /> Andy Topping, Chief Scientific Officer at FUJIFILM Diosynth<br /> Biotechnologies</h3> </div> </div> </section> <section class="paragraph_widget"> <div class="container"> <h3>Transient AAV Production</h3> <p class="lg_p">Our transient expression platform comprises optimised proprietary AAVEX™ plasmids and a GMP-banked clonal suspension HEK293 cell line. We have reconfigured the Rep and Cap genes to place Cap under the control of a strong CMV promoter, while Rep is expressed at a lower level via an EMCV internal ribosome entry site. This results in a higher viral titre, better per cell rAAV productivity and improved full:empty vector ratio. We've also improved adenoviral helper functionality by simplifying the Ad5 helper plasmid, which doesn't contain any adenoviral <em>hexon</em> genes; an added benefit when it comes to regulatory approval.</p> <p class="lg_p">We offer expert cloning and engineering services to customise and optimise our AAVEX™ plasmids for expression of your gene of interest, before process development and manufacture of your rAAV vectors at any grade and scale.</p> </div> </section> <div class="editable_expandable spacer"> <div aria-expanded="false" class="expandable_heading collapsed" data-target="#panel169" data-toggle="collapse"> <h4 class="expandable_title">Reconfigured Rep-Cap improves viral titre by two to eight fold</h4> </div> <div aria-expanded="false" class="expandable_collapse collapse" id="panel169" style="height: 0px;"> <div class="expandable_body"> <p style="text-align: center;"><img alt="" src="/_userfiles/pages/images/gene_therapy/aav101.png" style="width: 100%;" /><img alt="" src="/_userfiles/pages/images/gene_therapy/aav101_600x455.png" style="width: 600px; height: 455px;" /></p> <p>rAAV production in suspension HEK293 cell line in shake flasks. Using OXGENE’s reconfigured Rep-Cap plasmid (red) improves viral titre between two and eight fold, depending on AAV serotype.</p> </div> </div> <div class="clearer"> </div> </div> <div class="editable_expandable spacer"> <div aria-expanded="false" class="expandable_heading collapsed" data-target="#panel163" data-toggle="collapse"> <h4 class="expandable_title">Reconfiguration improves particle infectivity</h4> </div> <div aria-expanded="false" class="expandable_collapse collapse" id="panel163" style="height: 0px;"> <div class="expandable_body"> <p style="text-align: center;"><img alt="" src="/_userfiles/pages/images/gene_therapy/aav_plasmids_reconfiguration_improves_particle_infectivity.png" style="width: 80%; height: 80%;" /></p> <p>rAAV5 made using standard plasmids (left) infects HEK293 cells less efficiently than rAAV5 made using OXGENE's reconfigured RepCap plasmid (right).</p> </div> </div> <div class="clearer"> </div> </div> <div class="editable_expandable spacer"> <div aria-expanded="false" class="expandable_heading collapsed" data-target="#panel164" data-toggle="collapse"> <h4 class="expandable_title">Reconfiguration improves packaging efficiency</h4> </div> <div aria-expanded="false" class="expandable_collapse collapse" id="panel164" style="height: 0px;"> <div class="expandable_body"> <p style="text-align: center;"><img alt="" src="/_userfiles/pages/images/gene_therapy/aav_plasmids_reconfiguration_improves_packaging_efficiency.png" style="width: 80%; height: 80%;" /></p> <p>Third party evaluation of OXGENE's AAV5 plasmids using four different HEK293 cell lines. Highest and lowest results reported. VG titrated by ddPCR, physical particles by capsid ELISA.</p> </div> </div> <div class="clearer"> </div> </div> <p> </p> <section class="divider_widget blue"> <div class="container"> <div class="left_col"> <h2 class="alternative">From our experts to yours; we offer comprehensive<br /> technical support so you can have complete<br /> confidence in our technologies.</h2> </div> <div class="right_col"> <p style="text-align: right;"><a class="blue_btn" href="/about/contact/business_development_enquiry.aspx">CONTACT US</a></p> </div> </div> </section> <p> </p> <section class="divider_widget grey"> <div class="container"> <div class="left_col"> <h2 class="alternative">TESSA™: Scalable AAV Production</h2> <p>High-titre, high quality, plasmid-free AAV production.</p> </div> <div class="right_col"> <p style="text-align: right;"><a class="orange_btn" href="/gene_therapy/tessa_scalable_aav_production.aspx">READ NEXT</a></p> </div> </div> </section> <!--/Editable Text--> </div> </article> 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document.all["ctl25_RFVFirstName"] : document.getElementById("ctl25_RFVFirstName"); ctl25_RFVFirstName.controltovalidate = "ctl25_TBFirstName"; ctl25_RFVFirstName.errormessage = "Please enter your first name"; ctl25_RFVFirstName.display = "Dynamic"; ctl25_RFVFirstName.validationGroup = "leads"; ctl25_RFVFirstName.evaluationfunction = "RequiredFieldValidatorEvaluateIsValid"; ctl25_RFVFirstName.initialvalue = ""; var ctl25_RFVLastName = document.all ? document.all["ctl25_RFVLastName"] : document.getElementById("ctl25_RFVLastName"); ctl25_RFVLastName.controltovalidate = "ctl25_TBLastName"; ctl25_RFVLastName.errormessage = "Please enter your last name"; ctl25_RFVLastName.display = "Dynamic"; ctl25_RFVLastName.validationGroup = "leads"; ctl25_RFVLastName.evaluationfunction = "RequiredFieldValidatorEvaluateIsValid"; ctl25_RFVLastName.initialvalue = ""; var ctl25_RFVCompany = document.all ? document.all["ctl25_RFVCompany"] : document.getElementById("ctl25_RFVCompany"); ctl25_RFVCompany.controltovalidate = "ctl25_TBCompany"; ctl25_RFVCompany.errormessage = "Please enter your company name"; ctl25_RFVCompany.display = "Dynamic"; ctl25_RFVCompany.validationGroup = "leads"; ctl25_RFVCompany.evaluationfunction = "RequiredFieldValidatorEvaluateIsValid"; ctl25_RFVCompany.initialvalue = ""; var ctl25_RFVEmail = document.all ? document.all["ctl25_RFVEmail"] : document.getElementById("ctl25_RFVEmail"); ctl25_RFVEmail.controltovalidate = "ctl25_TBEmail"; ctl25_RFVEmail.errormessage = "Please enter your email address"; ctl25_RFVEmail.display = "Dynamic"; ctl25_RFVEmail.validationGroup = "leads"; ctl25_RFVEmail.evaluationfunction = "RequiredFieldValidatorEvaluateIsValid"; ctl25_RFVEmail.initialvalue = ""; var ctl25_REVEmail = document.all ? document.all["ctl25_REVEmail"] : document.getElementById("ctl25_REVEmail"); ctl25_REVEmail.controltovalidate = "ctl25_TBEmail"; ctl25_REVEmail.errormessage = "<span class=\'help-block\'>Invalid email address</span>"; ctl25_REVEmail.display = "Dynamic"; ctl25_REVEmail.validationGroup = "leads"; ctl25_REVEmail.evaluationfunction = "RegularExpressionValidatorEvaluateIsValid"; ctl25_REVEmail.validationexpression = "^\\w+([-+.\']\\w+)*@\\w+([-.]\\w+)*\\.\\w+([-.]\\w+)*$"; var ctl25_RFVLocation = document.all ? document.all["ctl25_RFVLocation"] : document.getElementById("ctl25_RFVLocation"); ctl25_RFVLocation.controltovalidate = "ctl25_DDLLocation"; ctl25_RFVLocation.errormessage = "Please select your location"; ctl25_RFVLocation.display = "Dynamic"; ctl25_RFVLocation.validationGroup = "leads"; ctl25_RFVLocation.evaluationfunction = "RequiredFieldValidatorEvaluateIsValid"; ctl25_RFVLocation.initialvalue = ""; var ctl25_ctl01_BotCheckBoxValidator = document.all ? document.all["ctl25_ctl01_BotCheckBoxValidator"] : document.getElementById("ctl25_ctl01_BotCheckBoxValidator"); ctl25_ctl01_BotCheckBoxValidator.errormessage = "Please uncheck this box to continue"; ctl25_ctl01_BotCheckBoxValidator.validationGroup = "leads"; ctl25_ctl01_BotCheckBoxValidator.evaluationfunction = "CustomValidatorEvaluateIsValid"; ctl25_ctl01_BotCheckBoxValidator.clientvalidationfunction = "validateCheckboxctl25_ctl01_CBBot"; var ctl25_ctl01_BotValidator = document.all ? document.all["ctl25_ctl01_BotValidator"] : document.getElementById("ctl25_ctl01_BotValidator"); ctl25_ctl01_BotValidator.validationGroup = "leads"; ctl25_ctl01_BotValidator.evaluationfunction = "CustomValidatorEvaluateIsValid"; //]]> </script> <script type="text/javascript"> //<![CDATA[ var Page_ValidationActive = false; if (typeof(ValidatorOnLoad) == "function") { ValidatorOnLoad(); } function ValidatorOnSubmit() { if (Page_ValidationActive) { return ValidatorCommonOnSubmit(); } else { return true; } } //]]> </script> </form> <script src="/_resources/js/master/master.min.v20220920171055.js" type="text/javascript"></script> <script src="/_resources/js/include_masterpage.min.v20210903123328.js" type="text/javascript"></script> <!-- The Bootstrap Image Gallery lightbox, should be a child element of the document body --> <div id="blueimp-gallery" class="blueimp-gallery"> <!-- The container for the modal slides --> <div class="slides"></div> <!-- Controls for the borderless lightbox --> <h3 class="title"></h3> <a class="prev">‹</a> <a class="next">›</a> <a class="close">×</a> <a class="play-pause"></a> <ol class="indicator"></ol> <!-- The modal dialog, which will be used to wrap the lightbox content --> <div class="modal fade"> <div class="modal-dialog"> <div class="modal-content"> <div class="modal-header"> <button type="button" class="close" aria-hidden="true">×</button> <h4 class="modal-title"></h4> </div> <div class="modal-body next"></div> <div class="modal-footer"> <button type="button" class="btn btn-default pull-left prev"> <i class="glyphicon glyphicon-chevron-left"></i> Previous </button> <button type="button" class="btn btn-primary next"> Next <i class="glyphicon glyphicon-chevron-right"></i> </button> </div> </div> </div> </div> </div> </body> </html>