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lupeol</title> <meta name="description" content="Search results for: lupeol"> <meta name="keywords" content="lupeol"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" 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class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="lupeol"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 11</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: lupeol</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> Antibacterial and Antityrosinase Activity of Isolated Compounds from Stem Bark of Ficus platyphylla Del</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Aminu%20Muhammad">Aminu Muhammad</a>, <a href="https://publications.waset.org/abstracts/search?q=Mustapha%20Ya%E2%80%99u"> Mustapha Ya’u</a>, <a href="https://publications.waset.org/abstracts/search?q=Hasnah%20Mohd%20Sirat"> Hasnah Mohd Sirat</a> </p> <p class="card-text"><strong>Abstract:</strong></p> An investigation of the chemical constituents into the stem bark of Ficus platyphylla (Moraceae) has resulted in the isolation of hordenine, epicatechin, lupeol, lupeol acetate and α-amyrin acetate. Their structures were determined using spectroscopic data as well as comparison with literature data. The antibacterial assay has been tested against Gram positive and Gram negative bacteria, while the tyrosinase inhibition assay was examined using L-Dopa as a substrate of mushroom tyrosinase enzyme. hordenine, epicatechin, lupeol, lupeol acetate and α-amyrin acetate showed minimum inhibition concentration (MIC) values in the range of 225-900 µg/mL against the bacterial strains. Lupeol, lupeol acetate and α-amyrin acetate showed significant antityrosinase activity against mushroom tyrosinase enzyme with percent inhibition of 67.7%, 66.2% and 62.2%, respectively. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antibacterial" title="antibacterial">antibacterial</a>, <a href="https://publications.waset.org/abstracts/search?q=antityrosinase" title=" antityrosinase"> antityrosinase</a>, <a href="https://publications.waset.org/abstracts/search?q=chemical%20constituents" title=" chemical constituents"> chemical constituents</a>, <a href="https://publications.waset.org/abstracts/search?q=Ficus%20platyphylla" title=" Ficus platyphylla"> Ficus platyphylla</a> </p> <a href="https://publications.waset.org/abstracts/46753/antibacterial-and-antityrosinase-activity-of-isolated-compounds-from-stem-bark-of-ficus-platyphylla-del" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/46753.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">268</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> Beneficial Effect of Lupeol in Diabetes Induced Oxidative Damage</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rajnish%20Gupta">Rajnish Gupta</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20S.%20Gupta"> R. S. Gupta</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Present research was aimed to investigate antidiabetic and antioxidant status of Lupeol in streptozotocin induced diabetes. Rats were divided into following groups mainly: control, diabetic, normal group as well as diabetic treated with Lupeol at 25 and 35 mg/kg b.wt./day for 21 days, diabetic group treated with glibenclamide. Tissue (pancreas, kidney and liver) as well as serum biochemical parameters were analysed for any abnormal behavior. Lupeol administration reduced diabetes onset with significant improvement in serum insulin level also strengthened by increase in β-Cell counts. A significant decrease was observed in serum glucose level. Furthermore, Lupeol treatment increased the antioxidant enzymes, glycolytic enzymes and also protein levels with a decrease in the level of thiobarbituric acid-reactive oxygen species and gluconeogenic enzymes. Present study proves that Lupeol administration significantly reinstated serum and tissue biochemical parameters and thus strengthening its antidiabetic potential. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=oxidative%20stress" title="oxidative stress">oxidative stress</a>, <a href="https://publications.waset.org/abstracts/search?q=pterostilbene" title=" pterostilbene"> pterostilbene</a>, <a href="https://publications.waset.org/abstracts/search?q=thiobarbituric%20acid" title=" thiobarbituric acid"> thiobarbituric acid</a>, <a href="https://publications.waset.org/abstracts/search?q=reactive%20oxygen%20species" title=" reactive oxygen species"> reactive oxygen species</a> </p> <a href="https://publications.waset.org/abstracts/14774/beneficial-effect-of-lupeol-in-diabetes-induced-oxidative-damage" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/14774.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">471</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> In-Silico Evaluation and Antihyperglycemic Potential of Leucas Cephalotes </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anjali%20Verma">Anjali Verma</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahesh%20Pal"> Mahesh Pal</a>, <a href="https://publications.waset.org/abstracts/search?q=Veena%20Pande"> Veena Pande</a>, <a href="https://publications.waset.org/abstracts/search?q=Dalip%20Kumar%20Upreti"> Dalip Kumar Upreti</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study is carried out to explore the anti-hyperglycemic activity of Leucas cephalotes plant parts. A fruit, leaves, stems, and roots part of the Leucas cephalotes has been extracted in ethanol and have been evaluated for anti-hyperglycemic activity. The present study indicated that, ethanolic extract of fruit and leaves have shown significant α- amylase inhibitory activity with IC50 value of 92.86 ± 0.89 μg/mL and 98.09 ± 0.69 μg/mL respectively. Two known compounds β-sitosterol and lupeol were isolated from ethanolic extract of L. cephalotes leaves and were subjected to anti-hyperglycemic activity. Lupeol shows the best activity with IC50 55.73 ± 0.47 μg/mL and the results were verified by docking study of these compounds with mammalian α-amylase was carried out on its active site. It was concluded from the study that β-sitosterol and lupeol form one H-bond interactions with the active site residues either Asp212 or Thr21. The estimated free energy binding of β-sitosterol was found to be -9.47 kcal mol-1 with an estimated inhibition constant (Ki) of 558.94 nmol whereas the estimated free energy binding of lupeol was -11.73 kcal mol-1 with an estimated inhibition constant (Ki) of 476.71pmmol. The present study clearly showed that lupeol is more potent in comparison to β-sitosterol. The study indicates that L. cephalotes have significant potential to inhibit α-amylase enzyme. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=alpha-amylase" title="alpha-amylase">alpha-amylase</a>, <a href="https://publications.waset.org/abstracts/search?q=beta-sitosterol" title=" beta-sitosterol"> beta-sitosterol</a>, <a href="https://publications.waset.org/abstracts/search?q=hyperglycemia" title=" hyperglycemia"> hyperglycemia</a>, <a href="https://publications.waset.org/abstracts/search?q=lupeol" title=" lupeol"> lupeol</a> </p> <a href="https://publications.waset.org/abstracts/57898/in-silico-evaluation-and-antihyperglycemic-potential-of-leucas-cephalotes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/57898.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">211</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> HPTLC Based Qualitative and Quantitative Evaluation of Uraria picta Desv: A Dashmool Species</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hari%20O.%20Saxena">Hari O. Saxena</a>, <a href="https://publications.waset.org/abstracts/search?q=Ganesh"> Ganesh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the present investigation, chemical fingerprints of methanolic extracts of roots, stem and leaves of Uraria picta were developed using HPTLC technique. These fingerprints will be useful for authentication as well as in differentiating the species from adulterants. These will also serve as a biochemical marker for this valuable species in pharmaceutical industries and plant systemic studies. Roots, stem and leaves of Uraria picta were further evaluated for quantification of an active ingredient lupeol to find out alternatives to roots. Results showed more content of lupeol in stem (0.048%, dry wt.) as compare to roots (0.017%, dry wt.) suggesting the utilization of stem in place of roots. It will avoid uprooting of this prestigious plant which ultimately will promote its conservation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chemical%20fingerprints" title="chemical fingerprints">chemical fingerprints</a>, <a href="https://publications.waset.org/abstracts/search?q=lupeol" title=" lupeol"> lupeol</a>, <a href="https://publications.waset.org/abstracts/search?q=quantification" title=" quantification"> quantification</a>, <a href="https://publications.waset.org/abstracts/search?q=Uraria%20picta" title=" Uraria picta"> Uraria picta</a> </p> <a href="https://publications.waset.org/abstracts/54865/hptlc-based-qualitative-and-quantitative-evaluation-of-uraria-picta-desv-a-dashmool-species" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/54865.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">257</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Characterization of Triterpenoids Antimicrobial Potential in Ethyl Acetate Extracts from Aerial Parts of Deinbollia Pinnata</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rufai%20Yakubu%20And%20Suleiman%20Kabiru">Rufai Yakubu And Suleiman Kabiru</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Triterpenoids are a diverse class of secondary metabolites with potential antimicrobial properties. In this study, the crude extracts from ethyl acetate was obtained with ultrasonic extraction method. Using a combined chromatographic separation method to isolate squalene (1) stigmasterol (2), stigmasta-5,22-diene-3-ol acetate (3), γ-sitosterol (4), lupeol (5), taraxasterol (6), and betulinic acid (7) from ethyl acetate extracts. Ethyl acetate crude extracts and isolated compounds were both screened for antimicrobial activity and minimum inhibitory concentration (MIC). For ethyl acetate crude extracts with concentrations of (1.5, 0.75, 0.35, & 0.168 mg/mL) indicated marginal antibacterial activity with a range of 17, 20 and 14 mm zone of inhibition for Staphylococcus aureus, Escherichia coli and Candida albicans and lower minimum inhibitory concentrations ranges from 18.75 µg/ml to 150 µg/mL. Butulinic acid showed the highest activity against E. coli and C. albicans at 15 mm and 15 mm followed by Lupeol against S. aureus, E. coli and C. albicans at 13, 12, 12 mm. Moreso, no antimicrobial activity for both S. aureus and C. albicans with squalene except for E. coli which showed activity at 11 mm with 300 µg/mL (MIC). Thus, abundant triterpenoids in Deinbollia pinnata will be another centered area for antimicrobial drug discovery. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=triterpenoid" title="triterpenoid">triterpenoid</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20potentials" title=" antimicrobial potentials"> antimicrobial potentials</a>, <a href="https://publications.waset.org/abstracts/search?q=deinbollia%20pinnata" title=" deinbollia pinnata"> deinbollia pinnata</a>, <a href="https://publications.waset.org/abstracts/search?q=aerial%20parts" title=" aerial parts"> aerial parts</a> </p> <a href="https://publications.waset.org/abstracts/180660/characterization-of-triterpenoids-antimicrobial-potential-in-ethyl-acetate-extracts-from-aerial-parts-of-deinbollia-pinnata" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/180660.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">70</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Possible Modulation of FAS and PTP-1B Signaling in Ameliorative Potential of Bombax ceiba against High Fat Diet Induced Obesity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Paras%20Gupta">Paras Gupta</a>, <a href="https://publications.waset.org/abstracts/search?q=Rohit%20Goyal"> Rohit Goyal</a>, <a href="https://publications.waset.org/abstracts/search?q=Yamini%20Chauhan"> Yamini Chauhan</a>, <a href="https://publications.waset.org/abstracts/search?q=Pyare%20Lal%20Sharma"> Pyare Lal Sharma</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Bombax ceiba Linn., commonly called as Semal, is used in various gastro-intestinal disturbances. It contains lupeol which inhibits PTP-1B, adipogenesis, TG synthesis and accumulation of lipids in adipocytes and adipokines whereas the flavonoids isolated from B. ceiba has FAS inhibitory activity. The present study was aimed to investigate ameliorative potential of Bombax ceiba to experimental obesity in Wistar rats, and its possible mechanism of action. Methods: Male Wistar albino rats weighing 180–220 g were employed in present study. Experimental obesity was induced by feeding high fat diet for 10 weeks. Methanolic extract of B. ceiba extract 100, 200 and 400 mg/kg and Gemfibrozil 50 mg/kg as standard drug were given orally from 7th to 10th week. Results: Induction with HFD for 10 weeks caused significant (p < 0.05) increase in % body wt, BMI, LEE indices; serum glucose, triglyceride, LDL, VLDL, cholesterol, free fatty acid, ALT, AST; tissue TBARS, nitrate/nitrite levels; different fat pads and relative liver weight; and significant decrease in food intake (g and kcal), serum HDL and tissue glutathione levels in HFD control rats. Treatment with B. ceiba extract and Gemfibrozil significantly attenuated these HFD induced changes, as compared to HFD control. The effect of B. ceiba 200 and 400 mg/kg was more pronounced in comparison to Gemfibrozil. Conclusion: On the basis of results obtained, it may be concluded that the methanolic extract of stem bark of Bombax ceiba has significant ameliorative potential against HFD induced obesity in rats, possibly through modulation of FAS and PTP-1B signaling due to the presence of flavonoids and lupeol. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=obesity" title="obesity">obesity</a>, <a href="https://publications.waset.org/abstracts/search?q=Bombax%20ceiba" title=" Bombax ceiba"> Bombax ceiba</a>, <a href="https://publications.waset.org/abstracts/search?q=free%20fatty%20acid" title=" free fatty acid"> free fatty acid</a>, <a href="https://publications.waset.org/abstracts/search?q=protein%20tyrosine%20phosphatase-1B" title=" protein tyrosine phosphatase-1B"> protein tyrosine phosphatase-1B</a>, <a href="https://publications.waset.org/abstracts/search?q=fatty%20acid%20synthase" title=" fatty acid synthase"> fatty acid synthase</a> </p> <a href="https://publications.waset.org/abstracts/9263/possible-modulation-of-fas-and-ptp-1b-signaling-in-ameliorative-potential-of-bombax-ceiba-against-high-fat-diet-induced-obesity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9263.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">400</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Studying Medicinal Plants of Rajasthan Used by Tribes for Different Diseases</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rekha%20Vijayvergia">Rekha Vijayvergia</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Around seven percent of tribal population of India lives in Rajasthan. Rajasthan has rich cultural diversity and biodiversity. Ethno-botany can be defined as the total natural and traditional relationship and the interactions between man and his surrounding plant wealth from times immemorial, due to sheer, necessity, intuition, observation, and experimentation. Medicinal plants are valuable and are used for the production of various drugs. These plants produce a high diversity of natural products or secondary metabolites like Mahanimbicine, Andrographine, murrayaline, lupeol, and limonin etc. with a prominent function in the protection against diseases like diabetes, kidney stones, osteoporosis, tumours, opthalmia, leucorrhoea, bronchial asthma, diarrhea, cancer, etc. The present report gives an account of traditional medicinal uses of common medicinal plants of Rajasthan. A total of 18 plant species belonging to 13 families are reported, that are being used for various purposes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ethno%20botany" title="ethno botany">ethno botany</a>, <a href="https://publications.waset.org/abstracts/search?q=Rajasthan" title=" Rajasthan"> Rajasthan</a>, <a href="https://publications.waset.org/abstracts/search?q=secondary%20metabolites" title=" secondary metabolites"> secondary metabolites</a>, <a href="https://publications.waset.org/abstracts/search?q=traditional%20medicines" title=" traditional medicines"> traditional medicines</a> </p> <a href="https://publications.waset.org/abstracts/23738/studying-medicinal-plants-of-rajasthan-used-by-tribes-for-different-diseases" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/23738.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">491</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Cytotoxic Terpenes from the Stems of Bark of Echinacea Angustifolia DC Collected from Girei, Adamawa State, Nigeria</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abdu%20Zakari">Abdu Zakari</a>, <a href="https://publications.waset.org/abstracts/search?q=Said%20Jibrin"> Said Jibrin</a>, <a href="https://publications.waset.org/abstracts/search?q=Fatope%20Majekodunmi%20Oladeji"> Fatope Majekodunmi Oladeji</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammed%20Hassan%20Shagga"> Mohammed Hassan Shagga</a>, <a href="https://publications.waset.org/abstracts/search?q=Andrew%20Sule"> Andrew Sule</a> </p> <p class="card-text"><strong>Abstract:</strong></p> From the Stems of Bark of Echinaceae angustifolia DC three known triterpenes 3a,5,5b,8,8,11a-hexamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysene-9-yl acetate (lupeol acetate), 4,4,6a,6b,8a,10,11,14b,octamethyl1,1,2,3,4,4a,5,6,6a,6b,7,8,8a, 9,10, 11,12,12a,14,14a,14b-icosahydropicen-3-yl acetate (derivative of β-amyrin and 9- hydroxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysene- 3a-carboxylic acid (betulinic acid), labelled as Ea-7-38, Ea-9-10 and Ea-12-85) were isolated and characterized. All isolates were tested for their cytotoxicities against Artemia salina (brine shrimp larvae). Compound Ea-12-85 exhibited potent cytotoxic activity against the Artemia salina, Ea-7-38, Ea-9-10 were found to be non-toxic in the cytotoxicity test. The result of the study has justified the claim of the traditional medicine practitioners in Girei for the treatment of complicated malaria disease using the stem bark of E. angustifolia DC. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cytotoxic" title="cytotoxic">cytotoxic</a>, <a href="https://publications.waset.org/abstracts/search?q=terpenes" title=" terpenes"> terpenes</a>, <a href="https://publications.waset.org/abstracts/search?q=Echinaceae%20angustifolia" title=" Echinaceae angustifolia"> Echinaceae angustifolia</a>, <a href="https://publications.waset.org/abstracts/search?q=brine%20shrimp" title=" brine shrimp"> brine shrimp</a>, <a href="https://publications.waset.org/abstracts/search?q=artemia%20salina" title=" artemia salina"> artemia salina</a> </p> <a href="https://publications.waset.org/abstracts/179010/cytotoxic-terpenes-from-the-stems-of-bark-of-echinacea-angustifolia-dc-collected-from-girei-adamawa-state-nigeria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/179010.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">69</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> A Review on Future of Plant Based Medicine in Treatment of Urolithiatic Disorder</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gopal%20Lamichhane">Gopal Lamichhane</a>, <a href="https://publications.waset.org/abstracts/search?q=Biswash%20Sapkota"> Biswash Sapkota</a>, <a href="https://publications.waset.org/abstracts/search?q=Grinsun%20Sharma"> Grinsun Sharma</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahendra%20Adhikari"> Mahendra Adhikari</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Urolithiasis is a condition in which insoluble or less soluble salts like oxalate, phosphate etc. precipitate in urinary tract and causes obstruction in ureter resulting renal colic or sometimes haematuria. It is the third most common disorder of urinary tract affecting nearly 2% of world’s population. Poor urinary drainage, microbial infection, oxalate and calcium containing diet, calciferol, hyperparathyroidism, cysteine in urine, gout, dysfunction of intestine, drought environment, lifestyle, exercise, stress etc. are risk factors for urolithiasis. Wide ranges of treatments are available in allopathic system of medicine but reoccurrence is unpreventable even with the surgical removal of stone or lithotripsy. So, people prefer alternative medicinal systems such as Unani, homeopathic, ayurvedic etc. systems of medicine due to their fewer side effects over allopathic counterpart. Different plants based ethnomedicines are being well established by their continuous effective use in human since long time in treatment of urinary problem. Many studies have scientifically proved those ethnomedicines for antiurolithiatic effect in animal and in vitro model. Plant-based remedies were found to be therapeutically effective for both prevention as well as cure of calcium oxalate urolithiasis. Plants were known to show these effects through a combination of many effects such as antioxidant, diuretic, hypocalciuric, urine alkalinizing effect in them. Berberine, triterpenoids, lupeol are the phytochemicals established for antiurolithiatic effect. Hence, plant-based medicine can be the effective herbal alternative as well as means of discovery of novel drug molecule for curing urolithiatic disorder and should be focused on further research to discover their value in coming future. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=urolithiasis" title="urolithiasis">urolithiasis</a>, <a href="https://publications.waset.org/abstracts/search?q=herbal%20medicine" title=" herbal medicine"> herbal medicine</a>, <a href="https://publications.waset.org/abstracts/search?q=ethnomedicine" title=" ethnomedicine"> ethnomedicine</a>, <a href="https://publications.waset.org/abstracts/search?q=kidney%20stone" title=" kidney stone"> kidney stone</a>, <a href="https://publications.waset.org/abstracts/search?q=calcium%20oxalate" title=" calcium oxalate"> calcium oxalate</a> </p> <a href="https://publications.waset.org/abstracts/76469/a-review-on-future-of-plant-based-medicine-in-treatment-of-urolithiatic-disorder" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/76469.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">274</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Antimicrobial Action and Its Underlying Mechanism by Methanolic Seed Extract of Syzygium cumini on Bacillus subtilis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alok%20Kumar%20Yadav">Alok Kumar Yadav</a>, <a href="https://publications.waset.org/abstracts/search?q=Saurabh%20Saraswat"> Saurabh Saraswat</a>, <a href="https://publications.waset.org/abstracts/search?q=Preeti%20Sirohi"> Preeti Sirohi</a>, <a href="https://publications.waset.org/abstracts/search?q=Manjoo%20Rani"> Manjoo Rani</a>, <a href="https://publications.waset.org/abstracts/search?q=Sameer%20Srivastava"> Sameer Srivastava</a>, <a href="https://publications.waset.org/abstracts/search?q=Manish%20Pratap%20Singh"> Manish Pratap Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=Nand%20K.%20Singh"> Nand K. Singh </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The development of antibiotic resistance in bacteria is increasing at an alarming rate, and this is considered as one of the most serious threats in the history of medicine, and an alternative solution should be derived so as to tackle this problem. In many countries, people use the medicinal plants for the treatment of various diseases as these are cheaper, easily available and least toxic. Syzygium cumini is used for the treatment of various kinds of diseases but their mechanism of action is not reported. The antimicrobial activity of Syzygium cumini was tested by the well diffusion assay and zone of inhibition was reported to be 20.06 mm as compared to control with MIC of 0.3 mg/ml. Genomic DNA fragmentation of Bacillus subtilis revealed apoptosis and FE-SEM indicate cell wall cracking on several intervals of time. Propidium iodide staining results showed that few bacterial cells were stained in the control and population of stained cells increase after exposing them for various period of time. Flow cytometric kinetic data analysis on the membrane permeabilization in bacterial cell showed the significant contribution of antimicrobial potential of the seed extract on antimicrobial-induced permeabilization. Two components of Syzygium cumini methanolic seed extract was found to be quite active against four enzymes like PDB ID- 1W5D, 4OX3, 3MFD and 5E2F which have a very crucial role in membrane synthesis in Bacillus subtilis by in silico analysis. Through in silico analysis, lupeol showed highest binding energy for macromolecule 1W5D and 4OX3 whereas stigmasterol showed the highest binding energy for macromolecule 3MFD and 5E2F respectively. It showed that methanolic seed extract of Syzygium cumini can be used for the inhibition of foodborne infections caused by Bacillus subtilis and also as an alternative of prevalent antibiotics. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antibiotics" title="antibiotics">antibiotics</a>, <a href="https://publications.waset.org/abstracts/search?q=Bacillus%20subtilis" title=" Bacillus subtilis"> Bacillus subtilis</a>, <a href="https://publications.waset.org/abstracts/search?q=inhibition" title=" inhibition"> inhibition</a>, <a href="https://publications.waset.org/abstracts/search?q=Syzygium%20cumini" title=" Syzygium cumini"> Syzygium cumini</a> </p> <a href="https://publications.waset.org/abstracts/85752/antimicrobial-action-and-its-underlying-mechanism-by-methanolic-seed-extract-of-syzygium-cumini-on-bacillus-subtilis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85752.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">199</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Chemical and Biological Studies of Kielmeyera coriacea Mart. (Calophyllaceae) Based on Ethnobotanical Survey of Rural Community from Brazil</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vanessa%20G.%20P.%20Severino">Vanessa G. P. Severino</a>, <a href="https://publications.waset.org/abstracts/search?q=Eliangela%20Cristina%20Candida%20Costa"> Eliangela Cristina Candida Costa</a>, <a href="https://publications.waset.org/abstracts/search?q=Nubia%20Alves%20Mariano%20Teixeira%20Pires%20Gomides"> Nubia Alves Mariano Teixeira Pires Gomides</a>, <a href="https://publications.waset.org/abstracts/search?q=Lucilia%20Kato"> Lucilia Kato</a>, <a href="https://publications.waset.org/abstracts/search?q=Afif%20Felix%20Monteiro"> Afif Felix Monteiro</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Anita%20Lemos%20Vasconcelos%20Ambrosio"> Maria Anita Lemos Vasconcelos Ambrosio</a>, <a href="https://publications.waset.org/abstracts/search?q=Carlos%20Henrique%20Gomes%20Martins"> Carlos Henrique Gomes Martins</a> </p> <p class="card-text"><strong>Abstract:</strong></p> One of the biomes present in Brazil is known as Cerrado, which is a vast tropical savanna ecoregion, particularly in the states of Goiás, Mato Grosso do Sul, Mato Grosso, Tocantins and Minas Gerais. Many species of plants are characterized as endemic and they have therapeutic value for a large part of the population, especially to the rural communities. Given that, the southeastern region of the state of Goiás contains about 21 rural communities, which present a form of organization based on the use of natural resources available. One of these rural communities is named of Coqueiros, where the knowledge about the medicinal plants was very important to this research. Thus, this study focuses on the ethnobotanical survey of this community on the use of Kielmeyera coriacea to treat diseases. From the 37 members interviewed, 76% indicated this species for the treatment of intestinal infection, leukemia, anemia, gastritis, gum pain, toothache, cavity, arthritis, arthrosis, healing, vermifuge, rheumatism, antibiotic, skin problems, mycoses and all kinds of infections. The medicinal properties attributed during the interviews were framed in the body system (disease categories), adapted from ICD 10; thus, 20 indications of use were obtained, among five body systems. Therefore, the root of this species was select to chemical and biological (antioxidant and antimicrobial) studies. From the liquid-liquid extraction of ethanolic extract of root (EER), the hexane (FH), ethyl acetate (FAE), and hydro alcoholic (FHA) fractions were obtained. The chemical profile study of these fractions was performed by LC-MS, identifying major compounds such as δ-tocotrienol, prenylated acylphoroglucinol, 2-hydroxy-1-methoxyxanthone and quercitrin. EER, FH, FAE and FHA were submitted to biological tests. FHA presented the best antioxidant action (EC50 201.53 μg mL-1). EER inhibited the bacterial growth of Streptococcus pyogenes and Pseudomonas aeruginosa, microorganisms associated with rheumatism, at Minimum Inhibitory Concentration (MIC) of 6.25 μg mL-1. In addition, the FH-10 subfraction, obtained from FH fractionation, presented MIC of 1.56 μg mL-1 against S. pneumoniae; EER also inhibited the fungus Candida glabrata (MIC 7.81 μg mL- 1). The FAE-4.7.3 fraction, from the fractionation of FAE, presented MIC of 200 μg mL-1 against Lactobacillus casei, which is one of the causes of caries and oral infections. By the correlation of the chemical and biological data, it is possible to note that the FAE-4.7.3 and FH-10 are constituted 4-hydroxy-2,3-methylenedioxy xanthone, 3-hydroxy-1,2-dimethoxy xanthone, lupeol, prenylated acylphoroglucinol and quercitrin, which could be associated with the biological potential found. Therefore, this study provides an important basis for further investigations regarding the compounds present in the active fractions of K. coriacea, which will permit the establishment of a correlation between ethnobotanical survey and bioactivity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biological%20activity" title="biological activity">biological activity</a>, <a href="https://publications.waset.org/abstracts/search?q=ethnobotanical%20survey" title=" ethnobotanical survey"> ethnobotanical survey</a>, <a href="https://publications.waset.org/abstracts/search?q=Kielmeyera%20coriacea%20Mart." title=" Kielmeyera coriacea Mart."> Kielmeyera coriacea Mart.</a>, <a href="https://publications.waset.org/abstracts/search?q=LC-MS%20profile" title=" LC-MS profile"> LC-MS profile</a> </p> <a href="https://publications.waset.org/abstracts/96109/chemical-and-biological-studies-of-kielmeyera-coriacea-mart-calophyllaceae-based-on-ethnobotanical-survey-of-rural-community-from-brazil" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/96109.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">141</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th 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