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style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Carlos Tres</h3></div><div class="js-work-strip profile--work_container" data-work-id="122938147"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122938147/Prenatal_Ozone_Exposure_Induces_Memory_Deficiencies_in_Newborns_Rats"><img alt="Research paper thumbnail of Prenatal Ozone Exposure Induces Memory Deficiencies in Newborns Rats" class="work-thumbnail" src="https://attachments.academia-assets.com/117493379/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122938147/Prenatal_Ozone_Exposure_Induces_Memory_Deficiencies_in_Newborns_Rats">Prenatal Ozone Exposure Induces Memory Deficiencies in Newborns Rats</a></div><div class="wp-workCard_item"><span>Frontiers in Molecular Neuroscience</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Air pollution is fully acknowledged to represent a major public health issue. Toxic environmental...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Air pollution is fully acknowledged to represent a major public health issue. Toxic environmental substances, such as ozone, interfere with prenatal development. Animals exposed to ozone (O 3) in utero develop biochemical and morphological alterations. This gas has been proven to decrease cognitive capacity in different species. In the present study, we assessed the possible alterations in memory and spatial learning in the offspring of female rats who were exposed to 1.0 ppm of O 3 embryonic development. Two instruments were used to evaluate possible alterations: the T-maze and a Skinner box. MAPK, ERK, pERK , and NR2B proteins, which are widely regarded as responsible for the learning process in the hippocampus and cortex, were also assessed by immunohistochemistry. We found that male rats exposed to O 3 in utero displayed a significant delay to reach the correct response using the spatial learning test as compared to the control group. The female rats exposed to O 3 showed a significant delay to reach the correct response as compared to the female control group in the Skinner box. We also found that while the male rats showed decrease in significant differences in the expression of NR2B, ERK and increase in MAPK. Females only showed increase in MAPK, pERK and decrease in ERK, when compared to their respective control group. It is possible that the deficits are associated to hormonal expression, inflammation and oxidative stress alterations. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103890052"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103890052/Sleep_deprivation_and_sleep_recovery_modifies_connexin36_and_connexin43_protein_levels_in_rat_brain"><img alt="Research paper thumbnail of Sleep deprivation and sleep recovery modifies connexin36 and connexin43 protein levels in rat brain" class="work-thumbnail" src="https://attachments.academia-assets.com/103770246/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103890052/Sleep_deprivation_and_sleep_recovery_modifies_connexin36_and_connexin43_protein_levels_in_rat_brain">Sleep deprivation and sleep recovery modifies connexin36 and connexin43 protein levels in rat brain</a></div><div class="wp-workCard_item"><span>NeuroReport</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Gap junctional communication is mainly mediated by connexin36 and connexin43 in neurons and astro...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Gap junctional communication is mainly mediated by connexin36 and connexin43 in neurons and astrocytes, respectively. It has been suggested that connexin36 allows electrical coupling between neurons whereas connexin43 participates in several process including release of ATP. It was recently reported that blockage of gap junctional communication mediated by connexin36 can disrupt the sleep architecture of the rat. However, there is no experimental approach about effects of sleep deprivation on connexins expression. Therefore, we examined in adult male Wistar rats whether protein levels of connexin36 and connexin43 change in pons, hypothalamus, and frontal cortex after 24 h of total sleep deprivation and 4 h of sleep recovery. Western blot revealed that total sleep deprivation significantly decreases the levels of connexin36 in the hypothalamus and this decrease maintains after sleep recovery. Meanwhile, connexin43 is not altered by total sleep deprivation but interestingly the sleep recovery period induces an increase of this connexin. These results suggest that electrical coupling between hypothalamic neurons could be altered by sleep deprivation and that sleep recovery drives changes in connexin43 expression probably as a mechanism related to ATP release and energy regulation during sleep. NeuroReport</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cf33236626afa0560819fe1846aad38d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103770246,"asset_id":103890052,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103770246/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103890052"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103890052"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103890052; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=103890052]").text(description); $(".js-view-count[data-work-id=103890052]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 103890052; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='103890052']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cf33236626afa0560819fe1846aad38d" } } $('.js-work-strip[data-work-id=103890052]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":103890052,"title":"Sleep deprivation and sleep recovery modifies connexin36 and connexin43 protein levels in rat brain","internal_url":"https://www.academia.edu/103890052/Sleep_deprivation_and_sleep_recovery_modifies_connexin36_and_connexin43_protein_levels_in_rat_brain","owner_id":32300159,"coauthors_can_edit":true,"owner":{"id":32300159,"first_name":"Carlos","middle_initials":null,"last_name":"Tres","page_name":"CarlosTres","domain_name":"unam","created_at":"2015-06-17T16:57:13.353-07:00","display_name":"Carlos Tres","url":"https://unam.academia.edu/CarlosTres"},"attachments":[{"id":103770246,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/103770246/thumbnails/1.jpg","file_name":"wnr.0b013e32834e8fcb20230626-1-n2t1b9.pdf","download_url":"https://www.academia.edu/attachments/103770246/download_file","bulk_download_file_name":"Sleep_deprivation_and_sleep_recovery_mod.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/103770246/wnr.0b013e32834e8fcb20230626-1-n2t1b9-libre.pdf?1687807762=\u0026response-content-disposition=attachment%3B+filename%3DSleep_deprivation_and_sleep_recovery_mod.pdf\u0026Expires=1740305779\u0026Signature=RGTZVvf5ILmoeUaG5YQOS4TFuHmtfPVTCkUZ0vrnIjVQnk4FYmrcJGyD0JOtkkuvMHUTNRkAnlCyZMmT3qFUheawgnzlSXF~KcqqCH19Kiw6S5PRNrFDnhvmhChUKWDJfzWFUqMUvOFnLohxyDNztjlkXYkyMVLTbIoxLE8ZD9~j9AQYan1lfO-Y8CJYA1guTnyXnrWtPyvauwfH~1itF2tV8MRGEh4OKu6GQh2koQcwFIaqTF1PP48bw4wh3Sz03dqYMqxa383hIJ1GS6I3YDSE4ICAhKx27Z4lsV2Qa-gPS14gL2btN4XphNz021D5~ZuJDbsaZbrArYZRXNI-Eg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103890051"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103890051/Stimulation_of_the_superior_cerebellar_peduncle_during_the_development_of_amygdaloid_kindling_in_rats"><img alt="Research paper thumbnail of Stimulation of the superior cerebellar peduncle during the development of amygdaloid kindling in rats" class="work-thumbnail" src="https://attachments.academia-assets.com/103770344/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103890051/Stimulation_of_the_superior_cerebellar_peduncle_during_the_development_of_amygdaloid_kindling_in_rats">Stimulation of the superior cerebellar peduncle during the development of amygdaloid kindling in rats</a></div><div class="wp-workCard_item"><span>Brain Research</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cerebellar manipulations have been used successfully in some intractable epileptic patients, howe...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cerebellar manipulations have been used successfully in some intractable epileptic patients, however, their intrinsic mechanisms are not fully understood. To further clarify the cerebellar participation in epilepsy, we stimulated 10 rats with 100 Hz, 20 AA at the superior cerebellar peduncle (SCP) during amygdaloid kindling. Results were compared to 10 rats with an electrode placed at the SCP without stimulation and 10 rats without electrodes at the SCP used as control. We found that SCP stimulation increased the theta and alpha rhythms at the contralateral motor cortex. Such a stimulation produced hypertonicity of the forelimbs and tremor of the head. In this condition, we found that each of the behavioral stages during amygdaloid kindling in the SCP stimulated rats was reached earlier, while the amygdaloid electrographic afterdischarges (ADs) were longer during the first and shorter in the final trials as compared to controls. Moreover, amygdaloid ADs recorded exclusively during the behavioral stage-5 were significantly shorter than those recorded in the control conditions. We suggest that SCP stimulation could change the customary electrographic and convulsive expression of amygdala kindling in such a manner as to initially facilitate the limbic seizures and impede the secondary generalized seizures.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="03873e906ef5dc0cafa658e7078d5600" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103770344,"asset_id":103890051,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103770344/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103890051"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103890051"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103890051; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "03873e906ef5dc0cafa658e7078d5600" } } $('.js-work-strip[data-work-id=103890051]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":103890051,"title":"Stimulation of the superior cerebellar peduncle during the development of amygdaloid kindling in rats","internal_url":"https://www.academia.edu/103890051/Stimulation_of_the_superior_cerebellar_peduncle_during_the_development_of_amygdaloid_kindling_in_rats","owner_id":32300159,"coauthors_can_edit":true,"owner":{"id":32300159,"first_name":"Carlos","middle_initials":null,"last_name":"Tres","page_name":"CarlosTres","domain_name":"unam","created_at":"2015-06-17T16:57:13.353-07:00","display_name":"Carlos Tres","url":"https://unam.academia.edu/CarlosTres"},"attachments":[{"id":103770344,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/103770344/thumbnails/1.jpg","file_name":"2004A_2.pdf","download_url":"https://www.academia.edu/attachments/103770344/download_file","bulk_download_file_name":"Stimulation_of_the_superior_cerebellar_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/103770344/2004A_2-libre.pdf?1687807757=\u0026response-content-disposition=attachment%3B+filename%3DStimulation_of_the_superior_cerebellar_p.pdf\u0026Expires=1740305779\u0026Signature=c2rdiHjX0GPbeC-~I9bOx~tVbhRxjbKBdb4cQokgKpzXe7J4NQ1Ff0ea02UWeRv8QMyPkvU2wjrSy~p9JF8KhjWLhh8lRCHt7bYca0kZd0iZyXEpT~8QwjyP7W9YefiPJH3H1-4YcR2VgOn8QJnyf2p9JftLgAB6pZ3aWqDpiaeYjR-S8gy923Sve2rXlfxgha3RKJBc2c57uvqvZ4KGgUg0R0GC58SoFL1sQGFncqafMYU02X3UKXeIM32uZB3Z0EG4LbS5NUIeCGiRLjYV23igt1uEbYIHFbOgNzny8jndsgoxIjvVwIgNwZkNvGC0c3OSfNNeHnjNCukACvm-9A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103889877"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/103889877/Radiation_Induced_Neuroinflammation_and_Radiation_Somnolence_Syndrome"><img alt="Research paper thumbnail of Radiation-Induced Neuroinflammation and Radiation Somnolence Syndrome" class="work-thumbnail" src="https://attachments.academia-assets.com/103770038/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/103889877/Radiation_Induced_Neuroinflammation_and_Radiation_Somnolence_Syndrome">Radiation-Induced Neuroinflammation and Radiation Somnolence Syndrome</a></div><div class="wp-workCard_item"><span>CNS &amp; Neurological Disorders - Drug Targets</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="324be2c8c20d21f56fd499b291d793f8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103770038,"asset_id":103889877,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103770038/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103889877"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103889877"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103889877; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="99230498"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/99230498/_Major_neurotransmitters_involved_in_the_regulation_of_sleep_wake_cycle_"><img alt="Research paper thumbnail of [Major neurotransmitters involved in the regulation of sleep-wake cycle]" class="work-thumbnail" src="https://attachments.academia-assets.com/100374495/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/99230498/_Major_neurotransmitters_involved_in_the_regulation_of_sleep_wake_cycle_">[Major neurotransmitters involved in the regulation of sleep-wake cycle]</a></div><div class="wp-workCard_item"><span>Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Neuronal activity in the central nervous system undergoes a variety of electrophysiological chang...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Neuronal activity in the central nervous system undergoes a variety of electrophysiological changes along the sleep-wake cycle. These changes are modulated by a complex interaction between different neurochemical systems located throughout the brain. Within brainstem and hypothalamus there are a number of neuronal populations that promote wakefulness through the action of different neurotransmitters like noradrenaline, serotonin, histamine and orexin. These systems act together in the generation and maintenance of wakefulness, however although each one contributes in a unique way no neurotransmitter seems to be absolutely necessary because wakefulness is not completely inhibited in the absence of any of them. On the other hand, neurons located in the hypothalamus and brainstem are involved in initiating and maintaining sleep. These neurons contain neurotransmitters such as acetylcholine and GABA and have projections to nuclei involved in wakefulness regulation. Recently, models have...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7e3b35c9e51d140c26708c74b877c999" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":100374495,"asset_id":99230498,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/100374495/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="99230498"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="99230498"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 99230498; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90279126"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/90279126/Inverse_volume_pore_pressure_projection_technique_for_the_coupling_of_reservoir_flow_and_geomechanics_simulators"><img alt="Research paper thumbnail of Inverse-volume pore pressure projection technique for the coupling of reservoir flow and geomechanics simulators" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/90279126/Inverse_volume_pore_pressure_projection_technique_for_the_coupling_of_reservoir_flow_and_geomechanics_simulators">Inverse-volume pore pressure projection technique for the coupling of reservoir flow and geomechanics simulators</a></div><div class="wp-workCard_item"><span>Energy Geotechnics</span><span>, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90279126"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90279126"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90279126; 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</script> <div class="js-work-strip profile--work_container" data-work-id="90279124"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90279124/Participation_of_the_dentate_rubral_pathway_in_the_kindling_model_of_epilepsy"><img alt="Research paper thumbnail of Participation of the dentate-rubral pathway in the kindling model of epilepsy" class="work-thumbnail" src="https://attachments.academia-assets.com/93885851/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90279124/Participation_of_the_dentate_rubral_pathway_in_the_kindling_model_of_epilepsy">Participation of the dentate-rubral pathway in the kindling model of epilepsy</a></div><div class="wp-workCard_item"><span>Journal of Neuroscience Research</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Lesions of the cerebellar dentate nucleus (DN) reduce the after-discharge duration induced by rep...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Lesions of the cerebellar dentate nucleus (DN) reduce the after-discharge duration induced by repetitive kindling stimulation and decrease seizures to a lower rank according to Racine's scale. The DN sends cholinergic and glutamatergic fibers to the red nucleus (RN), which is composed of glutamatergic and GABAergic cells. To test the participation of these neurotransmitters in seizures, we compared the levels of glutamate and gamma-aminobutyric acid (GABA) at the RN in a control condition, a kindled stage, and a kindled stage followed by DN lesions. We found that the kindled stage was associated with significant reductions in glutamate and GABA in the RN and that the lesions of the DN in kindled rats reversed the severity of seizures and restored the GABA levels. GAD 65 , a GABA-synthesizing enzyme, was increased in kindled rats and decreased after DN lesions. GAD 65 commonly appears localized at nerve terminals and synapses, and it is only activated when GABA neurotransmission occurs. Thus, it is possible that the increased expression of GAD 65 found in kindled rats could be due to an exacerbated demand for GABA due to kindled seizures. It is known that GABA maintains the inhibitory tone that counterbalances neuronal excitation. The decreased expression of GAD 65 found after the DN lesions indicated that the GABA-synthesizing enzyme was no longer required once it eliminated the excitatory glutamate input to the RN. We thus conclude that DN lesions and their consequent biochemical changes are capable of decreasing the generalized seizures induced by kindling stimulation. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90279122"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/90279122/Modelos_Experimentales_De_Epilepsia"><img alt="Research paper thumbnail of Modelos Experimentales De Epilepsia" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/90279122/Modelos_Experimentales_De_Epilepsia">Modelos Experimentales De Epilepsia</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90279122"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90279122"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90279122; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90279122]").text(description); $(".js-view-count[data-work-id=90279122]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90279122; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90279122']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90279122]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90279122,"title":"Modelos Experimentales De Epilepsia","internal_url":"https://www.academia.edu/90279122/Modelos_Experimentales_De_Epilepsia","owner_id":32300159,"coauthors_can_edit":true,"owner":{"id":32300159,"first_name":"Carlos","middle_initials":null,"last_name":"Tres","page_name":"CarlosTres","domain_name":"unam","created_at":"2015-06-17T16:57:13.353-07:00","display_name":"Carlos Tres","url":"https://unam.academia.edu/CarlosTres"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90279119"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/90279119/Exposure_to_ozone_induces_a_systemic_inflammatory_response_possible_source_of_the_neurological_alterations_induced_by_this_gas"><img alt="Research paper thumbnail of Exposure to ozone induces a systemic inflammatory response: possible source of the neurological alterations induced by this gas" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/90279119/Exposure_to_ozone_induces_a_systemic_inflammatory_response_possible_source_of_the_neurological_alterations_induced_by_this_gas">Exposure to ozone induces a systemic inflammatory response: possible source of the neurological alterations induced by this gas</a></div><div class="wp-workCard_item"><span>Inhalation Toxicology</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The World Health Organization identified urban outdoor air pollution as the eighth highest mortal...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The World Health Organization identified urban outdoor air pollution as the eighth highest mortality risk factor in high-income countries. Exposure to ambient pollutants such as ozone (O3) increases the number of hospital admissions. O3 is a highly reactive gas that reacts with cells lining the airways, producing the formation of reactive oxygen species and inflammation. Beyond the respiratory system, O3 exposure also produces fatigue, lethargy, headaches, and significant decrease in rapid-eye-movement sleep related to an increase in slow-wave sleep. Interestingly, these sleep changes can be significantly mitigated by treatment with indomethacin, which suggests that an inflammatory mechanism may be responsible for these neurological symptoms. To characterize the inflammatory mechanisms by which O3 affects tissues outside the pulmonary system, we evaluated inflammatory factors in both lung and brain. Rats exposed to 1 part per million O3 for 1, 3 or 6 h, as well as rats exposed daily for 1 or 3 h over five consecutive days, showed increases in TNF-α and IL-6 levels within the lungs as well as increases in TNF-α, IL-6, NF-κB p50 and GFAP levels in the cerebral cortex. These results support the hypothesis that the neuroinflammatory response may be responsible for the central nervous system effects of O3 exposure.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90279119"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90279119"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90279119; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90279119]").text(description); $(".js-view-count[data-work-id=90279119]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90279119; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90279119']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="90278344"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/90278344/The_effects_of_ozone_exposure_and_associated_injury_mechanisms_on_the_central_nervous_system"><img alt="Research paper thumbnail of The effects of ozone exposure and associated injury mechanisms on the central nervous system" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/90278344/The_effects_of_ozone_exposure_and_associated_injury_mechanisms_on_the_central_nervous_system">The effects of ozone exposure and associated injury mechanisms on the central nervous system</a></div><div class="wp-workCard_item"><span>Reviews in the Neurosciences</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ozone (O3) is a component of photochemical smog, which is a major air pollutant and demonstrates ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ozone (O3) is a component of photochemical smog, which is a major air pollutant and demonstrates properties that are harmful to health because of the toxic properties that are inherent to its powerful oxidizing capabilities. Environmental O3 exposure is associated with many symptoms related to respiratory disorders, which include loss of lung function, exacerbation of asthma, airway damage, and lung inflammation. The effects of O3 are not restricted to the respiratory system or function - adverse effects within the central nervous system (CNS) such as decreased cognitive response, decrease in motor activity, headaches, disturbances in the sleep-wake cycle, neuronal dysfunctions, cell degeneration, and neurochemical alterations have also been described; furthermore, it has also been proposed that O3 could have epigenetic effects. O3 exposure induces the reactive chemical species in the lungs, but the short half-life of these chemical species has led some authors to attribute the injurious mechanisms observed within the lungs to inflammatory processes. However, the damage to the CNS induced by O3 exposure is not well understood. In this review, the basic mechanisms of inflammation and activation of the immune system by O3 exposure are described and the potential mechanisms of damage, which include neuroinflammation and oxidative stress, and the signs and symptoms of disturbances within the CNS caused by environmental O3 exposure are discussed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90278344"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90278344"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90278344; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90278344]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90278344,"title":"The effects of ozone exposure and associated injury mechanisms on the central nervous system","internal_url":"https://www.academia.edu/90278344/The_effects_of_ozone_exposure_and_associated_injury_mechanisms_on_the_central_nervous_system","owner_id":32300159,"coauthors_can_edit":true,"owner":{"id":32300159,"first_name":"Carlos","middle_initials":null,"last_name":"Tres","page_name":"CarlosTres","domain_name":"unam","created_at":"2015-06-17T16:57:13.353-07:00","display_name":"Carlos Tres","url":"https://unam.academia.edu/CarlosTres"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90278343"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90278343/Whole_brain_irradiation_increases_NREM_sleep_and_hypothalamic_expression_of_IL_1%CE%B2_in_rats"><img alt="Research paper thumbnail of Whole-brain irradiation increases NREM sleep and hypothalamic expression of IL-1β in rats" class="work-thumbnail" src="https://attachments.academia-assets.com/93885230/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90278343/Whole_brain_irradiation_increases_NREM_sleep_and_hypothalamic_expression_of_IL_1%CE%B2_in_rats">Whole-brain irradiation increases NREM sleep and hypothalamic expression of IL-1β in rats</a></div><div class="wp-workCard_item"><span>International Journal of Radiation Biology</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2d69b6512f332b6723467cbfbbd41590" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93885230,"asset_id":90278343,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93885230/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90278343"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90278343"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90278343; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90278343]").text(description); $(".js-view-count[data-work-id=90278343]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90278343; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90278343']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90278342"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90278342/Sleep_and_brain_monoamine_changes_produced_by_acute_and_chronic_acetaldehyde_administration_in_rats"><img alt="Research paper thumbnail of Sleep and brain monoamine changes produced by acute and chronic acetaldehyde administration in rats" class="work-thumbnail" src="https://attachments.academia-assets.com/93885244/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90278342/Sleep_and_brain_monoamine_changes_produced_by_acute_and_chronic_acetaldehyde_administration_in_rats">Sleep and brain monoamine changes produced by acute and chronic acetaldehyde administration in rats</a></div><div class="wp-workCard_item"><span>Behavioural Brain Research</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Acetaldehyde, the most toxic metabolite of ethanol, has been implicated in many toxic effects of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Acetaldehyde, the most toxic metabolite of ethanol, has been implicated in many toxic effects of ethanol. In the present study, we used rats to investigate the possible changes on the sleep-wake cycle and brain regional concentrations of noradrenaline and serotonin after intraperitoneal administration of several doses of acetaldehyde. Results showed that acetaldehyde significantly decreases the time spent in rapid eye movements sleep and wakefulness and increases the time spent in slow-wave sleep. The neurochemical analysis showed that acetaldehyde significantly increases the 5-hydroxyindolacetic acid content and 5-hydroxyindolacetic acid/serotonin ratio at the bulb and pons. These results suggest that acetaldehyde modifies the metabolism of serotonin which has been implicated in the onset and sustaining of the sleep episodes occurring along the sleep-wake cycle.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="518e7e7d9304238c2cb6460c668a8409" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93885244,"asset_id":90278342,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93885244/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90278342"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90278342"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90278342; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90278108"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90278108/Surgical_alternatives_for_the_control_of_epileptic_seizures"><img alt="Research paper thumbnail of Surgical alternatives for the control of epileptic seizures" class="work-thumbnail" src="https://attachments.academia-assets.com/93885048/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90278108/Surgical_alternatives_for_the_control_of_epileptic_seizures">Surgical alternatives for the control of epileptic seizures</a></div><div class="wp-workCard_item"><span>Neurology and Neurosurgery</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Patients with medically intractable epilepsy are candidates for surgical treatment. The main goal...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Patients with medically intractable epilepsy are candidates for surgical treatment. The main goals of treatment consist in the ablation of epileptogenic areas, surgical sectioning of the corpus callosum in order to avoid interhemispheric transmission of epileptic electrical activity and stimulation of brain areas capable of inducing inhibition of epileptic activity. Another alternative is the injury of structures such as the dentate nucleus of the cerebellum, which has shown beneficial effects in patients. However, most of these surgical treatments involve healthy brain areas and implicate excessive costs. In this review we discuss previous works that describe surgical techniques and their main post-surgical complications.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f34dd0c5764baab4d123f8ba841863ec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93885048,"asset_id":90278108,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93885048/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90278108"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90278108"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90278108; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=59518598]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":59518598,"title":"Metformin Plus Caloric Restriction Show Anti-epileptic Effects Mediated by mTOR Pathway Inhibition","internal_url":"https://www.academia.edu/59518598/Metformin_Plus_Caloric_Restriction_Show_Anti_epileptic_Effects_Mediated_by_mTOR_Pathway_Inhibition","owner_id":32300159,"coauthors_can_edit":true,"owner":{"id":32300159,"first_name":"Carlos","middle_initials":null,"last_name":"Tres","page_name":"CarlosTres","domain_name":"unam","created_at":"2015-06-17T16:57:13.353-07:00","display_name":"Carlos Tres","url":"https://unam.academia.edu/CarlosTres"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="59518587"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/59518587/Systemic_inflammation_and_neuronal_dysfunction_produced_by_ozone_exposure"><img alt="Research paper thumbnail of Systemic inflammation and neuronal dysfunction produced by ozone exposure" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/59518587/Systemic_inflammation_and_neuronal_dysfunction_produced_by_ozone_exposure">Systemic inflammation and neuronal dysfunction produced by ozone exposure</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="59518587"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="59518587"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 59518587; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=59518587]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":59518587,"title":"Systemic inflammation and neuronal dysfunction produced by ozone exposure","internal_url":"https://www.academia.edu/59518587/Systemic_inflammation_and_neuronal_dysfunction_produced_by_ozone_exposure","owner_id":32300159,"coauthors_can_edit":true,"owner":{"id":32300159,"first_name":"Carlos","middle_initials":null,"last_name":"Tres","page_name":"CarlosTres","domain_name":"unam","created_at":"2015-06-17T16:57:13.353-07:00","display_name":"Carlos Tres","url":"https://unam.academia.edu/CarlosTres"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="59518581"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/59518581/Caloric_restriction_protects_against_electrical_kindling_of_the_amygdala_by_inhibiting_the_mTOR_signaling_pathway"><img alt="Research paper thumbnail of Caloric restriction protects against electrical kindling of the amygdala by inhibiting the mTOR signaling pathway" class="work-thumbnail" src="https://attachments.academia-assets.com/73400036/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/59518581/Caloric_restriction_protects_against_electrical_kindling_of_the_amygdala_by_inhibiting_the_mTOR_signaling_pathway">Caloric restriction protects against electrical kindling of the amygdala by inhibiting the mTOR signaling pathway</a></div><div class="wp-workCard_item"><span>Frontiers in Cellular Neuroscience</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">KG (2015) Caloric restriction protects against electrical kindling of the amygdala by inhibiting ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">KG (2015) Caloric restriction protects against electrical kindling of the amygdala by inhibiting the mTOR signaling pathway.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5101a439dd860d8392fc853f6163c15e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":73400036,"asset_id":59518581,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/73400036/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="59518581"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="59518581"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 59518581; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="59518573"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/59518573/Quinine_a_selective_gap_junction_blocker_decreases_REM_sleep_in_rats"><img alt="Research paper thumbnail of Quinine, a selective gap junction blocker, decreases REM sleep in rats" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/59518573/Quinine_a_selective_gap_junction_blocker_decreases_REM_sleep_in_rats">Quinine, a selective gap junction blocker, decreases REM sleep in rats</a></div><div class="wp-workCard_item"><span>Pharmacology Biochemistry and Behavior</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Electrical synapses are formed by gap junctions that allow the direct communication between neuro...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Electrical synapses are formed by gap junctions that allow the direct communication between neurons, the intercellular transference of ions and small molecules as well as the electrical coupling of the cells. Electrical coupling in neurons is mediated by the gap junction protein connexin36. There are reports about the presence of electrical coupling in the sublaterodorsal nucleus and pedunculopontine nucleus, which have been implicated in the modulation of the rapid eye movement sleep. In the present study, rats were used to examine the possible changes on the sleep-wake states after intracerebroventricular administration of several doses of quinine, a selective blocker of gap junctions formed by connexin36. The results showed that quinine significantly increased the time spent in wakefulness and decreased the time spent in slow wave sleep along the 24h of polygraphic recording. The three doses used of quinine caused a significant decrease of rapid eye movement sleep along the light phase; however, only one dose extended such effect until the darkness phase. The changes on sleep-wake states of the rat after the blockage of gap junctions formed by connexin36 suggest that electrical synapses could contribute to the regulation of sleep-wake states in concert with the well-known chemical neurotransmission.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="59518573"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="59518573"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 59518573; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=59518573]").text(description); $(".js-view-count[data-work-id=59518573]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 59518573; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='59518573']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=59518573]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":59518573,"title":"Quinine, a selective gap junction blocker, decreases REM sleep in rats","internal_url":"https://www.academia.edu/59518573/Quinine_a_selective_gap_junction_blocker_decreases_REM_sleep_in_rats","owner_id":32300159,"coauthors_can_edit":true,"owner":{"id":32300159,"first_name":"Carlos","middle_initials":null,"last_name":"Tres","page_name":"CarlosTres","domain_name":"unam","created_at":"2015-06-17T16:57:13.353-07:00","display_name":"Carlos Tres","url":"https://unam.academia.edu/CarlosTres"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="59518566"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/59518566/PVN_electrical_stimulation_prolongs_withdrawal_latencies_and_releases_oxytocin_in_cerebrospinal_fluid_plasma_and_spinal_cord_tissue_in_intact_and_neuropathic_rats"><img alt="Research paper thumbnail of PVN electrical stimulation prolongs withdrawal latencies and releases oxytocin in cerebrospinal fluid, plasma, and spinal cord tissue in intact and neuropathic rats" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/59518566/PVN_electrical_stimulation_prolongs_withdrawal_latencies_and_releases_oxytocin_in_cerebrospinal_fluid_plasma_and_spinal_cord_tissue_in_intact_and_neuropathic_rats">PVN electrical stimulation prolongs withdrawal latencies and releases oxytocin in cerebrospinal fluid, plasma, and spinal cord tissue in intact and neuropathic rats</a></div><div class="wp-workCard_item"><span>PAIN</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We are studying an endogenous, oxytocinergic analgesia system to obtain more information about no...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We are studying an endogenous, oxytocinergic analgesia system to obtain more information about normal and pathological pain processes. In the recent years, this oxytocinergic system has been shown to be involved in normal and pathological pain suppression. The paraventricular nucleus (PVN) of the hypothalamus is an important source of brain oxytocin (OT). A descending pathway reaching the dorsal horn in the spinal cord was postulated to mediate analgesic effects at the spinal cord level. However, the oxytocin concentration during pain conditions and during PVN electrical stimulation needs to be determined. We designed experiments to measure the OT concentration in cerebrospinal fluid (CSF), plasma, and OT protein in lumbar spinal cord tissue in control and neuropathic rats. Sciatic loose ligature was used as the experimental method to produce neuropathic pain. The main findings were (1) Chronic pain experiments in animals showed that the stimulation of the anterior part of the PVN increased OT concentration and produced analgesia states, as measured by von Frey, cold, and heat plantar tests. (2) Differential effects were produced by electrical stimulation of the anterior or posterior regions of the PVN; electrical stimulation of the anterior part of the PVN enhanced the OT concentration in CSF and plasma, and it also increased OT protein concentrations in the spinal cord tissue; in contrast, the stimulation of the posterior part of the PVN only increased OT concentrations in CSF. These results suggest the participation of an endogenous analgesia system mediated by OT.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="59518566"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="59518566"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 59518566; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=59518566]").text(description); 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=59518566]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":59518566,"title":"PVN electrical stimulation prolongs withdrawal latencies and releases oxytocin in cerebrospinal fluid, plasma, and spinal cord tissue in intact and neuropathic rats","internal_url":"https://www.academia.edu/59518566/PVN_electrical_stimulation_prolongs_withdrawal_latencies_and_releases_oxytocin_in_cerebrospinal_fluid_plasma_and_spinal_cord_tissue_in_intact_and_neuropathic_rats","owner_id":32300159,"coauthors_can_edit":true,"owner":{"id":32300159,"first_name":"Carlos","middle_initials":null,"last_name":"Tres","page_name":"CarlosTres","domain_name":"unam","created_at":"2015-06-17T16:57:13.353-07:00","display_name":"Carlos Tres","url":"https://unam.academia.edu/CarlosTres"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="59518558"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/59518558/Initial_experience_in_Brazil_with_the_Helex_septal_occluder_for_percutaneous_occlusion_of_atrial_septal_defects"><img alt="Research paper thumbnail of Initial experience in Brazil with the Helex septal occluder for percutaneous occlusion of atrial septal defects" class="work-thumbnail" src="https://attachments.academia-assets.com/73400041/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/59518558/Initial_experience_in_Brazil_with_the_Helex_septal_occluder_for_percutaneous_occlusion_of_atrial_septal_defects">Initial experience in Brazil with the Helex septal occluder for percutaneous occlusion of atrial septal defects</a></div><div class="wp-workCard_item"><span>Arquivos Brasileiros de Cardiologia</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the last 10-15 years, major advances in the percutaneous treatment of atrial septal defects wi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the last 10-15 years, major advances in the percutaneous treatment of atrial septal defects with the use of several occluding devices has occurred with progressive improvement in the results 1-14. Because this approach currently provides excellent occlusive results with minimum morbidity and mortality in short and medium follow-up with obvious advantages regarding the surgical approach 8-17 , it is considered the method of choice for the treatment of selected patients in several medical centers around the world. However, some devices have not been widely accepted by interventionists because they possess characteristics far from those considered ideal 1-7. The most commonly used, including in our group, are the Amplatzer Septal Occluder (AGA Medical Corporation, Golden Valley, MN) 10-16 the CardioSEAL septal occluder and the STARFlex (Nitinol Medical Technologies, Boston, MA) 8,9. Recently, a new device, the Helex septal occluder (W.L. Gore and Associates, Flagstaff, AZ) was introduced for clinical use after encouraging results from experimental studies 18. We report herein the initial experience at 2 Brazilian centers with the new Helex device. Methods The Helex septal occluder is composed of a single flexible nitinol wire frame tridimensionally helically shaped, with a 0.012-inch diameter, covered with a thin polytetrafluoroethylene membrane (PTFE better known as Gore-Tex) (fig.1). For implantation, the frame is sealed in a central mandrel and pulled inside a delivery catheter (9F) (fig 1). As the device is extruded from the catheter, it assumes a helicoidal configuration (therefore the name Helex). It is composed of 2 flexible disks with round borders that are positioned through the hole within the septum. The Helex septal occluder is available on the market in 5 diameters, 15 to 35mm, in 5mm increments. Three small metal loops also called "eyelets" are found in the center of the disks, one more distal (outside the disk on the left side), one between the 2 disks, and another proximal, (outside the disk on the right side). Within the proximal waist is a retrieval cord made of polytetrafluoroethylene 18,19. Objective-To evaluate the initial clinical experience with the Helex septal occluder for percutaneous closure of atrial septal defects. Methods-Ten patients underwent the procedure, 7 patients with ostium secundum atrial septal defects (ASD) with hemodynamic repercussions and 3 patients with pervious foramen ovale (PFO) and a history of stroke. Mean age was 33.8 years and mean weight was 55.4 kg. Mean diameter by transesophageal echocardiography and mean stretched ASD diameter were 11.33 ± 3.3mm, and 15.2 ± 3.8mm, respectively. The Qp/Qs ratio was 1.9 ± 0.3 in patients with ASD. Results-Eleven occluders were placed because a patient with 2 holes needed 2 devices. It was necessary to retrieve and replace 4 devices in 3 patients. We observed immediate residual shunt (< 2mm) in 4 patients with ASD, and in those with patent foramen ovale total occlusion of the defect occurred. No complications were noted, and all patients were discharged on the following day. After 1 month, 2 patients with ASD experienced trivial residual shunts (1mm). In 1 patient, we observed mild prolapse in the proximal disk in the right atrium, without consequences. Conclusion-The Helex septal occluder was safe and effective for occluding small to moderate atrial septal defects. Because the implantation technique is demanding, it requires specific training of the operator. Even so, small technical failures may occur in the beginning of the learning curve, but they do not involve patient safety.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fd1991cef8130ef1645b3de58ad0ce35" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":73400041,"asset_id":59518558,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/73400041/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="59518558"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="59518558"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 59518558; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3051561" id="papers"><div class="js-work-strip profile--work_container" data-work-id="122938147"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122938147/Prenatal_Ozone_Exposure_Induces_Memory_Deficiencies_in_Newborns_Rats"><img alt="Research paper thumbnail of Prenatal Ozone Exposure Induces Memory Deficiencies in Newborns Rats" class="work-thumbnail" src="https://attachments.academia-assets.com/117493379/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122938147/Prenatal_Ozone_Exposure_Induces_Memory_Deficiencies_in_Newborns_Rats">Prenatal Ozone Exposure Induces Memory Deficiencies in Newborns Rats</a></div><div class="wp-workCard_item"><span>Frontiers in Molecular Neuroscience</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Air pollution is fully acknowledged to represent a major public health issue. Toxic environmental...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Air pollution is fully acknowledged to represent a major public health issue. Toxic environmental substances, such as ozone, interfere with prenatal development. Animals exposed to ozone (O 3) in utero develop biochemical and morphological alterations. This gas has been proven to decrease cognitive capacity in different species. In the present study, we assessed the possible alterations in memory and spatial learning in the offspring of female rats who were exposed to 1.0 ppm of O 3 embryonic development. Two instruments were used to evaluate possible alterations: the T-maze and a Skinner box. MAPK, ERK, pERK , and NR2B proteins, which are widely regarded as responsible for the learning process in the hippocampus and cortex, were also assessed by immunohistochemistry. We found that male rats exposed to O 3 in utero displayed a significant delay to reach the correct response using the spatial learning test as compared to the control group. The female rats exposed to O 3 showed a significant delay to reach the correct response as compared to the female control group in the Skinner box. We also found that while the male rats showed decrease in significant differences in the expression of NR2B, ERK and increase in MAPK. Females only showed increase in MAPK, pERK and decrease in ERK, when compared to their respective control group. It is possible that the deficits are associated to hormonal expression, inflammation and oxidative stress alterations. In summary, these results suggest that exposure to O 3 can interfere with prenatal development, resulting in learning and memory deficiencies in rats.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="95c62cecc78a3a67a1e53fa971d3fd41" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117493379,"asset_id":122938147,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117493379/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122938147"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122938147"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122938147; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103890052"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103890052/Sleep_deprivation_and_sleep_recovery_modifies_connexin36_and_connexin43_protein_levels_in_rat_brain"><img alt="Research paper thumbnail of Sleep deprivation and sleep recovery modifies connexin36 and connexin43 protein levels in rat brain" class="work-thumbnail" src="https://attachments.academia-assets.com/103770246/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103890052/Sleep_deprivation_and_sleep_recovery_modifies_connexin36_and_connexin43_protein_levels_in_rat_brain">Sleep deprivation and sleep recovery modifies connexin36 and connexin43 protein levels in rat brain</a></div><div class="wp-workCard_item"><span>NeuroReport</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Gap junctional communication is mainly mediated by connexin36 and connexin43 in neurons and astro...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Gap junctional communication is mainly mediated by connexin36 and connexin43 in neurons and astrocytes, respectively. It has been suggested that connexin36 allows electrical coupling between neurons whereas connexin43 participates in several process including release of ATP. It was recently reported that blockage of gap junctional communication mediated by connexin36 can disrupt the sleep architecture of the rat. However, there is no experimental approach about effects of sleep deprivation on connexins expression. Therefore, we examined in adult male Wistar rats whether protein levels of connexin36 and connexin43 change in pons, hypothalamus, and frontal cortex after 24 h of total sleep deprivation and 4 h of sleep recovery. Western blot revealed that total sleep deprivation significantly decreases the levels of connexin36 in the hypothalamus and this decrease maintains after sleep recovery. Meanwhile, connexin43 is not altered by total sleep deprivation but interestingly the sleep recovery period induces an increase of this connexin. These results suggest that electrical coupling between hypothalamic neurons could be altered by sleep deprivation and that sleep recovery drives changes in connexin43 expression probably as a mechanism related to ATP release and energy regulation during sleep. NeuroReport</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cf33236626afa0560819fe1846aad38d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103770246,"asset_id":103890052,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103770246/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103890052"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103890052"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103890052; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=103890052]").text(description); $(".js-view-count[data-work-id=103890052]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 103890052; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='103890052']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cf33236626afa0560819fe1846aad38d" } } $('.js-work-strip[data-work-id=103890052]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":103890052,"title":"Sleep deprivation and sleep recovery modifies connexin36 and connexin43 protein levels in rat brain","internal_url":"https://www.academia.edu/103890052/Sleep_deprivation_and_sleep_recovery_modifies_connexin36_and_connexin43_protein_levels_in_rat_brain","owner_id":32300159,"coauthors_can_edit":true,"owner":{"id":32300159,"first_name":"Carlos","middle_initials":null,"last_name":"Tres","page_name":"CarlosTres","domain_name":"unam","created_at":"2015-06-17T16:57:13.353-07:00","display_name":"Carlos Tres","url":"https://unam.academia.edu/CarlosTres"},"attachments":[{"id":103770246,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/103770246/thumbnails/1.jpg","file_name":"wnr.0b013e32834e8fcb20230626-1-n2t1b9.pdf","download_url":"https://www.academia.edu/attachments/103770246/download_file","bulk_download_file_name":"Sleep_deprivation_and_sleep_recovery_mod.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/103770246/wnr.0b013e32834e8fcb20230626-1-n2t1b9-libre.pdf?1687807762=\u0026response-content-disposition=attachment%3B+filename%3DSleep_deprivation_and_sleep_recovery_mod.pdf\u0026Expires=1740305779\u0026Signature=RGTZVvf5ILmoeUaG5YQOS4TFuHmtfPVTCkUZ0vrnIjVQnk4FYmrcJGyD0JOtkkuvMHUTNRkAnlCyZMmT3qFUheawgnzlSXF~KcqqCH19Kiw6S5PRNrFDnhvmhChUKWDJfzWFUqMUvOFnLohxyDNztjlkXYkyMVLTbIoxLE8ZD9~j9AQYan1lfO-Y8CJYA1guTnyXnrWtPyvauwfH~1itF2tV8MRGEh4OKu6GQh2koQcwFIaqTF1PP48bw4wh3Sz03dqYMqxa383hIJ1GS6I3YDSE4ICAhKx27Z4lsV2Qa-gPS14gL2btN4XphNz021D5~ZuJDbsaZbrArYZRXNI-Eg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103890051"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103890051/Stimulation_of_the_superior_cerebellar_peduncle_during_the_development_of_amygdaloid_kindling_in_rats"><img alt="Research paper thumbnail of Stimulation of the superior cerebellar peduncle during the development of amygdaloid kindling in rats" class="work-thumbnail" src="https://attachments.academia-assets.com/103770344/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103890051/Stimulation_of_the_superior_cerebellar_peduncle_during_the_development_of_amygdaloid_kindling_in_rats">Stimulation of the superior cerebellar peduncle during the development of amygdaloid kindling in rats</a></div><div class="wp-workCard_item"><span>Brain Research</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cerebellar manipulations have been used successfully in some intractable epileptic patients, howe...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cerebellar manipulations have been used successfully in some intractable epileptic patients, however, their intrinsic mechanisms are not fully understood. To further clarify the cerebellar participation in epilepsy, we stimulated 10 rats with 100 Hz, 20 AA at the superior cerebellar peduncle (SCP) during amygdaloid kindling. Results were compared to 10 rats with an electrode placed at the SCP without stimulation and 10 rats without electrodes at the SCP used as control. We found that SCP stimulation increased the theta and alpha rhythms at the contralateral motor cortex. Such a stimulation produced hypertonicity of the forelimbs and tremor of the head. In this condition, we found that each of the behavioral stages during amygdaloid kindling in the SCP stimulated rats was reached earlier, while the amygdaloid electrographic afterdischarges (ADs) were longer during the first and shorter in the final trials as compared to controls. Moreover, amygdaloid ADs recorded exclusively during the behavioral stage-5 were significantly shorter than those recorded in the control conditions. We suggest that SCP stimulation could change the customary electrographic and convulsive expression of amygdala kindling in such a manner as to initially facilitate the limbic seizures and impede the secondary generalized seizures.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="03873e906ef5dc0cafa658e7078d5600" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103770344,"asset_id":103890051,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103770344/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103890051"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103890051"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103890051; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103889877"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/103889877/Radiation_Induced_Neuroinflammation_and_Radiation_Somnolence_Syndrome"><img alt="Research paper thumbnail of Radiation-Induced Neuroinflammation and Radiation Somnolence Syndrome" class="work-thumbnail" src="https://attachments.academia-assets.com/103770038/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/103889877/Radiation_Induced_Neuroinflammation_and_Radiation_Somnolence_Syndrome">Radiation-Induced Neuroinflammation and Radiation Somnolence Syndrome</a></div><div class="wp-workCard_item"><span>CNS &amp; Neurological Disorders - Drug Targets</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="324be2c8c20d21f56fd499b291d793f8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103770038,"asset_id":103889877,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103770038/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103889877"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103889877"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103889877; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="99230498"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/99230498/_Major_neurotransmitters_involved_in_the_regulation_of_sleep_wake_cycle_"><img alt="Research paper thumbnail of [Major neurotransmitters involved in the regulation of sleep-wake cycle]" class="work-thumbnail" src="https://attachments.academia-assets.com/100374495/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/99230498/_Major_neurotransmitters_involved_in_the_regulation_of_sleep_wake_cycle_">[Major neurotransmitters involved in the regulation of sleep-wake cycle]</a></div><div class="wp-workCard_item"><span>Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Neuronal activity in the central nervous system undergoes a variety of electrophysiological chang...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Neuronal activity in the central nervous system undergoes a variety of electrophysiological changes along the sleep-wake cycle. These changes are modulated by a complex interaction between different neurochemical systems located throughout the brain. Within brainstem and hypothalamus there are a number of neuronal populations that promote wakefulness through the action of different neurotransmitters like noradrenaline, serotonin, histamine and orexin. These systems act together in the generation and maintenance of wakefulness, however although each one contributes in a unique way no neurotransmitter seems to be absolutely necessary because wakefulness is not completely inhibited in the absence of any of them. On the other hand, neurons located in the hypothalamus and brainstem are involved in initiating and maintaining sleep. These neurons contain neurotransmitters such as acetylcholine and GABA and have projections to nuclei involved in wakefulness regulation. Recently, models have...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7e3b35c9e51d140c26708c74b877c999" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":100374495,"asset_id":99230498,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/100374495/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="99230498"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="99230498"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 99230498; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90279126"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/90279126/Inverse_volume_pore_pressure_projection_technique_for_the_coupling_of_reservoir_flow_and_geomechanics_simulators"><img alt="Research paper thumbnail of Inverse-volume pore pressure projection technique for the coupling of reservoir flow and geomechanics simulators" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/90279126/Inverse_volume_pore_pressure_projection_technique_for_the_coupling_of_reservoir_flow_and_geomechanics_simulators">Inverse-volume pore pressure projection technique for the coupling of reservoir flow and geomechanics simulators</a></div><div class="wp-workCard_item"><span>Energy Geotechnics</span><span>, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90279126"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90279126"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90279126; 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</script> <div class="js-work-strip profile--work_container" data-work-id="90279124"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90279124/Participation_of_the_dentate_rubral_pathway_in_the_kindling_model_of_epilepsy"><img alt="Research paper thumbnail of Participation of the dentate-rubral pathway in the kindling model of epilepsy" class="work-thumbnail" src="https://attachments.academia-assets.com/93885851/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90279124/Participation_of_the_dentate_rubral_pathway_in_the_kindling_model_of_epilepsy">Participation of the dentate-rubral pathway in the kindling model of epilepsy</a></div><div class="wp-workCard_item"><span>Journal of Neuroscience Research</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Lesions of the cerebellar dentate nucleus (DN) reduce the after-discharge duration induced by rep...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Lesions of the cerebellar dentate nucleus (DN) reduce the after-discharge duration induced by repetitive kindling stimulation and decrease seizures to a lower rank according to Racine's scale. The DN sends cholinergic and glutamatergic fibers to the red nucleus (RN), which is composed of glutamatergic and GABAergic cells. To test the participation of these neurotransmitters in seizures, we compared the levels of glutamate and gamma-aminobutyric acid (GABA) at the RN in a control condition, a kindled stage, and a kindled stage followed by DN lesions. We found that the kindled stage was associated with significant reductions in glutamate and GABA in the RN and that the lesions of the DN in kindled rats reversed the severity of seizures and restored the GABA levels. GAD 65 , a GABA-synthesizing enzyme, was increased in kindled rats and decreased after DN lesions. GAD 65 commonly appears localized at nerve terminals and synapses, and it is only activated when GABA neurotransmission occurs. Thus, it is possible that the increased expression of GAD 65 found in kindled rats could be due to an exacerbated demand for GABA due to kindled seizures. It is known that GABA maintains the inhibitory tone that counterbalances neuronal excitation. The decreased expression of GAD 65 found after the DN lesions indicated that the GABA-synthesizing enzyme was no longer required once it eliminated the excitatory glutamate input to the RN. We thus conclude that DN lesions and their consequent biochemical changes are capable of decreasing the generalized seizures induced by kindling stimulation. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90279122"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/90279122/Modelos_Experimentales_De_Epilepsia"><img alt="Research paper thumbnail of Modelos Experimentales De Epilepsia" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/90279122/Modelos_Experimentales_De_Epilepsia">Modelos Experimentales De Epilepsia</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90279122"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90279122"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90279122; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90279122]").text(description); $(".js-view-count[data-work-id=90279122]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90279122; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90279122']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90279122]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90279122,"title":"Modelos Experimentales De Epilepsia","internal_url":"https://www.academia.edu/90279122/Modelos_Experimentales_De_Epilepsia","owner_id":32300159,"coauthors_can_edit":true,"owner":{"id":32300159,"first_name":"Carlos","middle_initials":null,"last_name":"Tres","page_name":"CarlosTres","domain_name":"unam","created_at":"2015-06-17T16:57:13.353-07:00","display_name":"Carlos Tres","url":"https://unam.academia.edu/CarlosTres"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90279119"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/90279119/Exposure_to_ozone_induces_a_systemic_inflammatory_response_possible_source_of_the_neurological_alterations_induced_by_this_gas"><img alt="Research paper thumbnail of Exposure to ozone induces a systemic inflammatory response: possible source of the neurological alterations induced by this gas" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/90279119/Exposure_to_ozone_induces_a_systemic_inflammatory_response_possible_source_of_the_neurological_alterations_induced_by_this_gas">Exposure to ozone induces a systemic inflammatory response: possible source of the neurological alterations induced by this gas</a></div><div class="wp-workCard_item"><span>Inhalation Toxicology</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The World Health Organization identified urban outdoor air pollution as the eighth highest mortal...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The World Health Organization identified urban outdoor air pollution as the eighth highest mortality risk factor in high-income countries. Exposure to ambient pollutants such as ozone (O3) increases the number of hospital admissions. O3 is a highly reactive gas that reacts with cells lining the airways, producing the formation of reactive oxygen species and inflammation. Beyond the respiratory system, O3 exposure also produces fatigue, lethargy, headaches, and significant decrease in rapid-eye-movement sleep related to an increase in slow-wave sleep. Interestingly, these sleep changes can be significantly mitigated by treatment with indomethacin, which suggests that an inflammatory mechanism may be responsible for these neurological symptoms. To characterize the inflammatory mechanisms by which O3 affects tissues outside the pulmonary system, we evaluated inflammatory factors in both lung and brain. Rats exposed to 1 part per million O3 for 1, 3 or 6 h, as well as rats exposed daily for 1 or 3 h over five consecutive days, showed increases in TNF-α and IL-6 levels within the lungs as well as increases in TNF-α, IL-6, NF-κB p50 and GFAP levels in the cerebral cortex. These results support the hypothesis that the neuroinflammatory response may be responsible for the central nervous system effects of O3 exposure.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90279119"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90279119"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90279119; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90279119]").text(description); $(".js-view-count[data-work-id=90279119]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90279119; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90279119']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="90278344"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/90278344/The_effects_of_ozone_exposure_and_associated_injury_mechanisms_on_the_central_nervous_system"><img alt="Research paper thumbnail of The effects of ozone exposure and associated injury mechanisms on the central nervous system" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/90278344/The_effects_of_ozone_exposure_and_associated_injury_mechanisms_on_the_central_nervous_system">The effects of ozone exposure and associated injury mechanisms on the central nervous system</a></div><div class="wp-workCard_item"><span>Reviews in the Neurosciences</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ozone (O3) is a component of photochemical smog, which is a major air pollutant and demonstrates ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ozone (O3) is a component of photochemical smog, which is a major air pollutant and demonstrates properties that are harmful to health because of the toxic properties that are inherent to its powerful oxidizing capabilities. Environmental O3 exposure is associated with many symptoms related to respiratory disorders, which include loss of lung function, exacerbation of asthma, airway damage, and lung inflammation. The effects of O3 are not restricted to the respiratory system or function - adverse effects within the central nervous system (CNS) such as decreased cognitive response, decrease in motor activity, headaches, disturbances in the sleep-wake cycle, neuronal dysfunctions, cell degeneration, and neurochemical alterations have also been described; furthermore, it has also been proposed that O3 could have epigenetic effects. O3 exposure induces the reactive chemical species in the lungs, but the short half-life of these chemical species has led some authors to attribute the injurious mechanisms observed within the lungs to inflammatory processes. However, the damage to the CNS induced by O3 exposure is not well understood. In this review, the basic mechanisms of inflammation and activation of the immune system by O3 exposure are described and the potential mechanisms of damage, which include neuroinflammation and oxidative stress, and the signs and symptoms of disturbances within the CNS caused by environmental O3 exposure are discussed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90278344"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90278344"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90278344; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90278344]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90278344,"title":"The effects of ozone exposure and associated injury mechanisms on the central nervous system","internal_url":"https://www.academia.edu/90278344/The_effects_of_ozone_exposure_and_associated_injury_mechanisms_on_the_central_nervous_system","owner_id":32300159,"coauthors_can_edit":true,"owner":{"id":32300159,"first_name":"Carlos","middle_initials":null,"last_name":"Tres","page_name":"CarlosTres","domain_name":"unam","created_at":"2015-06-17T16:57:13.353-07:00","display_name":"Carlos Tres","url":"https://unam.academia.edu/CarlosTres"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90278343"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90278343/Whole_brain_irradiation_increases_NREM_sleep_and_hypothalamic_expression_of_IL_1%CE%B2_in_rats"><img alt="Research paper thumbnail of Whole-brain irradiation increases NREM sleep and hypothalamic expression of IL-1β in rats" class="work-thumbnail" src="https://attachments.academia-assets.com/93885230/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90278343/Whole_brain_irradiation_increases_NREM_sleep_and_hypothalamic_expression_of_IL_1%CE%B2_in_rats">Whole-brain irradiation increases NREM sleep and hypothalamic expression of IL-1β in rats</a></div><div class="wp-workCard_item"><span>International Journal of Radiation Biology</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2d69b6512f332b6723467cbfbbd41590" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93885230,"asset_id":90278343,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93885230/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90278343"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90278343"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90278343; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90278343]").text(description); $(".js-view-count[data-work-id=90278343]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90278343; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90278343']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90278342"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90278342/Sleep_and_brain_monoamine_changes_produced_by_acute_and_chronic_acetaldehyde_administration_in_rats"><img alt="Research paper thumbnail of Sleep and brain monoamine changes produced by acute and chronic acetaldehyde administration in rats" class="work-thumbnail" src="https://attachments.academia-assets.com/93885244/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90278342/Sleep_and_brain_monoamine_changes_produced_by_acute_and_chronic_acetaldehyde_administration_in_rats">Sleep and brain monoamine changes produced by acute and chronic acetaldehyde administration in rats</a></div><div class="wp-workCard_item"><span>Behavioural Brain Research</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Acetaldehyde, the most toxic metabolite of ethanol, has been implicated in many toxic effects of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Acetaldehyde, the most toxic metabolite of ethanol, has been implicated in many toxic effects of ethanol. In the present study, we used rats to investigate the possible changes on the sleep-wake cycle and brain regional concentrations of noradrenaline and serotonin after intraperitoneal administration of several doses of acetaldehyde. Results showed that acetaldehyde significantly decreases the time spent in rapid eye movements sleep and wakefulness and increases the time spent in slow-wave sleep. The neurochemical analysis showed that acetaldehyde significantly increases the 5-hydroxyindolacetic acid content and 5-hydroxyindolacetic acid/serotonin ratio at the bulb and pons. These results suggest that acetaldehyde modifies the metabolism of serotonin which has been implicated in the onset and sustaining of the sleep episodes occurring along the sleep-wake cycle.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="518e7e7d9304238c2cb6460c668a8409" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93885244,"asset_id":90278342,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93885244/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90278342"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90278342"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90278342; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90278108"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90278108/Surgical_alternatives_for_the_control_of_epileptic_seizures"><img alt="Research paper thumbnail of Surgical alternatives for the control of epileptic seizures" class="work-thumbnail" src="https://attachments.academia-assets.com/93885048/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90278108/Surgical_alternatives_for_the_control_of_epileptic_seizures">Surgical alternatives for the control of epileptic seizures</a></div><div class="wp-workCard_item"><span>Neurology and Neurosurgery</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Patients with medically intractable epilepsy are candidates for surgical treatment. The main goal...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Patients with medically intractable epilepsy are candidates for surgical treatment. The main goals of treatment consist in the ablation of epileptogenic areas, surgical sectioning of the corpus callosum in order to avoid interhemispheric transmission of epileptic electrical activity and stimulation of brain areas capable of inducing inhibition of epileptic activity. Another alternative is the injury of structures such as the dentate nucleus of the cerebellum, which has shown beneficial effects in patients. However, most of these surgical treatments involve healthy brain areas and implicate excessive costs. In this review we discuss previous works that describe surgical techniques and their main post-surgical complications.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f34dd0c5764baab4d123f8ba841863ec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93885048,"asset_id":90278108,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93885048/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90278108"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90278108"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90278108; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=59518598]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":59518598,"title":"Metformin Plus Caloric Restriction Show Anti-epileptic Effects Mediated by mTOR Pathway Inhibition","internal_url":"https://www.academia.edu/59518598/Metformin_Plus_Caloric_Restriction_Show_Anti_epileptic_Effects_Mediated_by_mTOR_Pathway_Inhibition","owner_id":32300159,"coauthors_can_edit":true,"owner":{"id":32300159,"first_name":"Carlos","middle_initials":null,"last_name":"Tres","page_name":"CarlosTres","domain_name":"unam","created_at":"2015-06-17T16:57:13.353-07:00","display_name":"Carlos Tres","url":"https://unam.academia.edu/CarlosTres"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="59518587"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/59518587/Systemic_inflammation_and_neuronal_dysfunction_produced_by_ozone_exposure"><img alt="Research paper thumbnail of Systemic inflammation and neuronal dysfunction produced by ozone exposure" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/59518587/Systemic_inflammation_and_neuronal_dysfunction_produced_by_ozone_exposure">Systemic inflammation and neuronal dysfunction produced by ozone exposure</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="59518587"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="59518587"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 59518587; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=59518587]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":59518587,"title":"Systemic inflammation and neuronal dysfunction produced by ozone exposure","internal_url":"https://www.academia.edu/59518587/Systemic_inflammation_and_neuronal_dysfunction_produced_by_ozone_exposure","owner_id":32300159,"coauthors_can_edit":true,"owner":{"id":32300159,"first_name":"Carlos","middle_initials":null,"last_name":"Tres","page_name":"CarlosTres","domain_name":"unam","created_at":"2015-06-17T16:57:13.353-07:00","display_name":"Carlos Tres","url":"https://unam.academia.edu/CarlosTres"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="59518581"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/59518581/Caloric_restriction_protects_against_electrical_kindling_of_the_amygdala_by_inhibiting_the_mTOR_signaling_pathway"><img alt="Research paper thumbnail of Caloric restriction protects against electrical kindling of the amygdala by inhibiting the mTOR signaling pathway" class="work-thumbnail" src="https://attachments.academia-assets.com/73400036/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/59518581/Caloric_restriction_protects_against_electrical_kindling_of_the_amygdala_by_inhibiting_the_mTOR_signaling_pathway">Caloric restriction protects against electrical kindling of the amygdala by inhibiting the mTOR signaling pathway</a></div><div class="wp-workCard_item"><span>Frontiers in Cellular Neuroscience</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">KG (2015) Caloric restriction protects against electrical kindling of the amygdala by inhibiting ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">KG (2015) Caloric restriction protects against electrical kindling of the amygdala by inhibiting the mTOR signaling pathway.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5101a439dd860d8392fc853f6163c15e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":73400036,"asset_id":59518581,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/73400036/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="59518581"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="59518581"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 59518581; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="59518573"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/59518573/Quinine_a_selective_gap_junction_blocker_decreases_REM_sleep_in_rats"><img alt="Research paper thumbnail of Quinine, a selective gap junction blocker, decreases REM sleep in rats" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/59518573/Quinine_a_selective_gap_junction_blocker_decreases_REM_sleep_in_rats">Quinine, a selective gap junction blocker, decreases REM sleep in rats</a></div><div class="wp-workCard_item"><span>Pharmacology Biochemistry and Behavior</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Electrical synapses are formed by gap junctions that allow the direct communication between neuro...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Electrical synapses are formed by gap junctions that allow the direct communication between neurons, the intercellular transference of ions and small molecules as well as the electrical coupling of the cells. Electrical coupling in neurons is mediated by the gap junction protein connexin36. There are reports about the presence of electrical coupling in the sublaterodorsal nucleus and pedunculopontine nucleus, which have been implicated in the modulation of the rapid eye movement sleep. In the present study, rats were used to examine the possible changes on the sleep-wake states after intracerebroventricular administration of several doses of quinine, a selective blocker of gap junctions formed by connexin36. The results showed that quinine significantly increased the time spent in wakefulness and decreased the time spent in slow wave sleep along the 24h of polygraphic recording. The three doses used of quinine caused a significant decrease of rapid eye movement sleep along the light phase; however, only one dose extended such effect until the darkness phase. The changes on sleep-wake states of the rat after the blockage of gap junctions formed by connexin36 suggest that electrical synapses could contribute to the regulation of sleep-wake states in concert with the well-known chemical neurotransmission.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="59518573"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="59518573"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 59518573; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=59518573]").text(description); $(".js-view-count[data-work-id=59518573]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 59518573; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='59518573']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=59518573]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":59518573,"title":"Quinine, a selective gap junction blocker, decreases REM sleep in rats","internal_url":"https://www.academia.edu/59518573/Quinine_a_selective_gap_junction_blocker_decreases_REM_sleep_in_rats","owner_id":32300159,"coauthors_can_edit":true,"owner":{"id":32300159,"first_name":"Carlos","middle_initials":null,"last_name":"Tres","page_name":"CarlosTres","domain_name":"unam","created_at":"2015-06-17T16:57:13.353-07:00","display_name":"Carlos Tres","url":"https://unam.academia.edu/CarlosTres"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="59518566"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/59518566/PVN_electrical_stimulation_prolongs_withdrawal_latencies_and_releases_oxytocin_in_cerebrospinal_fluid_plasma_and_spinal_cord_tissue_in_intact_and_neuropathic_rats"><img alt="Research paper thumbnail of PVN electrical stimulation prolongs withdrawal latencies and releases oxytocin in cerebrospinal fluid, plasma, and spinal cord tissue in intact and neuropathic rats" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/59518566/PVN_electrical_stimulation_prolongs_withdrawal_latencies_and_releases_oxytocin_in_cerebrospinal_fluid_plasma_and_spinal_cord_tissue_in_intact_and_neuropathic_rats">PVN electrical stimulation prolongs withdrawal latencies and releases oxytocin in cerebrospinal fluid, plasma, and spinal cord tissue in intact and neuropathic rats</a></div><div class="wp-workCard_item"><span>PAIN</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We are studying an endogenous, oxytocinergic analgesia system to obtain more information about no...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We are studying an endogenous, oxytocinergic analgesia system to obtain more information about normal and pathological pain processes. In the recent years, this oxytocinergic system has been shown to be involved in normal and pathological pain suppression. The paraventricular nucleus (PVN) of the hypothalamus is an important source of brain oxytocin (OT). A descending pathway reaching the dorsal horn in the spinal cord was postulated to mediate analgesic effects at the spinal cord level. However, the oxytocin concentration during pain conditions and during PVN electrical stimulation needs to be determined. We designed experiments to measure the OT concentration in cerebrospinal fluid (CSF), plasma, and OT protein in lumbar spinal cord tissue in control and neuropathic rats. Sciatic loose ligature was used as the experimental method to produce neuropathic pain. The main findings were (1) Chronic pain experiments in animals showed that the stimulation of the anterior part of the PVN increased OT concentration and produced analgesia states, as measured by von Frey, cold, and heat plantar tests. (2) Differential effects were produced by electrical stimulation of the anterior or posterior regions of the PVN; electrical stimulation of the anterior part of the PVN enhanced the OT concentration in CSF and plasma, and it also increased OT protein concentrations in the spinal cord tissue; in contrast, the stimulation of the posterior part of the PVN only increased OT concentrations in CSF. These results suggest the participation of an endogenous analgesia system mediated by OT.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="59518566"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="59518566"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 59518566; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=59518566]").text(description); 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=59518566]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":59518566,"title":"PVN electrical stimulation prolongs withdrawal latencies and releases oxytocin in cerebrospinal fluid, plasma, and spinal cord tissue in intact and neuropathic rats","internal_url":"https://www.academia.edu/59518566/PVN_electrical_stimulation_prolongs_withdrawal_latencies_and_releases_oxytocin_in_cerebrospinal_fluid_plasma_and_spinal_cord_tissue_in_intact_and_neuropathic_rats","owner_id":32300159,"coauthors_can_edit":true,"owner":{"id":32300159,"first_name":"Carlos","middle_initials":null,"last_name":"Tres","page_name":"CarlosTres","domain_name":"unam","created_at":"2015-06-17T16:57:13.353-07:00","display_name":"Carlos Tres","url":"https://unam.academia.edu/CarlosTres"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="59518558"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/59518558/Initial_experience_in_Brazil_with_the_Helex_septal_occluder_for_percutaneous_occlusion_of_atrial_septal_defects"><img alt="Research paper thumbnail of Initial experience in Brazil with the Helex septal occluder for percutaneous occlusion of atrial septal defects" class="work-thumbnail" src="https://attachments.academia-assets.com/73400041/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/59518558/Initial_experience_in_Brazil_with_the_Helex_septal_occluder_for_percutaneous_occlusion_of_atrial_septal_defects">Initial experience in Brazil with the Helex septal occluder for percutaneous occlusion of atrial septal defects</a></div><div class="wp-workCard_item"><span>Arquivos Brasileiros de Cardiologia</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the last 10-15 years, major advances in the percutaneous treatment of atrial septal defects wi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the last 10-15 years, major advances in the percutaneous treatment of atrial septal defects with the use of several occluding devices has occurred with progressive improvement in the results 1-14. Because this approach currently provides excellent occlusive results with minimum morbidity and mortality in short and medium follow-up with obvious advantages regarding the surgical approach 8-17 , it is considered the method of choice for the treatment of selected patients in several medical centers around the world. However, some devices have not been widely accepted by interventionists because they possess characteristics far from those considered ideal 1-7. The most commonly used, including in our group, are the Amplatzer Septal Occluder (AGA Medical Corporation, Golden Valley, MN) 10-16 the CardioSEAL septal occluder and the STARFlex (Nitinol Medical Technologies, Boston, MA) 8,9. Recently, a new device, the Helex septal occluder (W.L. Gore and Associates, Flagstaff, AZ) was introduced for clinical use after encouraging results from experimental studies 18. We report herein the initial experience at 2 Brazilian centers with the new Helex device. Methods The Helex septal occluder is composed of a single flexible nitinol wire frame tridimensionally helically shaped, with a 0.012-inch diameter, covered with a thin polytetrafluoroethylene membrane (PTFE better known as Gore-Tex) (fig.1). For implantation, the frame is sealed in a central mandrel and pulled inside a delivery catheter (9F) (fig 1). As the device is extruded from the catheter, it assumes a helicoidal configuration (therefore the name Helex). It is composed of 2 flexible disks with round borders that are positioned through the hole within the septum. The Helex septal occluder is available on the market in 5 diameters, 15 to 35mm, in 5mm increments. Three small metal loops also called "eyelets" are found in the center of the disks, one more distal (outside the disk on the left side), one between the 2 disks, and another proximal, (outside the disk on the right side). Within the proximal waist is a retrieval cord made of polytetrafluoroethylene 18,19. Objective-To evaluate the initial clinical experience with the Helex septal occluder for percutaneous closure of atrial septal defects. Methods-Ten patients underwent the procedure, 7 patients with ostium secundum atrial septal defects (ASD) with hemodynamic repercussions and 3 patients with pervious foramen ovale (PFO) and a history of stroke. Mean age was 33.8 years and mean weight was 55.4 kg. Mean diameter by transesophageal echocardiography and mean stretched ASD diameter were 11.33 ± 3.3mm, and 15.2 ± 3.8mm, respectively. The Qp/Qs ratio was 1.9 ± 0.3 in patients with ASD. Results-Eleven occluders were placed because a patient with 2 holes needed 2 devices. It was necessary to retrieve and replace 4 devices in 3 patients. We observed immediate residual shunt (< 2mm) in 4 patients with ASD, and in those with patent foramen ovale total occlusion of the defect occurred. No complications were noted, and all patients were discharged on the following day. After 1 month, 2 patients with ASD experienced trivial residual shunts (1mm). In 1 patient, we observed mild prolapse in the proximal disk in the right atrium, without consequences. Conclusion-The Helex septal occluder was safe and effective for occluding small to moderate atrial septal defects. Because the implantation technique is demanding, it requires specific training of the operator. Even so, small technical failures may occur in the beginning of the learning curve, but they do not involve patient safety.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fd1991cef8130ef1645b3de58ad0ce35" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":73400041,"asset_id":59518558,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/73400041/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="59518558"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="59518558"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 59518558; 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