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<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="BXIFbD1Yk84JC//CcPp9eFpu3+pfcEPR3mJ4LeXB4j0t4nFRadnKsQzv/mcEv3XFnv2rug8ZmiURNn4r78Rlqg==" /> <meta name="citation_title" content="Hypopituitarism due to sports related head trauma and the effects of growth hormone replacement in retired amateur boxers" /> <meta name="citation_publication_date" content="2010/01/01" /> <meta name="citation_journal_title" content="Pituitary" /> <meta name="citation_author" content="Züleyha Karaca" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/25476721/Hypopituitarism_due_to_sports_related_head_trauma_and_the_effects_of_growth_hormone_replacement_in_retired_amateur_boxers" /> <meta name="twitter:title" content="Hypopituitarism due to sports related head trauma and the effects of growth hormone replacement in retired amateur boxers" /> <meta name="twitter:description" content="Traumatic brain injury (TBI) has been recently recognized as a leading cause of pituitary dysfunction. Current data clearly demonstrated that sports related head trauma due to boxing, kickboxing, and soccer might results in pituitary hormone" /> <meta name="twitter:image" content="http://a.academia-assets.com/images/twitter-card.jpeg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/25476721/Hypopituitarism_due_to_sports_related_head_trauma_and_the_effects_of_growth_hormone_replacement_in_retired_amateur_boxers" /> <meta property="og:title" content="Hypopituitarism due to sports related head trauma and the effects of growth hormone replacement in retired amateur boxers" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="Traumatic brain injury (TBI) has been recently recognized as a leading cause of pituitary dysfunction. Current data clearly demonstrated that sports related head trauma due to boxing, kickboxing, and soccer might results in pituitary hormone" /> <meta property="article:author" content="https://independent.academia.edu/Z%C3%BCleyhaKaraca" /> <meta name="description" content="Traumatic brain injury (TBI) has been recently recognized as a leading cause of pituitary dysfunction. Current data clearly demonstrated that sports related head trauma due to boxing, kickboxing, and soccer might results in pituitary hormone" /> <title>(PDF) Hypopituitarism due to sports related head trauma and the effects of growth hormone replacement in retired amateur boxers | Züleyha Karaca - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/25476721/Hypopituitarism_due_to_sports_related_head_trauma_and_the_effects_of_growth_hormone_replacement_in_retired_amateur_boxers" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '533b30f8414e20088f06d207ddf582bca83ea18e'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732759898000); window.Aedu.timeDifference = new Date().getTime() - 1732759898000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Traumatic brain injury (TBI) has been recently recognized as a leading cause of pituitary dysfunction. Current data clearly demonstrated that sports related head trauma due to boxing, kickboxing, and soccer might results in pituitary hormone deficiencies, isolated growth hormone (GH) deficiency in particular. In the present report physiologic dose GH replacement therapy (GHRT) was performed in two GH deficient retired amateur boxers for the first time. The boxers received recombinant GH for 6 months. After 6 months of GHRT there were substantial improvements, but not complete normalization, in the body composition parameters, lipid profiles and quality of life scores in both boxers. These preliminary results suggest that GHRT may have beneficial effects in retired boxers with severe isolated GH deficiency due to sports related head trauma. But more data with higher number of boxers and longer GHRT duration are warranted.","author":[{"@context":"https://schema.org","@type":"Person","name":"Züleyha Karaca"}],"contributor":[],"dateCreated":"2016-05-19","dateModified":"2016-05-24","datePublished":"2010-01-01","headline":"Hypopituitarism due to sports related head trauma and the effects of growth hormone replacement in retired amateur boxers","inLanguage":"en","keywords":["Traumatic Brain Injury","Magnetic Resonance Imaging","Quality of life","Boxing","Growth Hormone","Humans","Human Growth Hormone","Body Composition","Male","Hypopituitarism","Pituitary Gland","Adult","Adrenocorticotropic Hormone","Lipid Profile","Pituitary","Head Trauma"],"locationCreated":null,"publication":"Pituitary","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/25476721/Hypopituitarism_due_to_sports_related_head_trauma_and_the_effects_of_growth_hormone_replacement_in_retired_amateur_boxers","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-102fa537001ba4d8dcd921ad9bd56c474abc201906ea4843e7e7efe9dfbf561d.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-8d679e925718b5e8e4b18e9a4fab37f7eaa99e43386459376559080ac8f2856a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link rel="stylesheet" media="all" 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Current data clearly demonstrated that sports related head trauma due to boxing, kickboxing, and soccer might results in pituitary hormone deficiencies, isolated growth hormone (GH) deficiency in particular. In the present report physiologic dose GH replacement therapy (GHRT) was performed in two GH deficient retired amateur boxers for the first time. The boxers received recombinant GH for 6 months. After 6 months of GHRT there were substantial improvements, but not complete normalization, in the body composition parameters, lipid profiles and quality of life scores in both boxers. These preliminary results suggest that GHRT may have beneficial effects in retired boxers with severe isolated GH deficiency due to sports related head trauma. 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const worksViewsPath = "/v0/works/views?subdomain_param=api&work_ids%5B%5D=25476721"; const getWorkViews = async (workId) => { const response = await fetch(worksViewsPath); if (!response.ok) { throw new Error('Failed to load work views'); } const data = await response.json(); return data.views[workId]; }; // Get the view count for the work - we send this immediately rather than waiting for // the DOM to load, so it can be available as soon as possible (but without holding up // the backend or other resource requests, because it's a bit expensive and not critical). const viewCount = await getWorkViews(workId); const updateViewCount = (viewCount) => { const viewCountNumber = Number(viewCount); if (!viewCountNumber) { throw new Error('Failed to parse view count'); } const commaizedViewCount = viewCountNumber.toLocaleString(); const viewCountBody = document.getElementById('work-metadata-view-count'); if (viewCountBody) { viewCountBody.textContent = `${commaizedViewCount} views`; } else { throw new Error('Failed to find work views element'); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Traumatic brain injury (TBI) has been recently recognized as a leading cause of pituitary dysfunction. Current data clearly demonstrated that sports related head trauma due to boxing, kickboxing, and soccer might results in pituitary hormone deficiencies, isolated growth hormone (GH) deficiency in particular. In the present report physiologic dose GH replacement therapy (GHRT) was performed in two GH deficient retired amateur boxers for the first time. The boxers received recombinant GH for 6 months. After 6 months of GHRT there were substantial improvements, but not complete normalization, in the body composition parameters, lipid profiles and quality of life scores in both boxers. These preliminary results suggest that GHRT may have beneficial effects in retired boxers with severe isolated GH deficiency due to sports related head trauma. But more data with higher number of boxers and longer GHRT duration are warranted.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":45794895,"attachmentType":"pdf","workUrl":"https://www.academia.edu/25476721/Hypopituitarism_due_to_sports_related_head_trauma_and_the_effects_of_growth_hormone_replacement_in_retired_amateur_boxers"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":45794895,"attachmentType":"pdf","workUrl":"https://www.academia.edu/25476721/Hypopituitarism_due_to_sports_related_head_trauma_and_the_effects_of_growth_hormone_replacement_in_retired_amateur_boxers"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="45794895" data-landing_url="https://www.academia.edu/25476721/Hypopituitarism_due_to_sports_related_head_trauma_and_the_effects_of_growth_hormone_replacement_in_retired_amateur_boxers" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="12788573" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/12788573/Hypopituitarism_and_growth_hormone_deficiency_GHD_after_traumatic_brain_injury_TBI_">Hypopituitarism and growth hormone deficiency (GHD) after traumatic brain injury (TBI)</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31857899" href="https://uniba-it.academia.edu/FrancescoLogoluso">Francesco Logoluso</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Growth Hormone & Igf Research, 2004</p><p class="ds-related-work--abstract ds2-5-body-sm">In adults, hypopituitarism and growth hormone deficiency (GHD) should be suspected and diagnosed within an appropriate clinical context. 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deficiency due to sports-related head trauma is associated with impaired cognitive performance in amateur boxers and kickboxers as revealed by P300 auditory event-related potentials</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="49116412" href="https://independent.academia.edu/KUnluhizarci">K. Unluhizarci</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinical Endocrinology, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Growth hormone deficiency due to sports-related head trauma is associated with impaired cognitive performance in amateur boxers and kickboxers as revealed by P300 auditory event-related potentials","attachmentId":82379202,"attachmentType":"pdf","work_url":"https://www.academia.edu/74108435/Growth_hormone_deficiency_due_to_sports_related_head_trauma_is_associated_with_impaired_cognitive_performance_in_amateur_boxers_and_kickboxers_as_revealed_by_P300_auditory_event_related_potentials","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/74108435/Growth_hormone_deficiency_due_to_sports_related_head_trauma_is_associated_with_impaired_cognitive_performance_in_amateur_boxers_and_kickboxers_as_revealed_by_P300_auditory_event_related_potentials"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="3990177" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/3990177/Growth_hormone_deficient_patients_after_traumatic_brain_injury_Baseline_characteristics_and_benefits_after_growth_hormone_replacement_An_analysis_of_the_German_KIMS_database">Growth hormone deficient patients after traumatic brain injury – Baseline characteristics and benefits after growth hormone replacement – An analysis of the German KIMS database</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="162995" href="https://uni-trier.academia.edu/EvaPoll">Eva Poll</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Growth Hormone & Igf Research, 2008</p><p class="ds-related-work--abstract ds2-5-body-sm">In recent years, traumatic brain injury (TBI) has been identified as a significant cause of growth hormone deficiency (GHD). The aim of the present study was to characterize adult TBI patients with GHD to elucidate the effect of human growth hormone (hGH) replacement in TBI patients as documented in the German Pfizer International Metabolic (KIMS) database.As of October 2006, 84 TBI patients had been included in the German KIMS database (n = 28 childhood-onset and 54 adult-onset GHD). All 84 TBI patients were matched with 84 patients with GHD due to non-functioning pituitary adenoma (NFPA) also included in this database. Analysis of clinical and outcome variables was performed, with comparisons of childhood vs. adult TBI, and TBI vs. NFPA patients, at baseline and one-year follow-up.TBI patients with GHD were significantly younger at the onset of pituitary disease and exhibited a significantly longer time span between GHD diagnosis and KIMS entry than NFPA patients. Those KIMS patients who had sustained their TBI in childhood were of significantly shorter stature than adult-onset TBI patients. At 1-year follow-up, insulin-like growth factor I (IGF-I) standard deviation score levels had returned to the normal range and quality of life (QoL), as measured by QoL- Assessment of Growth Hormone Deficiency in Adults (AGHDA) questionnaire, improved significantly in TBI as in NFPA patients.This analysis provides preliminary data that TBI patients with GHD benefit from hGH replacement in terms of improved QoL in a similar fashion as do NFPA patients. Moreover, it suggests that belated diagnosis and treatment in childhood-onset GHD due to TBI might be related to a shorter final height in these children.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Growth hormone deficient patients after traumatic brain injury – Baseline characteristics and benefits after growth hormone replacement – An analysis of the German KIMS database","attachmentId":50095036,"attachmentType":"pdf","work_url":"https://www.academia.edu/3990177/Growth_hormone_deficient_patients_after_traumatic_brain_injury_Baseline_characteristics_and_benefits_after_growth_hormone_replacement_An_analysis_of_the_German_KIMS_database","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/3990177/Growth_hormone_deficient_patients_after_traumatic_brain_injury_Baseline_characteristics_and_benefits_after_growth_hormone_replacement_An_analysis_of_the_German_KIMS_database"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="50341228" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/50341228/Investigation_of_Pituitary_Dysfunction_in_Retired_Professional_Soccer_Players">Investigation of Pituitary Dysfunction in Retired Professional Soccer Players</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="41672306" href="https://independent.academia.edu/SonerAkkurt">Soner Akkurt</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Revista Brasileira de Medicina do Esporte</p><p class="ds-related-work--abstract ds2-5-body-sm">Introduction: It is well-known that pituitary dysfunction can develop as a result of traumatic brain injuries. One reason for such injuries is collision during contact sports. Objectives: The aim of this study was to investigate the effects of heading the ball and concussion on pituitary function in retired soccer players. Methods: Thirty-two retired soccer players, with an average age of 43.38 ± 5.49 (35-59) and 26 sedentary individuals with an average age of 43.31±6.38 (35-59) were included in this study. The subjects were questioned about their soccer-playing background, history of head trauma and concussion, and cardiometabolic diseases. One day one, blood samples were taken to investigate the baseline hematologic and biochemical parameters. On day two, the ACTH stimulation test was conducted, and on day three, glucagon stimulation tests were carried out. Resting EKG, transthoracic ECHO and exercise stress tests (for MET values) were also conducted. For the statistical analysis,...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Investigation of Pituitary Dysfunction in Retired Professional Soccer Players","attachmentId":68364674,"attachmentType":"pdf","work_url":"https://www.academia.edu/50341228/Investigation_of_Pituitary_Dysfunction_in_Retired_Professional_Soccer_Players","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/50341228/Investigation_of_Pituitary_Dysfunction_in_Retired_Professional_Soccer_Players"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="24820812" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/24820812/Traumatic_Brain_Injury_in_Children_and_Adolescents_Surveillance_for_Pituitary_Dysfunction">Traumatic Brain Injury in Children and Adolescents: Surveillance for Pituitary Dysfunction</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47859399" href="https://independent.academia.edu/MarkDeboer1">Mark Deboer</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47923979" href="https://independent.academia.edu/NorwoodK">Kenneth Norwood</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47894259" href="https://virginia.academia.edu/MarciaBuck">Marcia Buck</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinical Pediatrics, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Traumatic Brain Injury in Children and Adolescents: Surveillance for Pituitary Dysfunction","attachmentId":45146474,"attachmentType":"pdf","work_url":"https://www.academia.edu/24820812/Traumatic_Brain_Injury_in_Children_and_Adolescents_Surveillance_for_Pituitary_Dysfunction","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/24820812/Traumatic_Brain_Injury_in_Children_and_Adolescents_Surveillance_for_Pituitary_Dysfunction"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="13628086" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13628086/Pituitary_Function_and_Functional_Outcome_in_Adults_after_Severe_Traumatic_Brain_Injury_The_Long_Term_Perspective">Pituitary Function and Functional Outcome in Adults after Severe Traumatic Brain Injury: The Long-Term Perspective</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32791147" href="https://independent.academia.edu/ChristianBlomstrand">Christian Blomstrand</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Neurotrauma, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Pituitary Function and Functional Outcome in Adults after Severe Traumatic Brain Injury: The Long-Term Perspective","attachmentId":45132563,"attachmentType":"pdf","work_url":"https://www.academia.edu/13628086/Pituitary_Function_and_Functional_Outcome_in_Adults_after_Severe_Traumatic_Brain_Injury_The_Long_Term_Perspective","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13628086/Pituitary_Function_and_Functional_Outcome_in_Adults_after_Severe_Traumatic_Brain_Injury_The_Long_Term_Perspective"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":45794895,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":45794895,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download 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You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="89815418" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/89815418/Occurrence_of_Pituitary_Dysfunction_following_Traumatic_Brain_Injury">Occurrence of Pituitary Dysfunction following Traumatic Brain Injury</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="48783815" href="https://independent.academia.edu/MarcelloMonesi">Marcello Monesi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Neurotrauma, 2004</p><div 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class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="66675350" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/66675350/Prevalence_of_Posttraumatic_Growth_Hormone_Deficiency_Is_Highly_Dependent_on_the_Diagnostic_Set_up_Results_From_The_Danish_National_Study_on_Posttraumatic_Hypopituitarism">Prevalence of Posttraumatic Growth Hormone Deficiency Is Highly Dependent on the Diagnostic Set-up: Results From The Danish National Study on Posttraumatic Hypopituitarism</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33505429" href="https://ku-dk.academia.edu/UllaFeldtrasmussen">Ulla Feldt-rasmussen</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Clinical Endocrinology & Metabolism, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Prevalence of Posttraumatic Growth Hormone Deficiency Is Highly Dependent on the Diagnostic Set-up: Results From The Danish National Study on Posttraumatic Hypopituitarism","attachmentId":77774957,"attachmentType":"pdf","work_url":"https://www.academia.edu/66675350/Prevalence_of_Posttraumatic_Growth_Hormone_Deficiency_Is_Highly_Dependent_on_the_Diagnostic_Set_up_Results_From_The_Danish_National_Study_on_Posttraumatic_Hypopituitarism","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/66675350/Prevalence_of_Posttraumatic_Growth_Hormone_Deficiency_Is_Highly_Dependent_on_the_Diagnostic_Set_up_Results_From_The_Danish_National_Study_on_Posttraumatic_Hypopituitarism"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="91378576" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/91378576/Utility_of_serum_IGF_1_for_diagnosis_of_growth_hormone_deficiency_following_traumatic_brain_injury_and_sport_related_concussion">Utility of serum IGF-1 for diagnosis of growth hormone deficiency following traumatic brain injury and sport-related concussion</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="233535937" href="https://independent.academia.edu/AlexChin58">Alex Chin</a></div><p class="ds-related-work--metadata ds2-5-body-xs">BMC Endocrine Disorders, 2018</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Utility of serum IGF-1 for diagnosis of growth hormone deficiency following traumatic brain injury and sport-related concussion","attachmentId":94682875,"attachmentType":"pdf","work_url":"https://www.academia.edu/91378576/Utility_of_serum_IGF_1_for_diagnosis_of_growth_hormone_deficiency_following_traumatic_brain_injury_and_sport_related_concussion","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a 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Acute Phase and 12 Months after Trauma</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="191885076" href="https://independent.academia.edu/FatihTanr%C4%B1verdi3">Fatih Tanrıverdi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Clinical Endocrinology & Metabolism, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"High Risk of Hypopituitarism after Traumatic Brain Injury: A Prospective Investigation of Anterior Pituitary Function in the Acute Phase and 12 Months after Trauma","attachmentId":71997098,"attachmentType":"pdf","work_url":"https://www.academia.edu/56779231/High_Risk_of_Hypopituitarism_after_Traumatic_Brain_Injury_A_Prospective_Investigation_of_Anterior_Pituitary_Function_in_the_Acute_Phase_and_12_Months_after_Trauma","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/56779231/High_Risk_of_Hypopituitarism_after_Traumatic_Brain_Injury_A_Prospective_Investigation_of_Anterior_Pituitary_Function_in_the_Acute_Phase_and_12_Months_after_Trauma"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="4" data-entity-id="28591128" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/28591128/High_Prevalence_of_Chronic_Pituitary_and_Target_Organ_Hormone_Abnormalities_after_Blast_Related_Mild_Traumatic_Brain_Injury">High Prevalence of Chronic Pituitary and Target-Organ Hormone Abnormalities after Blast-Related Mild Traumatic Brain Injury</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="53628358" href="https://independent.academia.edu/MatthewTarabochia">Matthew Tarabochia</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Frontiers in Neurology, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"High Prevalence of Chronic 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