Search results for: Rosalie Sears

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Sears</title> <meta name="description" content="Search results for: Rosalie Sears"> <meta name="keywords" content="Rosalie Sears"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Rosalie Sears"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 3</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Rosalie Sears</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Computational Approaches to Study Lineage Plasticity in Human Pancreatic Ductal Adenocarcinoma</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Almudena%20Espin%20Perez">Almudena Espin Perez</a>, <a href="https://publications.waset.org/abstracts/search?q=Tyler%20Risom"> Tyler Risom</a>, <a href="https://publications.waset.org/abstracts/search?q=Carl%20Pelz"> Carl Pelz</a>, <a href="https://publications.waset.org/abstracts/search?q=Isabel%20English"> Isabel English</a>, <a href="https://publications.waset.org/abstracts/search?q=Robert%20M.%20Angelo"> Robert M. Angelo</a>, <a href="https://publications.waset.org/abstracts/search?q=Rosalie%20%20Sears"> Rosalie Sears</a>, <a href="https://publications.waset.org/abstracts/search?q=Andrew%20J.%20Gentles"> Andrew J. Gentles</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly malignancies. The role of the tumor microenvironment (TME) is gaining significant attention in cancer research. Despite ongoing efforts, the nature of the interactions between tumors, immune cells, and stromal cells remains poorly understood. The cell-intrinsic properties that govern cell lineage plasticity in PDAC and extrinsic influences of immune populations require technically challenging approaches due to the inherently heterogeneous nature of PDAC. Understanding the cell lineage plasticity of PDAC will improve the development of novel strategies that could be translated to the clinic. Members of the team have demonstrated that the acquisition of ductal to neuroendocrine lineage plasticity in PDAC confers therapeutic resistance and is a biomarker of poor outcomes in patients. Our approach combines computational methods for deconvolving bulk transcriptomic cancer data using CIBERSORTx and high-throughput single-cell imaging using Multiplexed Ion Beam Imaging (MIBI) to study lineage plasticity in PDAC and its relationship to the infiltrating immune system. The CIBERSORTx algorithm uses signature matrices from immune cells and stroma from sorted and single-cell data in order to 1) infer the fractions of different immune cell types and stromal cells in bulked gene expression data and 2) impute a representative transcriptome profile for each cell type. We studied a unique set of 300 genomically well-characterized primary PDAC samples with rich clinical annotation. We deconvolved the PDAC transcriptome profiles using CIBERSORTx, leveraging publicly available single-cell RNA-seq data from normal pancreatic tissue and PDAC to estimate cell type proportions in PDAC, and digitally reconstruct cell-specific transcriptional profiles from our study dataset. We built signature matrices and optimized by simulations and comparison to ground truth data. We identified cell-type-specific transcriptional programs that contribute to cancer cell lineage plasticity, especially in the ductal compartment. We also studied cell differentiation hierarchies using CytoTRACE and predict cell lineage trajectories for acinar and ductal cells that we believe are pinpointing relevant information on PDAC progression. Collaborators (Angelo lab, Stanford University) has led the development of the Multiplexed Ion Beam Imaging (MIBI) platform for spatial proteomics. We will use in the very near future MIBI from tissue microarray of 40 PDAC samples to understand the spatial relationship between cancer cell lineage plasticity and stromal cells focused on infiltrating immune cells, using the relevant markers of PDAC plasticity identified from the RNA-seq analysis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=deconvolution" title="deconvolution">deconvolution</a>, <a href="https://publications.waset.org/abstracts/search?q=imaging" title=" imaging"> imaging</a>, <a href="https://publications.waset.org/abstracts/search?q=microenvironment" title=" microenvironment"> microenvironment</a>, <a href="https://publications.waset.org/abstracts/search?q=PDAC" title=" PDAC"> PDAC</a> </p> <a href="https://publications.waset.org/abstracts/122441/computational-approaches-to-study-lineage-plasticity-in-human-pancreatic-ductal-adenocarcinoma" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/122441.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">128</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Roof Integrated Photo Voltaic with Air Collection on Glasgow School of Art Campus Building: A Feasibility Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rosalie%20Menon">Rosalie Menon</a>, <a href="https://publications.waset.org/abstracts/search?q=Angela%20Reid"> Angela Reid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Building integrated photovoltaic systems with air collectors (hybrid PV-T) have proved successful however there are few examples of their application in the UK. The opportunity to pull heat from behind the PV system to contribute to a building’s heating system is an efficient use of waste energy and its potential to improve the performance of the PV array is well documented. As part of Glasgow School of Art’s estate expansion, the purchase and redevelopment of an existing 1950’s college building was used as a testing vehicle for the hybrid PV-T system as an integrated element of the upper floor and roof. The primary objective of the feasibility study was to determine if hybrid PV-T was technically and financially suitable for the refurbished building. The key consideration was whether the heat recovered from the PV panels (to increase the electrical efficiency) can be usefully deployed as a heat source within the building. Dynamic thermal modelling (IES) and RetScreen Software were used to carry out the feasibility study not only to simulate overshadowing and optimise the PV-T locations but also to predict the atrium temperature profile; predict the air load for the proposed new 4 No. roof mounted air handling units and to predict the dynamic electrical efficiency of the PV element. The feasibility study demonstrates that there is an energy reduction and carbon saving to be achieved with each hybrid PV-T option however the systems are subject to lengthy payback periods and highlights the need for enhanced government subsidy schemes to reward innovation with this technology in the UK. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=building%20integrated" title="building integrated">building integrated</a>, <a href="https://publications.waset.org/abstracts/search?q=photovoltatic%20thermal" title=" photovoltatic thermal"> photovoltatic thermal</a>, <a href="https://publications.waset.org/abstracts/search?q=pre-heat%20air" title=" pre-heat air"> pre-heat air</a>, <a href="https://publications.waset.org/abstracts/search?q=ventilation" title=" ventilation"> ventilation</a> </p> <a href="https://publications.waset.org/abstracts/90259/roof-integrated-photo-voltaic-with-air-collection-on-glasgow-school-of-art-campus-building-a-feasibility-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/90259.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">171</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> The Impact of COVID-19 Health Measures on Adults with Multiple Chemical Sensitivity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Riina%20I.%20Bray">Riina I. Bray</a>, <a href="https://publications.waset.org/abstracts/search?q=Yifan%20Wang"> Yifan Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Nikolas%20Argiropoulos"> Nikolas Argiropoulos</a>, <a href="https://publications.waset.org/abstracts/search?q=Stephanie%20Robins"> Stephanie Robins</a>, <a href="https://publications.waset.org/abstracts/search?q=John%20Molot"> John Molot</a>, <a href="https://publications.waset.org/abstracts/search?q=Kelly%20Tragash"> Kelly Tragash</a>, <a href="https://publications.waset.org/abstracts/search?q=Lynn%20M.%20Marshall"> Lynn M. Marshall</a>, <a href="https://publications.waset.org/abstracts/search?q=Margaret%20E.%20Sears"> Margaret E. Sears</a>, <a href="https://publications.waset.org/abstracts/search?q=Marie-Andr%C3%A9e%20Pigeon"> Marie-Andrée Pigeon</a>, <a href="https://publications.waset.org/abstracts/search?q=Michel%20Gaudet"> Michel Gaudet</a>, <a href="https://publications.waset.org/abstracts/search?q=Pierre%20Auger"> Pierre Auger</a>, <a href="https://publications.waset.org/abstracts/search?q=Emily%20B%C3%A9langer"> Emily Bélanger</a>, <a href="https://publications.waset.org/abstracts/search?q=Rohini%20Peris"> Rohini Peris</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Multiple chemical sensitivity (MCS) is a chronic medical condition characterized by intolerances to chemical substances. Since the arrival of the COVID-19 pandemic and associated health measures, people experiencing MCS (PEMCS) are at a heightened risk of environmental exposures associated with cleaners, disinfectants, and sanitizers. Little attention has been paid to the well-being of PEMCS in the context of the COVID-19 pandemic. Objective: This study assesses the lived experiences of Canadian adults with MCS in relation to their living environment, access to healthcare, and levels of perceived social support before and during the pandemic. Methods: A total of 119 PEMCS completed an online questionnaire. McNemar Chi-Squared and Wilcoxon Signed Rank tests were used to evaluate if there were statistically significant changes in participants’ perception of their living environment, access to healthcare, and levels of social support before and after March 11, 2020. Results: Both positive and negative outcomes were noted. Participants reported an increase in exposure to disinfectants/sanitizers that entered their living environment (p<.001). There was a reported decrease in access to a family doctor during the pandemic (p<0.001). Although PEMCS experienced increased social isolation (p<0.001), they also reported an increase in understanding from family (p<0.029) and a decrease in stigma for wearing personal protective equipment (p<0.001). Conclusion: PEMCS reported experiencing: increased exposure to disinfectants or sanitizers, a loss of social support, and barriers in accessing healthcare during the pandemic. However, COVID-19 provided an opportunity to normalize the living conditions of PEMCS, such as wearing masks and social isolation. These findings can guide decision-makers on the importance of implementing nontoxic alternatives for cleaning and disinfection, as well as improving accommodation measures for PEMCS. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=covid-19" title="covid-19">covid-19</a>, <a href="https://publications.waset.org/abstracts/search?q=multiple%20chemical%20sensitivity" title=" multiple chemical sensitivity"> multiple chemical sensitivity</a>, <a href="https://publications.waset.org/abstracts/search?q=MCS" title=" MCS"> MCS</a>, <a href="https://publications.waset.org/abstracts/search?q=quality%20of%20life" title=" quality of life"> quality of life</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20isolation" title=" social isolation"> social isolation</a>, <a href="https://publications.waset.org/abstracts/search?q=physical%20environment" title=" physical environment"> physical environment</a>, <a href="https://publications.waset.org/abstracts/search?q=healthcare" title=" healthcare"> healthcare</a> </p> <a href="https://publications.waset.org/abstracts/155220/the-impact-of-covid-19-health-measures-on-adults-with-multiple-chemical-sensitivity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/155220.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">86</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" 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Search results for: Rosalie Sears