Genetic engineering | Definition, Process, Uses, Examples, Techniques, & Facts

<!doctype html> <html lang="en" class="topic-desktop ui-ie7 ui-ie"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb#"> <meta charset="utf-8"> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <link rel="dns-prefetch" href="https://cdn.britannica.com/mendel-resources/3-133"> <link rel="preconnect" href="https://cdn.britannica.com/mendel-resources/3-133"> <link rel="preload" as="script" href="https://www.googletagservices.com/tag/js/gpt.js" /> <link rel="icon" href="/favicon.png" /> <meta name="description" content="Genetic engineering, the artificial manipulation, modification, and recombination of DNA or other nucleic acid molecules to modify an organism. The term is generally used to refer specifically to methods of recombinant DNA technology. Learn about the history, techniques, and applications of genetic engineering." /> <meta name="keywords" content="genetic engineering, encyclopedia, encyclopeadia, britannica, article" /> <link rel="canonical" href="https://www.britannica.com/science/genetic-engineering" /> <title>Genetic engineering | Definition, Process, Uses, Examples, Techniques, & Facts | Britannica</title>  <script> !function(){"use strict";function e(e){const t=e.match(/((?=([a-z0-9._!#$%+^&*()[\]<>-]+))\2@[a-z0-9._-]+\.[a-z0-9._-]+)/gi);return t?t[0]:""}function t(t){return e(a(t.toLowerCase()))}function a(e){return e.replace(/\s/g,"")}async function n(e){const t={sha256Hash:"",sha1Hash:""};if(!("msCrypto"in window)&&"https:"===location.protocol&&"crypto"in window&&"TextEncoder"in window){const a=(new TextEncoder).encode(e),[n,c]=await Promise.all([s("SHA-256",a),s("SHA-1",a)]);t.sha256Hash=n,t.sha1Hash=c}return t}async function s(e,t){const a=await crypto.subtle.digest(e,t);return Array.from(new Uint8Array(a)).map(e=>("00"+e.toString(16)).slice(-2)).join("")}function c(e){let t=!0;return Object.keys(e).forEach(a=>{0===e[a].length&&(t=!1)}),t}function i(e,t,a){e.splice(t,1);const n="?"+e.join("&")+a.hash;history.replaceState(null,"",n)}var o={checkEmail:e,validateEmail:t,trimInput:a,hashEmail:n,hasHashes:c,removeEmailAndReplaceHistory:i,detectEmails:async function(){const e=new URL(window.location.href),a=Array.from(e.searchParams.entries()).map(e=>`=`);let s,o;const r=["adt_eih","sh_kit"];if(a.forEach((e,t)=>{const a=decodeURIComponent(e),[n,c]=a.split("=");if("adt_ei"===n&&(s={value:c,index:t,emsrc:"url"}),r.includes(n)){o={value:c,index:t,emsrc:"sh_kit"===n?"urlhck":"urlh"}}}),s)t(s.value)&&n(s.value).then(e=>{if(c(e)){const t={value:e,created:Date.now()};localStorage.setItem("adt_ei",JSON.stringify(t)),localStorage.setItem("adt_emsrc",s.emsrc)}});else if(o){const e={value:{sha256Hash:o.value,sha1Hash:""},created:Date.now()};localStorage.setItem("adt_ei",JSON.stringify(e)),localStorage.setItem("adt_emsrc",o.emsrc)}s&&i(a,s.index,e),o&&i(a,o.index,e)},cb:"adthrive"};const{detectEmails:r,cb:l}=o;r()}(); </script> <script type="text/javascript" data-type="Init Mendel"> window.$UI = {}; window.Constants = {"LICENSE_URL": "/bps/license","DEFAULT_TEST_VERSION": "A","DEFAULT_STATE": "XX","QUIZ_URL": "/quiz","SPOTLIGHT_BROWSE_URL": "/stories/spotlight","CONTENT_TYPE_TEXT": "text/plain;charset=UTF-8","TOPIC_FACTS_DATA_URL": "/facts","QUIZ_BROWSE_IMAGE_QUIZZES": "images","TOPIC_MEDIA_PATH": "/images-videos","USER_PROFILE_URL": "/user","DEBUG_URL": "/debug","ONE_GOOD_FACT_URL": "/one-good-fact","ERROR_404_URL": "/error404","PROCON_CITED_IN_THE_NEWS_URL": "/procon/ProCon-in-the-News","PROCON_URL": "/procon","TOPIC_PAGE_CONTENT_AJAX_URL": "/topic-content/page","INFINITE_SCROLL_PREFIX_URL": "/scroll","TOPIC_TOP_QUESTION_BROWSE_URL": "/questions","CC_USD": "USD","domain": "britannica.com","PROCON_EDITOR_ID": "12941390","SURVEY_URL": "/survey","CATEGORY_BROWSE_URL": "/browse","STORY_BROWSE_URL": "/stories","COUNTRY_US": "US","OPEN_MEDIA_OVERLAY_PARAMETER": "/media","NEWSLETTER_SUBSCRIPTION_URL": "/newsletter-subscription","MAINTENANCE_ERROR_URL": "https://maintenance.eb.com","IMARS_EDITOR_ID": "12365882","PROFILE_EB_EDITOR_URL": "/editor","WEB_INF_RESOURCES_PATH": "WEB-INF/resources","AI_ABOUT_PAGE_URL": "/about-britannica-ai","TOPIC_ADDITIONAL_INFO_PATH": "/additional-info","SUDOKU_GAME_URL": "/games/sudoku","CC_INR": "INR","ARTICLE_PRINT_URL": "/print/article","FIRST_EDITION_URL": "/subscriber/firstedition","WW1_PORTAL_URL": "/discover/World-War-I","MENDEL_COOKIE": "__mendel","topicUrlClasses": "[topic, animal, art, biography, event, place, plant, science, sports, technology, procon, money]","DEMYSTIFIED_BROWSE_URL": "/stories/demystified","LIST_BROWSE_URL": "/list/browse","PROFILE_EXPERT_URL": "/contributor","ASSEMBLY_IMAGE_URL": "/image/assembly","DAY_IN_HISTORY_URL": "/on-this-day","DEFAULT_CURRENCY": "USD","CONTENT_TYPE_XML": "text/xml;charset=UTF-8","PORTAL_FINANCE_BROWSE_URL_PREFIX": "/money/browse","MONEY_IMARS_CATEGORY": "13000","AJAX_PREFIX_URL": "/ajax","TOPIC_BROWSE_URL": "/topic-browse","MARKETING_CONTENT": "/marketing-content","ENV_RUNTIME": "runtime","GALLERY_URL": "/gallery","topicUrlClassesList": "topic|animal|art|biography|event|place|plant|science|sports|technology|procon","CONTENT_TYPE_HTML": "text/html;charset=UTF-8","ENV_LOCAL": "override","MEDIA_OVERLAY_URL": "/media-overlay","CHATBOT_PAGE_URL": "/chatbot","NEWSLETTER_PAGE_URL": "/newsletters","ENV_DEV": "development","MEDIA_URL": "/media","TOPIC_TOP_QUESTION_URL": "/question","PORTAL_FINANCE_URL_PREFIX": "/money","PODCASTS_URL": "/podcasts","STAND_ALONE_VIDEO_URL": "/video","MORE_ON_THIS_DAY_URL": "/more-on-this-day","TOPIC_QUOTES_URL": "/quotes","SEARCH_PAGE_URL": "/search","PROCON_CLASS": "PROCON","KUSTOM_MENDEL_APPLICATION_ID": "1","TOPIC_CONTENT_AJAX_URL": "/topic-content/topic","ENV_BRANCH": "branch","ERROR_URL": "/error","MAIN_VERSION": "mainVersion","TOPIC_COLLECTION_URL": "/summary","LOGINBOX_URL": "/auth/loginbox","PROCON_DEBATE_TOPICS_URL": "/procon/Debate-Topics","ONE_GOOD_FACT_BROWSE_URL": "/one-good-fact/all-good-facts","QUIZ_BROWSE_URL": "/quiz/browse","BIO_BROWSE_URL": "/browse/biographies","LIST_URL": "/list","TIGHTROPE_QUIZ_URL": "/quiz/tightrope","ALPHA_BROWSE_URL": "/sitemap","CONTENT_TYPE_JSON": "application/json","DICTIONARY_URL": "/dictionary","COBRAND_IMAGE_URL": "/image/cobrand","PROCON_IN_THE_NEWS_URL": "/procon/pro-and-con-issues-in-the-news","PROCON_BROWSE_URL": "/procon","QUIZ_BROWSE_VOCAB_QUIZZES": "vocabulary-quizzes","SUBMISSION_URL": "/submission","EB_LOG_OUT": "/auth2/logout","ENV_PRODUCTION": "production","EXPLORE_PORTAL_URL": "/explore","TOPIC_AJAX_URL": "/ajax/topic","TOPIC_SUMMARY_BROWSE_URL": "/summaries","WTFACT_BROWSE_URL": "/stories/wtfact","VIDEO_CHANNEL_URL": "/videos","GALLERY_BROWSE_URL": "/gallery/browse","CACHE_URL": "/cache","PROCON_ABOUT_URL": "/procon/About-ProCon","COMPANION_BROWSE_URL": "/stories/companion","MEDIA_FOLDER": "/eb-media","SHOW_ALL_CONTRIBUTORS": "/additional-info#contributors","BRITANNICA_EDITORS_ID": "4419","ENV_CACHE_DISABLED": "mendelCache","CALCULATORS_BROWSE_URL": "/calculators","STORY_URL": "/story","DEFAULT_COUNTRY": "US","NAVBAR_URL": "/ajax/navbar","EB_LOGIN_URL": "/auth/eb-login","NEW_ARTICLES_URL": "/new-articles",}; window.CDN = "https://cdn.britannica.com"; window.CAM_SETTINGS_URL = "https://cam.britannica.com/settings"; window.CAM_LOGIN_URL = "https://cam.britannica.com/login"; window.CAM_SIGN_UP_URL = "https://cam.britannica.com/registration" window.Mendel = { "config" : { "domain": "britannica.com", "page": "Topic", "videoPlayerId": "UyMCoK2v", "sharedUrl": "https://www.britannica.com/science/genetic-engineering", "amuselabsUrl": "https://cdn3.amuselabs.com", "resourcesPrefixUrl": "https://cdn.britannica.com/mendel-resources/3-133/[url]?v=3.133.9", "date": 20250217, "userInfo": { "type": "ANONYMOUS" ,"currency": "AUUS" ,"country": "SG" ,"state": "XX" ,"timezone": "Asia/Singapore" ,"bcomId": "-1618434526888870797" ,"hasAds": true ,"testVersion": "D" ,"adsTestVersion": "D" ,"consumerId": "" ,"instId": "" ,"consumerUserName": "" ,"instUserName": "" ,"cognito": null }, "tvs":{ "r":[25,25,25,25], "a": [25,25,45,5]}, "isLoggedInAsUser": false, "isPhone": false, "isDesktop": true, "logoutUrl": "/auth2/logout", "selfServiceUrl": "https://myaccount.britannica.com", "cdnUrl": "https://cdn.britannica.com", "chatbotApi": "https://www.britannica.com/chat-api", "fetchOffset": 800, "mendelCookieName": "__mendel", "mendelCookie": {"surveyShown":false,"visitedTopicId":228897,"currentDate":20250217}, "autocompleteToSearchPage": false,"topicUrl": "https://www.britannica.com/science/genetic-engineering", "freeTopicReason": "PERMANENT_FREE_TOPIC", "topicId": 228897, "template": "DESKTOP", "type": "CORE", "hasToc": true, "chatbotApi": "https://www.britannica.com/chat-api", "showPreview": false, }, "GA": {"leg":"D","adLeg":"D","userType":"ANONYMOUS","pageType":"Topic","articleTemplateType":"PAGINATED","gisted":false,"pageNumber":1,"hasSummarizeButton":false,"hasAskButton":true} }; </script> <meta property="fb:app_id" content="1887621861548296"/ <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:site" content="@britannica" /> <meta name="twitter:image" content="https://cdn.britannica.com/73/187373-050-1564B18E/salmon-age-ability-genomes-questions-animals.jpg" /> <meta name="twitter:description" content="Genetic engineering, the artificial manipulation, modification, and recombination of DNA or other nucleic acid molecules to modify an organism. The term is generally used to refer specifically to methods of recombinant DNA technology. Learn about the history, techniques, and applications of genetic engineering."/> <meta property="og:type" content="ARTICLE"/> <meta property="og:title" content="Genetic engineering | Definition, Process, Uses, Examples, Techniques, & Facts | Britannica"/> <meta property="og:description" content="Genetic engineering, the artificial manipulation, modification, and recombination of DNA or other nucleic acid molecules to modify an organism. The term is generally used to refer specifically to methods of recombinant DNA technology. Learn about the history, techniques, and applications of genetic engineering."/> <meta property="og:site_name" content="Encyclopedia Britannica" /> <meta property="og:url" content="https://www.britannica.com/science/genetic-engineering"/> <meta property="og:image" content="https://cdn.britannica.com/73/187373-050-1564B18E/salmon-age-ability-genomes-questions-animals.jpg" /> <meta property="og:image:type" content="image/jpeg" /> <script type="text/javascript" data-type="init opengraph"> Mendel.openGraph = {"type":"ARTICLE","title":"Genetic engineering | Definition, Process, Uses, Examples, Techniques, & Facts","description":"Genetic engineering, the artificial manipulation, modification, and recombination of DNA or other nucleic acid molecules to modify an organism. The term is generally used to refer specifically to methods of recombinant DNA technology. Learn about the history, techniques, and applications of genetic engineering.","imageUrl":"https://cdn.britannica.com/73/187373-050-1564B18E/salmon-age-ability-genomes-questions-animals.jpg","imageType":"image/jpeg","pageUrl":"https://www.britannica.com/science/genetic-engineering"}</script> <link rel="preconnect" href="https://fonts.googleapis.com/"> <link rel="dns-prefetch" href="https://fonts.googleapis.com/" > <link rel="stylesheet" href="https://fonts.googleapis.com/icon?family=Material+Icons"> <link href="https://cdn.britannica.com/mendel-resources/3-133/dist/vendor-bundle.css?v=3.133.9" rel="stylesheet" /> <link href="https://cdn.britannica.com/mendel-resources/3-133/dist/mendel-css.css?v=3.133.9" rel="stylesheet" /> <link href="https://cdn.britannica.com/mendel-resources/3-133/dist/topic-page.css?v=3.133.9" rel="stylesheet" /> <script type="text/javascript"> if (self !== top) { top.location = self.location; } </script> <script src="https://cdn.britannica.com/mendel-resources/3-133/js/at.js?v=3.133.9" async ></script> <script> dataLayer = []; </script> <script type="text/javascript">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= '//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-5W6NC8'); </script> <meta name="last-modified" content="2025-02-15" /> <script type="application/ld+json"> {"headline":"Genetic engineering | Definition, Process, Uses, Examples, Techniques, & Facts","image":{"url":"https://cdn.britannica.com/73/187373-050-1564B18E/salmon-age-ability-genomes-questions-animals.jpg","@type":"ImageObject"},"author":[{"name":"The Editors of Encyclopaedia Britannica","url":"https://www.britannica.com/editor/The-Editors-of-Encyclopaedia-Britannica/4419","@type":"Person"}],"keywords":"genetic engineering","wordcount":1106,"url":"https://www.britannica.com/science/genetic-engineering","datePublished":"1998-07-20T00:00:00Z","dateModified":"2025-02-15T00:00:00Z","description":"Genetic engineering, the artificial manipulation, modification, and recombination of DNA or other nucleic acid molecules to modify an organism. The term is generally used to refer specifically to methods of recombinant DNA technology. Learn about the history, techniques, and applications of genetic engineering.","publisher":{"name":"Encyclopedia Britannica","@type":"Organization","logo":{"url":"https://corporate.britannica.com/wp-content/themes/eb-corporate/_img/logo.png","@type":"ImageObject"}},"@context":"https://schema.org","@type":"article"} </script> </head> <body data-leg="D" class="new-topic topic-desktop first-page-true user-ANONYMOUS user-ads md-desktop leg-d b-ie">  <script>Mendel.config.adProvider='cafemedia';</script> <script data-no-optimize="1" data-cfasync="false"> (function(w, d) { w.adthrive = w.adthrive || {}; w.adthrive.cmd = w. adthrive.cmd || []; w.adthrive.plugin = 'adthrive-ads-manual'; w.adthrive.host = 'ads.adthrive.com';var s = d.createElement('script'); s.async = true; s.referrerpolicy='no-referrer-when-downgrade'; s.src = 'https://' + w.adthrive.host + '/sites/61575e5c934c481d714b3ca9/ads.min.js?referrer=' + w.encodeURIComponent(w.location.href) + '&cb=' + (Math.floor(Math.random() * 100) + 1); var n = d.getElementsByTagName('script')[0]; n.parentNode.insertBefore(s, n); })(window, document); </script> <div class="ie-warning d-flex align-items-center align-self-center justify-content-center site-alert bg-orange"> <div> You are using an <strong>outdated</strong> browser. Please <a class="text-white text-underscore" href="https://browsehappy.com/">upgrade your browser</a> to improve your experience and security. </div> </div> <script id="json-navbar-info" type="application/json"> {"topSectionLinks":[{"title":"Ask the Chatbot","url":"/chatbot","navbarId":"CHATBOT"},{"title":"Games & Quizzes","url":"/quiz/browse","navbarId":"QUIZZES"},{"title":"History & Society","url":"/History-Society","navbarId":"HISTORY"},{"title":"Science & Tech","url":"/Science-Tech","selected":true,"navbarId":"SCIENCE"},{"title":"Biographies","url":"/Biographies","navbarId":"BIOS"},{"title":"Animals & Nature","url":"/Animals-Nature","navbarId":"ANIMALS"},{"title":"Geography & Travel","url":"/Geography-Travel","navbarId":"GEOGRAPHY"},{"title":"Arts & Culture","url":"/Arts-Culture","navbarId":"ART"},{"title":"ProCon","url":"/procon","navbarId":"PROCON"},{"title":"Money","url":"/money","navbarId":"MONEY"},{"title":"Videos","url":"/videos","navbarId":"VIDEOS"}],"selectedSuperCategory":{"id":6,"title":"Science & Tech","url":"Science-Tech","description":"Explore science and technology; astronomy; biology; chemistry; earth science; mathematics; physics; technology, agriculture, cars, computers, engineering, industry, inventions, communication","keywords":"astronomy; biology; chemistry; earth science; mathematics; physics; technology, agriculture, cars, computers, engineering, industry, inventions, communication","classId":"SCIENCE","sortOrder":2},"selectedNavbarLink":{"title":"Science & Tech","url":"/Science-Tech","selected":true,"navbarId":"SCIENCE"}} </script> <script id="json-hamburger-menu" type="application/json"> {"britannicaMenu1":[{"title":"Home","url":"/"},{"title":"History & Society","url":"/History-Society"},{"title":"Science & Tech","url":"/Science-Tech"},{"title":"Biographies","url":"/Biographies"},{"title":"Animals & Nature","url":"/Animals-Nature"},{"title":"Geography & Travel","url":"/Geography-Travel"},{"title":"Arts & Culture","url":"/Arts-Culture"},{"title":"ProCon","url":"/procon"},{"title":"Money","url":"/money"}],"britannicaMenu2":[{"title":"Games & Quizzes","url":"/quiz/browse"},{"title":"Videos","url":"/videos"},{"title":"On This Day","url":"/on-this-day"},{"title":"One Good Fact","url":"/one-good-fact"},{"title":"Dictionary","url":"/dictionary"},{"title":"New Articles","url":"/new-articles"}],"browseByCategory":[{"title":{"id":5,"title":"History & Society","url":"/History-Society"},"links":[{"title":"Lifestyles & Social Issues","url":"/browse/Lifestyles-Social-Issues"},{"title":"Philosophy & Religion","url":"/browse/Philosophy-Religion"},{"title":"Politics, Law & Government","url":"/browse/Politics-Law-Government"},{"title":"World History","url":"/browse/World-History"}]},{"title":{"id":6,"title":"Science & Tech","url":"/Science-Tech"},"links":[{"title":"Health & Medicine","url":"/browse/Health-Medicine"},{"title":"Science","url":"/browse/Science"},{"title":"Technology","url":"/browse/Technology"}]},{"title":{"id":3,"title":"Biographies","url":"/Biographies"},"links":[{"title":"Browse Biographies","url":"/browse/biographies"}]},{"title":{"id":1,"title":"Animals & Nature","url":"/Animals-Nature"},"links":[{"title":"Birds, Reptiles & Other Vertebrates","url":"/browse/Birds-Reptiles-Vertebrates"},{"title":"Bugs, Mollusks & Other Invertebrates","url":"/browse/Bugs-Mollusks-Invertebrates"},{"title":"Environment","url":"/browse/Environment"},{"title":"Fossils & Geologic Time","url":"/browse/Fossil-Geologic-Time"},{"title":"Mammals","url":"/browse/Mammals"},{"title":"Plants","url":"/browse/Plants"}]},{"title":{"id":4,"title":"Geography & Travel","url":"/Geography-Travel"},"links":[{"title":"Geography & Travel","url":"/browse/Geography-Travel"}]},{"title":{"id":2,"title":"Arts & Culture","url":"/Arts-Culture"},"links":[{"title":"Entertainment & Pop Culture","url":"/browse/Entertainment-Pop-Culture"},{"title":"Literature","url":"/browse/Literature"},{"title":"Sports & Recreation","url":"/browse/Sports-Recreation"},{"title":"Visual Arts","url":"/browse/Visual-Arts"}]}],"browseByFeature":[{"title":"Companions","url":"/stories/companion"},{"title":"Demystified","url":"/stories/demystified"},{"title":"Image Galleries","url":"/gallery/browse"},{"title":"Lists","url":"/list/browse"},{"title":"Podcasts","url":"/podcasts"},{"title":"Spotlight","url":"/stories/spotlight"},{"title":"Summaries","url":"/summary"},{"title":"The Forum","url":"/stories/the-forum"},{"title":"Top Questions","url":"/question"},{"title":"#WTFact","url":"/stories/wtfact"}],"moreFromBritannica":[{"title":"Britannica Kids","url":"https://kids.britannica.com/","newTab":true}],"menuType":"DEFAULT"} </script> <header id="header" class="bg-navy-dark"> <div class="global-nav-top-bar"> <div class="grid gx-0 h-100 justify-content-between align-items-center container-lg mx-auto p-0 position-relative"> <div class="d-flex align-items-center"> <button class="d-flex align-items-center justify-self-start js-toggle js-toggle-hamburger btn btn-link link-white btn-sm rounded-0 p-10"> <div class="hamburger-tooltip"> <em class="material-icons d-inline-block font-24" id="nav-toggle" data-icon="menu"></em> </div> <em class="material-icons d-inline-block font-24 global-nav-search-icon" id="nav-search-icon" data-icon="search" ></em> </button> <a href="/" class="d-flex align-items-center justify-content-center ml-10"> <img loading="lazy" src="https://cdn.britannica.com/mendel/eb-logo/MendelNewThistleLogo.png" alt="Encyclopedia Britannica" class="global-nav-logo global-nav-logo-left" /> </a> <div class="global-nav-top-search-bar global-nav-top-search-container global-nav-search-container" id="global-nav-top-search-bar"> <form method="get" action="/search" id="global-nav-search" class="md-search-form m-0 global-nav-search-bar-small"> <div class="search-box position-relative col-100"> <label class="sr-only" for="global-nav-search-query">Search Britannica</label> <input name="query" id="global-nav-search-query" placeholder="Search Britannica..." class="form-control form-control-lg rounded-lg font-16 search-query pl-20 pr-70 shadow-sm" maxlength="200" autocomplete="off" aria-label="Search Britannica" /> <button class="search-reset-btn btn btn-link px-10 position-absolute top-0 h-100 d-none" type="reset"> <em class="material-icons" data-icon="close"></em> </button> <button class="search-submit btn btn-link text-blue px-10 position-absolute top-0 right-0 h-100" type="submit" disabled> <span class="sr-only">Click here to search</span> <em class="material-icons search-icon" data-icon="search"></em> </button> </div> </form> </div> </div> <a href="/" class="d-flex align-items-center justify-content-center"> <img loading="lazy" src="https://cdn.britannica.com/mendel/eb-logo/MendelNewThistleLogo.png" alt="Encyclopedia Britannica" class="global-nav-center global-nav-logo non-homepage-logo" /> </a> <form method="get" action="/search" id="global-nav-search" class="md-search-form m-0 global-nav-search-bar-small global-nav-center search global-nav-center-search-container"> <div class="search-box position-relative col-100"> <label class="sr-only" for="global-nav-search-query">Search Britannica</label> <input name="query" id="global-nav-search-query" placeholder="Search Britannica..." class="form-control form-control-lg rounded-lg font-16 search-query pl-20 pr-70 shadow-sm" maxlength="200" autocomplete="off" aria-label="Search Britannica" /> <button class="search-reset-btn btn btn-link px-10 position-absolute top-0 h-100 d-none" type="reset"> <em class="material-icons" data-icon="close"></em> </button> <button class="search-submit btn btn-link text-blue px-10 position-absolute top-0 right-0 h-100" type="submit" disabled> <span class="sr-only">Click here to search</span> <em class="material-icons search-icon" data-icon="search"></em> </button> </div> </form> <div class="col-35 col-sm-auto text-right order-3 mr-lg-15 align-items-center d-flex justify-content-end"> <div class="d-none d-md-inline-block"> <SPAN class="marketing-HEADER_SUBSCRIPTION_DESKTOP2 marketing-content" data-marketing-id="HEADER_SUBSCRIPTION_DESKTOP2"><a href="https://premium.britannica.com/premium-membership/?utm_source=premium&utm_medium=global-nav&utm_campaign=evergreen-cap" class="subscribe-link btn btn-sm btn-orange py-5 mr-10" target="_blank" rel="noopener"> SUBSCRIBE </a></SPAN></div> <div class="d-inline-block d-md-none mr-5 mr-sm-10"> <SPAN class="marketing-HEADER_SUBSCRIPTION_MOBILE marketing-content" data-marketing-id="HEADER_SUBSCRIPTION_MOBILE"><a href="https://premium.britannica.com/premium-membership/?utm_source=premium&utm_medium=global-nav-mobile&utm_campaign=evergreen" class="subscribe-link btn btn-xs btn-orange p-5" target="_blank" rel="noopener"> SUBSCRIBE </a></SPAN></div> <button class="js-toggle-user-dropdown js-toggle btn btn-sm btn-link link-white rounded-0 px-md-15 pl-5 pr-5"> <span class="d-none d-md-inline-block mr-5">Login</span> <em class="material-icons d-inline-block d-md-none font-16 font-sm-20" data-icon="account_circle"></em> <div class="d-none dropdown-menu-subscription-link">https://premium.britannica.com/premium-membership/?utm_source=premium&utm_medium=nav-login-box&utm_campaign=evergreen</div> <em class="material-icons inactive-icon d-inline-block font-18" data-icon="keyboard_arrow_down"></em> <em class="material-icons active-icon d-inline-block font-18" data-icon="keyboard_arrow_up"></em> </button> </div> </div> </div> <div class="d-none hamburger-menu-subscription-link"><DIV class="marketing-HAMBURGER_MENU_CTA marketing-content" data-marketing-id="HAMBURGER_MENU_CTA"><a href="https://premium.britannica.com/premium-membership/?utm_source=premium&utm_medium=hamburger-menu&utm_campaign=evergreen" class="subscribe-link btn btn-sm btn-orange py-5" target="_blank"> SUBSCRIBE </a></DIV></div> <div id="global-nav-react"> <div class="d-none"> <ul> <li><a href="/">Home</a></li> <li><a href="/History-Society">History & Society</a></li> <li><a href="/Science-Tech">Science & Tech</a></li> <li><a href="/Biographies">Biographies</a></li> <li><a href="/Animals-Nature">Animals & Nature</a></li> <li><a href="/Geography-Travel">Geography & Travel</a></li> <li><a href="/Arts-Culture">Arts & Culture</a></li> <li><a href="/procon">ProCon</a></li> <li><a href="/money">Money</a></li> </ul> <ul> <li><a href="/quiz/browse">Games & Quizzes</a></li> <li><a href="/videos">Videos</a></li> <li><a href="/on-this-day">On This Day</a></li> <li><a href="/one-good-fact">One Good Fact</a></li> <li><a href="/dictionary">Dictionary</a></li> <li><a href="/new-articles">New Articles</a></li> </ul> <a href="/History-Society">History & Society</a> <ul> <li><a href="/browse/Lifestyles-Social-Issues">Lifestyles & Social Issues</a></li> <li><a href="/browse/Philosophy-Religion">Philosophy & Religion</a></li> <li><a href="/browse/Politics-Law-Government">Politics, Law & Government</a></li> <li><a href="/browse/World-History">World History</a></li> </ul> <a href="/Science-Tech">Science & Tech</a> <ul> <li><a href="/browse/Health-Medicine">Health & Medicine</a></li> <li><a href="/browse/Science">Science</a></li> <li><a href="/browse/Technology">Technology</a></li> </ul> <a href="/Biographies">Biographies</a> <ul> <li><a href="/browse/biographies">Browse Biographies</a></li> </ul> <a href="/Animals-Nature">Animals & Nature</a> <ul> <li><a href="/browse/Birds-Reptiles-Vertebrates">Birds, Reptiles & Other Vertebrates</a></li> <li><a href="/browse/Bugs-Mollusks-Invertebrates">Bugs, Mollusks & Other Invertebrates</a></li> <li><a href="/browse/Environment">Environment</a></li> <li><a href="/browse/Fossil-Geologic-Time">Fossils & Geologic Time</a></li> <li><a href="/browse/Mammals">Mammals</a></li> <li><a href="/browse/Plants">Plants</a></li> </ul> <a href="/Geography-Travel">Geography & Travel</a> <ul> <li><a href="/browse/Geography-Travel">Geography & Travel</a></li> </ul> <a href="/Arts-Culture">Arts & Culture</a> <ul> <li><a href="/browse/Entertainment-Pop-Culture">Entertainment & Pop Culture</a></li> <li><a href="/browse/Literature">Literature</a></li> <li><a href="/browse/Sports-Recreation">Sports & Recreation</a></li> <li><a href="/browse/Visual-Arts">Visual Arts</a></li> </ul> <ul> <li><a href="/stories/companion">Companions</a></li> <li><a href="/stories/demystified">Demystified</a></li> <li><a href="/gallery/browse">Image Galleries</a></li> <li><a href="/list/browse">Lists</a></li> <li><a href="/podcasts">Podcasts</a></li> <li><a href="/stories/spotlight">Spotlight</a></li> <li><a href="/summary">Summaries</a></li> <li><a href="/stories/the-forum">The Forum</a></li> <li><a href="/question">Top Questions</a></li> <li><a href="/stories/wtfact">#WTFact</a></li> </ul> <ul> <li><a href="https://kids.britannica.com/">Britannica Kids</a></li> </ul> </div> </div> </header> <div class="bg-navy-dark"> <div class="container-lg p-0 d-flex justify-content-center global-nav-categories-bar overflow-hidden"> <div class="slider js-slider position-relative d-inline-flex align-items-center mw-100 global-nav-slider category-snap-slider"> <div class="slider-container js-slider-container overflow-hidden d-flex font-14 overflow-hidden text-nowrap mx-5"> <a class="nav-bar-category mx-5 category-link-CHATBOT " href="/chatbot">Ask the Chatbot</a> <a class="nav-bar-category mx-5 category-link-QUIZZES " href="/quiz/browse">Games & Quizzes</a> <a class="nav-bar-category mx-5 category-link-HISTORY " href="/History-Society">History & Society</a> <a class="nav-bar-category mx-5 category-link-SCIENCE selected selected" href="/Science-Tech">Science & Tech</a> <a class="nav-bar-category mx-5 category-link-BIOS " href="/Biographies">Biographies</a> <a class="nav-bar-category mx-5 category-link-ANIMALS " href="/Animals-Nature">Animals & Nature</a> <a class="nav-bar-category mx-5 category-link-GEOGRAPHY " href="/Geography-Travel">Geography & Travel</a> <a class="nav-bar-category mx-5 category-link-ART " href="/Arts-Culture">Arts & Culture</a> <a class="nav-bar-category mx-5 category-link-PROCON " href="/procon">ProCon</a> <a class="nav-bar-category mx-5 category-link-MONEY " href="/money">Money</a> <a class="nav-bar-category mx-5 category-link-VIDEOS " href="/videos">Videos</a> </div> <button disabled class="prev-button js-prev-button position-absolute btn btn-circle shadow btn-blue " aria-label="Previous"> <span class="material-icons md-24" data-icon="keyboard_arrow_left"></span> </button> <button disabled class="next-button js-next-button position-absolute btn btn-circle shadow btn-blue " aria-label="Next"> <span class="material-icons md-24" data-icon="keyboard_arrow_right"></span> </button> </div> </div> </div> <main> <div class="md-page-wrapper"> <div id="content" class="md-content"> <div class="md-article-container template-desktop infinite-pagination"> <div class="infinite-scroll-container article last"> <script> Object.assign( window.Mendel.config, { "infiniteScrollList": [{"p":2,"t":228897},{"p":2,"t":1998073},{"p":1,"t":681974},{"p":2,"t":897705},{"p":2,"t":1692043},{"p":2,"t":195069},{"p":6,"t":228936},{"p":1,"t":422006},{"p":2,"t":1081570},{"p":4,"t":65851}], "sequence": 1, "topics": {} }); </script> <article class="article-content container-lg qa-content px-0 pt-0 pb-40 py-lg-20 content md-expanded" data-topic-id="228897"> <div class="grid gx-0"> <div class="col-auto"> <div class="topic-left-rail md-article-drawer position-relative d-flex border-right-sm border-left-sm open"> <div class="drawer d-flex flex-column open"> <div class="left-rail-section-content"> <div class="topic-left-rail-header text-truncate bg-gray-50 position-relative text-right d-flex align-items-center"> <div class="tlr-title px-20 py-15 text-left"> <em class="material-icons text-gray-400 d-lg-none" data-icon="toc"></em> <a class="font-serif font-weight-bold text-black link-blue" href="https://www.britannica.com/science/genetic-engineering">genetic engineering</a> </div> <button aria-label="Close" class="js-sections-close-button btn-link btn-sm btn d-lg-none position-absolute top-0 p-10 right-0" > <em class="material-icons font-26" data-icon="close"></em> </button> </div> <div class="section-content pl-10 pr-20 pl-sm-50 pr-sm-60 pl-lg-5 pr-lg-10 pt-10 pt-lg-0 bg-gray-50 clear-catfish-ad"> <div class="toc mb-20"> <div class="font-serif font-14 font-weight-bold mx-15 mb-15 mt-20"> Table of Contents </div> <ul class="list-unstyled my-0" data-level="h1"><li data-target="#ref1"><div class="pl-25"><a class="link-gray-900 w-100" href="/science/genetic-engineering">Introduction</a></div><div class="ml-40 toc-drawer sub-toc-drawer"></div></li><li data-target="#ref337079"><div class="d-flex align-items-center"><div class="ml-25"></div><a class="w-100 link-gray-900" href="/science/genetic-engineering#ref337079">Historical developments</a></div><div class="ml-40 toc-drawer sub-toc-drawer"></div></li><li data-target="#ref337080"><div class="d-flex align-items-center"><div class="ml-25"></div><a class="w-100 link-gray-900" href="/science/genetic-engineering/Process-and-techniques">Process and techniques</a></div><div class="ml-40 toc-drawer sub-toc-drawer"></div></li><li data-target="#ref337081"><div class="d-flex align-items-center"><div class="ml-25"></div><a class="w-100 link-gray-900" href="/science/genetic-engineering/Process-and-techniques#ref337081">Applications</a></div><div class="ml-40 toc-drawer sub-toc-drawer"></div></li><li data-target="#ref337082"><div class="d-flex align-items-center"><div class="ml-25"></div><a class="w-100 link-gray-900" href="/science/genetic-engineering/Process-and-techniques#ref337082">Controversy and ethical issues</a></div><div class="ml-40 toc-drawer sub-toc-drawer"></div></li></ul> <a class="toc-extra-link link-gray-900" href="https://www.britannica.com/science/genetic-engineering/additional-info">References & Edit History</a> <a class="toc-extra-link link-gray-900" href="/facts/genetic-engineering">Related Topics</a> </div> <div class="tlr-media-slider pb-10 mb-30"> <a class="section-header link-gray-900 font-serif font-14 font-weight-bold mb-10 mx-10" href="https://www.britannica.com/science/genetic-engineering/images-videos">Images & Videos</a> <div class="slider js-slider position-relative d-inline-flex align-items-center mw-100 "> <div class="slider-container js-slider-container overflow-hidden d-flex overflow-hidden text-nowrap ml-15"> <a href="https://cdn.britannica.com/73/187373-050-1564B18E/salmon-age-ability-genomes-questions-animals.jpg" data-href="/media/1/228897/204864" class="media-overlay-link d-inline-block mr-5"> <img loading="lazy" src="https://cdn.britannica.com/73/187373-004-9E9A7E7B/salmon-age-ability-genomes-questions-animals.jpg" alt="genetically engineered salmon" height="50" /> </a> <a href="/video/Genetically-Modified-Humans-CRISPR-Cas-9-Explained/280930" data-href="/media/1/228897/280930" class="media-overlay-link d-inline-block mr-5"> <div class="position-relative --aspect-ratio: 16/9"> <img loading="lazy" src="https://cdn.britannica.com/89/240889-138-BE17294D/Genetically-Modified-Humans-CRISPR-Cas-9-Explained.jpg?w=400&h=225&c=crop" alt="genetically modified humans" class="col-100" /> <div class="btn btn-sm btn-white btn-circle position-absolute shadow" style="top: 50%; left:50%; transform: translate(-50%, -50%)"> <em class="material-icons font-14" data-icon="play_arrow" > </em> </div> </div> </a> <a href="https://cdn.britannica.com/61/131361-050-1A1D205E/corn.jpg" data-href="/media/1/228897/128155" class="media-overlay-link d-inline-block mr-5"> <img loading="lazy" src="https://cdn.britannica.com/61/131361-004-07890150/corn.jpg" alt="Genetically engineered corn (maize)" height="50" /> </a> <a href="https://cdn.britannica.com/41/246541-050-8D5BA567/Golden-rice-GMO-Vitamin-A.jpg" data-href="/media/1/228897/292785" class="media-overlay-link d-inline-block mr-5"> <img loading="lazy" src="https://cdn.britannica.com/41/246541-004-B3F359D3/Golden-rice-GMO-Vitamin-A.jpg" alt="golden rice" height="50" /> </a> <a href="https://cdn.britannica.com/87/22487-050-739115AC/DNA-fragments-genomics-research-cells-vector-replication.jpg" data-href="/media/1/228897/17930" class="media-overlay-link d-inline-block mr-5"> <img loading="lazy" src="https://cdn.britannica.com/87/22487-004-16BC016E/DNA-fragments-genomics-research-cells-vector-replication.jpg" alt="Recombinant DNA" height="50" /> </a> <a href="/video/overview-genetic-engineering-microbes/206327" data-href="/media/1/228897/206327" class="media-overlay-link d-inline-block mr-5"> <div class="position-relative --aspect-ratio: 16/9"> <img loading="lazy" src="https://cdn.britannica.com/72/186472-138-3C616DD9/overview-genetic-engineering-microbes.jpg?w=400&h=225&c=crop" alt="Learn about genetic engineering and how it is applied to microbes to genetically modify them for use in medicines, food, and fuel" class="col-100" /> <div class="btn btn-sm btn-white btn-circle position-absolute shadow" style="top: 50%; left:50%; transform: translate(-50%, -50%)"> <em class="material-icons font-14" data-icon="play_arrow" > </em> </div> </div> </a> </div> <button disabled class="prev-button js-prev-button position-absolute btn btn-circle shadow btn-blue " aria-label="Previous"> <span class="material-icons md-24" data-icon="keyboard_arrow_left"></span> </button> <button disabled class="next-button js-next-button position-absolute btn btn-circle shadow btn-blue " aria-label="Next"> <span class="material-icons md-24" data-icon="keyboard_arrow_right"></span> </button> </div> </div> <div class="mb-30 tlr-student-links"> <div class="text-gray-900 p-5 font-serif font-14 font-weight-bold mx-10 mb-10"> For Students </div> <div class="imagelink-with-image-on-the-side card card-horizontal tlr-img-with-side-link ml-15 link-gray-900 mb-10" > <div class="position-relative card-media" style="flex: 0;"> <a class="ilf-image position-relative" href="/summary/genetic-engineering"> <img loading="lazy" src="https://cdn.britannica.com/mendel-resources/3-133/images/shared/default3.png?v=3.133.9" class="default " height="200" width="200"/> </a> </div> <div class="card-body ilf-content"> <a class="font-weight-semi-bold d-block mb-5 font-16 ilf-title" href="/summary/genetic-engineering" >genetic engineering summary</a> </div> </div> </div> <div class="mb-30 tlr-related-questions"> <div class="text-gray-900 p-5 pb-0 font-serif font-14 font-weight-bold mx-10 mb-15"> Related Questions </div> <ul> <li class="link-gray-900 mb-15"><a class="" href="/question/Are-genetically-modified-organisms-safe-for-the-environment">Are genetically modified organisms safe for the environment?</a> </li> <li class="link-gray-900 mb-15"><a class="" href="/question/Should-genetically-modified-crops-be-grown">Should genetically modified crops be grown?</a> </li> <li class="link-gray-900 mb-15"><a class="" href="/question/What-is-recombinant-DNA-technology">What is recombinant DNA technology? </a> </li> <li class="link-gray-900 mb-15"><a class="" href="/question/When-was-recombinant-DNA-technology-invented">When was recombinant DNA technology invented? </a> </li> <li class="link-gray-900 mb-15"><a class="" href="/question/How-is-recombinant-DNA-technology-useful">How is recombinant DNA technology useful? </a> </li> </ul> </div> <div class="mb-30 tlr-read-next"> <div class="text-gray-900 p-5 font-serif font-14 font-weight-bold mx-10 mb-10"> Read Next </div> <div class="imagelink-with-image-on-the-side card card-horizontal tlr-img-with-side-link ml-15 link-gray-900 mb-10" > <div class="position-relative card-media" style="flex: 0;"> <a class="ilf-image position-relative" href="/story/pro-and-con-gmos"> <img loading="lazy" src="https://cdn.britannica.com/33/75933-131-0C63E178/Rows-corn-field-Nebraska.jpg?w=200&h=200&c=crop" alt="Rows of tassled corn in a Nebraska field. (agriculture)" width="200" height="200" /> </a> </div> <div class="card-body ilf-content"> <a class="font-weight-semi-bold d-block mb-5 font-16 ilf-title" href="/story/pro-and-con-gmos" >Pro and Con: GMOs</a> </div> </div> <div class="imagelink-with-image-on-the-side card card-horizontal tlr-img-with-side-link ml-15 link-gray-900 mb-10" > <div class="position-relative card-media" style="flex: 0;"> <a class="ilf-image position-relative" href="/story/history-of-technology-timeline"> <img loading="lazy" src="https://cdn.britannica.com/84/203584-131-357FBE7D/speed-internet-technology-background.jpg?w=200&h=200&c=crop" alt="Abstract vector hi speed internet technology background" width="200" height="200" /> </a> </div> <div class="card-body ilf-content"> <a class="font-weight-semi-bold d-block mb-5 font-16 ilf-title" href="/story/history-of-technology-timeline" >History of Technology Timeline</a> </div> </div> <div class="imagelink-with-image-on-the-side card card-horizontal tlr-img-with-side-link ml-15 link-gray-900 mb-10" > <div class="position-relative card-media" style="flex: 0;"> <a class="ilf-image position-relative" href="/story/do-gm-foods-affect-the-body-differently"> <img loading="lazy" src="https://cdn.britannica.com/61/131361-131-59067FDF/corn.jpg?w=200&h=200&c=crop" alt="Genetically modified corn field. Genetically Modified Organism (GMO), transgenic corn, maize, agriculture, biological." width="200" height="200" /> </a> </div> <div class="card-body ilf-content"> <a class="font-weight-semi-bold d-block mb-5 font-16 ilf-title" href="/story/do-gm-foods-affect-the-body-differently" >Do GM Foods Affect the Body Differently?</a> </div> </div> <div class="imagelink-with-image-on-the-side card card-horizontal tlr-img-with-side-link ml-15 link-gray-900 mb-10" > <div class="position-relative card-media" style="flex: 0;"> <a class="ilf-image position-relative" href="/story/when-were-the-first-gmos-developed"> <img loading="lazy" src="https://cdn.britannica.com/17/231317-131-B0493E0E/Checking-petri-dish-genetically-modified-organisms-GMO-in-laboratory-setting.jpg?w=200&h=200&c=crop" alt="Checking a petri dish with genetically modified organisms (GMOs) in a experimental laboratory setting." width="200" height="200" /> </a> </div> <div class="card-body ilf-content"> <a class="font-weight-semi-bold d-block mb-5 font-16 ilf-title" href="/story/when-were-the-first-gmos-developed" >When Were the First GMOs Developed?</a> </div> </div> <div class="imagelink-with-image-on-the-side card card-horizontal tlr-img-with-side-link ml-15 link-gray-900 mb-10" > <div class="position-relative card-media" style="flex: 0;"> <a class="ilf-image position-relative" href="/list/6-questions-about-dna-answered"> <img loading="lazy" src="https://cdn.britannica.com/28/190928-131-CE088DB5/DNA-helix-concept-evolution-medicine-science.jpg?w=200&h=200&c=crop" alt="DNA helix in a futuristic concept of the evolution of science and medicine." width="200" height="200" /> </a> </div> <div class="card-body ilf-content"> <a class="font-weight-semi-bold d-block mb-5 font-16 ilf-title" href="/list/6-questions-about-dna-answered" >6 Questions About DNA Answered</a> </div> </div> </div> <div class="mb-30 tlr-discover"> <div class="text-gray-900 p-5 font-serif font-14 font-weight-bold mx-10 mb-10"> Discover </div> <div class="imagelink-with-image-on-the-side card card-horizontal tlr-img-with-side-link ml-15 link-gray-900 mb-10" > <div class="position-relative card-media" style="flex: 0;"> <a class="ilf-image position-relative" href="/story/how-many-countries-are-there-in-the-world"> <img loading="lazy" src="https://cdn.britannica.com/27/238527-131-D73B3F08/flagpoles-world-countries.jpg?w=200&h=200&c=crop" alt="Flags of the countries of the world (flagpoles)." width="200" height="200" /> </a> </div> <div class="card-body ilf-content"> <a class="font-weight-semi-bold d-block mb-5 font-16 ilf-title" href="/story/how-many-countries-are-there-in-the-world" >How Many Countries Are There in the World?</a> </div> </div> <div class="imagelink-with-image-on-the-side card card-horizontal tlr-img-with-side-link ml-15 link-gray-900 mb-10" > <div class="position-relative card-media" style="flex: 0;"> <a class="ilf-image position-relative" href="/list/7-nobel-prize-scandals"> <img loading="lazy" src="https://cdn.britannica.com/30/186230-131-03A4CF81/medal-winner-Nobel-Prize-Johannes-Diderik-Van.jpg?w=200&h=200&c=crop" alt="Commemorative medal of Nobel Prize winner, Johannes Diderik Van Der Waals" width="200" height="200" /> </a> </div> <div class="card-body ilf-content"> <a class="font-weight-semi-bold d-block mb-5 font-16 ilf-title" href="/list/7-nobel-prize-scandals" >7 Nobel Prize Scandals</a> </div> </div> <div class="imagelink-with-image-on-the-side card card-horizontal tlr-img-with-side-link ml-15 link-gray-900 mb-10" > <div class="position-relative card-media" style="flex: 0;"> <a class="ilf-image position-relative" href="/story/the-lost-colony-of-roanoke"> <img loading="lazy" src="https://cdn.britannica.com/39/191439-131-59FE0A72/John-White-word-tree-CROATOAN-Roanoke-Island-1590.jpg?w=200&h=200&c=crop" alt="The Lost Colony of Roanoke, North Carolina, where 115 people mysteriously disappeared c. 1590. John White discovers the word Croatoan carved onto a tree upon his return to the deserted Roanoke Colony in 1590" width="200" height="200" /> </a> </div> <div class="card-body ilf-content"> <a class="font-weight-semi-bold d-block mb-5 font-16 ilf-title" href="/story/the-lost-colony-of-roanoke" >The Lost Colony of Roanoke</a> </div> </div> <div class="imagelink-with-image-on-the-side card card-horizontal tlr-img-with-side-link ml-15 link-gray-900 mb-10" > <div class="position-relative card-media" style="flex: 0;"> <a class="ilf-image position-relative" href="/story/which-waters-do-you-pass-through-when-you-sail-the-seven-seas"> <img loading="lazy" src="https://cdn.britannica.com/97/196697-131-0155C802/Sailboat-landscape.jpg?w=200&h=200&c=crop" alt="Sailboat against a beautiful landscape" width="200" height="200" /> </a> </div> <div class="card-body ilf-content"> <a class="font-weight-semi-bold d-block mb-5 font-16 ilf-title" href="/story/which-waters-do-you-pass-through-when-you-sail-the-seven-seas" >Which Waters Do You Pass Through When You “Sail the Seven Seas”?</a> </div> </div> <div class="imagelink-with-image-on-the-side card card-horizontal tlr-img-with-side-link ml-15 link-gray-900 mb-10" > <div class="position-relative card-media" style="flex: 0;"> <a class="ilf-image position-relative" href="/story/is-spontaneous-human-combustion-real"> <img loading="lazy" src="https://cdn.britannica.com/07/195407-131-BF6F47C2/Illustration-Spontaneous-human-combustion.jpg?w=200&h=200&c=crop" alt="Illustration for Demystified "Spontaneous human combustion"." width="200" height="200" /> </a> </div> <div class="card-body ilf-content"> <a class="font-weight-semi-bold d-block mb-5 font-16 ilf-title" href="/story/is-spontaneous-human-combustion-real" >Is Spontaneous Human Combustion Real?</a> </div> </div> <div class="imagelink-with-image-on-the-side card card-horizontal tlr-img-with-side-link ml-15 link-gray-900 mb-10" > <div class="position-relative card-media" style="flex: 0;"> <a class="ilf-image position-relative" href="/story/nikola-teslas-weird-obsession-with-pigeons"> <img loading="lazy" src="https://cdn.britannica.com/13/173513-131-C6E1BD52/mourning-dove-North-America.jpg?w=200&h=200&c=crop" alt="bird. mourning dove. pigeon and dove. Mourning Dove (Zenaida macroura) family Columbidae." width="200" height="200" /> </a> </div> <div class="card-body ilf-content"> <a class="font-weight-semi-bold d-block mb-5 font-16 ilf-title" href="/story/nikola-teslas-weird-obsession-with-pigeons" >Nikola Tesla's Weird Obsession with Pigeons</a> </div> </div> <div class="imagelink-with-image-on-the-side card card-horizontal tlr-img-with-side-link ml-15 link-gray-900 mb-10" > <div class="position-relative card-media" style="flex: 0;"> <a class="ilf-image position-relative" href="/list/new-seven-wonders-of-the-world"> <img loading="lazy" src="https://cdn.britannica.com/36/162636-131-E4AA93A0/Colosseum-Rome-Italy.jpg?w=200&h=200&c=crop" alt="The Colosseum, Rome, Italy. Giant amphitheatre built in Rome under the Flavian emperors. (ancient architecture; architectural ruins)" width="200" height="200" /> </a> </div> <div class="card-body ilf-content"> <a class="font-weight-semi-bold d-block mb-5 font-16 ilf-title" href="/list/new-seven-wonders-of-the-world" >New Seven Wonders of the World</a> </div> </div> </div> </div> </div> </div> <button class="drawerToggle btn position-sticky border btn-xs btn-white btn-circle rounded-sm d-none d-lg-flex " type="button" aria-label="Toggle Drawer"> <em class="material-icons font-18 text-blue" data-icon="keyboard_arrow_left"></em> </button> </div> </div> <div class="col"> <div class="h-100 ml-0 pr-lg-0 "> <div class="h-100 grid gx-0 gx-lg-20"> <div class="h-100 col-sm"> <div class="h-100 infinite-pagination-container d-flex flex-column position-relative"> <div class="position-absolute top-0 h-100 w-100"> <div class="toc-sticky-header d-none d-lg-none bg-gray-50 px-10 px-sm-30 position-sticky w-100 "> <div class="toc-sticky-header-inner-container align-items-center d-flex mx-auto h-100 w-100"> <button class="d-flex d-lg-none btn btn-sm btn-white text-blue border-2 border-gray-100 gtm-mobile-toc-header-button js-sections-button d-lg-none p-10"> <em class="material-icons my-n5 md-icon" data-icon="toc"></em> Contents </button> <div class="header-ai-ask-button-placeholder"></div> <div class="header-ai-summarize-button-placeholder"></div> </div> </div> </div> <div class="grey-box w-100 grey-box-top"> <div class="grey-box-content mx-auto w-100"> <script type="application/ld+json"> { "@context" : "https://schema.org", "@type" : "BreadcrumbList", "itemListElement" : [ { "@type" : "ListItem", "position" : 1, "item" : { "@id" : "https://www.britannica.com/browse/Health-Medicine", "name": "Health & Medicine" } } , { "@type" : "ListItem", "position" : 2, "item" : { "@id" : "https://www.britannica.com/browse/Medicine", "name": "Medicine" } } ] } </script> <nav class="breadcrumb mt-20"> <span class="breadcrumb-item "> <a class="link-gray-600" href="/browse/Health-Medicine">Health & Medicine</a> </span> <span class="breadcrumb-item "> <a class="link-gray-600" href="/browse/Medicine">Medicine</a> </span> </nav> <div class="page2ref-true topic-content topic-type-REGULAR" data-student-article="true"> <script class="page-description-json" type="application/json"> { "url": "/science/genetic-engineering", "shareUrl": "https://www.britannica.com/science/genetic-engineering", "browserTitle": "Genetic engineering | Definition, Process, Uses, Examples, Techniques, & Facts", "firstTopicPage": true, "topicId":228897 } </script> <div class="reading-channel"> <div class="desktop-header-image module-spacing"> <figure class="md-assembly m-0 mb-20 mb-md-0 card card-borderless print-false" data-assembly-id="13684" data-asm-type="image"> <div class="md-assembly-wrapper card-media " data-type="image"> <a style="min-height: 160px;" href="https://cdn.britannica.com/73/187373-050-1564B18E/salmon-age-ability-genomes-questions-animals.jpg" class="gtm-assembly-link position-relative d-flex align-items-center justify-content-center media-overlay-link card-media" data-href="/media/1/228897/204864"> <picture> <source media="(min-width: 680px)" srcset="https://cdn.britannica.com/73/187373-050-1564B18E/salmon-age-ability-genomes-questions-animals.jpg?w=300"> <img src="https://cdn.britannica.com/73/187373-050-1564B18E/salmon-age-ability-genomes-questions-animals.jpg?w=400&h=300&c=crop" alt="genetically engineered salmon" loading="eager" /> </picture> <button class="magnifying-glass btn btn-circle position-absolute shadow btn-white top-10 right-10" aria-label="Zoom in"> <em class="material-icons link-blue" data-icon="zoom_in"></em> </button> </a> </div> <figcaption class="card-body"> <div class="md-assembly-caption text-muted font-14 font-serif line-clamp"> <span> <a class="gtm-assembly-link md-assembly-title font-weight-bold d-inline font-sans-serif mr-5 media-overlay-link" href="https://cdn.britannica.com/73/187373-050-1564B18E/salmon-age-ability-genomes-questions-animals.jpg" data-href="/media/1/228897/204864">genetically engineered salmon</a> <span><span>A genetically engineered salmon (top) and a natural salmon of the same age. The ability to engineer and precisely edit the genomes of animals, while potentially beneficial to humans, has raised ethical questions.</span></span> <button class="js-more-btn d-none btn btn-unstyled font-12 bg-white js-content" aria-label="Toggle more/less fact data"> <span class="link-blue">(more)</span> </button> </span> </div> </figcaption> </figure> </div><div class="topic-header"> <div class="d-flex align-items-top justify-content-between"> <div class="d-flex flex-column"> <div> <div> <h1>genetic engineering</h1></div> </div> </div> </div> <div class="d-none d-sm-flex flex-row"> <div class="mr-10 mb-15"> <button class="ai-ask-button btn border-2 btn-sm js-inline-ai-ask-button btn-outline-red-400 border-red-400"> Ask the Chatbot a Question </button> </div> <div class="d-block md-topic-tools qa-action-buttons mb-15" data-topic-id="228897"> <button class="js-tooltip btn btn-sm btn-outline-blue border pr-10 border-2 text-nowrap" > <em class="material-icons md-icon ml-n10 my-n5 mr-5" data-icon="more_vert"></em> More Actions </button> <div class="md-more-popover popover popover-sm p-0 font-14 z-1"> <div> <button class="js-print-modal-button js-modal gtm-topic-tool btn btn-sm btn-link gtm-topic-tool font-weight-bold btn-link" data-modal="[data-topic-id=228897] .md-print-modal" > <em class="material-icons mr-5 ml-n10 my-n5 md-icon" data-icon="print"></em> Print </button> <div class="md-print-modal size-lg d-none"> <div class="md-modal-body"> <div class="h2 font-serif d-flex align-items-center pb-15 border-bottom"> <em class="material-icons text-blue mr-10">print</em> Print </div> <div class="mt-20 mb-10"> Please select which sections you would like to print: </div> <form action="/print/article/228897" method="post" target="_blank" rel="noopener"> <div class="print-box-items"> <ul class="list-unstyled"> <li><label><input class="mr-10" type="checkbox" name="sequence[]" value="0">Table Of Contents</label></li> </ul> </div> <input type="submit" class="btn btn-blue md-disabled" value="Print" /> </form> </div> </div> </div> <div> <button class="js-modal qa-cite-modal-button btn btn-sm btn-link gtm-topic-tool font-weight-bold btn-link" data-modal="[data-topic-id=228897] .md-cite-modal"> <em class="material-icons mr-5 ml-n10 my-n5 md-icon" data-icon="verified"></em> Cite </button> <div class="md-cite-modal size-lg d-none"> <div class="md-modal-body"> <div class="h2 font-serif d-flex align-items-center pb-15 border-bottom mb-15"> <em class="material-icons text-blue mr-10">verified</em>Cite </div> <div class="font-serif"> While every effort has been made to follow citation style rules, there may be some discrepancies. Please refer to the appropriate style manual or other sources if you have any questions. </div> <div class="label mt-20 mb-10">Select Citation Style</div> <select class="js-citation-format-select form-select"> <option selected value="mla">MLA</option> <option value="apa">APA</option> <option value="chicago">Chicago Manual of Style</option> </select> <div class="citation font-serif border rounded p-15 mt-20" data-authors="The Editors of Encyclopaedia Britannica" data-authors-initial="The Editors of Encyclopaedia Britannica" data-title="genetic engineering" data-published-date="15 Feb. 2025" data-url="https://www.britannica.com/science/genetic-engineering" > <div class="citation-text"></div> </div> <button class="js-copy-citation-button mt-20 btn btn-xs btn-outline-blue border shadow-sm pr-10" > <em class="material-icons md-icon ml-n10 my-n5 mr-5" data-icon="file_copy"></em> <span class="js-citation-status-text">Copy Citation</span> </button> </div> </div> </div> <div> <button class="js-share-modal-button js-modal btn btn-sm btn-link gtm-topic-tool font-weight-bold btn-link" data-modal="[data-topic-id=228897] .md-share-modal"> <em class="material-icons mr-5 ml-n10 my-n5 md-icon" data-icon="share"></em> Share </button> <div class="md-share-modal size-lg d-none qa-share-modal"> <div class="md-modal-body"> <div class="h2 font-serif d-flex align-items-center pb-15 border-bottom"> <em class="material-icons text-blue mr-10" data-icon="share"></em> Share </div> <div class="label my-20">Share to social media</div> <div class="md-social-toolbar-circle d-flex align-items-start inverted" data-value="share" title="genetic engineering" data-url="https://www.britannica.com/science/genetic-engineering" > <a class="social-icon facebook justify-content-center d-flex align-items-center align-self-center" data-provider="facebook" href="https://www.facebook.com/BRITANNICA/" target="_blank" rel="noopener"><span>Facebook</span></a> <a class="social-icon x justify-content-center d-flex align-items-center align-self-center" data-provider="x" href="https://x.com/britannica" target="_blank" rel="noopener"><span>X</span></a> </div> <div class="label pt-20 mt-20 mb-5 border-top">URL</div> <a class="font-serif text-truncate d-inline-block" href="https://www.britannica.com/science/genetic-engineering">https://www.britannica.com/science/genetic-engineering</a> </div> </div> </div> <div> <button class="js-feedback-modal-button js-modal btn btn-sm btn-link gtm-topic-tool font-weight-bold btn-link" data-modal=".md-feedback-modal"> <em class="material-icons mr-5 ml-n10 my-n5 md-icon" data-icon="message"></em> Feedback </button> </div> <div> <button class="qa-external-website-modal-button js-modal btn btn-sm btn-link gtm-topic-tool font-weight-bold btn-link" data-modal="[data-topic-id=228897] .md-websites-modal"> <em class="material-icons md-icon ml-n10 mr-5" data-icon="link"></em> External Websites </button> </div> </div> <div class="md-feedback-modal size-lg d-none"> <div class="md-modal-body"> <div class="h2 font-serif pb-15 border-bottom"> Feedback </div> <form method="post" action="/submission/feedback/228897"> <div class="my-20"> Corrections? Updates? Omissions? Let us know if you have suggestions to improve this article (requires login). </div> <div class="type-menu"> <label for="feedback-type" class="label mb-10">Feedback Type</label> <select id="feedback-type" class="form-select mb-30" name="feedbackTypeId" required> <option value="" selected="selected">Select a type (Required)</option> <option value="1">Factual Correction</option> <option value="2">Spelling/Grammar Correction</option> <option value="3">Link Correction</option> <option value="4">Additional Information</option> <option value="5">Other</option> </select> </div> <label for="feedback" class="label mb-10">Your Feedback</label> <textarea id="feedback" class="form-control mb-30" name="feedback" maxlength="3000" rows="7" required></textarea> <button class="btn btn-blue" type="submit">Submit Feedback</button> </form> <div class="success-messaging d-none mt-30"> <div class="title">Thank you for your feedback</div> <p>Our editors will review what you’ve submitted and determine whether to revise the article.</p> </div> </div> </div> <div class="md-websites-modal size-lg d-none"> <div class="md-modal-body"> <div class="h2 font-serif pb-15 border-bottom font-weight-bold"> External Websites </div> <div class="pb-20"> <ul class="list-unstyled mt-20 lh-lg"> <li><a class="external" href="https://medicine.missouri.edu/centers-institutes-labs/health-ethics/faq/gene-therapy" target="_blank" rel="noopener ">University of Missouri - School of Medicine - Gene Therapy and Genetic Engineering</a></li> <li><a class="external" href="https://www.eolss.net/sample-chapters/c17/E6-58-03-04.pdf" target="_blank" rel="noopener ">UNESCO-EOLSS - Genetic Engineering of Plants (PDF)</a></li> <li><a class="external" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC3078015/" target="_blank" rel="noopener ">National Center for Biotechnology Information - PubMed Central - Genetic engineering of animals: Ethical issues, including welfare concerns</a></li> <li><a class="external" href="https://www.livescience.com/32648-whats-genetic-engineering.html" target="_blank" rel="noopener ">LiveScience - What's Genetic Engineering?</a></li> <li><a class="external" href="https://iastate.pressbooks.pub/genagbiotech/chapter/genetic-engineering/" target="_blank" rel="noopener ">Iowa State University Digital Press - Genetic Engineering</a></li> <li><a class="external" href="https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Principles_of_Biology/02%3A_Chapter_2/20%3A_Biotechnology/20.03%3A_Genetic_Engineering" target="_blank" rel="noopener ">Biology LibreTexts - Genetic Engineering</a></li> <li><a class="external" href="https://english.umd.edu/research-innovation/journals/interpolations/interpolations-spring-2011/genetic-engineering-serious" target="_blank" rel="noopener ">University of Marland - Department of English - Interpolations - Genetic Engineering: A Serious Threat to Human Society</a></li> <li><a class="external" href="https://agricultureandfoodsecurity.biomedcentral.com/articles/10.1186/2048-7010-2-15" target="_blank" rel="noopener ">BMC - Agriculture and Food Security - Genetic engineering for improving quality and productivity of crops</a></li> <li><a class="external" href="https://www.khanacademy.org/science/high-school-biology/hs-molecular-genetics/hs-biotechnology/v/introduction-to-genetic-engineering" target="_blank" rel="noopener ">Khan Academy - Introduction to genetic engineering</a></li> <li><a class="external" href="https://openbooks.lib.msu.edu/isb202/chapter/biotechnology/" target="_blank" rel="noopener ">OER at MSU Libraries - An Interactive Introduction to Organismal and Molecular Biology, 2nd ed. - Genetic Engineering</a></li> </ul> </div> <div class="md-websites-ebk-title">Britannica Websites</div> <div class="md-websites-ebk-subtitle">Articles from Britannica Encyclopedias for elementary and high school students.</div> <ul class="list-unstyled bps-topic-web-sites lh-lg"> <li><a class="external" href="https://kids.britannica.com/kids/article/genetic-engineering/600760" target="_blank" rel="noopener">genetic engineering - Children's Encyclopedia (Ages 8-11)</a></li> <li><a class="external" href="https://kids.britannica.com/students/article/genetic-engineering/274518" target="_blank" rel="noopener">genetic engineering - Student Encyclopedia (Ages 11 and up)</a></li> </ul> </div> </div> </div> </div> <div class="toc-header-marker"></div> <button class="ai-ask-button btn border-2 js-header-ai-ask-button d-none btn-sm btn-outline-red-400 border-red-400 mr-0 mr-lg-10 ml-5 ml-sm-10 ml-lg-0 p-10"> Ask the Chatbot a Question </button> <div class="md-byline module-spacing "> <div class="font-serif font-12"> <span class="written-by text-gray-700"> Written and fact-checked by </span> <div class="editor-popover popover p-0"> <a class="d-block p-20 qa-editor-popup gtm-byline font-12 byline-contributor" href="/editor/The-Editors-of-Encyclopaedia-Britannica/4419" > <div class="editor-title font-16 font-weight-bold">The Editors of Encyclopaedia Britannica</div> <div class="editor-description font-12 font-serif mt-5 text-black">Encyclopaedia Britannica's editors oversee subject areas in which they have extensive knowledge, whether from years of experience gained by working on that content or via study for an advanced degree. They write new content and verify and edit content received from contributors.</div> </a> <div data-popper-arrow></div> </div> <span class="btn btn-link editor-link p-0 qa-byline-link gtm-byline font-12 byline-contributor text-decoration-underline"> The Editors of Encyclopaedia Britannica</span></div> <div class="last-updated font-12 font-serif"> <span class="text-gray-700"> Last Updated: <time datetime="2025-02-15T00:00:00CST" >Feb 15, 2025</time> •</span> <a class="byline-edit-history" href="https://www.britannica.com/science/genetic-engineering/additional-info#history" rel="nofollow">Article History</a> </div></div> </div> <button class="d-flex d-lg-none btn btn-outline-blue border rounded-sm shadow-sm mobile-toc-button gtm-mobile-toc-inline-button d-none d-sm-block js-sections-inline-button module-spacing btn d-lg-none"> <em class="material-icons mr-5 ml-n10 my-n5 md-icon" data-icon="toc"></em> Table of Contents </button> <div class="d-flex d-sm-none flex-row"> <button class="d-flex d-lg-none btn btn-outline-blue border rounded-sm shadow-sm mobile-toc-button gtm-mobile-toc-inline-button js-sections-inline-button module-spacing"> <em class="material-icons mr-5 ml-n10 my-n5 md-icon" data-icon="toc"></em> Table of Contents </button> <button class="ai-ask-button btn border-2 ai-ask-button btn border-2 module-spacing btn-sm js-inline-ai-ask-button btn-outline-red-400 border-red-400 p-10 ml-5"> Ask the Chatbot a Question </button> </div> <div class="js-qf-module qf-module px-40 px-sm-20 py-15 mx-auto module-spacing font-14 bg-gray-50 rounded"> <div class="facts-list mt-10"> <div class=""> <div class="js-fact mb-10 line-clamp clamp-3"> <dl> <dt>Key People: </dt> <dd><a href="/biography/Ian-Wilmut" topicid="644616">Ian Wilmut</a></dd> <dd><a href="/biography/George-Ledyard-Stebbins-Jr" topicid="564612">George Ledyard Stebbins, Jr.</a></dd> </dl> <button class="js-more-btn d-none btn btn-unstyled font-12 bg-gray-50" aria-label="Toggle more/less fact data"> <em class="js-content link-blue">(Show more)</em> </button> </div> </div> <div class=""> <div class="js-fact mb-10 line-clamp clamp-3"> <dl> <dt>Related Topics: </dt> <dd><a href="/science/recombinant-DNA-technology" topicid="493667">recombinant DNA</a></dd> <dd><a href="/science/genetically-modified-organism" topicid="897705">genetically modified organism</a></dd> <dd><a href="/science/gene-editing" topicid="1998073">gene editing</a></dd> <dd><a href="/science/three-parent-baby" topicid="2002944">three-parent baby</a></dd> <dd><a href="/science/whole-genome-sequencing" topicid="1866136">whole genome sequencing</a></dd> </dl> <button class="js-more-btn d-none btn btn-unstyled font-12 bg-gray-50" aria-label="Toggle more/less fact data"> <em class="js-content link-blue">(Show more)</em> </button> </div> </div> <div class=""> <div class="js-fact mb-10 line-clamp clamp-3"> <dl> <dt>On the Web: </dt> <dd><a href="https://www.eolss.net/sample-chapters/c17/E6-58-03-04.pdf" target="_blank">UNESCO-EOLSS - Genetic Engineering of Plants (PDF)</a> (Feb. 15, 2025)</dd> </dl> <button class="js-more-btn d-none btn btn-unstyled font-12 bg-gray-50" aria-label="Toggle more/less fact data"> <em class="js-content link-blue">(Show more)</em> </button> </div> <div class="text-center"> <a class="btn btn-sm btn-link p-0" href="/facts/genetic-engineering"> See all related content </a> </div> </div> </div> </div><div class="ai-top-questions-module module-spacing ai-tq collapsed font-sans-serif"> <div class="font-weight-bold font-14"> Top Questions </div> <ul class="mt-5"> <li class="ai-qa-item mb-5 bg-gray-50 rounded "> <div class="ai-top-question justify-content-between align-items-center font-14 px-10 py-5 rounded " data-qn="0"> <div>What is genetic engineering?</div> </div> <div class="answer p-10 ui-hidden" data-loaded="false"></div> <div class="ai-loader ui-hidden" /> </li> <li class="ai-qa-item mb-5 bg-gray-50 rounded "> <div class="ai-top-question justify-content-between align-items-center font-14 px-10 py-5 rounded " data-qn="1"> <div>How does genetic engineering differ from traditional breeding methods?</div> </div> <div class="answer p-10 ui-hidden" data-loaded="false"></div> <div class="ai-loader ui-hidden" /> </li> <li class="ai-qa-item mb-5 bg-gray-50 rounded "> <div class="ai-top-question justify-content-between align-items-center font-14 px-10 py-5 rounded " data-qn="2"> <div>What are the main techniques used in genetic engineering?</div> </div> <div class="answer p-10 ui-hidden" data-loaded="false"></div> <div class="ai-loader ui-hidden" /> </li> <li class="ai-qa-item mb-5 bg-gray-50 rounded af3"> <div class="ai-top-question justify-content-between align-items-center font-14 px-10 py-5 rounded " data-qn="3"> <div>How do scientists alter the DNA of an organism?</div> </div> <div class="answer p-10 ui-hidden" data-loaded="false"></div> <div class="ai-loader ui-hidden" /> </li> <li class="ai-qa-item mb-5 bg-gray-50 rounded af3"> <div class="ai-top-question justify-content-between align-items-center font-14 px-10 py-5 rounded " data-qn="4"> <div>What are some of the goals of genetic engineering in agriculture?</div> </div> <div class="answer p-10 ui-hidden" data-loaded="false"></div> <div class="ai-loader ui-hidden" /> </li> <li class="ai-qa-item mb-5 bg-gray-50 rounded af3"> <div class="ai-top-question justify-content-between align-items-center font-14 px-10 py-5 rounded " data-qn="5"> <div>What role does genetic engineering play in medicine?</div> </div> <div class="answer p-10 ui-hidden" data-loaded="false"></div> <div class="ai-loader ui-hidden" /> </li> <li class="ai-qa-item mb-5 bg-gray-50 rounded af3"> <div class="ai-top-question justify-content-between align-items-center font-14 px-10 py-5 rounded " data-qn="6"> <div>What are the ethical concerns associated with genetic engineering?</div> </div> <div class="answer p-10 ui-hidden" data-loaded="false"></div> <div class="ai-loader ui-hidden" /> </li> <li class="ai-qa-item mb-5 bg-gray-50 rounded af3"> <div class="ai-top-question justify-content-between align-items-center font-14 px-10 py-5 rounded " data-qn="7"> <div>How is genetic engineering regulated by governments and organizations?</div> </div> <div class="answer p-10 ui-hidden" data-loaded="false"></div> <div class="ai-loader ui-hidden" /> </li> <li class="ai-qa-item mb-5 bg-gray-50 rounded af3"> <div class="ai-top-question justify-content-between align-items-center font-14 px-10 py-5 rounded " data-qn="8"> <div>What are some real-world examples where genetic engineering has been applied successfully?</div> </div> <div class="answer p-10 ui-hidden" data-loaded="false"></div> <div class="ai-loader ui-hidden" /> </li> </ul> <button class="show-more btn btn-unstyled font-14 p-5 pr-10 mb-10 rounded-sm d-none"><em class="material-icons " data-icon="expand_more"></em> Show more</button> <button class="show-less btn btn-unstyled font-14 p-5 pr-10 mb-10 rounded-sm"><em class="material-icons " data-icon="expand_less"></em> Show less</button> </div><span class="marker before-article"></span><section data-level="1" id="ref1"><span class="marker PREMOD1 mod-inline"></span><p class="topic-paragraph"><strong><span id="ref233967"></span>genetic engineering</strong>, the artificial manipulation, modification, and recombination of <a href="https://www.britannica.com/science/DNA" class="md-crosslink " data-show-preview="true">DNA</a> or other <a href="https://www.britannica.com/science/nucleic-acid" class="md-crosslink " data-show-preview="true">nucleic acid</a> <a href="https://www.britannica.com/science/molecule" class="md-crosslink " data-show-preview="true">molecules</a> in order to modify an <a href="https://www.britannica.com/science/multicellular-organism" class="md-crosslink " data-show-preview="true">organism</a> or <a href="https://www.britannica.com/science/population-biology-and-anthropology" class="md-crosslink " data-show-preview="true">population</a> of organisms. The term <em>genetic engineering</em> is generally used to refer to methods of <a href="https://www.britannica.com/science/recombinant-DNA-technology" class="md-crosslink " data-show-preview="true">recombinant DNA technology</a>, which emerged from basic research in microbial <a href="https://www.britannica.com/science/genetics" class="md-crosslink autoxref " data-show-preview="true">genetics</a>. The techniques employed in genetic engineering have led to the production of medically important products, including human <a href="https://www.britannica.com/science/insulin" class="md-crosslink " data-show-preview="true">insulin</a>, human <a href="https://www.britannica.com/science/growth-hormone" class="md-crosslink " data-show-preview="true">growth hormone</a>, and <a href="https://www.britannica.com/science/hepatitis-B" class="md-crosslink " data-show-preview="true">hepatitis B</a> <a href="https://www.britannica.com/science/vaccine" class="md-crosslink autoxref " data-show-preview="true">vaccine</a>, as well as to the development of <a href="https://www.britannica.com/science/genetically-modified-organism" class="md-crosslink " data-show-preview="true">genetically modified organisms</a> such as disease-resistant plants.</p><span class="marker MOD1 mod-inline"></span></section> <span class="marker h2"></span><section data-level="1" id="ref337079"> <h2 class="h1">Historical developments</h2> <span class="marker PREMOD2 mod-inline"></span><div class="assemblies"><div class="w-100"><figure class="md-assembly m-0 mb-md-0 card card-borderless print-false" data-assembly-id="280930" data-asm-type="video"><div class="md-assembly-wrapper card-media" data-type="video" video-id="240889"><a data-id="240889" class="gtm-assembly-link d-flex justify-content-center" style="--aspect-ratio: 16/9" href="/video/Genetically-Modified-Humans-CRISPR-Cas-9-Explained/-280930"><img src="https://cdn.britannica.com/89/240889-138-BE17294D/Genetically-Modified-Humans-CRISPR-Cas-9-Explained.jpg?w=800&h=450&c=crop" alt="genetically modified humans" loading="lazy"><script type="application/json"> { "sources": [ { "file" : "//content.jwplatform.com/manifests/cUmKL29W.m3u8" } ], "image": "https://cdn.britannica.com/89/240889-138-BE17294D/Genetically-Modified-Humans-CRISPR-Cas-9-Explained.jpg" ,"tracks": [ { "file" : "//assets-jpcust.jwpsrv.com/tracks/xTEcqdjD", "label": "English" } ] ,"adfile": "//content.jwplatform.com/manifests/yfUjoC1u.m3u8" } </script><div class="btn btn-xl btn-white btn-circle position-absolute shadow" style="top: 50%; transform: translateY(-50%)"><em class="material-icons" data-icon="play_arrow"></em></div></a></div><figcaption class="card-body"><div class="md-assembly-caption text-muted font-14 font-serif line-clamp"><span><span class="md-assembly-title font-weight-bold mr-5 d-inline font-sans-serif md-video-caption" video-control="240889">genetically modified humans</span><span>CRISPR and genetically modified humans.</span><button class="js-more-btn d-none btn btn-unstyled font-12 bg-white js-content" aria-label="Toggle more/less fact data"><span class="link-blue">(more)</span></button></span></div><a class="font-14 mt-10 d-inline-block" href="/science/genetic-engineering/images-videos">See all videos for this article</a></figcaption></figure></div></div><p class="topic-paragraph">The term <em>genetic engineering</em> initially referred to various techniques used for the modification or manipulation of organisms through the processes of <a href="https://www.britannica.com/science/heredity-genetics" class="md-crosslink " data-show-preview="true">heredity</a> and <a href="https://www.britannica.com/science/reproduction-biology" class="md-crosslink " data-show-preview="true">reproduction</a>. As such, the term embraced both <a href="https://www.britannica.com/science/selective-breeding" class="md-crosslink autoxref " data-show-preview="true">artificial selection</a> and all the interventions of biomedical techniques, among them <a href="https://www.britannica.com/science/artificial-insemination" class="md-crosslink autoxref " data-show-preview="true">artificial insemination</a>, <a href="https://www.britannica.com/science/in-vitro-fertilization" class="md-crosslink " data-show-preview="true">in vitro fertilization</a> (e.g., “test-tube” babies), <a href="https://www.britannica.com/science/cloning" class="md-crosslink " data-show-preview="true">cloning</a>, and <a href="https://www.britannica.com/science/gene" class="md-crosslink " data-show-preview="true">gene</a> manipulation. In the latter part of the 20th century, however, the term came to refer more specifically to methods of <span id="ref233969"></span><a href="https://www.britannica.com/science/recombinant-DNA-technology" class="md-crosslink " data-show-preview="true">recombinant DNA technology</a> (or <span id="ref233968"></span><a href="https://www.britannica.com/science/recombination-genetics" class="md-crosslink " data-show-preview="true">gene cloning</a>), in which DNA molecules from two or more sources are combined either within <a href="https://www.britannica.com/science/cell-biology" class="md-crosslink " data-show-preview="true">cells</a> or in vitro and are then inserted into host organisms in which they are able to <a class="md-dictionary-link md-dictionary-tt-off mw" data-term="propagate" href="https://www.merriam-webster.com/dictionary/propagate" data-type="MW">propagate</a>.</p><div class="one-good-fact-module"> </div><span class="marker MOD2 mod-inline"></span> <span class="marker PREMOD3 mod-inline"></span><p class="topic-paragraph">The possibility for <span id="ref1292909"></span><a href="https://www.britannica.com/science/recombinant-DNA-technology" class="md-crosslink " data-show-preview="true">recombinant DNA</a> <a href="https://www.britannica.com/technology/technology" class="md-crosslink autoxref " data-show-preview="true">technology</a> emerged with the discovery of <span id="ref661169"></span><a href="https://www.britannica.com/science/restriction-enzyme" class="md-crosslink " data-show-preview="true">restriction enzymes</a> in 1968 by Swiss microbiologist <a href="https://www.britannica.com/biography/Werner-Arber" class="md-crosslink " data-show-preview="true">Werner Arber</a>. The following year American microbiologist <a href="https://www.britannica.com/biography/Hamilton-O-Smith" class="md-crosslink " data-show-preview="true">Hamilton O. Smith</a> purified so-called <span id="ref661170"></span><a href="https://www.britannica.com/science/type-II-restriction-enzyme" class="md-crosslink ">type II restriction enzymes</a>, which were found to be essential to genetic engineering for their ability to <a class="md-dictionary-link md-dictionary-tt-off mw" data-term="cleave" href="https://www.merriam-webster.com/dictionary/cleave" data-type="MW">cleave</a> a specific site within the DNA (as opposed to type I restriction enzymes, which cleave DNA at random sites). Drawing on Smith’s work, American molecular biologist <a href="https://www.britannica.com/biography/Daniel-Nathans" class="md-crosslink " data-show-preview="true">Daniel Nathans</a> helped advance the technique of DNA recombination in 1970–71 and demonstrated that type II enzymes could be useful in genetic studies. Genetic engineering based on recombination was pioneered in 1973 by American biochemists <a href="https://www.britannica.com/biography/Stanley-Cohen" class="md-crosslink " data-show-preview="true">Stanley N. Cohen</a> and Herbert W. Boyer, who were among the first to cut DNA into fragments, rejoin different fragments, and insert the new genes into <a href="https://www.britannica.com/science/E-coli" class="md-crosslink " data-show-preview="true"><em>E. coli</em></a> <a href="https://www.britannica.com/science/bacteria" class="md-crosslink autoxref " data-show-preview="true">bacteria</a>, which then reproduced.</p><span class="marker MOD3 mod-inline"></span> </section> <span class="marker end-of-content"></span><span class="marker after-article"></span></div> <div id="chatbot-root"></div> </div> </div> </div> <div class="ai-dialog-placeholder"></div> </div> </div> <aside class="col-md-da-320"></aside> </div> </div> </div> </div> </article> </div> </div> </div> </div> </main> <div id="md-footer"></div> <noscript><iframe src="//www.googletagmanager.com/ns.html?id=GTM-5W6NC8" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <script type="text/javascript" id="_informizely_script_tag"> var IzWidget = IzWidget || {}; (function (d) { var scriptElement = d.createElement('script'); scriptElement.type = 'text/javascript'; scriptElement.async = true; scriptElement.src = "https://insitez.blob.core.windows.net/site/f780f33e-a610-4ac2-af81-3eb184037547.js"; var node = d.getElementById('_informizely_script_tag'); node.parentNode.insertBefore(scriptElement, node); } )(document); </script>  <script> window.ap3c = window.ap3c || {}; var ap3c = window.ap3c; ap3c.cmd = ap3c.cmd || []; ap3c.cmd.push(function() { ap3c.init('ZO4siT4cLwnykPnzZWJtd3Byb2Q', 'https://engage.email.britannica.com/'); ap3c.track({v: 0}); }); ap3c.activity = function(act) { ap3c.act = (ap3c.act || []); ap3c.act.push(act); }; var s, t; s = document.createElement('script'); s.type = 'text/javascript'; s.src = "https://engage.email.britannica.com/app.js"; t = document.getElementsByTagName('script')[0]; t.parentNode.insertBefore(s, t); </script> <script class="marketing-page-info" type="application/json"> {"pageType":"Topic","templateName":"DESKTOP","pageNumber":1,"pagesTotal":2,"pageId":228897,"pageLength":374,"initialLoad":true,"lastPageOfScroll":false} </script> <script class="marketing-content-info" type="application/json"> [] </script> <script src="https://cdn.britannica.com/mendel-resources/3-133/js/libs/jquery-3.5.0.min.js?v=3.133.9"></script> <script type="text/javascript" data-type="Init Mendel Code Splitting"> (function() { $.ajax({ dataType: 'script', cache: true, url: 'https://cdn.britannica.com/mendel-resources/3-133/dist/topic-page.js?v=3.133.9' }); })(); </script> <script class="analytics-metadata" type="application/json"> {"leg":"D","adLeg":"D","userType":"ANONYMOUS","pageType":"Topic","pageSubtype":null,"articleTemplateType":"PAGINATED","gisted":false,"pageNumber":1,"hasSummarizeButton":false,"hasAskButton":true} </script> <script type="text/javascript"> EBStat={accountId:-1,hostnameOverride:'webstats.eb.com',domain:'www.britannica.com', json:''}; </script> <script type="text/javascript"> ( function() { $.ajax( { dataType: 'script', cache: true, url: '//www.britannica.com/webstats/mendelstats.js?v=1' } ) .done( function() { try {writeStat(null,EBStat);} catch(err){} } ); })(); </script> <div id="bc-fixed-dialogue"></div> </body> </html>

CINXE.COM

Genetic engineering | Definition, Process, Uses, Examples, Techniques, & Facts | Britannica