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</label> <div class="vector-dropdown-content"> <div id="vector-appearance-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div id="p-vector-user-menu-notifications" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="//donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_sl.wikipedia.org&uselang=sl" class=""><span>Denarni prispevki</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Posebno:Registracija&returnto=Progesteron" 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href="/wiki/Posebno:MojPogovor" title="Pogovor o urejanjih s tega IP-naslova [n]" accesskey="n"><span>Pogovorna stran</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Projekt"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Vsebina" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Vsebina</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">prestavi v stransko letvico</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">skrij</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Uvod</div> </a> </li> <li id="toc-Odkritje" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Odkritje"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Odkritje</span> </div> </a> <ul id="toc-Odkritje-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Sinteza" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Sinteza"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Sinteza</span> </div> </a> <button aria-controls="toc-Sinteza-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Vklopi podrazdelek Sinteza</span> </button> <ul id="toc-Sinteza-sublist" class="vector-toc-list"> <li id="toc-Biosinteza" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Biosinteza"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Biosinteza</span> </div> </a> <ul id="toc-Biosinteza-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Laboratorijska_sinteza" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Laboratorijska_sinteza"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>Laboratorijska sinteza</span> </div> </a> <ul id="toc-Laboratorijska_sinteza-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Pomanjkanje" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Pomanjkanje"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Pomanjkanje</span> </div> </a> <button aria-controls="toc-Pomanjkanje-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Vklopi podrazdelek Pomanjkanje</span> </button> <ul id="toc-Pomanjkanje-sublist" class="vector-toc-list"> <li id="toc-Simptomi_pomanjkanja_progesterona" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Simptomi_pomanjkanja_progesterona"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1</span> <span>Simptomi pomanjkanja progesterona</span> </div> </a> <ul id="toc-Simptomi_pomanjkanja_progesterona-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Uporaba" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Uporaba"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Uporaba</span> </div> </a> <ul id="toc-Uporaba-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Sklici" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Sklici"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Sklici</span> </div> </a> <ul id="toc-Sklici-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Vsebina" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Vklopi kazalo vsebine" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Vklopi kazalo vsebine</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Progesteron</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="P9jdi na članek v drugem jeziku. Na voljo v 58 jezikih." > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-58" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">58 jezikov</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A8%D8%B1%D9%88%D8%AC%D8%B3%D8%AA%D9%8A%D8%B1%D9%88%D9%86" title="بروجستيرون – arabščina" lang="ar" hreflang="ar" data-title="بروجستيرون" data-language-autonym="العربية" data-language-local-name="arabščina" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-az mw-list-item"><a href="https://az.wikipedia.org/wiki/Progesteron" title="Progesteron – azerbajdžanščina" lang="az" hreflang="az" data-title="Progesteron" data-language-autonym="Azərbaycanca" data-language-local-name="azerbajdžanščina" class="interlanguage-link-target"><span>Azərbaycanca</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D9%BE%D8%B1%D9%88%DA%98%D8%B3%D8%AA%D8%B1%D9%88%D9%86" title="پروژسترون – South Azerbaijani" lang="azb" hreflang="azb" data-title="پروژسترون" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-be mw-list-item"><a href="https://be.wikipedia.org/wiki/%D0%9F%D1%80%D0%B0%D0%B3%D0%B5%D1%81%D1%82%D1%8D%D1%80%D0%BE%D0%BD" title="Прагестэрон – beloruščina" lang="be" hreflang="be" data-title="Прагестэрон" data-language-autonym="Беларуская" data-language-local-name="beloruščina" class="interlanguage-link-target"><span>Беларуская</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%9F%D1%80%D0%BE%D0%B3%D0%B5%D1%81%D1%82%D0%B5%D1%80%D0%BE%D0%BD" title="Прогестерон – bolgarščina" lang="bg" hreflang="bg" data-title="Прогестерон" data-language-autonym="Български" data-language-local-name="bolgarščina" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-bn mw-list-item"><a href="https://bn.wikipedia.org/wiki/%E0%A6%AA%E0%A7%8D%E0%A6%B0%E0%A7%8B%E0%A6%9C%E0%A7%87%E0%A6%B8%E0%A7%8D%E0%A6%9F%E0%A7%87%E0%A6%B0%E0%A6%A8" title="প্রোজেস্টেরন – bengalščina" lang="bn" hreflang="bn" data-title="প্রোজেস্টেরন" data-language-autonym="বাংলা" data-language-local-name="bengalščina" class="interlanguage-link-target"><span>বাংলা</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Progesteron" title="Progesteron – bosanščina" lang="bs" hreflang="bs" data-title="Progesteron" data-language-autonym="Bosanski" data-language-local-name="bosanščina" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Progesterona" title="Progesterona – katalonščina" lang="ca" hreflang="ca" data-title="Progesterona" data-language-autonym="Català" data-language-local-name="katalonščina" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-ckb mw-list-item"><a href="https://ckb.wikipedia.org/wiki/%D9%BE%DA%95%DB%86%D8%AC%DB%8E%D8%B3%D8%AA%D8%B1%DB%86%D9%86" title="پڕۆجێسترۆن – osrednja kurdščina" lang="ckb" hreflang="ckb" data-title="پڕۆجێسترۆن" data-language-autonym="کوردی" data-language-local-name="osrednja kurdščina" class="interlanguage-link-target"><span>کوردی</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Progesteron" title="Progesteron – češčina" lang="cs" hreflang="cs" data-title="Progesteron" data-language-autonym="Čeština" data-language-local-name="češčina" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/Progesteron" title="Progesteron – valižanščina" lang="cy" hreflang="cy" data-title="Progesteron" data-language-autonym="Cymraeg" data-language-local-name="valižanščina" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Progesteron" title="Progesteron – danščina" lang="da" hreflang="da" data-title="Progesteron" data-language-autonym="Dansk" data-language-local-name="danščina" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Progesteron" title="Progesteron – nemščina" lang="de" hreflang="de" data-title="Progesteron" data-language-autonym="Deutsch" data-language-local-name="nemščina" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-dv mw-list-item"><a href="https://dv.wikipedia.org/wiki/%DE%95%DE%B0%DE%83%DE%AF%DE%96%DE%AC%DE%90%DE%B0%DE%93%DE%A6%DE%83%DE%AF%DE%82%DE%B0" title="ޕްރޯޖެސްޓަރޯން – diveščina" lang="dv" hreflang="dv" data-title="ޕްރޯޖެސްޓަރޯން" data-language-autonym="ދިވެހިބަސް" data-language-local-name="diveščina" class="interlanguage-link-target"><span>ދިވެހިބަސް</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%A0%CF%81%CE%BF%CE%B3%CE%B5%CF%83%CF%84%CE%B5%CF%81%CF%8C%CE%BD%CE%B7" title="Προγεστερόνη – grščina" lang="el" hreflang="el" data-title="Προγεστερόνη" data-language-autonym="Ελληνικά" data-language-local-name="grščina" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Progesterone" title="Progesterone – angleščina" lang="en" hreflang="en" data-title="Progesterone" data-language-autonym="English" data-language-local-name="angleščina" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Progesterona" title="Progesterona – španščina" lang="es" hreflang="es" data-title="Progesterona" data-language-autonym="Español" data-language-local-name="španščina" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Progesteroon" title="Progesteroon – estonščina" lang="et" hreflang="et" data-title="Progesteroon" data-language-autonym="Eesti" data-language-local-name="estonščina" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Progesterona" title="Progesterona – baskovščina" lang="eu" hreflang="eu" data-title="Progesterona" data-language-autonym="Euskara" data-language-local-name="baskovščina" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%BE%D8%B1%D9%88%DA%98%D8%B3%D8%AA%D8%B1%D9%88%D9%86" title="پروژسترون – perzijščina" lang="fa" hreflang="fa" data-title="پروژسترون" data-language-autonym="فارسی" data-language-local-name="perzijščina" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Keltarauhashormoni" title="Keltarauhashormoni – finščina" lang="fi" hreflang="fi" data-title="Keltarauhashormoni" data-language-autonym="Suomi" data-language-local-name="finščina" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Progest%C3%A9rone" title="Progestérone – francoščina" lang="fr" hreflang="fr" data-title="Progestérone" data-language-autonym="Français" data-language-local-name="francoščina" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ga mw-list-item"><a href="https://ga.wikipedia.org/wiki/Pr%C3%B3gaist%C3%A9ar%C3%B3n" title="Prógaistéarón – irščina" lang="ga" hreflang="ga" data-title="Prógaistéarón" data-language-autonym="Gaeilge" data-language-local-name="irščina" class="interlanguage-link-target"><span>Gaeilge</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Proxesterona" title="Proxesterona – galicijščina" lang="gl" hreflang="gl" data-title="Proxesterona" data-language-autonym="Galego" data-language-local-name="galicijščina" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%A4%D7%A8%D7%95%D7%92%D7%A1%D7%98%D7%A8%D7%95%D7%9F" title="פרוגסטרון – hebrejščina" lang="he" hreflang="he" data-title="פרוגסטרון" data-language-autonym="עברית" data-language-local-name="hebrejščina" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/S%C3%A1rgatesthormon" title="Sárgatesthormon – madžarščina" lang="hu" hreflang="hu" data-title="Sárgatesthormon" data-language-autonym="Magyar" data-language-local-name="madžarščina" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D5%8A%D6%80%D5%B8%D5%A3%D5%A5%D5%BD%D5%BF%D5%A5%D6%80%D5%B8%D5%B6" title="Պրոգեստերոն – armenščina" lang="hy" hreflang="hy" data-title="Պրոգեստերոն" data-language-autonym="Հայերեն" data-language-local-name="armenščina" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Progesteron" title="Progesteron – indonezijščina" lang="id" hreflang="id" data-title="Progesteron" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonezijščina" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Progesterone" title="Progesterone – italijanščina" lang="it" hreflang="it" data-title="Progesterone" data-language-autonym="Italiano" data-language-local-name="italijanščina" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%97%E3%83%AD%E3%82%B2%E3%82%B9%E3%83%86%E3%83%AD%E3%83%B3" title="プロゲステロン – japonščina" lang="ja" hreflang="ja" data-title="プロゲステロン" data-language-autonym="日本語" data-language-local-name="japonščina" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%ED%99%A9%EC%B2%B4_%ED%98%B8%EB%A5%B4%EB%AA%AC" title="황체 호르몬 – korejščina" lang="ko" hreflang="ko" data-title="황체 호르몬" data-language-autonym="한국어" data-language-local-name="korejščina" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-ku mw-list-item"><a href="https://ku.wikipedia.org/wiki/Procesteron" title="Procesteron – kurdščina" lang="ku" hreflang="ku" data-title="Procesteron" data-language-autonym="Kurdî" data-language-local-name="kurdščina" class="interlanguage-link-target"><span>Kurdî</span></a></li><li class="interlanguage-link interwiki-ky mw-list-item"><a href="https://ky.wikipedia.org/wiki/%D0%9F%D1%80%D0%BE%D0%B3%D0%B5%D1%81%D1%82%D0%B5%D1%80%D0%BE%D0%BD" title="Прогестерон – kirgiščina" lang="ky" hreflang="ky" data-title="Прогестерон" data-language-autonym="Кыргызча" data-language-local-name="kirgiščina" class="interlanguage-link-target"><span>Кыргызча</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Progesteronas" title="Progesteronas – litovščina" lang="lt" hreflang="lt" data-title="Progesteronas" data-language-autonym="Lietuvių" data-language-local-name="litovščina" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%9F%D1%80%D0%BE%D0%B3%D0%B5%D1%81%D1%82%D0%B5%D1%80%D0%BE%D0%BD" title="Прогестерон – makedonščina" lang="mk" hreflang="mk" data-title="Прогестерон" data-language-autonym="Македонски" data-language-local-name="makedonščina" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-ml mw-list-item"><a href="https://ml.wikipedia.org/wiki/%E0%B4%AA%E0%B5%8D%E0%B4%B0%E0%B5%8A%E0%B4%9C%E0%B4%B8%E0%B5%8D%E0%B4%B1%E0%B5%8D%E0%B4%B1%E0%B4%BF%E0%B4%B1%E0%B5%8B%E0%B5%BA" title="പ്രൊജസ്റ്റിറോൺ – malajalamščina" lang="ml" hreflang="ml" data-title="പ്രൊജസ്റ്റിറോൺ" data-language-autonym="മലയാളം" data-language-local-name="malajalamščina" class="interlanguage-link-target"><span>മലയാളം</span></a></li><li class="interlanguage-link interwiki-mr mw-list-item"><a href="https://mr.wikipedia.org/wiki/%E0%A4%AA%E0%A5%8D%E0%A4%B0%E0%A5%8B%E0%A4%9C%E0%A5%87%E0%A4%B8%E0%A5%8D%E0%A4%9F%E0%A5%87%E0%A4%B0%E0%A5%89%E0%A4%A8" title="प्रोजेस्टेरॉन – maratščina" lang="mr" hreflang="mr" data-title="प्रोजेस्टेरॉन" data-language-autonym="मराठी" data-language-local-name="maratščina" class="interlanguage-link-target"><span>मराठी</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Progesteron" title="Progesteron – nizozemščina" lang="nl" hreflang="nl" data-title="Progesteron" data-language-autonym="Nederlands" data-language-local-name="nizozemščina" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Progesteron" title="Progesteron – knjižna norveščina" lang="nb" hreflang="nb" data-title="Progesteron" data-language-autonym="Norsk bokmål" data-language-local-name="knjižna norveščina" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-oc mw-list-item"><a href="https://oc.wikipedia.org/wiki/Progesterona" title="Progesterona – okcitanščina" lang="oc" hreflang="oc" data-title="Progesterona" data-language-autonym="Occitan" data-language-local-name="okcitanščina" class="interlanguage-link-target"><span>Occitan</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Progesteron" title="Progesteron – poljščina" lang="pl" hreflang="pl" data-title="Progesteron" data-language-autonym="Polski" data-language-local-name="poljščina" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Progesterona" title="Progesterona – portugalščina" lang="pt" hreflang="pt" data-title="Progesterona" data-language-autonym="Português" data-language-local-name="portugalščina" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Progesteron" title="Progesteron – romunščina" lang="ro" hreflang="ro" data-title="Progesteron" data-language-autonym="Română" data-language-local-name="romunščina" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%9F%D1%80%D0%BE%D0%B3%D0%B5%D1%81%D1%82%D0%B5%D1%80%D0%BE%D0%BD" title="Прогестерон – ruščina" lang="ru" hreflang="ru" data-title="Прогестерон" data-language-autonym="Русский" data-language-local-name="ruščina" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Progesteron" title="Progesteron – srbohrvaščina" lang="sh" hreflang="sh" data-title="Progesteron" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="srbohrvaščina" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Progesterone" title="Progesterone – Simple English" lang="en-simple" hreflang="en-simple" data-title="Progesterone" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Progester%C3%B3n" title="Progesterón – slovaščina" lang="sk" hreflang="sk" data-title="Progesterón" data-language-autonym="Slovenčina" data-language-local-name="slovaščina" class="interlanguage-link-target"><span>Slovenčina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Progesteron" title="Progesteron – srbščina" lang="sr" hreflang="sr" data-title="Progesteron" data-language-autonym="Српски / srpski" data-language-local-name="srbščina" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Progesteron" title="Progesteron – švedščina" lang="sv" hreflang="sv" data-title="Progesteron" data-language-autonym="Svenska" data-language-local-name="švedščina" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%AA%E0%AF%81%E0%AE%B0%E0%AF%8B%E0%AE%9C%E0%AF%86%E0%AE%B8%E0%AF%8D%E0%AE%9F%E0%AE%BF%E0%AE%B0%E0%AF%8B%E0%AE%A9%E0%AF%8D" title="புரோஜெஸ்டிரோன் – tamilščina" lang="ta" hreflang="ta" data-title="புரோஜெஸ்டிரோன்" data-language-autonym="தமிழ்" data-language-local-name="tamilščina" class="interlanguage-link-target"><span>தமிழ்</span></a></li><li class="interlanguage-link interwiki-te mw-list-item"><a href="https://te.wikipedia.org/wiki/%E0%B0%AA%E0%B1%8D%E0%B0%B0%E0%B1%8A%E0%B0%9C%E0%B1%86%E0%B0%B8%E0%B1%8D%E0%B0%9F%E0%B1%86%E0%B0%B0%E0%B0%BE%E0%B0%A8%E0%B1%8D" title="ప్రొజెస్టెరాన్ – telugijščina" lang="te" hreflang="te" data-title="ప్రొజెస్టెరాన్" data-language-autonym="తెలుగు" data-language-local-name="telugijščina" class="interlanguage-link-target"><span>తెలుగు</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B9%82%E0%B8%9E%E0%B8%A3%E0%B9%80%E0%B8%88%E0%B8%AA%E0%B9%80%E0%B8%97%E0%B8%AD%E0%B9%82%E0%B8%A3%E0%B8%99" title="โพรเจสเทอโรน – tajščina" lang="th" hreflang="th" data-title="โพรเจสเทอโรน" data-language-autonym="ไทย" data-language-local-name="tajščina" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Progesteron" title="Progesteron – turščina" lang="tr" hreflang="tr" data-title="Progesteron" data-language-autonym="Türkçe" data-language-local-name="turščina" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%9F%D1%80%D0%BE%D0%B3%D0%B5%D1%81%D1%82%D0%B5%D1%80%D0%BE%D0%BD" title="Прогестерон – ukrajinščina" lang="uk" hreflang="uk" data-title="Прогестерон" data-language-autonym="Українська" data-language-local-name="ukrajinščina" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Progesteron" title="Progesteron – uzbeščina" lang="uz" hreflang="uz" data-title="Progesteron" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="uzbeščina" class="interlanguage-link-target"><span>Oʻzbekcha / ўзбекча</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Progesterone" title="Progesterone – vietnamščina" lang="vi" hreflang="vi" data-title="Progesterone" data-language-autonym="Tiếng Việt" data-language-local-name="vietnamščina" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E5%AD%95%E9%85%AE" title="孕酮 – kitajščina" lang="zh" hreflang="zh" data-title="孕酮" data-language-autonym="中文" data-language-local-name="kitajščina" class="interlanguage-link-target"><span>中文</span></a></li><li class="interlanguage-link interwiki-zh-yue mw-list-item"><a href="https://zh-yue.wikipedia.org/wiki/%E9%BB%83%E9%AB%94%E7%B4%A0" title="黃體素 – kantonščina" lang="yue" hreflang="yue" data-title="黃體素" data-language-autonym="粵語" data-language-local-name="kantonščina" class="interlanguage-link-target"><span>粵語</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q26963#sitelinks-wikipedia" title="Uredi medjezikovne povezave" class="wbc-editpage">Uredi povezave</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Imenski prostori"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Progesteron" title="Ogled vsebinske strani [c]" accesskey="c"><span>Stran</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Pogovor:Progesteron" rel="discussion" title="Pogovor o vsebinski strani [t]" accesskey="t"><span>Pogovor</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Spremeni različico jezika" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" 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cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Orodja</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Orodja</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">prestavi v stransko letvico</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">skrij</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Več možnosti" > <div class="vector-menu-heading"> Dejanja </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Progesteron"><span>Preberi</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Progesteron&veaction=edit" title="Uredite to stran [v]" accesskey="v"><span>Uredi stran</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Progesteron&action=edit" title="Uredi izvorno kodo te strani [e]" accesskey="e"><span>Uredi kodo</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Progesteron&action=history"><span>Zgodovina</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> Splošno </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Posebno:KajSePovezujeSem/Progesteron" title="Seznam vseh strani, ki se povezujejo sem [j]" accesskey="j"><span>Kaj se povezuje sem</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Posebno:RecentChangesLinked/Progesteron" rel="nofollow" title="Zadnje spremembe na straneh, s katerimi se povezuje ta stran [k]" accesskey="k"><span>Povezane spremembe</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Posebno:PosebneStrani" title="Seznam vseh posebnih strani [q]" accesskey="q"><span>Posebne strani</span></a></li><li id="t-permalink" class="mw-list-item"><a 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wb-otherproject-commons mw-list-item"><a href="https://commons.wikimedia.org/wiki/Category:Progesterone" hreflang="en"><span>Wikimedijina zbirka</span></a></li><li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q26963" title="Povezava na ustrezni predmet v podatkovni shrambi [g]" accesskey="g"><span>Predmet v Wikipodatkih</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Orodja strani"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Videz"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Videz</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">prestavi v stransko letvico</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">skrij</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Iz Wikipedije, proste enciklopedije</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="sl" dir="ltr"><style data-mw-deduplicate="TemplateStyles:r5913888">.mw-parser-output .infobox{border:1px solid #a2a9b1;border-spacing:3px;background-color:#f8f9fa;color:black;margin:0.5em 0 0.5em 1em;padding:0.2em;float:right;clear:right;font-size:88%;line-height:1.5em;width:22em}.mw-parser-output .infobox-header,.mw-parser-output .infobox-label,.mw-parser-output .infobox-above,.mw-parser-output .infobox-full-data,.mw-parser-output .infobox-data,.mw-parser-output .infobox-below,.mw-parser-output .infobox-subheader,.mw-parser-output .infobox-image,.mw-parser-output .infobox-navbar,.mw-parser-output .infobox th,.mw-parser-output .infobox td{vertical-align:top}.mw-parser-output .infobox-label,.mw-parser-output .infobox-data,.mw-parser-output .infobox th,.mw-parser-output .infobox td{text-align:left}.mw-parser-output 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.infobox-below{text-align:center}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="Mednarodno nezaščiteno ime (INN): Progesteron">Progesteron</span></caption><tbody><tr><td colspan="2" class="infobox-image"><span typeof="mw:File"><a href="/wiki/Slika:Progesteron.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/6d/Progesteron.svg/230px-Progesteron.svg.png" decoding="async" width="230" height="162" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/6d/Progesteron.svg/345px-Progesteron.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/6d/Progesteron.svg/460px-Progesteron.svg.png 2x" data-file-width="297" data-file-height="209" /></a></span></td></tr><tr><td colspan="2" class="infobox-image"><span typeof="mw:File"><a href="/wiki/Slika:Progesterone-3D-balls.png" class="mw-file-description"><img alt="Molekula progesterona" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Progesterone-3D-balls.png/230px-Progesterone-3D-balls.png" decoding="async" width="230" height="152" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Progesterone-3D-balls.png/345px-Progesterone-3D-balls.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/73/Progesterone-3D-balls.png/460px-Progesterone-3D-balls.png 2x" data-file-width="2000" data-file-height="1324" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Klinični podatki</th></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;">Blagovne znamke</th><td class="infobox-data">Crinone, Endometrin</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Sinonim" class="mw-redirect" title="Sinonim">Sinonimi</a></th><td class="infobox-data">4-pregnen-3,20-dion</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=American_Society_of_Health-System_Pharmacists&action=edit&redlink=1" class="new" title="American Society of Health-System Pharmacists (stran ne obstaja)">AHFS</a>/<a href="/w/index.php?title=Drugs.com&action=edit&redlink=1" class="new" title="Drugs.com (stran ne obstaja)">Drugs.com</a></th><td class="infobox-data"><span class="reflink plainlinks nourlexpansion"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/progesterone.html">monograph</a></span></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></th><td class="infobox-data"><span title="medlineplus.gov"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a604017.html">a604017</a></span></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Zdravila_in_nose%C4%8Dnost" class="mw-redirect" title="Zdravila in nosečnost">Nosečnostna<br />kategorija</a></th><td class="infobox-data"><div class="plainlist"> <ul><li>B (<a href="/wiki/ZDA" class="mw-redirect" title="ZDA">ZDA</a>)</li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Na%C4%8Din_uporabe_zdravila" class="mw-redirect" title="Način uporabe zdravila">Način uporabe</a></th><td class="infobox-data">peroralno, <a href="/w/index.php?title=Implantat&action=edit&redlink=1" class="new" title="Implantat (stran ne obstaja)">implantat</a>, transdermalno</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Anatomsko-terapevtsko-kemi%C4%8Dni_klasifikacijski_sistem" title="Anatomsko-terapevtsko-kemični klasifikacijski sistem">Oznaka ATC</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r5911185">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"><ul><li><a href="/w/index.php?title=ATC-koda_G03&action=edit&redlink=1" class="new" title="ATC-koda G03 (stran ne obstaja)">G03DA04</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=G03DA04">WHO</a></span>) </li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd"><a href="/wiki/Farmakokinetika" title="Farmakokinetika">Farmakokinetični</a> podatki</th></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Biolo%C5%A1ka_razpolo%C5%BEljivost" class="mw-redirect" title="Biološka razpoložljivost">Biološka razpoložljivost</a></th><td class="infobox-data">podaljšana absorpcija, <a href="/wiki/Razpolovni_%C4%8Das" title="Razpolovni čas">razpolovni čas</a> okoli 25–50 ur</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Vezava_na_plazemske_beljakovine" title="Vezava na plazemske beljakovine">Vezava na beljakovine</a></th><td class="infobox-data">96–99 %</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Presnova_u%C4%8Dinkovine" title="Presnova učinkovine">Presnova</a></th><td class="infobox-data"><a href="/wiki/Jetra" title="Jetra">jetrna</a> do pregnanediola in pregnanolonov</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Biolo%C5%A1ki_razpolovni_%C4%8Das&action=edit&redlink=1" class="new" title="Biološki razpolovni čas (stran ne obstaja)">Razpolovni čas</a></th><td class="infobox-data">34,8–55,13 h</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Izlo%C4%8Danje" title="Izločanje">Izločanje</a></th><td class="infobox-data">skozi <a href="/wiki/Ledvice" class="mw-redirect" title="Ledvice">ledvice</a></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifikatorji</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Nomenklatura_Mednarodne_zveze_za_%C4%8Disto_in_uporabno_kemijo" class="mw-redirect" title="Nomenklatura Mednarodne zveze za čisto in uporabno kemijo">IUPAC ime</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><span style="font-size: 11px;">Pregn-4-en-3,20-dion</span></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/%C5%A0tevilka_CAS" title="Številka CAS">Številka CAS</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="www.commonchemistry.org"><a rel="nofollow" class="external text" href="http://www.commonchemistry.org/ChemicalDetail.aspx?ref=57-83-0">57-83-0</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><span class="abbr" style="border-bottom: 1px dotted" title="Compound ID">CID</span></span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/5994">5994</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Guide_to_Pharmacology&action=edit&redlink=1" class="new" title="Guide to Pharmacology (stran ne obstaja)">IUPHAR/BPS</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="www.guidetopharmacology.org"><a rel="nofollow" class="external text" href="http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2377">2377</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=DrugBank&action=edit&redlink=1" class="new" title="DrugBank (stran ne obstaja)">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB00396">DB00396</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="http://www.chemspider.com/Chemical-Structure.5773.html">5773</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Unique_Ingredient_Identifier&action=edit&redlink=1" class="new" title="Unique Ingredient Identifier (stran ne obstaja)">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="fdasis.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=4G7DS2Q64Y">4G7DS2Q64Y</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="http://www.kegg.jp/entry/D00066">D00066</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/ChEBI" title="ChEBI">ChEBI</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:17026">CHEBI:17026</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/ChEMBL103">ChEMBL103</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<span class="abbr" style="border-bottom: 1px dotted" title="U.S. Environmental Protection Agency">EPA</span>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/DTXSID3022370">DTXSID3022370</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q26963#P3117" title="Uredite to na Wikipodatkih"><img alt="Uredite to na Wikipodatkih" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/ECHA_InfoCard" class="mw-redirect" title="ECHA InfoCard"><span title="echa.europa.eu">ECHA InfoCard</span></a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.000.318">100.000.318</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q26963#P2566" title="Uredite to na Wikipodatkih"><img alt="Uredite to na Wikipodatkih" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Kemični in fizikalni podatki</th></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Kemi%C4%8Dna_formula" class="mw-redirect" title="Kemična formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>21</sub><span title="Vodik">H</span><sub>30</sub><span title="Kisik">O</span><sub>2</sub></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Molekulska_masa" title="Molekulska masa">Mol. masa</a></th><td class="infobox-data">314,46</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=O%3DC4%5CC%3DC2%2F%5BC%40%5D%28%5BC%40H%5D1CC%5BC%40%40%5D3%28%5BC%40%40H%5D%28C%28%3DO%29C%29CC%5BC%40H%5D3%5BC%40%40H%5D1CC2%29C%29%28C%29CC4">Interactive image</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Specifi%C4%8Dna_rotacija&action=edit&redlink=1" class="new" title="Specifična rotacija (stran ne obstaja)">Specifična rotacija</a></th><td class="infobox-data">[α]<sub>D</sub></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Tali%C5%A1%C4%8De" title="Tališče">Tališče</a></th><td class="infobox-data">126 °C</td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:11px; line-height:120%;">O=C4\C=C2/[C@]([C@H]1CC[C@@]3([C@@H](C(=O)C)CC[C@H]3[C@@H]1CC2)C)(C)CC4</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" class="mw-redirect" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:11px; line-height:120%;">InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1</div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:11px; line-height:120%;">Key:RJKFOVLPORLFTN-LEKSSAKUSA-N</div></li></ul> </div></td></tr></tbody></table> <p><b>Progesterón</b>, tudi <b>P4</b> (<b>p</b>regn-<b>4</b>-en-3,20-dion)<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> je <a href="/wiki/Steroidni_hormon" title="Steroidni hormon">steroidni hormon</a>, glavni <a href="/w/index.php?title=Progestogen&action=edit&redlink=1" class="new" title="Progestogen (stran ne obstaja)">progestogen</a>, ki ščiti <a href="/wiki/Nose%C4%8Dnost" title="Nosečnost">nosečnost</a>.<sup id="cite_ref-MS_2-0" class="reference"><a href="#cite_note-MS-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Je naravni steroid, ki ga izločajo <a href="/wiki/Jaj%C4%8Dnik" title="Jajčnik">jajčniki</a> (in sicer <a href="/w/index.php?title=Rumeno_telesce&action=edit&redlink=1" class="new" title="Rumeno telesce (stran ne obstaja)">rumeno telesce</a><sup id="cite_ref-MS_2-1" class="reference"><a href="#cite_note-MS-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>), <a href="/wiki/Posteljica" title="Posteljica">posteljica</a> in <a href="/wiki/Nadledvi%C4%8Dnica" class="mw-redirect" title="Nadledvičnica">nadledvičnica</a>. Če je v telesu dovolj <a href="/wiki/Estrogen" title="Estrogen">estrogena</a>, pride <a href="/w/index.php?title=Materni%C4%8Dna_sluznica&action=edit&redlink=1" class="new" title="Maternična sluznica (stran ne obstaja)">maternična sluznica</a> (endometrij) pod vplivom progesterona iz proliferativne v sekretorno fazo. Progesteron je potreben za povečanje sprejemljivosti endometrija za <a href="/w/index.php?title=Ugnezdenje&action=edit&redlink=1" class="new" title="Ugnezdenje (stran ne obstaja)">ugnezdenje</a> <a href="/wiki/Zarodek" title="Zarodek">zarodka</a>. Po ugnezdenju progesteron vzdržuje <a href="/wiki/Nose%C4%8Dnost" title="Nosečnost">nosečnost</a>.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Odkritje">Odkritje</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Progesteron&veaction=edit&section=1" title="Uredi razdelek: Odkritje" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Progesteron&action=edit&section=1" title="Urejanje izvorne kode razdelka: Odkritje"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Progesteron so neodvisno odkrile 4 skupine znanstvenikov.<sup id="cite_ref-pmid17747122_4-0" class="reference"><a href="#cite_note-pmid17747122-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Butenandt_1934_5-0" class="reference"><a href="#cite_note-Butenandt_1934-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Hartmann_1934_6-0" class="reference"><a href="#cite_note-Hartmann_1934-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Slotta_1934_7-0" class="reference"><a href="#cite_note-Slotta_1934-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> <a href="/w/index.php?title=Willard_Myron_Allen&action=edit&redlink=1" class="new" title="Willard Myron Allen (stran ne obstaja)">Willard Myron Allen</a> ga je leta 1933 odkril skupaj s svojim profesorjem anatomije, Georgeom Washingtonom Cornerjem. Bil je prvi, ki mu je določil <a href="/wiki/Tali%C5%A1%C4%8De" title="Tališče">tališče</a>, <a href="/wiki/Molekulska_masa" title="Molekulska masa">molekulsko maso</a> in delno molekulsko zgradbo. Ravno on ga je poimenoval progesteron, iz besedne zveze <i><b>Proge</b>stational <b>Ster</b>oidal ket<b>one</b></i> (»progestacijski steroidni keton«).<sup id="cite_ref-pmid4922128_8-0" class="reference"><a href="#cite_note-pmid4922128-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Sinteza">Sinteza</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Progesteron&veaction=edit&section=2" title="Uredi razdelek: Sinteza" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Progesteron&action=edit&section=2" title="Urejanje izvorne kode razdelka: Sinteza"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Biosinteza">Biosinteza</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Progesteron&veaction=edit&section=3" title="Uredi razdelek: Biosinteza" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Progesteron&action=edit&section=3" title="Urejanje izvorne kode razdelka: Biosinteza"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-halign-center" typeof="mw:File/Thumb"><a href="/wiki/Slika:Progesterone_biosynthesis.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Progesterone_biosynthesis.png/550px-Progesterone_biosynthesis.png" decoding="async" width="550" height="344" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Progesterone_biosynthesis.png/825px-Progesterone_biosynthesis.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/08/Progesterone_biosynthesis.png/1100px-Progesterone_biosynthesis.png 2x" data-file-width="2249" data-file-height="1408" /></a><figcaption><b>Zgoraj</b>: pretvorba holesterola (<b>1</b>) v pregnenolon (<b>3</b>) in nadalje v progesteron (<b>6</b>).<br /><b>Spodaj</b>: progesteron je pomemben za sintezo <a href="/w/index.php?title=Aldosteron&action=edit&redlink=1" class="new" title="Aldosteron (stran ne obstaja)">aldosterona</a> (<a href="/w/index.php?title=Mineralokortikoid&action=edit&redlink=1" class="new" title="Mineralokortikoid (stran ne obstaja)">mineralokortikoid</a>), <a href="/w/index.php?title=17-hidroksiprogesteron&action=edit&redlink=1" class="new" title="17-hidroksiprogesteron (stran ne obstaja)">17-hidroksiprogesteron</a> za sintezo <a href="/w/index.php?title=Kotizol&action=edit&redlink=1" class="new" title="Kotizol (stran ne obstaja)">kotizola</a> (<a href="/wiki/Glukokortikoid" title="Glukokortikoid">glukokortikoid</a>), <a href="/w/index.php?title=Androstenedione&action=edit&redlink=1" class="new" title="Androstenedione (stran ne obstaja)">androstenedione</a> pa za sintezo <a href="/w/index.php?title=Spolni_hormoni&action=edit&redlink=1" class="new" title="Spolni hormoni (stran ne obstaja)">spolnih hormonov</a>.</figcaption></figure> <p>Pri <a href="/wiki/Sesalci" title="Sesalci">sesalcih</a> se progesteron (<b><u>6</u></b>), kot tud drugi <a href="/wiki/Steroid" title="Steroid">steroidni</a> <a href="/wiki/Hormon" title="Hormon">hormoni</a>, sintetizira iz <a href="/w/index.php?title=Pregnenolon&action=edit&redlink=1" class="new" title="Pregnenolon (stran ne obstaja)">pregnenolona</a> (<b><u>3</u></b>), ki pa se tvori iz <a href="/wiki/Holesterol" title="Holesterol">holesterola</a> (<b><u>1</u></b>) (glej zgornji del slike zgoraj). </p><p>Holesterol (<b><u>1</u></b>) se dvakratno oksidira in nastane 20,22-dihidroksiholesterol (<b><u>2</u></b>), le-ta pa se nadalje oksidira ter izgubi stransko verigo na položaju C-22 in pregnenolon (<b><u>3</u></b>). Omenjeno reakcijo katalizira <a href="/w/index.php?title=Citokrom&action=edit&redlink=1" class="new" title="Citokrom (stran ne obstaja)">citokrom</a> <a href="/w/index.php?title=P450scc&action=edit&redlink=1" class="new" title="P450scc (stran ne obstaja)">P450scc</a>. Pretvorba pregnenolona v progesteron poteka v dveh korakih. V prvem se 3-<a href="/w/index.php?title=Hikdoksi&action=edit&redlink=1" class="new" title="Hikdoksi (stran ne obstaja)">hikdoksilna</a> skupina oksidira v <a href="/wiki/Keton" title="Keton">ketonsko</a> skupino (<b><u>4</u></b>), v drugem pa se dvojna vez zaradi keto-enolne <a href="/w/index.php?title=Tavtomerizacija&action=edit&redlink=1" class="new" title="Tavtomerizacija (stran ne obstaja)">tavtomerizacije</a> premesti s položaja C-5 na C-4.<sup id="cite_ref-isbn0-471-49641-3_9-0" class="reference"><a href="#cite_note-isbn0-471-49641-3-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> To reakcijo katalizira encim <a href="/w/index.php?title=3-beta-HSD&action=edit&redlink=1" class="new" title="3-beta-HSD (stran ne obstaja)">3beta-hidroksisteroid-dehidrogenaza/delta(5)-delta(4)izomeraza</a>. </p><p>Nadalje paje progesteron predhodnik za druge hormone (glej spodnji del slike na zgoraj). Iz njega nastajajo: </p> <ul><li>mineralokortikoid <a href="/w/index.php?title=Aldosteron&action=edit&redlink=1" class="new" title="Aldosteron (stran ne obstaja)">aldosteron</a>,</li> <li><a href="/wiki/Kortizol" title="Kortizol">kortizol</a> in <a href="/w/index.php?title=Androstenedion&action=edit&redlink=1" class="new" title="Androstenedion (stran ne obstaja)">androstenedion</a> po (po predhodni pretvorbi v <a href="/w/index.php?title=17-hidroksiprogesteron&action=edit&redlink=1" class="new" title="17-hidroksiprogesteron (stran ne obstaja)">17-hidroksiprogesteron</a>, drugi naravni progestogen),</li> <li>androstenedion se lahko pretvori v <a href="/wiki/Testosteron" title="Testosteron">testosteron</a>, <a href="/w/index.php?title=Estron&action=edit&redlink=1" class="new" title="Estron (stran ne obstaja)">estron</a> in <a href="/w/index.php?title=Estradiol&action=edit&redlink=1" class="new" title="Estradiol (stran ne obstaja)">estradiol</a>.</li></ul> <p>Pregenolon in progesteron lahko sintetizirajo tudi <a href="/wiki/Kvasovke" class="mw-redirect" title="Kvasovke">kvasovke</a>.<sup id="cite_ref-pmid9487528_10-0" class="reference"><a href="#cite_note-pmid9487528-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> <br clear="all" /> </p> <div class="mw-heading mw-heading3"><h3 id="Laboratorijska_sinteza">Laboratorijska sinteza</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Progesteron&veaction=edit&section=4" title="Uredi razdelek: Laboratorijska sinteza" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Progesteron&action=edit&section=4" title="Urejanje izvorne kode razdelka: Laboratorijska sinteza"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/Slika:Marker_snythesis.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/22/Marker_snythesis.png/300px-Marker_snythesis.png" decoding="async" width="300" height="137" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/22/Marker_snythesis.png/450px-Marker_snythesis.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/22/Marker_snythesis.png/600px-Marker_snythesis.png 2x" data-file-width="2753" data-file-height="1261" /></a><figcaption>Markerjeva <a href="/w/index.php?title=Polsinteza&action=edit&redlink=1" class="new" title="Polsinteza (stran ne obstaja)">polsinteza</a> progesterona iz <a href="/w/index.php?title=Diosgenin&action=edit&redlink=1" class="new" title="Diosgenin (stran ne obstaja)">diosgenina</a>.<sup id="cite_ref-Marker_1940_11-0" class="reference"><a href="#cite_note-Marker_1940-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup></figcaption></figure> <p><a href="/w/index.php?title=Russell_Earl_Marker&action=edit&redlink=1" class="new" title="Russell Earl Marker (stran ne obstaja)">Russell Marker</a> je za farmacevtsko podjetje <a href="/w/index.php?title=Parke-Davis&action=edit&redlink=1" class="new" title="Parke-Davis (stran ne obstaja)">Parke-Davis</a> leta 1940 razvil polsintezno pot za pridobivanje progesterona iz rastlinskega steroida diosgenina.<sup id="cite_ref-Marker_1940_11-1" class="reference"><a href="#cite_note-Marker_1940-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Ta polsintezni postopek je znan kot <a href="/w/index.php?title=Markerjeva_degradacija&action=edit&redlink=1" class="new" title="Markerjeva degradacija (stran ne obstaja)">Markerjeva degradacija</a>. Razvili so še polsintezne poti pridobivanja progesterona iz drugih steroidov, na primer s simultano deoksigenacijo kortizona na položajih C-17 in C-21 s pomočjo jodotrimetilsilana v <a href="/wiki/Kloroform" title="Kloroform">kloroformu</a>, pri čemer nastane 11-keto-progesteron (ketogestin), ki se nadalje reducira na položaju C-11 ter tvori progesteron.<sup id="cite_ref-pmid3815593_12-0" class="reference"><a href="#cite_note-pmid3815593-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/Slika:Progesterone_Synthesis.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9b/Progesterone_Synthesis.png/300px-Progesterone_Synthesis.png" decoding="async" width="300" height="548" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9b/Progesterone_Synthesis.png/450px-Progesterone_Synthesis.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9b/Progesterone_Synthesis.png/600px-Progesterone_Synthesis.png 2x" data-file-width="1353" data-file-height="2472" /></a><figcaption>Johnsonova popolna sinteza progesterona.<sup id="cite_ref-pmid5131151_13-0" class="reference"><a href="#cite_note-pmid5131151-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup></figcaption></figure> <p>Leta 1971 je <a href="/w/index.php?title=William_Summer_Johnson&action=edit&redlink=1" class="new" title="William Summer Johnson (stran ne obstaja)">W. S. Johnson</a> objavil popolno sintezo progesterona (glej sliko na desni).<sup id="cite_ref-pmid5131151_13-1" class="reference"><a href="#cite_note-pmid5131151-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> Sinteza se začne z reakcijo med <a href="/w/index.php?title=Fosfonijev_sol&action=edit&redlink=1" class="new" title="Fosfonijev sol (stran ne obstaja)">fosfonijevo soljo</a> <b><u>7</u></b> in <a href="/w/index.php?title=Fenillitij&action=edit&redlink=1" class="new" title="Fenillitij (stran ne obstaja)">fenillitijem</a>, pri čemer nastane <a href="/w/index.php?title=Fosfonijev_ilid&action=edit&redlink=1" class="new" title="Fosfonijev ilid (stran ne obstaja)">fosfonijev ilid</a> <b><u>8</u></b>. Ilid <b><u>8</u></b> daje ob reakciji z <a href="/wiki/Aldehid" title="Aldehid">aldehidom</a> <a href="/wiki/Alken" title="Alken">alken</a> <b><u>9</u></b>. <a href="/w/index.php?title=Ketal&action=edit&redlink=1" class="new" title="Ketal (stran ne obstaja)">Ketalna</a> <a href="/w/index.php?title=Za%C5%A1%C4%8Ditna_skupina&action=edit&redlink=1" class="new" title="Zaščitna skupina (stran ne obstaja)">zaščitna skupina</a> alkena <b><u>9</u></b> se <a href="/wiki/Hidroliza" title="Hidroliza">hidrolizira</a> in nastane diketon <b><u>10</u></b>, le-ta pa se ciklizira v ciklopentenon <b><u>11</u></b>. Ketonski derivat <b><u>11</u></b> reagira z metillitijem in nastane terciarni alkohol <b><u>12</u></b>, ki nadalje v prisotnosti kisline daje terciarni kation <b><u>13</u></b>. Ključna stopnja v sintezi je π-kationska ciklizacija derivata <b><u>13</u></b>, pri čemer se simultano tvorijo obroči B, C in D ter nastane <b><u>14</u></b>. Ta korak oponaša kationsko ciklizacijo v biosintezi steroidov in ga zato imenujejo <i>biomimetični korak</i>. V naslednjem koraku se enolni <a href="/w/index.php?title=Ortoester&action=edit&redlink=1" class="new" title="Ortoester (stran ne obstaja)">ortoester</a> hidrolizira in nastane keton <b><u>15</u></b>. Ciklopentenski obroč A se nato odpre s pomočjo oksidacije z ozonom in nastane <b><u>16</u></b>. Na koncu na diketonu <b><u>17</u></b> poteče v prisotnosti vodnega <a href="/wiki/Kalijev_hidroksid" title="Kalijev hidroksid">kalijevega hidroksida</a> intramolekulska <a href="/w/index.php?title=Aldolna_kondenzacija&action=edit&redlink=1" class="new" title="Aldolna kondenzacija (stran ne obstaja)">aldolna kondenzacija</a> in nastane progesteron.<sup id="cite_ref-pmid5131151_13-2" class="reference"><a href="#cite_note-pmid5131151-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Pomanjkanje">Pomanjkanje</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Progesteron&veaction=edit&section=5" title="Uredi razdelek: Pomanjkanje" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Progesteron&action=edit&section=5" title="Urejanje izvorne kode razdelka: Pomanjkanje"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Medtem ko menopavza običajno ne nastopi pred 50. letom, pa se večini žensk po 30. letu starosti prične rušiti hormonsko ravnovesje. Zniževanje ravni progesterona počasi povzroča spremebe, dokler do 50. leta starosti počasi ne upade za kar 75 %. Naravni progesteron v telesu uravnava količine odvečnega estrogena, ki so najpogostejši razlog za <a href="/wiki/Rak_dojke" title="Rak dojke">raka dojke</a>. Progesteron se prav tako v telesu lahko obnaša kot nevtralni hormon saj ga telo glede na potrebe lahko spremeni tako v estrogen ali testosteron – odvisno od potrebe.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedija:Navajanje_virov" title="Wikipedija:Navajanje virov"><span title="Ta trditev potrebuje sklice na zanesljive vire. (mesec ni naveden )">navedi vir</span></a></i>]</sup> </p> <div class="mw-heading mw-heading3"><h3 id="Simptomi_pomanjkanja_progesterona">Simptomi pomanjkanja progesterona</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Progesteron&veaction=edit&section=6" title="Uredi razdelek: Simptomi pomanjkanja progesterona" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Progesteron&action=edit&section=6" title="Urejanje izvorne kode razdelka: Simptomi pomanjkanja progesterona"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Progesteron se v telesu ženske že po 30. letu starosti znatno zmanjšuje. Zmanjšanje le-tega pa povzroča presežke estrogena, ki deluje na telo uničujoče. Vse več žensk prav zaradi tega izgublja lase, pojavljajo se jim dlake po telesu, <a href="/w/index.php?title=Kostna_masa&action=edit&redlink=1" class="new" title="Kostna masa (stran ne obstaja)">kostna masa</a> se manjša, hormonsko ravnotežje se podira, povečuje se težava z <a href="/wiki/Neplodnost" title="Neplodnost">neplodnostjo</a>, povečuje se količina maščobnega tkiva <sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedija:Navajanje_virov" title="Wikipedija:Navajanje virov"><span title="Ta trditev potrebuje sklice na zanesljive vire. (mesec ni naveden )">navedi vir</span></a></i>]</sup> </p> <div class="mw-heading mw-heading2"><h2 id="Uporaba">Uporaba</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Progesteron&veaction=edit&section=7" title="Uredi razdelek: Uporaba" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Progesteron&action=edit&section=7" title="Urejanje izvorne kode razdelka: Uporaba"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Progesteron in njegovi analogi se uporabljajo za različne medicinske namene, tako za akutne situacije kot pri dolgotrajnem pomanjkanju naravnega progesterona. Ker ima progesteron po zaužitju slabo <a href="/wiki/Biolo%C5%A1ka_razpolo%C5%BEljivost" class="mw-redirect" title="Biološka razpoložljivost">biološko razpoložljivost</a>, so razvili številne sintetične <a href="/w/index.php?title=Progestin&action=edit&redlink=1" class="new" title="Progestin (stran ne obstaja)">progestine</a> z boljšo biološko razpoložljivostjo po peroralni uporabi, še preden so prišla na tržišče <a href="/wiki/Farmacevtska_oblika" title="Farmacevtska oblika">farmacevtske oblike</a> s samim progesteronom.<sup id="cite_ref-pmid19434889_14-0" class="reference"><a href="#cite_note-pmid19434889-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> Za klinično uporabo je sam progesteron postal primeren šele v mikronizirani obliki, ki je zagotovila boljšo <a href="/wiki/Absorpcija" title="Absorpcija">absorpcijo</a> po peroralni uporabi, boljšo biološko uporabnost in podaljšan čas inaktivacije.<sup id="cite_ref-Vrabic_15-0" class="reference"><a href="#cite_note-Vrabic-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p><p>Uporablja se pri hormonskem zdravljenju, bistvo katerega je sicer dodajanje <a href="/wiki/Estrogen" title="Estrogen">estrogena</a> ženskam za lajšnje <a href="/w/index.php?title=Klimakterij&action=edit&redlink=1" class="new" title="Klimakterij (stran ne obstaja)">klimakteričnih</a> težav. Progestogeni (med njimi progesteron) so dodani le za preprečevanje hiperstimulacije maternične sluznice zaradi estrogena, ki lahko vodi v razvoj endometrijskega <a href="/w/index.php?title=Karcinom&action=edit&redlink=1" class="new" title="Karcinom (stran ne obstaja)">karcinoma</a>.<sup id="cite_ref-Vrabic_15-1" class="reference"><a href="#cite_note-Vrabic-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p><p>Peroralno se uporablja tudi za induciranje menstrualnega cikla, zdravljenje nenormalnih krvavitev iz maternice zaradi hormonskega neravnovesja in pri hudih simptomih <a href="/w/index.php?title=Predmenstrualni_sindrom&action=edit&redlink=1" class="new" title="Predmenstrualni sindrom (stran ne obstaja)">predmenstrualnega sindroma</a>.<sup id="cite_ref-webmd_16-0" class="reference"><a href="#cite_note-webmd-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p><p>Topično vaginalno se uporablja v obliki kreme ali gela pri nadomestnem hormonskem zdravljenju, zdravljenju težav med menopavzo (na primer vročinskih oblivov), pri preprečevanju <a href="/wiki/Alergija" title="Alergija">alergij</a>, ki so povezane s hormoni, zatrdelih dojkah, zmanjšani <a href="/w/index.php?title=Spolna_sla&action=edit&redlink=1" class="new" title="Spolna sla (stran ne obstaja)">spolni sli</a>, <a href="/wiki/Depresija" class="mw-disambig" title="Depresija">depresiji</a>, <a href="/wiki/Neplodnost" title="Neplodnost">neplodnosti</a>, <a href="/wiki/Osteoporoza" title="Osteoporoza">osteoporozi</a>, simptomih predmenstrualnega sindroma ...<sup id="cite_ref-webmd_16-1" class="reference"><a href="#cite_note-webmd-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p><p>Dokazano je, da progesteron znižuje izločanje beljakovin, ki sodelujejo pri nastanku <a href="/w/index.php?title=Popadek&action=edit&redlink=1" class="new" title="Popadek (stran ne obstaja)">popadkov</a>. Zato se uporablja za preprečevanje <a href="/w/index.php?title=Spontani_splav&action=edit&redlink=1" class="new" title="Spontani splav (stran ne obstaja)">spontanega splava</a> ali prezgodnjega <a href="/wiki/Porod" title="Porod">poroda</a>. Vaginalno se uporablja na primer pri nosečnicah s kratkim materničnim vratom, ki imajo višje tveganje za prezgodnji porod.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Sklici">Sklici</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Progesteron&veaction=edit&section=8" title="Uredi razdelek: Sklici" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Progesteron&action=edit&section=8" title="Urejanje izvorne kode razdelka: Sklici"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="reflist" style="list-style-type: decimal;"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r5980307">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"»""«""›""‹"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free a,.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited a,.mw-parser-output .id-lock-registration a,.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription a,.mw-parser-output .citation .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:#d33}.mw-parser-output .cs1-visible-error{color:#d33}.mw-parser-output .cs1-maint{display:none;color:#3a3;margin-left:0.3em}.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.hmdb.ca/metabolites/HMDB00920">»Metabocard for Hydroxyprogesterone«</a>. Human Metabolome Database<span class="reference-accessdate">. Pridobljeno 31. julija 2013</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=neznano&rft.btitle=Metabocard+for+Hydroxyprogesterone&rft.pub=Human+Metabolome+Database&rft_id=http%3A%2F%2Fwww.hmdb.ca%2Fmetabolites%2FHMDB00920&rfr_id=info%3Asid%2Fsl.wikipedia.org%3AProgesteron" class="Z3988"></span></span> </li> <li id="cite_note-MS-2"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-MS_2-0">2,0</a></sup> <sup><a href="#cite_ref-MS_2-1">2,1</a></sup></span> <span class="reference-text"><a rel="nofollow" class="external free" href="http://lsm1.amebis.si/lsmeds/novPogoj.aspx?pPogoj=progesteron">http://lsm1.amebis.si/lsmeds/novPogoj.aspx?pPogoj=progesteron</a><sup class="noprint Inline-Template"><span style="white-space: nowrap;">[<i><a href="/wiki/Wikipedija:Mrtva_povezava" title="Wikipedija:Mrtva povezava"><span title=" Mrtva povezava, označena mesec ni naveden">mrtva povezava</span></a></i>]</span></sup>, Slovenski medicinski e-slovar, vpogled: 8. 9. 2013.</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text">Razinger B. Kreme z bioidentičnim progesteronom. Farmakon, številka 42, avgust 2013.</span> </li> <li id="cite_note-pmid17747122-4"><span class="mw-cite-backlink"><a href="#cite_ref-pmid17747122_4-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5980307"><cite id="CITEREFAllen_WM1935" class="citation journal cs1">Allen WM (1935). »The isolation of crystalline progestin«. <i>Science</i>. <b>82</b> (2118): 89–93. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.082.2118.89">10.1126/science.082.2118.89</a>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17747122">17747122</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=%C4%8Dlanek&rft.jtitle=Science&rft.atitle=The+isolation+of+crystalline+progestin&rft.volume=82&rft.issue=2118&rft.pages=89-93&rft.date=1935&rft_id=info%3Adoi%2F10.1126%2Fscience.082.2118.89&rft_id=info%3Apmid%2F17747122&rft.au=Allen+WM&rfr_id=info%3Asid%2Fsl.wikipedia.org%3AProgesteron" class="Z3988"></span></span> </li> <li id="cite_note-Butenandt_1934-5"><span class="mw-cite-backlink"><a href="#cite_ref-Butenandt_1934_5-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5980307"><cite id="CITEREFButenandt_AWestphal_U1934" class="citation journal cs1">Butenandt A; Westphal U (1934). »Zur Isolierung und Charakterisierung des Corpusluteum-Hormons«. <i>Berichte Deu0tsche chemische Gesellschaft</i>. <b>67</b> (8): 1440–1442. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fcber.19340670831">10.1002/cber.19340670831</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=%C4%8Dlanek&rft.jtitle=Berichte+Deu0tsche+chemische+Gesellschaft&rft.atitle=Zur+Isolierung+und+Charakterisierung+des+Corpusluteum-Hormons&rft.volume=67&rft.issue=8&rft.pages=1440-1442&rft.date=1934&rft_id=info%3Adoi%2F10.1002%2Fcber.19340670831&rft.au=Butenandt+A&rft.au=Westphal+U&rfr_id=info%3Asid%2Fsl.wikipedia.org%3AProgesteron" class="Z3988"></span></span> </li> <li id="cite_note-Hartmann_1934-6"><span class="mw-cite-backlink"><a href="#cite_ref-Hartmann_1934_6-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5980307"><cite id="CITEREFHartmann_MWettstein_A1934" class="citation journal cs1">Hartmann M; Wettstein A (1934). »Ein krystallisiertes Hormon aus Corpus luteum«. <i>Helvetica Chimica Acta</i>. <b>17</b>: 878–882. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fhlca.193401701111">10.1002/hlca.193401701111</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=%C4%8Dlanek&rft.jtitle=Helvetica+Chimica+Acta&rft.atitle=Ein+krystallisiertes+Hormon+aus+Corpus+luteum&rft.volume=17&rft.pages=878-882&rft.date=1934&rft_id=info%3Adoi%2F10.1002%2Fhlca.193401701111&rft.au=Hartmann+M&rft.au=Wettstein+A&rfr_id=info%3Asid%2Fsl.wikipedia.org%3AProgesteron" class="Z3988"></span></span> </li> <li id="cite_note-Slotta_1934-7"><span class="mw-cite-backlink"><a href="#cite_ref-Slotta_1934_7-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5980307"><cite id="CITEREFSlotta_KHRuschig_HFels_E1934" class="citation journal cs1"><a href="/w/index.php?title=Karl_Slotta&action=edit&redlink=1" class="new" title="Karl Slotta (stran ne obstaja)">Slotta KH</a>; Ruschig H; Fels E (1934). »Reindarstellung der Hormone aus dem Corpusluteum«. <i>Berichte Deutsche chemische Gesellschaft</i>. <b>67</b> (7): 1270–1273. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fcber.19340670729">10.1002/cber.19340670729</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=%C4%8Dlanek&rft.jtitle=Berichte+Deutsche+chemische+Gesellschaft&rft.atitle=Reindarstellung+der+Hormone+aus+dem+Corpusluteum&rft.volume=67&rft.issue=7&rft.pages=1270-1273&rft.date=1934&rft_id=info%3Adoi%2F10.1002%2Fcber.19340670729&rft.au=Slotta+KH&rft.au=Ruschig+H&rft.au=Fels+E&rfr_id=info%3Asid%2Fsl.wikipedia.org%3AProgesteron" class="Z3988"></span></span> </li> <li id="cite_note-pmid4922128-8"><span class="mw-cite-backlink"><a href="#cite_ref-pmid4922128_8-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5980307"><cite id="CITEREFAllen_WM1970" class="citation journal cs1">Allen WM (1970). <a rel="nofollow" class="external text" href="https://archive.org/details/sim_southern-medical-journal_1970-10_63_10/page/1151">»Progesterone: how did the name originate?«</a>. <i>South. Med. J</i>. <b>63</b> (10): 1151–5. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2F00007611-197010000-00012">10.1097/00007611-197010000-00012</a>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/4922128">4922128</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=%C4%8Dlanek&rft.jtitle=South.+Med.+J.&rft.atitle=Progesterone%3A+how+did+the+name+originate%3F&rft.volume=63&rft.issue=10&rft.pages=1151-5&rft.date=1970&rft_id=info%3Adoi%2F10.1097%2F00007611-197010000-00012&rft_id=info%3Apmid%2F4922128&rft.au=Allen+WM&rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_southern-medical-journal_1970-10_63_10%2Fpage%2F1151&rfr_id=info%3Asid%2Fsl.wikipedia.org%3AProgesteron" class="Z3988"></span></span> </li> <li id="cite_note-isbn0-471-49641-3-9"><span class="mw-cite-backlink"><a href="#cite_ref-isbn0-471-49641-3_9-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5980307"><cite id="CITEREFDewick,_Paul_M.2002" class="citation book cs1">Dewick, Paul M. (2002). <a rel="nofollow" class="external text" href="https://archive.org/details/medicinalnatural00dewi_996"><i>Medicinal natural products: a biosynthetic approach</i></a>. New York: Wiley. str. <a rel="nofollow" class="external text" href="https://archive.org/details/medicinalnatural00dewi_996/page/n273">244</a>. <a href="/wiki/ISBN_(identifikator)" class="mw-redirect" title="ISBN (identifikator)">ISBN</a> <a href="/wiki/Posebno:ViriKnjig/0-471-49641-3" title="Posebno:ViriKnjig/0-471-49641-3"><bdi>0-471-49641-3</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=knjiga&rft.btitle=Medicinal+natural+products%3A+a+biosynthetic+approach&rft.place=New+York&rft.pages=244&rft.pub=Wiley&rft.date=2002&rft.isbn=0-471-49641-3&rft.au=Dewick%2C+Paul+M.&rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fmedicinalnatural00dewi_996&rfr_id=info%3Asid%2Fsl.wikipedia.org%3AProgesteron" class="Z3988"></span></span> </li> <li id="cite_note-pmid9487528-10"><span class="mw-cite-backlink"><a href="#cite_ref-pmid9487528_10-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5980307"><cite id="CITEREFDuport_CSpagnoli_RDegryse_EPompon_D1998" class="citation journal cs1">Duport C; Spagnoli R; Degryse E; Pompon D (Februar 1998). <a rel="nofollow" class="external text" href="https://archive.org/details/sim_nature-biotechnology_1998-02_16_2/page/186">»Self-sufficient biosynthesis of pregnenolone and progesterone in engineered yeast«</a>. <i>Nat. Biotechnol</i>. <b>16</b> (2): 186–189. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnbt0298-186">10.1038/nbt0298-186</a>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9487528">9487528</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=%C4%8Dlanek&rft.jtitle=Nat.+Biotechnol.&rft.atitle=Self-sufficient+biosynthesis+of+pregnenolone+and+progesterone+in+engineered+yeast&rft.volume=16&rft.issue=2&rft.pages=186-189&rft.date=1998-02&rft_id=info%3Adoi%2F10.1038%2Fnbt0298-186&rft_id=info%3Apmid%2F9487528&rft.au=Duport+C&rft.au=Spagnoli+R&rft.au=Degryse+E&rft.au=Pompon+D&rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_nature-biotechnology_1998-02_16_2%2Fpage%2F186&rfr_id=info%3Asid%2Fsl.wikipedia.org%3AProgesteron" class="Z3988"></span></span> </li> <li id="cite_note-Marker_1940-11"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Marker_1940_11-0">11,0</a></sup> <sup><a href="#cite_ref-Marker_1940_11-1">11,1</a></sup></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5980307"><cite id="CITEREFMarker_REKrueger_J1940" class="citation journal cs1">Marker RE; Krueger J (1940). »Sterols. CXII. Sapogenins. XLI. The Preparation of Trillin and its Conversion to Progesterone«. <i>J. Am. Chem. Soc</i>. <b>62</b> (12): 3349–3350. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1021%2Fja01869a023">10.1021/ja01869a023</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=%C4%8Dlanek&rft.jtitle=J.+Am.+Chem.+Soc.&rft.atitle=Sterols.+CXII.+Sapogenins.+XLI.+The+Preparation+of+Trillin+and+its+Conversion+to+Progesterone&rft.volume=62&rft.issue=12&rft.pages=3349-3350&rft.date=1940&rft_id=info%3Adoi%2F10.1021%2Fja01869a023&rft.au=Marker+RE&rft.au=Krueger+J&rfr_id=info%3Asid%2Fsl.wikipedia.org%3AProgesteron" class="Z3988"></span></span> </li> <li id="cite_note-pmid3815593-12"><span class="mw-cite-backlink"><a href="#cite_ref-pmid3815593_12-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5980307"><cite id="CITEREFNumazawa_MNagaoka_MKunitama_Y1986" class="citation journal cs1">Numazawa M; Nagaoka M; Kunitama Y (1986). <a rel="nofollow" class="external text" href="https://archive.today/20121209004311/http://www.journalarchive.jst.go.jp/english/jnlabstract_en.php?cdjournal=cpb1958&cdvol=34&noissue=9&startpage=3722">»Regiospecific deoxygenation of the dihydroxyacetone moiety at C-17 of corticoid steroids with iodotrimethylsilane«</a>. <i>Chem. Pharm. Bull</i>. <b>34</b> (9): 3722–3726. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1248%2Fcpb.34.3722">10.1248/cpb.34.3722</a>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3815593">3815593</a>. Arhivirano iz <a rel="nofollow" class="external text" href="http://www.journalarchive.jst.go.jp/english/jnlabstract_en.php?cdjournal=cpb1958&cdvol=34&noissue=9&startpage=3722">prvotnega spletišča</a> dne 9. decembra 2012<span class="reference-accessdate">. Pridobljeno 8. septembra 2013</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=%C4%8Dlanek&rft.jtitle=Chem.+Pharm.+Bull.&rft.atitle=Regiospecific+deoxygenation+of+the+dihydroxyacetone+moiety+at+C-17+of+corticoid+steroids+with+iodotrimethylsilane&rft.volume=34&rft.issue=9&rft.pages=3722-3726&rft.date=1986&rft_id=info%3Adoi%2F10.1248%2Fcpb.34.3722&rft_id=info%3Apmid%2F3815593&rft.au=Numazawa+M&rft.au=Nagaoka+M&rft.au=Kunitama+Y&rft_id=http%3A%2F%2Fwww.journalarchive.jst.go.jp%2Fenglish%2Fjnlabstract_en.php%3Fcdjournal%3Dcpb1958%26cdvol%3D34%26noissue%3D9%26startpage%3D3722&rfr_id=info%3Asid%2Fsl.wikipedia.org%3AProgesteron" class="Z3988"></span></span> </li> <li id="cite_note-pmid5131151-13"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-pmid5131151_13-0">13,0</a></sup> <sup><a href="#cite_ref-pmid5131151_13-1">13,1</a></sup> <sup><a href="#cite_ref-pmid5131151_13-2">13,2</a></sup></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5980307"><cite id="CITEREFJohnson_WSGravestock_MBMcCarry_BE1971" class="citation journal cs1">Johnson WS; Gravestock MB; McCarry BE (1971). »Acetylenic bond participation in biogenetic-like olefinic cyclizations. II. Synthesis of dl-progesterone«. <i>J. Am. Chem. Soc</i>. <b>93</b> (17): 4332–4334. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1021%2Fja00746a062">10.1021/ja00746a062</a>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/5131151">5131151</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=%C4%8Dlanek&rft.jtitle=J.+Am.+Chem.+Soc.&rft.atitle=Acetylenic+bond+participation+in+biogenetic-like+olefinic+cyclizations.+II.+Synthesis+of+dl-progesterone&rft.volume=93&rft.issue=17&rft.pages=4332-4334&rft.date=1971&rft_id=info%3Adoi%2F10.1021%2Fja00746a062&rft_id=info%3Apmid%2F5131151&rft.au=Johnson+WS&rft.au=Gravestock+MB&rft.au=McCarry+BE&rfr_id=info%3Asid%2Fsl.wikipedia.org%3AProgesteron" class="Z3988"></span></span> </li> <li id="cite_note-pmid19434889-14"><span class="mw-cite-backlink"><a href="#cite_ref-pmid19434889_14-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5980307"><cite id="CITEREFSchindler_AECampagnoli_CDruckmann_RHuber_J2008" class="citation journal cs1">Schindler AE; Campagnoli C; Druckmann R; Huber J; Pasqualini JR; Schweppe KW; Thijssen JH (2008). <a rel="nofollow" class="external text" href="http://www1.elsevier.com/homepage/sab/womenshealth/doc/journals/maturitas_si/2.pdf">»Classification and pharmacology of progestins«</a> <span class="cs1-format">(PDF)</span>. <i>Maturitas</i>. <b>61</b> (1–2): 171–80. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.maturitas.2003.09.014">10.1016/j.maturitas.2003.09.014</a>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19434889">19434889</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=%C4%8Dlanek&rft.jtitle=Maturitas&rft.atitle=Classification+and+pharmacology+of+progestins&rft.volume=61&rft.issue=1%E2%80%932&rft.pages=171-80&rft.date=2008&rft_id=info%3Adoi%2F10.1016%2Fj.maturitas.2003.09.014&rft_id=info%3Apmid%2F19434889&rft.au=Schindler+AE&rft.au=Campagnoli+C&rft.au=Druckmann+R&rft.au=Huber+J&rft.au=Pasqualini+JR&rft.au=Schweppe+KW&rft.au=Thijssen+JH&rft_id=http%3A%2F%2Fwww1.elsevier.com%2Fhomepage%2Fsab%2Fwomenshealth%2Fdoc%2Fjournals%2Fmaturitas_si%2F2.pdf&rfr_id=info%3Asid%2Fsl.wikipedia.org%3AProgesteron" class="Z3988"></span><sup class="noprint Inline-Template"><span style="white-space: nowrap;">[<i><a href="/wiki/Wikipedija:Mrtva_povezava" title="Wikipedija:Mrtva povezava"><span title=" Mrtva povezava, označena mesec ni naveden">mrtva povezava</span></a></i>]</span></sup></span> </li> <li id="cite_note-Vrabic-15"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Vrabic_15-0">15,0</a></sup> <sup><a href="#cite_ref-Vrabic_15-1">15,1</a></sup></span> <span class="reference-text">Vrabič Dežman L. Bioidentični hormoni. Farmakon, številka 42, avgust 2013.</span> </li> <li id="cite_note-webmd-16"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-webmd_16-0">16,0</a></sup> <sup><a href="#cite_ref-webmd_16-1">16,1</a></sup></span> <span class="reference-text"><a rel="nofollow" class="external free" href="http://www.webmd.com/vitamins-supplements/ingredientmono-760-progesterone.aspx?activeIngredientId=760&activeIngredientName=progesterone">http://www.webmd.com/vitamins-supplements/ingredientmono-760-progesterone.aspx?activeIngredientId=760&activeIngredientName=progesterone</a>, vpogled: 8. 9. 2013.</span> </li> <li id="cite_note-17"><span class="mw-cite-backlink"><a href="#cite_ref-17">↑</a></span> <span class="reference-text">Mujezinović, Faris (2009). Kratek maternični vrat - kaj pa zdaj?. Zdravniški vestnik, letnik 78, številka 1, str. I-85-I-89.</span> </li> </ol></div></div> <div role="navigation" class="navbox" aria-label="Navbox" style="padding:3px"><table class="nowraplinks hlist navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Wikipedija:Normativna_kontrola" title="Wikipedija:Normativna kontrola">Normativna kontrola: Narodne knjižnice</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q26963#identifiers" title="Uredite to na Wikipodatkih"><img alt="Uredite to na Wikipodatkih" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></th><td class="navbox-list navbox-odd" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><span class="uid"><a rel="nofollow" class="external text" href="https://catalogue.bnf.fr/ark:/12148/cb119521208">Francija</a> <a rel="nofollow" class="external text" href="https://data.bnf.fr/ark:/12148/cb119521208">(data)</a></span></li> <li><span class="uid"><a rel="nofollow" class="external text" href="https://d-nb.info/gnd/4047389-2">Nemčija</a></span></li> <li><span class="uid"><a rel="nofollow" class="external text" href="http://uli.nli.org.il/F/?func=find-b&local_base=NLX10&find_code=UID&request=987007538694405171">Izrael</a></span></li> <li><span class="uid"><a rel="nofollow" class="external text" href="https://id.loc.gov/authorities/subjects/sh85107294">ZDA</a></span></li> <li><span class="uid"><a rel="nofollow" class="external text" href="https://aleph.nkp.cz/F/?func=find-c&local_base=aut&ccl_term=ica=ph425911&CON_LNG=ENG">Češka republika</a></span></li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; 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