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src="https://www.lexeotx.com/wp-content/uploads/2021/12/bg_top_Lexeo-Therapeutics-CNS-programs.jpg" class="attachment-full size-full" alt="" decoding="async" fetchpriority="high" srcset="https://www.lexeotx.com/wp-content/uploads/2021/12/bg_top_Lexeo-Therapeutics-CNS-programs.jpg 1427w, https://www.lexeotx.com/wp-content/uploads/2021/12/bg_top_Lexeo-Therapeutics-CNS-programs-300x300.jpg 300w, https://www.lexeotx.com/wp-content/uploads/2021/12/bg_top_Lexeo-Therapeutics-CNS-programs-1024x1024.jpg 1024w, https://www.lexeotx.com/wp-content/uploads/2021/12/bg_top_Lexeo-Therapeutics-CNS-programs-150x150.jpg 150w, https://www.lexeotx.com/wp-content/uploads/2021/12/bg_top_Lexeo-Therapeutics-CNS-programs-768x768.jpg 768w" sizes="(max-width: 1427px) 100vw, 1427px" /> </div> </div> <svg class="intro__svg intro__svg-right js-intro__svg-right" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" viewBox="0 0 690 969" shape-rendering="geometricPrecision" text-rendering="geometricPrecision"> <g> <path class="path-1" stroke-dasharray="10000" stroke-dashoffset="10000" d="M649,0.999969L285.502,509" fill="none" stroke="rgb(110,173,227)" stroke-width="2"/> </g> <g> <path class="path-2" stroke-dasharray="10000" stroke-dashoffset="10000" d="M678.488,7L1,967" fill="none" stroke="rgb(176,194,199)" stroke-width="2"/> </g> <g > <path class="path-3" stroke-dasharray="10000" stroke-dashoffset="10000" d="M180.324,967L473.5,552.488" fill="none" stroke="rgb(176,194,199)" stroke-width="2"/> </g> <path class="path-4" stroke-dasharray="10000" stroke-dashoffset="10000" d="M516.464,878.567L687.995,878.567L484.143,570.992L394.152,697.827L516.464,878.567Z" fill="none" stroke="rgb(176,194,199)" stroke-width="2" /> <path class="opacity-2" d="M284.094,533.999L372.817,407.165L253.041,225.156L72.4258,225.156L284.094,533.999Z" fill="rgb(110,173,227)" stroke="rgb(110,173,227)" stroke-width="2" /> <path class="path-5" stroke-dasharray="10000" stroke-dashoffset="10000" d="M207,967L382,717.5L546,967" fill="none" stroke="rgb(211,42,98)" stroke-width="4" /> <path class="path-6" stroke-dasharray="10000" stroke-dashoffset="10000" d="M95.0019,226L285.5,509L364.926,398" fill="none" stroke="rgb(255,255,255)" stroke-width="2" /> </svg> </div> </section> <main class="program-content"> <div class="container"> <p>LEXEO aims to apply the transformational science of gene therapy to address some of the most devastating central nervous system diseases affecting both rare and prevalent patient populations. We are developing a pipeline of CNS focused gene therapies that includes a portfolio of approaches to treat the genetics underlying Alzheimer鈥檚 disease.</p> <p></p> <picture> <source media="(max-width: 767px)" srcset="https://www.lexeotx.com/wp-content/uploads/2021/12/Lexeo-TX-CNS-programs-mobile.png"> <img src="https://www.lexeotx.com/wp-content/uploads/2022/01/Lexeo-TX-CNS-programs.png" alt=""> </picture> </div> </main>  <section class="programs"> <div class="container"> <h2></h2> <div class="programs__list"> <div class="programs__list-item"> <h3 class="programs__list-item-title" style="color:"><span style="color: #1c4c9c;">LX1001</span> / <span style="color: #6182b7;">LX1020</span> / <span style="color: #6eade3;">LX1021</span> </h3> <h4 class="programs__list-item-subtitle">Alzheimer鈥檚</h4> <p>Our current gene therapy programs under development for the treatment of Alzheimer鈥檚 disease are: <ul> <li> LX1001: a gene therapy candidate that is designed to express the protective APOE2 protein </li> in the CNS of APOE4 homozygous patients. <li> LX1021: a gene therapy candidate that is designed to express the Christchurch-modified</li> APOE2 protein in the CNS of APOE4 homozygous patients. The Christchurch mutation has been observed to protect patients against Alzheimer鈥檚 disease even in the presence of significant amyloid pathology. <li> LX1020: a gene therapy candidate that is designed to express the protective APOE2 protein in the CNS of APOE4 homozygous patients, while concurrently delivering miRNA to suppress the expression of the APOE4 protein.</li> </ul> We are developing LX1001 to target homozygous APOE4-associated Alzheimer鈥檚 disease patients, the highest risk population to develop Alzheimer鈥檚 disease and the sub-group we believe will be the most likely to demonstrate a potential treatment effect from APOE2-based gene therapy. </p> <a href="https://www.lexeotx.com/programs/cns-programs/alzheimers/" class="programs__list-item-more button">learn more</a> </div> </div> </div> </section>  </div>  <footer class="main-footer"> <div class="main-footer__holder"> <div class="container"> <div class="main-footer__top"> <div class="main-footer__info"> <a href="/" 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