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Barbituraat - Wikipedia

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Dit is echter niet verplicht."><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>Account aanmaken</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Speciaal:Aanmelden&amp;returnto=Barbituraat" title="U wordt van harte uitgenodigd om aan te melden, maar dit is niet verplicht [o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>Aanmelden</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> Pagina&#039;s voor uitgelogde redacteuren <a href="/wiki/Help:Inleiding" aria-label="Meer leren over bewerken"><span>meer lezen</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Speciaal:MijnBijdragen" title="Bijdragen IP-adres [y]" accesskey="y"><span>Bijdragen</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Speciaal:MijnOverleg" title="Overlegpagina van de anonieme gebruiker van dit IP-adres [n]" accesskey="n"><span>Overleg</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"><!-- CentralNotice --></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Site"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Barbituraat</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Ga naar een artikel in een andere taal. Beschikbaar in 57 talen" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-57" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">57 talen</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-af mw-list-item"><a href="https://af.wikipedia.org/wiki/Barbituraat" title="Barbituraat – Afrikaans" lang="af" hreflang="af" data-title="Barbituraat" data-language-autonym="Afrikaans" data-language-local-name="Afrikaans" class="interlanguage-link-target"><span>Afrikaans</span></a></li><li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A8%D8%A7%D8%B1%D8%A8%D8%AA%D9%8A%D9%88%D8%B1%D8%A7%D8%AA" title="باربتيورات – Arabisch" lang="ar" hreflang="ar" data-title="باربتيورات" data-language-autonym="العربية" data-language-local-name="Arabisch" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-arz mw-list-item"><a href="https://arz.wikipedia.org/wiki/%D8%A8%D8%A7%D8%B1%D8%A8%D9%8A%D8%AA%D9%8A%D9%88%D8%B1%D8%A7%D8%AA" title="باربيتيورات – Egyptisch Arabisch" lang="arz" hreflang="arz" data-title="باربيتيورات" data-language-autonym="مصرى" data-language-local-name="Egyptisch Arabisch" class="interlanguage-link-target"><span>مصرى</span></a></li><li class="interlanguage-link interwiki-az mw-list-item"><a href="https://az.wikipedia.org/wiki/Barbituratlar" title="Barbituratlar – Azerbeidzjaans" lang="az" hreflang="az" data-title="Barbituratlar" data-language-autonym="Azərbaycanca" data-language-local-name="Azerbeidzjaans" class="interlanguage-link-target"><span>Azərbaycanca</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%91%D0%B0%D1%80%D0%B1%D0%B8%D1%82%D1%83%D1%80%D0%B0%D1%82" title="Барбитурат – Bulgaars" lang="bg" hreflang="bg" data-title="Барбитурат" data-language-autonym="Български" data-language-local-name="Bulgaars" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-bn mw-list-item"><a href="https://bn.wikipedia.org/wiki/%E0%A6%AC%E0%A6%BE%E0%A6%B0%E0%A6%AC%E0%A6%BF%E0%A6%9A%E0%A7%81%E0%A6%B0%E0%A7%87%E0%A6%9F" title="বারবিচুরেট – Bengaals" lang="bn" hreflang="bn" data-title="বারবিচুরেট" data-language-autonym="বাংলা" data-language-local-name="Bengaals" class="interlanguage-link-target"><span>বাংলা</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Barbit%C3%BAric" title="Barbitúric – Catalaans" lang="ca" hreflang="ca" data-title="Barbitúric" data-language-autonym="Català" data-language-local-name="Catalaans" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Barbitur%C3%A1ty" title="Barbituráty – Tsjechisch" lang="cs" hreflang="cs" data-title="Barbituráty" data-language-autonym="Čeština" data-language-local-name="Tsjechisch" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Barbiturat" title="Barbiturat – Deens" lang="da" hreflang="da" data-title="Barbiturat" data-language-autonym="Dansk" data-language-local-name="Deens" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Barbiturate" title="Barbiturate – Duits" lang="de" hreflang="de" data-title="Barbiturate" data-language-autonym="Deutsch" data-language-local-name="Duits" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%92%CE%B1%CF%81%CE%B2%CE%B9%CF%84%CE%BF%CF%85%CF%81%CE%B9%CE%BA%CE%AC" title="Βαρβιτουρικά – Grieks" lang="el" hreflang="el" data-title="Βαρβιτουρικά" data-language-autonym="Ελληνικά" data-language-local-name="Grieks" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Barbiturate" title="Barbiturate – Engels" lang="en" hreflang="en" data-title="Barbiturate" data-language-autonym="English" data-language-local-name="Engels" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Barbiturato" title="Barbiturato – Esperanto" lang="eo" hreflang="eo" data-title="Barbiturato" data-language-autonym="Esperanto" data-language-local-name="Esperanto" class="interlanguage-link-target"><span>Esperanto</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Barbit%C3%BArico" title="Barbitúrico – Spaans" lang="es" hreflang="es" data-title="Barbitúrico" data-language-autonym="Español" data-language-local-name="Spaans" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Barbituraadid" title="Barbituraadid – Estisch" lang="et" hreflang="et" data-title="Barbituraadid" data-language-autonym="Eesti" data-language-local-name="Estisch" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Barbituriko" title="Barbituriko – Baskisch" lang="eu" hreflang="eu" data-title="Barbituriko" data-language-autonym="Euskara" data-language-local-name="Baskisch" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A8%D8%A7%D8%B1%D8%A8%DB%8C%D8%AA%D9%88%D8%B1%D8%A7%D8%AA" title="باربیتورات – Perzisch" lang="fa" hreflang="fa" data-title="باربیتورات" data-language-autonym="فارسی" data-language-local-name="Perzisch" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Barbituraatit" title="Barbituraatit – Fins" lang="fi" hreflang="fi" data-title="Barbituraatit" data-language-autonym="Suomi" data-language-local-name="Fins" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Barbiturique" title="Barbiturique – Frans" lang="fr" hreflang="fr" data-title="Barbiturique" data-language-autonym="Français" data-language-local-name="Frans" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ga mw-list-item"><a href="https://ga.wikipedia.org/wiki/Barbat%C3%BAr%C3%A1it" title="Barbatúráit – Iers" lang="ga" hreflang="ga" data-title="Barbatúráit" data-language-autonym="Gaeilge" data-language-local-name="Iers" class="interlanguage-link-target"><span>Gaeilge</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Barbit%C3%BArico" title="Barbitúrico – Galicisch" lang="gl" hreflang="gl" data-title="Barbitúrico" data-language-autonym="Galego" data-language-local-name="Galicisch" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%91%D7%A8%D7%91%D7%99%D7%98%D7%95%D7%A8%D7%98" title="ברביטורט – Hebreeuws" lang="he" hreflang="he" data-title="ברביטורט" data-language-autonym="עברית" data-language-local-name="Hebreeuws" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hi mw-list-item"><a href="https://hi.wikipedia.org/wiki/%E0%A4%AC%E0%A4%BE%E0%A4%B0%E0%A5%8D%E0%A4%AC%E0%A5%80%E0%A4%9A%E0%A5%81%E0%A4%B0%E0%A5%87%E0%A4%9F%E0%A5%8D%E0%A4%B8" title="बार्बीचुरेट्स – Hindi" lang="hi" hreflang="hi" data-title="बार्बीचुरेट्स" data-language-autonym="हिन्दी" data-language-local-name="Hindi" class="interlanguage-link-target"><span>हिन्दी</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Barbiturati" title="Barbiturati – Kroatisch" lang="hr" hreflang="hr" data-title="Barbiturati" data-language-autonym="Hrvatski" data-language-local-name="Kroatisch" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D4%B2%D5%A1%D6%80%D5%A2%D5%AB%D5%BF%D5%B8%D6%82%D6%80%D5%A1%D5%BF%D5%B6%D5%A5%D6%80" title="Բարբիտուրատներ – Armeens" lang="hy" hreflang="hy" data-title="Բարբիտուրատներ" data-language-autonym="Հայերեն" data-language-local-name="Armeens" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Barbiturat" title="Barbiturat – Indonesisch" lang="id" hreflang="id" data-title="Barbiturat" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesisch" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Barbiturici" title="Barbiturici – Italiaans" lang="it" hreflang="it" data-title="Barbiturici" data-language-autonym="Italiano" data-language-local-name="Italiaans" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%90%E3%83%AB%E3%83%93%E3%83%84%E3%83%BC%E3%83%AB%E9%85%B8%E7%B3%BB" title="バルビツール酸系 – Japans" lang="ja" hreflang="ja" data-title="バルビツール酸系" data-language-autonym="日本語" data-language-local-name="Japans" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ka mw-list-item"><a href="https://ka.wikipedia.org/wiki/%E1%83%91%E1%83%90%E1%83%A0%E1%83%91%E1%83%98%E1%83%A2%E1%83%A3%E1%83%A0%E1%83%90%E1%83%A2%E1%83%94%E1%83%91%E1%83%98" title="ბარბიტურატები – Georgisch" lang="ka" hreflang="ka" data-title="ბარბიტურატები" data-language-autonym="ქართული" data-language-local-name="Georgisch" class="interlanguage-link-target"><span>ქართული</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%B0%94%EB%A5%B4%EB%B9%84%ED%88%AC%EB%A5%B4%EC%82%B0%EA%B3%84" title="바르비투르산계 – Koreaans" lang="ko" hreflang="ko" data-title="바르비투르산계" data-language-autonym="한국어" data-language-local-name="Koreaans" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Barbit%C5%ABratai" title="Barbitūratai – Litouws" lang="lt" hreflang="lt" data-title="Barbitūratai" data-language-autonym="Lietuvių" data-language-local-name="Litouws" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-lv mw-list-item"><a href="https://lv.wikipedia.org/wiki/Barbitur%C4%81ti" title="Barbiturāti – Lets" lang="lv" hreflang="lv" data-title="Barbiturāti" data-language-autonym="Latviešu" data-language-local-name="Lets" class="interlanguage-link-target"><span>Latviešu</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%91%D0%B0%D1%80%D0%B1%D0%B8%D1%82%D1%83%D1%80%D0%B0%D1%82" title="Барбитурат – Macedonisch" lang="mk" hreflang="mk" data-title="Барбитурат" data-language-autonym="Македонски" data-language-local-name="Macedonisch" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Barbiturat" title="Barbiturat – Maleis" lang="ms" hreflang="ms" data-title="Barbiturat" data-language-autonym="Bahasa Melayu" data-language-local-name="Maleis" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-nn mw-list-item"><a href="https://nn.wikipedia.org/wiki/Barbiturat" title="Barbiturat – Noors - Nynorsk" lang="nn" hreflang="nn" data-title="Barbiturat" data-language-autonym="Norsk nynorsk" data-language-local-name="Noors - Nynorsk" class="interlanguage-link-target"><span>Norsk nynorsk</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Barbiturat" title="Barbiturat – Noors - Bokmål" lang="nb" hreflang="nb" data-title="Barbiturat" data-language-autonym="Norsk bokmål" data-language-local-name="Noors - Bokmål" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Barbiturany" title="Barbiturany – Pools" lang="pl" hreflang="pl" data-title="Barbiturany" data-language-autonym="Polski" data-language-local-name="Pools" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Barbit%C3%BArico" title="Barbitúrico – Portugees" lang="pt" hreflang="pt" data-title="Barbitúrico" data-language-autonym="Português" data-language-local-name="Portugees" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Barbituric" title="Barbituric – Roemeens" lang="ro" hreflang="ro" data-title="Barbituric" data-language-autonym="Română" data-language-local-name="Roemeens" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%91%D0%B0%D1%80%D0%B1%D0%B8%D1%82%D1%83%D1%80%D0%B0%D1%82%D1%8B" title="Барбитураты – Russisch" lang="ru" hreflang="ru" data-title="Барбитураты" data-language-autonym="Русский" data-language-local-name="Russisch" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sah mw-list-item"><a href="https://sah.wikipedia.org/wiki/%D0%91%D0%B0%D1%80%D0%B1%D0%B8%D1%82%D1%83%D1%80%D0%B0%D1%82%D1%82%D0%B0%D1%80" title="Барбитураттар – Jakoets" lang="sah" hreflang="sah" data-title="Барбитураттар" data-language-autonym="Саха тыла" data-language-local-name="Jakoets" class="interlanguage-link-target"><span>Саха тыла</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Barbiturat" title="Barbiturat – Servo-Kroatisch" lang="sh" hreflang="sh" data-title="Barbiturat" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Servo-Kroatisch" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Barbiturate" title="Barbiturate – Simple English" lang="en-simple" hreflang="en-simple" data-title="Barbiturate" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Barbitur%C3%A1t" title="Barbiturát – Slowaaks" lang="sk" hreflang="sk" data-title="Barbiturát" data-language-autonym="Slovenčina" data-language-local-name="Slowaaks" class="interlanguage-link-target"><span>Slovenčina</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Barbiturat" title="Barbiturat – Sloveens" lang="sl" hreflang="sl" data-title="Barbiturat" data-language-autonym="Slovenščina" data-language-local-name="Sloveens" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%91%D0%B0%D1%80%D0%B1%D0%B8%D1%82%D1%83%D1%80%D0%B0%D1%82" title="Барбитурат – Servisch" lang="sr" hreflang="sr" data-title="Барбитурат" data-language-autonym="Српски / srpski" data-language-local-name="Servisch" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-su mw-list-item"><a href="https://su.wikipedia.org/wiki/Barbiturat" title="Barbiturat – Soendanees" lang="su" hreflang="su" data-title="Barbiturat" data-language-autonym="Sunda" data-language-local-name="Soendanees" class="interlanguage-link-target"><span>Sunda</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Barbiturater" title="Barbiturater – Zweeds" lang="sv" hreflang="sv" data-title="Barbiturater" data-language-autonym="Svenska" data-language-local-name="Zweeds" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-tg mw-list-item"><a href="https://tg.wikipedia.org/wiki/%D0%91%D0%B0%D1%80%D0%B1%D0%B8%D1%82%D1%83%D1%80%D0%B0%D1%82%D2%B3%D0%BE" title="Барбитуратҳо – Tadzjieks" lang="tg" hreflang="tg" data-title="Барбитуратҳо" data-language-autonym="Тоҷикӣ" data-language-local-name="Tadzjieks" class="interlanguage-link-target"><span>Тоҷикӣ</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B8%9A%E0%B8%B2%E0%B8%A3%E0%B9%8C%E0%B8%9A%E0%B8%B4%E0%B8%97%E0%B8%B9%E0%B9%80%E0%B8%A3%E0%B8%95" title="บาร์บิทูเรต – Thai" lang="th" hreflang="th" data-title="บาร์บิทูเรต" data-language-autonym="ไทย" data-language-local-name="Thai" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Barbit%C3%BCrat" title="Barbitürat – Turks" lang="tr" hreflang="tr" data-title="Barbitürat" data-language-autonym="Türkçe" data-language-local-name="Turks" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%91%D0%B0%D1%80%D0%B1%D1%96%D1%82%D1%83%D1%80%D0%B0%D1%82%D0%B8" title="Барбітурати – Oekraïens" lang="uk" hreflang="uk" data-title="Барбітурати" data-language-autonym="Українська" data-language-local-name="Oekraïens" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Barbituratlar" title="Barbituratlar – Oezbeeks" lang="uz" hreflang="uz" data-title="Barbituratlar" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="Oezbeeks" class="interlanguage-link-target"><span>Oʻzbekcha / ўзбекча</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Barbiturat" title="Barbiturat – Vietnamees" lang="vi" hreflang="vi" data-title="Barbiturat" data-language-autonym="Tiếng Việt" data-language-local-name="Vietnamees" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-war mw-list-item"><a href="https://war.wikipedia.org/wiki/Barbituriko" title="Barbituriko – Waray" lang="war" hreflang="war" data-title="Barbituriko" data-language-autonym="Winaray" data-language-local-name="Waray" class="interlanguage-link-target"><span>Winaray</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E5%B7%B4%E6%AF%94%E5%A6%A5%E7%B1%BB%E8%8D%AF%E7%89%A9" title="巴比妥类药物 – Chinees" lang="zh" hreflang="zh" data-title="巴比妥类药物" data-language-autonym="中文" data-language-local-name="Chinees" class="interlanguage-link-target"><span>中文</span></a></li><li class="interlanguage-link interwiki-zh-min-nan mw-list-item"><a href="https://zh-min-nan.wikipedia.org/wiki/Barbiturate_io%CC%8Dh-bu%CC%8Dt" title="Barbiturate io̍h-bu̍t – Minnanyu" lang="nan" hreflang="nan" data-title="Barbiturate io̍h-bu̍t" data-language-autonym="閩南語 / Bân-lâm-gú" data-language-local-name="Minnanyu" class="interlanguage-link-target"><span>閩南語 / Bân-lâm-gú</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit 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lang="nl" dir="ltr"><div id="spoiler" align="center" style="margin:1em auto; width:fit-content; overflow:hidden;"><div style="display:flex; align-items:center; justify-content:center; gap:0.5em; border-top:2px solid var(--border-color-subtle,#c8ccd1); border-bottom:2px solid var(--border-color-subtle,#c8ccd1); padding:0.1em 0.2em;"> <div style="min-width:max-content;"><span class="noviewer" typeof="mw:File"><a href="/wiki/Bestand:Esculaap4.svg" class="mw-file-description" title="Esculaap"><img alt="Esculaap" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/66/Esculaap4.svg/26px-Esculaap4.svg.png" decoding="async" width="26" height="40" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/66/Esculaap4.svg/40px-Esculaap4.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/66/Esculaap4.svg/53px-Esculaap4.svg.png 2x" data-file-width="200" data-file-height="300" /></a></span></div> <div style="text-wrap:balance;"><small>Neem het <a href="/wiki/Wikipedia:Voorbehoud_bij_medische_informatie" title="Wikipedia:Voorbehoud bij medische informatie"><i><b>voorbehoud bij medische informatie</b></i></a> in acht.<br />Raadpleeg bij gezondheidsklachten een <a href="/wiki/Arts" title="Arts">arts</a>.</small></div> </div></div> <p><b>Barbituraten</b> zijn <a href="/wiki/Derivaat_(scheikunde)" title="Derivaat (scheikunde)">derivaten</a> van <a href="/wiki/Barbituurzuur" title="Barbituurzuur">barbituurzuur</a> en hebben als <a href="/wiki/GABA-agonist" title="GABA-agonist">GABA-agonist</a> een sterk dempende werking op het <a href="/wiki/Centraal_zenuwstelsel" title="Centraal zenuwstelsel">centraal zenuwstelsel</a>, variërend met de dosis van lichte <a href="/wiki/Sedatie" title="Sedatie">sedatie</a> (kalmerend effect) tot een diepe (onomkeerbare) <a href="/wiki/Coma_(geneeskunde)" title="Coma (geneeskunde)">coma</a> en de dood. </p> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/Bestand:Barbiturate_allgemein.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Barbiturate_allgemein.svg/260px-Barbiturate_allgemein.svg.png" decoding="async" width="260" height="289" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Barbiturate_allgemein.svg/390px-Barbiturate_allgemein.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Barbiturate_allgemein.svg/520px-Barbiturate_allgemein.svg.png 2x" data-file-width="154" data-file-height="171" /></a><figcaption>Algemene structuur van barbituraten</figcaption></figure> <p>Toepassingen zijn onder andere als: </p> <ol><li><a href="/wiki/Slaapmiddel" title="Slaapmiddel">Slaapmiddelen</a></li> <li><a href="/wiki/Kalmeringsmiddelen" title="Kalmeringsmiddelen">Kalmeringsmiddelen</a> (<i>tranquillizers</i>)</li> <li><a href="/wiki/Anti-epileptica" title="Anti-epileptica">Anti-epileptica</a>, met name <a href="/wiki/Fenobarbital" title="Fenobarbital">fenobarbital</a></li> <li><a href="/w/index.php?title=Inductiemiddel_bij_narcose&amp;action=edit&amp;redlink=1" class="new" title="Inductiemiddel bij narcose (de pagina bestaat niet)">Inductiemiddel bij narcose</a>, met name de <a href="/wiki/Natrium" title="Natrium">natriumzouten</a> van <a href="/wiki/Natriumthiopental" title="Natriumthiopental">thiopental</a> en methohexital</li> <li><a href="/wiki/Euthanasie" title="Euthanasie">Euthanaticum</a> (bijvoorbeeld <a href="/wiki/Natriumthiopental" title="Natriumthiopental">natriumthiopental</a>)</li></ol> <p>In 1863 werd barbituurzuur gesynthetiseerd door de Duitse chemicus <a href="/wiki/Adolf_von_Baeyer" title="Adolf von Baeyer">Adolf von Baeyer</a> uit <a href="/wiki/Malonzuur" title="Malonzuur">malonzuur</a> en <a href="/wiki/Ureum" title="Ureum">ureum</a>. In 1903 verscheen het eerste barbituraat <a href="/wiki/Barbital" title="Barbital">barbital</a> onder de merknaam <a href="/wiki/Barbital" title="Barbital">Veronal</a> als <a href="/wiki/Slaapmiddel" title="Slaapmiddel">slaapmiddel</a> op de markt. </p><p>Vóór de ontdekking van echte slaapmiddelen werden daar vooral <a href="/wiki/Kruidachtig" title="Kruidachtig">kruiden</a>, <a href="/wiki/Ethanol" title="Ethanol">alcohol</a> en <a href="/wiki/Opium" title="Opium">opium</a> voor gebruikt. Daarnaast werden <a href="/wiki/Chloraalhydraat" title="Chloraalhydraat">chloraalhydraat</a> en <a href="/wiki/Paraldehyde" title="Paraldehyde">paraldehyde</a> als <a href="/wiki/Chemische_synthese" title="Chemische synthese">synthetisch</a> slaapmiddel gebruikt. Barbituraten vonden daarom makkelijk aftrek om als slaapmiddel te worden toegepast. </p><p>In 1912 werd <a href="/wiki/Fenobarbital" title="Fenobarbital">fenobarbital</a> op de markt gebracht onder de merknaam Luminal. Fenobarbital werkte veel minder versuffend en was, evenals barbital, langwerkend. Het werd daardoor voornamelijk als kalmeringsmiddel toegepast. </p><p>Er werden circa 2500 barbituraten ontwikkeld, waarvan ongeveer 50 ooit voor medisch gebruik zijn geregistreerd. Enkele barbituraten zijn (eerst voorgekomen merknaam in Nederland tussen haakjes): <a href="/w/index.php?title=Amobarbital&amp;action=edit&amp;redlink=1" class="new" title="Amobarbital (de pagina bestaat niet)">amobarbital</a>, <a href="/wiki/Brallobarbital" title="Brallobarbital">brallobarbital</a> (<a href="/wiki/Vesparax" title="Vesparax">Vesparax</a> in combinatie met <a href="/wiki/Hydroxyzine" title="Hydroxyzine">hydroxyzine</a> en secobarbital), <a href="/w/index.php?title=Butalbital&amp;action=edit&amp;redlink=1" class="new" title="Butalbital (de pagina bestaat niet)">butalbital</a>, <a href="/wiki/Butobarbital" title="Butobarbital">butobarbital</a> (Soneryl), <a href="/w/index.php?title=Cyclobarbital&amp;action=edit&amp;redlink=1" class="new" title="Cyclobarbital (de pagina bestaat niet)">cyclobarbital</a>, <a href="/wiki/Fenobarbital" title="Fenobarbital">fenobarbital</a> (Luminal), <a href="/w/index.php?title=Methylfenobarbital&amp;action=edit&amp;redlink=1" class="new" title="Methylfenobarbital (de pagina bestaat niet)">methylfenobarbital</a> (Prominal), <a href="/wiki/Pentobarbital" title="Pentobarbital">pentobarbital</a>, <a href="/w/index.php?title=Secobarbital&amp;action=edit&amp;redlink=1" class="new" title="Secobarbital (de pagina bestaat niet)">secobarbital</a> (<a href="/w/index.php?title=Seconal&amp;action=edit&amp;redlink=1" class="new" title="Seconal (de pagina bestaat niet)">Seconal</a>, of <a href="/wiki/Vesparax" title="Vesparax">Vesparax</a> in combinatie met <a href="/wiki/Hydroxyzine" title="Hydroxyzine">hydroxyzine</a> en secobarbital) en <a href="/wiki/Natriumthiopental" title="Natriumthiopental">thiopental</a>, ook wel <a href="/wiki/Natriumthiopental" title="Natriumthiopental">pentothal</a> genoemd (Nesdonal). </p><p>Allemaal verschillen ze in eigenschappen zoals dosering, voornaamste werkingen, werkingsduur enzovoort. Barbituraten waren een berucht <a href="/wiki/Zelfmoord" title="Zelfmoord">zelfmoordmiddel</a>, bij overdosering treedt er coma met demping van de ademhaling op. Ook werden ze misbruikt waardoor een <a href="/wiki/Vergiftiging" title="Vergiftiging">vergiftiging</a> zoals bij dronkenschap ontstaat. Barbituraten zijn fysiek en psychologisch zeer <a href="/wiki/Verslaving" title="Verslaving">verslavend</a>; in het ergste geval kan staking van inname na langdurig gebruik zelfs dodelijk zijn door het optreden van ernstige <a href="/wiki/Insult" title="Insult">convulsies</a> ('epileptische aanvallen'). Bij kinderen die langdurig <a href="/wiki/Fenobarbital" title="Fenobarbital">fenobarbital</a> tegen <a href="/wiki/Epilepsie" title="Epilepsie">epilepsie</a> gebruikten is een gemiddeld lager <a href="/wiki/Intelligentiemeting" title="Intelligentiemeting">IQ</a> waargenomen, evenals gedragsstoornissen.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup> </p><p>Er bestaat geen antidotum tegen een overdosis barbituraat. Vooral secobarbital veroorzaakte veel doden door vergiftiging wereldwijd, meestal vanwege ernstige problemen met misbruik. </p><p>De <a href="/wiki/Benzodiazepine" title="Benzodiazepine">benzodiazepinen</a> <a href="/wiki/Chloordiazepoxide" title="Chloordiazepoxide">chloordiazepoxide</a> (Librium) en <a href="/wiki/Diazepam" title="Diazepam">diazepam</a> (Valium) werden rond 1960 ontwikkeld. Deze zijn veel veiliger dan de barbituraten. Overdosering is praktisch onmogelijk, afhankelijkheid en ontwenning is minder intens, ze werken over het algemeen minder versuffend, en er zijn eigenlijk maar een paar echte contra-indicaties; zoals de zeldzame spierziekte <a href="/wiki/Myasthenia_gravis" title="Myasthenia gravis">Myasthenia gravis</a>. Toch kunnen mensen lange tijd last krijgen van ontwenningsverschijnselen, veel langer dan bij ontwenning van opioïden of alcoholische dranken.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup> </p><p>Benzodiazepines hebben de functie van barbituraten bijna volledig overgenomen. In de <a href="/wiki/Apotheek" title="Apotheek">apotheek</a> is sinds een paar jaar na de eeuwwisseling alleen nog fenobarbital verkrijgbaar, en dan als <a href="/wiki/Anti-epileptica" title="Anti-epileptica">anti-epilepticum</a>, indien andere middelen falen. In ziekenhuizen wordt ook nog wel het sterke en kortwerkende barbituraat <a href="/wiki/Natriumthiopental" title="Natriumthiopental">thiopental</a> gebruikt als inleidingmiddel bij <a href="/wiki/Anesthesie" title="Anesthesie">anesthesie</a> (of <a href="/wiki/Algehele_anesthesie" title="Algehele anesthesie">narcose</a>). Ook in de diergeneeskunde en bij <a href="/wiki/Euthanasie" title="Euthanasie">euthanasie</a> door middel van <a href="/wiki/Dodelijke_injectie" title="Dodelijke injectie">injectie</a> worden vaak sterke barbituraten gebruikt. </p><p>Van verschillende barbituraten, bijvoorbeeld fenobarbital, secobarbital en amobarbital, is er een <a href="/wiki/Natrium" title="Natrium">natrium</a>-zoutvorm beschikbaar. De naam wordt dan aangeduid als bv. natriumpentobarbital. Het zou gezegd kunnen worden dat natrium een oplosmiddel is, zoals dat bij andere middelen vaak <a href="/wiki/Hydrochloride" title="Hydrochloride">hydrochloride</a> is. Het eerste barbituraat, barbital, kon niet in water opgelost worden. Natriumbarbital, het natriumzout hiervan, kon dat wel, waardoor toediening via injectie en drank makkelijker werden. </p> <div class="toccolours appendix" role="presentation" style="font-size:90%; margin:1em 0 -0.5em; clear:both;"> <div><span style="font-weight:bold">Bronnen, noten en/of referenties</span></div> <div class="reflist" style="list-style-type: decimal;"><div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text"><span class="citation" id="CITEREFFarwell_JR,_Lee_YJ,_Hirtz_DG,_Sulzbacher_SI,_Ellenberg_JH,_Nelson_KB1990"><span style="font-variant:small-caps;">Farwell JR, Lee YJ, Hirtz DG, Sulzbacher SI, Ellenberg JH, Nelson KB</span>&#32;(1990).&#32;<cite>Phenobarbital for febrile seizures—effects on intelligence and on seizure recurrence</cite>. <i>N Engl J Med.</i>&#32;<b>322</b>&#32;(6): 364-9. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/2242106">2242106</a>. </span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text"><span class="citation" id="CITEREFSulzbacher_S,_Farwell_JR,_Temkin_N,_Lu_AS,_Hirtz_DG1999"><span style="font-variant:small-caps;">Sulzbacher S, Farwell JR, Temkin N, Lu AS, Hirtz DG</span>&#32;(1999).&#32;<cite><a rel="nofollow" class="external text" href="https://archive.org/details/sim_clinical-pediatrics_1999-07_38_7/page/387">Late cognitive effects of early treatment with phenobarbital</a></cite>. <i>Clin Pediatr (Phila).</i>&#32;<b>38</b>&#32;(7): 387-94. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/10416094">10416094</a>. </span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text"><span class="citation"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20150115163153/http://www.kinderformularium.nl/search/stof.php?id=288">Fenobarbital</a>.&#32;Kinderformularium.&#32;Gearchiveerd op <span class="mw-formatted-date" title="2015-01-15">15 januari 2015</span>.&#32;Geraadpleegd op <span class="mw-formatted-date" title="2015-01-15">15 januari 2015</span>. </span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="https://benzo.org.uk/manual/">Benzo.org.uk <i>Ashton Manual</i></a> (<a href="/wiki/Heather_Ashton" title="Heather Ashton">Heather Ashton</a>).</span> </li> </ol></div></div> </div> <!-- NewPP limit report Parsed by mw‐web.eqiad.main‐64476968cd‐6hn8q Cached time: 20241102120253 Cache expiry: 2592000 Reduced expiry: false Complications: [] CPU time usage: 0.048 seconds Real time usage: 0.068 seconds Preprocessor visited node count: 843/1000000 Post‐expand include size: 4938/2097152 bytes Template argument size: 1970/2097152 bytes Highest expansion depth: 11/100 Expensive parser function count: 0/500 Unstrip recursion depth: 0/20 Unstrip post‐expand size: 2924/5000000 bytes Lua time usage: 0.003/10.000 seconds Lua memory usage: 625790/52428800 bytes Number of Wikibase entities loaded: 0/400 --> <!-- Transclusion expansion time report (%,ms,calls,template) 100.00% 40.714 1 -total 87.66% 35.691 1 Sjabloon:Appendix 83.00% 33.792 1 Sjabloon:References 24.57% 10.005 2 Sjabloon:Citeer_journal 17.37% 7.072 1 Sjabloon:Citeer_web 5.07% 2.066 2 Sjabloon:Aut 4.55% 1.853 2 Sjabloon:Sfnref 4.45% 1.813 1 Sjabloon:Disclaimer_medisch_lemma --> <!-- Saved in parser cache with key nlwiki:pcache:idhash:214072-0!dateformat=default and timestamp 20241102120253 and revision id 67948724. 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