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width="1.25rem" xmlns="http://www.w3.org/2000/svg"><polyline points="6 9 6 2 18 2 18 9"></polyline><path d="M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2"></path><rect x="6" y="14" width="12" height="8"></rect></svg></a></button></div></div><div><div class="flex flex-wrap"><p class=" text-primary font-semibold">News</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1"></div><p class=" text-primary font-semibold">Article</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1 "></div><time class="text-gray-500 " dateTime="2024-10-23T16:00:00.000">October 23, 2024</time></div><h1 class="text-[26px] font-medium leading-8">GSK's Arexvy Vaccine Shows Strong Efficacy Against RSV in Older Adults</h1><div class="py-3 text-gray-600 md:flex flex-col md:justify-between"><div class="flex flex-col xs:flex-row"><p class="mr-1 self-start">Author(s):</p><div class="flex flex-col xs:flex-row mb-3 md:mb-0"><div class="flex flex-wrap"><span class="text-md 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lg:justify-end"></div><div class="w-full flex flex-col px-4 py-4 border-t border-b border-solid border-gray-400 my-4 "><h3 class="text-primary text-xl font-semibold">Key Takeaways</h3><ul class="list-disc px-8"><li class="py-2 "> Arexvy shows 62.9% efficacy against RSV-LRTD over three seasons in adults aged 60 and older. </li><li class="py-2 "> The vaccine demonstrates 67.4% efficacy against severe RSV-LRTD, with consistent safety data. </li><li class="py-2 hidden"> Arexvy is the first RSV vaccine with efficacy and safety data over three full seasons. </li><li class="py-2 hidden"> GSK aims to provide long-term data to guide revaccination schedules for older adults.</li></ul><span class="text-xs font-bold text-primary underline cursor-pointer mt-2 ml-4">SHOW MORE</span></div><p class="py-2 mb-2 text-sm italic text-gray-600">The vaccine proved a cumulative efficacy of 62.9% against respiratory syncytial virus (RSV)-related lower respiratory tract disease in older adults over 3 seasons.</p><div class="py-2"><div class="blockText_blockContent__TbCXh"><p class="pb-2">This article was originally published on <a target="_blank" href="https://www.contagionlive.com/"><em>ContagionLive</em></a>®. </p><p class="pb-2"></p><p class="pb-2">GSK has announced promising results for Arexvy, its<a target="_blank" href="https://www.ajmc.com/compendium/rsv"> respiratory syncytial virus</a> (RSV) vaccine, showing a cumulative efficacy of 62.9% against RSV-related lower respiratory tract disease (RSV-LRTD) over 3 full RSV seasons in adults aged 60 years and older. This vaccine is the only one with efficacy and safety data available through 3 full seasons, including in individuals at increased risk due to underlying medical conditions.<sup class="text-inherit">1</sup></p><p class="pb-2"><sup class="text-inherit"></sup></p><div class=""><div style="width:33%;float:left;max-width:525px;margin:0 1.5rem 1.5rem 0;clear:both;cursor:" class=" figure"><div class="flex-none relative text-center"><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;max-width:100%"><img style="display:block;max-width:100%;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0" alt="" aria-hidden="true" src="data:image/svg+xml,%3csvg%20xmlns=%27http://www.w3.org/2000/svg%27%20version=%271.1%27%20width=%275568%27%20height=%273712%27/%3e"/></span><img alt="RSV vaccine vial with syringe - Respiratory syncytial virus shot | MargJohnsonVA - stock.adobe.com" title="RSV vaccine vial with syringe - Respiratory syncytial virus shot | MargJohnsonVA - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="RSV vaccine vial with syringe - Respiratory syncytial virus shot | MargJohnsonVA - stock.adobe.com" title="RSV vaccine vial with syringe - Respiratory syncytial virus shot | MargJohnsonVA - stock.adobe.com" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F8287ab160a0fbc0fb0436cd45688b013079d9da4-5568x3712.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 1x" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F8287ab160a0fbc0fb0436cd45688b013079d9da4-5568x3712.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div id="image-caption" class="text-gray-500 italic"><div class="blockText_blockContent__TbCXh"><p class="pb-2"><div style="text-align:center">The vaccine proved a cumulative efficacy of 62.9% against respiratory syncytial virus-related lower respiratory tract disease in older adults over 3 seasons. | Image credit: MargJohnsonVA - stock.adobe.com</div></p></div></div><div class="top-[-100%] block w-[1px] transition-opacity duration-500 ease-in-out opacity-0 overflow-hidden"><img class="m-auto absolute inset-0 max-w-[0%] max-h-[0%] border-[3px] border-solid border-white shadow-[0px_0px_8px_rgba(0,0,0,0.3)] box-border transition ease-in-out duration-500" src="https://cdn.sanity.io/images/0vv8moc6/ajmc/8287ab160a0fbc0fb0436cd45688b013079d9da4-5568x3712.jpg?fit=crop&auto=format"/></div></div><style> #image-caption p{ font-size: 12px; max-width: 525px; margin: 0 auto; text-align: center; } </style></div><p class="pb-2">The findings were presented at the <a target="_blank" href="https://www.ajmc.com/conference/chest">CHEST 2024 Annual Meeting</a>, indicating 67.4% efficacy against severe RSV-LRTD. In the third season, the vaccine's efficacy was 48% against RSV-LRTD (95% CI, 8.7-72). The safety profile is consistent with previous phase 3 results, where the most frequently reported side effects included injection site pain, fatigue, myalgia, headache, and arthralgia within four days of vaccination.</p><p class="pb-2"><sup class="text-inherit"></sup></p><p class="pb-2">GSK plans to continue providing long-term efficacy and immune response data to help inform revaccination schedules. RSV impacts an estimated 64 million people globally each year and can lead to severe outcomes, causing over 465,000 hospitalizations and 33,000 deaths annually among adults aged 60 and older in high-income countries.</p><p class="pb-2"></p><p class="pb-2">“We are excited by these new data which show that a single dose of Arexvy<em> </em>could help protect millions of older adults at risk of RSV disease over three seasons to benefit public health," Tony Wood, chief scientific officer at GSK, said in a statement. "This is the only RSV vaccine with efficacy and safety data available through 3 full seasons. We will continue to provide data on longer term follow-up to help recommending bodies determine future revaccination schedules.”</p><p class="pb-2"></p><p class="pb-2">Arexvy was approved by the FDA in May 2023 for preventing RSV-LRTD in individuals aged 60 and older. Since then, it has received approvals in 50 countries, including Europe and Japan. <a target="_blank" href="https://www.contagionlive.com/view/fda-approves-gsk-s-arexvy-as-the-world-s-first-rsv-vaccine-for-older-adults">This approval</a> was based on the US phase 3 trial data that showed 82.6% efficacy against RSV related lower respiratory tract disease and 94.6% efficacy in patients with comorbidities. Arexvy combines the preF fusion protein with the AS01 adjuvant to enhance immune response in aging populations.<sup class="text-inherit">2</sup></p><p class="pb-2"><sup class="text-inherit"></sup></p><p class="pb-2">The ongoing research aims to provide further insights into the vaccine's long-term effectiveness and the necessity for potential revaccination.</p><p class="pb-2"></p><p class="pb-2"><strong>References</strong></p><ol class="my-2"><li class="list-decimal ml-8">GSK presents positive data for Arexvy, its respiratory syncytial virus (RSV) vaccine, indicating protection over three RSV seasons. GSK. October 8, 2024. Accessed October 21, 2024. <a rel="nofollow noreferrer noopener" target="_blank" href="https://www.gsk.com/en-gb/media/press-releases/gsk-presents-positive-data-for-arexvy-its-rsv-vaccine-indicating-protection-over-three-rsv-seasons/">https://www.gsk.com/en-gb/media/press-releases/gsk-presents-positive-data-for-arexvy-its-rsv-vaccine-indicating-protection-over-three-rsv-seasons/</a></li><li class="list-decimal ml-8">Cosdon, N. FDA approves GSK’s Arexvy as the world’s first RSV vaccine for older adults. <em>Contagion.</em> May 3, 2024. Accessed October 21, 2024. <a target="_self" href="https://www.contagionlive.com/view/fda-approves-gsk-s-arexvy-as-the-world-s-first-rsv-vaccine-for-older-adults">https://www.contagionlive.com/view/fda-approves-gsk-s-arexvy-as-the-world-s-first-rsv-vaccine-for-older-adults</a></li></ol></div></div><div class="flex items-center lg:w-3/4 mb-4 pb-12"></div><div class="jsx-19ede9f0a5a45918 py-4 relative bg-primary md:px-8 -ml-6 xs:ml-0 w-screen xs:w-auto"><div class="jsx-19ede9f0a5a45918 px-4 sm:px-0"><div class="flex justify-between items-center py-1 space-x-4 border-0 select-none sm:border-b border-secondary"><div class="text-3xl text-white text-lg sm:text-3xl">Related Videos</div></div></div><div style="scroll-snap-type:none" class="jsx-19ede9f0a5a45918 flex items-start overflow-x-auto space-x-4 py-4 relative mx-auto w-full pl-4"><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" 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Bernstein, MD, highlights the need for prolonged antibiotics and strong public health measures to combat tuberculosis (TB) at both the individual and population levels.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/bird-flu-risks-myths-and-prevention-strategies-a-conversation-with-the-nfid-s-dr-robert-hopkins?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="Bird Flu Risks, Myths, and Prevention Strategies: A Conversation With the NFID's Dr Robert Hopkins" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 21st 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/bird-flu-risks-myths-and-prevention-strategies-a-conversation-with-the-nfid-s-dr-robert-hopkins?utm_source=www.ajmc.com&utm_medium=relatedContent">Bird Flu Risks, Myths, and Prevention Strategies: A Conversation With the NFID's Dr Robert Hopkins</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/bird-flu-risks-myths-and-prevention-strategies-a-conversation-with-the-nfid-s-dr-robert-hopkins?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Joining us for this episode of Managed Care Cast is Robert H. Hopkins Jr, MD, medical director at the National Foundation for Infectious Diseases (NFID), who will help separate fact from fiction about avian influenza and discuss what needs to be done to prevent a future escalation.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/kansas-city-tuberculosis-outbreak-highlights-ongoing-public-health-challenge?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/abf32b176779ed8b8deb698f70dea44d4cd5d501-5733x3780.jpg?fit=crop&auto=format" alt="Tuberculosis illustration | Image Credit: tashatuvango - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 11th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/kansas-city-tuberculosis-outbreak-highlights-ongoing-public-health-challenge?utm_source=www.ajmc.com&utm_medium=relatedContent">Kansas City Tuberculosis Outbreak Highlights Ongoing Public Health Challenge</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/kansas-city-tuberculosis-outbreak-highlights-ongoing-public-health-challenge?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In an interview with The American Journal of Managed Care, Michael A. Bernstein, MD, stressed the need for effective communication and proactive screening to curb the recent tuberculosis (TB) outbreak.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/promising-cancer-vaccine-boosts-hope-for-stage-iii-and-iv-kidney-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a65624d0e5f9648d28cc062148797de34d0f2a3e-5696x3328.jpg?fit=crop&auto=format" alt="AI concept of cancer vaccine | Image credit: radekcho - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 5th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/promising-cancer-vaccine-boosts-hope-for-stage-iii-and-iv-kidney-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent">Promising Cancer Vaccine Boosts Hope for Stage III and IV Kidney Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/promising-cancer-vaccine-boosts-hope-for-stage-iii-and-iv-kidney-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">All patients involved in the phase 1 trial of a personalized cancer vaccine for high-risk stage III/IV kidney cancer showed a successful anticancer immune response.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="relative hidden sm:block"><div class="mt-4 overflow-hidden"><div class="flex justify-between"><div class="flex items-center clear-both pt-4 pb-2 text-3xl lg:text-2xl xl:text-3xl min-w-fit ">Related Content </div><div class="hidden lg:flex w-full flex-col justify-end items-end"><div class="hidden w-full lg:flex flex-wrap pb-2 gap-x-2 gap-y-1 justify-end items-end"></div></div></div><div class="w-full mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/oral-roflumilast-shows-promise-for-moderate-to-severe-psoriasis?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/d4dbfbb28c64d40bf551603cecf09c8fabcb009b-8268x4632.jpg?fit=crop&auto=format" alt="Psoriasis oral treatment | Image credit: Pawel - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 13th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/oral-roflumilast-shows-promise-for-moderate-to-severe-psoriasis?utm_source=www.ajmc.com&utm_medium=relatedContent">Oral Roflumilast Shows Promise for Moderate to Severe Psoriasis</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/oral-roflumilast-shows-promise-for-moderate-to-severe-psoriasis?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Roflumilast demonstrated effectiveness and safety in treating psoriasis, with added benefits for patients with comorbidities.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/politics-vs-science-the-future-of-us-public-health?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="Managed Care Cast Logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 4th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/politics-vs-science-the-future-of-us-public-health?utm_source=www.ajmc.com&utm_medium=relatedContent">Politics vs Science: The Future of US Public Health</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/perry-n-halkitis-phd-ms-mph">Perry N. Halkitis, PhD, MS, MPH</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/politics-vs-science-the-future-of-us-public-health?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we speak with Perry N. Halkitis, PhD, MS, MPH, dean of the Rutgers School of Public Health, on the public health implications of the US withdrawal from the World Health Organization and the role of public health leaders in advocating for science and health.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/understanding-tb-symptoms-spread-treatment-amid-kansas-city-outbreak?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4e67a71e53a44a0736c2c37c0e31fa17cf1c24cc-2876x1537.png?fit=crop&auto=format" alt="Dr Michael Bernstein" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 13th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/understanding-tb-symptoms-spread-treatment-amid-kansas-city-outbreak?utm_source=www.ajmc.com&utm_medium=relatedContent">Understanding TB Symptoms, Spread, Treatment Amid Kansas City Outbreak</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/michael-a-bernstein-md">Michael A. Bernstein, MD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/understanding-tb-symptoms-spread-treatment-amid-kansas-city-outbreak?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In part 2 of this interview, Michael A. Bernstein, MD, highlights the need for prolonged antibiotics and strong public health measures to combat tuberculosis (TB) at both the individual and population levels.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/bird-flu-risks-myths-and-prevention-strategies-a-conversation-with-the-nfid-s-dr-robert-hopkins?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="Bird Flu Risks, Myths, and Prevention Strategies: A Conversation With the NFID's Dr Robert Hopkins" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 21st 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/bird-flu-risks-myths-and-prevention-strategies-a-conversation-with-the-nfid-s-dr-robert-hopkins?utm_source=www.ajmc.com&utm_medium=relatedContent">Bird Flu Risks, Myths, and Prevention Strategies: A Conversation With the NFID's Dr Robert Hopkins</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/bird-flu-risks-myths-and-prevention-strategies-a-conversation-with-the-nfid-s-dr-robert-hopkins?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Joining us for this episode of Managed Care Cast is Robert H. Hopkins Jr, MD, medical director at the National Foundation for Infectious Diseases (NFID), who will help separate fact from fiction about avian influenza and discuss what needs to be done to prevent a future escalation.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/kansas-city-tuberculosis-outbreak-highlights-ongoing-public-health-challenge?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/abf32b176779ed8b8deb698f70dea44d4cd5d501-5733x3780.jpg?fit=crop&auto=format" alt="Tuberculosis illustration | Image Credit: tashatuvango - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 11th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/kansas-city-tuberculosis-outbreak-highlights-ongoing-public-health-challenge?utm_source=www.ajmc.com&utm_medium=relatedContent">Kansas City Tuberculosis Outbreak Highlights Ongoing Public Health Challenge</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/kansas-city-tuberculosis-outbreak-highlights-ongoing-public-health-challenge?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In an interview with The American Journal of Managed Care, Michael A. Bernstein, MD, stressed the need for effective communication and proactive screening to curb the recent tuberculosis (TB) outbreak.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/promising-cancer-vaccine-boosts-hope-for-stage-iii-and-iv-kidney-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a65624d0e5f9648d28cc062148797de34d0f2a3e-5696x3328.jpg?fit=crop&auto=format" alt="AI concept of cancer vaccine | Image credit: radekcho - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 5th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/promising-cancer-vaccine-boosts-hope-for-stage-iii-and-iv-kidney-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent">Promising Cancer Vaccine Boosts Hope for Stage III and IV Kidney Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/promising-cancer-vaccine-boosts-hope-for-stage-iii-and-iv-kidney-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">All patients involved in the phase 1 trial of a personalized cancer vaccine for high-risk stage III/IV kidney cancer showed a successful anticancer immune response.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="pb-24"></div></div><script type="application/ld+json">{"@context":"https://schema.org","@type":"NewsArticle","headline":"GSK's Arexvy Vaccine Shows Strong Efficacy Against RSV in Older Adults","datePublished":"2024-10-23T16:00:00.000Z","dateModified":"2024-10-21T16:39:26Z","inLanguage":"en-US","image":"https://cdn.sanity.io/images/0vv8moc6/ajmc/8287ab160a0fbc0fb0436cd45688b013079d9da4-5568x3712.jpg?fit=crop&auto=format","mainEntityOfPage":{"@type":"WebPage","@id":"https://www.ajmc.com/view/gsk-s-arexvy-vaccine-shows-strong-efficacy-against-rsv-in-older-adults"},"publisher":{"@type":"Organization","name":"AJMC","logo":{"@type":"ImageObject","url":"https://www.ajmc.com/ajmc_logo_inverted.png"}},"keywords":"Arexvy,RSV in older adults,GSK,RSV vaccine","articleBody":"This article was originally published on ContagionLive®. \n\n\n\nGSK has announced promising results for Arexvy, its respiratory syncytial virus (RSV) vaccine, showing a cumulative efficacy of 62.9% against RSV-related lower respiratory tract disease (RSV-LRTD) over 3 full RSV seasons in adults aged 60 years and older. This vaccine is the only one with efficacy and safety data available through 3 full seasons, including in individuals at increased risk due to underlying medical conditions.1\n\n\n\n\n\nThe findings were presented at the CHEST 2024 Annual Meeting, indicating 67.4% efficacy against severe RSV-LRTD. In the third season, the vaccine's efficacy was 48% against RSV-LRTD (95% CI, 8.7-72). The safety profile is consistent with previous phase 3 results, where the most frequently reported side effects included injection site pain, fatigue, myalgia, headache, and arthralgia within four days of vaccination.\n\n\n\nGSK plans to continue providing long-term efficacy and immune response data to help inform revaccination schedules. RSV impacts an estimated 64 million people globally each year and can lead to severe outcomes, causing over 465,000 hospitalizations and 33,000 deaths annually among adults aged 60 and older in high-income countries.\n\n\n\n“We are excited by these new data which show that a single dose of Arexvy could help protect millions of older adults at risk of RSV disease over three seasons to benefit public health,\" Tony Wood, chief scientific officer at GSK, said in a statement. \"This is the only RSV vaccine with efficacy and safety data available through 3 full seasons. We will continue to provide data on longer term follow-up to help recommending bodies determine future revaccination schedules.”\n\n\n\nArexvy was approved by the FDA in May 2023 for preventing RSV-LRTD in individuals aged 60 and older. Since then, it has received approvals in 50 countries, including Europe and Japan. This approval was based on the US phase 3 trial data that showed 82.6% efficacy against RSV related lower respiratory tract disease and 94.6% efficacy in patients with comorbidities. Arexvy combines the preF fusion protein with the AS01 adjuvant to enhance immune response in aging populations.2\n\n\n\nThe ongoing research aims to provide further insights into the vaccine's long-term effectiveness and the necessity for potential revaccination.\n\n\n\nReferences\n\nGSK presents positive data for Arexvy, its respiratory syncytial virus (RSV) vaccine, indicating protection over three RSV seasons. GSK. October 8, 2024. Accessed October 21, 2024. https://www.gsk.com/en-gb/media/press-releases/gsk-presents-positive-data-for-arexvy-its-rsv-vaccine-indicating-protection-over-three-rsv-seasons/\n\nCosdon, N. FDA approves GSK’s Arexvy as the world’s first RSV vaccine for older adults. Contagion. May 3, 2024. Accessed October 21, 2024. https://www.contagionlive.com/view/fda-approves-gsk-s-arexvy-as-the-world-s-first-rsv-vaccine-for-older-adults","description":"The vaccine proved a cumulative efficacy of 62.9% against respiratory syncytial virus (RSV)-related lower respiratory tract disease in older adults over 3 seasons.","author":[{"@type":"Person","name":"Sophia Abene "}]}</script></div></div><div class="flex-none w-[300px] z-[9999] relative hidden md:block"><div style="top:5rem" class="sticky custom-spacing"><div class="collapse-container " style="overflow:hidden;max-height:900px;transition:max-height .4s ease-in-out"></div></div></div></div><div id="div-gpt-ad-pixel" style="width:1px;height:1px" class=""></div><noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NK5KQXS" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript><div id="footerOuterWrap" class=" mx-auto flex"><div class="bg-[#00598D] xl:w-[70%] w-[70%] py-12 pl-auto"><div 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This study aims to evaluate oral roflumilast in a real-world prospective cohort of patients with plaque psoriasis, focusing on clinical effectiveness and safety profile.”"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"","_key":"e43f0d44abd3"}],"_type":"block","style":"normal","_key":"c68ff4d5b64e","markDefs":[]},{"markDefs":[{"nofollow":false,"blank":true,"_type":"link","href":"https://www.ajmc.com/compendium/copd","_key":"1a4211ac8697"}],"children":[{"_type":"span","marks":[],"text":"Roflumilast was initially approved by the FDA in 2011 as oral treatment for patients with severe ","_key":"8e2e500fb10a"},{"_type":"span","marks":["1a4211ac8697"],"text":"chronic obstructive pulmonary disease","_key":"926fb81930c6"},{"_type":"span","marks":[],"text":" (COPD) with recurrent exacerbations.","_key":"b16c0927b86e"},{"_type":"span","marks":["sup"],"text":"2 ","_key":"8faf6c7d2c4f"},{"_type":"span","marks":[],"text":"In 2022, topical roflumilast 0.3% cream was FDA-approved for the treatment of plaque psoriasis in patients 12 years and older, marking it as the first topical PDE4 inhibitor for this condition. 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Additionally, a modified nonresponder imputation (mNRI) analysis was used to classify patients as nonresponders if they discontinued treatment due to lack of response, while an NRI intent-to-treat (NRI-ITT) analysis classified all patients who discontinued treatment as nonresponders. ","_key":"69b0bb91665b","_type":"span","marks":[]}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"","_key":"45c781a051b0"}],"_type":"block","style":"normal","_key":"7116ce976ce8","markDefs":[]},{"children":[{"_key":"abea1fd99e80","_type":"span","marks":[],"text":"Safety outcomes, including adverse events and reasons for discontinuation, were monitored throughout the study."}],"_type":"block","style":"normal","_key":"0785ff895fab","markDefs":[]},{"markDefs":[],"children":[{"text":"","_key":"47a5a21af395","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"61827009079d"},{"_key":"fa83b7c19b0f","markDefs":[],"children":[{"_type":"span","marks":[],"text":"A total of 58 patients were included in the study. The baseline mean (SD) PASI score was 13.7 (5.5), and 72.8% of patients were classified as overweight or obese. By week 24, 63% of patients achieved PASI less than 5, 47.8% achieved PASI less than 3, and 21.7% achieved PASI less than 1. 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The study, conducted in Portugal, highlighted roflumilast's potential as a cost-effective and safe treatment option, especially for patients with comorbidities or limited access to biologic therapies. Despite mild gastrointestinal symptoms, no serious adverse events were reported. Limitations included a small cohort size and lack of direct comparisons with other therapies. 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What makes certain communities more vulnerable to outbreaks?","_key":"f5ce6d120710"}],"_type":"block","style":"normal","_key":"0642d423c493"},{"style":"normal","_key":"a6b5a5565a89","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"10992e70381e"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"TB really is a disease that, internationally, upwards of two-thirds of the world will either have been infected and cleared of TB, or have certainly been highly exposed to TB during their life. In countries like the US, we don't face TB as strongly as most of the rest of the world does. The communities that have been at the biggest risk for TB in the US for years are immigrant or recent immigrant communities, and particularly over the last 30 years or 40 years, HIV or HIV-positive patients. There's a number of medications that we use for a whole series of different diseases, usually autoimmune diseases, that can put patients at risk for TB. 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KDHE also ","_key":"ad85618c2703"},{"_type":"span","marks":["297481f79391"],"text":"reported","_key":"c4435a28ce96"},{"_key":"629a39d8cdd3","_type":"span","marks":[],"text":" 67 active TB outbreak-related cases in the Kansas City metro area, with 60 in Wyandotte County and 7 in Johnson County."},{"_type":"span","marks":["sup"],"text":"2","_key":"938a5b15b2cd"},{"marks":[],"text":" Additionally, there have been 79 outbreak-associated latent TB cases, with 77 in Wyandotte County and 2 in Johnson County; those with latent TB infections are not infectious to other people and do not feel sick.","_key":"7b075f665172","_type":"span"}],"_type":"block"},{"_key":"bd3ea2568a58","markDefs":[],"children":[{"marks":[],"text":"","_key":"84d4c3e81996","_type":"span"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Of those with active TB, 35 have completed treatment and are considered cured, while 30 are currently under treatment.","_key":"11dc8f33a586"},{"marks":["sup"],"text":"1","_key":"ebebfb6664a4","_type":"span"},{"_type":"span","marks":[],"text":" Similarly, 31 of those with latent TB have completed treatment, and 28 are currently under treatment. Although the outbreak is ongoing, KDHE emphasized the “very low risk of infection to the general public.” ","_key":"aa5717d76e53"}],"_type":"block","style":"normal","_key":"691069c41f58"},{"markDefs":[],"children":[{"text":"","_key":"6bce4c69aa88","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"b381df6e1eac"},{"_type":"block","style":"normal","_key":"1ca646184319","markDefs":[],"children":[{"_key":"f89681602b3b","_type":"span","marks":[],"text":"To limit the spread of TB, KDHE is actively identifying and testing at-risk individuals and possible close contacts. Those who test positive are further screened to determine if they have active or latent TB infection, which will help identify the best treatment."}]},{"children":[{"_type":"span","marks":[],"text":"","_key":"cd3b73b5d102"}],"_type":"block","style":"normal","_key":"804f4006166b","markDefs":[]},{"markDefs":[{"_key":"991237dd70a3","nofollow":false,"blank":true,"_type":"link","href":"https://www.ajmc.com/view/tuberculosis-through-time-historic-burden-modern-challenges"}],"children":[{"_type":"span","marks":[],"text":"TB typically ","_key":"ce1c08d5ea91"},{"_type":"span","marks":["991237dd70a3"],"text":"affects","_key":"3911b767d4b8"},{"_type":"span","marks":[],"text":" the lungs and is caused by bacteria that spread through the air when infected people sneeze, cough, or spit.","_key":"a25fb21be29e"},{"_key":"c671f6976dcd","_type":"span","marks":["sup"],"text":"3"},{"_type":"span","marks":[],"text":" Common symptoms include cough, fatigue, weight loss, and chest pain. Individuals at an increased risk for TB include those with diabetes, HIV, and weakened immune systems, along with those who are malnourished or use tobacco.","_key":"045d09c6276a"}],"_type":"block","style":"normal","_key":"70b21a667fec"},{"children":[{"_type":"span","marks":[],"text":"","_key":"ab3ded79eb81"}],"_type":"block","style":"normal","_key":"34b70268a47f","markDefs":[]},{"_key":"c85d2b2e9b1b","markDefs":[],"children":[{"marks":[],"text":"Daily antibiotic treatment for 4 to 6 months is recommended for patients with latent and active TB. It is considered dangerous to stop treatment early as it can cause TB to become drug-resistant. After becoming unresponsive to standard drugs, patients with drug-resistant TB require more toxic treatment.","_key":"765912801007","_type":"span"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"55edfc26736a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"a83ec160a779"}]},{"children":[{"_type":"span","marks":[],"text":"In an interview with the ","_key":"ca945a0a80f4"},{"_type":"span","marks":["em"],"text":"American Journal of Managed Care","_key":"ccbaba2294d0"},{"_type":"span","marks":["sup"],"text":"®","_key":"305b97409527"},{"_type":"span","marks":[],"text":", Michael A. Bernstein, MD, director for pulmonary and critical care at Stamford Health, discussed lessons from the COVID-19 pandemic that can be applied to managing the Kansas City TB outbreak. He emphasized the importance of balanced communication to ensure the public remains cautious without causing unnecessary alarm.","_key":"bab3f9008c7e"}],"_type":"block","style":"normal","_key":"fbe1bad242e1","markDefs":[]},{"style":"normal","_key":"e1a51aeb013e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"20ac1ede88f8"}],"_type":"block"},{"markDefs":[],"children":[{"text":"“It’s an ongoing process to make sure you get the right information to the right amount of people in the right way,” Bernstein said.","_key":"ed881ad2d9db","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"1fb2f2860220"},{"_key":"4f7ede1caf96","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"debe28318a86"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"4d2ec1f16266","markDefs":[],"children":[{"marks":[],"text":"He also highlighted the critical role of public health departments in tracking infections and screening at-risk individuals.","_key":"deb7cf050741","_type":"span"}]},{"_key":"875bb230b1aa","markDefs":[],"children":[{"_key":"72a98a6059a7","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"“…they’re an important part of our community, and it’s always easier to play a little bit of offense to identify people at risk than a defensive position when there’s already an outbreak going on,” Bernstein said.","_key":"61ab813d4a5e"}],"_type":"block","style":"normal","_key":"a71dab0dca1e","markDefs":[]},{"_type":"block","style":"normal","_key":"aafd5ba0c06f","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"054837da1144"}]},{"children":[{"_type":"span","marks":["strong"],"text":"Rise in TB Cases Worldwide","_key":"645f2243344b"}],"_type":"block","style":"h4","_key":"95b4ec39ca20","markDefs":[]},{"_type":"block","style":"normal","_key":"d7fee91a0c37","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"a026fbbaa4b7"}]},{"children":[{"_type":"span","marks":[],"text":"This recent rise in TB incidence is not exclusive to the Kansas City metro area; it has been observed nationwide and globally. 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