CINXE.COM
COPD
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class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/brooke-mccormick"><i>Brooke McCormick</i></a></span></div></div><a href="/view/low-birth-weight-linked-to-increased-copd-risk"><a href="/view/low-birth-weight-linked-to-increased-copd-risk"><p class="mt-1 text-gray-800 text-[13px] line-clamp-6 text-hidden">Low birth weight is associated with an increased risk of chronic obstructive pulmonary disease (COPD), particularly among smokers, highlighting the impact of early-life factors on respiratory health.</p></a></a></div></div><div class="flex-wrap w-[60%] flex "><a class="flex w-[50%] flex-col sm:pl-[35px] pl-[20px] pb-[35px] " href="/view/top-5-most-read-copd-content-of-2024"><div class="w-full lg:h-[134px] h-[100px] relative bg-default-logo-background "><span 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class="flex flex-wrap w-full pb-4"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/higher-dietary-magnesium-intake-linked-to-reduced-frailty-risk-in-patients-with-copd"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/580a052b493a3b418abdea66d6cb748f3f4d76af-5696x4016.jpg?fit=crop&auto=format" alt="Foods containing magnesium (Mg) | Image Credit: Yulia Furman - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 9th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/higher-dietary-magnesium-intake-linked-to-reduced-frailty-risk-in-patients-with-copd">Higher Dietary Magnesium Intake Linked to Reduced Frailty Risk in Patients With COPD</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/higher-dietary-magnesium-intake-linked-to-reduced-frailty-risk-in-patients-with-copd"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Higher dietary magnesium intake is associated with a reduced risk of frailty in patients with chronic obstructive pulmonary disease (COPD), emphasizing its potential role in improving clinical outcomes.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/medicare-competitive-bidding-program-cuts-spending-without-impacting-copd-outcomes"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/df116cc327e8da9c4ce9ff4e2190da19a6e4f737-5568x3712.jpg?fit=crop&auto=format" alt="Patient receiving supplemental oxygen therapy | Image Credit: Doodeez - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/medicare-competitive-bidding-program-cuts-spending-without-impacting-copd-outcomes">Medicare Competitive Bidding Program Cuts Spending Without Impacting COPD Outcomes</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/medicare-competitive-bidding-program-cuts-spending-without-impacting-copd-outcomes"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">While the Medicare Competitive Bidding Program reduced spending, it did not significantly impact supplemental oxygen use or clinical outcomes among patients with chronic obstructive pulmonary disease (COPD).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/2025-gold-report-new-insights-on-copd-risks-management"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6418bb32610c66a6b058609e8b3c2d21368ccb96-4200x3900.jpg?fit=crop&auto=format" alt="COPD illustration | Image Credit: peterschreiber.media - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/2025-gold-report-new-insights-on-copd-risks-management">2025 GOLD Report: New Insights on COPD Risks, Management</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/tim-smith">Tim Smith</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/2025-gold-report-new-insights-on-copd-risks-management"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The 2025 Global Initiative for Chronic Obstructive Lung Disease (GOLD) report highlighted climate change, cardiovascular risk, and pulmonary hypertension.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/social-isolation-linked-to-increased-mortality-in-patients-with-copd"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3e5c760c89948ea062bc8055186b9134ab330099-3498x2332.jpg?fit=crop&auto=format" alt="Lonely patient | Image Credit: amazing studio - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/social-isolation-linked-to-increased-mortality-in-patients-with-copd">Social Isolation Linked to Increased Mortality in Patients With COPD</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/social-isolation-linked-to-increased-mortality-in-patients-with-copd"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Social isolation significantly increases the risk of mortality in patients with chronic obstructive pulmonary disease (COPD), highlighting the need for targeted interventions to address this issue.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/higher-life-s-essential-8-scores-associated-with-reduced-copd-risk"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/99ba1fc8facb0591f42220892f8bc106716e5355-3486x2298.jpg?fit=crop&auto=format" alt="Closeup of hand with cardiogram on red heart | Image Credit: Syda Productions - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 21st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/higher-life-s-essential-8-scores-associated-with-reduced-copd-risk">Higher Life’s Essential 8 Scores Associated With Reduced COPD Risk</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/higher-life-s-essential-8-scores-associated-with-reduced-copd-risk"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Higher Life’s Essential 8 (LE8) scores, especially those reflecting lower nicotine exposure and better sleep health, are inversely associated with chronic obstructive pulmonary disease (COPD) risk, emphasizing the importance of cardiovascular health (CVH) in disease prevention.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/copd-mortality-falls-in-china-yet-high-burden-persists-in-underdeveloped-regions"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/cc10b4fed87770b004e25c8c18aa997901f73674-5760x3840.jpg?fit=crop&auto=format" alt="China animation | Image Credit: vegefox.com - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 12th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/copd-mortality-falls-in-china-yet-high-burden-persists-in-underdeveloped-regions">COPD Mortality Falls in China, Yet High Burden Persists in Underdeveloped Regions</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/copd-mortality-falls-in-china-yet-high-burden-persists-in-underdeveloped-regions"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Chronic obstructive pulmonary disease (COPD) burden remains high in underdeveloped regions of China despite a decline in related deaths, highlighting the need for targeted management and prevention strategies.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-7"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/prednisone-superior-to-other-corticosteroids-for-patients-with-copd-heart-failure"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9b3f4e15105a025d5a6db303c6181c2512657549-2800x1868.jpg?fit=crop&auto=format" alt="Bottle of prednisone | Image Credit: luchschenF - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 30th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/prednisone-superior-to-other-corticosteroids-for-patients-with-copd-heart-failure">Prednisone Superior to Other Corticosteroids for Patients With COPD, Heart Failure</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/killian-meara">Killian Meara</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/prednisone-superior-to-other-corticosteroids-for-patients-with-copd-heart-failure"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Research presented at CHEST 2024 examined the effect of steroid choice on individuals who have a dual diagnosis of heart failure and chronic obstructive pulmonary disease (COPD).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/nivo-score-accurately-predicts-mortality-noninvasive-ventilation-failure-in-patients-with-aecopd"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/2c42e23593390f790c976277e12aa9bc1fbb3366-4500x3000.jpg?fit=crop&auto=format" alt="Monitoring patient's heart in the ICU | Image Credit: sudok1 - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 28th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/nivo-score-accurately-predicts-mortality-noninvasive-ventilation-failure-in-patients-with-aecopd">NIVO Score Accurately Predicts Mortality, Noninvasive Ventilation Failure in Patients With AECOPD</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/nivo-score-accurately-predicts-mortality-noninvasive-ventilation-failure-in-patients-with-aecopd"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The Noninvasive Ventilation Outcomes (NIVO) score is a reliable predictor of intensive care unit (ICU) mortality, 1-year mortality, and NIV failure in patients with acute exacerbations of COPD (AECOPD), offering valuable guidance for personalized patient management.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/interstitial-lung-abnormalities-in-patients-with-copd-linked-to-cancer-heart-failure-risks"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b68a374afda46888bad794b63a8958daa00bdfc4-4900x2593.jpg?fit=crop&auto=format" alt="Lung CT scan | Image Credit: Peakstock - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 23rd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/interstitial-lung-abnormalities-in-patients-with-copd-linked-to-cancer-heart-failure-risks">Interstitial Lung Abnormalities in Patients With COPD Linked to Cancer, Heart Failure Risks</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/interstitial-lung-abnormalities-in-patients-with-copd-linked-to-cancer-heart-failure-risks"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Interstitial lung abnormalities (ILAs) in patients with chronic obstructive pulmonary disease (COPD) are linked to lower lung adenocarcinoma rates but higher rates of other cancers and heart failure.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/ineligibility-limitations-to-pr-uptake-in-patients-with-aecopd"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6418bb32610c66a6b058609e8b3c2d21368ccb96-4200x3900.jpg?fit=crop&auto=format" alt="COPD illustration | Image Credit: peterschreiber.media - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 15th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/ineligibility-limitations-to-pr-uptake-in-patients-with-aecopd">Ineligibility, Limitations to PR Uptake in Patients With AECOPD</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/ineligibility-limitations-to-pr-uptake-in-patients-with-aecopd"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Two posters at the CHEST 2024 annual meeting revealed that 18% of eligible patients hospitalized with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) participated in post-discharge pulmonary rehabilitation (PR), with ineligibility significantly limiting uptake. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/opioids-benzodiazepines-linked-to-higher-mortality-in-older-patients-with-copd"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/0f297a51bc642231ba9807798bd6902a817ac6f0-6600x4400.jpg?fit=crop&auto=format" alt="Definition of opioids | Image Credit: Feng Yu - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 30th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/opioids-benzodiazepines-linked-to-higher-mortality-in-older-patients-with-copd">Opioids, Benzodiazepines Linked to Higher Mortality in Older Patients With COPD</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/opioids-benzodiazepines-linked-to-higher-mortality-in-older-patients-with-copd"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A study found that opioid use, with or without benzodiazepines, significantly increases long-term mortality risk in patients with chronic obstructive pulmonary disease (COPD) over the age of 60 years.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-dupilumab-as-first-biologic-treatment-for-copd"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/89980a119efbdf385fd70d29290872c0717fdf90-4743x3162.jpg?fit=crop&auto=format" alt="FDA approval stamp | Image Credit: cartoon - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-dupilumab-as-first-biologic-treatment-for-copd">FDA Approves Dupilumab as First Biologic Treatment for COPD</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-dupilumab-as-first-biologic-treatment-for-copd"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA approved dupilumab today as the first biologic treatment for patients with uncontrolled chronic obstructive pulmonary disease (COPD) and an eosinophilic phenotype to significantly help reduce exacerbations and improve lung function.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-13"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/copd-poses-public-health-risk-for-us-smokers-nonsmokers"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/52357f076f157d526c1536563d6da838936cab75-6240x4160.jpg?fit=crop&auto=format" alt="Man reaching for cigarette | Image Credit: Nopphon - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/copd-poses-public-health-risk-for-us-smokers-nonsmokers">COPD Poses Public Health Risk for US Smokers, Nonsmokers</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/copd-poses-public-health-risk-for-us-smokers-nonsmokers"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">While smoking is a key risk factor for chronic obstructive pulmonary disease (COPD), significant prevalence also exists among nonsmokers, highlighting the need for broader public health strategies.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/copd-treatment-ratio-a-measure-for-improving-copd-population-health"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/5421358c8f117ee86126333e135f08cf1e61ded6-778x382.png?fit=crop&auto=format" alt="AJMC" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 18th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/copd-treatment-ratio-a-measure-for-improving-copd-population-health">COPD Treatment Ratio: A Measure for Improving COPD Population Health</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/megha-a-parikh-phd-ms">Megha A. Parikh, PhD, MS</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/sabree-c-burbage-pharmd-mph">Sabree C. Burbage, PharmD, MPH</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/meghan-h-gabriel-phd">Meghan H. Gabriel, PhD</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ben-e-shirley-bsph">Ben E. Shirley, BSPH</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/patrick-j-campbell-pharmd-phd">Patrick J. Campbell, PharmD, PhD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/copd-treatment-ratio-a-measure-for-improving-copd-population-health"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">This article supports the use of the chronic obstructive pulmonary disease (COPD) treatment ratio as a surrogate marker of COPD exacerbation risk for quality measurement purposes.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/social-frailty-indirectly-affects-anxiety-depression-in-patients-with-aecopd-through-social-support"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/790f707cd31b95a9e55273bebaddc65a984ae7f8-4330x3464.jpg?fit=crop&auto=format" alt="Conversation drawing | Image Credit: Julien Eichinger - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 11th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/social-frailty-indirectly-affects-anxiety-depression-in-patients-with-aecopd-through-social-support">Social Frailty Indirectly Affects Anxiety, Depression in Patients With AECOPD Through Social Support</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/social-frailty-indirectly-affects-anxiety-depression-in-patients-with-aecopd-through-social-support"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Social frailty in patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) does not directly impact anxiety or depression but influences these conditions indirectly through social support.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/roflumilast-linked-to-higher-5-year-mortality-in-patients-with-copd-in-us-germany"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6937be9301868295067fa3e82c605e38db017df0-5616x3744.jpg?fit=crop&auto=format" alt="COPD drawing | Image Credit: Ivelin Radkov - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 6th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/roflumilast-linked-to-higher-5-year-mortality-in-patients-with-copd-in-us-germany">Roflumilast Linked to Higher 5-Year Mortality in Patients With COPD in US, Germany</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/roflumilast-linked-to-higher-5-year-mortality-in-patients-with-copd-in-us-germany"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A small 5-year all-cause mortality risk increase among patients with chronic obstructive pulmonary disease (COPD) using roflumilast was found in Germany and the US.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-most-patients-with-copd-remain-untreated-following-initial-diagnosis"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ce4980917cf826e939d6bf1db1bf4a77b9b5d119-4200x3900.jpg?fit=crop&auto=format" alt="COPD animation | Image Credit: peterschreiber.media - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 20th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-most-patients-with-copd-remain-untreated-following-initial-diagnosis">Study: Most Patients With COPD Remain Untreated Following Initial Diagnosis</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-most-patients-with-copd-remain-untreated-following-initial-diagnosis"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Most patients with chronic obstructive pulmonary disease (COPD) remain untreated after diagnosis, leading to frequent exacerbations.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/malnutrition-in-older-patients-with-copd-linked-to-higher-hospital-readmission-rates"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9fc2719cbc136953b83319400a226ebc507ce57b-6600x4400.jpg?fit=crop&auto=format" alt="Definition of malnutrition | Image Credit: Feng Yu - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 15th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/malnutrition-in-older-patients-with-copd-linked-to-higher-hospital-readmission-rates">Malnutrition in Older Patients With COPD Linked to Higher Hospital Readmission Rates</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/malnutrition-in-older-patients-with-copd-linked-to-higher-hospital-readmission-rates"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Malnutrition significantly increases the 180-day hospital readmission rates among patients 65 years or older with chronic obstructive pulmonary disease (COPD), highlighting the importance of monitoring and improving their nutritional status.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-19"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/medicare-advantage-program-linked-to-higher-inhaler-adherence-in-patients-with-copd"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e31acf1e89c245d612b078d5fe30d548e0c23815-4000x2667.jpg?fit=crop&auto=format" alt="Female patient using an inhaler | Image Credit: DALU11 - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 10th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/medicare-advantage-program-linked-to-higher-inhaler-adherence-in-patients-with-copd">Medicare Advantage Program Linked to Higher Inhaler Adherence in Patients With COPD</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/medicare-advantage-program-linked-to-higher-inhaler-adherence-in-patients-with-copd"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Medicare Advantage beneficiaries with chronic obstructive pulmonary disease (COPD) who were invited to enroll in a program that reduced inhaler costs and provided medication management had higher inhaler adherence; however, there was no significant impact on exacerbations or overall health care spending.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/poor-socioeconomic-status-linked-to-higher-copd-risk-in-chinese-adults-study-finds"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/94645ec783509db82032d25585a3a0c4be0e2879-5692x3795.jpg?fit=crop&auto=format" alt="Man holding an empty wallet | Image Credit: methaphum - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 7th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/poor-socioeconomic-status-linked-to-higher-copd-risk-in-chinese-adults-study-finds">Poor Socioeconomic Status Linked to Higher COPD Risk in Chinese Adults, Study Finds</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/poor-socioeconomic-status-linked-to-higher-copd-risk-in-chinese-adults-study-finds"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Chinese adults with a poor socioeconomic status are at a higher risk of developing chronic obstructive pulmonary disease (COPD).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-psoriasis-not-an-independent-risk-factor-for-copd-development"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/410d46d7ac2347a0ecc15685de43d8f5e8e1cee3-6048x4024.jpg?fit=crop&auto=format" alt="Patient with psoriasis | Image Credit: Daniel Beckemeier" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-psoriasis-not-an-independent-risk-factor-for-copd-development">Study: Psoriasis Not an Independent Risk Factor for COPD Development</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-psoriasis-not-an-independent-risk-factor-for-copd-development"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Psoriasis is not an independent risk factor for developing chronic obstructive pulmonary disease (COPD), according to a new study.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/patients-with-intellectual-disabilities-face-distinct-challenges-in-copd-asthma-care"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b7e48a9b1e2b67931327db42c03f879a57f62b3a-8256x4644.jpg?fit=crop&auto=format" alt="Female patient receiving care from general practitioner | Image Credit: bongkarn - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 22nd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-intellectual-disabilities-face-distinct-challenges-in-copd-asthma-care">Patients With Intellectual Disabilities Face Distinct Challenges in COPD, Asthma Care</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-intellectual-disabilities-face-distinct-challenges-in-copd-asthma-care"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients with intellectual disabilities experience inconsistent chronic obstructive pulmonary disease (COPD) consultations and higher rates of antibiotic prescriptions for asthma, highlighting the need for improved and tailored primary care management.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/copd-linked-to-increased-mortality-hospitalization-risk-in-patients-with-hfpef"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/0e66980af114241baadb86bbdcf2326a72450d6d-5127x3408.jpg?fit=crop&auto=format" alt="Hospital room | Image Credit: catinsyrup - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 18th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/copd-linked-to-increased-mortality-hospitalization-risk-in-patients-with-hfpef">COPD Linked to Increased Mortality, Hospitalization Risk in Patients With HFpEF</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/copd-linked-to-increased-mortality-hospitalization-risk-in-patients-with-hfpef"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Chronic obstructive pulmonary disease (COPD) significantly heightens the risk of mortality and hospitalization in patients with heart failure with preserved ejection fraction (HFpEF).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-finds-lower-copd-risk-among-patients-living-in-cities-with-fewer-than-50-000-residents"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/00c76be26cf08a7a23794042458ac61c993ae062-4500x2998.jpg?fit=crop&auto=format" alt="Cityscape | Image Credit: leungchopan - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 12th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-finds-lower-copd-risk-among-patients-living-in-cities-with-fewer-than-50-000-residents">Study Finds Lower COPD Risk Among Patients Living in Cities With Fewer Than 50,000 Residents</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-finds-lower-copd-risk-among-patients-living-in-cities-with-fewer-than-50-000-residents"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A Danish study found that living in cities with fewer than 50,000 residents and in newer, owned, and less dense homes is associated with a lower risk of developing chronic obstructive pulmonary disease (COPD).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-25"></div></div></div><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/what-we-re-reading-shrinking-drug-coverage-geriatric-care-training-investment-escalated-patent-fight"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/703de894e882d8a6da8c19964dc1ca71b969d30c-2000x1046.png?fit=crop&auto=format" alt="what we're reading logo" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 2nd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/what-we-re-reading-shrinking-drug-coverage-geriatric-care-training-investment-escalated-patent-fight">What We’re Reading: Shrinking Drug Coverage; Geriatric Care Training Investment; Escalated Patent Fight </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-staff">AJMC Staff</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/what-we-re-reading-shrinking-drug-coverage-geriatric-care-training-investment-escalated-patent-fight"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Insurers continue to raise consumer costs despite covering fewer drugs and having more drug coverage restrictions; the Biden Administration is investing hundreds of millions of dollars to train geriatricians; the Federal Trade Commission has opened an investigation into Teva Pharmaceuticals after the company refused to take down patents for its asthma and chronic obstructive pulmonary disease inhalers. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/131-million-americans-live-in-areas-with-dangerous-air-pollution-levels-report-finds"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/bb5c8962d3d6267e69d360e72dfd1c403a33d0e5-3750x2000.png?fit=crop&auto=format" alt="AJMC with Dr Munaf Siyamwala | Background image credit: ipopba - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 1st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/131-million-americans-live-in-areas-with-dangerous-air-pollution-levels-report-finds">131 Million Americans Live in Areas With Dangerous Air Pollution Levels, Report Finds</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/131-million-americans-live-in-areas-with-dangerous-air-pollution-levels-report-finds"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Based on the 2024 State of the Air report, Munaf Siyamwala, MD, of Centerpoint Medical Center, noted that patients with COPD need personalized action plans to manage flare-ups exacerbated by poor air quality and extreme weather conditions. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/heatwaves-and-high-pollution-dr-munaf-siyamwala-on-challenges-patients-with-copd-face-during-summertime"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/bb5c8962d3d6267e69d360e72dfd1c403a33d0e5-3750x2000.png?fit=crop&auto=format" alt="AJMC with Dr Munaf Siyamwala | Background image credit: ipopba - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/heatwaves-and-high-pollution-dr-munaf-siyamwala-on-challenges-patients-with-copd-face-during-summertime">Heatwaves and High Pollution: Dr Munaf Siyamwala on Challenges Patients With COPD Face During Summertime</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/heatwaves-and-high-pollution-dr-munaf-siyamwala-on-challenges-patients-with-copd-face-during-summertime"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Munaf Siyamwala, MD, of Centerpoint Medical Center, explained that summertime heatwaves and increased pollution significantly exacerbate symptoms for patients with chronic obstructive pulmonary disease (COPD).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-ensifentrine-for-maintenance-treatment-of-adult-patients-with-copd"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/8ade8751fa7d4808b277b42eb07ee01bdd7fa6d9-6000x4000.jpg?fit=crop&auto=format" alt="FDA approval | Image Credit: Olivier Le Moal - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-ensifentrine-for-maintenance-treatment-of-adult-patients-with-copd">FDA Approves Ensifentrine for Maintenance Treatment of Adult Patients With COPD</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-ensifentrine-for-maintenance-treatment-of-adult-patients-with-copd"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Today, the FDA approved ensifentrine (Ohtuvayre; Verona Pharma) for the maintenance treatment of moderate to severe chronic obstructive pulmonary disease (COPD) based on the successful phase 3 ENHANCE trials. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/high-rates-of-inhaler-misuse-found-among-patients-with-copd-using-soft-mist-inhalers"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e31acf1e89c245d612b078d5fe30d548e0c23815-4000x2667.jpg?fit=crop&auto=format" alt="Female patient using inhaler | Image Credit: DALU11 - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 12th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/high-rates-of-inhaler-misuse-found-among-patients-with-copd-using-soft-mist-inhalers">High Rates of Inhaler Misuse Found Among Patients With COPD Using Soft Mist Inhalers</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/high-rates-of-inhaler-misuse-found-among-patients-with-copd-using-soft-mist-inhalers"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Misuse of soft mist inhalers (SMIs) is common among patients with chronic obstructive pulmonary disease (COPD), particularly those with low education levels, higher symptom scores, and a shorter disease duration. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/dupilumab-improves-pre--post-bronchodilator-lung-function-measures-in-patients-with-copd-type-2-inflammation"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/dd5cd14995ae2beea9af7fe881c7fa78085b3d41-4200x3900.jpg?fit=crop&auto=format" alt="COPD cartoon | Image credit: peterschreiber.media - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 23rd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/dupilumab-improves-pre--post-bronchodilator-lung-function-measures-in-patients-with-copd-type-2-inflammation">Dupilumab Improves Pre-, Postbronchodilator Lung Function Measures in Patients With COPD, Type 2 Inflammation</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/dupilumab-improves-pre--post-bronchodilator-lung-function-measures-in-patients-with-copd-type-2-inflammation"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Two abstracts presented at the American Thoracic Society 2024 International Conference analyzed the phase 3 LIBERTY COPD BOREAS trial, finding that dupilumab improves pre- and post-bronchodilator lung function measures in patients with chronic obstructive pulmonary disease (COPD) and type 2 (T2) inflammation.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div><div class="w-full text-center flex justify-center pb-24"><a class="px-4 py-2 border-y border-r bg-primary text-white" 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In our analysis of the ","_key":"1fbe541ea7ee0"},{"text":"FLAME","_key":"47303540cab6","_type":"span","marks":["faff310667ea"]},{"marks":[],"text":" trial, we tried to see whether that's true, and our study seems to support this opinion. So, among ex-smokers, we found the anticipated association between eosinophils and treatment response. In people with low blood eosinophils, we found out that a combination of a long-acting β-agonist with a long-acting muscarinic [agonist] was superior to LABA+ICS. And then in higher blood eosinophils, we found a trend over better response to LABA+ICS compared to LABA+LAMA.","_key":"f7b522233154","_type":"span"}],"_type":"block","style":"normal","_key":"f7665a27feca"},{"markDefs":[],"children":[{"_key":"9454c6a5e209","_type":"span","marks":[],"text":"Then when we looked at groups of patients that we know from our analysis are respondents—people who have a significant suppression of their blood eosinophils on inhaled steroids—in this group of patients, in ex-smokers, LABA+ICS was superior to LABA+LAMA; that's as we would have expected. Now, when we looked at the subgroup of current smokers, LABA+LAMA was consistently superior to LABA+ICS, and that tell us that probably current smokers don't get the same benefit from inhaled corticosteroids. "}],"_type":"block","style":"normal","_key":"b21e7dc6675e"},{"children":[{"_type":"span","marks":[],"text":"","_key":"e9dc3cce188f"}],"_type":"block","style":"normal","_key":"15024918f81c","markDefs":[]},{"style":"normal","_key":"d911d37a06f8","markDefs":[],"children":[{"_key":"c6485ca197660","_type":"span","marks":["strong"],"text":"How might the findings from the FLAME trial post hoc analysis influence treatment guidelines for patients with COPD who are current smokers, particularly those with varying eosinophil counts?"}],"_type":"block"},{"_key":"8d5660666e9d","markDefs":[{"_type":"link","href":"https://ics-recode.eu/","_key":"9b8a67ada092","nofollow":true,"blank":true}],"children":[{"_type":"span","marks":[],"text":"Our post hoc analysis of the FLAME trial is an exploratory study, so we still need to validate our findings. We have a good message, but we need to further validate the results before having strong enough evidence to inform guidelines. 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","_key":"985fa7f5774b","_type":"span"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"df2750631362"}],"_type":"block","style":"normal","_key":"336605f0324e"},{"children":[{"_type":"span","marks":["em"],"text":"This transcript was lightly edited. ","_key":"4d870ec9de2a"}],"_type":"block","style":"normal","_key":"327c8b8e90c6","markDefs":[]},{"_key":"bd5b890bc8e8","markDefs":[],"children":[{"_type":"span","marks":["em"],"text":"","_key":"6863b4f2cb84"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"93225d964b3e"}],"_type":"block","style":"normal","_key":"1c073e5eb79d","markDefs":[]},{"_key":"fb5e0f8156fd","markDefs":[],"children":[{"_key":"9eef4dd9b5620","_type":"span","marks":["strong"],"text":"How does the reduction in exacerbations with itepekimab vary among former smokers with different prior exacerbation frequencies, and what might explain these differences?"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"05867ff5fb52","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Well, itepekimab is a different story; it is not addressing IL-4 [interleukin-4] or IL-13. It is addressing IL-33. We're very much dependent on epithelial biology, this is where these alarms are coming, and the data that we have so far were quite surprising in the sense that if you look at a group of individual smokers [and] nonsmokers, the signal of exacerbation reduction was much bigger in those individuals that stopped smoking compared to current smokers. So, the overall efficacy failed its primary endpoint in that trial phase 2a, but [when] looking at the nonsmokers, 50% of that population, the effects were quite sizable. ","_key":"8f04257b512d0"}]},{"style":"normal","_key":"a76baf6da5cf","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"e21ec294e31a"}],"_type":"block"},{"children":[{"text":"What is also surprising, because it's a little bit against all odds of my understanding so far, is that when we looked at these nonsmokers that have a good effect on exacerbations that group and we looked at their prior history of exacerbations in it, it didn't seem to make a difference whether you had 2 or 3 or more exacerbations. The benefit of the drug was comparable. So clinically, it means that, from the data, albeit that the smokers did not respond that well, then the nonsmokers, even if they frequently exacerbate, this drug that addresses IL-33 may be a therapeutic option in the future, and that is exciting.","_key":"fac10dbd03c8","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"f51b9046273e","markDefs":[]},{"_key":"58b5271ded37","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"bb653c63e52c"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":["strong"],"text":"What are the potential implications of these findings for tailoring COPD treatment strategies in former smokers with varying exacerbation risks?","_key":"2686ada6fd7f0"}],"_type":"block","style":"normal","_key":"23ea9b48f9cf","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"The question really of stratification of disease severity has been impairment of nonfunction at baseline, but also the risk of having exacerbation. So, it's something that that drives outcome, it drives morbidity, [and] it drives mortality. We know that. So, the prospect of having a drug available that would stimulate physicians and patients to stop smoking is one point of it. Or in more simple terms, people that have stopped smoking, you have for those individuals now an option of novel treatment on top of their regular medication. 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In both of them, about two-thirds of them had treatment-emergent adverse events, which were rather nonspecific. ","_key":"4edccb70eb480","_type":"span"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"3e13ebf1510d"}],"_type":"block","style":"normal","_key":"586707f382ec"},{"_type":"block","style":"normal","_key":"dd183beda9d2","markDefs":[],"children":[{"_type":"span","marks":[],"text":"So, both of the trials were conducted predominantly during the time of COVID. So, some of the adverse events were related to COVID-19 infections, and some of them had COPD exacerbations, which are not unanticipated events. ","_key":"1a1385ee6f5c"}]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"58fa2ddc24e2","_type":"span"}],"_type":"block","style":"normal","_key":"6b1d6af5ca24"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Other potential adverse events were nonspecific and included nasopharyngitis, headaches, and so on. They were very balanced between the treatment and the placebo group. 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He also noted that dupilumab shows promise in treating this COPD phenotype.","_key":"c260ab853fe0"}],"_type":"block","style":"normal","_key":"3b04ffcdb00e"},{"style":"normal","_key":"1df8b82c34df","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"39608e017691"}],"_type":"block"},{"_key":"914e0333a920","markDefs":[{"nofollow":false,"blank":true,"_type":"link","href":"https://www.ajmc.com/conference/ats","_key":"99a6319848d7"}],"children":[{"_key":"9c59d357007c","_type":"span","marks":[],"text":"Bhatt discussed these topics further at the "},{"_type":"span","marks":["99a6319848d7"],"text":"American Thoracic Society 2024 International Conference","_key":"bde5c375fe56"},{"_type":"span","marks":[],"text":", where he presented the phase 3 NOTUS trial results.","_key":"16f8a76573a9"}],"_type":"block","style":"normal"},{"style":"normal","_key":"31e1bfaa954b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"01381f4272ee"}],"_type":"block"},{"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"ff45e7679d3f"}],"_type":"block","style":"normal","_key":"3f430f05b4cd","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"","_key":"58d59d60930a"}],"_type":"block","style":"normal","_key":"6b049cae6c52","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"The NOTUS trial focused on patients with COPD and type 2 inflammation. Can you discuss the challenges of identifying and diagnosing this specific COPD subtype?","_key":"1bf1a1b0389f0"}],"_type":"block","style":"normal","_key":"f5c588f69ee0"},{"_type":"block","style":"normal","_key":"728b2a1a8a24","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"8e506121a05e"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The 2 ways of identifying type 2 inflammation right now are by checking blood eosinophils and making sure that the blood eosinophils are above a certain threshold, currently accepted at 300 cells per microliter. ","_key":"074134e0e7360"}],"_type":"block","style":"normal","_key":"fe6795f77bb2"},{"_type":"block","style":"normal","_key":"0bc5b51cd3b8","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"6f0d71d2f240"}]},{"_key":"692ac2f41f1a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The second way to diagnose type 2 inflammation is by using the fractional exhaled nitric oxide, or FeNO. If it's above a certain threshold, you can detect type 2 inflammation, but that was not an entry criteria in the clinical trials that were performed. ","_key":"350e17c78b22"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"6906ae605800"}],"_type":"block","style":"normal","_key":"90dbb25f8bbe"},{"children":[{"_type":"span","marks":[],"text":"The challenges with blood eosinophils are that they're not frequently on the top of everybody's mind in COPD practice right now compared to asthma, but that is likely to change. Eosinophils are already recommended by the GOLD [Global Initiative for Chronic Obstructive Lung Disease] committee, the GOLD report, to check often, to make sure that patients are being prescribed inhaled corticosteroids appropriately because people with high blood eosinophils are more likely to respond to inhaled corticosteroids. ","_key":"f9ab86da7f09"}],"_type":"block","style":"normal","_key":"936b7d1b11be","markDefs":[]},{"_type":"block","style":"normal","_key":"364e460b8a8a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"67d35961de4c"}]},{"children":[{"_type":"span","marks":[],"text":"Because there is a wide range over which they can be responsive, and because of the limited treatment options, people have not been checking blood eosinophils as often as they should. I think with new treatments coming through and becoming available, that is likely to change, and I also see a lot of colleagues already checking blood eosinophils more often. 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","_key":"51983f0fc3860"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"b0937ebd3cfe","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"da73342d4178"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"I think there is data from asthma, which may be applicable to COPD, that there are other phenotypes that can also be potentially be impacted by dupilumab and other biologics. If you think about the asthma studies, there are studies showing that using dupilumab can decrease the number of mucus plugs, it can decrease wall area thickness, it can potentially decrease the ventilation defects on MRI imaging. 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It's been increasingly recognized that about 20 to 40% of patients with COPD have type 2 inflammation, and they're more likely to suffer from repeated exacerbations. That is the reason why we're targeting patients with COPD with frequent exacerbations and type 2 inflammation with dupilumab.","_key":"2bb8ff4d7ad0"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"","_key":"a65d15206e23"}],"_type":"block","style":"normal","_key":"5b0254caf897","markDefs":[]},{"style":"normal","_key":"85882ab2b28d","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Who was the patient population in the BOREAS trial of dupilumab and what type of COPD did they have?","_key":"ecf39c8c1695"}],"_type":"block"},{"markDefs":[],"children":[{"_key":"f885a4c6d0b1","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"7bbf12ef110d"},{"markDefs":[],"children":[{"marks":[],"text":"BOREAS targeted patients with COPD with type 2 inflammation, and the main inclusion criterion were patients who were current or former smokers with at least a 10 pack/year smoking history and at high exacerbation risk, which was defined as at least 2 moderate exacerbations or 1 severe exacerbation in the previous year. 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Nationwide Children’s Hospital and co-chair of the American Thoracic Society (ATS) International Conference Committee.","_key":"c8dd620019232"}],"_type":"block","style":"normal","_key":"70d9e1cfed22"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"407bae7745620"}],"_type":"block","style":"normal","_key":"b7ccd421b4df"},{"_type":"block","style":"normal","_key":"52f315dd5144","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"6f6990af4ef40"}]},{"_key":"cda0f39f99f6","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"b5d78eb8df950"}],"_type":"block","style":"normal"},{"_key":"972eaf6ccdff","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Can you talk about the impact pediatric respiratory health has on health as an 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It's pretty clear that what happens to you as a child does have an impact on your health as an adult. There's a lot of interesting studies and data that's being presented at this conference, in fact, entire symposia that are being presented that talk about early effects, disease interventions in childhood that then lead to either improvement or worsening of disease in adulthood. Things like [chronic obstructive pulmonary disease] ","_key":"dadb2202ca6f0"},{"_type":"span","marks":["7ab90f9ffb59"],"text":"COPD","_key":"dadb2202ca6f1"},{"_key":"dadb2202ca6f2","_type":"span","marks":[],"text":", "},{"text":"asthma","_key":"2000df3c402b","_type":"span","marks":["3acaa71ee55f"]},{"_type":"span","marks":[],"text":", cystic fibrosis are just some examples of that. 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Dunn, PharmD, MBA:","_key":"1b43c2c7d3540"},{"_key":"1b43c2c7d3541","_type":"span","marks":[],"text":" Summarizing everything we’ve talked about, [give] your final thoughts. Courtney, let’s start with you."}],"_type":"block"},{"_type":"block","style":"normal","_key":"912af93270b5","markDefs":[],"children":[{"text":"","_key":"1ab9ebb413700","_type":"span","marks":[]}]},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Courtney Crim, MD:","_key":"088b452ac5e20"},{"_type":"span","marks":[],"text":" From the standpoint of managing COPD [chronic obstructive pulmonary disease], we’ve come a long way from where we were 20 or 30 years ago when we looked at it as 2 separate diseases at the end of a spectrum of chronic bronchitis and emphysema. We’ve come to recognize the comorbidities, the extrapulmonary manifestations of the disease, and we’re now addressing that. We have better therapies than we had 20 or 30 years ago through a collaboration with academia, industry, and government agencies, but there’s still a long way to go.","_key":"088b452ac5e21"}],"_type":"block","style":"normal","_key":"317d65f80b60"},{"style":"normal","_key":"26d1410c7f4c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"18696fb624890"}],"_type":"block"},{"_key":"bc0cc05334e6","markDefs":[],"children":[{"_type":"span","marks":[],"text":"We can’t reverse COPD. As Mike alluded to earlier on, if we can recognize and identify people who are at greater risk of developing COPD, even at an early age, in childhood, those who may have different trajectories as it relates to their decline in FEV1 [forced expiratory volume in 1 second] before they reach a particular stage of COPD, that would significantly advance the disease. It’s being recognized right now. People definitely are thinking about it. We need to develop these types of studies to investigate who’s at risk for it and identify people, even in early childhood, who may be at risk of developing COPD so that we can prevent the downstream effects, which is what we’re talking about today.","_key":"bc157d6fba8b0"}],"_type":"block","style":"normal"},{"_key":"5368f10c0f88","markDefs":[],"children":[{"_key":"5193896c0c640","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal"},{"style":"normal","_key":"75d5159bd815","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Jeffrey D. Dunn, PharmD, MBA:","_key":"23c10d92da1c0"},{"_type":"span","marks":[],"text":" Courtney, thank you. That was a great summary. Rey, what are your final thoughts?","_key":"23c10d92da1c1"}],"_type":"block"},{"style":"normal","_key":"cf1e6330ce62","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"1959d6ba13dd0"}],"_type":"block"},{"_type":"block","style":"normal","_key":"f805a5cd211a","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Reynold Panettieri Jr, MD: ","_key":"28721ce3dda60"},{"marks":[],"text":"This was a rich conversation, and we’ve touched on so much. I’ll leave you with 2 comments. We’re on the brink of precision medicine, but we’re not there in COPD. We’re better, but we want to move in that direction. My last comment is that we aren’t treating a disease, we’re treating a person. If we forget about the person whose disease affects them, we start to not do shared decision-making, and we don’t understand how the disease is impacting the individual and their family. The more we build that support system, the better off we are in treating a person and not a disease.","_key":"28721ce3dda61","_type":"span"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"c528608b4c520"}],"_type":"block","style":"normal","_key":"d40cc2c6c18d"},{"children":[{"_type":"span","marks":["strong"],"text":"Jeffrey D. Dunn, PharmD, MBA:","_key":"9f3b945dc69e0"},{"marks":[],"text":" Rey, thank you. Mike, last word.","_key":"9f3b945dc69e1","_type":"span"}],"_type":"block","style":"normal","_key":"7cdfac0fa607","markDefs":[]},{"_type":"block","style":"normal","_key":"b990b6b40404","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"aa85f4b2e2970"}]},{"markDefs":[],"children":[{"_key":"1427185ba6110","_type":"span","marks":["strong"],"text":"Mike Hess, MPH, RRT, RPFT:"},{"_type":"span","marks":[],"text":" Tough acts to follow, but I’ll see what I can do. The name of the game is awareness. We need to get more awareness of COPD in the clinical setting and in the general population so that people start to report symptoms earlier and understand their condition a little better. Then we can all start working together to do more research so that we can identify these people even earlier, identify all the risk factors that Courtney talked about, and continue to work together to identify ways that we can improve treatments, communication, and transitions of care. That’s what it’s going to take to get everybody working on the same page.","_key":"1427185ba6111"}],"_type":"block","style":"normal","_key":"6d8c98bda0b4"},{"markDefs":[],"children":[{"text":"","_key":"5e7d0190c4380","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"c07f72f3628d"},{"_key":"7645cb3cfcf0","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Jeffrey D. 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That’s why it’s important that we do things to keep patients out of the hospital, because that will definitely drive the cost. Those exacerbations clearly do that.","_key":"a8dd950be9ec1"}],"_type":"block","style":"normal","_key":"04e569a3f3ce"},{"markDefs":[],"children":[{"text":"","_key":"06c6fcfd5dd90","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"354508c93e05"},{"_type":"block","style":"normal","_key":"df07f240cee7","markDefs":[],"children":[{"_key":"fb7a8434b93c0","_type":"span","marks":["strong"],"text":"Jeffrey D. Dunn, PharmD, MBA:"},{"_type":"span","marks":[],"text":" I agree. Sometimes we chase our tail worrying about a few hundred dollars between cost of inhalers, when the goal is to avoid hospitalizations, ED visits, and exacerbations. Unfortunately, the pharmacy costs are what people see, and the medical cost isn’t as clear.","_key":"fb7a8434b93c1"}]},{"children":[{"_key":"73aaf39676b50","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"e1e078407def","markDefs":[]},{"style":"normal","_key":"13264c1e4743","markDefs":[],"children":[{"marks":[],"text":"What advice would you give to a payer? I’m a payer, I represent that. We’re trying to do the right thing by the patient, but we have financial issues that we have to worry about with people who use us for insurance. We have a fiduciary responsibility. Having said that, what advice would you give a payer [about] utilization or formulary management that could better drive optimal treatment of patients with COPD? 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We’d love the ability to show that on this medicine, the patient has been stable. The patient should continue on that medicine regardless of how you’ve [provided rebates for] other disease-state medications related to that sponsor or vendor. Every time an approved drug becomes a preauthorization, you put the burden on the provider and the nurses who have to go through the preauthorization.","_key":"cf4f24db10301"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"aa10d888700a","markDefs":[],"children":[{"marks":[],"text":"","_key":"3894b02b2bb30","_type":"span"}]},{"children":[{"marks":[],"text":"Second, we need to embrace new therapy quickly, as long as it’s better. For example, we don’t want to delay the opportunity to use a biologic in a space where there’s never been a biologic that has clearly showed improved outcome. That’s a big pill to swallow—no pun intended—cost-wise, but if it’s really an [impressive] drug, then let’s not wait a year to be able to approve it. Let’s move swiftly through it. Jeff, the question you raised is unbelievably difficult, and I don’t want your job.","_key":"12e7c93676e00","_type":"span"}],"_type":"block","style":"normal","_key":"7f922f8aa800","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"b1a2b753a0a90"}],"_type":"block","style":"normal","_key":"466e2c3f2695"},{"_type":"block","style":"normal","_key":"5724b130ba9f","markDefs":[],"children":[{"text":"Jeffrey D. Dunn, PharmD, MBA:","_key":"3fcac731ef210","_type":"span","marks":["strong"]},{"_type":"span","marks":[],"text":" It gives us opportunities to better coordinate, but it’s challenging. Not to go down a rabbit hole, but when we’re talking with employers or other people who are purchasing insurance, we hear “Help me manage the cost of my medications.” That’s the question we get because we’ve seen such an explosion of drug costs in this country. That’s a whole other conversation, and I don’t want to go down that rabbit hole, but there’s definitely an opportunity here for better collaboration.","_key":"3fcac731ef211"}]},{"_key":"bdfb244524d7","markDefs":[],"children":[{"_key":"560762aed57b0","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Reynold Panettieri Jr, MD: ","_key":"0f6d814024490"},{"_type":"span","marks":[],"text":"The point that you made and Courtney highlighted is really important. Health care utilization is the big-ticket item. PBMs [pharmacy benefits managers] are often separate and distinct from the other side of the equation. In managed care, in my experience, they’re siloed. They look at this cost, but they don’t look at the other side: the benefit. I suggest that the companies come together so that there’s a liaison to make the difficult choice between the 2 silos. It would make our job a lot easier.","_key":"0f6d814024491"}],"_type":"block","style":"normal","_key":"c624d87e0b7f"},{"_key":"8a6213146d60","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"3adc7e3fc8730"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Jeffrey D. Dunn, PharmD, MBA:","_key":"8d12427d7f700"},{"_type":"span","marks":[],"text":" I love that, Rey. But even in an IDN [integrated delivery network], I don’t think those things are de-siloed, generally speaking, which is frustrating. But it’s a great point. It’s data, it’s big picture. We should spend more on 1 side if it decreases overall expense and improves outcomes, but it isn’t always done. Courtney, any parting comments?","_key":"8d12427d7f701"}],"_type":"block","style":"normal","_key":"5efd0454143e"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"298d3adc12ec0"}],"_type":"block","style":"normal","_key":"5617dfbe0e2d"},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Courtney Crim, MD:","_key":"1ebc23f08b9d0"},{"_type":"span","marks":[],"text":" Rey alluded to the rabbit hole. We all recognize that the social structure of health care in the United States has major issues in terms of how we address health care in the United States. That’s a rabbit hole. When we have patients in the ICU, it’s truly a team approach from the standpoint of nursing, physicians, pharmacists, and respiratory therapists on down the line, with the goal of making the patient better. With COPD, particularly when patients are leaving the hospital or coming out of the hospital, a siloed approach where payers and practitioners can address it as a team, as opposed to everyone being concerned about their piece of the pie, would work like it does in the ICU. That doesn’t mean the cost in the ICU isn’t there, but at least everyone is working as a team for a common goal, with the patient at the center of that. We lose that in this outpatient setting, as Rey alluded to.","_key":"1ebc23f08b9d1"}],"_type":"block","style":"normal","_key":"e03d50233176"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"ac07356f49800"}],"_type":"block","style":"normal","_key":"47e30ec5196c"},{"_type":"block","style":"normal","_key":"c114a00ee919","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Jeffrey D. Dunn, PharmD, MBA:","_key":"761fbd3807930"},{"marks":[],"text":" Perfect. 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If we take the time to teach the technique or evaluate whether they can generate things like inspiratory flow, we can get a pretty good idea of whether they’re going to be able to use a particular device.","_key":"c92c0eeb58bf1","_type":"span"}],"_type":"block","style":"normal","_key":"ee4eef2fddce"},{"style":"normal","_key":"a8c4c05aff09","markDefs":[],"children":[{"text":"","_key":"c56f6036336e0","_type":"span","marks":[]}],"_type":"block"},{"_key":"ad069dcffb30","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The clinician side needs to do a better job of teaching and assessing there. The payer side needs to do a better job of listening to the clinician side when they say, “I know this person isn’t going to be able to use this medication. 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Dunn, PharmD, MBA:"},{"_type":"span","marks":[],"text":" [Summarize] the nonmedication strategies that we can use to optimize the management of COPD [chronic obstructive pulmonary disease].","_key":"4eb3064d334b1"}]},{"markDefs":[],"children":[{"_key":"06f4c35035e00","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"75b79c61d3bc"},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Mike Hess, MPH, RRT, RPFT:","_key":"d1f4fd546d6b0"},{"_type":"span","marks":[],"text":" The very first one I’ll throw out there was one [DrPanettieri","_key":"d1f4fd546d6b1"},{"_type":"span","marks":["strong"],"text":"]","_key":"d1f4fd546d6b2"},{"_type":"span","marks":[],"text":" mentioned toward the beginning: pulmonary rehabilitation. Pulmonary rehabilitation is criminally underutilized for a variety of reasons. A lot of clinicians don’t think to prescribe it, or they don’t think that their [patient] is going to be able to complete it. In certain areas, there’s a lack of available good-quality programs, but it’s one of the leading nonpharmacological therapies that we have. It speaks to the social and activity elements of it. It’s where a lot of [patients] learn how to use their inhalers properly. They learn nutrition, good exercise, those sorts of thing.","_key":"d1f4fd546d6b3"}],"_type":"block","style":"normal","_key":"cdfa5b5a43b2"},{"style":"normal","_key":"59de12c4c8ad","markDefs":[],"children":[{"marks":[],"text":"","_key":"f6efed1a72b60","_type":"span"}],"_type":"block"},{"style":"normal","_key":"bf57af51ccf9","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Right on the same level as that is, of course, treatment for tobacco [addiction] and tobacco cessation. Even after diagnosis, a lot of [patients] still struggle to quit because it’s that tenacious of an addiction. We need to make sure we’re addressing both the pharmacological and the nonpharmacological sides of that with good counseling and motivational interviewing.","_key":"85206aca62a20"}],"_type":"block"},{"_type":"block","style":"normal","_key":"b9e4eede5961","markDefs":[],"children":[{"text":"","_key":"94d545fc0a8d0","_type":"span","marks":[]}]},{"_type":"block","style":"normal","_key":"8de445cdbb80","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Jeffrey D. Dunn, PharmD, MBA:","_key":"62ae9791ebca0"},{"text":" You’re on one side and I’m on the other side, so in your opinion, how could we better work together to treat a patient? I’ve also seen situations where patients get frustrated because you’re teaching them something, we have a care manager outreach, and you’re getting information from the office. How would you see that better fitting together? We all have the same goals, but we’re coming at it from different perspectives. How can we better work together?","_key":"62ae9791ebca1","_type":"span","marks":[]}]},{"style":"normal","_key":"d790faefecd4","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"6c3ed67bd8c20"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Mike Hess, MPH, RRT, RPFT:","_key":"134bba6264100"},{"_type":"span","marks":[],"text":" It’s an issue that we see throughout the health care continuum. We talked about care coordination. As somebody is transitioning from the hospital to the home, one of the biggest breakdowns is communication. Because who’s responsibility is it at what point? It’s a complicated question with a simple, yet complicated answer: communication. We need to make sure we’re all rowing the boat together. We all need to make sure we’re talking with each other. That includes the patient and the caregiver too. We need to make sure we’re all part of a team and truly sharing those decisions together.","_key":"134bba6264101"}],"_type":"block","style":"normal","_key":"536ddd78dcca"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"3b2e58accd4b0"}],"_type":"block","style":"normal","_key":"c5e33cd854b0"},{"_type":"block","style":"normal","_key":"4dca49362bfd","markDefs":[],"children":[{"marks":["strong"],"text":"Jeffrey D. Dunn, PharmD, MBA:","_key":"69f844edf4410","_type":"span"},{"_type":"span","marks":[],"text":" We’re going to wrap up some of those formulary questions and advice to payers. I will give a plug to payers. We have data that are unavailable to other people, so we know if [patients are] filling their medications and what other doctors they’re seeing. We have a pretty good perspective of their other comorbidities. We have a responsibility to better treat these patients and, to your point, better communicate to those who are on the front lines with these patients. I put that out there to my payer colleagues. We have that responsibility. We have the data, but we need to do a better job of communicating that and coordinating care.","_key":"69f844edf4411"}]},{"_key":"52c066d8aadd","markDefs":[],"children":[{"_type":"span","marks":["strong","em"],"text":"Transcript edited for clarity.","_key":"17f276a8df76"}],"_type":"block","style":"normal"}],"title":"Role of Non-Medication Strategies in COPD Treatment Pathway","_updatedAt":"2023-01-11T21:14:53Z"}],"topArticlesData":[{"title":"Low Birth Weight Linked to Increased COPD Risk","url":"low-birth-weight-linked-to-increased-copd-risk","updatedOn":null,"source":null,"_id":"2b7d24e0-9f3b-48fb-b966-05ca9e19494d","summary":"Low birth weight is associated with an increased risk of chronic obstructive pulmonary disease (COPD), particularly among smokers, highlighting the impact of early-life factors on respiratory health.","published":"2024-12-30T14:30:00.000Z","authors":[{"displayName":"Brooke McCormick","url":"brooke-mccormick"}],"factCheckAuthors":null,"thumbnail":{"_type":"mainImage","alt":"sleeping baby in father's arms | Image Credit: BazziBa - stock.adobe.com","asset":{"_ref":"image-39bf0b85774e3e3bc2c7c0db0609203ce1085207-3248x2400-jpg","_type":"reference"}}},{"authors":[{"displayName":"Brooke McCormick","url":"brooke-mccormick"}],"url":"top-5-most-read-copd-content-of-2024","thumbnail":{"_type":"mainImage","alt":"TOP 5 COPD articles of 2024 | Image Credit: Venngage","asset":{"_ref":"image-cf2a6bd881feff86697b208db0d7e21a34ed8c67-3187x1625-png","_type":"reference"}},"updatedOn":null,"published":"2024-12-26T14:00:00.000Z","source":null,"factCheckAuthors":null,"_id":"595aeeda-810b-4e0f-973a-ba1c2f5bf404","title":"Top 5 Most-Read COPD Content of 2024","summary":"The top 5 most-read chronic obstructive pulmonary disease (COPD) articles of 2024 covered topics such as inhaled medication risks, gabapentinoid use, and the link between high white blood cell counts and exacerbations."},{"updatedOn":null,"source":null,"authors":[{"displayName":"Brooke McCormick","url":"brooke-mccormick"}],"_id":"8b30146d-44bb-490d-8845-901ab1b149ca","url":"icymi-highlights-from-chest-2024","summary":"The top 5 most-viewed content from CHEST 2024 included expert interviews and coverage on multiple areas of chest medicine.","published":"2024-12-19T14:00:00.000Z","factCheckAuthors":null,"title":"ICYMI: Highlights From CHEST 2024","thumbnail":{"alt":"CHEST 2024 highlights | Image Credit: Venngage","asset":{"_ref":"image-9d13a395da951630939c64f4980a0aa1a2ad2502-3187x1625-png","_type":"reference"},"_type":"mainImage"}},{"title":"ICYMI: Highlights From ATS 2024","thumbnail":{"_type":"mainImage","alt":"ATS 2024 highlights","asset":{"_ref":"image-c1552dea5b0f0408b01f3648d90da0020dccdb05-3187x1625-png","_type":"reference"}},"authors":[{"displayName":"Brooke McCormick","url":"brooke-mccormick"}],"updatedOn":null,"source":null,"factCheckAuthors":null,"_id":"3a4488f2-e4dd-41fd-bea0-1ec4625e8d7c","url":"icymi-highlights-from-ats-2024","summary":"The top 5 most-viewed content from this year's American Thoracic Society (ATS) 2024 International Conference featured an interview with Monica Kraft, MD, ASTF, and coverage of multiple respiratory and pulmonary medicine areas.","published":"2024-12-16T14:00:00.000Z"},{"_id":"7e524c23-fd7d-4198-9f33-4a5cb4858188","title":"COPD Linked to Increased Risk of Cognitive Impairment","url":"copd-linked-to-increased-risk-of-cognitive-impairment","thumbnail":{"_type":"mainImage","alt":"Cognitive impairment representation | Image Credit: Atlas - stock.adobe.com","asset":{"_ref":"image-af264a738f0886e7dcadca3fb8d8d0c9752160c8-6720x4480-jpg","_type":"reference"}},"published":"2024-12-12T20:15:00.000Z","updatedOn":null,"factCheckAuthors":null,"summary":"Patients with chronic obstructive pulmonary disease (COPD) are at an increased risk of cognitive impairment, with a notably higher likelihood of developing non-amnestic mild cognitive impairment.","source":null,"authors":[{"displayName":"Brooke McCormick","url":"brooke-mccormick"}]}],"features":[{"feature_title":"Type 2 Inflammation: A Common Theme Among Several Chronic Diseases ","_rev":"eXPlK0dEAMoQjxaMF6xJVM","feature_img":{"asset":{"url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/ea0f5a45cef27ee9a1d74e704d70df850372275e-492x300.png"}},"feature_alt":"Learn about the multifaceted aspects of type 2 inflammatory diseases, including impact on quality of life; 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