Julia Kaye | Gladstone Institutes

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href="/giving" class="sf-depth-1">Give</a></li> </ul> </div> </div> </div> </div> </div> </div> </div> </div> </header> </div> <div id="page-start" class="clearfix page-start"></div> <a name="main-content"></a> <div class="system-messages clearfix"> <div class="container"> <div class="row"> <div class="col-md-12"> <div class="region region-system-messages"> <div data-drupal-messages-fallback class="hidden"></div> <div class="views-element-container clearfix block block-views block-views-blockuser-admin-people-investigator-fink" id="block-views-block-user-admin-people-investigator-fink"> <div class="content"> <div><div class="view view-user-admin-people view-id-user_admin_people view-display-id-investigator_fink js-view-dom-id-ce3ec35657a9294353f4f171ef75a123c5e7be3829da9e63e07364086d2fe8f3"> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-last-name"><div class="field-content"><h1 class="page-title">Julia Kaye, PhD </h1></div></div><div class="views-field views-field-field-division"><div class="field-content"><a href="">Gladstone Center for Systems and Therapeutics </a></div></div></div> </div> <div class="view-footer"> <style> .views-field-field-division a{font-family: 'skolar-latin', serif;font-size: 18px;line-height: 20px;font-weight: bold;font-style: italic;color: white;text-decoration: none;} h1.page-title {text-transform:uppercase} </style> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="clearfix main-content region--dark-typography region--white-background region--no-separator"> <div class="clearfix main-content__container"> <div class="row"> <section> <div class="clearfix main-content__section" > <div class="region region-content"> <div id="block-showcase-lite-content" class="clearfix block block-system block-system-main-block"> <div class="content"> <article class="user user--full"> <div id="subtabs" class="subtabs"> <ul class="sudonav"> <li class="tab"><a href="#research" ><span>Research</span></a></li> <li class="tab"><a href="#about" ><span>About</span></a></li> <li class="tab"><a href="#publications" ><span>Publications</span></a></li> <li class="tab"><a href="#contact" ><span>Contact</span></a></li>  </ul> <div class="content-wrap"> <section id="research"> <div class="container"> <div class="clearfix text-formatted field field--name-field-overview field--type-text-long field--label-hidden field__item"><p>Julia Kaye, PhD, uses innovative technologies to investigate questions in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), Huntington’s disease, and Parkinson’s disease. She is an expert in induced pluripotent stem cell (iPSC) technology, specifically using patient-derived cells to produce neurons and investigate disease mechanisms. She subjects these human neuron models to an imaging approach called robotic microscopy in order to unravel how cells from patients with neurodegenerative diseases grow, behave, and survive differently from cells from healthy patients. She also applies machine learning approaches to analyze the images acquired from robotic microscopy to develop sensitive platforms that capture disease signatures. Kaye also has extensive experience in whole genome sequence analysis, and is involved in very large studies using this approach to discover how a person’s genetic makeup can modify the onset or progression of conditions including ALS, Huntington’s disease, and Parkinson’s disease. Her goal is to reveal genes that are critical in disease progression with the hopes of finding potential therapeutic targets.</p> </div> <div id="dis-tise" class="row"> <div class="col-sm-6"> <h3 class="orange">Disease Areas</h3> <div class="field field--name-field-disease-area field--type-string field--label-hidden field__items"> <div class="field__item">Huntington’s Disease</div> <div class="field__item">Amyotrophic Lateral Sclerosis</div> <div class="field__item">Parkinson’s Disease</div> </div> </div> <div class="col-sm-6"> <h3 class="orange">Areas of Expertise</h3> <div class="field field--name-field-areas-of-expertise field--type-string field--label-hidden field__items"> <div class="field__item">iPSC Disease Modeling</div> <div class="field__item">Whole Genome Sequence Analysis</div> <div class="field__item">Statistical Modeling</div> <div class="field__item">High Content Microscopy and Image Analysis Tools</div> </div> </div> </div> </div> <div class="lab-focus"> <div class="focus-img-bk"> <div class="focus-image"> <img src="/sites/default/files/user-pics/_aaa8674.jpg" alt="Working in the Kaye lab" /> </div> </div> <div class="focus-points"> <h3>Lab Focus</h3> <div class="field field--name-field-lab-focus field--type-string-long field--label-hidden field__items"> <div class="field__item">Applying iPSC technology to unravel the complexities of neurodegenerative disorders.</div> <div class="field__item">Leveraging whole genome sequencing analyses to discover genetic modifiers of disease.</div> <div class="field__item">Developing novel approaches to study images captured by robotic microscopy.</div> </div> </div> </div> <div class="container"> <div class="impact"> <h3>Research Impact</h3> <div class="clearfix text-formatted field field--name-field-research-impact field--type-text-long field--label-hidden field__item"><p>Kaye’s research focuses on using induced pluripotent stem cell (iPSC)-based models of neurological conditions to discover basic disease mechanisms. She was a founding member of the Huntington’s Disease iPSC Consortium and involved in generating some of the first patient-derived lines available to the research community. By applying longitudinal robotic microscopy to those models, she discovered disease-relevant phenotypes and provided insight into Huntington’s disease pathophysiology. Kaye has subsequently expanded this approach to investigate other neurodegenerative conditions including ALS and Parkinson’s disease. She has also used whole genome sequence analysis of family-based studies to discover novel genetic drivers and modifiers of neurodegeneration. Together, Kaye’s work is changing the understanding of the molecular drivers of neurodegenerative diseases, and is helping establish platforms that will revolutionize how we discover therapeutic targets and screen for novel drug candidates for these devastating conditions.</p> </div> </div> </div> <div> </div> <div id="related-news"> <div class="container"> <h2>Related News</h2> <div class="button-right"><a href="/news?categories=Kaye%20lab" class="button outline" tabindex="-1">Read All</a></div> <div id="owl" class="owl-carousel"> </div> </div> </div> </section> <section id="about"> <div class="container"> <div class="prof-titles"> <h3>Professional Titles</h3> <p>Research Investigator, Gladstone Institutes</p> </div> <h3>Bio</h3> <div class="clearfix text-formatted field field--name-field-bio field--type-text-long field--label-hidden field__item"><p>Julia Kaye, PhD, is a research investigator at Gladstone Institutes. She initially joined Gladstone as a postdoctoral scholar in 2009 to investigate stem cell models of neurological disease in the laboratory of Steve Finkbeiner, MD, PhD. She earned her PhD in cell and developmental biology from the University of California, Davis, where her work established paradigms of translational regulation and learned memory in C. elegans.</p> <p>Kaye’s research has revealed important insights in the basic mechanisms of Huntington’s disease and amyotrophic lateral sclerosis (ALS). She has also been involved in multiple large consortium efforts and has helped lead collaborations with industry, foundations, and NIH-funded initiatives focused on understanding disease biology and discovering therapeutic targets.</p> </div> <div class="why-gladstone"> <h3>How Did You Get Your Start in Science?</h3> <p>I got the scientific “bug” when I began using live cell imaging of chromatin in budding yeast in David Toczyski’s lab. I contributed to uncovering a novel mechanism involved in DNA double–stranded break repair that gives rise to the loss of heterozygosity in tumorigenesis. I was dazzled by the power of microscopy, and have since used it during every stage in my career to study how cells behave and unravel the pathophysiology of disease.</p> </div> <div class="why-who"> Julia Kaye, PhD </div> <h3>Honors and Awards</h3> <div class="honors-awards"> <p class="item-1 firstWord">2017–2018 Award of Excellence, Gladstone Institutes</p> <p class="item-2 firstWord">2010–2013 Postdoctoral Fellowship, California Institute of Regenerative Medicine</p> <p class="item-3 firstWord">2007–2008 Floyd and Mary Schwall Dissertation Fellowship Award, University of California, Davis</p> <p class="item-4 firstWord">2006–2009 Molecular and Cellular Biology Award, University of California, Davis</p> <div class="cntrbutt"><a class="moreawards button outline">See More</a></div> </div> </div> </section> <section id="publications"> <div class="container"> <h3>Publications</h3> <ul id="datalist"> <div id="pubitem"></div> <script> const RSS_URL = `https://fetchrss.com/rss/6102d5027b14d422fa7206b266be4302e28cc95b0d05d7e2.xml`; 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outline: none; text-transform: uppercase; font: initial; font-family: 'Proxima-Nova',Sans-serif; font-size: 14px; letter-spacing: 2px; text-decoration: none !important; white-space: nowrap; transition: all .5s ease;} #morebutt a:hover{background: #C8C8C8;} @media (max-width: 991px) { .pubitem {font-size:20px !important} } </style> </ul> </div> </section> <section id="contact"> <div class="container"> <h3> Contact</h3> <div class="row"> <div class="col-sm-7"> <p class="to-hide"><b>Julia Kaye</b><br> <a href="mailto:julia.kaye@gladstone.ucsf.edu">Email</a><br> <a href="tel:415.734.2535" title="Call" class="ph-link inv-phone">415.734.2535</a></p> <div class="investigator-assistants"> <article class="user user--compact"> <div class="user__compact"> <p> <b>Kelley Nelson</b><br>Administrative Program Manager<br> <a href="tel:415.734.2509" title="Call" class="ph-link">415.734.2509</a><br> <a href="mailto:kelley.nelson@gladstone.ucsf.edu">Email</a> </p> </div> </article> <br> </div> </div> <div class="col-sm-5" > <table class="relatedlinks"><tr> <tr><td colspan=2><a href="https://www.linkedin.com/in/julia-kaye-9a2a7729/" target="_blank"><i class="fa fa-linkedin" aria-hidden="true"></i> LinkedIn</a></td> </tr> <link rel="stylesheet" href="/themes/custom/showcase_lite/css/theme/academicons/css/academicons.min.css"> </table> </div> </div> </div> </section> <section id="labmembers"> <div class="container"> <div class="prof-titles"> <h3>Lab Members</h3> </div> <div class="row"> </div> </div> </section> </div> </div> <script src="/libraries/easytabs/jquery-1.7.1.min.js" type="text/javascript"></script> <script src="/libraries/easytabs/jquery.hashchange.min.js" type="text/javascript"></script> <script src="/libraries/easytabs/jquery.easytabs.min.js" type="text/javascript"></script> <script type="text/javascript"> $(function( $ ){ $('#subtabs').easytabs(); 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