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The T3111C polymorphism was detected by enzymatic diges-tion with Sdu I (Fermentas) and electrophoresed on MetaPhor agarose 2 % gel. The allelic and genotypic frequencies were com-pared by means of the Fisher\u0026amp;amp;amp;amp;amp;amp;#x27;s exact test. The Hardy-Weinberg equilibrium was ...","author":[{"@context":"https://schema.org","@type":"Person","name":"G. 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"https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F13557144%2FInvestigation_of_the_T3111C_CLOCK_gene_polymorphism_in_cluster_headache%3Fauto%3Ddownload"; window.loswp.translateUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F13557144%2FInvestigation_of_the_T3111C_CLOCK_gene_polymorphism_in_cluster_headache%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":45217719,"identifier":"Attachment_45217719","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":13557144,"created_at":"2015-07-02T13:25:47.890-07:00","from_world_paper_id":138569303,"updated_at":"2021-01-16T06:24:19.628-08:00","_data":{"publication_date":"2008,,","publication_name":"Journal of Neurology"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"low","language":"en","title":"Investigation of the T3111C CLOCK gene polymorphism in cluster headache","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [32744048]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":45217719,"attachmentType":"pdf"}"><img alt="First page of “Investigation of the T3111C CLOCK gene polymorphism in cluster headache”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/45217719/mini_magick20190212-14621-1cg5voy.png?1550027589" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Investigation of the T3111C CLOCK gene polymorphism in cluster headache</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="32744048" href="https://independent.academia.edu/GPierangeli"><img alt="Profile image of G. Pierangeli" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />G. Pierangeli</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2008, Journal of Neurology</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">2 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 13557144; const worksViewsPath = "/v0/works/views?subdomain_param=api&work_ids%5B%5D=13557144"; const getWorkViews = async (workId) => { const response = await fetch(worksViewsPath); if (!response.ok) { throw new Error('Failed to load work views'); } const data = await response.json(); return data.views[workId]; }; // Get the view count for the work - we send this immediately rather than waiting for // the DOM to load, so it can be available as soon as possible (but without holding up // the backend or other resource requests, because it's a bit expensive and not critical). const viewCount = await getWorkViews(workId); const updateViewCount = (viewCount) => { const viewCountBody = document.getElementById('work-metadata-view-count'); if (viewCountBody) { viewCountBody.textContent = `${viewCount} views`; } else { throw new Error('Failed to find work views element'); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":45217719,"attachmentType":"pdf","workUrl":"https://www.academia.edu/13557144/Investigation_of_the_T3111C_CLOCK_gene_polymorphism_in_cluster_headache"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":45217719,"attachmentType":"pdf","workUrl":"https://www.academia.edu/13557144/Investigation_of_the_T3111C_CLOCK_gene_polymorphism_in_cluster_headache"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="45217719" data-landing_url="https://www.academia.edu/13557144/Investigation_of_the_T3111C_CLOCK_gene_polymorphism_in_cluster_headache" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="77651732" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/77651732/PER_Gene_Family_Polymorphisms_in_Relation_to_Cluster_Headache_and_Circadian_Rhythm_in_Sweden">PER Gene Family Polymorphisms in Relation to Cluster Headache and Circadian Rhythm in Sweden</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35543884" href="https://independent.academia.edu/AndreaCarmineBelin">Andrea Carmine Belin</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Brain Sciences, 2021</p><p class="ds-related-work--abstract ds2-5-body-sm">The trigeminal autonomic cephalalgia, cluster headache (CH), is one of the most painful disorders known to man. One of the disorder’s most striking features is the reported diurnal rhythmicity of the attacks. For a majority of patients, the headache attacks occur at approximately the same time every day. Genetic variants of genes involved in the circadian rhythm such as Period Circadian Regulator 1, 2, and 3 (PER1, 2 and 3) are hypothesized to have an effect on the rhythmicity of the attacks. Six PER1, 2 and 3 genetic markers; the indel rs57875989 and five single nucleotide polymorphisms (SNPs), rs2735611, rs2304672, rs934945, rs10462020, and rs228697, were genotyped, using TaqMan® or regular polymerase chain reaction (PCR), in a Swedish CH case control material. Logistic regression showed no association between CH and any of the six genetic variants; rs57875989, p = 0.523; rs2735611, p = 0.416; rs2304672, p = 0.732; rs934945, p = 0.907; rs10462020, p = 0.726; and rs228697, p = 0.71...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"PER Gene Family Polymorphisms in Relation to Cluster Headache and Circadian Rhythm in Sweden","attachmentId":84964129,"attachmentType":"pdf","work_url":"https://www.academia.edu/77651732/PER_Gene_Family_Polymorphisms_in_Relation_to_Cluster_Headache_and_Circadian_Rhythm_in_Sweden","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/77651732/PER_Gene_Family_Polymorphisms_in_Relation_to_Cluster_Headache_and_Circadian_Rhythm_in_Sweden"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="55579589" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/55579589/Lack_of_association_between_the_3092_TC_Clock_gene_polymorphism_and_cluster_headache">Lack of association between the 3092 TC Clock gene polymorphism and cluster headache</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31892095" href="https://independent.academia.edu/InnocenzoRainero">Innocenzo Rainero</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cephalalgia, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Lack of association between the 3092 TC Clock gene polymorphism and cluster headache","attachmentId":71385925,"attachmentType":"pdf","work_url":"https://www.academia.edu/55579589/Lack_of_association_between_the_3092_TC_Clock_gene_polymorphism_and_cluster_headache","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/55579589/Lack_of_association_between_the_3092_TC_Clock_gene_polymorphism_and_cluster_headache"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="92315552" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/92315552/A_genetic_CLOCK_variant_associated_with_cluster_headache_causing_increased_mRNA_levels">A genetic CLOCK variant associated with cluster headache causing increased mRNA levels</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37718632" href="https://independent.academia.edu/AnnesofieJohansson">Anne-sofie Johansson</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cephalalgia, 2017</p><p class="ds-related-work--abstract ds2-5-body-sm">Background Cluster headache is characterized by recurrent unilateral headache attacks of severe intensity. One of the main features in a majority of patients is a striking rhythmicity of attacks. The CLOCK ( Circadian Locomotor Output Cycles Kaput) gene encodes a transcription factor that serves as a basic driving force for circadian rhythm in humans and is therefore particularly interesting as a candidate gene for cluster headache. Methods We performed an association study on a large Swedish cluster headache case-control sample (449 patients and 677 controls) screening for three single nucleotide polymorphisms (SNPs) in the CLOCK gene implicated in diurnal preference (rs1801260) or sleep duration (rs11932595 and rs12649507), respectively. We further wanted to investigate the effect of identified associated SNPs on CLOCK gene expression. Results We found a significant association with rs12649507 and cluster headache ( p = 0.0069) and this data was strengthened when stratifying for r...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A genetic CLOCK variant associated with cluster headache causing increased mRNA levels","attachmentId":95356693,"attachmentType":"pdf","work_url":"https://www.academia.edu/92315552/A_genetic_CLOCK_variant_associated_with_cluster_headache_causing_increased_mRNA_levels","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/92315552/A_genetic_CLOCK_variant_associated_with_cluster_headache_causing_increased_mRNA_levels"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="116220004" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/116220004/Candidate_gene_association_study_searching_for_genetic_factors_involved_in_migraine_chronification">Candidate-gene association study searching for genetic factors involved in migraine chronification</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="212556307" href="https://independent.academia.edu/JessicaMorantefernandez">Jessica Morante fernandez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cephalalgia, 2014</p><p class="ds-related-work--abstract ds2-5-body-sm">Introduction Chronic migraine (CM) is at the severe end of the clinical migraine spectrum, but its genetic background is unknown. Our study searched for evidence that genetic factors are involved in the chronification process. Methods We initially selected 144 single-nucleotide polymorphisms (SNPs) from 48 candidate genes, which we tested for association in two stages: The first stage encompassed 262 CM patients, the second investigated 226 patients with high-frequency migraine (HFM). Subsequently, SNPs with p values &lt; 0.05 were forwarded to the replication stage containing 531 patients with CM or HFM. Results Eight SNPs were significantly associated with CM and HFM in the two-stage phase. None survived replication in the third stage. Discussion We present the first comprehensive genetic association study for migraine chronification. There were no significant findings. Future studies may benefit from larger, genome-wide data sets or should use other genetic approaches to identify...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Candidate-gene association study searching for genetic factors involved in migraine chronification","attachmentId":112411560,"attachmentType":"pdf","work_url":"https://www.academia.edu/116220004/Candidate_gene_association_study_searching_for_genetic_factors_involved_in_migraine_chronification","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/116220004/Candidate_gene_association_study_searching_for_genetic_factors_involved_in_migraine_chronification"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="63629595" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/63629595/Circadian_rhythms_of_migraine_attacks_in_episodic_and_chronic_patients_a_cross_sectional_study_in_a_headache_center_population">Circadian rhythms of migraine attacks in episodic and chronic patients: a cross sectional study in a headache center population</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="143399645" href="https://independent.academia.edu/MariannaDelussi">Marianna Delussi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">BMC Neurology</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Circadian rhythms of migraine attacks in episodic and chronic patients: a cross sectional study in a headache center population","attachmentId":75995107,"attachmentType":"pdf","work_url":"https://www.academia.edu/63629595/Circadian_rhythms_of_migraine_attacks_in_episodic_and_chronic_patients_a_cross_sectional_study_in_a_headache_center_population","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/63629595/Circadian_rhythms_of_migraine_attacks_in_episodic_and_chronic_patients_a_cross_sectional_study_in_a_headache_center_population"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="103835671" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/103835671/Sleep_and_Chronobiology_as_a_Key_to_Understand_Cluster_Headache">Sleep and Chronobiology as a Key to Understand Cluster Headache</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="274878053" href="https://independent.academia.edu/AngeloTorrente2">Angelo Torrente</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neurology International</p><p class="ds-related-work--abstract ds2-5-body-sm">The cluster headache is a primary headache characterized by attacks of unilateral pain associated with ipsilateral cranial autonomic features. These attacks recur in clusters during the years alternating with periods of complete remission, and their onset is often during the night. This annual and nocturnal periodicity hides a strong and mysterious link among CH, sleep, chronobiology and circadian rhythm. Behind this relationship, there may be the influence of genetic components or of anatomical structures such as the hypothalamus, which are both involved in regulating the biological clock and contributing even to the periodicity of cluster headaches. The bidirectional relationship manifests itself also with the presence of sleep disturbances in patients affected by cluster headaches. What if the key to studying the physiopathology of such disease could rely on the mechanisms of chronobiology? The purpose of this review is to analyze this link in order to interpret the pathophysiolo...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Sleep and Chronobiology as a Key to Understand Cluster Headache","attachmentId":103731186,"attachmentType":"pdf","work_url":"https://www.academia.edu/103835671/Sleep_and_Chronobiology_as_a_Key_to_Understand_Cluster_Headache","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/103835671/Sleep_and_Chronobiology_as_a_Key_to_Understand_Cluster_Headache"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="56170705" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/56170705/The_molecular_clock_gene_cryptochrome_1_CRY1_and_its_role_in_cluster_headache">The molecular clock gene cryptochrome 1 (CRY1) and its role in cluster headache</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35543884" href="https://independent.academia.edu/AndreaCarmineBelin">Andrea Carmine Belin</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cephalalgia</p><p class="ds-related-work--abstract ds2-5-body-sm">Background Cluster headache is a severe primary headache disorder commonly featuring a strikingly distinct circadian attack pattern. Therefore, the circadian system has been suggested to play a crucial role in the pathophysiology of cluster headache. Cryptochromes are key components of the molecular clock generating circadian rhythms and have previously been shown to be associated with several psychiatric disorders, including seasonal affective disorder, bipolar disorder, and depression. Methods In this case-control study, we investigated the role of cryptochrome ( CRY) genes in cluster headache by screening 628 cluster headache patients and 681 controls from Sweden for four known genetic variants in the CRY1 (rs2287161 and rs8192440) and CRY2 (rs10838524 and rs1554338) genes. In addition, we analyzed CRY1 gene expression in primary fibroblast cell lines from eleven patients and ten controls. Results The exonic CRY1 variant rs8192440 was associated with cluster headache on allelic l...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The molecular clock gene cryptochrome 1 (CRY1) and its role in cluster headache","attachmentId":71688113,"attachmentType":"pdf","work_url":"https://www.academia.edu/56170705/The_molecular_clock_gene_cryptochrome_1_CRY1_and_its_role_in_cluster_headache","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/56170705/The_molecular_clock_gene_cryptochrome_1_CRY1_and_its_role_in_cluster_headache"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="24590298" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/24590298/Cluster_headache_patients_have_normal_circadian_and_sleep_time_autonomic_nervous_system_function">Cluster headache patients have normal circadian and sleep time autonomic nervous system function</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47457851" href="https://independent.academia.edu/ZvikaShinar">Zvika Shinar</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47401778" href="https://independent.academia.edu/AndaBaharav">Anda Baharav</a></div><p class="ds-related-work--metadata 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PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="25538339" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/25538339/Sleep_quality_chronotypes_and_preferential_timing_of_attacks_in_migraine_without_aura">Sleep quality, chronotypes and preferential timing of attacks in migraine without aura</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="49104929" href="https://independent.academia.edu/FabbriniMonica">Monica Fabbrini</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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Chronification","attachmentId":45972934,"attachmentType":"pdf","work_url":"https://www.academia.edu/12735181/Family_History_for_Chronic_Headache_and_Drug_Overuse_as_a_Risk_Factor_for_Headache_Chronification","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/12735181/Family_History_for_Chronic_Headache_and_Drug_Overuse_as_a_Risk_Factor_for_Headache_Chronification"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" 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