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data-props="{"color":"gray","children":["History of Life Sciences"]}" data-trace="false" data-dom-id="Pill-react-component-f774f074-51af-4b61-a2d4-a3712bf26b42"></div> <div id="Pill-react-component-f774f074-51af-4b61-a2d4-a3712bf26b42"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by J. Lafond</h3></div><div class="js-work-strip profile--work_container" data-work-id="104789971"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104789971/Trophoblast_fusion_is_induced_by_galectin_1_and_involves_the_human_endogenous_retroviral_protein_Syncytin_2"><img alt="Research paper thumbnail of Trophoblast fusion is induced by galectin-1 and involves the human endogenous retroviral protein Syncytin-2" class="work-thumbnail" src="https://attachments.academia-assets.com/104425319/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104789971/Trophoblast_fusion_is_induced_by_galectin_1_and_involves_the_human_endogenous_retroviral_protein_Syncytin_2">Trophoblast fusion is induced by galectin-1 and involves the human endogenous retroviral protein Syncytin-2</a></div><div class="wp-workCard_item"><span>Placenta</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">(IPA) were used to identify canonical signalling pathways affected by an altered O-GlcNAcome. Pul...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">(IPA) were used to identify canonical signalling pathways affected by an altered O-GlcNAcome. Pulldown and western blot were combined to verify GlcNAcylation targets. BeWo cells were used to quantify internalisation of fluorescently labelled transferrin (TF) by flow cytometry. Fluorescent TF internalisation was tracked in whole-mounted tissue explants. The accumulation of iron was observed by histology in term placental tissue. Results: The abundance of 170 GlcNAcylated proteins changed 2-fold in T2DM compared to T2CON. IPA identified clathrin-mediated endocytosis (CME) as a target pathway with x/y GlcNAc-modified proteins. Clathrin heavy chain and Rabs (small GTPases that regulate vesicular transport) were identified as targets for GlcNAcylation. CME inhibitors blocked TF internalisation. Stimulating protein O-GlcNAcylation using glucosamine (2.5mM) increased the rate of TF endocytosis in BeWo cells (p¼0.02). Furthermore, accumulation of iron, transferrin's cargo, was significantly increased in term placenta from mothers with T2DM (p¼0.01). Conclusion: This placental O-GlcNAcome is a resource to aid our understanding of the molecular mechanisms governing placental nutrient sensing. Components of the CME pathway are differentially GlcNAcylated in the T2DM placenta, suggesting altered membrane dynamics in endocytosis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="50b3807683a5d68e202baca1d203e6c7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104425319,"asset_id":104789971,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104425319/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789971"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789971"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789971; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789971]").text(description); $(".js-view-count[data-work-id=104789971]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789971; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789971']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "50b3807683a5d68e202baca1d203e6c7" } } $('.js-work-strip[data-work-id=104789971]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789971,"title":"Trophoblast fusion is induced by galectin-1 and involves the human endogenous retroviral protein Syncytin-2","internal_url":"https://www.academia.edu/104789971/Trophoblast_fusion_is_induced_by_galectin_1_and_involves_the_human_endogenous_retroviral_protein_Syncytin_2","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[{"id":104425319,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104425319/thumbnails/1.jpg","file_name":"j.placenta.2017.07.24620230721-1-cozmz4.pdf","download_url":"https://www.academia.edu/attachments/104425319/download_file","bulk_download_file_name":"Trophoblast_fusion_is_induced_by_galecti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104425319/j.placenta.2017.07.24620230721-1-cozmz4-libre.pdf?1689946944=\u0026response-content-disposition=attachment%3B+filename%3DTrophoblast_fusion_is_induced_by_galecti.pdf\u0026Expires=1739921519\u0026Signature=ek30HNc~f~yPVqpaljMpvNtixfbIlRZ4akc0xlY7qAWXH0qasY-kQlqFn~DC0vlrcWAfUV3nfdz7Eiid9W4TIqNwYwnWXnw5Qzy3aVPgkWKen0uTuygiE-HjMM6TQrX4Fsni9aeo8bOjy1A2NMI-Sv3BPNgBiqcvxAO5wJPBYUg-slaEoqDX9publH5iitosyjgS3jm1cJLBeI-euElP4thOnZMVs-iZBqjwnWweii5pKzv6jl1bybIPa53MQ1JIOQElCDiWgVNSNysbQYJNmpX9syl1guoxQGlvk3ZNBA1RWR0jy5Z7m0Yx44xT3J0MUFkvUXwy39NRjvvdNvPahA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789970"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104789970/PP2_regulates_human_trophoblast_cells_differentiation_by_activating_p38_and_ERK1_2_and_inhibiting_FAK_activation"><img alt="Research paper thumbnail of PP2 regulates human trophoblast cells differentiation by activating p38 and ERK1/2 and inhibiting FAK activation" class="work-thumbnail" src="https://attachments.academia-assets.com/104425333/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104789970/PP2_regulates_human_trophoblast_cells_differentiation_by_activating_p38_and_ERK1_2_and_inhibiting_FAK_activation">PP2 regulates human trophoblast cells differentiation by activating p38 and ERK1/2 and inhibiting FAK activation</a></div><div class="wp-workCard_item"><span>Placenta</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Throughout gestation, fetal growth and development depend, in part, on placental transfer of nutr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Throughout gestation, fetal growth and development depend, in part, on placental transfer of nutrients from the maternal circulation. This latter function depends on multinucleated, terminally differentiated syncytiotrophoblasts. In vitro, freshly isolated cytotrophoblast cells differentiate spontaneously into syncytiotrophoblast in the presence of fetal bovine serum (FBS). We have previously showed that trophoblast differentiation is regulated by ERK1/2 and p38. Moreover, we showed that PP2 [4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3, 4-d]pyrimidine], a Src family kinase (SFK) specific inhibitor, stimulates biochemical trophoblast cells differentiation while it inhibits cell adhesion and spreading without affecting cell fusion. Therefore, we examined the mechanisms by which PP2 modulates trophoblast cells differentiation. This study shows that PP2 stimulates ERK1/2 and p38 activation after 24h of treatments and up to 3 days while it inhibits focal adhesion kinase (FAK) phosph...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="801b58b61091fd8552daaaaff61ab795" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104425333,"asset_id":104789970,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104425333/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789970"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789970"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789970; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789970]").text(description); $(".js-view-count[data-work-id=104789970]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789970; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789970']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "801b58b61091fd8552daaaaff61ab795" } } $('.js-work-strip[data-work-id=104789970]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789970,"title":"PP2 regulates human trophoblast cells differentiation by activating p38 and ERK1/2 and inhibiting FAK activation","internal_url":"https://www.academia.edu/104789970/PP2_regulates_human_trophoblast_cells_differentiation_by_activating_p38_and_ERK1_2_and_inhibiting_FAK_activation","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[{"id":104425333,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104425333/thumbnails/1.jpg","file_name":"j.placenta.2008.07.01120230721-1-kix75n.pdf","download_url":"https://www.academia.edu/attachments/104425333/download_file","bulk_download_file_name":"PP2_regulates_human_trophoblast_cells_di.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104425333/j.placenta.2008.07.01120230721-1-kix75n-libre.pdf?1689946944=\u0026response-content-disposition=attachment%3B+filename%3DPP2_regulates_human_trophoblast_cells_di.pdf\u0026Expires=1739921520\u0026Signature=VwsQUeYkchoxz-iMAzexBlaf9--sCABskfgRRMFWOskoLK6CMFPLJHthCvvFo~MXyfdD1NlTqxi~mVD~aaUw9CQDkc6FniSoLoReYXxrbQ3PYSN9p2zxaDck4vtDa7NujmjJx4FY~WAiCFeFnIE76U5B2dYvdA~uE8jQQQgdrt1H-GCKSVFGXKzXvkm1Vq8suoWz3eDPLrgo36GJT8eUmtTM8OJTy0f5vVDLvuSyJZb2ac80Dh3q~pYLTe-Xc~uxv0Pv~scWOKLTZmFTHWldIdbjCQM~ugDhpNTc9D6D8wPdqVYo0HJFU9oN3yeTh6mhovK75DRQDKfR9KiZ7rFyow__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789969"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104789969/Linoleic_Acid_Transport_by_Human_Placental_Syncytiotrophoblast_Membranes"><img alt="Research paper thumbnail of Linoleic Acid Transport by Human Placental Syncytiotrophoblast Membranes" class="work-thumbnail" src="https://attachments.academia-assets.com/104425320/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104789969/Linoleic_Acid_Transport_by_Human_Placental_Syncytiotrophoblast_Membranes">Linoleic Acid Transport by Human Placental Syncytiotrophoblast Membranes</a></div><div class="wp-workCard_item"><span>European Journal of Biochemistry</span><span>, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abbreviation. Linoleic acid, ~is-cis-A~~'~-octadecadienoic acid. Enzymes. Alkaline phosphatase (E...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abbreviation. Linoleic acid, ~is-cis-A~~'~-octadecadienoic acid. Enzymes. Alkaline phosphatase (EC 3.1.3.1) ; Na+/K+-ATPase (EC 3.6.1.3). membranes [ 111, and many physiological essential functions of the fetus [12]. Some studies have demonstrated that intrauterine growth retardation could be due to a deficiency in essential fatty acids intake by the mother during pregnancy, especially in linoleic and a-linoleic acids (~is-~is-d~~'~-octadecadienoic</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="92983474d46de92836e2cac963714a18" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104425320,"asset_id":104789969,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104425320/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789969"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789969"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789969; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789969]").text(description); $(".js-view-count[data-work-id=104789969]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789969; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789969']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "92983474d46de92836e2cac963714a18" } } $('.js-work-strip[data-work-id=104789969]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789969,"title":"Linoleic Acid Transport by Human Placental Syncytiotrophoblast Membranes","internal_url":"https://www.academia.edu/104789969/Linoleic_Acid_Transport_by_Human_Placental_Syncytiotrophoblast_Membranes","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[{"id":104425320,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104425320/thumbnails/1.jpg","file_name":"j.1432-1033.1994.tb20099.x20230721-1-706t98.pdf","download_url":"https://www.academia.edu/attachments/104425320/download_file","bulk_download_file_name":"Linoleic_Acid_Transport_by_Human_Placent.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104425320/j.1432-1033.1994.tb20099.x20230721-1-706t98-libre.pdf?1689946947=\u0026response-content-disposition=attachment%3B+filename%3DLinoleic_Acid_Transport_by_Human_Placent.pdf\u0026Expires=1739921520\u0026Signature=JdotoRXPNVZTxjZVaeNz4ZLK0O-wyAiWMZpDxxLLvECHxB2CD4A8IUvrGcnErnRYbdZdAV9jp1WK92qjHBfWR7LpvYCZHnb6yUpOZi7kKeLbQGLHX2k8zTGeqpPOdrD3mykJbGViLdL0wUsxdy4I2gRRRcg8W~2QnU0LN29Xq8OslOTYWp0qfoyCP884Xku9y3YTVtjAADS7vtr1L04WD6T~wx91A-tOnYW-2U8gjygaCvOL6a9Gz3E~GltGQ0n5sm91S6Y5cXZ0LHw-Bv5k7~lIKP-WzqMMGTqjVYpUq4uXr8-OVeQ5xGsNu--x9KRqvcstk08b1i5E5ijucErywg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789968"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104789968/Calcium_Binding_Proteins_Distribution_and_Implication_in_Mammalian_Placenta"><img alt="Research paper thumbnail of Calcium-Binding Proteins : Distribution and Implication in Mammalian Placenta" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104789968/Calcium_Binding_Proteins_Distribution_and_Implication_in_Mammalian_Placenta">Calcium-Binding Proteins : Distribution and Implication in Mammalian Placenta</a></div><div class="wp-workCard_item"><span>Endocrine</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">During gestation, transport by the placenta is solely responsible for nutrient supply to the deve...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">During gestation, transport by the placenta is solely responsible for nutrient supply to the developing fetus. In this context, calcium (Ca2+) transport machinery of the placenta thus represents the primary tissue site for regulating fetal Ca2+ homeostasis. In humans, the transplacental movements of Ca2+ increase dramatically during the last trimester of gestation, when fetal skeletal mineralization is at its highest. However, little is known about the exact mechanism of transport. Evidence suggests that some developmentally expressed cytosolic Ca(2+)-binding proteins (CaBPs) have an important role in regulating or shuttling cytosolic Ca2+ since they are endowed with a high affinity for Ca2+ (approximately 10(6) M(-1)). CaBPs belong to a large family of eukaryotic proteins containing a specific helix-loop-helix structure, referred to as the EF-hand motif, which counts more than 200 members. Several of these CaBPs were identified in the placenta: CaBP9k, CaBP28k, CaBP57k, oncomodulin, S-100P, S-100alpha, and S-100beta. This review discusses the current views in this field to guide future investigations into the localization and functions of CaBPs during Ca2+ intracellular homeostasis in the placenta.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789968"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789968"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789968; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789968]").text(description); $(".js-view-count[data-work-id=104789968]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789968; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789968']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104789968]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789968,"title":"Calcium-Binding Proteins : Distribution and Implication in Mammalian Placenta","internal_url":"https://www.academia.edu/104789968/Calcium_Binding_Proteins_Distribution_and_Implication_in_Mammalian_Placenta","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789967"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104789967/Presence_of_CLA_1_and_HDL_Binding_Sites_on_Syncytiotrophoblast_Brush_Border_and_Basal_Plasma_Membranes_of_Human_Placenta"><img alt="Research paper thumbnail of Presence of CLA-1 and HDL Binding Sites on Syncytiotrophoblast Brush Border and Basal Plasma Membranes of Human Placenta" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104789967/Presence_of_CLA_1_and_HDL_Binding_Sites_on_Syncytiotrophoblast_Brush_Border_and_Basal_Plasma_Membranes_of_Human_Placenta">Presence of CLA-1 and HDL Binding Sites on Syncytiotrophoblast Brush Border and Basal Plasma Membranes of Human Placenta</a></div><div class="wp-workCard_item"><span>Placenta</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">It is now known that rapid placental and fetal development is associated with elevated levels of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">It is now known that rapid placental and fetal development is associated with elevated levels of circulating high density lipoprotein (HDL) in pregnant women. The main structure implicated in the maternal-fetal exchange is the syncytiotrophoblast, composed of a brush border membrane (BBM), facing the mother, and a basal plasma membrane (BPM), facing the fetus. In order to understand the mechanisms controlling the placental and fetal supplies of cholesterol, we purified both BBM and BPM and verified the presence of HDL binding sites in these membranes. Binding studies using(125)I-HDL(3)show a single affinity binding site on BPM which has a dissociation constant (K(d)) of 3.45+/-0.43 microg protein/ml and a maximal binding capacity (B(max)) of 5.46+/-1.69 microg protein/mg membrane proteins. In BBM, we observed two affinity binding sites, one with a K(d)of 0.62+/-0.03 microg protein/ml and another one with a K(d)of 6.57+/-0.87 microg protein/ml. Their B(max)values were 0.54+/-0.11 and 2.34+/-0.39 microg of HDL(3)/mg membrane proteins, respectively. CLA-1, a putative HDL-receptor of 85 kDa, was detected on both BPM and BBM, together with two apo A-l binding sites of 110 and 96 kDa on BPM and BBM, respectively. These results provide further evidence that human placenta possesses specific sites for HDL binding, underlining the important role of maternal HDL in the transfer of cholesterol from the maternal circulation to the placenta and the fetus.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789967"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789967"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789967; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789967]").text(description); $(".js-view-count[data-work-id=104789967]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789967; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789967']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104789967]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789967,"title":"Presence of CLA-1 and HDL Binding Sites on Syncytiotrophoblast Brush Border and Basal Plasma Membranes of Human Placenta","internal_url":"https://www.academia.edu/104789967/Presence_of_CLA_1_and_HDL_Binding_Sites_on_Syncytiotrophoblast_Brush_Border_and_Basal_Plasma_Membranes_of_Human_Placenta","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789966"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104789966/Effects_of_repeated_stimuli_on_prolactin_release_in_vitro_from_normal_and_adenomatous_rat_lactotrophs"><img alt="Research paper thumbnail of Effects of repeated stimuli on prolactin release in vitro from normal and adenomatous rat lactotrophs" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104789966/Effects_of_repeated_stimuli_on_prolactin_release_in_vitro_from_normal_and_adenomatous_rat_lactotrophs">Effects of repeated stimuli on prolactin release in vitro from normal and adenomatous rat lactotrophs</a></div><div class="wp-workCard_item"><span>Molecular and Cellular Endocrinology</span><span>, 1986</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">It is now well known that dopamine (DA) plays a major role in the inhibitory control of prolactin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">It is now well known that dopamine (DA) plays a major role in the inhibitory control of prolactin (PRL); however, the mechanisms that are physiologically involved in the stimulation of PRL release are still under investigation. Indeed, although suppression of DA inhibitory tonus, administration of thyrotropin-releasing hormone (TRH) or vasoactive intestinal peptide (VIP) are all known PRL releasers, it is not clear whether they interact during physiological periods of PRL release such as suckling and estrus. No clear indications exist, furthermore, on whether they all act upon a same pituitary pool that may become depleted following repeated exposure to stimuli. Refractoriness to a single or a repeated stimulus has been reported to occur in prolactinoma-bearing or normal humans, respectively, the mechanism of which is still matter for discussion. Our present studies performed by perifusing normal or adenomatous rat lactotrophs attached to Cytodex I microcarrier beads was undertaken to try and answer some of these questions. The experimental period consisted in perifusing the cells for 1 h with Dulbecco&amp;#39;s modified Eagle&amp;#39;s medium (DMEM) containing DA 10(-5) M, then for 2 h with either DMEM, DMEM and TRH 10(-8) M, DMEM and VIP 10(-7) M, then again with DA in DMEM for 1 h, and finally with DMEM, DMEM and TRH, or DMEM and VIP. Three experiments of various combinations were performed. Lower PRL levels were observed under DA, while two periods (first and second) of PRL release followed the suppression of DA infusion with or without the addition of either one of the two peptides.(ABSTRACT TRUNCATED AT 250 WORDS)</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789966"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789966"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789966; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789966]").text(description); $(".js-view-count[data-work-id=104789966]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789966; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789966']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104789966]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789966,"title":"Effects of repeated stimuli on prolactin release in vitro from normal and adenomatous rat lactotrophs","internal_url":"https://www.academia.edu/104789966/Effects_of_repeated_stimuli_on_prolactin_release_in_vitro_from_normal_and_adenomatous_rat_lactotrophs","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. 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Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[{"id":104425310,"title":"","file_type":"txt","scribd_thumbnail_url":"https://attachments.academia-assets.com/104425310/thumbnails/1.jpg","file_name":"84612.txt","download_url":"https://www.academia.edu/attachments/104425310/download_file","bulk_download_file_name":"Involvement_of_MAPK_Signalling_in_Human.txt","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104425310/84612.txt?1689943451=\u0026response-content-disposition=attachment%3B+filename%3DInvolvement_of_MAPK_Signalling_in_Human.txt\u0026Expires=1739890116\u0026Signature=BoUJG8qhO56nVsnsFBbAybaYKFyYs-2AF4I4008QVikgPBb7lQXq-gGyk6cTlK6d8OiNVJvYqwT57AzfZIEG5A6NJNPnpZtlWjpFjLES67sq-V6d0t1CR8dSo~qTvg9fxxpTpC~eNbFBlVi4NSkJNSkyWbh76yVj7hNAkfcmdoeO3JOevZtKNhC78HsjNvC08uhe-hUixRqG9JEZ~P23sqfvnRLE1Kgr6-RcOeGvXy2TqJzLP-m8H~eBVgFogeyfFA4orSro1MkhtahCZFnOuDbZgP8F9js32vToPB9QC7CyBBbxA6I0YGoaP-ftEiMpOdJN-tn2EgfVPrMKlq8hBg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789963"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104789963/Parathyroid_Hormone_Receptor_in_Human_Placental_Syncytiotrophoblast_Brush_Border_and_Basal_Plasma_Membranes_"><img alt="Research paper thumbnail of Parathyroid Hormone Receptor in Human Placental Syncytiotrophoblast Brush Border and Basal Plasma Membranes*" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104789963/Parathyroid_Hormone_Receptor_in_Human_Placental_Syncytiotrophoblast_Brush_Border_and_Basal_Plasma_Membranes_">Parathyroid Hormone Receptor in Human Placental Syncytiotrophoblast Brush Border and Basal Plasma Membranes*</a></div><div class="wp-workCard_item"><span>Endocrinology</span><span>, 1988</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The syncytiotrophoblast of the placenta is the site of exchange of nutrients and minerals between...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The syncytiotrophoblast of the placenta is the site of exchange of nutrients and minerals between the mother and fetus. We have recently demonstrated that PTH influences, in vitro, phosphate transport through the placenta brush border membranes (BBM) and increases cAMP accumulation in placental tissue. To demonstrate the site of binding of PTH in the cytoplasmic membrane, we have purified two polar membranes: the first located on the apical side, the BBM, and the second, on the fetal side, the basal plasma membrane (BPM). BBM were enriched 24-fold in alkaline phosphatase (marker for BBM), and the BPM was enriched 37-fold in binding of [3H] dihydroalprenolol (marker for BPM) compared to homogenate. Both placental membranes contain binding sites (maximum binding = 0.550 +/- 0.032 and 0.298 +/- 0.065 pmol/mg protein for BBM and BPM, respectively) with similar affinities (Kd = 2.05 +/- 0.23 and 1.78 +/- 0.19 nM, respectively) for 125I-[Nle8,Nle18,Tyr34] bovine (b) PTH-(1-34) amide. The three bovine preparations [bPTH-(1-34), its analog [Nle8,Nle18,Try34]bPTH-(1-34) amide, and the antagonist bPTH-(3-34)] were equipotent in binding to both placental membranes. In contrast, human PTH-(1-84) was more effective in displacing the bovine radioligand in BBM. Thyrocalcitonin and insulin, two non-PTH peptides, did not significantly displace the radioligand in BBM and BPM. Adenylate cyclase activity, located exclusively in BPM, was stimulated by PTH. Since the enzyme is absent from BBM, it is probable that the binding of the hormone to this membrane activates another system of messengers.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789963"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789963"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789963; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789963]").text(description); $(".js-view-count[data-work-id=104789963]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789963; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789963']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104789963]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789963,"title":"Parathyroid Hormone Receptor in Human Placental Syncytiotrophoblast Brush Border and Basal Plasma Membranes*","internal_url":"https://www.academia.edu/104789963/Parathyroid_Hormone_Receptor_in_Human_Placental_Syncytiotrophoblast_Brush_Border_and_Basal_Plasma_Membranes_","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789961"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104789961/Role_of_Calcium_and_Sodium_Ions_in_the_Inhibitory_Control_of_Baseline_and_Stimulated_Prolactin_Release_"><img alt="Research paper thumbnail of Role of Calcium and Sodium Ions in the Inhibitory Control of Baseline and Stimulated Prolactin Release*" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104789961/Role_of_Calcium_and_Sodium_Ions_in_the_Inhibitory_Control_of_Baseline_and_Stimulated_Prolactin_Release_">Role of Calcium and Sodium Ions in the Inhibitory Control of Baseline and Stimulated Prolactin Release*</a></div><div class="wp-workCard_item"><span>Endocrinology</span><span>, 1986</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The mechanism of dopamine (DA) inhibition of pituitary PRL release is still unclear. To study it,...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The mechanism of dopamine (DA) inhibition of pituitary PRL release is still unclear. To study it, we utilized enzymatically dispersed anterior pituitary cells obtained from adult female Sprague-Dawley rats. The cells were incubated in media with or without Na+ and in the presence or the absence of various drugs for 30 min for evaluating the secretion of PRL under baseline and experimental conditions. In some experiments, 45Ca2+ (1 microCi/ml) was added after 30 min of incubation and the latter prolonged for an additional minute to determine Ca2+ uptake. DA inhibited baseline PRL release and 45Ca2+ uptake in a dose-dependent manner only in the presence of Na+ and was totally inactive in its absence. The inhibitory effects of Nifedipine and Nicardipine, two Ca2+ channel antagonists, on PRL release were also found to be Na+ dependent. BAY K 8644, a Ca2+ channel agonist, stimulated PRL release and Ca2+ uptake in a dose-dependent manner, and these effects were enhanced by Na+-free media. DA antagonized the stimulatory actions of BAY K 8644 on PRL release in a similar dose-dependent manner both in the presence and the absence of Na+. However, on stimulated 45Ca2+ uptake DA was less effective in the absence of Na+. The stimulatory action of TRH on PRL release was enhanced by the absence of Na+. DA antagonized the effect of TRH in a dose-dependent manner both in the presence and in the absence of Na+ but appeared more effective in the absence of the ion. The PRL-releasing effects of phorbol ester and of the Ca2+ ionophore A23187 were antagonized by DA in a Na+- independent manner. These results suggest the existence of two mechanisms of DA inhibitory action: one exerted on baseline PRL release which is Na+ dependent, receptor linked, and probably implicates potential operated Ca2+ channels; the other is exerted on stimulated PRL release, is Na+ independent, and appears to be a postreceptorial intracellular event probably involving protein kinase C and/or cytosolic Ca2+ levels.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789961"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789961"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789961; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789961]").text(description); $(".js-view-count[data-work-id=104789961]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789961; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789961']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104789961]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789961,"title":"Role of Calcium and Sodium Ions in the Inhibitory Control of Baseline and Stimulated Prolactin Release*","internal_url":"https://www.academia.edu/104789961/Role_of_Calcium_and_Sodium_Ions_in_the_Inhibitory_Control_of_Baseline_and_Stimulated_Prolactin_Release_","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789960"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104789960/Site_specific_effects_of_sympathectomy_on_the_adrenergic_control_of_lipolysis_in_hamster_fat_cells"><img alt="Research paper thumbnail of Site-specific effects of sympathectomy on the adrenergic control of lipolysis in hamster fat cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104789960/Site_specific_effects_of_sympathectomy_on_the_adrenergic_control_of_lipolysis_in_hamster_fat_cells">Site-specific effects of sympathectomy on the adrenergic control of lipolysis in hamster fat cells</a></div><div class="wp-workCard_item"><span>Canadian Journal of Physiology and Pharmacology</span><span>, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Regional variations in the response of adipose tissue to lipolytic stimuli have been suggested to...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Regional variations in the response of adipose tissue to lipolytic stimuli have been suggested to be involved in the development of visceral adiposity-related morbidity and mortality. Moreover, studies in humans and in laboratory rodents such as hamsters have shown that the response of adipocytes to catecholamines depends on their anatomical origin. The aim of the present study was to investigate the relative involvement of the adrenal medulla and of the sympathetic nervous system on regional differences in the adrenergic control of lipolysis in isolated adipocytes from inguinal and epididymal adipose tissues. For this purpose, we carried out adrenal demedullation or chemical sympathectomy in hamsters. The results confirmed that epididymal adipocytes were significantly more responsive to a β-adrenergic stimulation than inguinal adipocytes (p ≤ 0.05). This site specificity could originate at a step distal to receptors since tissues exhibited a similar number of binding sites for [125...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789960"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789960"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789960; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789960]").text(description); $(".js-view-count[data-work-id=104789960]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789960; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789960']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104789960]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789960,"title":"Site-specific effects of sympathectomy on the adrenergic control of lipolysis in hamster fat cells","internal_url":"https://www.academia.edu/104789960/Site_specific_effects_of_sympathectomy_on_the_adrenergic_control_of_lipolysis_in_hamster_fat_cells","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789959"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104789959/Selective_uptake_of_cholesteryl_esters_from_various_classes_of_lipoproteins_by_HepG2_cells"><img alt="Research paper thumbnail of Selective uptake of cholesteryl esters from various classes of lipoproteins by HepG2 cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104789959/Selective_uptake_of_cholesteryl_esters_from_various_classes_of_lipoproteins_by_HepG2_cells">Selective uptake of cholesteryl esters from various classes of lipoproteins by HepG2 cells</a></div><div class="wp-workCard_item"><span>Biochemistry and Cell Biology</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Selective uptake of cholesteryl esters (CE) from lipoproteins by cells has been extensively studi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Selective uptake of cholesteryl esters (CE) from lipoproteins by cells has been extensively studied with high density lipoproteins (HDL). It is only recently that such a mechanism has been attributed to intermediate and low density lipoproteins (IDL and LDL). Here, we compare the association of proteins and CE from very low density lipoproteins (VLDL), IDL, LDL and HDL3 to HepG2 cells. These lipoproteins were either labelled in proteins with 125I or in CE with 3H-cholesteryl oleate. We show that, at any lipoprotein concentration, protein association to the cells is significantly smaller for IDL, LDL, and HDL3 than CE association, but not for VLDL. At a concentration of 20 µg lipoprotein/mL, these associations reveal CE-selective uptake in the order of 2-, 4-, and 11-fold for IDL, LDL, and HDL3, respectively. These studies reveal that LDL and HDL3 are good selective donors of CE to HepG2 cells, while IDL is a poor donor and VLDL is not a donor. A significant inverse correlation (r2 = 0.973) was found between the total lipid/protein ratios of the four classes of lipoproteins and the extent of CE-selective uptake by HepG2 cells. The fate of 3H-CE of the two best CE donors (LDL and HDL3) was followed in HepG2 cells after 3 h of incubation. Cells were shown to hydrolyze approximately 25% of the 3H-CE of both lipoproteins. However, when the cells were treated with 100 µM of chloroquine, a lysosomotropic agent, 85 and 40% of 3H-CE hydrolysis was lost for LDL and HDL3, respectively. The fate of LDL and HDL3-CE in HepG2 cells deficient in LDL-receptor was found to be the same, indicating that the portion of CE hydrolysis sensitive to chloroquine is not significantly linked to LDL-receptor activity. Thus, in HepG2 cells, the magnitude of CE-selective uptake is inversely correlated with the total lipid/protein ratios of the lipoproteins and CE-selective uptake from the two best CE donors (LDL and HDL3) appears to follow different pathways.Key words: lipoprotein, receptor, HepG2 cell, selective uptake, lipid, cholesterol, binding.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789959"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789959"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789959; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789959]").text(description); $(".js-view-count[data-work-id=104789959]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789959; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789959']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104789959]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789959,"title":"Selective uptake of cholesteryl esters from various classes of lipoproteins by HepG2 cells","internal_url":"https://www.academia.edu/104789959/Selective_uptake_of_cholesteryl_esters_from_various_classes_of_lipoproteins_by_HepG2_cells","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789939"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104789939/Influence_of_insulin_on_phosphate_uptake_by_brush_border_membranes_from_human_placenta"><img alt="Research paper thumbnail of Influence of insulin on phosphate uptake by brush border membranes from human placenta" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104789939/Influence_of_insulin_on_phosphate_uptake_by_brush_border_membranes_from_human_placenta">Influence of insulin on phosphate uptake by brush border membranes from human placenta</a></div><div class="wp-workCard_item"><span>Molecular and Cellular Endocrinology</span><span>, 1989</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Regulation of phosphate transport by insulin was investigated in brush border membranes from huma...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Regulation of phosphate transport by insulin was investigated in brush border membranes from human placenta at term. At 22 degrees C, a 45 min incubation of the total tissue with 10(-6) M insulin significantly decreased both the initial rate and the peak of sodium-dependent phosphate uptake by the corresponding brush border membranes. In contrast, Na+ transport was not influenced by the hormone. Increasing the insulin concentration from 0 to 10(-5) M resulted in a dose-dependent inhibition of phosphate uptake with half-maximal effect at 1.1 x 10(-9) M. The hormone decreased PO4 transport by decreasing the affinity of the carrier for the substrate (Km = 0.180 +/- 0.010 mM and 0.215 +/- 0.015 mM in absence and presence of 10(-6) M insulin respectively, P less than 0.05). The inhibitory effect of insulin required the presence of Mn2+ whereas neither Mn2+ nor insulin alone had any influence on PO4 uptake. It is therefore assumed that receptor phosphorylation, which needs the presence of Mn2+, is an intermediate step of insulin action on PO4 uptake by the subsequently isolated brush border membranes. In contrast, insulin had no effect on PO4 uptake when the membranes were directly incubated with the hormone prior to the transport measurement, suggesting that an intracellular messenger is needed for the inhibitory effect. This messenger is not cAMP since insulin at 10(-6) M concentration has no effect on cAMP content of the total placental tissue.(ABSTRACT TRUNCATED AT 250 WORDS)</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789939"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789939"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789939; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789939]").text(description); $(".js-view-count[data-work-id=104789939]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789939; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789939']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104789939]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789939,"title":"Influence of insulin on phosphate uptake by brush border membranes from human placenta","internal_url":"https://www.academia.edu/104789939/Influence_of_insulin_on_phosphate_uptake_by_brush_border_membranes_from_human_placenta","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="100697474"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/100697474/Effect_of_an_enriched_cholesterol_diet_during_gestation_on_fatty_acid_synthase_HMG_CoA_reductase_and_SREBP_1_2_expressions_in_rabbits"><img alt="Research paper thumbnail of Effect of an enriched cholesterol diet during gestation on fatty acid synthase, HMG-CoA reductase and SREBP-1/2 expressions in rabbits" class="work-thumbnail" src="https://attachments.academia-assets.com/101446744/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/100697474/Effect_of_an_enriched_cholesterol_diet_during_gestation_on_fatty_acid_synthase_HMG_CoA_reductase_and_SREBP_1_2_expressions_in_rabbits">Effect of an enriched cholesterol diet during gestation on fatty acid synthase, HMG-CoA reductase and SREBP-1/2 expressions in rabbits</a></div><div class="wp-workCard_item"><span>Life Sciences</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Pregnancy is associated with hyperlipidemia and hypercholesterolemia in humans. These changes tak...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Pregnancy is associated with hyperlipidemia and hypercholesterolemia in humans. These changes take place to support fetal growth and development, and modifications of these maternal concentrations may influence lipids and cholesterol synthesis in the dam, fetus and placenta. Administration of a 0.2% enriched cholesterol diet (ECD) during rabbit gestation significantly increased cholesterol and triglyceride (TG) levels in maternal livers and decreased fetal weight by 15%. Here we used Western blot analysis to examine the impact of gestation and 0.2% ECD on the expression levels of fatty acid synthase (FAS), HMGR and SREBP-1/2, which are involved in either lipid or cholesterol synthesis. We confirmed that gestation modifies the hepatic and circulating lipid profile in the mother. Our data also suggest that the maternal liver mainly supports lipogenesis, while the placenta plays a key role in cholesterol synthesis. Thus, our data demonstrate a decrease in HMGR protein levels in dam livers by feeding an ECD. In the placenta, SREBPs are highly expressed, and the ECD supplementation increased nuclear SREBP-1/2 protein levels. In addition, our results show a decrease in FAS protein levels in non-pregnant liver and in the liver of offspring from ECD-treated animals. Finally, our data suggest that the placenta does not modify its own cholesterol synthesis in response to an increase in circulating cholesterol. However, the dam liver compensates for this increase by essentially decreasing the level of HMGR expression. Because HMGR and FAS expressions do not correlate with the circulating lipid profile, it would be interesting to find which genes are then targeted by SREBP-1/2 during gestation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="34fe8ceefc5c4b3a33116c583ed8db00" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":101446744,"asset_id":100697474,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/101446744/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="100697474"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="100697474"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 100697474; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=100697474]").text(description); $(".js-view-count[data-work-id=100697474]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 100697474; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='100697474']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "34fe8ceefc5c4b3a33116c583ed8db00" } } $('.js-work-strip[data-work-id=100697474]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":100697474,"title":"Effect of an enriched cholesterol diet during gestation on fatty acid synthase, HMG-CoA reductase and SREBP-1/2 expressions in rabbits","internal_url":"https://www.academia.edu/100697474/Effect_of_an_enriched_cholesterol_diet_during_gestation_on_fatty_acid_synthase_HMG_CoA_reductase_and_SREBP_1_2_expressions_in_rabbits","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[{"id":101446744,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/101446744/thumbnails/1.jpg","file_name":"j.lfs.2007.07.01620230424-1-8ci9ta.pdf","download_url":"https://www.academia.edu/attachments/101446744/download_file","bulk_download_file_name":"Effect_of_an_enriched_cholesterol_diet_d.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/101446744/j.lfs.2007.07.01620230424-1-8ci9ta-libre.pdf?1682355616=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_an_enriched_cholesterol_diet_d.pdf\u0026Expires=1739921520\u0026Signature=TqhWqSHGO6IICUWDJRhBMC3HXbpstBUOXwlTBdOy-tDbH4VbHi5sn3N83kOPpby0a1Rd2aS7Y6jOxMr2sL7NBtS-YU8PNPi-D507ZRtDo~QUP2AQ32ALCg4AiRJ~7TqOTuHi6e2EMdw4tllr9XeuED1cjAMI-0Ycti6ufzJFCLKIqwy~XD6vzNy1zp58Bh7IaB6FZpMnxP1UvyrdXVdqeGL-VIDa07-L2qfUyXDbLqP-D4pZ9eO-aGT005ymhtWNBCL8LS7WLzysdLbgg7SjWebJqKLnyXd6vP0~k3l4-2CyU6G~pm2tcUDgO-fF5CvJOEKOvy-v~dSV48~YWewMyA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="88195360"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/88195360/Impact_of_maternal_and_neonatal_iron_status_on_placental_transferrin_receptor_expression_in_pregnant_adolescents"><img alt="Research paper thumbnail of Impact of maternal and neonatal iron status on placental transferrin receptor expression in pregnant adolescents" class="work-thumbnail" src="https://attachments.academia-assets.com/92215243/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/88195360/Impact_of_maternal_and_neonatal_iron_status_on_placental_transferrin_receptor_expression_in_pregnant_adolescents">Impact of maternal and neonatal iron status on placental transferrin receptor expression in pregnant adolescents</a></div><div class="wp-workCard_item"><span>Placenta</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective: To elucidate the role of maternal and neonatal iron status on placental transferrin re...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective: To elucidate the role of maternal and neonatal iron status on placental transferrin receptor (TfR) expression. Study design and outcomes: Ninety-two healthy pregnant adolescents (ages 14e18 years) were followed across pregnancy. Maternal iron status (hemoglobin, hematocrit, serum ferritin, TfR, and total body iron) was assessed in mid-gestation (21e25 wks) and at delivery in the mother and neonate. Placental TfR protein expression was assessed by western blot in placental tissue collected at delivery. Results: Placental TfR expression was inversely associated with maternal iron status at mid-gestation (hemoglobin p ¼ 0.046, R 2 ¼ 0.1 and hematocrit p ¼ 0.005, R 2 ¼ 0.24) and at delivery (serum ferritin p ¼ 0.02, R 2 ¼ 0.08 and total body iron p ¼ 0.02, R 2 ¼ 0.07). Mothers with depleted body iron stores had significantly greater placental expression of TfR than mothers with body iron stores greater than zero (p ¼ 0.003). Neonatal iron stores were also inversely associated with the expression of placental TfR (p ¼ 0.04, R 2 ¼ 0.06). Neonates with serum ferritin values 34 mg/L had significantly greater protein expression of placental TfR compared to neonates with cord serum ferritin values >34 mg/L (p ¼ 0.01). Conclusions: Expression of placental TfR is associated with both maternal and neonatal iron demands. Increased expression of placental TfR may be an important compensatory mechanism in response to iron deficiency in otherwise healthy pregnant women.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5e0b0556bce733414037842fe0504efb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":92215243,"asset_id":88195360,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/92215243/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="88195360"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="88195360"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 88195360; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=88195360]").text(description); $(".js-view-count[data-work-id=88195360]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 88195360; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='88195360']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5e0b0556bce733414037842fe0504efb" } } $('.js-work-strip[data-work-id=88195360]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":88195360,"title":"Impact of maternal and neonatal iron status on placental transferrin receptor expression in pregnant adolescents","internal_url":"https://www.academia.edu/88195360/Impact_of_maternal_and_neonatal_iron_status_on_placental_transferrin_receptor_expression_in_pregnant_adolescents","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[{"id":92215243,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/92215243/thumbnails/1.jpg","file_name":"j.placenta.2010.08.00920221010-1-7hah2b.pdf","download_url":"https://www.academia.edu/attachments/92215243/download_file","bulk_download_file_name":"Impact_of_maternal_and_neonatal_iron_sta.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/92215243/j.placenta.2010.08.00920221010-1-7hah2b-libre.pdf?1665365246=\u0026response-content-disposition=attachment%3B+filename%3DImpact_of_maternal_and_neonatal_iron_sta.pdf\u0026Expires=1739921520\u0026Signature=YeZeTXAzXsnYh-hkg7Fj9yyt3uMKtzW1eHgqU3u31s6QR6s1EG7~Q1EXTG23~IZr1EwqabCgorPHqBTAMhPgmIuNMHR3i8Mm8m1So3J4Sa4sYpy3EIg3OUx0ZLHb6r5xjaE9WzJbd-s9SRHLyCk-mmB343CHE1fWFU9WVT9WqENbuWCpV6f~9hKQgNNgLeAYTJyypAK4jpZMbWzr7M-UoDKDRjXcvvfgWKidYn4UOPEdlaBLh~Kyyb6CVY37GSrrIidZDl-UivH8nj~Is1XBn9OTWvbj61KZlwtwwC2sUiReEQCKCA2vmg3KRrSMqTgxY5oSKarN4YGIwpreHNKXBQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="56052644"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/56052644/Calbindin_D9k_CaBP9k_localization_and_levels_of_expression_in_trophoblast_cells_from_human_term_placenta"><img alt="Research paper thumbnail of Calbindin-D9k (CaBP9k) localization and levels of expression in trophoblast cells from human term placenta" class="work-thumbnail" src="https://attachments.academia-assets.com/71628434/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/56052644/Calbindin_D9k_CaBP9k_localization_and_levels_of_expression_in_trophoblast_cells_from_human_term_placenta">Calbindin-D9k (CaBP9k) localization and levels of expression in trophoblast cells from human term placenta</a></div><div class="wp-workCard_item"><span>Cell and Tissue Research</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">During pregnancy, the calcium (Ca 2+) transport machinery of the placenta is solely responsible f...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">During pregnancy, the calcium (Ca 2+) transport machinery of the placenta is solely responsible for the nutrient supply to the developing fetus, where active Ca 2+ transport occurs from the mother to the fetus. As part of a larger study to determine the role of Ca 2+ in placental transport in vivo, we questioned whether calbindin-D9k (CaBP9k), which is mainly expressed in duodenum, uterus, and placenta of several mammals, is present in cytotrophoblast cells and syncytiotrophoblasts of human term placenta. We were interested in this protein because of its potential importance in serving as an indicator of Ca 2+ availability and utilization in the placenta. Here, we demonstrated that CaBP9k transcript is present in both cell types, with a lower expression in cytotrophoblast cells as compared to syncytiotrophoblasts. Moreover, we showed by immunochemistry that CaBP9k protein was present in cytotrophoblast and syncytiotrophoblast placental tissue sections as well as in cultured cells. The occurrence of CaBP9k protein in trophoblast cells was further confirmed by Western blot analysis. Thus, these results indicate for the first time that CaBP9k is unequivocally expressed by trophoblast cells from human term placenta.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ef2ab56859d2d4aba8a0215e46f3c07e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71628434,"asset_id":56052644,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71628434/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="56052644"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="56052644"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 56052644; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=56052644]").text(description); $(".js-view-count[data-work-id=56052644]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 56052644; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='56052644']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ef2ab56859d2d4aba8a0215e46f3c07e" } } $('.js-work-strip[data-work-id=56052644]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":56052644,"title":"Calbindin-D9k (CaBP9k) localization and levels of expression in trophoblast cells from human term placenta","internal_url":"https://www.academia.edu/56052644/Calbindin_D9k_CaBP9k_localization_and_levels_of_expression_in_trophoblast_cells_from_human_term_placenta","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[{"id":71628434,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71628434/thumbnails/1.jpg","file_name":"s00441-003-0811-420211006-10629-1ymdq1.pdf","download_url":"https://www.academia.edu/attachments/71628434/download_file","bulk_download_file_name":"Calbindin_D9k_CaBP9k_localization_and_le.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71628434/s00441-003-0811-420211006-10629-1ymdq1-libre.pdf?1635228957=\u0026response-content-disposition=attachment%3B+filename%3DCalbindin_D9k_CaBP9k_localization_and_le.pdf\u0026Expires=1739921520\u0026Signature=YrLXyiC-wEpnSoF6U85lNkrF0-DwElZS-xvR~xeE7PPIeiGvNDEUD86NPW2XoGhemWoPf1w7hMeT1-KfZ-k7iArWrQw9R-yNKAHPJBlMk4-zH75H98HIb3FDwDQZbJaec578oJmhvCSvt-V9gNh9w-tGZZqdiMu-SjfcM02161iYEHgUNFyjKzSbVpty4XaSDtbocc7MTAAS8GnNLbk0zp9PhEJfj68DC~NeuawyxmTqnFV1aI9TkBWWPYz4emNHAhPoAgwANhm2CiuQhStj58LoqL9avjYMesD8lcKs4t8ZpinpNbaXsq7Fr~-UCIRbMDDotXdQrtjPgRk1L0vOPQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="11744394"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/11744394/Calcitonin_receptor_in_human_placental_syncytiotrophoblast_brush_border_and_basal_plasma_membranes"><img alt="Research paper thumbnail of Calcitonin receptor in human placental syncytiotrophoblast brush border and basal plasma membranes" class="work-thumbnail" src="https://attachments.academia-assets.com/46549189/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/11744394/Calcitonin_receptor_in_human_placental_syncytiotrophoblast_brush_border_and_basal_plasma_membranes">Calcitonin receptor in human placental syncytiotrophoblast brush border and basal plasma membranes</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/DanielLajeunesse">Daniel Lajeunesse</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/JLafond">J. Lafond</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We wish to make amendments in three places:</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7a8ab6083de0f7702d845dc80efd3d1a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46549189,"asset_id":11744394,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46549189/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="11744394"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="11744394"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 11744394; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=11744394]").text(description); $(".js-view-count[data-work-id=11744394]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 11744394; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='11744394']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="22611321"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/22611321/Environmental_exposure_to_cadmium_and_human_birthweight"><img alt="Research paper thumbnail of Environmental exposure to cadmium and human birthweight" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/22611321/Environmental_exposure_to_cadmium_and_human_birthweight">Environmental exposure to cadmium and human birthweight</a></div><div class="wp-workCard_item"><span>Toxicology</span><span>, 1993</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Fetal toxicity of cadmium (Cd) is well documented in rodents. However, little information is avai...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Fetal toxicity of cadmium (Cd) is well documented in rodents. However, little information is available regarding the human fetus. To investigate the effect of low levels of Cd on the human placenta and the consequences on birthweight, we conducted a study of 102 mothers and their newborns in an obstetrical care unit. Placental and hair samples were collected at delivery to determine Cd concentrations. The main finding of this study was the relationship between a decrease in birthweight and an increase of newborn hair Cd which varied in the presence of placental calcification. In cases of parenchymal calcifications, placental Cd levels were higher (Wilcoxon test, P &amp;lt; 0.05) and newborn hair Cd levels were lower (Wilcoxon test, P &amp;lt; 0.01) than in the absence of calcification. These relationships remained significant even after taking into account smoking habits and gestational age. In the presence of calcification, an increase in the level of Cd in newborn hair was related to a decrease in birthweight which was independent of placental Cd concentration (rpartial = -0.49, P &amp;lt; 0.01). In the absence of calcification, a decrease in birthweight was observed for the upper values of newborn hair Cd (r = -0.44, P &amp;lt; 0.05 when Cd &amp;gt; or = 0.3 ppm). The difference in birthweight between infants in the first and last quartiles of newborn hair Cd was 472 g in cases of calcifications and 122 g in the absence of calcification. Other placental parameters were not significantly related to placental Cd concentration.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="22611321"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="22611321"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22611321; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22611321]").text(description); $(".js-view-count[data-work-id=22611321]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22611321; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='22611321']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=22611321]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":22611321,"title":"Environmental exposure to cadmium and human birthweight","internal_url":"https://www.academia.edu/22611321/Environmental_exposure_to_cadmium_and_human_birthweight","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="22611286"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/22611286/Maternal_fetal_calcium_transfer"><img alt="Research paper thumbnail of Maternal- fetal calcium transfer" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/22611286/Maternal_fetal_calcium_transfer">Maternal- fetal calcium transfer</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="22611286"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="22611286"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22611286; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22611286]").text(description); $(".js-view-count[data-work-id=22611286]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22611286; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='22611286']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=22611286]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":22611286,"title":"Maternal- fetal calcium transfer","internal_url":"https://www.academia.edu/22611286/Maternal_fetal_calcium_transfer","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. 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Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3526705" id="papers"><div class="js-work-strip profile--work_container" data-work-id="104789971"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104789971/Trophoblast_fusion_is_induced_by_galectin_1_and_involves_the_human_endogenous_retroviral_protein_Syncytin_2"><img alt="Research paper thumbnail of Trophoblast fusion is induced by galectin-1 and involves the human endogenous retroviral protein Syncytin-2" class="work-thumbnail" src="https://attachments.academia-assets.com/104425319/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104789971/Trophoblast_fusion_is_induced_by_galectin_1_and_involves_the_human_endogenous_retroviral_protein_Syncytin_2">Trophoblast fusion is induced by galectin-1 and involves the human endogenous retroviral protein Syncytin-2</a></div><div class="wp-workCard_item"><span>Placenta</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">(IPA) were used to identify canonical signalling pathways affected by an altered O-GlcNAcome. Pul...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">(IPA) were used to identify canonical signalling pathways affected by an altered O-GlcNAcome. Pulldown and western blot were combined to verify GlcNAcylation targets. BeWo cells were used to quantify internalisation of fluorescently labelled transferrin (TF) by flow cytometry. Fluorescent TF internalisation was tracked in whole-mounted tissue explants. The accumulation of iron was observed by histology in term placental tissue. Results: The abundance of 170 GlcNAcylated proteins changed 2-fold in T2DM compared to T2CON. IPA identified clathrin-mediated endocytosis (CME) as a target pathway with x/y GlcNAc-modified proteins. Clathrin heavy chain and Rabs (small GTPases that regulate vesicular transport) were identified as targets for GlcNAcylation. CME inhibitors blocked TF internalisation. Stimulating protein O-GlcNAcylation using glucosamine (2.5mM) increased the rate of TF endocytosis in BeWo cells (p¼0.02). Furthermore, accumulation of iron, transferrin's cargo, was significantly increased in term placenta from mothers with T2DM (p¼0.01). Conclusion: This placental O-GlcNAcome is a resource to aid our understanding of the molecular mechanisms governing placental nutrient sensing. Components of the CME pathway are differentially GlcNAcylated in the T2DM placenta, suggesting altered membrane dynamics in endocytosis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="50b3807683a5d68e202baca1d203e6c7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104425319,"asset_id":104789971,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104425319/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789971"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789971"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789971; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789971]").text(description); $(".js-view-count[data-work-id=104789971]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789971; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789971']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "50b3807683a5d68e202baca1d203e6c7" } } $('.js-work-strip[data-work-id=104789971]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789971,"title":"Trophoblast fusion is induced by galectin-1 and involves the human endogenous retroviral protein Syncytin-2","internal_url":"https://www.academia.edu/104789971/Trophoblast_fusion_is_induced_by_galectin_1_and_involves_the_human_endogenous_retroviral_protein_Syncytin_2","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[{"id":104425319,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104425319/thumbnails/1.jpg","file_name":"j.placenta.2017.07.24620230721-1-cozmz4.pdf","download_url":"https://www.academia.edu/attachments/104425319/download_file","bulk_download_file_name":"Trophoblast_fusion_is_induced_by_galecti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104425319/j.placenta.2017.07.24620230721-1-cozmz4-libre.pdf?1689946944=\u0026response-content-disposition=attachment%3B+filename%3DTrophoblast_fusion_is_induced_by_galecti.pdf\u0026Expires=1739921519\u0026Signature=ek30HNc~f~yPVqpaljMpvNtixfbIlRZ4akc0xlY7qAWXH0qasY-kQlqFn~DC0vlrcWAfUV3nfdz7Eiid9W4TIqNwYwnWXnw5Qzy3aVPgkWKen0uTuygiE-HjMM6TQrX4Fsni9aeo8bOjy1A2NMI-Sv3BPNgBiqcvxAO5wJPBYUg-slaEoqDX9publH5iitosyjgS3jm1cJLBeI-euElP4thOnZMVs-iZBqjwnWweii5pKzv6jl1bybIPa53MQ1JIOQElCDiWgVNSNysbQYJNmpX9syl1guoxQGlvk3ZNBA1RWR0jy5Z7m0Yx44xT3J0MUFkvUXwy39NRjvvdNvPahA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789970"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104789970/PP2_regulates_human_trophoblast_cells_differentiation_by_activating_p38_and_ERK1_2_and_inhibiting_FAK_activation"><img alt="Research paper thumbnail of PP2 regulates human trophoblast cells differentiation by activating p38 and ERK1/2 and inhibiting FAK activation" class="work-thumbnail" src="https://attachments.academia-assets.com/104425333/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104789970/PP2_regulates_human_trophoblast_cells_differentiation_by_activating_p38_and_ERK1_2_and_inhibiting_FAK_activation">PP2 regulates human trophoblast cells differentiation by activating p38 and ERK1/2 and inhibiting FAK activation</a></div><div class="wp-workCard_item"><span>Placenta</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Throughout gestation, fetal growth and development depend, in part, on placental transfer of nutr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Throughout gestation, fetal growth and development depend, in part, on placental transfer of nutrients from the maternal circulation. This latter function depends on multinucleated, terminally differentiated syncytiotrophoblasts. In vitro, freshly isolated cytotrophoblast cells differentiate spontaneously into syncytiotrophoblast in the presence of fetal bovine serum (FBS). We have previously showed that trophoblast differentiation is regulated by ERK1/2 and p38. Moreover, we showed that PP2 [4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3, 4-d]pyrimidine], a Src family kinase (SFK) specific inhibitor, stimulates biochemical trophoblast cells differentiation while it inhibits cell adhesion and spreading without affecting cell fusion. Therefore, we examined the mechanisms by which PP2 modulates trophoblast cells differentiation. This study shows that PP2 stimulates ERK1/2 and p38 activation after 24h of treatments and up to 3 days while it inhibits focal adhesion kinase (FAK) phosph...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="801b58b61091fd8552daaaaff61ab795" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104425333,"asset_id":104789970,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104425333/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789970"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789970"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789970; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789970]").text(description); $(".js-view-count[data-work-id=104789970]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789970; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789970']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "801b58b61091fd8552daaaaff61ab795" } } $('.js-work-strip[data-work-id=104789970]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789970,"title":"PP2 regulates human trophoblast cells differentiation by activating p38 and ERK1/2 and inhibiting FAK activation","internal_url":"https://www.academia.edu/104789970/PP2_regulates_human_trophoblast_cells_differentiation_by_activating_p38_and_ERK1_2_and_inhibiting_FAK_activation","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[{"id":104425333,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104425333/thumbnails/1.jpg","file_name":"j.placenta.2008.07.01120230721-1-kix75n.pdf","download_url":"https://www.academia.edu/attachments/104425333/download_file","bulk_download_file_name":"PP2_regulates_human_trophoblast_cells_di.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104425333/j.placenta.2008.07.01120230721-1-kix75n-libre.pdf?1689946944=\u0026response-content-disposition=attachment%3B+filename%3DPP2_regulates_human_trophoblast_cells_di.pdf\u0026Expires=1739921520\u0026Signature=VwsQUeYkchoxz-iMAzexBlaf9--sCABskfgRRMFWOskoLK6CMFPLJHthCvvFo~MXyfdD1NlTqxi~mVD~aaUw9CQDkc6FniSoLoReYXxrbQ3PYSN9p2zxaDck4vtDa7NujmjJx4FY~WAiCFeFnIE76U5B2dYvdA~uE8jQQQgdrt1H-GCKSVFGXKzXvkm1Vq8suoWz3eDPLrgo36GJT8eUmtTM8OJTy0f5vVDLvuSyJZb2ac80Dh3q~pYLTe-Xc~uxv0Pv~scWOKLTZmFTHWldIdbjCQM~ugDhpNTc9D6D8wPdqVYo0HJFU9oN3yeTh6mhovK75DRQDKfR9KiZ7rFyow__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789969"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104789969/Linoleic_Acid_Transport_by_Human_Placental_Syncytiotrophoblast_Membranes"><img alt="Research paper thumbnail of Linoleic Acid Transport by Human Placental Syncytiotrophoblast Membranes" class="work-thumbnail" src="https://attachments.academia-assets.com/104425320/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104789969/Linoleic_Acid_Transport_by_Human_Placental_Syncytiotrophoblast_Membranes">Linoleic Acid Transport by Human Placental Syncytiotrophoblast Membranes</a></div><div class="wp-workCard_item"><span>European Journal of Biochemistry</span><span>, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abbreviation. Linoleic acid, ~is-cis-A~~'~-octadecadienoic acid. Enzymes. Alkaline phosphatase (E...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abbreviation. Linoleic acid, ~is-cis-A~~'~-octadecadienoic acid. Enzymes. Alkaline phosphatase (EC 3.1.3.1) ; Na+/K+-ATPase (EC 3.6.1.3). membranes [ 111, and many physiological essential functions of the fetus [12]. Some studies have demonstrated that intrauterine growth retardation could be due to a deficiency in essential fatty acids intake by the mother during pregnancy, especially in linoleic and a-linoleic acids (~is-~is-d~~'~-octadecadienoic</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="92983474d46de92836e2cac963714a18" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104425320,"asset_id":104789969,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104425320/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789969"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789969"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789969; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789969]").text(description); $(".js-view-count[data-work-id=104789969]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789969; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789969']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "92983474d46de92836e2cac963714a18" } } $('.js-work-strip[data-work-id=104789969]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789969,"title":"Linoleic Acid Transport by Human Placental Syncytiotrophoblast Membranes","internal_url":"https://www.academia.edu/104789969/Linoleic_Acid_Transport_by_Human_Placental_Syncytiotrophoblast_Membranes","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[{"id":104425320,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104425320/thumbnails/1.jpg","file_name":"j.1432-1033.1994.tb20099.x20230721-1-706t98.pdf","download_url":"https://www.academia.edu/attachments/104425320/download_file","bulk_download_file_name":"Linoleic_Acid_Transport_by_Human_Placent.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104425320/j.1432-1033.1994.tb20099.x20230721-1-706t98-libre.pdf?1689946947=\u0026response-content-disposition=attachment%3B+filename%3DLinoleic_Acid_Transport_by_Human_Placent.pdf\u0026Expires=1739921520\u0026Signature=JdotoRXPNVZTxjZVaeNz4ZLK0O-wyAiWMZpDxxLLvECHxB2CD4A8IUvrGcnErnRYbdZdAV9jp1WK92qjHBfWR7LpvYCZHnb6yUpOZi7kKeLbQGLHX2k8zTGeqpPOdrD3mykJbGViLdL0wUsxdy4I2gRRRcg8W~2QnU0LN29Xq8OslOTYWp0qfoyCP884Xku9y3YTVtjAADS7vtr1L04WD6T~wx91A-tOnYW-2U8gjygaCvOL6a9Gz3E~GltGQ0n5sm91S6Y5cXZ0LHw-Bv5k7~lIKP-WzqMMGTqjVYpUq4uXr8-OVeQ5xGsNu--x9KRqvcstk08b1i5E5ijucErywg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789968"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104789968/Calcium_Binding_Proteins_Distribution_and_Implication_in_Mammalian_Placenta"><img alt="Research paper thumbnail of Calcium-Binding Proteins : Distribution and Implication in Mammalian Placenta" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104789968/Calcium_Binding_Proteins_Distribution_and_Implication_in_Mammalian_Placenta">Calcium-Binding Proteins : Distribution and Implication in Mammalian Placenta</a></div><div class="wp-workCard_item"><span>Endocrine</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">During gestation, transport by the placenta is solely responsible for nutrient supply to the deve...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">During gestation, transport by the placenta is solely responsible for nutrient supply to the developing fetus. In this context, calcium (Ca2+) transport machinery of the placenta thus represents the primary tissue site for regulating fetal Ca2+ homeostasis. In humans, the transplacental movements of Ca2+ increase dramatically during the last trimester of gestation, when fetal skeletal mineralization is at its highest. However, little is known about the exact mechanism of transport. Evidence suggests that some developmentally expressed cytosolic Ca(2+)-binding proteins (CaBPs) have an important role in regulating or shuttling cytosolic Ca2+ since they are endowed with a high affinity for Ca2+ (approximately 10(6) M(-1)). CaBPs belong to a large family of eukaryotic proteins containing a specific helix-loop-helix structure, referred to as the EF-hand motif, which counts more than 200 members. Several of these CaBPs were identified in the placenta: CaBP9k, CaBP28k, CaBP57k, oncomodulin, S-100P, S-100alpha, and S-100beta. This review discusses the current views in this field to guide future investigations into the localization and functions of CaBPs during Ca2+ intracellular homeostasis in the placenta.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789968"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789968"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789968; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789968]").text(description); $(".js-view-count[data-work-id=104789968]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789968; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789968']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104789968]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789968,"title":"Calcium-Binding Proteins : Distribution and Implication in Mammalian Placenta","internal_url":"https://www.academia.edu/104789968/Calcium_Binding_Proteins_Distribution_and_Implication_in_Mammalian_Placenta","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789967"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104789967/Presence_of_CLA_1_and_HDL_Binding_Sites_on_Syncytiotrophoblast_Brush_Border_and_Basal_Plasma_Membranes_of_Human_Placenta"><img alt="Research paper thumbnail of Presence of CLA-1 and HDL Binding Sites on Syncytiotrophoblast Brush Border and Basal Plasma Membranes of Human Placenta" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104789967/Presence_of_CLA_1_and_HDL_Binding_Sites_on_Syncytiotrophoblast_Brush_Border_and_Basal_Plasma_Membranes_of_Human_Placenta">Presence of CLA-1 and HDL Binding Sites on Syncytiotrophoblast Brush Border and Basal Plasma Membranes of Human Placenta</a></div><div class="wp-workCard_item"><span>Placenta</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">It is now known that rapid placental and fetal development is associated with elevated levels of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">It is now known that rapid placental and fetal development is associated with elevated levels of circulating high density lipoprotein (HDL) in pregnant women. The main structure implicated in the maternal-fetal exchange is the syncytiotrophoblast, composed of a brush border membrane (BBM), facing the mother, and a basal plasma membrane (BPM), facing the fetus. In order to understand the mechanisms controlling the placental and fetal supplies of cholesterol, we purified both BBM and BPM and verified the presence of HDL binding sites in these membranes. Binding studies using(125)I-HDL(3)show a single affinity binding site on BPM which has a dissociation constant (K(d)) of 3.45+/-0.43 microg protein/ml and a maximal binding capacity (B(max)) of 5.46+/-1.69 microg protein/mg membrane proteins. In BBM, we observed two affinity binding sites, one with a K(d)of 0.62+/-0.03 microg protein/ml and another one with a K(d)of 6.57+/-0.87 microg protein/ml. Their B(max)values were 0.54+/-0.11 and 2.34+/-0.39 microg of HDL(3)/mg membrane proteins, respectively. CLA-1, a putative HDL-receptor of 85 kDa, was detected on both BPM and BBM, together with two apo A-l binding sites of 110 and 96 kDa on BPM and BBM, respectively. These results provide further evidence that human placenta possesses specific sites for HDL binding, underlining the important role of maternal HDL in the transfer of cholesterol from the maternal circulation to the placenta and the fetus.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789967"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789967"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789967; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789967]").text(description); $(".js-view-count[data-work-id=104789967]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789967; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789967']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104789967]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789967,"title":"Presence of CLA-1 and HDL Binding Sites on Syncytiotrophoblast Brush Border and Basal Plasma Membranes of Human Placenta","internal_url":"https://www.academia.edu/104789967/Presence_of_CLA_1_and_HDL_Binding_Sites_on_Syncytiotrophoblast_Brush_Border_and_Basal_Plasma_Membranes_of_Human_Placenta","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789966"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104789966/Effects_of_repeated_stimuli_on_prolactin_release_in_vitro_from_normal_and_adenomatous_rat_lactotrophs"><img alt="Research paper thumbnail of Effects of repeated stimuli on prolactin release in vitro from normal and adenomatous rat lactotrophs" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104789966/Effects_of_repeated_stimuli_on_prolactin_release_in_vitro_from_normal_and_adenomatous_rat_lactotrophs">Effects of repeated stimuli on prolactin release in vitro from normal and adenomatous rat lactotrophs</a></div><div class="wp-workCard_item"><span>Molecular and Cellular Endocrinology</span><span>, 1986</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">It is now well known that dopamine (DA) plays a major role in the inhibitory control of prolactin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">It is now well known that dopamine (DA) plays a major role in the inhibitory control of prolactin (PRL); however, the mechanisms that are physiologically involved in the stimulation of PRL release are still under investigation. Indeed, although suppression of DA inhibitory tonus, administration of thyrotropin-releasing hormone (TRH) or vasoactive intestinal peptide (VIP) are all known PRL releasers, it is not clear whether they interact during physiological periods of PRL release such as suckling and estrus. No clear indications exist, furthermore, on whether they all act upon a same pituitary pool that may become depleted following repeated exposure to stimuli. Refractoriness to a single or a repeated stimulus has been reported to occur in prolactinoma-bearing or normal humans, respectively, the mechanism of which is still matter for discussion. Our present studies performed by perifusing normal or adenomatous rat lactotrophs attached to Cytodex I microcarrier beads was undertaken to try and answer some of these questions. The experimental period consisted in perifusing the cells for 1 h with Dulbecco&amp;#39;s modified Eagle&amp;#39;s medium (DMEM) containing DA 10(-5) M, then for 2 h with either DMEM, DMEM and TRH 10(-8) M, DMEM and VIP 10(-7) M, then again with DA in DMEM for 1 h, and finally with DMEM, DMEM and TRH, or DMEM and VIP. Three experiments of various combinations were performed. Lower PRL levels were observed under DA, while two periods (first and second) of PRL release followed the suppression of DA infusion with or without the addition of either one of the two peptides.(ABSTRACT TRUNCATED AT 250 WORDS)</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789966"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789966"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789966; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789966]").text(description); $(".js-view-count[data-work-id=104789966]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789966; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789966']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104789966]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789966,"title":"Effects of repeated stimuli on prolactin release in vitro from normal and adenomatous rat lactotrophs","internal_url":"https://www.academia.edu/104789966/Effects_of_repeated_stimuli_on_prolactin_release_in_vitro_from_normal_and_adenomatous_rat_lactotrophs","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. 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Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[{"id":104425310,"title":"","file_type":"txt","scribd_thumbnail_url":"https://attachments.academia-assets.com/104425310/thumbnails/1.jpg","file_name":"84612.txt","download_url":"https://www.academia.edu/attachments/104425310/download_file","bulk_download_file_name":"Involvement_of_MAPK_Signalling_in_Human.txt","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104425310/84612.txt?1689943451=\u0026response-content-disposition=attachment%3B+filename%3DInvolvement_of_MAPK_Signalling_in_Human.txt\u0026Expires=1739890116\u0026Signature=BoUJG8qhO56nVsnsFBbAybaYKFyYs-2AF4I4008QVikgPBb7lQXq-gGyk6cTlK6d8OiNVJvYqwT57AzfZIEG5A6NJNPnpZtlWjpFjLES67sq-V6d0t1CR8dSo~qTvg9fxxpTpC~eNbFBlVi4NSkJNSkyWbh76yVj7hNAkfcmdoeO3JOevZtKNhC78HsjNvC08uhe-hUixRqG9JEZ~P23sqfvnRLE1Kgr6-RcOeGvXy2TqJzLP-m8H~eBVgFogeyfFA4orSro1MkhtahCZFnOuDbZgP8F9js32vToPB9QC7CyBBbxA6I0YGoaP-ftEiMpOdJN-tn2EgfVPrMKlq8hBg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789963"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104789963/Parathyroid_Hormone_Receptor_in_Human_Placental_Syncytiotrophoblast_Brush_Border_and_Basal_Plasma_Membranes_"><img alt="Research paper thumbnail of Parathyroid Hormone Receptor in Human Placental Syncytiotrophoblast Brush Border and Basal Plasma Membranes*" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104789963/Parathyroid_Hormone_Receptor_in_Human_Placental_Syncytiotrophoblast_Brush_Border_and_Basal_Plasma_Membranes_">Parathyroid Hormone Receptor in Human Placental Syncytiotrophoblast Brush Border and Basal Plasma Membranes*</a></div><div class="wp-workCard_item"><span>Endocrinology</span><span>, 1988</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The syncytiotrophoblast of the placenta is the site of exchange of nutrients and minerals between...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The syncytiotrophoblast of the placenta is the site of exchange of nutrients and minerals between the mother and fetus. We have recently demonstrated that PTH influences, in vitro, phosphate transport through the placenta brush border membranes (BBM) and increases cAMP accumulation in placental tissue. To demonstrate the site of binding of PTH in the cytoplasmic membrane, we have purified two polar membranes: the first located on the apical side, the BBM, and the second, on the fetal side, the basal plasma membrane (BPM). BBM were enriched 24-fold in alkaline phosphatase (marker for BBM), and the BPM was enriched 37-fold in binding of [3H] dihydroalprenolol (marker for BPM) compared to homogenate. Both placental membranes contain binding sites (maximum binding = 0.550 +/- 0.032 and 0.298 +/- 0.065 pmol/mg protein for BBM and BPM, respectively) with similar affinities (Kd = 2.05 +/- 0.23 and 1.78 +/- 0.19 nM, respectively) for 125I-[Nle8,Nle18,Tyr34] bovine (b) PTH-(1-34) amide. The three bovine preparations [bPTH-(1-34), its analog [Nle8,Nle18,Try34]bPTH-(1-34) amide, and the antagonist bPTH-(3-34)] were equipotent in binding to both placental membranes. In contrast, human PTH-(1-84) was more effective in displacing the bovine radioligand in BBM. Thyrocalcitonin and insulin, two non-PTH peptides, did not significantly displace the radioligand in BBM and BPM. Adenylate cyclase activity, located exclusively in BPM, was stimulated by PTH. Since the enzyme is absent from BBM, it is probable that the binding of the hormone to this membrane activates another system of messengers.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789963"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789963"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789963; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789963]").text(description); $(".js-view-count[data-work-id=104789963]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789963; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789963']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104789963]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789963,"title":"Parathyroid Hormone Receptor in Human Placental Syncytiotrophoblast Brush Border and Basal Plasma Membranes*","internal_url":"https://www.academia.edu/104789963/Parathyroid_Hormone_Receptor_in_Human_Placental_Syncytiotrophoblast_Brush_Border_and_Basal_Plasma_Membranes_","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789961"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104789961/Role_of_Calcium_and_Sodium_Ions_in_the_Inhibitory_Control_of_Baseline_and_Stimulated_Prolactin_Release_"><img alt="Research paper thumbnail of Role of Calcium and Sodium Ions in the Inhibitory Control of Baseline and Stimulated Prolactin Release*" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104789961/Role_of_Calcium_and_Sodium_Ions_in_the_Inhibitory_Control_of_Baseline_and_Stimulated_Prolactin_Release_">Role of Calcium and Sodium Ions in the Inhibitory Control of Baseline and Stimulated Prolactin Release*</a></div><div class="wp-workCard_item"><span>Endocrinology</span><span>, 1986</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The mechanism of dopamine (DA) inhibition of pituitary PRL release is still unclear. To study it,...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The mechanism of dopamine (DA) inhibition of pituitary PRL release is still unclear. To study it, we utilized enzymatically dispersed anterior pituitary cells obtained from adult female Sprague-Dawley rats. The cells were incubated in media with or without Na+ and in the presence or the absence of various drugs for 30 min for evaluating the secretion of PRL under baseline and experimental conditions. In some experiments, 45Ca2+ (1 microCi/ml) was added after 30 min of incubation and the latter prolonged for an additional minute to determine Ca2+ uptake. DA inhibited baseline PRL release and 45Ca2+ uptake in a dose-dependent manner only in the presence of Na+ and was totally inactive in its absence. The inhibitory effects of Nifedipine and Nicardipine, two Ca2+ channel antagonists, on PRL release were also found to be Na+ dependent. BAY K 8644, a Ca2+ channel agonist, stimulated PRL release and Ca2+ uptake in a dose-dependent manner, and these effects were enhanced by Na+-free media. DA antagonized the stimulatory actions of BAY K 8644 on PRL release in a similar dose-dependent manner both in the presence and the absence of Na+. However, on stimulated 45Ca2+ uptake DA was less effective in the absence of Na+. The stimulatory action of TRH on PRL release was enhanced by the absence of Na+. DA antagonized the effect of TRH in a dose-dependent manner both in the presence and in the absence of Na+ but appeared more effective in the absence of the ion. The PRL-releasing effects of phorbol ester and of the Ca2+ ionophore A23187 were antagonized by DA in a Na+- independent manner. These results suggest the existence of two mechanisms of DA inhibitory action: one exerted on baseline PRL release which is Na+ dependent, receptor linked, and probably implicates potential operated Ca2+ channels; the other is exerted on stimulated PRL release, is Na+ independent, and appears to be a postreceptorial intracellular event probably involving protein kinase C and/or cytosolic Ca2+ levels.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789961"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789961"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789961; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789961]").text(description); $(".js-view-count[data-work-id=104789961]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789961; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789961']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104789961]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789961,"title":"Role of Calcium and Sodium Ions in the Inhibitory Control of Baseline and Stimulated Prolactin Release*","internal_url":"https://www.academia.edu/104789961/Role_of_Calcium_and_Sodium_Ions_in_the_Inhibitory_Control_of_Baseline_and_Stimulated_Prolactin_Release_","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789960"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104789960/Site_specific_effects_of_sympathectomy_on_the_adrenergic_control_of_lipolysis_in_hamster_fat_cells"><img alt="Research paper thumbnail of Site-specific effects of sympathectomy on the adrenergic control of lipolysis in hamster fat cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104789960/Site_specific_effects_of_sympathectomy_on_the_adrenergic_control_of_lipolysis_in_hamster_fat_cells">Site-specific effects of sympathectomy on the adrenergic control of lipolysis in hamster fat cells</a></div><div class="wp-workCard_item"><span>Canadian Journal of Physiology and Pharmacology</span><span>, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Regional variations in the response of adipose tissue to lipolytic stimuli have been suggested to...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Regional variations in the response of adipose tissue to lipolytic stimuli have been suggested to be involved in the development of visceral adiposity-related morbidity and mortality. Moreover, studies in humans and in laboratory rodents such as hamsters have shown that the response of adipocytes to catecholamines depends on their anatomical origin. The aim of the present study was to investigate the relative involvement of the adrenal medulla and of the sympathetic nervous system on regional differences in the adrenergic control of lipolysis in isolated adipocytes from inguinal and epididymal adipose tissues. For this purpose, we carried out adrenal demedullation or chemical sympathectomy in hamsters. The results confirmed that epididymal adipocytes were significantly more responsive to a β-adrenergic stimulation than inguinal adipocytes (p ≤ 0.05). This site specificity could originate at a step distal to receptors since tissues exhibited a similar number of binding sites for [125...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789960"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789960"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789960; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789960]").text(description); $(".js-view-count[data-work-id=104789960]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789960; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789960']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104789960]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789960,"title":"Site-specific effects of sympathectomy on the adrenergic control of lipolysis in hamster fat cells","internal_url":"https://www.academia.edu/104789960/Site_specific_effects_of_sympathectomy_on_the_adrenergic_control_of_lipolysis_in_hamster_fat_cells","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789959"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104789959/Selective_uptake_of_cholesteryl_esters_from_various_classes_of_lipoproteins_by_HepG2_cells"><img alt="Research paper thumbnail of Selective uptake of cholesteryl esters from various classes of lipoproteins by HepG2 cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104789959/Selective_uptake_of_cholesteryl_esters_from_various_classes_of_lipoproteins_by_HepG2_cells">Selective uptake of cholesteryl esters from various classes of lipoproteins by HepG2 cells</a></div><div class="wp-workCard_item"><span>Biochemistry and Cell Biology</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Selective uptake of cholesteryl esters (CE) from lipoproteins by cells has been extensively studi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Selective uptake of cholesteryl esters (CE) from lipoproteins by cells has been extensively studied with high density lipoproteins (HDL). It is only recently that such a mechanism has been attributed to intermediate and low density lipoproteins (IDL and LDL). Here, we compare the association of proteins and CE from very low density lipoproteins (VLDL), IDL, LDL and HDL3 to HepG2 cells. These lipoproteins were either labelled in proteins with 125I or in CE with 3H-cholesteryl oleate. We show that, at any lipoprotein concentration, protein association to the cells is significantly smaller for IDL, LDL, and HDL3 than CE association, but not for VLDL. At a concentration of 20 µg lipoprotein/mL, these associations reveal CE-selective uptake in the order of 2-, 4-, and 11-fold for IDL, LDL, and HDL3, respectively. These studies reveal that LDL and HDL3 are good selective donors of CE to HepG2 cells, while IDL is a poor donor and VLDL is not a donor. A significant inverse correlation (r2 = 0.973) was found between the total lipid/protein ratios of the four classes of lipoproteins and the extent of CE-selective uptake by HepG2 cells. The fate of 3H-CE of the two best CE donors (LDL and HDL3) was followed in HepG2 cells after 3 h of incubation. Cells were shown to hydrolyze approximately 25% of the 3H-CE of both lipoproteins. However, when the cells were treated with 100 µM of chloroquine, a lysosomotropic agent, 85 and 40% of 3H-CE hydrolysis was lost for LDL and HDL3, respectively. The fate of LDL and HDL3-CE in HepG2 cells deficient in LDL-receptor was found to be the same, indicating that the portion of CE hydrolysis sensitive to chloroquine is not significantly linked to LDL-receptor activity. Thus, in HepG2 cells, the magnitude of CE-selective uptake is inversely correlated with the total lipid/protein ratios of the lipoproteins and CE-selective uptake from the two best CE donors (LDL and HDL3) appears to follow different pathways.Key words: lipoprotein, receptor, HepG2 cell, selective uptake, lipid, cholesterol, binding.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789959"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789959"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789959; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789959]").text(description); $(".js-view-count[data-work-id=104789959]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789959; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789959']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104789959]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789959,"title":"Selective uptake of cholesteryl esters from various classes of lipoproteins by HepG2 cells","internal_url":"https://www.academia.edu/104789959/Selective_uptake_of_cholesteryl_esters_from_various_classes_of_lipoproteins_by_HepG2_cells","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104789939"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104789939/Influence_of_insulin_on_phosphate_uptake_by_brush_border_membranes_from_human_placenta"><img alt="Research paper thumbnail of Influence of insulin on phosphate uptake by brush border membranes from human placenta" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104789939/Influence_of_insulin_on_phosphate_uptake_by_brush_border_membranes_from_human_placenta">Influence of insulin on phosphate uptake by brush border membranes from human placenta</a></div><div class="wp-workCard_item"><span>Molecular and Cellular Endocrinology</span><span>, 1989</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Regulation of phosphate transport by insulin was investigated in brush border membranes from huma...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Regulation of phosphate transport by insulin was investigated in brush border membranes from human placenta at term. At 22 degrees C, a 45 min incubation of the total tissue with 10(-6) M insulin significantly decreased both the initial rate and the peak of sodium-dependent phosphate uptake by the corresponding brush border membranes. In contrast, Na+ transport was not influenced by the hormone. Increasing the insulin concentration from 0 to 10(-5) M resulted in a dose-dependent inhibition of phosphate uptake with half-maximal effect at 1.1 x 10(-9) M. The hormone decreased PO4 transport by decreasing the affinity of the carrier for the substrate (Km = 0.180 +/- 0.010 mM and 0.215 +/- 0.015 mM in absence and presence of 10(-6) M insulin respectively, P less than 0.05). The inhibitory effect of insulin required the presence of Mn2+ whereas neither Mn2+ nor insulin alone had any influence on PO4 uptake. It is therefore assumed that receptor phosphorylation, which needs the presence of Mn2+, is an intermediate step of insulin action on PO4 uptake by the subsequently isolated brush border membranes. In contrast, insulin had no effect on PO4 uptake when the membranes were directly incubated with the hormone prior to the transport measurement, suggesting that an intracellular messenger is needed for the inhibitory effect. This messenger is not cAMP since insulin at 10(-6) M concentration has no effect on cAMP content of the total placental tissue.(ABSTRACT TRUNCATED AT 250 WORDS)</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104789939"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104789939"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104789939; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104789939]").text(description); $(".js-view-count[data-work-id=104789939]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104789939; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104789939']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104789939]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104789939,"title":"Influence of insulin on phosphate uptake by brush border membranes from human placenta","internal_url":"https://www.academia.edu/104789939/Influence_of_insulin_on_phosphate_uptake_by_brush_border_membranes_from_human_placenta","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="100697474"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/100697474/Effect_of_an_enriched_cholesterol_diet_during_gestation_on_fatty_acid_synthase_HMG_CoA_reductase_and_SREBP_1_2_expressions_in_rabbits"><img alt="Research paper thumbnail of Effect of an enriched cholesterol diet during gestation on fatty acid synthase, HMG-CoA reductase and SREBP-1/2 expressions in rabbits" class="work-thumbnail" src="https://attachments.academia-assets.com/101446744/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/100697474/Effect_of_an_enriched_cholesterol_diet_during_gestation_on_fatty_acid_synthase_HMG_CoA_reductase_and_SREBP_1_2_expressions_in_rabbits">Effect of an enriched cholesterol diet during gestation on fatty acid synthase, HMG-CoA reductase and SREBP-1/2 expressions in rabbits</a></div><div class="wp-workCard_item"><span>Life Sciences</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Pregnancy is associated with hyperlipidemia and hypercholesterolemia in humans. These changes tak...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Pregnancy is associated with hyperlipidemia and hypercholesterolemia in humans. These changes take place to support fetal growth and development, and modifications of these maternal concentrations may influence lipids and cholesterol synthesis in the dam, fetus and placenta. Administration of a 0.2% enriched cholesterol diet (ECD) during rabbit gestation significantly increased cholesterol and triglyceride (TG) levels in maternal livers and decreased fetal weight by 15%. Here we used Western blot analysis to examine the impact of gestation and 0.2% ECD on the expression levels of fatty acid synthase (FAS), HMGR and SREBP-1/2, which are involved in either lipid or cholesterol synthesis. We confirmed that gestation modifies the hepatic and circulating lipid profile in the mother. Our data also suggest that the maternal liver mainly supports lipogenesis, while the placenta plays a key role in cholesterol synthesis. Thus, our data demonstrate a decrease in HMGR protein levels in dam livers by feeding an ECD. In the placenta, SREBPs are highly expressed, and the ECD supplementation increased nuclear SREBP-1/2 protein levels. In addition, our results show a decrease in FAS protein levels in non-pregnant liver and in the liver of offspring from ECD-treated animals. Finally, our data suggest that the placenta does not modify its own cholesterol synthesis in response to an increase in circulating cholesterol. However, the dam liver compensates for this increase by essentially decreasing the level of HMGR expression. Because HMGR and FAS expressions do not correlate with the circulating lipid profile, it would be interesting to find which genes are then targeted by SREBP-1/2 during gestation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="34fe8ceefc5c4b3a33116c583ed8db00" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":101446744,"asset_id":100697474,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/101446744/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="100697474"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="100697474"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 100697474; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=100697474]").text(description); $(".js-view-count[data-work-id=100697474]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 100697474; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='100697474']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "34fe8ceefc5c4b3a33116c583ed8db00" } } $('.js-work-strip[data-work-id=100697474]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":100697474,"title":"Effect of an enriched cholesterol diet during gestation on fatty acid synthase, HMG-CoA reductase and SREBP-1/2 expressions in rabbits","internal_url":"https://www.academia.edu/100697474/Effect_of_an_enriched_cholesterol_diet_during_gestation_on_fatty_acid_synthase_HMG_CoA_reductase_and_SREBP_1_2_expressions_in_rabbits","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[{"id":101446744,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/101446744/thumbnails/1.jpg","file_name":"j.lfs.2007.07.01620230424-1-8ci9ta.pdf","download_url":"https://www.academia.edu/attachments/101446744/download_file","bulk_download_file_name":"Effect_of_an_enriched_cholesterol_diet_d.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/101446744/j.lfs.2007.07.01620230424-1-8ci9ta-libre.pdf?1682355616=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_an_enriched_cholesterol_diet_d.pdf\u0026Expires=1739921520\u0026Signature=TqhWqSHGO6IICUWDJRhBMC3HXbpstBUOXwlTBdOy-tDbH4VbHi5sn3N83kOPpby0a1Rd2aS7Y6jOxMr2sL7NBtS-YU8PNPi-D507ZRtDo~QUP2AQ32ALCg4AiRJ~7TqOTuHi6e2EMdw4tllr9XeuED1cjAMI-0Ycti6ufzJFCLKIqwy~XD6vzNy1zp58Bh7IaB6FZpMnxP1UvyrdXVdqeGL-VIDa07-L2qfUyXDbLqP-D4pZ9eO-aGT005ymhtWNBCL8LS7WLzysdLbgg7SjWebJqKLnyXd6vP0~k3l4-2CyU6G~pm2tcUDgO-fF5CvJOEKOvy-v~dSV48~YWewMyA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="88195360"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/88195360/Impact_of_maternal_and_neonatal_iron_status_on_placental_transferrin_receptor_expression_in_pregnant_adolescents"><img alt="Research paper thumbnail of Impact of maternal and neonatal iron status on placental transferrin receptor expression in pregnant adolescents" class="work-thumbnail" src="https://attachments.academia-assets.com/92215243/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/88195360/Impact_of_maternal_and_neonatal_iron_status_on_placental_transferrin_receptor_expression_in_pregnant_adolescents">Impact of maternal and neonatal iron status on placental transferrin receptor expression in pregnant adolescents</a></div><div class="wp-workCard_item"><span>Placenta</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective: To elucidate the role of maternal and neonatal iron status on placental transferrin re...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective: To elucidate the role of maternal and neonatal iron status on placental transferrin receptor (TfR) expression. Study design and outcomes: Ninety-two healthy pregnant adolescents (ages 14e18 years) were followed across pregnancy. Maternal iron status (hemoglobin, hematocrit, serum ferritin, TfR, and total body iron) was assessed in mid-gestation (21e25 wks) and at delivery in the mother and neonate. Placental TfR protein expression was assessed by western blot in placental tissue collected at delivery. Results: Placental TfR expression was inversely associated with maternal iron status at mid-gestation (hemoglobin p ¼ 0.046, R 2 ¼ 0.1 and hematocrit p ¼ 0.005, R 2 ¼ 0.24) and at delivery (serum ferritin p ¼ 0.02, R 2 ¼ 0.08 and total body iron p ¼ 0.02, R 2 ¼ 0.07). Mothers with depleted body iron stores had significantly greater placental expression of TfR than mothers with body iron stores greater than zero (p ¼ 0.003). Neonatal iron stores were also inversely associated with the expression of placental TfR (p ¼ 0.04, R 2 ¼ 0.06). Neonates with serum ferritin values 34 mg/L had significantly greater protein expression of placental TfR compared to neonates with cord serum ferritin values >34 mg/L (p ¼ 0.01). Conclusions: Expression of placental TfR is associated with both maternal and neonatal iron demands. Increased expression of placental TfR may be an important compensatory mechanism in response to iron deficiency in otherwise healthy pregnant women.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5e0b0556bce733414037842fe0504efb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":92215243,"asset_id":88195360,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/92215243/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="88195360"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="88195360"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 88195360; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=88195360]").text(description); $(".js-view-count[data-work-id=88195360]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 88195360; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='88195360']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5e0b0556bce733414037842fe0504efb" } } $('.js-work-strip[data-work-id=88195360]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":88195360,"title":"Impact of maternal and neonatal iron status on placental transferrin receptor expression in pregnant adolescents","internal_url":"https://www.academia.edu/88195360/Impact_of_maternal_and_neonatal_iron_status_on_placental_transferrin_receptor_expression_in_pregnant_adolescents","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[{"id":92215243,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/92215243/thumbnails/1.jpg","file_name":"j.placenta.2010.08.00920221010-1-7hah2b.pdf","download_url":"https://www.academia.edu/attachments/92215243/download_file","bulk_download_file_name":"Impact_of_maternal_and_neonatal_iron_sta.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/92215243/j.placenta.2010.08.00920221010-1-7hah2b-libre.pdf?1665365246=\u0026response-content-disposition=attachment%3B+filename%3DImpact_of_maternal_and_neonatal_iron_sta.pdf\u0026Expires=1739921520\u0026Signature=YeZeTXAzXsnYh-hkg7Fj9yyt3uMKtzW1eHgqU3u31s6QR6s1EG7~Q1EXTG23~IZr1EwqabCgorPHqBTAMhPgmIuNMHR3i8Mm8m1So3J4Sa4sYpy3EIg3OUx0ZLHb6r5xjaE9WzJbd-s9SRHLyCk-mmB343CHE1fWFU9WVT9WqENbuWCpV6f~9hKQgNNgLeAYTJyypAK4jpZMbWzr7M-UoDKDRjXcvvfgWKidYn4UOPEdlaBLh~Kyyb6CVY37GSrrIidZDl-UivH8nj~Is1XBn9OTWvbj61KZlwtwwC2sUiReEQCKCA2vmg3KRrSMqTgxY5oSKarN4YGIwpreHNKXBQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="56052644"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/56052644/Calbindin_D9k_CaBP9k_localization_and_levels_of_expression_in_trophoblast_cells_from_human_term_placenta"><img alt="Research paper thumbnail of Calbindin-D9k (CaBP9k) localization and levels of expression in trophoblast cells from human term placenta" class="work-thumbnail" src="https://attachments.academia-assets.com/71628434/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/56052644/Calbindin_D9k_CaBP9k_localization_and_levels_of_expression_in_trophoblast_cells_from_human_term_placenta">Calbindin-D9k (CaBP9k) localization and levels of expression in trophoblast cells from human term placenta</a></div><div class="wp-workCard_item"><span>Cell and Tissue Research</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">During pregnancy, the calcium (Ca 2+) transport machinery of the placenta is solely responsible f...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">During pregnancy, the calcium (Ca 2+) transport machinery of the placenta is solely responsible for the nutrient supply to the developing fetus, where active Ca 2+ transport occurs from the mother to the fetus. As part of a larger study to determine the role of Ca 2+ in placental transport in vivo, we questioned whether calbindin-D9k (CaBP9k), which is mainly expressed in duodenum, uterus, and placenta of several mammals, is present in cytotrophoblast cells and syncytiotrophoblasts of human term placenta. We were interested in this protein because of its potential importance in serving as an indicator of Ca 2+ availability and utilization in the placenta. Here, we demonstrated that CaBP9k transcript is present in both cell types, with a lower expression in cytotrophoblast cells as compared to syncytiotrophoblasts. Moreover, we showed by immunochemistry that CaBP9k protein was present in cytotrophoblast and syncytiotrophoblast placental tissue sections as well as in cultured cells. The occurrence of CaBP9k protein in trophoblast cells was further confirmed by Western blot analysis. Thus, these results indicate for the first time that CaBP9k is unequivocally expressed by trophoblast cells from human term placenta.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ef2ab56859d2d4aba8a0215e46f3c07e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71628434,"asset_id":56052644,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71628434/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="56052644"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="56052644"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 56052644; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=56052644]").text(description); $(".js-view-count[data-work-id=56052644]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 56052644; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='56052644']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ef2ab56859d2d4aba8a0215e46f3c07e" } } $('.js-work-strip[data-work-id=56052644]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":56052644,"title":"Calbindin-D9k (CaBP9k) localization and levels of expression in trophoblast cells from human term placenta","internal_url":"https://www.academia.edu/56052644/Calbindin_D9k_CaBP9k_localization_and_levels_of_expression_in_trophoblast_cells_from_human_term_placenta","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. Lafond","url":"https://independent.academia.edu/JLafond"},"attachments":[{"id":71628434,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71628434/thumbnails/1.jpg","file_name":"s00441-003-0811-420211006-10629-1ymdq1.pdf","download_url":"https://www.academia.edu/attachments/71628434/download_file","bulk_download_file_name":"Calbindin_D9k_CaBP9k_localization_and_le.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71628434/s00441-003-0811-420211006-10629-1ymdq1-libre.pdf?1635228957=\u0026response-content-disposition=attachment%3B+filename%3DCalbindin_D9k_CaBP9k_localization_and_le.pdf\u0026Expires=1739921520\u0026Signature=YrLXyiC-wEpnSoF6U85lNkrF0-DwElZS-xvR~xeE7PPIeiGvNDEUD86NPW2XoGhemWoPf1w7hMeT1-KfZ-k7iArWrQw9R-yNKAHPJBlMk4-zH75H98HIb3FDwDQZbJaec578oJmhvCSvt-V9gNh9w-tGZZqdiMu-SjfcM02161iYEHgUNFyjKzSbVpty4XaSDtbocc7MTAAS8GnNLbk0zp9PhEJfj68DC~NeuawyxmTqnFV1aI9TkBWWPYz4emNHAhPoAgwANhm2CiuQhStj58LoqL9avjYMesD8lcKs4t8ZpinpNbaXsq7Fr~-UCIRbMDDotXdQrtjPgRk1L0vOPQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="11744394"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/11744394/Calcitonin_receptor_in_human_placental_syncytiotrophoblast_brush_border_and_basal_plasma_membranes"><img alt="Research paper thumbnail of Calcitonin receptor in human placental syncytiotrophoblast brush border and basal plasma membranes" class="work-thumbnail" src="https://attachments.academia-assets.com/46549189/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/11744394/Calcitonin_receptor_in_human_placental_syncytiotrophoblast_brush_border_and_basal_plasma_membranes">Calcitonin receptor in human placental syncytiotrophoblast brush border and basal plasma membranes</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/DanielLajeunesse">Daniel Lajeunesse</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/JLafond">J. Lafond</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We wish to make amendments in three places:</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7a8ab6083de0f7702d845dc80efd3d1a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46549189,"asset_id":11744394,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46549189/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="11744394"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="11744394"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 11744394; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=11744394]").text(description); $(".js-view-count[data-work-id=11744394]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 11744394; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='11744394']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="22611321"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/22611321/Environmental_exposure_to_cadmium_and_human_birthweight"><img alt="Research paper thumbnail of Environmental exposure to cadmium and human birthweight" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/22611321/Environmental_exposure_to_cadmium_and_human_birthweight">Environmental exposure to cadmium and human birthweight</a></div><div class="wp-workCard_item"><span>Toxicology</span><span>, 1993</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Fetal toxicity of cadmium (Cd) is well documented in rodents. However, little information is avai...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Fetal toxicity of cadmium (Cd) is well documented in rodents. However, little information is available regarding the human fetus. To investigate the effect of low levels of Cd on the human placenta and the consequences on birthweight, we conducted a study of 102 mothers and their newborns in an obstetrical care unit. Placental and hair samples were collected at delivery to determine Cd concentrations. The main finding of this study was the relationship between a decrease in birthweight and an increase of newborn hair Cd which varied in the presence of placental calcification. In cases of parenchymal calcifications, placental Cd levels were higher (Wilcoxon test, P &amp;lt; 0.05) and newborn hair Cd levels were lower (Wilcoxon test, P &amp;lt; 0.01) than in the absence of calcification. These relationships remained significant even after taking into account smoking habits and gestational age. In the presence of calcification, an increase in the level of Cd in newborn hair was related to a decrease in birthweight which was independent of placental Cd concentration (rpartial = -0.49, P &amp;lt; 0.01). In the absence of calcification, a decrease in birthweight was observed for the upper values of newborn hair Cd (r = -0.44, P &amp;lt; 0.05 when Cd &amp;gt; or = 0.3 ppm). The difference in birthweight between infants in the first and last quartiles of newborn hair Cd was 472 g in cases of calcifications and 122 g in the absence of calcification. Other placental parameters were not significantly related to placental Cd concentration.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="22611321"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="22611321"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22611321; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22611321]").text(description); $(".js-view-count[data-work-id=22611321]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22611321; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='22611321']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=22611321]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":22611321,"title":"Environmental exposure to cadmium and human birthweight","internal_url":"https://www.academia.edu/22611321/Environmental_exposure_to_cadmium_and_human_birthweight","owner_id":34773787,"coauthors_can_edit":true,"owner":{"id":34773787,"first_name":"J.","middle_initials":null,"last_name":"Lafond","page_name":"JLafond","domain_name":"independent","created_at":"2015-09-11T06:43:57.517-07:00","display_name":"J. 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