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tablet-hidden"><a href="#" class="trigger-overlay search-icon" data-area="search" data-container="box-container" aria-label="Ricerca"> <i class="fa fa-search3"></i><span class="desktop-hidden"><span>Ricerca</span></span><i class="fa fa-angle-down fa-dropdown desktop-hidden"></i> </a></li></ul></div></div></div></div></div></div></div></header></div><div class="main-wrapper"><div class="main-container"><div class="page-wrapper"><div class="sections-container"><div id="page-header"><div class="remove-menu-padding remove-menu-padding-mobile header-wrapper header-uncode-block"><div data-parent="true" class="vc_row style-color-329317-bg row-container" id="row-unique-0"><div class="row single-top-padding single-bottom-padding triple-h-padding full-width row-parent row-header" data-height-ratio="70"><div class="wpb_row row-inner"><div class="wpb_column pos-middle pos-center align_left column_parent col-lg-12 single-internal-gutter"><div class="uncol style-light" ><div class="uncoltable"><div class="uncell no-block-padding" ><div class="uncont" ><div class="vc_row row-internal row-container"><div class="row row-child"><div class="wpb_row row-inner"><div class="wpb_column pos-middle pos-center align_left column_child col-lg-12 single-internal-gutter"><div class="uncol style-light" ><div class="uncoltable"><div class="uncell no-block-padding" ><div class="uncont" ><div class="empty-space empty-half" ><span class="empty-space-inner"></span></div><div class="vc_custom_heading_wrap "><div class="heading-text el-text bottom-t-top animate_when_almost_visible" data-delay="400"><h5 class="h5 fontspace-210350" ><span>PRODOTTI</span></h5></div><div class="clear"></div></div><div class="vc_custom_heading_wrap "><div class="heading-text el-text" ><h1 class="font-weight-400" ><span>AVITI™️ NGS System</span></h1></div><div class="clear"></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div><script id="script-row-unique-0" data-row="script-row-unique-0" type="text/javascript" class="vc_controls">UNCODE.initRow(document.getElementById("row-unique-0"));</script></div></div></div></div></div><article id="post-104208" class="page-body style-color-xsdn-bg post-104208 post type-post status-publish format-standard hentry category-prodotti"><div class="post-wrapper"><div class="post-body"><div class="post-content un-no-sidebar-layout"><div data-parent="true" class="vc_row row-container onepage-section" data-label="neonatale" data-name="neonatale" id="row-unique-1"><div class="row double-top-padding single-bottom-padding triple-h-padding full-width row-parent"><div class="wpb_row row-inner"><div class="wpb_column pos-middle pos-left align_left column_parent col-lg-12 single-internal-gutter"><div class="uncol style-light" ><div class="uncoltable"><div class="uncell no-block-padding" ><div class="uncont" ><div class="vc_row row-internal row-container"><div class="row row-child"><div class="wpb_row row-inner"><div class="wpb_column pos-top pos-left align_left column_child col-lg-12 single-internal-gutter"><div class="uncol style-light" ><div class="uncoltable"><div class="uncell no-block-padding" ><div class="uncont" ><div class="vc_custom_heading_wrap "><div class="heading-text el-text left-t-right animate_when_almost_visible" data-delay="300"><h2 class="h2 text-accent-color" ><span>Element AVITI System</span></h2></div><div class="clear"></div></div><div class="divider-wrapper left-t-right animate_when_almost_visible" data-delay="400" ><hr class="border-color-648163-color separator-no-padding" /></div></div></div></div></div></div></div></div></div></div></div></div></div></div><script id="script-row-unique-1" data-row="script-row-unique-1" type="text/javascript" class="vc_controls">UNCODE.initRow(document.getElementById("row-unique-1"));</script></div></div></div><div data-parent="true" class="vc_row row-container onepage-section" data-label="neonatale" data-name="neonatale" id="row-unique-2"><div class="row no-top-padding single-bottom-padding triple-h-padding full-width row-parent"><div class="wpb_row row-inner"><div class="wpb_column pos-middle pos-left align_left column_parent col-lg-12 single-internal-gutter"><div class="uncol style-light" ><div class="uncoltable"><div class="uncell no-block-padding" ><div class="uncont" ><div class="vc_row row-internal row-container"><div class="row row-child"><div class="wpb_row row-inner"><div class="wpb_column pos-top pos-left align_left column_child col-lg-6 half-internal-gutter"><div class="uncol style-light animate_when_almost_visible bottom-t-top" data-delay="400"><div class="uncoltable"><div class="uncell no-block-padding" ><div class="uncont" ><div class="vc_custom_heading_wrap "><div class="heading-text el-text" ><h3 class="fontheight-162334 font-weight-600 text-accent-color" ><span>La rivoluzione nel panorama dei sistemi NGS da benchtop.</span></h3></div><div class="clear"></div></div><div class="uncode_text_column" ><p><strong>Dal Next Generation Sequencing by Synthesis (SBS) alla Avidity Base Chemistry (ABC).</strong><br /> La Next-generation sequencing (NGS) ha trasformato la nostra comprensione della biologia, dalla salute umana, a quella degli animali, delle piante fino ad arrivare al mondo dei microbi. I progressi passati hanno alimentato una brillante era della genomica, ma gli avanzamenti della tecnologia di base sono da allora fermi. In questo panorama, la Avidity Base Chemistry (ABC) è una tecnologia di sequenziamento innovativa che sfrutta la potenza delle avidine per superare i modelli consolidati migliorandoli in termini di costi, qualità e flessibilità.</p></div><div class="uncode_text_column" ><p><strong>AVITI™</strong>, l’innovativo sistema di sequenziamento messo a punto da Element Biosciences, basata sulla chimica di sequenziamento ABC, utilizza la Rolling Circle Amplification (RCA): il frammento da sequenziare, inizialmente lineare, si circolarizza sulla Flow Cell. A partire da questa, si creano migliaia di copie ognuna delle quali viene generata sempre a partire dal frammento originario e non come copia delle copie (copie clonali). La grande innovazione risiede nel fatto che se un errore viene introdotto dalla PCR questo è puramente randomico e non si propaga su tutte le copie. Ciò aumenta drasticamente la qualità del dato prodotta.</p></div><div class="uncode_text_column" ><p><strong>Q-score di 40 o superiore (Q 40 +)</strong><br /> AVITI™ fornisce un’elevata accuratezza con un Q-score di 40 o superiore, che corrisponde a un tasso di errore inferiore a 1 su 10.000 basi. Questo garantisce sequenziamenti di alta qualità e precisione, rendendo il sistema ideale per applicazioni che richiedono dati altamente affidabili.</p></div></div></div></div></div></div><div class="wpb_column pos-top pos-center align_left column_child col-lg-6 single-internal-gutter"><div class="uncol style-light animate_when_almost_visible bottom-t-top" data-delay="400"><div class="uncoltable"><div class="uncell no-block-padding" ><div class="uncont" ><div class="uncode-single-media text-left"><div class="single-wrapper" style="max-width: 100%;"><div class="tmb tmb-light tmb-media-first tmb-media-last tmb-content-overlay tmb-no-bg"><div class="t-inside"><div class="t-entry-visual"><div class="t-entry-visual-tc"><div class="uncode-single-media-wrapper"><img decoding="async" class="srcset-async srcset-auto wp-image-104296" src="https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-Componenti-Strumento.jpg" width="2496" height="1400" alt="" data-no-bp="" data-bp="720,1032" data-uniqueid="104296-197414" data-guid="https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-Componenti-Strumento.jpg" data-path="2024/06/Element-AVITI-Componenti-Strumento.jpg" data-width="2496" data-height="1400" data-singlew="6" data-singleh="" data-crop="" loading="lazy" data-srcset="https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-Componenti-Strumento.jpg 2496w, https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-Componenti-Strumento-300x168.jpg 300w, https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-Componenti-Strumento-1024x574.jpg 1024w, https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-Componenti-Strumento-768x431.jpg 768w, https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-Componenti-Strumento-1536x862.jpg 1536w, https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-Componenti-Strumento-2048x1149.jpg 2048w, https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-Componenti-Strumento-350x196.jpg 350w, https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-Componenti-Strumento-uai-720x404.jpg 720w, https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-Componenti-Strumento-uai-1032x579.jpg 1032w" srcset="data:image/svg+xml;base64,PHN2ZyB3aWR0aD0iMjQ5NiIgaGVpZ2h0PSIxNDAwIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxwYXRoIGQ9Ik0wIDBoMXYxSDB6IiBmaWxsPSJub25lIiBmaWxsLXJ1bGU9ImV2ZW5vZGQiLz48L3N2Zz4="></div></div></div></div></div></div></div><div class="uncode_text_column" ><p><strong>A</strong> Touchscreen user interface for run setup<br /> <strong>B</strong> Fluidics punp bay side A<br /> <strong>C</strong> Fluidics pump bay side B<br /> <strong>D</strong> Flow cell nest bay<br /> <strong>E</strong> Ventilated housing<br /> <strong>F</strong> Two waste bottles, one per flow cell<br /> <strong>G</strong> Sequencing reagent cartridge side A<br /> <strong>H</strong> Sequencing reagent cartridge side B</p></div></div></div></div></div></div></div></div></div><div class="vc_row row-internal row-container"><div class="row row-child"><div class="wpb_row row-inner"><div class="wpb_column pos-top pos-left align_left column_child col-lg-6 half-internal-gutter"><div class="uncol style-light animate_when_almost_visible bottom-t-top" data-delay="400"><div class="uncoltable"><div class="uncell no-block-padding" ><div class="uncont" ><div class="uncode-single-media bordo-immagini text-left"><div class="single-wrapper" style="max-width: 100%;"><div class="tmb tmb-light tmb-media-first tmb-media-last tmb-content-overlay tmb-no-bg"><div class="t-inside"><div class="t-entry-visual"><div class="t-entry-visual-tc"><div class="uncode-single-media-wrapper"><img decoding="async" class="srcset-async srcset-auto wp-image-104299" src="https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-RCA-Sequencing-System-LionDx-scaled.jpg" width="2560" height="1542" alt="" data-no-bp="" data-bp="720,1032" data-uniqueid="104299-757284" data-guid="https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-RCA-Sequencing-System-LionDx-scaled.jpg" data-path="2024/06/Element-AVITI-RCA-Sequencing-System-LionDx-scaled.jpg" data-width="2560" data-height="1542" data-singlew="6" data-singleh="" data-crop="" loading="lazy" data-srcset="https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-RCA-Sequencing-System-LionDx-scaled.jpg 2560w, https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-RCA-Sequencing-System-LionDx-300x181.jpg 300w, https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-RCA-Sequencing-System-LionDx-1024x617.jpg 1024w, https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-RCA-Sequencing-System-LionDx-768x463.jpg 768w, https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-RCA-Sequencing-System-LionDx-1536x925.jpg 1536w, https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-RCA-Sequencing-System-LionDx-2048x1234.jpg 2048w, https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-RCA-Sequencing-System-LionDx-350x211.jpg 350w, https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-RCA-Sequencing-System-LionDx-scaled-uai-720x434.jpg 720w, https://liondx.com/wp-content/uploads/2024/06/Element-AVITI-RCA-Sequencing-System-LionDx-scaled-uai-1032x622.jpg 1032w" srcset="data:image/svg+xml;base64,PHN2ZyB3aWR0aD0iMjU2MCIgaGVpZ2h0PSIxNTQyIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxwYXRoIGQ9Ik0wIDBoMXYxSDB6IiBmaWxsPSJub25lIiBmaWxsLXJ1bGU9ImV2ZW5vZGQiLz48L3N2Zz4="></div></div></div></div></div></div></div><div class="empty-space empty-single" ><span class="empty-space-inner"></span></div><div class="uncode-single-media bordo-immagini text-left"><div class="single-wrapper" style="max-width: 100%;"><div class="tmb tmb-light tmb-media-first tmb-media-last tmb-content-overlay tmb-no-bg"><div class="t-inside"><div class="t-entry-visual"><div class="t-entry-visual-tc"><div class="uncode-single-media-wrapper"><img decoding="async" class="srcset-async srcset-auto wp-image-104298" src="https://liondx.com/wp-content/uploads/2024/06/ELEMENT-ABC-NGS-Italia-LionDx-scaled.jpg" width="2560" height="1270" alt="" data-no-bp="" data-bp="720,1032" data-uniqueid="104298-679030" data-guid="https://liondx.com/wp-content/uploads/2024/06/ELEMENT-ABC-NGS-Italia-LionDx-scaled.jpg" data-path="2024/06/ELEMENT-ABC-NGS-Italia-LionDx-scaled.jpg" data-width="2560" data-height="1270" data-singlew="6" data-singleh="" data-crop="" loading="lazy" data-srcset="https://liondx.com/wp-content/uploads/2024/06/ELEMENT-ABC-NGS-Italia-LionDx-scaled.jpg 2560w, https://liondx.com/wp-content/uploads/2024/06/ELEMENT-ABC-NGS-Italia-LionDx-300x149.jpg 300w, https://liondx.com/wp-content/uploads/2024/06/ELEMENT-ABC-NGS-Italia-LionDx-1024x508.jpg 1024w, https://liondx.com/wp-content/uploads/2024/06/ELEMENT-ABC-NGS-Italia-LionDx-768x381.jpg 768w, https://liondx.com/wp-content/uploads/2024/06/ELEMENT-ABC-NGS-Italia-LionDx-1536x762.jpg 1536w, https://liondx.com/wp-content/uploads/2024/06/ELEMENT-ABC-NGS-Italia-LionDx-2048x1016.jpg 2048w, https://liondx.com/wp-content/uploads/2024/06/ELEMENT-ABC-NGS-Italia-LionDx-350x174.jpg 350w, https://liondx.com/wp-content/uploads/2024/06/ELEMENT-ABC-NGS-Italia-LionDx-scaled-uai-720x357.jpg 720w, https://liondx.com/wp-content/uploads/2024/06/ELEMENT-ABC-NGS-Italia-LionDx-scaled-uai-1032x512.jpg 1032w" srcset="data:image/svg+xml;base64,PHN2ZyB3aWR0aD0iMjU2MCIgaGVpZ2h0PSIxMjcwIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxwYXRoIGQ9Ik0wIDBoMXYxSDB6IiBmaWxsPSJub25lIiBmaWxsLXJ1bGU9ImV2ZW5vZGQiLz48L3N2Zz4="></div></div></div></div></div></div></div><div class="empty-space empty-single" ><span class="empty-space-inner"></span></div> <span class="btn-container btn-block" ><a href="https://liondx.com/wp-content/uploads/2024/06/AVITI24_Flyer_A4_General.pdf" class="custom-link btn border-width-0 btn-color-648163 btn-block btn-no-scale btn-icon-left" title="aviti" target="_blank">PIù INFORMAZIONI</a></span></div></div></div></div></div><div class="wpb_column pos-top pos-center align_left column_child col-lg-6 single-internal-gutter"><div class="uncol style-light animate_when_almost_visible bottom-t-top" data-delay="400"><div class="uncoltable"><div class="uncell no-block-padding" ><div class="uncont" ><div class="uncode-single-media text-left"><div class="single-wrapper" style="max-width: 100%;"><a class="single-media-link" href="https://liondx.com/aviti-sequencing-kits-2/" title="AVITI UPGRADE"><div class="tmb tmb-light tmb-media-first tmb-media-last tmb-content-overlay tmb-no-bg"><div class="t-inside"><div class="t-entry-visual"><div class="t-entry-visual-tc"><div class="uncode-single-media-wrapper"><img decoding="async" class="srcset-async srcset-auto wp-image-104859" src="https://liondx.com/wp-content/uploads/2024/06/AVITI-Element-System-Upgrade-scaled.jpg" width="1368" height="2560" alt="" data-no-bp="" data-bp="720,1032" data-uniqueid="104859-146476" data-guid="https://liondx.com/wp-content/uploads/2024/06/AVITI-Element-System-Upgrade-scaled.jpg" data-path="2024/06/AVITI-Element-System-Upgrade-scaled.jpg" data-width="1368" data-height="2560" data-singlew="6" data-singleh="" data-crop="" loading="lazy" data-srcset="https://liondx.com/wp-content/uploads/2024/06/AVITI-Element-System-Upgrade-scaled.jpg 1368w, https://liondx.com/wp-content/uploads/2024/06/AVITI-Element-System-Upgrade-160x300.jpg 160w, https://liondx.com/wp-content/uploads/2024/06/AVITI-Element-System-Upgrade-547x1024.jpg 547w, https://liondx.com/wp-content/uploads/2024/06/AVITI-Element-System-Upgrade-768x1437.jpg 768w, https://liondx.com/wp-content/uploads/2024/06/AVITI-Element-System-Upgrade-821x1536.jpg 821w, https://liondx.com/wp-content/uploads/2024/06/AVITI-Element-System-Upgrade-1094x2048.jpg 1094w, https://liondx.com/wp-content/uploads/2024/06/AVITI-Element-System-Upgrade-350x655.jpg 350w, https://liondx.com/wp-content/uploads/2024/06/AVITI-Element-System-Upgrade-scaled-uai-720x1347.jpg 720w, https://liondx.com/wp-content/uploads/2024/06/AVITI-Element-System-Upgrade-scaled-uai-1032x1931.jpg 1032w" srcset="data:image/svg+xml;base64,PHN2ZyB3aWR0aD0iMTM2OCIgaGVpZ2h0PSIyNTYwIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxwYXRoIGQ9Ik0wIDBoMXYxSDB6IiBmaWxsPSJub25lIiBmaWxsLXJ1bGU9ImV2ZW5vZGQiLz48L3N2Zz4="></div></div></div></div></div></a></div></div></div></div></div></div></div></div></div></div><div class="vc_row row-internal row-container"><div class="row row-child"><div class="wpb_row row-inner"><div class="wpb_column pos-top pos-left align_left column_child col-lg-6 half-internal-gutter"><div class="uncol style-light animate_when_almost_visible bottom-t-top" data-delay="400"><div class="uncoltable"><div class="uncell no-block-padding" ><div class="uncont" ><div class="empty-space empty-single" ><span class="empty-space-inner"></span></div><div class="uncode_text_column" ><p><strong>Doppia flow cell: due sequenziatori in uno </strong><br /> Il cuore pulsante del sequenziatore è la doppia flow cell indipendente, caratteristica che non possiede nessun altro sequenziatore da bancone. AVITI, grazie all’impiego della doppia flow cell indipendente, garantisce un’alta flessibilità operativa e la possibilità di raddoppiare la quantità di dati, aumentando il throughput complessivo.</p></div><div class="uncode_text_column" ><p><strong>Doppia lane indipendente per flow cell: ancora più flessibilità</strong><br /> La flessibilità di AVITI™ è ulteriormente aumentata dalla possibilità di caricamento indipendente delle due lane presenti in ogni singola flow cell. Grazie a ciò è possibile caricare e correre, in modo indipendente e parallelo, esperimenti diversi. Caratteristica unica per un sequenziatore da bancone:</p><ul><li>Upgrade opzionale per consentire il caricamento separato di librerie/pool in ciascuna delle due lane in una singola flow cell</li><li class="p1">Opzioni di multiplexing aumentate</li><li class="p1">Maggiore flessibilità per la variabilità nel throughput del volume dei campioni</li><li class="p1">Maggiore controllo della distribuzione delle read all’interno dei pool</li><li class="p1">Disponibile sia per i sistemi AVITI che AVITI LT</li></ul></div><div class="uncode_text_column" ><p><strong>Le Flow Cell lavorano con chimica Cloudbreak Freestyle™</strong><br /> Esistono tre tipi differenti di flow cell, che impiegano la chimica Cloudbreak Freestyle™, per adattarsi a qualsiasi esigenza: Piccola capacità: soluzione ideale per progetti ridotti e laboratori con pochi campioni, permette il sequenziamento in-house e corse rapide. Media capacità: per progetti e laboratori di dimensioni intermedie, bilancia throughput e costi. Grande capacità: versione perfetta per grandi progetti e laboratori con molti campioni, minimizza il costo/campione.</p></div><div class="empty-space empty-single" ><span class="empty-space-inner"></span></div><div class="uncode-single-media bordo-immagini text-left"><div class="single-wrapper" style="max-width: 100%;"><div class="tmb tmb-light tmb-media-first tmb-media-last tmb-content-overlay tmb-no-bg"><div class="t-inside"><div class="t-entry-visual"><div class="t-entry-visual-tc"><div class="uncode-single-media-wrapper"><img decoding="async" class="srcset-async srcset-auto wp-image-104301" src="https://liondx.com/wp-content/uploads/2024/06/Cloudbreak-chemestry-floe-cell-LionDx-scaled.jpg" width="2560" height="1035" alt="" data-no-bp="" data-bp="720,1032" data-uniqueid="104301-890674" data-guid="https://liondx.com/wp-content/uploads/2024/06/Cloudbreak-chemestry-floe-cell-LionDx-scaled.jpg" data-path="2024/06/Cloudbreak-chemestry-floe-cell-LionDx-scaled.jpg" data-width="2560" data-height="1035" data-singlew="6" data-singleh="" data-crop="" loading="lazy" data-srcset="https://liondx.com/wp-content/uploads/2024/06/Cloudbreak-chemestry-floe-cell-LionDx-scaled.jpg 2560w, https://liondx.com/wp-content/uploads/2024/06/Cloudbreak-chemestry-floe-cell-LionDx-300x121.jpg 300w, https://liondx.com/wp-content/uploads/2024/06/Cloudbreak-chemestry-floe-cell-LionDx-1024x414.jpg 1024w, https://liondx.com/wp-content/uploads/2024/06/Cloudbreak-chemestry-floe-cell-LionDx-768x311.jpg 768w, https://liondx.com/wp-content/uploads/2024/06/Cloudbreak-chemestry-floe-cell-LionDx-1536x621.jpg 1536w, https://liondx.com/wp-content/uploads/2024/06/Cloudbreak-chemestry-floe-cell-LionDx-2048x828.jpg 2048w, https://liondx.com/wp-content/uploads/2024/06/Cloudbreak-chemestry-floe-cell-LionDx-350x142.jpg 350w, https://liondx.com/wp-content/uploads/2024/06/Cloudbreak-chemestry-floe-cell-LionDx-scaled-uai-720x291.jpg 720w, https://liondx.com/wp-content/uploads/2024/06/Cloudbreak-chemestry-floe-cell-LionDx-scaled-uai-1032x417.jpg 1032w" srcset="data:image/svg+xml;base64,PHN2ZyB3aWR0aD0iMjU2MCIgaGVpZ2h0PSIxMDM1IiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxwYXRoIGQ9Ik0wIDBoMXYxSDB6IiBmaWxsPSJub25lIiBmaWxsLXJ1bGU9ImV2ZW5vZGQiLz48L3N2Zz4="></div></div></div></div></div></div></div><div class="empty-space empty-single" ><span class="empty-space-inner"></span></div><div class="uncode_text_column" ><p><strong>Impareggiabile scalabilità: AVITI™ può crescere in qualunque momento</strong><br /> AVITI™ è disponibile nella versione “full” e in quella LT (Low Throughput), ma lo strumento è sempre lo stesso ed acquisirlo rappresenta un investimento di lunga durata. Infatti, in qualunque momento, dalla versione base si può fare l’upgrade alla versione più avanzata contenendo i costi ed evitando faticosi cambiamenti di strumentazione.</p></div><div class="uncode_text_column" ><p><strong>Prezzi competitivi e prestazioni al top</strong><br /> Element Biosciences, grazie alla sua nuova chimica di sequenziamento Avidity Base Chemistry (ABC), ha cambiato completamente il panorama del Next Generation Sequencing.<br /> <span style="font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen-Sans, Ubuntu, Cantarell, 'Helvetica Neue', sans-serif;">Pur avendo delle prestazioni superiori a quelle dei sequenziatori della stessa categoria ha un costo a campione più basso, paragonabile a quello degli strumenti più processivi sul mercato che richiedono investimenti iniziali di milioni di euro.<br /> </span>Con questa politica dirompente, Element permette ai laboratori di tutte le dimensioni e con ogni budget di fare più scienza.</p></div><div class="uncode_text_column" ><p><strong>Compatibilità universale</strong><br /> Cloudbreak Freestyle™, la chimica di sequenziamento impiegata da AVITI™, è perfettamente compatibile con tutte le librerie attualmente presenti sul mercato, e non necessita di alcuna conversione. Questo garantisce che i laboratori non debbano cambiare nulla della loro routine operativa o effettuare ulteriori acquisti.</p></div></div></div></div></div></div><div class="wpb_column pos-top pos-center align_left column_child col-lg-6 single-internal-gutter"><div class="uncol style-light animate_when_almost_visible bottom-t-top" data-delay="400"><div class="uncoltable"><div class="uncell no-block-padding" ><div class="uncont" ><div class="uncode-single-media text-left"><div class="single-wrapper" style="max-width: 100%;"><div class="tmb tmb-light tmb-media-first tmb-media-last tmb-content-overlay tmb-no-bg"><div class="t-inside"><div class="t-entry-visual"><div class="t-entry-visual-tc"><div class="uncode-single-media-wrapper"><img decoding="async" class="srcset-async srcset-auto wp-image-104300" src="https://liondx.com/wp-content/uploads/2024/06/AVITI-individually-addressable-lanes.jpg" width="1543" height="1755" alt="" data-no-bp="" data-bp="720,1032" data-uniqueid="104300-157360" data-guid="https://liondx.com/wp-content/uploads/2024/06/AVITI-individually-addressable-lanes.jpg" data-path="2024/06/AVITI-individually-addressable-lanes.jpg" data-width="1543" data-height="1755" data-singlew="6" data-singleh="" data-crop="" loading="lazy" data-srcset="https://liondx.com/wp-content/uploads/2024/06/AVITI-individually-addressable-lanes.jpg 1543w, https://liondx.com/wp-content/uploads/2024/06/AVITI-individually-addressable-lanes-264x300.jpg 264w, https://liondx.com/wp-content/uploads/2024/06/AVITI-individually-addressable-lanes-900x1024.jpg 900w, https://liondx.com/wp-content/uploads/2024/06/AVITI-individually-addressable-lanes-768x874.jpg 768w, https://liondx.com/wp-content/uploads/2024/06/AVITI-individually-addressable-lanes-1350x1536.jpg 1350w, https://liondx.com/wp-content/uploads/2024/06/AVITI-individually-addressable-lanes-350x398.jpg 350w, https://liondx.com/wp-content/uploads/2024/06/AVITI-individually-addressable-lanes-uai-720x819.jpg 720w, https://liondx.com/wp-content/uploads/2024/06/AVITI-individually-addressable-lanes-uai-1032x1174.jpg 1032w" srcset="data:image/svg+xml;base64,PHN2ZyB3aWR0aD0iMTU0MyIgaGVpZ2h0PSIxNzU1IiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxwYXRoIGQ9Ik0wIDBoMXYxSDB6IiBmaWxsPSJub25lIiBmaWxsLXJ1bGU9ImV2ZW5vZGQiLz48L3N2Zz4="></div></div></div></div></div></div></div><div class="uncode_text_column" ><p>Le due lane all’interno della flow cell</p></div><div class="empty-space empty-single" ><span class="empty-space-inner"></span></div> <span class="btn-container btn-block" ><a href="https://liondx.com/wp-content/uploads/2024/06/Aviti_System_Brochure_LionDx-DIGIT-NEW.pdf" class="custom-link btn border-width-0 btn-color-648163 btn-block btn-no-scale btn-icon-left" title="AVITI" target="_blank">SCARICA LA BROCHURE</a></span><span class="btn-container btn-block" ><a href="https://liondx.com/wp-content/uploads/2024/11/Aviti-24_System_Brochure_LionDx.pdf" class="custom-link btn border-width-0 btn-color-648163 btn-block btn-no-scale btn-icon-left" title="AVITI24" target="_blank">SCOPRI AVITI24</a></span><span class="btn-container btn-block" ><a href="https://liondx.com/wp-content/uploads/2024/11/Utility-analyses-of-AVITI-sequencing-chemistry.pdf" class="custom-link btn border-width-0 btn-color-648163 btn-block btn-no-scale btn-icon-left" title="AVITI COMPARAZIONE CON ILLUMINA NEXT SEQ 550" target="_blank">STUDIO: COMPARAZIONE CON ILLUMINA NEXT SEQ 550</a></span><span class="btn-container btn-block" ><a href="https://liondx.com/wp-content/uploads/2024/11/Sequencing-by-avidity-enables-high-accuracy-with-low-reagent-consumption.pdf" class="custom-link btn border-width-0 btn-color-648163 btn-block btn-no-scale btn-icon-left" title="AVITI BASSO CONSUMO DI REAGENTI" target="_blank">STUDIO: ACCURATEZZA E BASSO CONSUMO DI REAGENTI</a></span><span class="btn-container btn-block" ><a href="https://liondx.com/aviti-sequencing-kits-2/" class="custom-link btn border-width-0 btn-color-648163 btn-block btn-no-scale btn-icon-left" title="AVITI Sequencing Kits" target="_blank">AVITI sequencing Kits</a></span></div></div></div></div></div></div></div></div><div class="vc_row row-internal row-container"><div class="row row-child"><div class="wpb_row row-inner"><div class="wpb_column pos-top pos-left align_left column_child col-lg-12 half-internal-gutter"><div class="uncol style-light animate_when_almost_visible bottom-t-top" data-delay="400"><div class="uncoltable"><div class="uncell no-block-padding" ><div class="uncont" ><div class="uncode-single-media bordo-immagini text-left"><div class="single-wrapper" style="max-width: 100%;"><div class="tmb tmb-light tmb-media-first tmb-media-last tmb-content-overlay tmb-no-bg"><div class="t-inside"><div class="t-entry-visual"><div class="t-entry-visual-tc"><div class="uncode-single-media-wrapper"><img decoding="async" class="srcset-async srcset-auto wp-image-104302" src="https://liondx.com/wp-content/uploads/2024/06/AVITI-Cloudbreak-Freestyle-Illumina-scaled.jpg" width="2560" height="1217" alt="" data-no-bp="" data-bp="720,1032" data-uniqueid="104302-123659" data-guid="https://liondx.com/wp-content/uploads/2024/06/AVITI-Cloudbreak-Freestyle-Illumina-scaled.jpg" data-path="2024/06/AVITI-Cloudbreak-Freestyle-Illumina-scaled.jpg" data-width="2560" data-height="1217" data-singlew="12" data-singleh="" data-crop="" loading="lazy" data-srcset="https://liondx.com/wp-content/uploads/2024/06/AVITI-Cloudbreak-Freestyle-Illumina-scaled.jpg 2560w, https://liondx.com/wp-content/uploads/2024/06/AVITI-Cloudbreak-Freestyle-Illumina-300x143.jpg 300w, https://liondx.com/wp-content/uploads/2024/06/AVITI-Cloudbreak-Freestyle-Illumina-1024x487.jpg 1024w, https://liondx.com/wp-content/uploads/2024/06/AVITI-Cloudbreak-Freestyle-Illumina-768x365.jpg 768w, https://liondx.com/wp-content/uploads/2024/06/AVITI-Cloudbreak-Freestyle-Illumina-1536x730.jpg 1536w, https://liondx.com/wp-content/uploads/2024/06/AVITI-Cloudbreak-Freestyle-Illumina-2048x973.jpg 2048w, https://liondx.com/wp-content/uploads/2024/06/AVITI-Cloudbreak-Freestyle-Illumina-350x166.jpg 350w, https://liondx.com/wp-content/uploads/2024/06/AVITI-Cloudbreak-Freestyle-Illumina-scaled-uai-720x342.jpg 720w, https://liondx.com/wp-content/uploads/2024/06/AVITI-Cloudbreak-Freestyle-Illumina-scaled-uai-1032x491.jpg 1032w" srcset="data:image/svg+xml;base64,PHN2ZyB3aWR0aD0iMjU2MCIgaGVpZ2h0PSIxMjE3IiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxwYXRoIGQ9Ik0wIDBoMXYxSDB6IiBmaWxsPSJub25lIiBmaWxsLXJ1bGU9ImV2ZW5vZGQiLz48L3N2Zz4="></div></div></div></div></div></div></div><div class="empty-space empty-single" ><span class="empty-space-inner"></span></div><div class="uncode-single-media bordo-immagini text-left"><div class="single-wrapper" style="max-width: 100%;"><div class="tmb tmb-light tmb-media-first tmb-media-last tmb-content-overlay tmb-no-bg"><div class="t-inside"><div class="t-entry-visual"><div class="t-entry-visual-tc"><div class="uncode-single-media-wrapper"><img decoding="async" class="srcset-async srcset-auto wp-image-104303" src="https://liondx.com/wp-content/uploads/2024/06/Element-avidite-molecules-RCA-Sequencing-scaled.jpg" width="2560" height="1495" alt="" data-no-bp="" data-bp="720,1032" data-uniqueid="104303-499037" data-guid="https://liondx.com/wp-content/uploads/2024/06/Element-avidite-molecules-RCA-Sequencing-scaled.jpg" data-path="2024/06/Element-avidite-molecules-RCA-Sequencing-scaled.jpg" data-width="2560" data-height="1495" data-singlew="12" data-singleh="" data-crop="" loading="lazy" data-srcset="https://liondx.com/wp-content/uploads/2024/06/Element-avidite-molecules-RCA-Sequencing-scaled.jpg 2560w, https://liondx.com/wp-content/uploads/2024/06/Element-avidite-molecules-RCA-Sequencing-300x175.jpg 300w, https://liondx.com/wp-content/uploads/2024/06/Element-avidite-molecules-RCA-Sequencing-1024x598.jpg 1024w, https://liondx.com/wp-content/uploads/2024/06/Element-avidite-molecules-RCA-Sequencing-768x449.jpg 768w, https://liondx.com/wp-content/uploads/2024/06/Element-avidite-molecules-RCA-Sequencing-1536x897.jpg 1536w, https://liondx.com/wp-content/uploads/2024/06/Element-avidite-molecules-RCA-Sequencing-2048x1196.jpg 2048w, https://liondx.com/wp-content/uploads/2024/06/Element-avidite-molecules-RCA-Sequencing-350x204.jpg 350w, https://liondx.com/wp-content/uploads/2024/06/Element-avidite-molecules-RCA-Sequencing-scaled-uai-720x420.jpg 720w, https://liondx.com/wp-content/uploads/2024/06/Element-avidite-molecules-RCA-Sequencing-scaled-uai-1032x603.jpg 1032w" srcset="data:image/svg+xml;base64,PHN2ZyB3aWR0aD0iMjU2MCIgaGVpZ2h0PSIxNDk1IiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjxwYXRoIGQ9Ik0wIDBoMXYxSDB6IiBmaWxsPSJub25lIiBmaWxsLXJ1bGU9ImV2ZW5vZGQiLz48L3N2Zz4="></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div><div class="empty-space empty-single" ><span class="empty-space-inner"></span></div></div></div></div></div></div><script id="script-row-unique-2" data-row="script-row-unique-2" type="text/javascript" class="vc_controls">UNCODE.initRow(document.getElementById("row-unique-2"));</script></div></div></div><div data-parent="true" class="vc_row style-color-lxmt-bg row-container onepage-section" data-label="neonatale" data-name="neonatale" id="row-unique-3"><div class="row double-top-padding double-bottom-padding triple-h-padding full-width row-parent"><div class="wpb_row row-inner"><div class="wpb_column pos-top pos-left align_left column_parent col-lg-6 single-internal-gutter"><div class="uncol style-light animate_when_almost_visible bottom-t-top" data-delay="300"><div class="uncoltable"><div class="uncell no-block-padding" ><div class="uncont" ><div class="vc_custom_heading_wrap "><div class="heading-text el-text" ><h3 class="fontheight-162334 font-weight-600 text-accent-color" ><span>Aviti. Your science can’t wait!</span></h3></div><div class="clear"></div></div><div class="vc_custom_heading_wrap "><div class="heading-text el-text" ><h4 class="h4 fontheight-162334 font-weight-600 text-color-648163-color" ><span>Clicca sulle domande per ottenere le risposte</span></h4></div><div class="clear"></div></div><div class="uncode-accordion wpb_accordion wpb_content_element sign-size-rg w-border" data-collapsible="no" data-target="" data-active-tab="0" ><div class="panel-group wpb_wrapper wpb_accordion_wrapper" id="accordion_167748930" role="tablist" aria-multiselectable="true" data-no-toggle=""><div class="panel panel-default wpb_accordion_section group"><div class="panel-heading wpb_accordion_header ui-accordion-header" role="tab"><p class="panel-title font-weight- text- icon-size-rg"><a data-toggle="collapse" data-parent="#accordion_167748930" href="#1689846304933-15-6"><span>CHI È ELEMENT BIOSCIENCES?</span></a></p></div><div id="1689846304933-15-6" class="panel-collapse collapse" role="tabpanel"><div class="panel-body wpb_accordion_content ui-accordion-content half-internal-gutter single-block-padding"><div class="uncode_text_column" ><p>Element Biosciences, fondata in California nel 2017 da un team di ex-dirigenti di Illumina, è comparsa sul mercato nel 2022 ed è passata dall’idea allo strumento in soli 5 anni ottenendo oltre 400 milioni di dollari di finanziamenti. Negli ultimi 2 anni è cresciuta esponenzialmente e ha dato avvio a una vera e propria rivoluzione nel mondo del sequenziamento, sia sotto il profilo tecnico-scientifico sia sotto il profilo economico.</p></div></div></div></div><div class="panel panel-default wpb_accordion_section group"><div class="panel-heading wpb_accordion_header ui-accordion-header" role="tab"><p class="panel-title font-weight- text- icon-size-rg"><a data-toggle="collapse" data-parent="#accordion_167748930" href="#1682607896-1-9616894281727761689428277407"><span>QUALI SONO I VANTAGGI DI DUE FLOW CELL, CIASCUNA DELLE QUALI CONTENETE UNA DOPPIA LANE?</span></a></p></div><div id="1682607896-1-9616894281727761689428277407" class="panel-collapse collapse" role="tabpanel"><div class="panel-body wpb_accordion_content ui-accordion-content half-internal-gutter single-block-padding"><div class="uncode_text_column" ><p>La presenza di una doppia flow cell indipendente nel sistema AVITI™ aumenta notevolmente la capacità di sequenziamento, la flessibilità operativa, e l’efficienza economica, rendendo il sistema di NGS messo a punto da Element la migliore soluzione da benchtop.</p><p class="p1"><span class="s1"><b>Maggiore Capacità di Sequenziamento. </b></span>Ogni flow cell lavora in parallelo e in modo indipendente. Questo permette di raddoppiare la quantità di dati generata in un solo ciclo di sequenziamento.</p><p class="p1"><span class="s1"><b>Flessibilità Operativa. </b>L</span>a possibilità di caricare in modo indipendente librerie o pool diversi in ciascuna delle due lane permette di gestire campioni multipli con esigenze diverse nello stesso run di sequenziamento.<br /> Adattabilità ai Progetti:è possibile sequenziare campioni differenti o utilizzare condizioni differenti per ciascuna flow cell, adattando il processo alle specifiche necessità del progetto.</p><p class="p1"><span class="s1"><b>Efficienza Economica. </b></span>Ottimizzazione dei reagenti: l’uso di due flow cell in parallelo aiuta ad ottimizzare l’uso dei reagenti, specialmente con un elevato numero di campioni.<br /> <b>Riduzione del tempo di esecuzione:</b> l’operatività simultanea di entrambe le flow cell riduce i tempi di esecuzione per grandi volumi di dati, permettendo una più rapida acquisizione dei risultati.</p><p class="p1"><span class="s1"><b>Maggiore Controllo della Distribuzione delle Read.</b> </span>Con due flow cell è possibile avere maggiore controllo sulla distribuzione delle read all’interno di ogni pool, ciò migliora la qualità dei dati e ottimizza l’uso del sequenziatore.</p><p><b>Minimizzazione delle Contaminazioni:</b> la separazione fisica delle lane in due flow cell riduce il rischio di contaminazione tra diversi campioni o pool.</p><p class="p1"><span class="s1"><b>Aumento del Multiplexing.</b> </span>Gestire lane separate, in una singola corsa di sequenziamento, permette di utilizzare una gamma più ampia di combinazioni di multiplexing e offre una maggiore versatilità nel disegno degli esperimenti.</p></div></div></div></div><div class="panel panel-default wpb_accordion_section group"><div class="panel-heading wpb_accordion_header ui-accordion-header" role="tab"><p class="panel-title font-weight- text- icon-size-rg"><a data-toggle="collapse" data-parent="#accordion_167748930" href="#1689846366145-16-3"><span>QUALI SONO I POSSIBILI ESEMPI DI UTILIZZO?</span></a></p></div><div id="1689846366145-16-3" class="panel-collapse collapse" role="tabpanel"><div class="panel-body wpb_accordion_content ui-accordion-content half-internal-gutter single-block-padding"><div class="uncode_text_column" ><p class="p1"><b>Attività di sequenziamento diversificate: </b>in un lavoro che coinvolge campioni di diverse origini o condizioni sperimentali, ogni flow cell può essere dedicata a un preciso set di campioni, permettendo un’analisi più mirata e riducendo la necessità di eseguire run separati.</p><p><b>Sequenziamento rapido:</b> per laboratori con elevati volumi di sequenziamento o scadenze ravvicinate, l’uso della doppia flow cell consente un incremento significativo nella produttività e nel turnaround time.</p></div></div></div></div><div class="panel panel-default wpb_accordion_section group"><div class="panel-heading wpb_accordion_header ui-accordion-header" role="tab"><p class="panel-title font-weight- text- icon-size-rg"><a data-toggle="collapse" data-parent="#accordion_167748930" href="#1682607896-2-3816894281727761689428277407"><span>QUALI SONO I PRINCIPALI VANTAGGI DEL SISTEMA AVITI™?</span></a></p></div><div id="1682607896-2-3816894281727761689428277407" class="panel-collapse collapse" role="tabpanel"><div class="panel-body wpb_accordion_content ui-accordion-content half-internal-gutter single-block-padding"><div class="uncode_text_column" ><p class="p1"><span class="s1"><b>Alta Accuratezza (Q40+):</b></span> fornisce un Q-score di 40 o superiore, il che equivale a un tasso di errore in sequenziamento estremamente basso (meno di 1 errore su 10.000 basi).</p><p class="p1"><b>Elevata affidabilità dei dati:</b> di fondamentale importanza in applicazioni critiche come la medicina di precisione e la ricerca genetica.</p><p class="p1"><span class="s1"><b>Doppia Flow Cell. </b></span><b>Aumento del Throughput:</b> la configurazione con due flow cell permette di processare simultaneamente due set di campioni, raddoppiando il throughput rispetto a sistemi a flow cell singola.</p><p class="p1"><b>Flessibilità Operativa:</b> consente l’esecuzione di diverse condizioni o set di librerie in parallelo, ottimizzando il carico di lavoro e migliorando l’efficienza.</p><p class="p1"><span class="s1"><b>Compatibilità Universale con le Librerie.</b> L</span>a chimica Cloudbreak Freestyle™ è compatibile con tutte le librerie di sequenziamento disponibili sul mercato, eliminando la necessità di sviluppare o acquistare nuovi kit specifici per il sistema.</p><p class="p1"><b>Adattabilità:</b> facilita l’integrazione nei flussi di lavoro esistenti senza richiedere cambiamenti significativi.</p><p class="p1"><span class="s1"><b>Efficienza Economica.</b> </span>Ottimizza l’uso dei reagenti e minimizza i costi operativi, rendendo il sequenziamento più accessibile anche per i laboratori con budget limitati.</p><p class="p1"><b>Per laboratori di tutte le dimensioni</b>, dai piccoli laboratori a quelli di ricerca di grandi dimensioni.</p><p class="p1"><span class="s1"><b>Sequenziamento In-House.</b> </span>Offre capacità avanzate di sequenziamento in un formato da banco, permettendo ai laboratori di eseguire sequenziamenti in-house piuttosto che esternalizzare a servizi di sequenziamento, riducendo i tempi di attesa per i risultati.</p><p class="p1"><span class="s1"><b>Facilità d’Uso e di Manutenzione. </b>AVITI™ </span>si avvale di un’interfaccia, molto intuitiva, è progettata per essere user-friendly.<br /> Di facile manutenzione con tempi di inattività dello strumento ridotti al minimo.</p><p class="p1"><span class="s1"><b>Scalabile e Modulare.</b> </span>AVITI™ permette di scalare il throughput e di estendere la lunghezza delle read agevolando l’attività<span class="Apple-converted-space"> </span>dell’operatore con massima versatilità ai diversi tipi di progetto.</p><p><b>Lo strumento può “crescere”</b> dal livello Base: AVITI LT (Low Throughput) allo strumento nella versione “full” risultando un investimento molto lungimirante.<span class="Apple-converted-space"> </span></p><p class="p1"><span class="s1"><b>Ampia Gamma di Applicazioni del Next Generation Sequencing.</b> </span>Supporta un’ampia gamma di applicazioni di NGS, tra cui Whole Exome Sequencing (WES), Whole Genome Sequencing (WGS), bulk RNAseq e Single Cell, metatrascrittomica e metabarcoding<span class="s2">.</span></p><p class="p1"><span class="s1"><b>Ecosistema Completo.</b> </span>AVITI™ garantisce un Supporto Software avanzato per analisi e gestione dei dati, oltre che un Supporto Hardware robusto che assicura un funzionamento fluido e integrato dello strumento.</p></div></div></div></div><div class="panel panel-default wpb_accordion_section group"><div class="panel-heading wpb_accordion_header ui-accordion-header" role="tab"><p class="panel-title font-weight- text- icon-size-rg"><a data-toggle="collapse" data-parent="#accordion_167748930" href="#1682608034443-2-216894281727761689428277407"><span>PERCHÉ CON AVITI SI RIDUCONO I COSTI?</span></a></p></div><div id="1682608034443-2-216894281727761689428277407" class="panel-collapse collapse" role="tabpanel"><div class="panel-body wpb_accordion_content ui-accordion-content half-internal-gutter single-block-padding"><div class="uncode_text_column" ><p class="p1"><span class="s1"><b>Ottimizzazione del Consumo di Reagenti</b>. </span>AVITI™ si avvale della chimica Cloudbreak Freestyle™ ed è studiato per impiegare quantità minime di reagenti e ridurre al minimo gli sprechi.</p><p class="p1"><span class="s1"><b>Compatibilità con Librerie Esistenti.</b> </span>Grazie alla compatibilità universale del Sistema AVITI™, i laboratori possono continuare a utilizzare i loro kit preferiti senza costi aggiuntivi per nuovi acquisti o adattamenti.</p><p class="p1"><span class="s1"><b>Dual Flow Cell.</b> </span>La possibilità di utilizzare due flow cell contemporaneamente in modo indipendente raddoppia il throughput e riduce il costo per campione.</p><p class="p1"><span class="s1"><b>Accuratezza Elevata (Q40+).</b> </span>L’alta precisione (Q40+) riduce la necessità di ripetere esperimenti per ottenere dati accurati, abbattendo i costi di rielaborazione e reagenti aggiuntivi.</p><p class="p1"><span class="s1"><b>Manutenzione Ridotta e Lunga Durata.</b> </span>Il sistema, user-friendly, è progettato per richiedere una manutenzione minima, il che si traduce in minime interruzioni operative e costi di manutenzione ridotti. Inoltre, la robustezza del sistema AVITI™ riduce i guasti abbattendo i costi di riparazione e sostituzione.</p><p class="p1"><span class="s1"><b>Sequenziamento In-House e Tempi Ridotti.</b> </span>Fornendo una soluzione da banco, consente ai laboratori di eseguire sequenziamenti in-house, eliminando i costi legati all’outsourcing e ai lungi tempi di attesa per il risultato.</p><p class="p1"><span class="s1"><b>Flessibilità e Scalabilità. </b></span>Il sistema permette di scalare il throughput e la lunghezza delle read in base alle necessità del progetto, anche questo concorre ad ottimizzare l’uso delle risorse riducendo il costo/campione in progetti di diversa scala.</p></div></div></div></div><div class="panel panel-default wpb_accordion_section group"><div class="panel-heading wpb_accordion_header ui-accordion-header" role="tab"><p class="panel-title font-weight- text- icon-size-rg"><a data-toggle="collapse" data-parent="#accordion_167748930" href="#1682608063291-3-016894281727761689428277407"><span>QUALI SONO LE DIFFERENZE FRA SBS (SEQUENCING BY SYNTHESIS) E L’ABC (AVIDITY BASE CHEMISTRY), ADOTTATA DA ELEMENT?</span></a></p></div><div id="1682608063291-3-016894281727761689428277407" class="panel-collapse collapse" role="tabpanel"><div class="panel-body wpb_accordion_content ui-accordion-content half-internal-gutter single-block-padding"><div class="uncode_text_column" ><p>La Avidity Base Chemistry (ABC) rappresenta un progresso significativo nel campo del sequenziamento. L’ABC non solo riduce i costi rispetto alla SBS, ma migliora anche la qualità e la versatilità del sequenziamento, rendendo questa tecnologia un’opzione più accessibile e affidabile per i laboratori di diverse dimensioni e necessità.</p><p class="p2"><b>Efficienza dei Reagenti:</b> ABC richiede meno reagenti rispetto a SBS, riducendo i costi.</p><p class="p1"><b>Qualità dei Dati: </b>il sistema offre una qualità dei dati superiore con una minore propagazione degli errori</p><p><b>Compatibilità:</b> è compatibile con un’ampia gamma di librerie, mentre SBS può richiedere kit specifici.</p><p class="p1"><b>Flessibilità Operativa:</b> consente una maggiore flessibilità operativa, facilitando l’uso in vari contesti di laboratorio.</p></div></div></div></div><div class="panel panel-default wpb_accordion_section group"><div class="panel-heading wpb_accordion_header ui-accordion-header" role="tab"><p class="panel-title font-weight- text- icon-size-rg"><a data-toggle="collapse" data-parent="#accordion_167748930" href="#1685626606884-11-1016894281727761689428277407"><span>COME FA AVITI A CONTENERE AL MINIMO L’ERRORE, OFFRENDO UN Q-SCORE DI 40 O SUPERIORE?</span></a></p></div><div id="1685626606884-11-1016894281727761689428277407" class="panel-collapse collapse" role="tabpanel"><div class="panel-body wpb_accordion_content ui-accordion-content half-internal-gutter single-block-padding"><div class="uncode_text_column" ><p class="p1">Il sistema AVITI™ riesce a contenere al minimo l’errore e garantire un Q-score di 40 o superiore grazie a diversi fattori chiave che migliorano la precisione del sequenziamento:</p><p class="p2"><b>Tecnologia di Sequenziamento Avanzata. </b>AVITI™ utilizza la tecnologia Avidity Base Chemistry (ABC), che impiega le avidine per il rilevamento delle basi. Questa metodologia permette una lettura stabile e affidabile delle basi del DNA durante il processo di sequenziamento.</p><p class="p3"><b>RCA e Polonies:</b> l’uso della Rolling Circle Amplification (RCA) contribuisce a mantenere l’integrità del template originale, riducendo la propagazione degli errori durante l’amplificazione e la generazione dei polonies.</p><p class="p2"><b>Separazione delle Fasi di Rilevamento e Avanzamento.</b> AVITI™ separa chiaramente le fasi di rilevamento delle basi e avanzamento del template. Questo approccio ottimizza l’efficienza delle condizioni enzimatiche per ciascuna fase, minimizzando la possibilità di errori durante l’incorporazione dei nucleotidi.</p><p class="p3"><span class="s1"><b>Minimizzazione degli Errori di Sequenziamento.</b> </span>Bassa Concentrazione di Reagenti: utilizza concentrazioni nanomolari di reagenti, riducendo, oltre ai costi, la probabilità di errori durante l’incorporazione dei nucleotidi e migliorando la specificità del rilevamento.</p><p class="p3"><span class="s1"><b>Alta Qualità dei Dati.</b> </span>Eliminazione degli Errori di PCR: a differenza della generazione dei cluster nella SBS tradizionale, AVITI utilizza la RCA (Rolling circle amplification) evitando la propagazione di errori associati alla PCR e migliorando la fedeltà del sequenziamento.</p><p class="p1"><b>Benefici per l’Utente.</b> Questi elementi combinati consentono ad AVITI di sequenziare con un Q-score di 40 o superiore, il che si traduce in un tasso di errore estremamente basso (meno di 1 errore su 10.000 basi sequenziate). 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