Leveraging Electronic Health Information to Advance Precision Medicine (LEAP)

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href="/resources/ORD_Admin/default.cfm">Admin Resources Home</a></li> <li><a href="/resources/ORD_Admin/ord_contacts.cfm">Central Office Contacts</a></li> <li><a href="/resources/ORD_Admin/clinical_trials.cfm">Clinical Trials Registration and Submission</a></li> <li><a href="/resources/ORD_Admin/congressional_info.cfm">Congressional Requests</a></li> <li><a href="/resources/ORD_Admin/field_conference.cfm">Field Conference Calls</a></li> <li><a href="/resources/frac/default.cfm">Field Research Advisory Committee</a></li> </ul> </li> </ul> </nav> </div>   <div id="left-col-content"> </div>   </div>   <div id="innerContentWrapper" style="position: relative; "> <div class="clear"></div> <span style="position:absolute;"><a name="main-content" id="main-content"></a></span> <div class="clear"></div> <div id="tier4innerContent" style="border:0px solid green;">  <h2 class="page-title">Leveraging Electronic Health Information to Advance Precision Medicine (LEAP)</h2>  <p>LEAP experts from several VA medical centers and academic institutions harness “Big” electronic health and other national data sources to provide real-world evidence about pressing health issues. LEAP uses novel methods on the Veterans Health Administration’s electronic health data, the longest-running and largest U.S. electronic health records system, to inform population health outcomes, individual precision health, healthcare system management, and quality in clinical practice.</p> <p>LEAP is a national data initiative and a multi-site collaboration comprised of data scientists, biostatisticians, epidemiologists, informaticians, and clinical leadership partners. The VA’s extensive health information archive offers a rich opportunity to develop Precision Medicine–based strategies that can be implemented in pragmatic and attainable ways. LEAP advances national precision medicine initiatives, which leverages large-scale information to customize medical treatments based on a patient’s genetic history, environment, and lifestyle. LEAP utilizes existing large data sources to augment and support the strategic planning, conduct, generalizability, and impact of multi-site randomized clinical trials. Recent work has included a focus on research related to glycemic dysregulation, cardiometabolic conditions, cancers, and COVID-19.</p> <h4>Objectives of LEAP</h4> <ul> <li>Establishing a quality real-world evidence (RWE) base about health conditions, populations, interventions, and outcomes using VA EHR.</li> <li>Augment and support Randomized Clinical Trials (RCTs) to improve individual and population health.</li> </ul> <h4>Ongoing Observational Real-World Evidence Exemplars </h4> <ul> <li>Pre-diabetes detection and management</li> <li>Longitudinal progression of glycemic dysregulation</li> <li>Metformin prescribing patterns in pre-diabetes</li> <li>SARS-CoV-2 infection and outcomes in patients with glycemic dysregulation</li> </ul> <h4>Key Personnel</h4> <p>Jennifer Lee, MD, PhD & Mei-Chiung Shih, PhD (Co-Chairs, VA Palo Alto Health Care System)</p> <p>Natalie Fullenkamp, MA (LEAP National Coordinator, VA Palo Alto Health Care System)</p> <p>Mihaela Aslan, PhD (LEAP Coordinating Center Director (Acting), West Haven CSP Epidemiology Center, VA Connecticut Healthcare System)</p> <p>Julie Lynch, PhD & Kyung Lee, PhD (Co-Investigators, VA Salt Lake City)</p> <p>Patricia Crutchfield (Program Manager, VA Connecticut Healthcare System)</p> <h4>Sponsorship</h4> <p>This project is sponsored by the Department of Veterans Affairs Cooperative Studies Program.</p> <h4>Contact</h4> <p>Contact the <a href="mailto:Natalie.Fullenkamp@va.gov">National Coordinator</a>, Natalie Fullenkamp, for more information.</p> <div class="clear"></div> </div>   <br style="clear: both" /> <br clear="all">  <div style="bottom:0; margin-left:30px; margin-top:30px; font-weight:bold; padding-top:10px; border-top:1px solid #cccccc;" id="footerBlock"> Questions about the R&D website? <a href="mailto:HSRDWeb.Boston@va.gov" style="color:#0B6CB2 !Important;">Email the Web Team</a> <span style="font-size:10px; font-weight:normal;"> <br> <br> Any health information on this website is strictly for informational purposes and is not intended as medical advice. 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Leveraging Electronic Health Information to Advance Precision Medicine (LEAP)