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class="elementor-background-video-hosted" autoplay muted playsinline loop></video> </div><div class="elementor-element elementor-element-56067eb4 e-con-full e-flex e-con e-child" data-id="56067eb4" data-element_type="container"> <div class="elementor-element elementor-element-5d8273c elementor-widget elementor-widget-heading" data-id="5d8273c" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Applications</h2> </div> </div> <div class="elementor-element elementor-element-2f47598 elementor-widget elementor-widget-heading" data-id="2f47598" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h1 class="elementor-heading-title elementor-size-default">Model Mass Transfer, Multiphase Fluid Flow & More in Bioreactors</h1> </div> </div> <div class="elementor-element elementor-element-5aec2983 elementor-widget elementor-widget-text-editor" data-id="5aec2983" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> Most biologic processes are developed in lab-scale tabletop bioreactors with small operating volumes. M-Star CFD helps you scale up processes from lab-scale to production-scale build with greater speed and fidelity than ever before. </div> </div> <div class="elementor-element elementor-element-5cb186fb e-con-full e-flex e-con e-child" data-id="5cb186fb" data-element_type="container"> <div class="elementor-element elementor-element-0a774b4 elementor-widget elementor-widget-button" data-id="0a774b4" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="https://mstarcfd.com/contact/"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">Get Started</span> </span> </a> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-6ae1597b e-con-full elementor-hidden-tablet elementor-hidden-mobile e-flex e-con e-child" data-id="6ae1597b" data-element_type="container"> </div> </div> </div> <div class="elementor-element elementor-element-10cb713 e-flex e-con-boxed e-con e-parent" data-id="10cb713" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-5cd5f40 e-con-full e-flex e-con e-child" data-id="5cd5f40" data-element_type="container"> <div class="elementor-element elementor-element-7d2a258 elementor-widget elementor-widget-heading" data-id="7d2a258" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">CFD Modeling Capabilities for Bioreactors</h2> </div> </div> <div class="elementor-element elementor-element-ba5bb7b elementor-widget elementor-widget-text-editor" data-id="ba5bb7b" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> M-Star CFD was built to handle simulations with millions of grid points and millions of individually tracked bubbles. This allows you to model complex bioreactor physics problems—including mass transfer, multiphase fluid flow, and more—accurately and in minutes. </div> </div> </div> <div class="elementor-element elementor-element-80a2b99 e-con-full e-flex e-con e-child" data-id="80a2b99" data-element_type="container"> <div class="elementor-element elementor-element-1de2009 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list" data-id="1de2009" data-element_type="widget" data-widget_type="icon-list.default"> <div class="elementor-widget-container"> <ul class="elementor-icon-list-items"> <li class="elementor-icon-list-item"> <span class="elementor-icon-list-icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 106 73"><defs><style> .cls-1 { fill: #2ec99b; } </style></defs><g><g id="Layer_1"><path id="Combined_Shape" class="cls-1" 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</span> <span class="elementor-icon-list-text">Gas Hold-Up</span> </li> <li class="elementor-icon-list-item"> <span class="elementor-icon-list-icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 88 88"><defs><style> .cls-1 { fill: #2ec99b; } </style></defs><g><g id="Layer_1"><path id="Combined_Shape" class="cls-1" 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class="elementor-icon-list-item"> <span class="elementor-icon-list-icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 108 100"><defs><style> .cls-1 { fill: #2ec99b; } </style></defs><g><g id="Layer_1"><path id="Combined_Shape" class="cls-1" 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</span> <span class="elementor-icon-list-text">Reactions</span> </li> <li class="elementor-icon-list-item"> <span class="elementor-icon-list-icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 92 88"><defs><style> .cls-1 { fill: #2ec99b; } </style></defs><g><g id="Layer_1"><path id="Combined_Shape" class="cls-1" 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</span> <span class="elementor-icon-list-text">Bubble Break-Up Coalescence</span> </li> </ul> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-7907d1b4 e-flex e-con-boxed e-con e-parent" data-id="7907d1b4" data-element_type="container"> <div class="e-con-inner"> <div class="elementor-element elementor-element-227fed54 e-con-full e-flex e-con e-child" data-id="227fed54" data-element_type="container"> <div class="elementor-element elementor-element-5cbeb82 elementor-widget elementor-widget-heading" data-id="5cbeb82" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Latest Resources</h2> </div> </div> <div class="elementor-element elementor-element-779d382f elementor-widget elementor-widget-heading" data-id="779d382f" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 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e-grid e-con-boxed e-con e-child" data-id="13bb2e8" data-element_type="container"> <div class="e-con-inner"> <div class="elementor-element elementor-element-d399034 e-con-full e-flex e-con e-child" data-id="d399034" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="elementor-element elementor-element-3aed35f e-con-full e-flex e-con e-child" data-id="3aed35f" data-element_type="container" data-settings="{"background_background":"classic"}"> </div> <div class="elementor-element elementor-element-cc14d04 e-con-full e-flex e-con e-child" data-id="cc14d04" data-element_type="container"> <div class="elementor-element elementor-element-b720128 elementor-widget elementor-widget-heading" data-id="b720128" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h5 class="elementor-heading-title elementor-size-default">How-To Guide</h5> </div> </div> <div class="elementor-element elementor-element-0200742 elementor-widget elementor-widget-heading" data-id="0200742" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h4 class="elementor-heading-title elementor-size-default">Mixing Bioreactors with Bottom Mounted Impellers</h4> </div> </div> <div class="elementor-element elementor-element-2f597ca elementor-widget elementor-widget-text-editor" data-id="2f597ca" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> Learn how to use M-Star CFD to predict the single fluid and multi-fluid mixing behavior of bioreactors across a variety of scales, fluid volumes, and impeller speeds. </div> </div> <div class="elementor-element elementor-element-0b96c52 elementor-widget elementor-widget-button" data-id="0b96c52" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a 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elementor-widget elementor-widget-heading" data-id="07ec836" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h5 class="elementor-heading-title elementor-size-default">Success Story</h5> </div> </div> <div class="elementor-element elementor-element-466ca97 elementor-widget elementor-widget-heading" data-id="466ca97" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h4 class="elementor-heading-title elementor-size-default">"A mechanistic approach for predicting mass transfer in bioreactors"</h4> </div> </div> <div class="elementor-element elementor-element-ad4d31d elementor-widget elementor-widget-text-editor" data-id="ad4d31d" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> Read how M-Star worked with Bristol-Myers Squibb to develop and validate physics-based models for predicting mass transfer in sparged bioreactors at multiple scales. </div> </div> <div class="elementor-element elementor-element-b097ecb elementor-widget elementor-widget-button" data-id="b097ecb" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="https://www.sciencedirect.com/science/article/pii/S0009250921001032?dgcid=rss_sd_all" target="_blank"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-icon"> <i aria-hidden="true" class="fas fa-angle-right"></i> </span> <span class="elementor-button-text">Read the paper</span> </span> </a> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-090063c e-con-full e-flex e-con e-child" data-id="090063c" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="elementor-element elementor-element-13aa58a e-con-full e-flex e-con e-child" data-id="13aa58a" data-element_type="container" data-settings="{"background_background":"classic"}"> </div> <div class="elementor-element elementor-element-22c38c7 e-con-full e-flex e-con e-child" data-id="22c38c7" data-element_type="container"> <div class="elementor-element elementor-element-86bb356 elementor-widget elementor-widget-heading" data-id="86bb356" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h5 class="elementor-heading-title elementor-size-default">Success Story</h5> </div> </div> <div class="elementor-element elementor-element-82aace4 elementor-widget elementor-widget-heading" data-id="82aace4" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h4 class="elementor-heading-title elementor-size-default">"Modeling mass transfer in stirred microbioreactors"</h4> </div> </div> <div class="elementor-element elementor-element-0e777e1 elementor-widget elementor-widget-text-editor" data-id="0e777e1" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> Pfizer works with M-Star to present a mechanistic in-silico approach for predicting mixing and mass transfer in a two-phase stirred tank bioreactor. </div> </div> <div class="elementor-element elementor-element-deaf76a elementor-widget elementor-widget-button" data-id="deaf76a" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="https://www.sciencedirect.com/science/article/pii/S0009250921007119" target="_blank"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-icon"> <i aria-hidden="true" class="fas fa-angle-right"></i> </span> <span class="elementor-button-text">Read the paper</span> </span> </a> </div> </div> </div> </div> </div> <div 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data-widget_type="heading.default"> <div class="elementor-widget-container"> <h4 class="elementor-heading-title elementor-size-default">Real-time CFD-Based Bioreactor Models with Integrated Process Control</h4> </div> </div> <div class="elementor-element elementor-element-be6ecef elementor-widget elementor-widget-text-editor" data-id="be6ecef" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> M-Star President John Thomas highlights the transformative role of digital twins in reactor modeling, emphasizing a physics-based modeling approach over traditional methods. </div> </div> <div class="elementor-element elementor-element-ac0e6bd elementor-widget elementor-widget-button" data-id="ac0e6bd" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="/resources/videos/webinars/real-time-cfd-based-bioreactor-models-with-integrated-process-control/"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-icon"> <i aria-hidden="true" class="fas fa-angle-right"></i> </span> <span class="elementor-button-text">Watch the webinar</span> </span> </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-3ead275 e-flex e-con-boxed e-con e-parent" data-id="3ead275" data-element_type="container"> <div class="e-con-inner"> <div class="elementor-element elementor-element-a3c7709 e-con-full e-flex e-con e-child" data-id="a3c7709" data-element_type="container"> <div class="elementor-element elementor-element-ce8f8de elementor-widget elementor-widget-template" data-id="ce8f8de" data-element_type="widget" data-widget_type="template.default"> <div class="elementor-widget-container"> <div class="elementor-template"> <div data-elementor-type="container" 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Open items with Enter or Space, close with Escape and navigate using the Arrow keys."> <div class="e-n-tabs-heading" role="tablist"> <button id="e-n-tab-title-14606752741" class="e-n-tab-title" aria-selected="true" data-tab-index="1" role="tab" tabindex="0" aria-controls="e-n-tab-content-14606752741" style="--n-tabs-title-order: 1;"> <span class="e-n-tab-title-text"> <img decoding="async" src="https://mstarcfd.com/wp-content/uploads/AbbVie_logo-1.svg" width="160px" height="auto"> </span> </button> <button id="e-n-tab-title-14606752742" class="e-n-tab-title" aria-selected="false" data-tab-index="2" role="tab" tabindex="-1" aria-controls="e-n-tab-content-14606752742" style="--n-tabs-title-order: 2;"> <span class="e-n-tab-title-text"> <img decoding="async" src="https://mstarcfd.com/wp-content/uploads/Bristol-Myers_Squibb_logo-1.svg" width="160px" height="auto"> </span> </button> <button id="e-n-tab-title-14606752743" class="e-n-tab-title" aria-selected="false" data-tab-index="3" 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data-settings="{"background_background":"classic"}"> <div class="elementor-element elementor-element-474873d3 e-flex e-con-boxed e-con e-child" data-id="474873d3" data-element_type="container"> <div class="e-con-inner"> <div class="elementor-element elementor-element-1c866853 elementor-widget elementor-widget-heading" data-id="1c866853" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Case Study</h2> </div> </div> <div class="elementor-element elementor-element-1b512917 elementor-widget elementor-widget-heading" data-id="1b512917" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">How AbbVie Built Digital Twins to Understand Miscible Fluid Blending</h3> </div> </div> <div class="elementor-element elementor-element-67e9f0cc elementor-widget elementor-widget-text-editor" data-id="67e9f0cc" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> With M-Star CFD software, AbbVie built accelerated digital twins of a physical mixing tank to predict real-time fluid mechanics with a fidelity that rivals experimental data. </div> </div> <div class="elementor-element elementor-element-f17922a elementor-widget elementor-widget-button" data-id="f17922a" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="https://mstarcfd.com/resources/case-study/how-abbvie-built-digital-twins-to-understand-miscible-fluid-blending/"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-icon"> <i aria-hidden="true" class="fas fa-angle-right"></i> </span> <span class="elementor-button-text">Learn more</span> </span> 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class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Case Study</h2> </div> </div> <div class="elementor-element elementor-element-5fab6f1b elementor-widget elementor-widget-heading" data-id="5fab6f1b" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">Bristol Myers Squibb Predicts Mass & Oxygen Transfer in Bioreactors </h3> </div> </div> <div class="elementor-element elementor-element-33ec2298 elementor-widget elementor-widget-text-editor" data-id="33ec2298" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> BMS used M-Star CFD to build time dependent, bubble-resolved, two-phase models to investigate the real-time blending, and mass and oxygen transfer in stirred tank bioreactors. </div> </div> <div class="elementor-element elementor-element-2cbca004 elementor-widget 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style="--n-tabs-title-order: 3;" class=" elementor-element elementor-element-1c4d8cce e-con-full e-flex e-con e-child" data-id="1c4d8cce" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="elementor-element elementor-element-40862ca5 e-flex e-con-boxed e-con e-child" data-id="40862ca5" data-element_type="container"> <div class="e-con-inner"> <div class="elementor-element elementor-element-5549c3bd elementor-widget elementor-widget-heading" data-id="5549c3bd" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Case Study</h2> </div> </div> <div class="elementor-element elementor-element-79c67350 elementor-widget elementor-widget-heading" data-id="79c67350" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">How Pfizer Leveraged Digital Twins to Create a Process Scale-Up Roadmap</h3> </div> </div> <div class="elementor-element elementor-element-400c8719 elementor-widget elementor-widget-text-editor" data-id="400c8719" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> Pfizer built digital twins with M-Star CFD to perform lab experiments in silico, accelerating the speed of manufacturing innovation and minimizing the scope of required supporting experimental studies. </div> </div> <div class="elementor-element elementor-element-57c0485a elementor-widget elementor-widget-button" data-id="57c0485a" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="https://mstarcfd.com/resources/case-study/how-pfizer-leveraged-digital-twins-to-create-a-process-scale-up-roadmap/"> <span 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class="elementor-element elementor-element-26b9dc1c elementor-widget elementor-widget-heading" data-id="26b9dc1c" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Publication</h2> </div> </div> <div class="elementor-element elementor-element-6bced80c elementor-widget elementor-widget-heading" data-id="6bced80c" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">Validating Lattice Boltzmann LES for Biopharma Equipment Characterization </h3> </div> </div> <div class="elementor-element elementor-element-74439ac3 elementor-widget elementor-widget-text-editor" data-id="74439ac3" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> Boehringer Ingelheim and the Institute of Multiphase Flows use M-Star CFD to apply transient LB LES to a 3L bioreactor system and compare results to a steady RANS simulation. </div> </div> <div class="elementor-element elementor-element-5b9f434b elementor-widget elementor-widget-button" data-id="5b9f434b" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="https://mstarcfd.com/resources/guide/validating-lattice-boltzmann-les-for-biopharma-equipment-characterization/"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-icon"> <i aria-hidden="true" class="fas fa-angle-right"></i> </span> <span class="elementor-button-text">Learn more</span> </span> </a> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-3ed65c12 e-flex e-con-boxed e-con e-child" data-id="3ed65c12" data-element_type="container" data-settings="{"background_background":"classic"}"> <div 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