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data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h1 class="elementor-heading-title elementor-size-default">Peer Reviewed Validation</h1> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-50060be e-flex e-con-boxed e-con e-parent" data-id="50060be" data-element_type="container"> <div class="e-con-inner"> <div class="elementor-element elementor-element-c7d41a9 e-flex e-con-boxed e-con e-child" data-id="c7d41a9" data-element_type="container"> <div class="e-con-inner"> <div class="elementor-element elementor-element-e37f87f e-con-full e-flex e-con e-child" data-id="e37f87f" data-element_type="container"> <div class="elementor-element elementor-element-315e180 e-con-full e-flex e-con e-child" data-id="315e180" data-element_type="container"> <div class="elementor-element elementor-element-f5f9704 elementor-widget elementor-widget-image" data-id="f5f9704" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" width="150" height="200" src="https://mstarcfd.com/wp-content/uploads/1-s2.0-s0378517323x00209-cov200h.gif" class="attachment-large size-large wp-image-3196" alt="" /> </div> </div> </div> <div class="elementor-element elementor-element-dfbe0e3 e-con-full e-flex e-con e-child" data-id="dfbe0e3" data-element_type="container"> <div class="elementor-element elementor-element-989cb36 elementor-widget elementor-widget-text-editor" data-id="989cb36" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><span style="letter-spacing: -0.3px; line-height: 1.3em;"><a href="https://www.sciencedirect.com/science/article/abs/pii/S0378517323011742?casa_token=dXzfrIs19q0AAAAA:IFTdA_G0DKlIH8Z86Z10kWJS_0wE2ZI30dY6RZUHlzS0Q50D6zmFMDaMYhmMMfe_qiLqaWFy">Investigating the Hydrodynamics of Intravenous Drug Infusions</a></span><strong><br /></strong><em style="font-size: 16px; font-weight: 400;">International Journal of Pharmaceutics (February 2024)</em><em style="text-align: var(--text-align); color: #333333; font-family: var( --e-global-typography-text-font-family ), 'Public Sans', 'Arial', Sans-serif; font-size: 1rem; font-weight: var( --e-global-typography-text-font-weight );"><br /></em><span style="font-size: 16px; font-weight: 400;">MD Shujan Ali, Steven Castleberry</span><span style="font-size: 16px; font-weight: 400;">聽</span></p><p><span style="font-size: 16px; font-weight: 400;">In this study, Genentech employs Large-Eddy Simulation (LES) turbulence modeling with M-Star CFD to simulate the flow and mixing of infusions in the bloodstream, aiming to improve the understanding of these adverse events. The results, which closely match benchtop tests, explore how varying fluid dynamics, needle orientation, and needle positioning affect infusion mixing, providing insights for developing safer intravenous formulations.</span></p> </div> </div> </div> </div> <div class="elementor-element elementor-element-fa7e267 e-con-full e-flex e-con e-child" data-id="fa7e267" data-element_type="container"> <div class="elementor-element elementor-element-c95411d e-con-full e-flex e-con e-child" data-id="c95411d" data-element_type="container"> <div class="elementor-element elementor-element-a085592 elementor-widget elementor-widget-image" data-id="a085592" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img fetchpriority="high" decoding="async" width="576" height="768" src="https://mstarcfd.com/wp-content/uploads/X00092509.jpg" class="attachment-large size-large wp-image-3210" alt="" srcset="https://mstarcfd.com/wp-content/uploads/X00092509.jpg 576w, https://mstarcfd.com/wp-content/uploads/X00092509-225x300.jpg 225w" sizes="(max-width: 576px) 100vw, 576px" /> </div> </div> </div> <div class="elementor-element elementor-element-4c283a4 e-con-full e-flex e-con e-child" data-id="4c283a4" data-element_type="container"> <div class="elementor-element elementor-element-50ade97 elementor-widget elementor-widget-text-editor" data-id="50ade97" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://www.sciencedirect.com/science/article/abs/pii/S0009250924012442?via%3Dihub">A numerical study on the mixing time prediction of miscible liquids with high viscosity ratios in turbulently stirred vessels </a><br></strong><em style="text-align: var(--text-align); color: #333333; font-family: var( --e-global-typography-text-font-family ), 'Public Sans', 'Arial', Sans-serif; font-size: 1rem; font-weight: var( --e-global-typography-text-font-weight );">Chemical Engineering Science (February 2025)<br></em><span style="font-size: 16px; font-weight: 400;">Soroch Mirfasihi, Wrichik Basu, Philip Martin, Adam Kowalski, Claudio P. Fonte, Amir Keshmiri </span></p> <p><span style="font-size: 16px; font-weight: 400; font-family: var( --e-global-typography-secondary-font-family ), 'Public Sans', 'Arial', Sans-serif; text-align: var(--text-align);">Results from this joint study by the University of Manchester and Unilever show that GPU-based M-Star CFD outperformed CPU-based StarCCM+ in both speed and efficiency. </span><span style="font-size: 16px; font-weight: 400;">Mixing processes are vital for ensuring product quality in industries like food and pharmaceuticals, especially when dealing with high-viscosity fluids. This study compares two CFD methodologies鈥擱ANS-FVM and LB-LES solvers鈥攊n predicting blending times for miscible liquids with contrasting viscosities, validated using experimental ERT data. </span></p> </div> </div> </div> </div> <div class="elementor-element elementor-element-1de38b9 e-con-full e-flex e-con e-child" data-id="1de38b9" data-element_type="container"> <div class="elementor-element elementor-element-24a98cf e-con-full e-flex e-con e-child" data-id="24a98cf" data-element_type="container"> <div class="elementor-element elementor-element-c88083e elementor-widget elementor-widget-image" data-id="c88083e" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" width="148" height="200" src="https://mstarcfd.com/wp-content/uploads/CEJAdvances.gif" class="attachment-large size-large wp-image-3206" alt="" /> </div> </div> </div> <div class="elementor-element elementor-element-c1614a5 e-con-full e-flex e-con e-child" data-id="c1614a5" data-element_type="container"> <div class="elementor-element elementor-element-855f111 elementor-widget elementor-widget-text-editor" data-id="855f111" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><span style="text-align: var(--text-align); letter-spacing: -0.3px;"><span style="color: #36ae8a;"><a href="https://www.sciencedirect.com/science/article/pii/S1385894724072176">Trajectory-based breakup modelling for dense bubbly flows</a>聽</span></span><strong><br /></strong><em style="text-align: var(--text-align); color: #333333; font-family: var( --e-global-typography-text-font-family ), 'Public Sans', 'Arial', Sans-serif; font-size: 1rem; font-weight: var( --e-global-typography-text-font-weight );">Chemical Engineering Journal (November 2024)<br /></em><span style="font-size: 16px; font-weight: 400;">Christian Weiland, Alexandra von Kameke, Michael Schl眉ter聽</span></p><p><span style="text-align: var(--text-align); font-size: 16px; font-weight: 400;">The Hamburg University of Technology and of Applied Sciences employ M-Star CFD to simulate the breakup of gaseous bubbles in a liquid phase using a new Kelvin鈥揤oigt-based spring鈥揹amper model derived from Lagrangian analysis. The model tracks individual bubbles through the flow, incorporating their history, and enables cost-efficient simulations across scales from laboratory vessels to large industrial reactors. Results, validated against optical experimental data from an aerated stirred tank reactor, demonstrate the model’s effectiveness in capturing bubble dynamics under varying stirrer frequencies.</span><span style="font-family: var( --e-global-typography-secondary-font-family ), 'Public Sans', 'Arial', Sans-serif; font-size: 16px; font-weight: 400; text-align: var(--text-align);">聽</span></p> </div> </div> </div> </div> <div class="elementor-element elementor-element-379105e e-con-full e-flex e-con e-child" data-id="379105e" data-element_type="container"> <div class="elementor-element elementor-element-64e61ba e-con-full e-flex e-con e-child" data-id="64e61ba" data-element_type="container"> <div class="elementor-element elementor-element-83a2eba elementor-widget elementor-widget-image" data-id="83a2eba" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="576" height="768" src="https://mstarcfd.com/wp-content/uploads/x1369703x.jpg" class="attachment-large size-large wp-image-3197" alt="" srcset="https://mstarcfd.com/wp-content/uploads/x1369703x.jpg 576w, https://mstarcfd.com/wp-content/uploads/x1369703x-225x300.jpg 225w" sizes="auto, (max-width: 576px) 100vw, 576px" /> </div> </div> </div> <div class="elementor-element elementor-element-f4a0fe2 e-con-full e-flex e-con e-child" data-id="f4a0fe2" data-element_type="container"> <div class="elementor-element elementor-element-32b75e8 elementor-widget elementor-widget-text-editor" data-id="32b75e8" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://www.sciencedirect.com/science/article/abs/pii/S1369703X24001244?fr=RR-2&ref=pdf_download&rr=88431af3ca6b32ad">Study of hydrodynamic stress in ce<em>ll culture bioreactors via lattice-Boltzmann CFD simulations supported by micro-probe shear stress method</em></a></strong><br /><em>Biochemical Engineering Journal (May 2024)</em><br />Ond艡ej聽艩rom, Miroslav聽艩o贸拧, Maike聽Kuschel, Thomas聽Wucherpfennig, J眉rgen聽Fitschen, Michael聽Schl眉ter</p><p>The University of Chemistry and Technology Prague, Boehringer Ingelheim Pharma, and the Hamburg University of Technology explore the application of shear-sensitive micro-probes to measure maximum hydrodynamic stress in mammalian cell cultivation across various bioreactor scales, from laboratory to industrial production. The study details the successful validation of experimental data with comprehensive M-Star CFD simulations, specifically using the Lattice-Boltzmann large eddy simulation method.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-b8ad96b e-con-full e-flex e-con e-child" data-id="b8ad96b" data-element_type="container"> <div class="elementor-element elementor-element-fb231a3 e-con-full e-flex e-con e-child" data-id="fb231a3" data-element_type="container"> <div class="elementor-element elementor-element-7e13607 elementor-widget elementor-widget-image" data-id="7e13607" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="150" height="200" src="https://mstarcfd.com/wp-content/uploads/1-s2.0-s0168165624x00085-cov200h.gif" class="attachment-large size-large wp-image-3199" alt="" /> </div> </div> </div> <div class="elementor-element elementor-element-1a4bfd3 e-con-full e-flex e-con e-child" data-id="1a4bfd3" data-element_type="container"> <div class="elementor-element elementor-element-9c2883f elementor-widget elementor-widget-text-editor" data-id="9c2883f" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://www.sciencedirect.com/science/article/pii/S0168165624001123?dgcid=coauthor">An聽<em>in-silico</em>聽analysis of hydrodynamics and gas mass transfer characteristics in scale-down models for mammalian cell cultures</a></strong><br /><em>Journal of Biotechnology (June 2024)</em><br />Alaina Anand, Madelynn McCahill, John Thomas, Aishwarya Sood, Jonathan Kinross, Aparajita Dasgupta, Aravindan Rajendran</p> <p>Pfizer joins up with M-Star to investigate bioprocess scale-up challenges, focusing on factors like geometric variability and nutrient gradients. Using advanced computational fluid dynamics, it characterizes the Ambr庐 250 bioreactor, revealing insights into agitation dynamics and mass transfer. The findings validate computational fluid dynamics for understanding bioreactor hydrodynamics and emphasize the importance of considering free-surface transfer mechanics for accurate scale-down model qualification in mammalian bioprocess development.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-dd846b3 e-con-full e-flex e-con e-child" data-id="dd846b3" data-element_type="container"> <div class="elementor-element elementor-element-dce0490 e-con-full e-flex e-con e-child" data-id="dce0490" data-element_type="container"> <div class="elementor-element elementor-element-90bf892 elementor-widget elementor-widget-image" data-id="90bf892" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="114" height="150" src="https://mstarcfd.com/wp-content/uploads/bit.webp" class="attachment-large size-large wp-image-3198" alt="" /> </div> </div> </div> <div class="elementor-element elementor-element-bf4debe e-con-full e-flex e-con e-child" data-id="bf4debe" data-element_type="container"> <div class="elementor-element elementor-element-5aa86ae elementor-widget elementor-widget-text-editor" data-id="5aa86ae" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/bit.28727">Computational fluid dynamics based digital twins of fixed bed bioreactors validate scaling principles for recombinant adeno-associated virus gene therapy manufacturing</a></strong><br /><em>Biotechnology and Bioengineering (May 2024)</em><br />Michael Hill,聽Colten White,聽Shaoying Wang,聽John Thomas,聽Brian DeVincentis,聽Nripen Singh聽</p><p>Passage Bio and M-Star explore gene therapy鈥檚 potential using recombinant adeno-associated virus (rAAV) and highlights gaps in manufacturing processes. Utilizing computational fluid dynamics, the study validates operating conditions for a predictive iCELLis庐 500 scale-down model, addressing challenges in achieving consistent agitation rates and oxygen transfer across scales. Experimental validation confirms the efficacy of the novel scale-down model, offering insights crucial for optimizing rAAV manufacturing using fixed bed bioreactors.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-f2b732e e-con-full e-flex e-con e-child" data-id="f2b732e" data-element_type="container"> <div class="elementor-element elementor-element-e6a0991 e-con-full e-flex e-con e-child" data-id="e6a0991" data-element_type="container"> <div class="elementor-element elementor-element-30a2904 elementor-widget elementor-widget-image" data-id="30a2904" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="150" height="200" src="https://mstarcfd.com/wp-content/uploads/1-s2.0-S0017931023X00179-cov200h.gif" class="attachment-large size-large wp-image-3200" alt="" /> </div> </div> </div> <div class="elementor-element elementor-element-05664ba e-con-full e-flex e-con e-child" data-id="05664ba" data-element_type="container"> <div class="elementor-element elementor-element-a281d32 elementor-widget elementor-widget-text-editor" data-id="a281d32" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://www.sciencedirect.com/science/article/abs/pii/S0017931023011341#:~:text=A%20generalized%20approach%20for%20predicting,the%20near%2Dwall%20boundary%20layer.">A general approach for predicting convective heat transfer coefficients in turbulent systems聽</a></strong><br /><em>International Journal of Heat and Mass Transfer (March 2024)</em><br />John A. Thomas, Brian聽DeVincentis,聽Eric Janz, Ben Turner</p><p>M-Star presents an approach for predicting turbulent convective聽heat transfer coefficients聽using聽large eddy simulation.聽This is applied to agitated tanks,聽pipe flow聽systems, cylinders in crossflow, and tube bundles鈥攁ll validating the generality and reliability of the theoretical model against expectations from experimentally derived empirical design correlations.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-b4139e2 e-con-full e-flex e-con e-child" data-id="b4139e2" data-element_type="container"> <div class="elementor-element elementor-element-c19aa9a e-con-full e-flex e-con e-child" data-id="c19aa9a" data-element_type="container"> <div class="elementor-element elementor-element-a9157db elementor-widget elementor-widget-image" data-id="a9157db" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="114" height="150" src="https://mstarcfd.com/wp-content/uploads/bit-copy.jpg" class="attachment-large size-large wp-image-3201" alt="" /> </div> </div> </div> <div class="elementor-element elementor-element-5e634e6 e-con-full e-flex e-con e-child" data-id="5e634e6" data-element_type="container"> <div class="elementor-element elementor-element-4f9d617 elementor-widget elementor-widget-text-editor" data-id="4f9d617" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://onlinelibrary.wiley.com/doi/10.1002/bit.28598" target="_blank" rel="noreferrer noopener">CFD-based bioreactor model with proportional-integral-derivative controller functionality for dissolved oxygen and pH</a></strong><br /><em>Biotechnology and Bioengineering (October 2023)</em><br />Christopher L. Oliveira, Zoe Pace, John A. Thomas, Brian DeVincentis, Chadakarn Sirasitthichoke, Susan Egan, Johnchan Lee</p><p>M-Star teams up with Bristol Myers Squibb to present a physics-based model with embedded PID controller logic for predicting cell culture fluid properties inside a stirred tank bioreactor. Agreement between the model prediction and measured bioreactor data is realized, and simulation runtimes are shown to be suitable for industrial research and design timescales.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-6e8c70f e-con-full e-flex e-con e-child" data-id="6e8c70f" data-element_type="container"> <div class="elementor-element elementor-element-2110360 e-con-full e-flex e-con e-child" data-id="2110360" data-element_type="container"> <div class="elementor-element elementor-element-a89949c elementor-widget elementor-widget-image" data-id="a89949c" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="576" height="768" src="https://mstarcfd.com/wp-content/uploads/X08981221.jpg" class="attachment-large size-large wp-image-3202" alt="" srcset="https://mstarcfd.com/wp-content/uploads/X08981221.jpg 576w, https://mstarcfd.com/wp-content/uploads/X08981221-225x300.jpg 225w" sizes="auto, (max-width: 576px) 100vw, 576px" /> </div> </div> </div> <div class="elementor-element elementor-element-660a45d e-con-full e-flex e-con e-child" data-id="660a45d" data-element_type="container"> <div class="elementor-element elementor-element-101be5b elementor-widget elementor-widget-text-editor" data-id="101be5b" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://www.sciencedirect.com/science/article/pii/S0898122123002365?dgcid=coauthor" target="_blank" rel="noreferrer noopener">Application of flux limiters to passive scalar advection for the lattice Boltzmann method</a></strong><br /><em>Computers & Mathematics with Applications (August 2023)</em><br />Brian聽DeVincentis,聽John聽Thomas</p><p>Given its wide application, the accurate and efficient solution to the advection-diffusion equation is of great interest.聽Here, M-Star CFD presents a new scalar advection algorithm for the lattice Boltzmann method鈥攖he flux limiter lattice advection (FLLA). The algorithm is designed to be conservative and have low memory requirements.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-40f4cc6 e-con-full e-flex e-con e-child" data-id="40f4cc6" data-element_type="container"> <div class="elementor-element elementor-element-5ed5ac1 e-con-full e-flex e-con e-child" data-id="5ed5ac1" data-element_type="container"> <div class="elementor-element elementor-element-e71ebdf elementor-widget elementor-widget-image" data-id="e71ebdf" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="542" height="768" src="https://mstarcfd.com/wp-content/uploads/CHRD.jpeg" class="attachment-large size-large wp-image-3203" alt="" srcset="https://mstarcfd.com/wp-content/uploads/CHRD.jpeg 542w, https://mstarcfd.com/wp-content/uploads/CHRD-212x300.jpeg 212w" sizes="auto, (max-width: 542px) 100vw, 542px" /> </div> </div> </div> <div class="elementor-element elementor-element-2548a93 e-con-full e-flex e-con e-child" data-id="2548a93" data-element_type="container"> <div class="elementor-element elementor-element-c08f6c0 elementor-widget elementor-widget-text-editor" data-id="c08f6c0" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><a href="https://www.sciencedirect.com/science/article/abs/pii/S026387622300299X?via%3Dihub" target="_blank" rel="noreferrer noopener"><strong>Experimental Determination and Computational Prediction of Blend Time in the USP Dissolution Testing Apparatus 1</strong></a><br /><em>Chemical Engineering Research and Design (May 2023)</em><br />Justin聽Pace,聽Chadakarn聽Sirasitthichoke,聽Piero M.聽Armenante</p><p>New Jersey Institute of Technology uses M-Star CFD to obtain the blend time for different operating conditions. Their computationally predicted and experimental blend times were found to be in agreement. They subsequently developed an empirical correlation for blend time which will help practitioners determine the exemplification of representative samples.聽</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-c867dc5 e-con-full e-flex e-con e-child" data-id="c867dc5" data-element_type="container"> <div class="elementor-element elementor-element-fb703be e-con-full e-flex e-con e-child" data-id="fb703be" data-element_type="container"> <div class="elementor-element elementor-element-86535f6 elementor-widget elementor-widget-image" data-id="86535f6" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="595" height="782" src="https://mstarcfd.com/wp-content/uploads/btpr.v39.1.cover_.jpg" class="attachment-large size-large wp-image-3204" alt="" srcset="https://mstarcfd.com/wp-content/uploads/btpr.v39.1.cover_.jpg 595w, https://mstarcfd.com/wp-content/uploads/btpr.v39.1.cover_-228x300.jpg 228w" sizes="auto, (max-width: 595px) 100vw, 595px" /> </div> </div> </div> <div class="elementor-element elementor-element-6b54502 e-con-full e-flex e-con e-child" data-id="6b54502" data-element_type="container"> <div class="elementor-element elementor-element-58c16f6 elementor-widget elementor-widget-text-editor" data-id="58c16f6" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://aiche.onlinelibrary.wiley.com/doi/10.1002/btpr.3330" target="_blank" rel="noreferrer noopener">Experimental and computational characterization of mass transfer in high turndown bioreactors</a></strong><br /><em>Biotechnology Progress (February 2023)</em><br />Evan M. Schlaich,聽John A. Thomas,聽Lakshmi Kandari,聽Gabi Tremml,聽Anurag Khetan</p><p>Single-use bioreactors are extensively used for the clinical and commercial production of biologics.聽In this work, Bristol Myers Squibb works with M-Star to present a systematic investigation into free surface mass transfer and cell growth in high turndown single-use bioreactors. The results suggest an approach which potentially simplifies preculture operations.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-a21e312 e-con-full e-flex e-con e-child" data-id="a21e312" data-element_type="container"> <div class="elementor-element elementor-element-1883a7c e-con-full e-flex e-con e-child" data-id="1883a7c" data-element_type="container"> <div class="elementor-element elementor-element-45d147f elementor-widget elementor-widget-image" data-id="45d147f" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="460" height="652" src="https://mstarcfd.com/wp-content/uploads/Screenshot-2023-02-05-at-1.13.07-PM.png" class="attachment-large size-large wp-image-3205" alt="" srcset="https://mstarcfd.com/wp-content/uploads/Screenshot-2023-02-05-at-1.13.07-PM.png 460w, https://mstarcfd.com/wp-content/uploads/Screenshot-2023-02-05-at-1.13.07-PM-212x300.png 212w" sizes="auto, (max-width: 460px) 100vw, 460px" /> </div> </div> </div> <div class="elementor-element elementor-element-68a1ce6 e-con-full e-flex e-con e-child" data-id="68a1ce6" data-element_type="container"> <div class="elementor-element elementor-element-ef4fa78 elementor-widget elementor-widget-text-editor" data-id="ef4fa78" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://www.frontiersin.org/articles/10.3389/fceng.2023.1076509/full" target="_blank" rel="noreferrer noopener">CFD supported scale up of perfusion bioreactors in biopharma</a></strong><br /><em>Frontiers in Chemical Engineering (January 2023)</em><br />Maike Kuschel, Johannes Wutz, Mustafa Salli, Dominique Monteil,聽Thomas Wucherpfennig</p><p>M-Star Center Europe works with Boehringer Ingelheim to demonstrate how computational fluid dynamic models can be used for rational process design of intensified production processes in the biopharmaceutical industry. Computational fluid dynamics can be used to identify short circuit flows, assess mixing efficiencies, and adapt the perfusion setup.聽</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-a88e6e5 e-con-full e-flex e-con e-child" data-id="a88e6e5" data-element_type="container"> <div class="elementor-element elementor-element-c068df0 e-con-full e-flex e-con e-child" data-id="c068df0" data-element_type="container"> <div class="elementor-element elementor-element-f96f2b2 elementor-widget elementor-widget-image" data-id="f96f2b2" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" width="148" height="200" src="https://mstarcfd.com/wp-content/uploads/CEJAdvances.gif" class="attachment-large size-large wp-image-3206" alt="" /> </div> </div> </div> <div class="elementor-element elementor-element-6966b2a e-con-full e-flex e-con e-child" data-id="6966b2a" data-element_type="container"> <div class="elementor-element elementor-element-d8de549 elementor-widget elementor-widget-text-editor" data-id="d8de549" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://www.sciencedirect.com/science/article/pii/S2666821123000066?via%3Dihub" target="_blank" rel="noreferrer noopener">Computational study of three-dimensional Lagrangian transport and mixing in a stirred tank reactor</a></strong><br /><em>Chemical Engineering Journal Advances (January 2023)</em><br />Christian Weiland, Eike Steuwe, J眉rgen Fitschen, Marko Hoffmann, Michael Schl眉ter, Kathrin Padberg-Gehle, Alexandra von Kameke</p><p>The detection of compartments and dead zones as well as the estimation of the mixing efficiency in stirred tanks are of vital interest for a variety of biochemical and chemical processes.聽Here, researchers from Hamburg University of Technology, Hamburg University of Applied Sciences, and Leuphana University L眉neburg use M-Star CFD to numerically derive time-dependent 3D fluid velocity fields of a stirred tank reactor using the Lattice Boltzmann Method.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-6b79ddb e-con-full e-flex e-con e-child" data-id="6b79ddb" data-element_type="container"> <div class="elementor-element elementor-element-8c2fb67 e-con-full e-flex e-con e-child" data-id="8c2fb67" data-element_type="container"> <div class="elementor-element elementor-element-0d137bd elementor-widget elementor-widget-image" data-id="0d137bd" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="149" height="200" src="https://mstarcfd.com/wp-content/uploads/chemengsci12-22.png.gif" class="attachment-large size-large wp-image-3207" alt="" /> </div> </div> </div> <div class="elementor-element elementor-element-f63beae e-con-full e-flex e-con e-child" data-id="f63beae" data-element_type="container"> <div class="elementor-element elementor-element-fac6133 elementor-widget elementor-widget-text-editor" data-id="fac6133" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://www.sciencedirect.com/science/article/pii/S0009250922007679" target="_blank" rel="noreferrer noopener">Predicting gas-liquid mass transfer rates in reactors using a bubble parcel model</a></strong><br /><em>Chemical Engineering Sciences (December 2022)</em><br />John A. Thomas, Brian DeVincentis, Navraj Hanspal, Richard O. Kehn</p><p>Understanding scale-up mechanisms is critical for reducing performance losses in industrial applications. In this article, M-Star works with Corteva Agriscience and SPX FLOW to present a transient large eddy simulation (LES) modeling approach for simulating the interlinked physics describing free surface hydrodynamics, multiphase mixing, reaction kinetics, and mass transport in bioreactor systems.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-68f3bc8 e-con-full e-flex e-con e-child" data-id="68f3bc8" data-element_type="container"> <div class="elementor-element elementor-element-b587764 e-con-full e-flex e-con e-child" data-id="b587764" data-element_type="container"> <div class="elementor-element elementor-element-384c03c elementor-widget elementor-widget-image" data-id="384c03c" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="759" height="1000" src="https://mstarcfd.com/wp-content/uploads/elsc.webp" class="attachment-large size-large wp-image-3208" alt="" srcset="https://mstarcfd.com/wp-content/uploads/elsc.webp 759w, https://mstarcfd.com/wp-content/uploads/elsc-228x300.webp 228w" sizes="auto, (max-width: 759px) 100vw, 759px" /> </div> </div> </div> <div class="elementor-element elementor-element-65e55fd e-con-full e-flex e-con e-child" data-id="65e55fd" data-element_type="container"> <div class="elementor-element elementor-element-a483e7f elementor-widget elementor-widget-text-editor" data-id="a483e7f" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://onlinelibrary.wiley.com/doi/10.1002/elsc.202200020" target="_blank" rel="noreferrer noopener">Modeling multiphase fluid flow, mass transfer, and chemical reactions in bioreactors using large-eddy simulation</a></strong><br /><em>Engineering in Life Sciences (November 2022)</em><br />Navraj Hanspal,聽Brian DeVincentis,聽John A. Thomas</p><p>Due to increased demand worldwide, the number and scale of industrial bioprocesses continues to expand at a rapid rate. Understanding scale-up mechanisms for reducing performance losses is critical for successful industrial applications. In this work, Corteva Agriscience works with M-Star to present a large-eddy-simulation鈥揵ased approach to simulating a bioreactor system.聽It is shown that the presence of reactions can result in a non-uniform spatially varying species concentration field, the magnitude and extent of which is directly related to the reaction rates and the underlying variations in the local volumetric mass transfer coefficient.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-2776b3c e-con-full e-flex e-con e-child" data-id="2776b3c" data-element_type="container"> <div class="elementor-element elementor-element-d51e0ea e-con-full e-flex e-con e-child" data-id="d51e0ea" data-element_type="container"> <div class="elementor-element elementor-element-38feed9 elementor-widget elementor-widget-image" data-id="38feed9" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="761" height="1000" src="https://mstarcfd.com/wp-content/uploads/bit.v119.11.cover_.jpg" class="attachment-large size-large wp-image-3209" alt="" srcset="https://mstarcfd.com/wp-content/uploads/bit.v119.11.cover_.jpg 761w, https://mstarcfd.com/wp-content/uploads/bit.v119.11.cover_-228x300.jpg 228w" sizes="auto, (max-width: 761px) 100vw, 761px" /> </div> </div> </div> <div class="elementor-element elementor-element-4c978b4 e-con-full e-flex e-con e-child" data-id="4c978b4" data-element_type="container"> <div class="elementor-element elementor-element-0992e6f elementor-widget elementor-widget-text-editor" data-id="0992e6f" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://onlinelibrary.wiley.com/doi/10.1002/bit.28264" target="_blank" rel="noreferrer noopener">Computational prediction of blend time in a large-scale viral inactivation process for monoclonal antibodies biomanufacturing</a></strong><br /><em>Biotechnology and Bioengineering (October 2022)</em><br />Chadakarn Sirasitthichoke, Duc Hoang, Poonam Phalak, Piero M. Armenante, Barak I. Barnoon, Ishaan Shandil</p><p>M-Star, together with Bristol Myers Squibb, New Jersey Institute of Technology, and University of Massachusetts Lowell, used a CFD model based on the Lattice Boltzmann method (LBM) to predict the blend time to homogenize a Triton X-100鈥塻olution added during a typical full-scale commercial VI process. The results obtained in this study were used to support actual production at the biomanufacturing site.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-caf5791 e-con-full e-flex e-con e-child" data-id="caf5791" data-element_type="container"> <div class="elementor-element elementor-element-dc5f843 e-con-full e-flex e-con e-child" data-id="dc5f843" data-element_type="container"> <div class="elementor-element elementor-element-35b71a4 elementor-widget elementor-widget-image" data-id="35b71a4" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img fetchpriority="high" decoding="async" width="576" height="768" src="https://mstarcfd.com/wp-content/uploads/X00092509.jpg" class="attachment-large size-large wp-image-3210" alt="" srcset="https://mstarcfd.com/wp-content/uploads/X00092509.jpg 576w, https://mstarcfd.com/wp-content/uploads/X00092509-225x300.jpg 225w" sizes="(max-width: 576px) 100vw, 576px" /> </div> </div> </div> <div class="elementor-element elementor-element-0826ffc e-con-full e-flex e-con e-child" data-id="0826ffc" data-element_type="container"> <div class="elementor-element elementor-element-2ff88e2 elementor-widget elementor-widget-text-editor" data-id="2ff88e2" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://www.sciencedirect.com/science/article/pii/S0009250922007680?utm_campaign=STMJ_AUTH_SERV_PUBLISHED&utm_medium=email&utm_acid=139642284&SIS_ID=&dgcid=STMJ_AUTH_SERV_PUBLISHED&CMX_ID=&utm_in=DM307246&utm_source=AC_" target="_blank" rel="noreferrer noopener">Blending and Cavern Formation within Non-Newtonian Fluids in Stirred Tanks: Application to Nuclear Waste Fluid Processing</a></strong><br /><em>Chemical Engineering Science (October 2022)</em><br />Sean Noble, Michael R. Poirier, John A. Thomas</p><p>M-Star collaborates with the Savannah River National Laboratory to predict the time-accurate fluid flow and mixing properties of non-Newtonian fluids. Across the range of fluids and systems, the simulations required no reparameterization or retuning between scenarios. This generality allowed them to model a nuclear waste processing unit operation.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-a0c8930 e-con-full e-flex e-con e-child" data-id="a0c8930" data-element_type="container"> <div class="elementor-element elementor-element-9db82a2 e-con-full e-flex e-con e-child" data-id="9db82a2" data-element_type="container"> <div class="elementor-element elementor-element-1c15ce4 elementor-widget elementor-widget-image" data-id="1c15ce4" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="149" height="200" src="https://mstarcfd.com/wp-content/uploads/1-s2.0-S0009250922X00067-cov200h.gif" class="attachment-large size-large wp-image-3211" alt="" /> </div> </div> </div> <div class="elementor-element elementor-element-5bb9a9b e-con-full e-flex e-con e-child" data-id="5bb9a9b" data-element_type="container"> <div class="elementor-element elementor-element-7859187 elementor-widget elementor-widget-text-editor" data-id="7859187" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://www.sciencedirect.com/science/article/pii/S0009250922002354?via%3Dihub#!" target="_blank" rel="noreferrer noopener">Modeling gas release from a Bingham plastic slurry and deconvoluting measured data</a></strong><br /><em>Chemical Engineering Science (June 2022)</em><br />Michael R. Poirier, John A. Thomas, John M. Pareizs</p><p>M-Star works with the US Department of Energy performing Lattice Boltzmann computational fluid dynamics simulations to evaluate the impact of yield stress, impeller speed, and bubble size on the release of retained gas from a Bingham plastic slurry.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-a3b21b0 e-con-full e-flex e-con e-child" data-id="a3b21b0" data-element_type="container"> <div class="elementor-element elementor-element-ce1ae22 e-con-full e-flex e-con e-child" data-id="ce1ae22" data-element_type="container"> <div class="elementor-element elementor-element-ebc8170 elementor-widget elementor-widget-image" data-id="ebc8170" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="200" height="266" src="https://mstarcfd.com/wp-content/uploads/showCoverImage-1.webp" class="attachment-large size-large wp-image-3212" alt="" /> </div> </div> </div> <div class="elementor-element elementor-element-1fed4c7 e-con-full e-flex e-con e-child" data-id="1fed4c7" data-element_type="container"> <div class="elementor-element elementor-element-9f7560d elementor-widget elementor-widget-text-editor" data-id="9f7560d" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><a href="https://www.tandfonline.com/doi/full/10.1080/00986445.2022.2084392" target="_blank" rel="noreferrer noopener"><strong>Modeling free surface gas transfer in agitated lab-scale bioreactors</strong></a><br /><em>Chemical Engineering Communications (June 2022)</em><br />John A. Thomas, Anisur Rahman, Johannes Wutz, Ying Wang, Brian DeVincentis, Brendan McGuire, Lei Cao</p><p>In this study, AbbVie works with M-Star to find that the free surface mass transfer rate in lab-scale systems is consistent with empirical relationships regardless of the mechanical action driving motion. Also, the computational approach is shown to be practical within the context of industrial analysis and design timescales.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-d221d8a e-con-full e-flex e-con e-child" data-id="d221d8a" data-element_type="container"> <div class="elementor-element elementor-element-f88dab6 e-con-full e-flex e-con e-child" data-id="f88dab6" data-element_type="container"> <div class="elementor-element elementor-element-e0283b9 elementor-widget elementor-widget-image" data-id="e0283b9" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="759" height="1000" src="https://mstarcfd.com/wp-content/uploads/elsc-1.webp" class="attachment-large size-large wp-image-3213" alt="" srcset="https://mstarcfd.com/wp-content/uploads/elsc-1.webp 759w, https://mstarcfd.com/wp-content/uploads/elsc-1-228x300.webp 228w" sizes="auto, (max-width: 759px) 100vw, 759px" /> </div> </div> </div> <div class="elementor-element elementor-element-3ea7564 e-con-full e-flex e-con e-child" data-id="3ea7564" data-element_type="container"> <div class="elementor-element elementor-element-23ba9bf elementor-widget elementor-widget-text-editor" data-id="23ba9bf" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://onlinelibrary.wiley.com/doi/full/10.1002/elsc.202100159" target="_blank" rel="noreferrer noopener">An analysis of organism lifelines in an industrial bioreactor using Lattice-Boltzmann CFD</a></strong><br /><em>Engineering in Life Sciences (March 2022)</em><br />Cees Haringa</p><p>In this work by the Delft University of Technology, the performance of LB-LES in resolving substrate gradients in large-scale bioreactors is explored, combined with the inclusion of a Lagrangian biotic phase to provide the microbial perspective.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-ef224fe e-con-full e-flex e-con e-child" data-id="ef224fe" data-element_type="container"> <div class="elementor-element elementor-element-e904344 e-con-full e-flex e-con e-child" data-id="e904344" data-element_type="container"> <div class="elementor-element elementor-element-bdb2157 elementor-widget elementor-widget-image" data-id="bdb2157" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="114" height="150" src="https://mstarcfd.com/wp-content/uploads/aic.v68.3.cover_.jpg" class="attachment-large size-large wp-image-3214" alt="" /> </div> </div> </div> <div class="elementor-element elementor-element-4131b02 e-con-full e-flex e-con e-child" data-id="4131b02" data-element_type="container"> <div class="elementor-element elementor-element-810af8f elementor-widget elementor-widget-text-editor" data-id="810af8f" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://doi.org/10.1002/aic.17667" target="_blank" rel="noreferrer noopener">Predicting the diameters of droplets produced in turbulent liquid鈥搇iquid dispersion</a></strong><br /><em>AiCHE Journal (February 2022)</em><br />John A. Thomas, Brian DeVincentis, Johannes Wutz, Francesco Ricci</p><p>The droplet size distribution in liquid鈥搇iquid dispersions is a complex convolution of impeller speed, impeller type, fluid properties, and flow conditions. In this work with Boehringer Ingelheim, we present three聽<em>a priori</em>聽modeling approaches for predicting the droplet diameter distributions as a function of system operating conditions.聽</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-cae1141 e-con-full e-flex e-con e-child" data-id="cae1141" data-element_type="container"> <div class="elementor-element elementor-element-2665fed e-con-full e-flex e-con e-child" data-id="2665fed" data-element_type="container"> <div class="elementor-element elementor-element-6923090 elementor-widget elementor-widget-image" data-id="6923090" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="149" height="200" src="https://mstarcfd.com/wp-content/uploads/1-s2.0-S0009250922X0002X-cov200h.gif" class="attachment-large size-large wp-image-3215" alt="" /> </div> </div> </div> <div class="elementor-element elementor-element-fb56c96 e-con-full e-flex e-con e-child" data-id="fb56c96" data-element_type="container"> <div class="elementor-element elementor-element-1f3a451 elementor-widget elementor-widget-text-editor" data-id="1f3a451" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://www.sciencedirect.com/science/article/pii/S0009250921009763" target="_blank" rel="noreferrer noopener">Computational prediction of the just-suspended speed, Njs, in stirred vessels using the Lattice Boltzmann method (LBM) coupled with a novel mathematical approach</a></strong><br /><em>Chemical Engineering Science (January 2022)</em><br />Chadakarn Sirasitthichoke, Baran Teoman, John Thomas, Piero M. Armenante</p><p>Determining the minimum agitation speed to achieve suspension of solids and liquids in a stirred vessel is of significant importance in industrial processes. In this article published jointly with M-Star and New Jersey Institute of Technology, the just-suspended speed is computationally predicted for a stirred, fully baffled vessel provided with different axial or radial impellers using M-Star CFD, coupled with a novel mathematical method.聽</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-4bd8735 e-con-full e-flex e-con e-child" data-id="4bd8735" data-element_type="container"> <div class="elementor-element elementor-element-03011aa e-con-full e-flex e-con e-child" data-id="03011aa" data-element_type="container"> <div class="elementor-element elementor-element-7fa5c26 elementor-widget elementor-widget-image" data-id="7fa5c26" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="149" height="200" src="https://mstarcfd.com/wp-content/uploads/1-s2.0-S0009250921X00152-cov200h.gif" class="attachment-large size-large wp-image-3216" alt="" /> </div> </div> </div> <div class="elementor-element elementor-element-3541749 e-con-full e-flex e-con e-child" data-id="3541749" data-element_type="container"> <div class="elementor-element elementor-element-7116407 elementor-widget elementor-widget-text-editor" data-id="7116407" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="http://sciencedirect.com/science/article/pii/S0009250921007119" target="_blank" rel="noreferrer noopener">Modeling Mass Transfer in Stirred Microbioreactors</a></strong><br /><em>Chemical Engineering Science (2022)</em><br />Hooman Farsani, Johannes Wutz, Brian DeVincentis, John A Thomas, Seyed Pouria Motevalian</p><p>Microbioreactors play a pivotal role in making biologic medicines. In fact, 10 of the top 15 selling drugs worldwide were made in a bioreactor. In this paper, M-Star and Pfizer present a generalized framework for modeling mass transfer in two-stage, stirred tank bioreactors to aid the聽scale-up process.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-a3862bc e-con-full e-flex e-con e-child" data-id="a3862bc" data-element_type="container"> <div class="elementor-element elementor-element-6218df6 e-con-full e-flex e-con e-child" data-id="6218df6" data-element_type="container"> <div class="elementor-element elementor-element-7633716 elementor-widget elementor-widget-image" data-id="7633716" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="306" height="464" src="https://mstarcfd.com/wp-content/uploads/processes.jpg" class="attachment-large size-large wp-image-3217" alt="" srcset="https://mstarcfd.com/wp-content/uploads/processes.jpg 306w, https://mstarcfd.com/wp-content/uploads/processes-198x300.jpg 198w" sizes="auto, (max-width: 306px) 100vw, 306px" /> </div> </div> </div> <div class="elementor-element elementor-element-9488f30 e-con-full e-flex e-con e-child" data-id="9488f30" data-element_type="container"> <div class="elementor-element elementor-element-89ad9ad elementor-widget elementor-widget-text-editor" data-id="89ad9ad" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="http://mdpi.com/2227-9717/9/6/950/htm" target="_blank" rel="noreferrer noopener">Validation of Novel Lattice Boltzmann Large Eddy Simulations (LB LES) for Equipment Characterization in Biopharma</a></strong><br /><em>Processes (2021</em>)<br />Maike Kuschel, J眉rgen Fitschen, Marko Hoffmann, Alexandra von Kameke, Michael Schl眉ter, Thomas Wucherpfennig</p><p>In this study, transient LB LES were applied to simulate a 3 L bioreactor system. The results were compared to novel 4D particle tracking (4D PTV) experiments, which resolve the motion of thousands of passive tracer particles on their journey through the bioreactor.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-9617f31 e-con-full e-flex e-con e-child" data-id="9617f31" data-element_type="container"> <div class="elementor-element elementor-element-f5de2bd e-con-full e-flex e-con e-child" data-id="f5de2bd" data-element_type="container"> <div class="elementor-element elementor-element-f834b33 elementor-widget elementor-widget-image" data-id="f834b33" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="306" height="464" src="https://mstarcfd.com/wp-content/uploads/aaps.jpg" class="attachment-large size-large wp-image-3218" alt="" srcset="https://mstarcfd.com/wp-content/uploads/aaps.jpg 306w, https://mstarcfd.com/wp-content/uploads/aaps-198x300.jpg 198w" sizes="auto, (max-width: 306px) 100vw, 306px" /> </div> </div> </div> <div class="elementor-element elementor-element-c4de159 e-con-full e-flex e-con e-child" data-id="c4de159" data-element_type="container"> <div class="elementor-element elementor-element-e15c53b elementor-widget elementor-widget-text-editor" data-id="e15c53b" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="http://link.springer.com/article/10.1208/s12249-021-01972-5" target="_blank" rel="noreferrer noopener">A CFD Digital Twin to Understand Miscible Fluid Blending</a></strong><br /><em>AAPS PharmSciTech聽(2021)</em><br />John Thomas, Kushal Sinha, Gayathri Shivkumar, Lei Cao, Marina Funck, Sherwin Shang, Nandkishor K. Nere</p><p>The mixing of stratified miscible fluids with widely different material properties is a common step in biopharmaceutical manufacturing processes. Differences between the fluid densities and viscosities, however, can lead to order-of-magnitude increase in blend times relative to the blending of single-fluid systems. In this work, M-Star and AbbVie build accelerated digital twins of a physical mixing tank to predict real-time fluid mechanics with a fidelity that rivals experimental data.聽</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-09798a5 e-con-full e-flex e-con e-child" data-id="09798a5" data-element_type="container"> <div class="elementor-element elementor-element-1f6055e e-con-full e-flex e-con e-child" data-id="1f6055e" data-element_type="container"> <div class="elementor-element elementor-element-d59d178 elementor-widget elementor-widget-image" data-id="d59d178" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="306" height="464" src="https://mstarcfd.com/wp-content/uploads/11.jpg" class="attachment-large size-large wp-image-3219" alt="" srcset="https://mstarcfd.com/wp-content/uploads/11.jpg 306w, https://mstarcfd.com/wp-content/uploads/11-198x300.jpg 198w" sizes="auto, (max-width: 306px) 100vw, 306px" /> </div> </div> </div> <div class="elementor-element elementor-element-fe8df66 e-con-full e-flex e-con e-child" data-id="fe8df66" data-element_type="container"> <div class="elementor-element elementor-element-5f408ee elementor-widget elementor-widget-text-editor" data-id="5f408ee" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="http://sciencedirect.com/science/article/pii/S0009250921001032" target="_blank" rel="noreferrer noopener">A Mechanistic Approach for Predicting Mass Transfer in Bioreactors</a></strong><br /><em>Chemical Engineering Science聽(2021)</em><br />John A. Thomas, Xiaoming Liu, Brian DeVincentis, Helen Hua, Grace Yao, Michael C. Borys, Kathryn Aron, Girish Pendse</p><p>In this work, M-Star pairs with Bristol Myers Squibb to propose, implement, and validate a mechanistic transport model for predicting oxygen transfer rates within stirred tank bioreactors. To begin, we describe the relevant conservation laws and key principles from turbulence theory that govern mass transfer.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-aa6f4e1 e-con-full e-flex e-con e-child" data-id="aa6f4e1" data-element_type="container"> <div class="elementor-element elementor-element-0a3bdff e-con-full e-flex e-con e-child" data-id="0a3bdff" data-element_type="container"> <div class="elementor-element elementor-element-6250898 elementor-widget elementor-widget-image" data-id="6250898" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="306" height="464" src="https://mstarcfd.com/wp-content/uploads/3.jpg" class="attachment-large size-large wp-image-3220" alt="" srcset="https://mstarcfd.com/wp-content/uploads/3.jpg 306w, https://mstarcfd.com/wp-content/uploads/3-198x300.jpg 198w" sizes="auto, (max-width: 306px) 100vw, 306px" /> </div> </div> </div> <div class="elementor-element elementor-element-4752c42 e-con-full e-flex e-con e-child" data-id="4752c42" data-element_type="container"> <div class="elementor-element elementor-element-57db96a elementor-widget elementor-widget-text-editor" data-id="57db96a" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="http://sciencedirect.com/science/article/pii/S2590140021000113" target="_blank" rel="noreferrer noopener">Novel Evaluation Method to Determine the Local Mixing Time Distribution in Stirred Tank Reactors</a></strong><br /><em>Chemical Engineering Science: X聽(2021)</em><br />J. Fitschen, S. Hofmann, J. Wutz, A.v. Kameke, M. Hoffmann, T. Wucherpfennig, M. Schl眉ter</p><p>A novel image analysis will be presented in this study for the detailed characterization of mixing processes by taking into account the history of mixing. The method is based on the experimental determination of the local mixing time distribution by using a multi-color change caused by a pH-change in a bromothymol blue solution.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-481534b e-con-full e-flex e-con e-child" data-id="481534b" data-element_type="container"> <div class="elementor-element elementor-element-e55335f e-con-full e-flex e-con e-child" data-id="e55335f" data-element_type="container"> <div class="elementor-element elementor-element-e86b708 elementor-widget elementor-widget-image" data-id="e86b708" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="306" height="464" src="https://mstarcfd.com/wp-content/uploads/1-1.jpg" class="attachment-large size-large wp-image-3221" alt="" srcset="https://mstarcfd.com/wp-content/uploads/1-1.jpg 306w, https://mstarcfd.com/wp-content/uploads/1-1-198x300.jpg 198w" sizes="auto, (max-width: 306px) 100vw, 306px" /> </div> </div> </div> <div class="elementor-element elementor-element-64e464d e-con-full e-flex e-con e-child" data-id="64e464d" data-element_type="container"> <div class="elementor-element elementor-element-032cdf1 elementor-widget elementor-widget-text-editor" data-id="032cdf1" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><a href="http://link.springer.com/article/10.1007%2Fs10494-019-00095-z" target="_blank" rel="noreferrer noopener"><strong>Time Scales and Turbulent Spectra above the Base of Stirred Vessels from Large Eddy Simulations</strong></a><br /><em>Flow, Turbulence and Combustion (2020)</em><br />Jason J. Giacomelli, Harry E. A. Van den Akker</p><p>Single-phase Large Eddy Simulations (LESs) have been conducted with M-Star CFD software to compute spectra and time scales of the turbulent flow field at positions above the base of a stirred tank as these time scales may be important to the application of solids suspension.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-8561b3c e-con-full e-flex e-con e-child" data-id="8561b3c" data-element_type="container"> <div class="elementor-element elementor-element-9523182 e-con-full e-flex e-con e-child" data-id="9523182" data-element_type="container"> <div class="elementor-element elementor-element-9813351 elementor-widget elementor-widget-image" data-id="9813351" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="306" height="464" src="https://mstarcfd.com/wp-content/uploads/1-1-1.jpg" class="attachment-large size-large wp-image-3222" alt="" srcset="https://mstarcfd.com/wp-content/uploads/1-1-1.jpg 306w, https://mstarcfd.com/wp-content/uploads/1-1-1-198x300.jpg 198w" sizes="auto, (max-width: 306px) 100vw, 306px" /> </div> </div> </div> <div class="elementor-element elementor-element-13dd0e3 e-con-full e-flex e-con e-child" data-id="13dd0e3" data-element_type="container"> <div class="elementor-element elementor-element-78231fe elementor-widget elementor-widget-text-editor" data-id="78231fe" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><a href="https://aiche.onlinelibrary.wiley.com/doi/abs/10.1002/aic.17097" target="_blank" rel="noreferrer noopener">A Spectral Approach of Suspending Solid Particles in a Turbulent Stirred Vessel</a></strong><br /><em>Transport Phenomena and Fluid Mechanics (2020)</em><br />Jason J. Giacomelli, Harry E. A. Van den Akker</p><p>The 2015 Grenville-Mak-Brown (GMB) correlation for predicting the just suspended condition assumes that the length scale of the suspending eddy is equivalent to the particle diameter. This article investigates the role of the time scale of the relevant eddies with respect to the particle response time.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div data-elementor-type="footer" data-elementor-id="40" class="elementor elementor-40 elementor-location-footer" data-elementor-post-type="elementor_library"> <div class="elementor-element elementor-element-7d7752c3 e-flex e-con-boxed e-con e-parent" data-id="7d7752c3" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-788618e8 e-con-full e-flex e-con e-child" data-id="788618e8" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="elementor-element elementor-element-786fd3ff elementor-widget elementor-widget-button" data-id="786fd3ff" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div 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