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width="1.25rem" xmlns="http://www.w3.org/2000/svg"><polyline points="6 9 6 2 18 2 18 9"></polyline><path d="M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2"></path><rect x="6" y="14" width="12" height="8"></rect></svg></a></button></div></div><div><div class="flex flex-wrap"><p class=" text-primary font-semibold">Commentary</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1"></div><p class=" text-primary font-semibold">Article</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1 "></div><time class="text-gray-500 " dateTime="2024-09-12T13:00:00.000">September 12, 2024</time></div><h1 class="text-[26px] font-medium leading-8">Dr Dax Kurbegov on Gaps Between Payers, Health Systems, and Providers in Oncology</h1><div class="py-3 text-gray-600 md:flex flex-col md:justify-between"><div class="flex flex-col xs:flex-row"><p class="mr-1 self-start">Author(s):</p><div class="flex flex-col xs:flex-row mb-3 md:mb-0"><div class="flex flex-wrap"><span class="text-md mr-2"><a class="text-author text-gray-500 hover:text-primary underline hover:no-underline decoration-gray-400" href="/authors/rose-mcnulty">Rose McNulty</a></span></div></div></div><div class="max-w-full"><div class="flex flex-wrap sm:flex-nowrap items-center w-fit my-2"></div><div class="w-full flex flex-col sm:flex-row justify-between mt-2"><div class="block md:hidden "><div class="mt-2 flex items-center max-w-fit"><button title="Dr Dax Kurbegov on Gaps Between Payers, Health Systems, and Providers in Oncology" aria-label="facebook" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#3b5998"></circle><path d="M34.1,47V33.3h4.6l0.7-5.3h-5.3v-3.4c0-1.5,0.4-2.6,2.6-2.6l2.8,0v-4.8c-0.5-0.1-2.2-0.2-4.1-0.2 c-4.1,0-6.9,2.5-6.9,7V28H24v5.3h4.6V47H34.1z" fill="white"></path></svg></button><button 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background: #7F7F7F; color: white; padding: 2px; border-radius: 100%; } </style></div></div></div></div><div class=" lg:w-full flex flex-col lg:flex-row lg:items-center lg:justify-end"></div><p class="py-2 mb-2 text-sm italic text-gray-600">Dax Kurbegov, MD, senior vice president of Sarah Cannon Cancer Network, discussed divides between payers, health systems, and oncology care providers, as well as the impacts these divides can have on patients. </p><div class="py-2"><div class="blockText_blockContent__TbCXh"><div class="relative"><div class="brightcove-fluid" autoplay=""></div></div><p class="pb-2"></p><p class="pb-2">Dax Kurbegov, MD, senior vice president of Sarah Cannon Cancer Network, discussed factors contributing to divides between payers, health systems, and oncology care providers, as well as the impacts they can have on patient outcomes. </p><p class="pb-2"></p><p class="pb-2"><strong><span style="text-decoration:underline">Transcript</span></strong></p><p class="pb-2"><strong>From your perspective, what are the key factors driving the divide between payers, health systems, and providers in oncology care?<br/></strong></p><p class="pb-2">I don't know that I've got earth-shattering news here. I think we have a pretty good understanding of what some of the gaps are that really preclude us—between health system, provider, and payer—working as effectively as we can in support of the best patient outcomes, right? </p><p class="pb-2"></p><p class="pb-2">The first is simply misaligned incentives, that we're not always on the same page. And we don't always incentivize the type of coordination or collaborative activity that we know is patient centered and leads to better care. A very tangible manifestation of that is just how siloed we are from a data perspective. You know, the recognition that the acute care setting, where I spend most of my time, has very limited insight—in most oncologic circumstances—to what happens on the outpatient side, or particularly in terms of long-term outcomes. My doctors, our teams all the time really, want to look at long-term outcomes, relapse-free survival, overall survival. And yet, obviously, from my perspective, much of that occurs outside of the hospital. And yet, we should have a vested interest in knowing what happens there so that we can achieve the best outcome. </p><p class="pb-2"></p><p class="pb-2">The last piece, [that's] probably not always called out, is just the fact that we we don't do as good a job as I think we should in incentivizing, encouraging, and achieving patient enrollment in clinical trials. I'm a big fan of clinical trials, one because the very least that our patients get when they participate in clinical trials—and that might not be the right word—is the best care that we know how to give for that situation, for that cancer, at the time. And the most exciting possible outcome is that they're receiving a cutting-edge therapy that's going to prove to be more effective, less toxic, and more durable than historical therapy. And you know, in those circumstances, patients win, providers win, the research community and the field wins. And of course, because those drugs are often provided as part of the clinical trial, the overall cost of care is reduced. If we can make those offerings available close to home, we win on many fronts. </p><p class="pb-2"></p><p class="pb-2"><br/><strong>How can this divide affect patient outcomes, particularly in cases where time and access to cutting-edge treatments are critical?</strong></p><p class="pb-2">The first one is exactly what your question asks, right? If we don't address those gaps, then we have functionally reduced access that patients have to cutting-edge therapy. If you don't know what's available to you and where it's available, then you can't make informed decisions. If you don't understand the treatment options and the benefits and risks associated with those different treatment options, then you can't make good decisions as to where best to pursue therapy. </p><p class="pb-2"></p><p class="pb-2">If we don't have the kind of dialogue that we referenced earlier—that is, if we don't look at where the patient is, what their circumstance is—then we functionally can't address the barriers that might exist for them to receive cutting-edge therapy, whether those are local barriers, just in terms of childcare or finances, or whether those are broader barriers in terms of ability to travel or ability to come in daily for therapy where that's necessary.</p></div></div><div class="flex items-center lg:w-3/4 mb-4 pb-12"></div><div class="jsx-19ede9f0a5a45918 py-4 relative bg-primary md:px-8 -ml-6 xs:ml-0 w-screen xs:w-auto"><div class="jsx-19ede9f0a5a45918 px-4 sm:px-0"><div class="flex justify-between items-center py-1 space-x-4 border-0 select-none 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class="hidden lg:flex w-full flex-col justify-end items-end"><div class="hidden w-full lg:flex flex-wrap pb-2 gap-x-2 gap-y-1 justify-end items-end"></div></div></div><div class="w-full mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/2025-gold-report-new-insights-on-copd-risks-management?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6418bb32610c66a6b058609e8b3c2d21368ccb96-4200x3900.jpg?fit=crop&auto=format" alt="COPD illustration | Image Credit: peterschreiber.media - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/2025-gold-report-new-insights-on-copd-risks-management?utm_source=www.ajmc.com&utm_medium=relatedContent">2025 GOLD Report: New Insights on COPD Risks, Management</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/tim-smith">Tim Smith</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/2025-gold-report-new-insights-on-copd-risks-management?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The 2025 Global Initiative for Chronic Obstructive Lung Disease (GOLD) report highlighted climate change, cardiovascular risk, and pulmonary hypertension.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/operationalizing-bispecifics-in-multiple-myeloma?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="managed care cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/operationalizing-bispecifics-in-multiple-myeloma?utm_source=www.ajmc.com&utm_medium=relatedContent">Operationalizing Bispecifics in Multiple Myeloma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/operationalizing-bispecifics-in-multiple-myeloma?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Tyler Sandahl, PharmD, of Mayo Clinic, and Michael Byrne, DO, of Tennessee Oncology, discuss practical advice for bringing bispecifics to the community.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f1f12e9d502c73f75e8062c6dd726c422c8aff78-4320x3473.jpg?fit=crop&auto=format" alt="FDA Approval | image credit: gomixer - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent">FDA Approves Imatinib Oral Solution for Treatment of Various Cancers</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA approval marks the first oral solution indicated for patients with different forms of leukemia. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/expert-insights-on-how-utilization-management-drives-physician-burnout?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="managed care cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/expert-insights-on-how-utilization-management-drives-physician-burnout?utm_source=www.ajmc.com&utm_medium=relatedContent">Expert Insights on How Utilization Management Drives Physician Burnout</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/expert-insights-on-how-utilization-management-drives-physician-burnout?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we speak with the author of a study published in the November 2024 issue of The American Journal of Managed Care® to explore the link between utilization management and physician burnout. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/shaping-the-future-of-cardiology-key-takeaways-from-aha-2024?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/49c254ee4b48052a1a8384c9a7285c4f028cf08d-303x240.svg?fit=crop&auto=format" alt="This year marks the 100th year of the American Heart Association | image credit: www.heart.org" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/shaping-the-future-of-cardiology-key-takeaways-from-aha-2024?utm_source=www.ajmc.com&utm_medium=relatedContent">Shaping the Future of Cardiology: Key Takeaways From AHA 2024</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/shaping-the-future-of-cardiology-key-takeaways-from-aha-2024?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Attendees of the centennial American Heart Association (AHA) conference commend the meeting's ability to bring together diverse, interdisciplinary perspectives from across the globe. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/be-heard-trials-highlight-efficacy-of-bimekizumab-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/758a0de566362b3ad859754c1250dd77346ec42d-1200x738.jpg?fit=crop&auto=format" alt="Christopher Sayed, MD, UNC Chapel Hill" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/be-heard-trials-highlight-efficacy-of-bimekizumab-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent">BE HEARD Trials Highlight Efficacy of Bimekizumab in Hidradenitis Suppurativa</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/be-heard-trials-highlight-efficacy-of-bimekizumab-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On November 20, the FDA approved bimekizumab (Bimzelx; UCB Pharma) for use in patients with moderate to severe hidradenitis suppurativa.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="relative hidden sm:block"><div class="mt-4 overflow-hidden"><div class="flex justify-between"><div class="flex items-center clear-both pt-4 pb-2 text-3xl lg:text-2xl xl:text-3xl min-w-fit ">Related Content </div><div class="hidden lg:flex w-full flex-col justify-end items-end"><div class="hidden w-full lg:flex flex-wrap pb-2 gap-x-2 gap-y-1 justify-end items-end"></div></div></div><div class="w-full mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/2025-gold-report-new-insights-on-copd-risks-management?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6418bb32610c66a6b058609e8b3c2d21368ccb96-4200x3900.jpg?fit=crop&auto=format" alt="COPD illustration | Image Credit: peterschreiber.media - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/2025-gold-report-new-insights-on-copd-risks-management?utm_source=www.ajmc.com&utm_medium=relatedContent">2025 GOLD Report: New Insights on COPD Risks, Management</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/tim-smith">Tim Smith</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/2025-gold-report-new-insights-on-copd-risks-management?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The 2025 Global Initiative for Chronic Obstructive Lung Disease (GOLD) report highlighted climate change, cardiovascular risk, and pulmonary hypertension.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/operationalizing-bispecifics-in-multiple-myeloma?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="managed care cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/operationalizing-bispecifics-in-multiple-myeloma?utm_source=www.ajmc.com&utm_medium=relatedContent">Operationalizing Bispecifics in Multiple Myeloma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/operationalizing-bispecifics-in-multiple-myeloma?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Tyler Sandahl, PharmD, of Mayo Clinic, and Michael Byrne, DO, of Tennessee Oncology, discuss practical advice for bringing bispecifics to the community.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f1f12e9d502c73f75e8062c6dd726c422c8aff78-4320x3473.jpg?fit=crop&auto=format" alt="FDA Approval | image credit: gomixer - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent">FDA Approves Imatinib Oral Solution for Treatment of Various Cancers</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA approval marks the first oral solution indicated for patients with different forms of leukemia. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/expert-insights-on-how-utilization-management-drives-physician-burnout?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="managed care cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/expert-insights-on-how-utilization-management-drives-physician-burnout?utm_source=www.ajmc.com&utm_medium=relatedContent">Expert Insights on How Utilization Management Drives Physician Burnout</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/expert-insights-on-how-utilization-management-drives-physician-burnout?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we speak with the author of a study published in the November 2024 issue of The American Journal of Managed Care® to explore the link between utilization management and physician burnout. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/shaping-the-future-of-cardiology-key-takeaways-from-aha-2024?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/49c254ee4b48052a1a8384c9a7285c4f028cf08d-303x240.svg?fit=crop&auto=format" alt="This year marks the 100th year of the American Heart Association | image credit: www.heart.org" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/shaping-the-future-of-cardiology-key-takeaways-from-aha-2024?utm_source=www.ajmc.com&utm_medium=relatedContent">Shaping the Future of Cardiology: Key Takeaways From AHA 2024</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/shaping-the-future-of-cardiology-key-takeaways-from-aha-2024?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Attendees of the centennial American Heart Association (AHA) conference commend the meeting's ability to bring together diverse, interdisciplinary perspectives from across the globe. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/be-heard-trials-highlight-efficacy-of-bimekizumab-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/758a0de566362b3ad859754c1250dd77346ec42d-1200x738.jpg?fit=crop&auto=format" alt="Christopher Sayed, MD, UNC Chapel Hill" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/be-heard-trials-highlight-efficacy-of-bimekizumab-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent">BE HEARD Trials Highlight Efficacy of Bimekizumab in Hidradenitis Suppurativa</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/be-heard-trials-highlight-efficacy-of-bimekizumab-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On November 20, the FDA approved bimekizumab (Bimzelx; UCB Pharma) for use in patients with moderate to severe hidradenitis suppurativa.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="pb-24"></div></div><script type="application/ld+json">{"@context":"https://schema.org","@type":"NewsArticle","headline":"Dr Dax Kurbegov on Gaps Between Payers, Health Systems, and Providers in Oncology","datePublished":"2024-09-12T13:00:00.000Z","dateModified":"2024-09-12T13:00:26Z","inLanguage":"en-US","image":"https://cdn.sanity.io/images/0vv8moc6/ajmc/99bc0df591ee95a610566a8f2090e472f9392143-640x359.png?fit=crop&auto=format","mainEntityOfPage":{"@type":"WebPage","@id":"https://www.ajmc.com/view/dr-dax-kurbegov-on-the-divide-between-payers-health-systems-and-providers-in-oncology"},"publisher":{"@type":"Organization","name":"AJMC","logo":{"@type":"ImageObject","url":"https://www.ajmc.com/ajmc_logo_inverted.png"}},"keywords":"Dax Kurbegov, MD,oncology care,AJMC IVBM","articleBody":"\n\n\n\nDax Kurbegov, MD, senior vice president of Sarah Cannon Cancer Network, discussed factors contributing to divides between payers, health systems, and oncology care providers, as well as the impacts they can have on patient outcomes. \n\n\n\nTranscript\n\nFrom your perspective, what are the key factors driving the divide between payers, health systems, and providers in oncology care?\n\n\nI don't know that I've got earth-shattering news here. I think we have a pretty good understanding of what some of the gaps are that really preclude us—between health system, provider, and payer—working as effectively as we can in support of the best patient outcomes, right? \n\n\n\nThe first is simply misaligned incentives, that we're not always on the same page. And we don't always incentivize the type of coordination or collaborative activity that we know is patient centered and leads to better care. A very tangible manifestation of that is just how siloed we are from a data perspective. You know, the recognition that the acute care setting, where I spend most of my time, has very limited insight—in most oncologic circumstances—to what happens on the outpatient side, or particularly in terms of long-term outcomes. My doctors, our teams all the time really, want to look at long-term outcomes, relapse-free survival, overall survival. And yet, obviously, from my perspective, much of that occurs outside of the hospital. And yet, we should have a vested interest in knowing what happens there so that we can achieve the best outcome. \n\n\n\nThe last piece, [that's] probably not always called out, is just the fact that we we don't do as good a job as I think we should in incentivizing, encouraging, and achieving patient enrollment in clinical trials. I'm a big fan of clinical trials, one because the very least that our patients get when they participate in clinical trials—and that might not be the right word—is the best care that we know how to give for that situation, for that cancer, at the time. And the most exciting possible outcome is that they're receiving a cutting-edge therapy that's going to prove to be more effective, less toxic, and more durable than historical therapy. And you know, in those circumstances, patients win, providers win, the research community and the field wins. And of course, because those drugs are often provided as part of the clinical trial, the overall cost of care is reduced. If we can make those offerings available close to home, we win on many fronts. \n\n\n\n\nHow can this divide affect patient outcomes, particularly in cases where time and access to cutting-edge treatments are critical?\n\nThe first one is exactly what your question asks, right? If we don't address those gaps, then we have functionally reduced access that patients have to cutting-edge therapy. If you don't know what's available to you and where it's available, then you can't make informed decisions. If you don't understand the treatment options and the benefits and risks associated with those different treatment options, then you can't make good decisions as to where best to pursue therapy. \n\n\n\nIf we don't have the kind of dialogue that we referenced earlier—that is, if we don't look at where the patient is, what their circumstance is—then we functionally can't address the barriers that might exist for them to receive cutting-edge therapy, whether those are local barriers, just in terms of childcare or finances, or whether those are broader barriers in terms of ability to travel or ability to come in daily for therapy where that's necessary.","description":"Dax Kurbegov, MD, senior vice president of Sarah Cannon Cancer Network, discussed divides between payers, health systems, and oncology care providers, as well as the impacts these divides can have on patients. 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You know, the recognition that the acute care setting, where I spend most of my time, has very limited insight—in most oncologic circumstances—to what happens on the outpatient side, or particularly in terms of long-term outcomes. My doctors, our teams all the time really, want to look at long-term outcomes, relapse-free survival, overall survival. And yet, obviously, from my perspective, much of that occurs outside of the hospital. And yet, we should have a vested interest in knowing what happens there so that we can achieve the best outcome. 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And the most exciting possible outcome is that they're receiving a cutting-edge therapy that's going to prove to be more effective, less toxic, and more durable than historical therapy. And you know, in those circumstances, patients win, providers win, the research community and the field wins. And of course, because those drugs are often provided as part of the clinical trial, the overall cost of care is reduced. If we can make those offerings available close to home, we win on many fronts. 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Shorla Oncology announces FDA approval of IMKELDI (imatinib) oral solution, an oral liquid for the treatment of certain forms of leukemia and other cancers. News release. Shorla Oncology. November 25, 2024. Accessed November 26, 2024. "},{"_key":"fcc66983d1cc1","_type":"span","marks":["ae7780cb14be"],"text":"https://www.businesswire.com/news/home/20241125044117/en/Shorla-Oncology-Announces-FDA-Approval-of-IMKELDI-imatinib-Oral-Solution-an-Oral-Liquid-for-the-Treatment-of-Certain-Forms-of-Leukemia-and-Other-Cancers"}],"_type":"block","style":"normal","_key":"2e3ed5d87cb6"},{"markDefs":[{"_type":"link","href":"https://www.cancer.org/cancer/types/acute-lymphocytic-leukemia/about/key-statistics.html","_key":"1721013932bc","nofollow":true,"blank":true}],"children":[{"_type":"span","marks":[],"text":"2. Key statistics for acute lymphoblastic leukemia (ALL). American Cancer Society. Updated January 17, 2024. Accessed November 26, 2024. 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I mean, cardiology is the big one that stands out because it's American Heart [Association], but there’s also radiology, neurology, nephrology, lifestyle interventions, the basic sciences, epidemiology—trying to figure out what's going on out there.","_key":"7b5a5c4452671","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"916b80cdc5ed","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"You get this group together, it's a very diverse group, and everyone's vying for their attention. But at the same time, I think people forget this is where we find the crossover ideas, where you can bring the professionals together. That's one of the areas where I am good at doing research. I have some good ideas, but I'm not an expert in the biomarkers. I'm not an expert in the advanced clinical imaging. So, I find those experts from those different areas.","_key":"86ba76fa9384"}],"_type":"block","style":"normal","_key":"fc4258755f37"},{"children":[{"_key":"d1c8586499fd0","_type":"span","marks":[],"text":"Most of my research is multidisciplinary, and I think that is the forte of American Heart [Association]. It brings these different disciplines together in the same meeting, talking to one another, and in the planning of our sessions, we're talking to one another to bring in the expertise from the different areas on the topics that are important."}],"_type":"block","style":"normal","_key":"e7b98aa763e1","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"cbc3fb4334180"}],"_type":"block","style":"normal","_key":"a327c5cf04ca"},{"markDefs":[],"children":[{"text":"Cathie Biga, MSN, FACC","_key":"3ce5957d5ae10","_type":"span","marks":["strong"]},{"marks":[],"text":": The house of cardiology is critical, and not only AHA, ACC [American College of Cardiology], [Heart Rhythm Society], [Society for Cardiovascular Angiography \u0026 Interventions]—all of our societies together. The whole house of cardiology. It's imperative that we're all at that table, because the continuum of cardiovascular care not only has gotten enormously complicated, but the breadth and the depth and the rapidity of the change and the science that continues to astound as you listen to all the late-breaking trials—even here this morning already. That's what we need, and those ongoing, continuous educational opportunities will come together. Boards will never be stagnant. They will always be a dynamic process, and without meetings such as ACC and AHA, that wouldn't be able to happen.","_key":"3ce5957d5ae11","_type":"span"}],"_type":"block","style":"normal","_key":"9360ff8e3013"},{"style":"normal","_key":"dc7c47002673","markDefs":[],"children":[{"_key":"d71b414e8e680","_type":"span","marks":[],"text":"So it's not just the networking and the presentation of the science, but it's really that in depth ability to be able to talk to the principal investigators, to really understand their research and the ins and the outs of it, and then that will then translate into perhaps exam questions or other vehicles that physicians can utilize in order to continue their maintenance of competency and certification."}],"_type":"block"},{"_type":"block","style":"normal","_key":"965c76210367","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"92ed2d7644da0"}]},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Khadijah Breathett, MD","_key":"2d84722f55220"},{"_key":"2d84722f55221","_type":"span","marks":[],"text":": This is the centennial year—a wonderful time and place to be for global science to be presented. I think one of the great things about American Heart Association is that it's not just cardiologists. We have physicians from internal medicine to endocrinology to neurology, and the list goes on, and PhD scientists and master’s scientists all thinking about, “How can we improve the health of the heart for individuals in this nation and around the world?”"}],"_type":"block","style":"normal","_key":"14dcd173743c"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"And the science is not just, like, I'm more of a clinical research and population health research, but there's also basic science and translational research. And so, it's really the whole gamut here, and it's a great opportunity to learn about the late breaking trials, and the things that you may be able to bring back home to your respective hospitals and clinics to improve the care of your patients. So, it's a great time to be here, and a great time for wonderful science.","_key":"328312c53cd70"}],"_type":"block","style":"normal","_key":"306a6c3c8eb6"},{"children":[{"_type":"span","marks":[],"text":"","_key":"ef8fd2ffc0020"}],"_type":"block","style":"normal","_key":"b36806b7d323","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Masanori Aikawa, MD, PhD","_key":"f911aa78305f0"},{"_type":"span","marks":[],"text":": What we have been trying to accomplish at the AHA meeting, and then what we should do more is, integration between clinicians and basic research scientists. You know, there are some sessions that feature both basic research scientists, for example, vascular biologist and cardiologist or cardiovascular surgeon, and to discuss 1 clinical program from different angles. This is extremely important, and then those scientists or clinicians from different disciplines should work together. Sometimes, practically speaking, it's not so easy to do. Everybody's busy, but this is something we really should do.","_key":"f911aa78305f1"}],"_type":"block","style":"normal","_key":"3df9b3ee0eff"},{"children":[{"text":"Another aspect of this is a computational kind of method that has been developing very, very quickly. You know, that supports you. Our systems approach, for example. So therefore, in my group, we have biologists and computational data scientists who are working together in the shared space. This is 1 example of a integrated research approach: clinician and scientist and cardiovascular scientist and data scientist. We should all work together to ask 1 question and then try to resolve 1 problem together—and also academia and industry collaboration is very, very powerful to speed up the process of drug development. For example, diagnostics and the device companies are very, very powerful too. As a community, we really should work together and go kind of beyond the boundaries and practical challenges that we can potentially face.","_key":"d68c0be832ea0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"16cc33028d6f","markDefs":[]},{"_type":"block","style":"normal","_key":"5096e22913c1","markDefs":[],"children":[{"_key":"2f9958ddf3d90","_type":"span","marks":[],"text":""}]},{"_key":"58e27047fbc1","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Milind Desai, MD","_key":"b897e628d03c0"},{"text":": I think, we are truly living in the “Renaissance Age” of therapeutic development, especially in cardiology. If you talk about [hypertrophic cardiomyopathy], there's all these new therapies that are being tested. There's gene therapy down the horizon that may change how we look at things. There's a huge field—burgeoning field—of anti-obesity drugs that, whatever patient population they're being tested in, it is hitting a home run.","_key":"b897e628d03c1","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"So, I think the future is tremendously bright in the sense that we are now recognizing that it's not a one size fits all. It's not a one drug fits all. We have to look at the patient as a whole, work on their comorbidities, work on the risk factors, and a lot of things flow in the same direction.","_key":"c6f2a36690e9"}],"_type":"block","style":"normal","_key":"f0a0c7924020","markDefs":[]}],"_updatedAt":"2024-11-26T15:28:05Z","published":"2024-11-26T15:28:03.913Z","_type":"article","articleType":"Commentary","factCheckAuthorMapping":null,"_createdAt":"2024-11-25T15:48:58Z","documentGroupMapping":[{"_updatedAt":"2024-01-17T16:50:18Z","_createdAt":"2020-05-04T23:47:20Z","name":"AHA: American Heart Association Scientific Sessions","_type":"documentGroup","pixelTrackingCode":null,"_id":"conference_aha","identifier":{"current":"aha","_type":"slug"},"parent":{"_id":"a0e8a8bf-62dd-45ed-a1e1-cd1e5e8de6f6","parent":null,"identifier":{"current":"conference","_type":"slug"},"_createdAt":"2020-04-03T18:14:34Z","_type":"documentGroup","name":"Conference","pixelTrackingCode":{"_ref":"c42e5374-778f-4c0d-9f48-73dc34bb9008","_type":"reference"},"_rev":"4o2kwjzNDJRdyxUiyQV0Zp","_updatedAt":"2022-07-31T01:49:46Z"},"_rev":"Sik6IfwDKxX0JgkwgBkqto"}],"url":"shaping-the-future-of-cardiology-key-takeaways-from-aha-2024","summary":"Attendees of the centennial American Heart Association (AHA) conference commend the meeting's ability to bring together diverse, interdisciplinary perspectives from across the globe. 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Shaw","url":"maggie-l-shaw"}],"body":[{"videoID":"6365178683112","disableAutoPlayVideo":false,"source":"brightcove","_key":"b6ebabf24ecb","videoObject":{"thumbnail":{"asset":{"_ref":"image-758a0de566362b3ad859754c1250dd77346ec42d-1200x738-jpg","_type":"reference"},"_type":"image"},"videoDuration":"PT3M40S","videoDescription":"Interview with Christopher Sayed, MD, UNC Chapel Hill","_type":"videoDetails","videoTitle":"BE HEARD Trials Highlight Efficacy of Bimekizumab in Hidradenitis Suppurativa"},"_type":"video","caption":"Christopher Sayed, MD, UNC Chapel Hill"},{"_type":"block","style":"normal","_key":"8c64da102cde","markDefs":[],"children":[{"_key":"1668c573481d","_type":"span","marks":[],"text":""}]},{"_key":"afba9b78c4be","markDefs":[{"href":"https://www.ajmc.com/compendium/immunology","_key":"e46ef3fbfbb8","nofollow":false,"blank":true,"_type":"link"}],"children":[{"_type":"span","marks":[],"text":"On November 20, the FDA approved bimekizumab (Bimzelx; UCB Pharma) for use in patients with moderate to severe ","_key":"58309fc001a50"},{"_type":"span","marks":["e46ef3fbfbb8"],"text":"hidradenitis suppurativa","_key":"ddb697553a03"},{"marks":[],"text":".","_key":"74773024ad48","_type":"span"},{"_type":"span","marks":["superscript"],"text":"1","_key":"58309fc001a51"},{"_type":"span","marks":[],"text":" Chris Sayed, MD, dermatologist and a professor at the University of North Carolina at Chapel Hill Department of Dermatology, was an investigator with the BE HEARD I and II trials, which provided the data the FDA used as the basis for this approval.","_key":"58309fc001a52"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"7c26e19987cd0"}],"_type":"block","style":"normal","_key":"1740fcca2476"},{"markDefs":[],"children":[{"_key":"c877d2a8f4b90","_type":"span","marks":[],"text":"This newest approval is the fifth overall for the anti–IL-17A, IL-17F, and IL-17AF humanized immunoglobulin G1 monoclonal antibody, with indications granted for psoriatic arthritis, nonradiographic axial spondyloarthritis, ankylosing spondylitis, and moderate to severe plaque psoriasis since October 2023."},{"_type":"span","marks":["superscript"],"text":"2,3","_key":"140b8b4fa593"}],"_type":"block","style":"normal","_key":"08397953af45"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"1b2a16ad6d620"}],"_type":"block","style":"normal","_key":"ee7ae0b8e1c4"},{"style":"normal","_key":"1d1ef8bbc536","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Here, Sayed delves into how bimekizumab helps to fill treatment gaps for patients living with hidradenitis suppurativa and what the open-label extension trial is seeking to accomplish.","_key":"41c9126fd7470"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"6baab88b4fb10"}],"_type":"block","style":"normal","_key":"9d1b30c172d1"},{"style":"normal","_key":"e280fc59d829","markDefs":[],"children":[{"text":"This transcript has been lightly edited for clarity.","_key":"2525d8b9c5210","_type":"span","marks":["em"]}],"_type":"block"},{"markDefs":[],"children":[{"text":"","_key":"9010d55d52c80","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"b663b7a4f685"},{"markDefs":[],"children":[{"marks":["strong","underline"],"text":"Transcript","_key":"8341a58f4d720","_type":"span"}],"_type":"block","style":"normal","_key":"b843af072ffd"},{"_key":"5da8fe052360","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"cf4fab940e8e0"}],"_type":"block","style":"normal"},{"style":"normal","_key":"fffc3d372d40","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"How does this dual IL-17A/IL-17F inhibitor help to address unmet clinical needs in patients with hidradenitis suppurativa?","_key":"2e8355f1f8f30"}],"_type":"block"},{"_key":"ea665cdc3c35","markDefs":[],"children":[{"text":"","_key":"dc65af14254d0","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"29889b05f1a3","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Bimekizumab is unique to other drugs that are currently on the market because it affects a couple of types of IL-17. There are other IL-17 antagonists that are out there that mostly have tried to go after and block IL-17A, which is very important in conditions like psoriasis and other inflammatory diseases, but there's another type of IL-17 called IL-17F. And while it's not sort of as potent at causing inflammation, there's just so much of it around that if you don't block it, you tend to see continued inflammation in those patients.","_key":"2d4341db6b520"}]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"2f5ca6ff7c770","_type":"span"}],"_type":"block","style":"normal","_key":"5df1beed20c8"},{"style":"normal","_key":"8b18cf35a776","markDefs":[],"children":[{"text":"So by blocking both A and F, you get a more complete blockade of the type of inflammation that drives these kinds of conditions, and in some instances, that seems to translate into improvement in symptoms overall. So, there seems to be increasing efficacy of the IL-17A and F antagonists compared to those that block IL-17A alone. That won't necessarily be across the board, but the overall trend seems to be in that direction.","_key":"0949c74fb0500","_type":"span","marks":[]}],"_type":"block"},{"style":"normal","_key":"cd4d03568a62","markDefs":[],"children":[{"_key":"1e150d91bdfb0","_type":"span","marks":[],"text":""}],"_type":"block"},{"_key":"d7585ae1a3e3","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Can you provide an overview of the BE HEARD I and II trials that provided the data for this approval?","_key":"5e51dc80c9f30"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"728abb2b02220"}],"_type":"block","style":"normal","_key":"eed1cb3b5eb5"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"BE HEARD I [NCT04242446] and BE HEARD II [NCT04242498] are the 2 large trials were designed in pretty much an identical way to try to understand how well we treat HS with something like bimekizumab and also what the safety of that medication is in those patients who have HS.","_key":"cc3bfcbb1eb30"}],"_type":"block","style":"normal","_key":"7d361d2fdc7d"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"16ec4aab01250"}],"_type":"block","style":"normal","_key":"341f95ad3fd3"},{"style":"normal","_key":"f1394ee7b05e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The nice thing is that it showed very good efficacy. It used pretty good methods that are tried and true from other trials to look at how patients responded over time, and in particular, they used a higher benchmark. Most studies have used a 50% reduction in inflammatory lesions as a rough estimate of how well patients are doing. This study looked at 75% reduction. So it set a higher bar and showed that many patients hit that standard, and it clearly differentiated itself from a placebo—so control where there was no active treatment being used at all.","_key":"2013b29a53e40"}],"_type":"block"},{"_key":"f51625278967","markDefs":[],"children":[{"marks":[],"text":"","_key":"422d1c2e031d0","_type":"span"}],"_type":"block","style":"normal"},{"children":[{"text":"I think the most important thing that I get out of these studies is that it looks like things continued to improve or at least remain stable for those patients over a long period of time. So more than just 16 weeks, over the course of a year and 2 years, you saw that there was continued improvement throughout the course for many of those patients. And so many stayed in the trial for 2 years despite the fact they're having to go back so often, and it's such a burden to be in a trial. That shows me that just a lot of patients see these really deep responses. That's what's important—not these partial responses, but when patients feel like they really had a major disease reduction or maybe even feel like relatively clear as time has passed.","_key":"ca828791ed890","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"5c7581e4dc27","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"","_key":"a5591330c10c0"}],"_type":"block","style":"normal","_key":"ae0ea1c2b13d","markDefs":[]},{"style":"normal","_key":"c0c31a19c631","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Can you discuss the open-label extension study evaluating bimekizumab in patients previously enrolled in BE HEARD I and II?","_key":"fbbe93698d250"}],"_type":"block"},{"style":"normal","_key":"0b2690765768","markDefs":[],"children":[{"_key":"46de224437150","_type":"span","marks":[],"text":""}],"_type":"block"},{"style":"normal","_key":"dc00ba9a6178","markDefs":[],"children":[{"text":"An open label extension is always a great opportunity to understand how well a drug works as more time passes and to make sure that it remains safe as more time passes. 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