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/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F11ee9be36fc4be88ca66a17e7b37ebc45bb91d87-6048x4024.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F11ee9be36fc4be88ca66a17e7b37ebc45bb91d87-6048x4024.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F11ee9be36fc4be88ca66a17e7b37ebc45bb91d87-6048x4024.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F11ee9be36fc4be88ca66a17e7b37ebc45bb91d87-6048x4024.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F11ee9be36fc4be88ca66a17e7b37ebc45bb91d87-6048x4024.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F11ee9be36fc4be88ca66a17e7b37ebc45bb91d87-6048x4024.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="object-contain" loading="lazy"/></noscript></span></a></div><div class="border-t-gray-100 border-t-2 flex-auto py-2 "><span class="text-sm text-gray-500 py-2">February 13th 2025</span><div class="py-3"><a class="lg:text-[20px] text-[19px] font-[500]" href="/view/rapid-iv-isatuximab-could-shift-care-practices-in-mm">Rapid IV Isatuximab Could Shift Care Practices in MM</a></div><div class="pb-2"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/kyle-munz"><i>Kyle Munz</i></a></span></div></div><a href="/view/rapid-iv-isatuximab-could-shift-care-practices-in-mm"><a href="/view/rapid-iv-isatuximab-could-shift-care-practices-in-mm"><p class="mt-1 text-gray-800 text-[13px] line-clamp-6 text-hidden">Reducing intravenous (IV) isatuximab delivery from 75 minutes to 30 minutes could provide a wealth of benefits to patients with multiple myeloma (MM) and health care systems alike. </p></a></a></div></div><div class="flex-wrap w-[60%] flex "><a class="flex w-[50%] flex-col sm:pl-[35px] pl-[20px] pb-[35px] " href="/view/fda-approves-brentuximab-vedotin-lenalidomide-rituximab-triplet-for-r-r-lbcl"><div class="w-full lg:h-[134px] h-[100px] relative bg-default-logo-background "><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" 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style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="lg:object-cover object-contain " loading="lazy"/></noscript></span></div><div class="border-t-gray-100 border-t-2 pt-2 pb-2 flex-auto "><a href="/view/fda-approves-brentuximab-vedotin-lenalidomide-rituximab-triplet-for-r-r-lbcl"><span class="text-sm text-gray-500">February 12th 2025</span></a><div><a class="text-[14px]" href="/view/fda-approves-brentuximab-vedotin-lenalidomide-rituximab-triplet-for-r-r-lbcl"><p class="line-clamp-4 text-hidden font-[500]">FDA Approves Brentuximab Vedotin, Lenalidomide, Rituximab Triplet for R/R LBCL</p></a></div><div class="py-2"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/maggie-l-shaw"><i>Maggie L. 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Klein</i></a></span></div></div></div></a><a class="flex w-[50%] flex-col sm:pl-[35px] pl-[20px] pb-[35px] " href="/view/refining-remission-assessment-in-aggressive-b-cell-lymphomas"><div class="w-full lg:h-[134px] h-[100px] relative bg-default-logo-background "><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="lg:object-cover object-contain " style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F45ebaec8c26ad90ca651cff0ef77c13a93fd2caa-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F45ebaec8c26ad90ca651cff0ef77c13a93fd2caa-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F45ebaec8c26ad90ca651cff0ef77c13a93fd2caa-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F45ebaec8c26ad90ca651cff0ef77c13a93fd2caa-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F45ebaec8c26ad90ca651cff0ef77c13a93fd2caa-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F45ebaec8c26ad90ca651cff0ef77c13a93fd2caa-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F45ebaec8c26ad90ca651cff0ef77c13a93fd2caa-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F45ebaec8c26ad90ca651cff0ef77c13a93fd2caa-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F45ebaec8c26ad90ca651cff0ef77c13a93fd2caa-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="lg:object-cover object-contain " loading="lazy"/></noscript></span></div><div class="border-t-gray-100 border-t-2 pt-2 pb-2 flex-auto "><a href="/view/refining-remission-assessment-in-aggressive-b-cell-lymphomas"><span class="text-sm text-gray-500">February 7th 2025</span></a><div><a class="text-[14px]" href="/view/refining-remission-assessment-in-aggressive-b-cell-lymphomas"><p class="line-clamp-4 text-hidden font-[500]">Refining Remission Assessment in Aggressive B-Cell Lymphomas</p></a></div><div class="py-2"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/maggie-l-shaw"><i>Maggie L. 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style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="object-cover" loading="lazy"/></noscript></span></div><div class="jsx-2785488040 content-wrap"><span class="jsx-2785488040 py-3 text-sm text-gray-500 text-left"><i class="jsx-2785488040">December 14th 2017</i></span><div class="jsx-2785488040 w-full h-fit mb-4"><p class="jsx-2785488040 text-[18px] font-bold text-[#000000] text-left line-clamp-3 text-hidden">Five Years of Reducing Overuse of Medical Services With Choosing Wisely</p></div></div></div></a></div></div></div><div class="flex items-center space-x-4 border-0 border-b border-secondary select-none py-1"><h2 class="text-3xl text-primary">More News</h2></div><div class="flex flex-wrap w-full pb-4"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/synkir-310-dosing-for-b-nhl-begins-in-celestial-301-trial"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f272659f901b7e489abfdd17374a9392ea72cf6d-1200x738.jpg?fit=crop&auto=format" alt="Non-HodgkinLymphoma | Image Credit: © enterlinedesign-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 30th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/synkir-310-dosing-for-b-nhl-begins-in-celestial-301-trial">SynKIR-310 Dosing for B-NHL Begins in CELESTIAL-301 Trial</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jordyn-sava">Jordyn Sava</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/synkir-310-dosing-for-b-nhl-begins-in-celestial-301-trial"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The CELESTIAL-301 trial evaluating SynKIR-310, a novel chimeric antigen receptor T-cell therapy, has dosed its first patient with relapsed/refractory B-cell non-Hodgkin lymphoma (B-NHL). </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-expands-knowledge-of-prognostic-markers-in-extranodal-nhl"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/243dd302943a41afe5d9b414bc4ec95271932db5-5696x3145.jpg?fit=crop&auto=format" alt="Extranodal NHL is not uncommon, comprising over 30% of NHL cases | image credit: Prostock Studio - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 29th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-expands-knowledge-of-prognostic-markers-in-extranodal-nhl">Study Expands Knowledge of Prognostic Markers in Extranodal NHL</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-expands-knowledge-of-prognostic-markers-in-extranodal-nhl"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Extranodal non-Hodgkin lymphoma (NHL) makes up over one-third of NHL cases, yet remains understudied and in need of deeper research considerations. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/mri-sil-2r-combination-showcases-great-diagnostic-accuracy-for-soft-tissue-nhl"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/75c8bd3f2fb0eb74fdf444d0e10dc7cd0f58ed8a-5500x3667.jpg?fit=crop&auto=format" alt="There remains a need for more diagnostic accuracy in cases of soft tissue NHL | image credit: phonlamaiphoto - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 27th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/mri-sil-2r-combination-showcases-great-diagnostic-accuracy-for-soft-tissue-nhl">MRI, sIL-2R Combination Showcases Great Diagnostic Accuracy for Soft Tissue NHL</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/mri-sil-2r-combination-showcases-great-diagnostic-accuracy-for-soft-tissue-nhl"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Serum soluble interleukin-2 receptor (sIL-2R) levels have been a great diagnostic tool for non-Hodgkin lymphoma (NHL) and could provide further benefits for distinguishing soft-tissue NHL from other soft tissue tumors. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/dr-kirollos-hanna-an-argument-for-outpatient-bispecific-antibody-delivery"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f698018f94ae99ba6f548f81a15462f47765951b-1280x720.png?fit=crop&auto=format" alt="Kirollos Hanna, PharmD" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 25th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/dr-kirollos-hanna-an-argument-for-outpatient-bispecific-antibody-delivery">An Argument for Outpatient Bispecific Antibody Delivery: Dr Kirollos Hanna</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kirollow-hanna-pharmd">Kirollos Hanna, PharmD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/dr-kirollos-hanna-an-argument-for-outpatient-bispecific-antibody-delivery"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Bispecific antibodies have altered the multiple myeloma (MM) treatment landscape, but some practices still lack enough familiarity with these therapeutics to deliver them in outpatient settings. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/treosulfan-regimen-approved-for-allohsct-conditioning-in-aml-mds"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b0002ea79080e3493345e3c993b00be4690f0087-4279x2706.jpg?fit=crop&auto=format" alt="FDA approved. | Image Credit: Pawel - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 23rd 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/treosulfan-regimen-approved-for-allohsct-conditioning-in-aml-mds">Treosulfan Regimen Approved for Allo-HSCT Conditioning in AML/MDS</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/treosulfan-regimen-approved-for-allohsct-conditioning-in-aml-mds"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA approved treosulfan in combination with fludarabine as preparation for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in adult and pediatric patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/high-infection-risk-in-mm-insights-from-the-pre-immunotherapy-era"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/7286b9eed868f8255bff55121b38c06742c21073-4032x2688.jpg?fit=crop&auto=format" alt="Infection risk concept; floating bacterial particles | image credit: ChaoticMind - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 21st 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/high-infection-risk-in-mm-insights-from-the-pre-immunotherapy-era">High Infection Risk in MM: Insights From the Preimmunotherapy Era</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/high-infection-risk-in-mm-insights-from-the-pre-immunotherapy-era"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Infection risk remains a prominent clinical concern for patients with multiple myeloma (MM), even with the advent of modern, novel therapies. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-7"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/unmet-needs-remain-in-secondary-aml-following-treatment-with-hmas"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b116cf9c3a9e75563fb56ccc1285d045d7c89884-7168x4096.jpg?fit=crop&auto=format" alt="First-line treatment for MDS often includes hypomethylating agents, so it is common for patients with sAML to have prior exposure to these agents. - Eleni - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 18th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/unmet-needs-remain-in-secondary-aml-following-treatment-with-hmas">Unmet Needs Remain in Secondary AML Following Treatment With HMAs</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/unmet-needs-remain-in-secondary-aml-following-treatment-with-hmas"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The study demonstrated a poor prognosis overall for patients with acute myeloid leukemia (AML) who were previously treated with hypomethylating agents (HMAs) for myeloid neoplasms such as myelodysplastic syndromes.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/5-medications-that-defer-blood-donation"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9bcc1340dbb7b42ff0db2829a0a64bf7c38d86d1-6720x4480.jpg?fit=crop&auto=format" alt="Man donating blood | Image Credit: © New Africa - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 17th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/5-medications-that-defer-blood-donation">5 Medications That Defer Blood Donation</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/5-medications-that-defer-blood-donation"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Experts stress that persons wanting to donate blood should not stop any medications they are on, with some deferrals being permanent and others temporary.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/mrd-negativity-a-robust-predictor-of-survival-outcomes-in-mm"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a60f150e189372245ee049cd9c2e6415ca9d36dd-4368x2448.jpg?fit=crop&auto=format" alt="MRD status cannot be detected with a microscope and is achieved through bone marrow analysis | image credit: Arthur Constantine - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 13th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/mrd-negativity-a-robust-predictor-of-survival-outcomes-in-mm">MRD Negativity: A "Robust" Predictor of Survival Outcomes in MM</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/mrd-negativity-a-robust-predictor-of-survival-outcomes-in-mm"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">This meta-analysis sheds more light on the beneficial impact of multiple melanoma (MM) treatments and the predictive value of minimal residual disease (MRD) status for patient prognoses. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/5-things-to-know-about-donating-blood"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e5a5552a5e72c687c6f8880b846e2ba5509ce368-5478x3652.jpg?fit=crop&auto=format" alt="Donating blood can save more than 1 life | image credit: Creative Cat Studio - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 10th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/5-things-to-know-about-donating-blood">5 Things to Know About Donating Blood</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/5-things-to-know-about-donating-blood"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Here are 5 things individuals should know about the powerful impact of blood donation and the benefits becoming a donor can have for patients in need. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-advocates-immunological-value-of-covid-vaccination-in-mm"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4ec4991c20fca48bd4a94346024fe8978ca29f9b-5496x3664.jpg?fit=crop&auto=format" alt="mRNA vaccines can boost T cell responses | image credit: myskin - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 9th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-advocates-immunological-value-of-covid-vaccination-in-mm">Study Advocates Immunological Value of COVID-19 Vaccination in MM</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-advocates-immunological-value-of-covid-vaccination-in-mm"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients with multiple myeloma (MM) can experience diminished immune responses during prolonged treatment; however, mRNA vaccines could bolster immunity in this vulnerable population. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/mrd-status-prior-to-allo-hsct-shows-strong-prognostic-value-in-aml-mds"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e83905430236d6800bb84d2a61fb00c3bf27af05-1037x673.jpg?fit=crop&auto=format" alt="MRD ahead of allo-HSCT showed prognostic value in patients with AML and MDS. | Image credit: keetazalay - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 6th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/mrd-status-prior-to-allo-hsct-shows-strong-prognostic-value-in-aml-mds">MRD Status Prior to Allo-HSCT Shows Strong Prognostic Value in AML, MDS</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kimberly-rath-pharmd">Kimberly Rath, PharmD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/mrd-status-prior-to-allo-hsct-shows-strong-prognostic-value-in-aml-mds"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A study demonstrated that pre-transplant measurable residual disease (MRD) status is a strong prognostic factor for overall survival, disease-free survival, and relapse risk in patients with AML and MDS undergoing allogeneic stem cell transplantation. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-13"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/functional-precision-medicine-tool-targets-personalized-combination-treatment-for-aml"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/1125bb953449f4d178833c3ab84f305fe3883cb7-5376x3584.jpg?fit=crop&auto=format" alt="Among 55 evaluable samples analyzed, QPOP achieved an 87.3% success rate in generating individualized drug sensitivity reports. | Image credit: Eleni - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 6th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/functional-precision-medicine-tool-targets-personalized-combination-treatment-for-aml">Functional Precision Medicine Tool Predicts Treatment Response in AML </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kimberly-rath-pharmd">Kimberly Rath, PharmD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/functional-precision-medicine-tool-targets-personalized-combination-treatment-for-aml"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A new study evaluating the quadratic phenotypic optimization platform shows it can accurately predict personalized drug combination sensitivities, paving the way for improved treatment strategies and outcomes in acute myeloid leukemia (AML). </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/icymi-highlights-from-ash-2024"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3474531227ec6ae0ecdb2a913a4204946efd75a5-3187x1625.png?fit=crop&auto=format" alt="ASH thumbnail" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/icymi-highlights-from-ash-2024">ICYMI: Highlights From ASH 2024</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/icymi-highlights-from-ash-2024"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The 66th American Society of Hematology (ASH) Annual Meeting & Exposition took place December 7-10, 2024, in San Diego, California; the 2025 meeting is currently scheduled to take place in Orlando, Florida, December 6-9.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/top-5-multiple-myeloma-content-of-2024"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ef6f1663f0b22e324047ab01ad49bda91c402dd8-3187x1625.png?fit=crop&auto=format" alt="MM Top 5 Thumbnail" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/top-5-multiple-myeloma-content-of-2024">Top 5 Multiple Myeloma Content of 2024</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/top-5-multiple-myeloma-content-of-2024"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Through interviews and articles infused with expert insight, progress against this cancer that develops in the bone marrow was showcased. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/infection-rate-more-than-double-in-cll-sll-accompanied-by-secondary-immunodeficiency-disease"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f0c5d4ea0717f266f567a6a19f049cf7ff272c85-7500x4076.jpg?fit=crop&auto=format" alt="A subpopulation of patients with CLL/SLL and secondary immunodeficiency disease carry increased infection risks | image credit: sdecoret - stock.adobe.com " width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 19th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/infection-rate-more-than-double-in-cll-sll-accompanied-by-secondary-immunodeficiency-disease">Infection Rate More Than Doubles in CLL/SLL Accompanied by Secondary Immunodeficiency Disease</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/infection-rate-more-than-double-in-cll-sll-accompanied-by-secondary-immunodeficiency-disease"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Secondary immunodeficiency disease (SID) status was associated with significantly higher risk for severe bacterial infections in adult patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/canadian-study-highlights-care-variability-for-older-patients-with-mds-aml"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/09ac6e6547157d8cf7aea4ba82ef74b908ab1b2a-3254x1424.jpg?fit=crop&auto=format" alt="Older patients with AML or MDS do not always receive the same care recommendations, a study found | image credit: Orawan - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 19th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/canadian-study-highlights-care-variability-for-older-patients-with-mds-aml">Canadian Study Highlights Care Variability for Older Patients With MDS/AML </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kimberly-rath-pharmd">Kimberly Rath, PharmD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/canadian-study-highlights-care-variability-for-older-patients-with-mds-aml"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A national survey of Canadian hematologists reveals gaps and variability in supportive care strategies for older adults with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), emphasizing the need for evidence-based guidelines. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/luspatercept-promising-against-anemia-in-mds"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/19a045e807adb6aef69a3b7433a41f0aa981e96f-1200x738.jpg?fit=crop&auto=format" alt="MDS graphic | Image Credit: © Sviatlana-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 18th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/luspatercept-promising-against-anemia-in-mds">Luspatercept Promising Against Anemia in MDS</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kimberly-rath-pharmd">Kimberly Rath, PharmD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/luspatercept-promising-against-anemia-in-mds"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Findings from a phase 2 trial show that luspatercept effectively improves anemia in patients with lower-risk myelodysplastic syndromes (MDS), enabling them to delay or prevent transfusion dependence while maintaining a favorable safety profile.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-19"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/icymi-highlights-from-ims-2024"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/113dcf7dd1ba47890eba652e443c1fa23a50ac28-3187x1625.png?fit=crop&auto=format" alt="ICYMI: Highlights From IMS 2024 " width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 17th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/icymi-highlights-from-ims-2024">ICYMI: Highlights From IMS 2024 </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/icymi-highlights-from-ims-2024"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The expert knowledge presented at this year’s International Myeloma Society (IMS) annual meeting focused on minimal residual disease testing and status, defining and treating high-risk disease, CEPHEUS trial findings, and an investigational off-the-shelf chimeric antigen receptor T-cell therapy.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/molecular-lesions-in-low-risk-myelodysplastic-neoplasms-disrupt-prognostic-model-for-leukemia"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/32c22e9f8583388f1198520ca9a98f3cf9ff8c6f-1107x738.jpg?fit=crop&auto=format" alt="MDS | Image Credit: © ibreakstock-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 11th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/molecular-lesions-in-low-risk-myelodysplastic-neoplasms-disrupt-prognostic-model-for-leukemia">Molecular Lesions in Low-Risk Myelodysplastic Neoplasms Disrupt Prognostic Model for Leukemia</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/molecular-lesions-in-low-risk-myelodysplastic-neoplasms-disrupt-prognostic-model-for-leukemia"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Conventional parameters for risk stratification prognosis for patients with low-risk myelodysplastic neoplasms, especially bone marrow blast percentage, drop their clinical significance once molecular lesions are included in prognostic scores.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/6-year-data-support-fixed-duration-ven-obi-for-untreated-cll"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/8b532ed92234b55d19339ba1cd96b319212188cf-6000x4000.jpg?fit=crop&auto=format" alt="CLL cells magnified/stained | image credit: jarun011 - stock.adobe.com " width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 10th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/6-year-data-support-fixed-duration-ven-obi-for-untreated-cll">6-Year Data Support Fixed-Duration Ven-Obi for Untreated CLL </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jared-kaltwasser">Jared Kaltwasser</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/6-year-data-support-fixed-duration-ven-obi-for-untreated-cll"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Long-term data support the safety and efficacy of venetoclax (Venclexta) and obinutuzumab (Gazyva) in chronic lymphocytic leukemia (CLL), though questions remain about which patients would benefit most from the regimen. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/tattoos-may-be-associated-with-increased-risk-of-rare-nhls"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/d68a0ae1f89cececa803c05ff5632ab318098f1c-5472x3648.jpg?fit=crop&auto=format" alt="New evidence suggest a slight connection between receiving a tattoo and elevated cancer risks | image credit: xartproduction - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/tattoos-may-be-associated-with-increased-risk-of-rare-nhls">Tattoos May Be Associated With Increased Risk of Rare NHLs </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-contributor">AJMC Contributor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/tattoos-may-be-associated-with-increased-risk-of-rare-nhls"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Despite found associations, due to small sample sizes the researchers suggest readers interpret their findings with caution. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f1f12e9d502c73f75e8062c6dd726c422c8aff78-4320x3473.jpg?fit=crop&auto=format" alt="FDA Approval | image credit: gomixer - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers">FDA Approves Imatinib Oral Solution for Treatment of Various Cancers</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA approval marks the first oral solution indicated for patients with different forms of leukemia. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/nccn-guidelines-prioritize-quad-therapy-in-multiple-myeloma"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/124e5227038c54b0c2ef35d60292e6f37e89161a-1200x738.jpg?fit=crop&auto=format" alt="Guidelines | Image Credit: © momius-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/nccn-guidelines-prioritize-quad-therapy-in-multiple-myeloma">NCCN Guidelines Prioritize Quad Therapy in Multiple Myeloma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/nccn-guidelines-prioritize-quad-therapy-in-multiple-myeloma"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In the most recent update to the National Comprehensive Cancer Network (NCCN) guidelines for treating patients who have multiple myeloma, a quadruplet regimen became the preferred first-line treatment option for transplant-eligible and -ineligible patients.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-25"></div></div></div><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/progression-free-survival-in-relapsed-multiple-myeloma-extended-with-consolidation-and-maintenance-therapy-with-ixazomib"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e8b89f6523b42f0e4eac2c396f686ac915160fbf-1200x738.jpg?fit=crop&auto=format" alt="Clinical trial results-Egor-stock.adobe.com.jpeg" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/progression-free-survival-in-relapsed-multiple-myeloma-extended-with-consolidation-and-maintenance-therapy-with-ixazomib">Progression-Free Survival in Relapsed Multiple Myeloma Extended With Ixazomib, Data Show</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/giuliana-grossi">Giuliana Grossi</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/progression-free-survival-in-relapsed-multiple-myeloma-extended-with-consolidation-and-maintenance-therapy-with-ixazomib"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Despite challenges such as high attrition rates and adverse events, the trial highlights the value of established therapies in improving outcomes, particularly in regions with limited access to chimeric antigen receptor T cells and bispecific antibodies.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/real-world-data-confirm-ibrutinib-s-role-in-relapsed-cll"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/fd617092164d84c81add47518d2c67d8dc91de53-1200x738.jpg?fit=crop&auto=format" alt="Big Data | Image Credit: © Friends Stock-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/real-world-data-confirm-ibrutinib-s-role-in-relapsed-cll">Real-World Data Confirm Ibrutinib's Role in Relapsed CLL</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/gayle-turim-dickstein">Gayle Turim Dickstein</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/real-world-data-confirm-ibrutinib-s-role-in-relapsed-cll"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">This multiyear follow-up of more than 3300 patients with relapsed/refractory chronic lymphocytic leukemia (R/R CLL) who received ibrutinib—the longest study of its kind—confirms the agent’s efficacy as a salvage treatment but reveals new information about its impact in different subpopulations with varying clinical characteristics.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/balancing-life-and-myeloma-a-patient-centered-approach"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6c4eacfe9c992d1f7ea48bbb7606ade7b9a0b9cf-1920x1080.jpg?fit=crop&auto=format" alt="Don M. Benson, MD, PhD, James Cancer Hospital" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 22nd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/balancing-life-and-myeloma-a-patient-centered-approach">Balancing Life and Myeloma: A Patient-Centered Approach</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/balancing-life-and-myeloma-a-patient-centered-approach"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In this second part of our discussion with Don M. Benson, MD, PhD, from our recent Institute for Value-Based Medicine® event in Cleveland, Ohio, he explains how his ultimate goal for his patients is for them to live as long and as well as possible.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/elevating-value-in-cancer-care-with-innovations-accessibility-equity"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/c93bf646d31467af3bf1146ded1ddb1b32755d08-2022x645.png?fit=crop&auto=format" alt="Elevating Value in Cancer Care With Innovations, Accessibility, Equity" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 21st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/elevating-value-in-cancer-care-with-innovations-accessibility-equity">Elevating Value in Cancer Care With Innovations, Accessibility, Equity</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/elevating-value-in-cancer-care-with-innovations-accessibility-equity"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Coverage from the IVBM Regional event in Denver, Colorado.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-reveals-leukemia-transplant-successes-and-persistent-relapse-risks"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4a82f1a2b2140eb1b1fdd01a6b1e2ebd5299dc00-8064x5376.jpg?fit=crop&auto=format" alt="AML cells concept | image credit: sovova - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 21st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-reveals-leukemia-transplant-successes-and-persistent-relapse-risks">Study Reveals Leukemia Transplant Successes and Persistent Relapse Risks </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kimberly-rath-pharmd">Kimberly Rath, PharmD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-reveals-leukemia-transplant-successes-and-persistent-relapse-risks"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Long-term survival rates for patients with leukemia after hematopoietic cell transplantation (HCT) are encouraging but personalized transplant strategies remain important to improve outcomes. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/os-better-with-belantamab-mafodotin-triplet-vs-daratumumab-in-r-r-mm"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/80e6c85b19f91f7e54b4708b48cf74f795adc108-1200x738.jpg?fit=crop&auto=format" alt="Multiple Myeloma | Image Credit: © Dzmitry-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 19th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/os-better-with-belantamab-mafodotin-triplet-vs-daratumumab-in-r-r-mm">OS Better With Belantamab Mafodotin Triplet vs Daratumumab in R/R MM</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jordyn-sava">Jordyn Sava</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/os-better-with-belantamab-mafodotin-triplet-vs-daratumumab-in-r-r-mm"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The key secondary end point of overall survival (OS) was met in the DREAMM-7 trial of belantamab mafodotin (Blenrep; GSK) for the treatment of patients with relapsed/refractory multiple myeloma (R/R MM).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div><div class="w-full text-center flex justify-center pb-24"><a class="px-4 py-2 border-y border-r bg-primary text-white" href="/compendium/hematology?page=1">1</a><a class="px-4 py-2 border-y border-r " href="/compendium/hematology?page=2">2</a><a class="px-4 py-2 border-y border-r " href="/compendium/hematology?page=3">3</a><a class="px-4 py-2 border-y border-r " href="/compendium/hematology?page=4">4</a><a class="px-4 py-2 border-y border-r " href="/compendium/hematology?page=5">5</a><a class="px-4 py-2 border-y border-r " href="/compendium/hematology?page=6">6</a><a class="px-4 py-2 border-y border-r " href="/compendium/hematology?page=7">7</a><a class="px-4 py-2 border-y border-r " href="/compendium/hematology?page=8">8</a><div class="px-4 py-2 border-y border-r">...</div><a class="px-4 py-2 border-y border-r" href="/compendium/hematology?page=25">25</a><a class="px-4 py-2 border-y border-r" href="/compendium/hematology?page=2">></a></div></div></div><div class="flex-none w-[300px] z-[9999] relative hidden md:block"><div style="top:5rem" class="sticky custom-spacing"><div class="collapse-container " style="overflow:hidden;max-height:900px;transition:max-height .4s ease-in-out"></div></div></div></div><div id="div-gpt-ad-pixel" style="width:1px;height:1px" class=""></div><noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NK5KQXS" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript><div id="footerOuterWrap" class=" mx-auto 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Mikkael A. Sekeres, MD, chief of the Division of Hematology at Sylvester Comprehensive Cancer Center, University of Miami, and chair of the American Society of Hematology Committee on Communications, spoke to the potential benefits of treosulfan vs busulfan for patients with AML or MDS undergoing allo-HSCT. 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I'm a nontransplant leukemia doctor or MDS doctor, so I don't use these agents myself. I do make the decision of whether or not to refer a patient to a transplanter. You can think of me as almost being like a gatekeeper, or, as I say to my patients, I don't have any dogs in this fight. If I refer a patient to a transplanter, it's with a pure heart. 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Graft-vs-host disease rates within the first 6 months were ","_key":"d4277b1d41a4","_type":"span"},{"text":"8% for those who got busulfan vs 5% for those who got treosulfan","_key":"ae735b8799aa","_type":"span","marks":["932aaaa216bc"]},{"_type":"span","marks":[],"text":". There was some nominal cardiac toxicity—a little bit higher with busulfan at 2% vs less than 1% for those patients who got treosulfan. Patients did get infections—13% for those who got busulfan vs 9% for those who got treosulfan—but they really don't seem to be out of line for either of these agents in this very high-risk population.","_key":"dcd4b754f77d"}]},{"_key":"e1d1140b00b4","markDefs":[],"children":[{"marks":[],"text":"","_key":"e8722d38d6ba","_type":"span"}],"_type":"block","style":"normal"},{"style":"normal","_key":"1ee3ca398e1e","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Is there anything else you would like to add regarding the approval of treosulfan for AML/MDS allo-HSCT conditioning?","_key":"ba90a7d87469"}],"_type":"block"},{"_key":"becbe40e5c62","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"a0581743dad1"}],"_type":"block","style":"normal"},{"children":[{"marks":[],"text":"One more comment I would make is it's really neat to see the FDA approving conditioning regimens for hematopoietic cell transplantation. Transplantation is tricky and it's complicated. I've actually approached members of FDA before to assess whether they would be open to having transplantation as an efficacy end point for treatments for myelodysplastic syndrome or leukemia. In other words, if a patient makes it to transplantation, that's the outcome of interest, that's the success. What they reflected back to me is transplantation is too tricky. There are too many things that can go in weird directions that would affect that efficacy end point. It would depend on the quality of matches, how quickly a patient could identify a match, whether a patient had other events from the prior treatment for leukemia or myelodysplastic syndrome to affect that outcome, and then how a patient did following that transplant. 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Mikkael A. Sekeres, MD, chief of the Division of Hematology at Sylvester Comprehensive Cancer Center, University of Miami, and chair of the American Society of Hematology (ASH) Committee on Communications, discussed data supporting the use of treosulfan as part of conditioning for allo-HSCT. 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Now to back up for a second, I practice leukemia and treat people who have acute myeloid leukemia and myelodysplastic syndromes. For somebody with MDS—myelodysplastic syndromes—we refer them for transplantation when they have higher risk disease at diagnosis, and for those with lower risk MDS, we wait until patients have gone through all their available therapies and have started to increase their transfusion needs, and then we recommend that they undergo transplantation. For MDS, bone marrow transplantation, or hematopoietic cell transplantation, is the only curative option we have.","_key":"63593e4de3e7"}]},{"_type":"block","style":"normal","_key":"eab7f91ffc15","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"f1db9c11314a"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"For patients with acute myeloid leukemia, our approach is a little bit different. We tend to divide them into risk groups, probably most commonly, you're using the European LeukemiaNet classification, into patients who have a favorable prognosis, intermediate, or poor risk prognosis. For those who have a poor risk prognosis with acute myeloid leukemia—and you can imagine, these are folks who have poor risk molecular mutations or karyotypic abnormalities—we refer them for transplantation in first complete remission, so we try to get them into remission with chemotherapy and then refer them immediately to transplantation. We think that's their best chance of cure. For patients with favorable risk acute myeloid leukemia, we generally don't transplant these folks up front because their outcomes with chemotherapy alone are pretty good. For those who fall into the middle category, it's a little bit of a dealer's choice. 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One was a non-inferiority end point, meaning treosulfan didn't appear to be statistically worse than busulfan, but it also met an improved overall survival end point.","_key":"ed9f736269ae"}],"_type":"block"},{"style":"normal","_key":"d2eef1e8e242","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"5570df19ad40"}],"_type":"block"},{"markDefs":[],"children":[{"text":"Now, transplanters will quickly pivot and say, “Okay, well, that's great, but what about relapse risk and what about graft-vs-host disease?” So, the relapse-free survival was about the same between these 2 groups, and the rates of graft-vs-host disease within the first 6 months and thereafter were about the same between these two groups. 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It's striking, because at diagnosis, their number 1 goal—in this paper anyway—was overall survival. Nothing else mattered. And in the relapse/refractory setting, the number 1 goal, by far and away, was survival. The reason it's such an interesting paper is that that middle, that in-between, when the disease is in remission, it's all about quality of life. It's energy, fatigue, pain, cognitive function, independence, freedom. Those metrics take on substantially more meaning and importance for patients overall and beyond survival."}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"","_key":"2c11316f10510"}],"_type":"block","style":"normal","_key":"b3547bc19325","markDefs":[]},{"_key":"2c54f82fe451","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Myeloma is not a sprint, it's a marathon. And I think as physicians, as specialists, we need to be sensitive to where patients are in the journey. When somebody is newly diagnosed, their risk tolerance is very different than when their disease is in remission and you're trying to cajole them into taking a maintenance pill that might cause diarrhea or it might cause a rash. This is what I mean by taking into account patients' desires and goals.","_key":"9c2dc2e2f59f0"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"9c6eae269a0d0"}],"_type":"block","style":"normal","_key":"0519421b2b46"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"I'll give you another example. We had a patient last year who was diagnosed in the early part of the year, got induction treatment, got into remission, we collected his stem cells, and then his daughter got engaged. And she wanted to get married while dad was well. The wedding was in October, and he came in and said, “I want to walk my daughter down the aisle with a full head of hair and I want to dance at her reception with a full head of hair.” And so we delayed his transplant.","_key":"ba83c7a6b4cb0"}],"_type":"block","style":"normal","_key":"4cab7ee5b2bf"},{"style":"normal","_key":"437d3974a0b5","markDefs":[],"children":[{"text":"","_key":"67ca22e152540","_type":"span","marks":[]}],"_type":"block"},{"_type":"block","style":"normal","_key":"5ecbc0dc03fc","markDefs":[],"children":[{"marks":[],"text":"That's sort of what I mean by tailoring treatment to individuals. And he's doing great, by the way; he got a transplant, he's killing it, he's doing awesome.","_key":"7a55dcf4d9110","_type":"span"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"0bab6b7347800"}],"_type":"block","style":"normal","_key":"00a2d1dfc181"},{"markDefs":[],"children":[{"_key":"daaf359a649e0","_type":"span","marks":[],"text":"I can tell you with great confidence that I've taken so much more from my patients than I could ever give them. When you're confronted with your mortality and being told you have an incurable cancer, I'm truly humbled to walk into… I hesitate to even call it "},{"_type":"span","marks":["em"],"text":"work","_key":"daaf359a649e1"},{"text":". It's just a privilege to come in and be with these people. And in some way, if I can help them, that's great. 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I think one of the most important ones has been the addition of the anti–CD-38 monoclonal antibodies, and adding them to the backbone of RBD [lenalidomide (Revlimid), bortezomib, and dexamethasone] or KRD [carfilzomib (Kyprolis), lenalidomide, and dexamethason] previous treatments. With those [as] induction chemotherapy, we've had the greatest responses that we've ever seen in multiple myeloma. So I think that has certainly affected the outcome in terms of response rates, progression-free survival, and hopefully overall survival in the future. We're excited to see that. Additionally, cell therapies and bispecifics are very interesting therapies. So we're excited to see myeloma [treatments] moving there as well.","_key":"280466ff607e0"}]},{"_type":"block","style":"normal","_key":"a1eaeb9b1b92","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"","_key":"34db0c36d057"}]},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"How do you approach the challenge of balancing cost-effectiveness with clinical effectiveness when incorporating novel therapies like CAR T and bispecific antibodies into multiple myeloma care?","_key":"e145ab661d3b0"}],"_type":"block","style":"normal","_key":"61201454f0bf"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"fa6d961b679e"}],"_type":"block","style":"normal","_key":"e941fa925dcf"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"That's a great question. [With] all of our therapies, the better they get, the more expensive they get. So that's a challenge, and it's a challenge for our system. 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clarity.","_key":"89dee18d3f31"}],"_type":"block","style":"normal","_key":"cd5353fbd065"},{"markDefs":[],"children":[{"_type":"span","marks":["em"],"text":"","_key":"b6ae712ff75c"}],"_type":"block","style":"normal","_key":"ddfb9c23fa8d"},{"_key":"cc7f86a962e8","markDefs":[],"children":[{"_type":"span","marks":["underline","strong"],"text":"Transcript","_key":"95b401fddc05"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"marks":["strong"],"text":"\nWhat role does patient education play in managing expectations and outcomes, especially with the increased use of innovative but complex therapies?","_key":"8c500e2ff26b0","_type":"span"}],"_type":"block","style":"normal","_key":"a7cbd86c3c45"},{"markDefs":[],"children":[{"text":"","_key":"0c5d1f5dd791","_type":"span","marks":["strong"]}],"_type":"block","style":"normal","_key":"0c309c01d5ac"},{"style":"normal","_key":"bb5cef088d35","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Education is crucial in terms of supportive care. I'm from the transplant world, so that's where we really need to make sure the patient has a caregiver or has someone who can help them navigate the system and help them with the chores. Usually with our patient population that we take care at UIC, we try to always make sure the patient has someone who can help navigate everything, the whole transplant or chemotherapy process, everything. I think it's the most important thing. And it's a team, so our nurses do a great job there, too.","_key":"5ae18d7fd6f60"}],"_type":"block"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"aae1b40ec78e","_type":"span"}],"_type":"block","style":"normal","_key":"40cfee73e7c7"},{"markDefs":[],"children":[{"_key":"2ad7234542580","_type":"span","marks":["strong"],"text":"What advice would you give to other oncologists who are looking to adopt more value-based approaches to managing multiple myeloma?"}],"_type":"block","style":"normal","_key":"fe3ab3738fcd"},{"_type":"block","style":"normal","_key":"2268d18ece05","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"","_key":"5d2c058d87ea"}]},{"children":[{"_type":"span","marks":[],"text":"My advice would be to, first, use the most effective therapies for myeloma that you have up front, and don't be afraid to use the new therapies that are available, especially the bispecifics and CAR T. We can select the patients who are the best patients to whom we can give those treatments. Make sure patients are not very frail or ultra frail; we can adapt those treatments according to their frailty status. But don't be afraid either to use them. Because these are all new treatments that make us anxious and make us go, \"What are we going to do if the patient gets a fever?\"—all those things, yeah— but don't be afraid to try to use targeted therapies in the right patient.","_key":"f29cd95236790"}],"_type":"block","style":"normal","_key":"5c501a207014","markDefs":[]}],"contentCategory":{"_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos","_id":"ee14ccb3-3542-4414-9046-927be1198c76","_updatedAt":"2020-04-03T20:03:44Z","_createdAt":"2020-04-03T20:03:44Z"},"published":"2024-11-29T14:21:00.000Z","_type":"article","is_visible":true},{"articleType":"Commentary","contentCategory":{"_id":"ee14ccb3-3542-4414-9046-927be1198c76","_updatedAt":"2020-04-03T20:03:44Z","_createdAt":"2020-04-03T20:03:44Z","_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos"},"ExcludeFromPubMedXML":false,"is_visible":true,"_type":"article","published":"2024-10-24T16:59:06.697Z","title":"MRD: A Game Changer in Multiple Myeloma","updatedOn":null,"factCheckAuthorMapping":null,"_rev":"Nphhc06GU7PslEeOdbRtob","summary":"In part 2 of our interview with Surbhi Sidana, MD, MBBS, American Society of Hematology and Stanford University, she delves into one of the hottest topics in the hematologic malignancy space today: minimal residual disease (MRD) status.","_createdAt":"2024-10-24T16:14:55Z","_id":"51b5be8a-83c6-4679-83e9-28c65886cfc3","url":{"current":"mrd-a-game-changer-in-multiple-myeloma","_type":"slug"},"seoTag":["multiple myeloma","isatuximab","surrogate end point"],"authorMapping":[{"displayName":"Maggie L. 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outcomes?"}],"_type":"block","style":"normal","_key":"033033bf6c86"},{"children":[{"_type":"span","marks":[],"text":"","_key":"6e442d7034d40"}],"_type":"block","style":"normal","_key":"5938bc942673","markDefs":[]},{"style":"normal","_key":"aad2e34a659e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Minimal residual disease is a sensitive way to measure disease that our current criteria cannot measure through blood-based testing or bone marrow–based testing.","_key":"00d2568842c00"}],"_type":"block"},{"_key":"8c0d279326bc","markDefs":[],"children":[{"marks":[],"text":"","_key":"17912850dabd0","_type":"span"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_key":"4b3feb5ff4ea0","_type":"span","marks":[],"text":"Historically, we evaluated myeloma through monoclonal proteins or free light chains in the blood and urine and percentage of plasma cells in the bone marrow. But this is like the iceberg: you can detect something on the surface, then you do a bone marrow [test and] you can detect something under the surface. But we know that even with those techniques, a lot of disease was left behind that they were just not sensitive enough to detect. So, MRD, or minimal residual disease, testing is just a more sensitive technique to detect disease that cannot be detected by conventional technologies."}],"_type":"block","style":"normal","_key":"42663d1d89af"},{"_type":"block","style":"normal","_key":"d5c4a53f535f","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"963bac9bb6f30"}]},{"_key":"9cd8bd26c74c","markDefs":[],"children":[{"text":"There's a couple of ways to do it by our current methodologies. Both of them right now rely on bone marrow testing: next-generation flow cytometry, which is an advanced flow cytometry to [provide a] more sensitive way of detection, or next-generation sequencing that detects the clone in myeloma at the time of diagnosis or relapse and tracks that clone through sequencing of the VDJ region in the plasma cell and just tracks that one clone to detect it at a very low level.","_key":"8f9de165a7cc0","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"style":"normal","_key":"10f739c2a94b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"bcb4ac9e5d860"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"It's just a sensitive way to detect disease that we couldn't previously detect. And what this tells us is that if you have low-level disease that we cannot detect by MRD—it doesn't mean there's no disease, just that these techniques cannot detect—those patients do better. We've seen that historically.","_key":"38d06ac96fe20"}],"_type":"block","style":"normal","_key":"005a8ef2b630"},{"style":"normal","_key":"cf90ac37678c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"e40841cfd7a60"}],"_type":"block"},{"_key":"1759ec02d35c","markDefs":[{"_key":"17839c83ace1","blank":true,"_type":"link","href":"https://www.ajmc.com/view/after-odac-what-s-next-for-mrd-testing-in-multiple-myeloma-"}],"children":[{"_type":"span","marks":[],"text":"Now, the FDA ODAC [Oncologic Drugs Advisory Committee] came out ","_key":"54b2dae43cf80"},{"_key":"54b2dae43cf81","_type":"span","marks":["17839c83ace1"],"text":"with a decision"},{"_type":"span","marks":[],"text":" that MRD will be used as a surrogate end point. They're open to that as a surrogate end point for drug approval. So, I think the field is moving in that direction. 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We're looking at safety, that's the primary outcome. In addition to that, we want to look at effectivity and the length of effectivity, meaning how long can we affect a progression-free survival in patients with multiple myeloma. And there are some correlative outcomes that we are looking at: integration of the DNA, persistence of the CAR T cells in patients, and immune-kind of end points, focusing on how long people are immunosuppressed and things like that.","_key":"f19bad2c58470"}],"_type":"block","style":"normal"},{"style":"normal","_key":"6ceca6880295","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"13696926069f0"}],"_type":"block"},{"_type":"block","style":"normal","_key":"7f9c6602b795","markDefs":[],"children":[{"marks":["strong"],"text":"Can you explain how your triple target approach works?","_key":"aa9887e8073f0","_type":"span"}]},{"_type":"block","style":"normal","_key":"b03ab975c7bd","markDefs":[],"children":[{"marks":[],"text":"","_key":"3039cd5658e40","_type":"span"}]},{"_type":"block","style":"normal","_key":"e001361f100a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"This CAR T cell is targeting 3 receptors on mature B cells and plasma cells. The typical CAR T cell will recognize 1. One of the most common is CD19, and that's used for the treatment of certain lymphomas. Another receptor that's being used in multiple myeloma is BCMA; that's a target for many CAR T cells for multiple myeloma.","_key":"e8c4f67eef340"}]},{"style":"normal","_key":"eabe158833ed","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"dfe7bc78720e0"}],"_type":"block"},{"_key":"ee83262dbcaa","markDefs":[],"children":[{"_type":"span","marks":[],"text":"This target is a ligand-based target, meaning there are receptors on the cell surface that attach to ligands, and this CAR T cell acts as kind of a fake ligand and will attach to 3 receptors on cell surfaces. One is the BAFF receptor, one is BCMA, and one is TACI. The benefit of being able to recognize and attach and then, therefore, attack the cells that have those receptors is that it's much harder for a cancer cell that has those 3 receptors—like certain types of lymphomas and myeloma—to downregulate all 3 receptors rather than just one. 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","body":[{"caption":"Ryan Jacobs, MD, Atrium Health Levine Cancer Institute","videoID":"6358992215112","disableAutoPlayVideo":false,"source":"brightcove","_key":"c4df04ec797e","videoObject":{"videoDescription":"interview with Ryan Jacobs, MD, Atrium Health Levine Cancer Institute","_type":"videoDetails","videoTitle":"Exploring the Efficacy and Safety of Ibrutinib and Venetoclax in CLL","thumbnail":{"_type":"image","asset":{"_ref":"image-8975edd8363de3a38e61e71410852276c595a645-1200x728-jpg","_type":"reference"}},"videoDuration":"PT2M11S"},"_type":"video"},{"children":[{"_type":"span","marks":[],"text":"At the recent ","_key":"c273a58eacd80"},{"_type":"span","marks":["437252032d33"],"text":"European Hematology Association 2024 Congress","_key":"c273a58eacd81"},{"_type":"span","marks":[],"text":", Ryan Jacobs, MD, lymphoma division director at Atrium Health Levine Cancer Institute, presented updated data from ","_key":"c273a58eacd82"},{"_type":"span","marks":["b62fba6f1791"],"text":"CAPTIVATE, a multicenter, phase 2 study","_key":"c273a58eacd83"},{"_type":"span","marks":[],"text":" with 2 patient cohorts that assessed outcomes among patients with chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL).","_key":"c273a58eacd84"}],"_type":"block","style":"normal","_key":"4c89f241aa34","markDefs":[{"blank":true,"_type":"link","href":"https://www.ajmc.com/conference/eha","_key":"437252032d33"},{"_type":"link","href":"https://www.clinicaltrials.gov/study/NCT02910583","_key":"b62fba6f1791","nofollow":true,"blank":true}]},{"children":[{"_type":"span","marks":[],"text":"","_key":"2b4015263fa60"}],"_type":"block","style":"normal","_key":"77ff1a4bb55c","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"In ","_key":"9cbf105480c70"},{"_type":"span","marks":["ee716024644f"],"text":"part 1","_key":"9cbf105480c71"},{"marks":[],"text":" of our interview with him, he explained how these long-term data show that a majority of patients with CLL had stable disease after 4.5 years of follow-up. 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It was a phase 2 study with an interest in exploring the efficacy and safety of putting the 2 most commonly used targeted treatments with small molecule inhibitors together, and that would be ibrutinib and venetoclax. At the time, ibrutinib was the only BTK [Bruton tyrosine kinase] inhibitor available. Of course, now there are additional BTK inhibitors. Venetoclax remains the only BCL2 inhibitor.","_key":"eae65433dc0a0"}],"_type":"block","style":"normal"},{"children":[{"text":"","_key":"17f41f6a4f4b0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"ee942b65ab57","markDefs":[]},{"_key":"7b121855e90e","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.clinicaltrials.gov/study/NCT01722487","_key":"1e950da20239"}],"children":[{"_type":"span","marks":[],"text":"We have been using BTK inhibitors a lot in treating CLL patients. They are wonderful in how effective they are. 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