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class="label">Followers</p><p class="data">15</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">13</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">13</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="user-bio-container"><div class="profile-bio fake-truncate js-profile-about" style="margin: 0px;">Translational physician  scientist Poet<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div 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id="Papers"><h3 class="profile--tab_heading_container">Papers by Frank Meyskens</h3></div><div class="js-work-strip profile--work_container" data-work-id="24926290"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/24926290/Effect_of_Selenium_and_Vitamin_E_on_Risk_of_Prostate_Cancer_and_Other_Cancers_The_Selenium_and_Vitamin_E_Cancer_Prevention_Trial_SELECT_"><img alt="Research paper thumbnail of Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers The Selenium and Vitamin E Cancer Prevention Trial (SELECT)" class="work-thumbnail" src="https://attachments.academia-assets.com/45255195/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/24926290/Effect_of_Selenium_and_Vitamin_E_on_Risk_of_Prostate_Cancer_and_Other_Cancers_The_Selenium_and_Vitamin_E_Cancer_Prevention_Trial_SELECT_">Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers The Selenium and Vitamin E Cancer Prevention Trial (SELECT)</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://upr.academia.edu/JaimeClaudioVillamil">Jaime Claudio Villamil</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FrankMeyskens">Frank Meyskens</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">"Context Secondary analyses of 2 randomized controlled trials and supportive epidemiologic...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">"Context  Secondary  analyses  of 2 randomized  controlled trials and  supportive  epidemiologic  and preclinical data  indicated the potential of selenium and vitamin E for preventing  prostate  cancer."<br /><br />Objective  To determine  whether  selenium,  vitamin E, or both could prevent  pros- tate cancer and other diseases  with little or no toxicity in relatively healthy  men.<br /><br />Conclusion  Selenium or vitamin E, alone or in combination at the doses and formula- tions used, did not prevent prostate cancer in this population of relatively healthy men."<br /><br />"Trial  Registration  clinicaltrials.gov identifier: NCT00006392"<br />"JAMA.  2009;301(1):39-51                                                                                                                                  <a href="http://www.jama.com" rel="nofollow">www.jama.com</a>"</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7ede87d181710ef2b9ab2664bcb71d60" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45255195,"asset_id":24926290,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45255195/download_file?st=MTczMjQzMzc0MCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="24926290"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div 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The cervix is easily accessible for examination and biopsy, and colposcopy improves visualization. Identifying chemopreventives in cervical cancer requires rigorous study design: dose de-escalating phase I, IIa trials; placebo-controlled phase IIb trials; and multicenter phase III trials. Reduction in disease incidence and surrogate endpoint biomarkers (SEB) may be trial endpoints. The goal of chemoprevention studies is to prevent or delay the development of cancer. Each agent requires a phase I or IIa trial for each organ site. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19324004"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19324004/A_community_based_feasibility_study_using_wheat_bran_fiber_supplementation_to_lower_colon_cancer_risk"><img alt="Research paper thumbnail of A community-based feasibility study using wheat bran fiber supplementation to lower colon cancer risk" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19324004/A_community_based_feasibility_study_using_wheat_bran_fiber_supplementation_to_lower_colon_cancer_risk">A community-based feasibility study using wheat bran fiber supplementation to lower colon cancer risk</a></div><div class="wp-workCard_item"><span>Preventive Medicine</span><span>, 1991</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In this feasibility study, free-living older adults (n = 180; means = 67.5 years old) were random...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this feasibility study, free-living older adults (n = 180; means = 67.5 years old) were randomly assigned to one of three levels of a 3-month standardized compliance enhancement program. Regarding subject compliance with the 18 g/day wheat bran fiber supplement, the high compliance enhancement group had a superior regimen compliance rate (88%) versus the medium and low groups, (66 and 29%, respectively) (P = 0.01), with similar attrition rates. No significant gastrointestinal side effects and changes in body weight were reported. 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For similar efficacy, the comprehensive compliance enhancement group had the greatest cost effectiveness.","internal_url":"https://www.academia.edu/19324004/A_community_based_feasibility_study_using_wheat_bran_fiber_supplementation_to_lower_colon_cancer_risk","translated_internal_url":"","created_at":"2015-12-01T15:09:40.708-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452416,"work_id":19324004,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688057,"email":"e***g@gmail.com","display_order":0,"name":"E. 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The AACR Task Force on the Treatment and Prevention of IEN has delineated the relationship between IEN and cancer risk as well as the clinical benefit that can be derived from reducing IEN burden. Although several effective endoscopic and surgical treatments for IEN have become standard medical practice, these interventions can confer morbidity and do not treat the entire epithelial field at risk. The incidence of many epithelial cancers is continuing to rise, the number of individuals at risk is increasing with the aging population, and the rapid advancement of imaging and molecular diagnostics is bringing to light precancers that were heretofore clinically silent. There is therefore an urgent need to rapidly develop...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="83d6d85d12ac4edb4873351d727184fb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":40556359,"asset_id":19324003,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/40556359/download_file?st=MTczMjQzMzc0MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19324003"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19324003"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19324003; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19324003]").text(description); $(".js-view-count[data-work-id=19324003]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19324003; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19324003']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19324003, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "83d6d85d12ac4edb4873351d727184fb" } } $('.js-work-strip[data-work-id=19324003]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19324003,"title":"Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent development","translated_title":"","metadata":{"abstract":"Precancer or intraepithelial neoplasia (IEN) is a noninvasive lesion that has genetic abnormalities, loss of cellular control functions, and some phenotypic characteristics of invasive cancer and that predicts for a substantial likelihood of developing invasive cancer. 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data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19324002/Plasma_tocopherols_and_risk_of_prostate_cancer_in_the_Selenium_and_Vitamin_E_Cancer_Prevention_Trial_SELECT_"><img alt="Research paper thumbnail of Plasma tocopherols and risk of prostate cancer in the Selenium and Vitamin E Cancer Prevention Trial (SELECT)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19324002/Plasma_tocopherols_and_risk_of_prostate_cancer_in_the_Selenium_and_Vitamin_E_Cancer_Prevention_Trial_SELECT_">Plasma tocopherols and risk of prostate cancer in the Selenium and Vitamin E Cancer Prevention Trial (SELECT)</a></div><div class="wp-workCard_item"><span>Cancer prevention research (Philadelphia, Pa.)</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The Selenium and Vitamin E Cancer Prevention Trial (SELECT) showed higher prostate cancer inciden...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The Selenium and Vitamin E Cancer Prevention Trial (SELECT) showed higher prostate cancer incidence in men supplemented with high-dose α-tocopherol. We, therefore, examined whether presupplementation plasma α-tocopherol or γ-tocopherol was associated with overall or high-grade prostate cancer. A stratified case-cohort sample that included 1,746 incident prostate cancer cases diagnosed through June 2009 and a subcohort of 3,211 men was derived from the SELECT trial of 35,533 men. Plasma was collected at entry from 2001 to 2004, and median follow-up was 5.5 years (range, 0-7.9 years). Incidence of prostate cancer as a function of plasma α-tocopherol, γ-tocopherol, and supplementation with α-tocopherol or selenomethionine was estimated by the hazard ratio (HR). Plasma γ-tocopherol was not associated with prostate cancer. Men with higher α-tocopherol concentrations seemed to have risk similar to that of men with lower concentrations [overall HR for fifth (Q5) vs. first quintile (Q1), 1....</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19324002"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19324002"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19324002; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19324002]").text(description); $(".js-view-count[data-work-id=19324002]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19324002; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19324002']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19324002, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19324002]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19324002,"title":"Plasma tocopherols and risk of prostate cancer in the Selenium and Vitamin E Cancer Prevention Trial (SELECT)","translated_title":"","metadata":{"abstract":"The Selenium and Vitamin E Cancer Prevention Trial (SELECT) showed higher prostate cancer incidence in men supplemented with high-dose α-tocopherol. 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Incidence of prostate cancer as a function of plasma α-tocopherol, γ-tocopherol, and supplementation with α-tocopherol or selenomethionine was estimated by the hazard ratio (HR). Plasma γ-tocopherol was not associated with prostate cancer. Men with higher α-tocopherol concentrations seemed to have risk similar to that of men with lower concentrations [overall HR for fifth (Q5) vs. first quintile (Q1), 1....","internal_url":"https://www.academia.edu/19324002/Plasma_tocopherols_and_risk_of_prostate_cancer_in_the_Selenium_and_Vitamin_E_Cancer_Prevention_Trial_SELECT_","translated_internal_url":"","created_at":"2015-12-01T15:09:40.474-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452335,"work_id":19324002,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688025,"email":"p***n@breastcenter.tmc.edu","display_order":0,"name":"Powel Brown","title":"Plasma tocopherols and risk of prostate cancer in the Selenium and Vitamin E Cancer Prevention Trial (SELECT)"},{"id":11452365,"work_id":19324002,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":348514,"email":"k***e@ccf.org","display_order":4194304,"name":"Eric Klein","title":"Plasma tocopherols and risk of prostate cancer in the Selenium and Vitamin E Cancer Prevention Trial (SELECT)"},{"id":11452368,"work_id":19324002,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":1590809,"email":"j***o@partners.org","display_order":6291456,"name":"J. 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Inhibition of polyamine synthesis suppresses carcinogen-induced epitheli- al cancers, including colon cancer, in animal models. In a short-term phase IIa trial, we determined that low doses of a-difluoromethylornithine (DFMO), an inhibitor of orni- thine decarboxylase (an enzyme involved in polyamine syn- thesis), reduced the polyamine content of</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="26237ef3466e489df57e3b11e53df476" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42097990,"asset_id":19324001,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42097990/download_file?st=MTczMjQzMzc0MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19324001"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19324001"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19324001; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19324001]").text(description); $(".js-view-count[data-work-id=19324001]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19324001; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19324001']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19324001, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "26237ef3466e489df57e3b11e53df476" } } $('.js-work-strip[data-work-id=19324001]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19324001,"title":"Effect of a-Difluoromethylornithine on Rectal Mucosal Levels of Polyamines in a Randomized, Double-Blinded Trial for Colon Cancer Prevention","translated_title":"","metadata":{"abstract":"Background: Polyamines (e.g., putrescine, spermidine, and spermine) are required for optimal cell growth. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19324000"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19324000/Executive_Summary_of_the_National_Cancer_Institute_Workshop_Highlights_and_recommendations"><img alt="Research paper thumbnail of Executive Summary of the National Cancer Institute Workshop: Highlights and recommendations" class="work-thumbnail" src="https://attachments.academia-assets.com/42097996/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19324000/Executive_Summary_of_the_National_Cancer_Institute_Workshop_Highlights_and_recommendations">Executive Summary of the National Cancer Institute Workshop: Highlights and recommendations</a></div><div class="wp-workCard_item"><span>Urology</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Prostate cancer chemoprevention represents a relatively new and promising strategy for reducing t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Prostate cancer chemoprevention represents a relatively new and promising strategy for reducing the immense public health burden of this devastating cancer of men in the United States and Western societies. Chemoprevention is defined as the administration of agents (drugs, biologics, and natural products) that modulate (inhibit) one or more steps in the multistage carcinogenesis process culminating in invasive adenocarcinoma of the prostate. In 2000, there were an estimated 170,000 new cases of prostate cancer and 31,000 deaths in the United States. During the past decade, the National Cancer Institute (NCI) organized the chemoprevention research program and began testing the first generation of promising agents (eg, 4-(hydroxy)-fenretinide [4-HPR], difluoromethylornithine [DFMO], antiandrogens) in high-risk cohorts and launched the first-large scale US phase 3 primary prevention trial, known as Prostate Cancer Prevention Trial (PCPT-1), in 18,000 average-risk men (age more than 55 years and prostate-specific antigen [PSA] less than 3 ng/mL) treated for 7 years with finasteride or placebo. In the summer of 1998, the NCI Prostate Cancer Progress Review Group (PRG) Report to the director of NCI was published in response to the leadership of the prostate cancer advocacy community in conjunction with Congress. To further elucidate and address critical issues identified in this report and to develop a research agenda for the newly created Prostate and Urologic Cancer Research Group in the Division of Cancer Prevention at NCI, the NCI organized the workshop &amp;quot;New Clinical Trial Strategies for Prostate Cancer Chemoprevention.&amp;quot; The major objectives were to promote understanding and cooperation among the NCI, US Food and Drug Administration (FDA), academia, pharmaceutical industry, and the public regarding new opportunities for clinical prevention trials for prostate cancer. The workshop was divided into three concurrent breakout panels and a fourth joint integrative panel. The workshop addressed multiple key areas identified in the PRG report in the following panels: (1) Molecular Targets and Promising Agents in Clinical Development; (2) Intermediate Endpoint Biomarkers for Prevention Trials; (3) High-Risk Study Populations for Prevention Trials, and (4) Preventive Clinical Trial Designs and Regulatory Issues. Expert panelists were drawn from leading academic, pharmaceutical, and government scientists in basic research and clinical investigation. Key pharmaceutical, biotechnology, academic, and National Institutes of Health scientists presented overviews of their new agents and products in clinical development (representing the next generation of promising agents). Senior FDA physicians from the Center for Drugs and Center for Biologics presented on current standards for new drug and biologic approval for chemoprevention efficacy. Some of the key topics included recent advances in the state of knowledge of promising agents in the clinic based on molecular targets as well as bottlenecks in drug development for pharmaceutical sponsors; strategic modulable biomarkers that can serve as primary endpoints in phase 1/2 trials to assess preventive efficacy; high-risk cohorts with precancer (high-grade prostatic intraepithelial neoplasia) and representative clinical trial designs that are ready for immediate translation into efficient prevention trials, such as Bayesian sequential monitoring for early assessment of biologic activity and factorial designs for assessment of multiagent combinations. Finally, each expert panel generated recommendations for areas of future research emphasizing opportunities and infrastructure needs.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="52abc4b0a193632876290a353d5ddf82" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42097996,"asset_id":19324000,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42097996/download_file?st=MTczMjQzMzc0MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19324000"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19324000"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19324000; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19324000]").text(description); $(".js-view-count[data-work-id=19324000]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19324000; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19324000']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19324000, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "52abc4b0a193632876290a353d5ddf82" } } $('.js-work-strip[data-work-id=19324000]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19324000,"title":"Executive Summary of the National Cancer Institute Workshop: Highlights and recommendations","translated_title":"","metadata":{"abstract":"Prostate cancer chemoprevention represents a relatively new and promising strategy for reducing the immense public health burden of this devastating cancer of men in the United States and Western societies. Chemoprevention is defined as the administration of agents (drugs, biologics, and natural products) that modulate (inhibit) one or more steps in the multistage carcinogenesis process culminating in invasive adenocarcinoma of the prostate. In 2000, there were an estimated 170,000 new cases of prostate cancer and 31,000 deaths in the United States. During the past decade, the National Cancer Institute (NCI) organized the chemoprevention research program and began testing the first generation of promising agents (eg, 4-(hydroxy)-fenretinide [4-HPR], difluoromethylornithine [DFMO], antiandrogens) in high-risk cohorts and launched the first-large scale US phase 3 primary prevention trial, known as Prostate Cancer Prevention Trial (PCPT-1), in 18,000 average-risk men (age more than 55 years and prostate-specific antigen [PSA] less than 3 ng/mL) treated for 7 years with finasteride or placebo. In the summer of 1998, the NCI Prostate Cancer Progress Review Group (PRG) Report to the director of NCI was published in response to the leadership of the prostate cancer advocacy community in conjunction with Congress. To further elucidate and address critical issues identified in this report and to develop a research agenda for the newly created Prostate and Urologic Cancer Research Group in the Division of Cancer Prevention at NCI, the NCI organized the workshop \u0026amp;quot;New Clinical Trial Strategies for Prostate Cancer Chemoprevention.\u0026amp;quot; The major objectives were to promote understanding and cooperation among the NCI, US Food and Drug Administration (FDA), academia, pharmaceutical industry, and the public regarding new opportunities for clinical prevention trials for prostate cancer. The workshop was divided into three concurrent breakout panels and a fourth joint integrative panel. 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href="https://www.academia.edu/19323999/Challenges_posed_by_non_random_missing_quality_of_life_data_in_an_advanced_stage_colorectal_cancer_clinical_trial"><img alt="Research paper thumbnail of Challenges posed by non‐random missing quality of life data in an advanced‐stage colorectal cancer clinical trial" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323999/Challenges_posed_by_non_random_missing_quality_of_life_data_in_an_advanced_stage_colorectal_cancer_clinical_trial">Challenges posed by non‐random missing quality of life data in an advanced‐stage colorectal cancer clinical trial</a></div><div class="wp-workCard_item"><span>Psycho‐Oncology</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Effects of variations in agent, dose, and route of treatment administration on patient reported q...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Effects of variations in agent, dose, and route of treatment administration on patient reported quality of life (QOL) were examined for 279 patients enrolled on a seven-arm randomized clinical trial (S8905) of 5-FU and its modulation for advanced colorectal cancer. Patients completed QOL questionnaires at randomization and weeks 6, 11, and 21 post-randomization with five QOL endpoints considered primary: three treatment-specific symptoms (stomatitis, diarrhea, and hand/foot sensitivity); physical functioning; and emotional functioning. Patient compliance with the QOL assessment schedule was good, supporting the feasibility of including QOL measures in cooperative group trials. However, death and deteriorating health produced substantial missing data. Cross-sectional analyses indicated that the seven therapeutic arms did not differ in their impact on QOL. Unfortunately, longitudinal analyses of the QOL data were inappropriate given non-random missing data. Graphical presentation of non-random missing data identified the seriousness of this problem and its effect on potential conclusions about QOL during treatment. This problem appears to be particularly challenging in the context of advanced-stage disease. Failure to recognize the presence of non-random missing data can lead to serious overestimates of patient QOL over time.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323999"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323999"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323999; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19323999]").text(description); $(".js-view-count[data-work-id=19323999]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19323999; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19323999']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19323999, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19323999]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19323999,"title":"Challenges posed by non‐random missing quality of life data in an advanced‐stage colorectal cancer clinical trial","translated_title":"","metadata":{"abstract":"Effects of variations in agent, dose, and route of treatment administration on patient reported quality of life (QOL) were examined for 279 patients enrolled on a seven-arm randomized clinical trial (S8905) of 5-FU and its modulation for advanced colorectal cancer. Patients completed QOL questionnaires at randomization and weeks 6, 11, and 21 post-randomization with five QOL endpoints considered primary: three treatment-specific symptoms (stomatitis, diarrhea, and hand/foot sensitivity); physical functioning; and emotional functioning. Patient compliance with the QOL assessment schedule was good, supporting the feasibility of including QOL measures in cooperative group trials. However, death and deteriorating health produced substantial missing data. Cross-sectional analyses indicated that the seven therapeutic arms did not differ in their impact on QOL. Unfortunately, longitudinal analyses of the QOL data were inappropriate given non-random missing data. Graphical presentation of non-random missing data identified the seriousness of this problem and its effect on potential conclusions about QOL during treatment. This problem appears to be particularly challenging in the context of advanced-stage disease. Failure to recognize the presence of non-random missing data can lead to serious overestimates of patient QOL over time.","publication_date":{"day":null,"month":null,"year":2000,"errors":{}},"publication_name":"Psycho‐Oncology"},"translated_abstract":"Effects of variations in agent, dose, and route of treatment administration on patient reported quality of life (QOL) were examined for 279 patients enrolled on a seven-arm randomized clinical trial (S8905) of 5-FU and its modulation for advanced colorectal cancer. Patients completed QOL questionnaires at randomization and weeks 6, 11, and 21 post-randomization with five QOL endpoints considered primary: three treatment-specific symptoms (stomatitis, diarrhea, and hand/foot sensitivity); physical functioning; and emotional functioning. Patient compliance with the QOL assessment schedule was good, supporting the feasibility of including QOL measures in cooperative group trials. However, death and deteriorating health produced substantial missing data. Cross-sectional analyses indicated that the seven therapeutic arms did not differ in their impact on QOL. Unfortunately, longitudinal analyses of the QOL data were inappropriate given non-random missing data. Graphical presentation of non-random missing data identified the seriousness of this problem and its effect on potential conclusions about QOL during treatment. This problem appears to be particularly challenging in the context of advanced-stage disease. Failure to recognize the presence of non-random missing data can lead to serious overestimates of patient QOL over time.","internal_url":"https://www.academia.edu/19323999/Challenges_posed_by_non_random_missing_quality_of_life_data_in_an_advanced_stage_colorectal_cancer_clinical_trial","translated_internal_url":"","created_at":"2015-12-01T15:09:40.075-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452408,"work_id":19323999,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688052,"email":"m***1@gcrc.med.nyu.edu","display_order":0,"name":"Franco Muggia","title":"Challenges posed by non‐random missing quality of life data in an advanced‐stage colorectal cancer clinical trial"}],"downloadable_attachments":[],"slug":"Challenges_posed_by_non_random_missing_quality_of_life_data_in_an_advanced_stage_colorectal_cancer_clinical_trial","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39578858,"first_name":"Frank","middle_initials":null,"last_name":"Meyskens","page_name":"FrankMeyskens","domain_name":"independent","created_at":"2015-12-01T15:09:08.450-08:00","display_name":"Frank Meyskens","url":"https://independent.academia.edu/FrankMeyskens"},"attachments":[],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design"},{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial"},{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life"},{"id":37292,"name":"Colorectal cancer","url":"https://www.academia.edu/Documents/in/Colorectal_cancer"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":93443,"name":"Psycho","url":"https://www.academia.edu/Documents/in/Psycho"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":135265,"name":"Psycho Oncology","url":"https://www.academia.edu/Documents/in/Psycho_Oncology"},{"id":153168,"name":"Data Collection","url":"https://www.academia.edu/Documents/in/Data_Collection"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires"},{"id":330953,"name":"Longitudinal Studies","url":"https://www.academia.edu/Documents/in/Longitudinal_Studies"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results"},{"id":936874,"name":"Bias (Epidemiology)","url":"https://www.academia.edu/Documents/in/Bias_Epidemiology_"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19323998"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19323998/Melanin_as_a_Target_for_Melanoma_Chemotherapy_Pro_oxidant_Effect_of_Oxygen_and_Metals_on_Melanoma_Viability"><img alt="Research paper thumbnail of Melanin as a Target for Melanoma Chemotherapy: Pro-oxidant Effect of Oxygen and Metals on Melanoma Viability" class="work-thumbnail" src="https://attachments.academia-assets.com/40556354/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323998/Melanin_as_a_Target_for_Melanoma_Chemotherapy_Pro_oxidant_Effect_of_Oxygen_and_Metals_on_Melanoma_Viability">Melanin as a Target for Melanoma Chemotherapy: Pro-oxidant Effect of Oxygen and Metals on Melanoma Viability</a></div><div class="wp-workCard_item"><span>Pigment Cell Research</span><span>, 2003</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="15730d6f456927141694259217bee18f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":40556354,"asset_id":19323998,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/40556354/download_file?st=MTczMjQzMzc0MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323998"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323998"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323998; 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We hypothesize that disorganization of the melanosomes will allow chemical targeting of the melanin within. Chemical studies show that under oxidative conditions, synthetic melanins demonstrate increased metal affinity and a susceptibility to redox cycling with oxygen to form reactive oxygen species. The electron paramagnetic resonance (EPR)active 5,5¢-dimethyl-pyrollidine N-oxide spin adduct was used to show that binding of divalent Zn or Cu to melanin induces a pro-oxidant response under oxygen, generating superoxide and hydroxyl radicals. A similar pro-oxidant behaviour is seen in melanoma cell lines under external peroxide stress. Melanoma cultures grown under 95% O 2 ⁄5% CO 2 atmospheres show markedly reduced viability as compared with normal melanocytes. Cu-and Zn-dithiocarbamate complexes, which induce passive uptake of the metal ions into cells, show significant antimelanoma activity. 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As drugs are developed to address these targets, there is a need for high-throughput systems that accurately reproduce in vivo microenvironments to gauge their efficacy. Accordingly, we have developed a three-dimensional in vitro culture system representative of the environment present upon secondary metastasis to quantitatively measure tumor cell invasion in this setting three-dimensionally. Culturing melanomas of different metastatic capacities within the system showed that each cell type invades the matrix in a manner commensurate to its known metastatic potential in vivo. Moreover, the developed quantitative schemes were put to use to characterize the effect of microenvironmental influences (i.e., matrix components, interstitial cell presence) on planar and vertical melanoma invasion. 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We propose this novel, quantitative system as a useful tool to assess the effects of pharmacologic and/or microenvironmental influences on tumor cell invasion at a metastatic site.","internal_url":"https://www.academia.edu/19323996/A_novel_three_dimensional_model_to_quantify_metastatic_melanoma_invasion","translated_internal_url":"","created_at":"2015-12-01T15:09:39.733-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452495,"work_id":19323996,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688084,"email":"c***r@fhcrc.org","display_order":0,"name":"C. Ghajar","title":"A novel three-dimensional model to quantify metastatic melanoma invasion"},{"id":11452496,"work_id":19323996,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688085,"email":"s***n@mit.edu","display_order":4194304,"name":"S. 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Raub","title":"A novel three-dimensional model to quantify metastatic melanoma invasion"}],"downloadable_attachments":[],"slug":"A_novel_three_dimensional_model_to_quantify_metastatic_melanoma_invasion","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39578858,"first_name":"Frank","middle_initials":null,"last_name":"Meyskens","page_name":"FrankMeyskens","domain_name":"independent","created_at":"2015-12-01T15:09:08.450-08:00","display_name":"Frank Meyskens","url":"https://independent.academia.edu/FrankMeyskens"},"attachments":[],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":29149,"name":"Extracellular Matrix","url":"https://www.academia.edu/Documents/in/Extracellular_Matrix"},{"id":46992,"name":"Molecular Biology Cancer","url":"https://www.academia.edu/Documents/in/Molecular_Biology_Cancer"},{"id":61095,"name":"Fibrin","url":"https://www.academia.edu/Documents/in/Fibrin"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":79808,"name":"Collagen","url":"https://www.academia.edu/Documents/in/Collagen"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":209510,"name":"Epidermis","url":"https://www.academia.edu/Documents/in/Epidermis"},{"id":371494,"name":"Neoplasm Invasiveness","url":"https://www.academia.edu/Documents/in/Neoplasm_Invasiveness"},{"id":413750,"name":"In vitro culture","url":"https://www.academia.edu/Documents/in/In_vitro_culture"},{"id":459378,"name":"Very high throughput","url":"https://www.academia.edu/Documents/in/Very_high_throughput"},{"id":504035,"name":"Three Dimensional","url":"https://www.academia.edu/Documents/in/Three_Dimensional"},{"id":787715,"name":"Molecular Cancer Therapeutics","url":"https://www.academia.edu/Documents/in/Molecular_Cancer_Therapeutics"},{"id":2177223,"name":"Skin Neoplasms","url":"https://www.academia.edu/Documents/in/Skin_Neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19323995"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19323995/Development_and_characteristics_of_a_human_cell_assay_for_screening_agents_for_melanoma_prevention"><img alt="Research paper thumbnail of Development and characteristics of a human cell assay for screening agents for melanoma prevention" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323995/Development_and_characteristics_of_a_human_cell_assay_for_screening_agents_for_melanoma_prevention">Development and characteristics of a human cell assay for screening agents for melanoma prevention</a></div><div class="wp-workCard_item"><span>Melanoma Research</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This paper describes the development and initial evaluation of a human cell assay to identify pot...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This paper describes the development and initial evaluation of a human cell assay to identify potentially efficacious agents for preventing melanoma. Four human cell lines were used: normal melanocytes, a radial growth-phase-like melanoma cell line (WM3211), a vertical growth-phase-like melanoma cell line (Lu1205), and 83-2c, a cell strain cloned from metastatic melanoma. Four endpoints were evaluated in ultraviolet B-treated cells: annexin V, human leukocyte antigen-DR; E-cadherin, and N-cadherin. Annexin V was induced by nimesulide, 4-hydroxyphenylretinamide, and difluoromethylornithine in ultraviolet-B-treated radial growth-phase-like melanoma cells. None of the agents inhibited human leukocyte antigen-DR expression in ultraviolet-B-treated radial growth-phase-like melanoma cells, the only cells that strongly expressed human leukocyte antigen-DR. E-cadherin was overexpressed only in radial growth-phase-like melanoma cells relative to melanocytes, and ultraviolet B exposure dramatically reduced this expression. E-cadherin was only induced by difluoromethylornithine in ultraviolet-B-treated radial growth-phase-like melanoma cells. N-cadherin was over- expressed in all melanoma cell lines relative to melanocytes. In this study, all candidate preventive agents inhibited N-cadherin in ultraviolet B-treated radial growth-phase-like melanoma cells. Four agents inhibited N-cadherin in ultraviolet B-treated vertical growth-phase-like melanoma cells. The mean ratios of N-cadherin to E-cadherin levels and specific endpoint responses for both the radial growth-phase-like melanoma and vertical growth-phase-like melanoma cells were used to rank the agents. Agents were evaluated at clinically relevant concentrations. The rankings were difluoromethylornithine&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;4-hydroxyphenylretinamide&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;nimesulide&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;9-cis-retinoic acid&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;polyphenon E. Diphenylhydramine, D-mannitol, and nordihydroguaiaretic acid were inactive. The results of these initial studies suggest that ultraviolet-B-treated radial growth-phase-like melanoma cells are the most responsive to chemopreventive agents, and may be the cell line of choice for screening melanoma prevention agents.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323995"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323995"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323995; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19323995]").text(description); $(".js-view-count[data-work-id=19323995]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19323995; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19323995']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19323995, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19323995]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19323995,"title":"Development and characteristics of a human cell assay for screening agents for melanoma prevention","translated_title":"","metadata":{"abstract":"This paper describes the development and initial evaluation of a human cell assay to identify potentially efficacious agents for preventing melanoma. Four human cell lines were used: normal melanocytes, a radial growth-phase-like melanoma cell line (WM3211), a vertical growth-phase-like melanoma cell line (Lu1205), and 83-2c, a cell strain cloned from metastatic melanoma. Four endpoints were evaluated in ultraviolet B-treated cells: annexin V, human leukocyte antigen-DR; E-cadherin, and N-cadherin. Annexin V was induced by nimesulide, 4-hydroxyphenylretinamide, and difluoromethylornithine in ultraviolet-B-treated radial growth-phase-like melanoma cells. None of the agents inhibited human leukocyte antigen-DR expression in ultraviolet-B-treated radial growth-phase-like melanoma cells, the only cells that strongly expressed human leukocyte antigen-DR. E-cadherin was overexpressed only in radial growth-phase-like melanoma cells relative to melanocytes, and ultraviolet B exposure dramatically reduced this expression. E-cadherin was only induced by difluoromethylornithine in ultraviolet-B-treated radial growth-phase-like melanoma cells. N-cadherin was over- expressed in all melanoma cell lines relative to melanocytes. In this study, all candidate preventive agents inhibited N-cadherin in ultraviolet B-treated radial growth-phase-like melanoma cells. Four agents inhibited N-cadherin in ultraviolet B-treated vertical growth-phase-like melanoma cells. The mean ratios of N-cadherin to E-cadherin levels and specific endpoint responses for both the radial growth-phase-like melanoma and vertical growth-phase-like melanoma cells were used to rank the agents. Agents were evaluated at clinically relevant concentrations. The rankings were difluoromethylornithine\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;4-hydroxyphenylretinamide\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;nimesulide\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;9-cis-retinoic acid\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;polyphenon E. Diphenylhydramine, D-mannitol, and nordihydroguaiaretic acid were inactive. The results of these initial studies suggest that ultraviolet-B-treated radial growth-phase-like melanoma cells are the most responsive to chemopreventive agents, and may be the cell line of choice for screening melanoma prevention agents.","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Melanoma Research"},"translated_abstract":"This paper describes the development and initial evaluation of a human cell assay to identify potentially efficacious agents for preventing melanoma. Four human cell lines were used: normal melanocytes, a radial growth-phase-like melanoma cell line (WM3211), a vertical growth-phase-like melanoma cell line (Lu1205), and 83-2c, a cell strain cloned from metastatic melanoma. Four endpoints were evaluated in ultraviolet B-treated cells: annexin V, human leukocyte antigen-DR; E-cadherin, and N-cadherin. Annexin V was induced by nimesulide, 4-hydroxyphenylretinamide, and difluoromethylornithine in ultraviolet-B-treated radial growth-phase-like melanoma cells. None of the agents inhibited human leukocyte antigen-DR expression in ultraviolet-B-treated radial growth-phase-like melanoma cells, the only cells that strongly expressed human leukocyte antigen-DR. E-cadherin was overexpressed only in radial growth-phase-like melanoma cells relative to melanocytes, and ultraviolet B exposure dramatically reduced this expression. E-cadherin was only induced by difluoromethylornithine in ultraviolet-B-treated radial growth-phase-like melanoma cells. N-cadherin was over- expressed in all melanoma cell lines relative to melanocytes. In this study, all candidate preventive agents inhibited N-cadherin in ultraviolet B-treated radial growth-phase-like melanoma cells. Four agents inhibited N-cadherin in ultraviolet B-treated vertical growth-phase-like melanoma cells. The mean ratios of N-cadherin to E-cadherin levels and specific endpoint responses for both the radial growth-phase-like melanoma and vertical growth-phase-like melanoma cells were used to rank the agents. Agents were evaluated at clinically relevant concentrations. The rankings were difluoromethylornithine\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;4-hydroxyphenylretinamide\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;nimesulide\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;9-cis-retinoic acid\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;polyphenon E. Diphenylhydramine, D-mannitol, and nordihydroguaiaretic acid were inactive. The results of these initial studies suggest that ultraviolet-B-treated radial growth-phase-like melanoma cells are the most responsive to chemopreventive agents, and may be the cell line of choice for screening melanoma prevention agents.","internal_url":"https://www.academia.edu/19323995/Development_and_characteristics_of_a_human_cell_assay_for_screening_agents_for_melanoma_prevention","translated_internal_url":"","created_at":"2015-12-01T15:09:39.625-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452477,"work_id":19323995,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688073,"email":"a***j@hs.uci.edu","display_order":0,"name":"Aarti Jain","title":"Development and characteristics of a human cell assay for screening agents for melanoma prevention"},{"id":11452478,"work_id":19323995,"tagging_user_id":39578858,"tagged_user_id":278482955,"co_author_invite_id":2688074,"email":"s***a@gmail.com","display_order":4194304,"name":"Shazia Siddiqi","title":"Development and characteristics of a human cell assay for screening agents for melanoma prevention"}],"downloadable_attachments":[],"slug":"Development_and_characteristics_of_a_human_cell_assay_for_screening_agents_for_melanoma_prevention","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39578858,"first_name":"Frank","middle_initials":null,"last_name":"Meyskens","page_name":"FrankMeyskens","domain_name":"independent","created_at":"2015-12-01T15:09:08.450-08:00","display_name":"Frank Meyskens","url":"https://independent.academia.edu/FrankMeyskens"},"attachments":[],"research_interests":[{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant"},{"id":346418,"name":"Foreskin","url":"https://www.academia.edu/Documents/in/Foreskin"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results"},{"id":701219,"name":"Melanocytes","url":"https://www.academia.edu/Documents/in/Melanocytes"},{"id":2177223,"name":"Skin Neoplasms","url":"https://www.academia.edu/Documents/in/Skin_Neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19323994"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19323994/An_Exploratory_Study_of_Attitudes_Beliefs_and_Practices_Related_to_the_Interim_Dietary_Guidelines_for_Reducing_Cancer_in_the_Elderly"><img alt="Research paper thumbnail of An Exploratory Study of Attitudes, Beliefs and Practices Related to the Interim Dietary Guidelines for Reducing Cancer in the Elderly" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323994/An_Exploratory_Study_of_Attitudes_Beliefs_and_Practices_Related_to_the_Interim_Dietary_Guidelines_for_Reducing_Cancer_in_the_Elderly">An Exploratory Study of Attitudes, Beliefs and Practices Related to the Interim Dietary Guidelines for Reducing Cancer in the Elderly</a></div><div class="wp-workCard_item"><span>Journal of Nutrition For the Elderly</span><span>, 1991</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In this pilot study, a self-administered questionnaire was used to assess the health attitudes, b...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this pilot study, a self-administered questionnaire was used to assess the health attitudes, beliefs and practices related to each of the Interim Dietary Guidelines for Reducing Cancer Risk (I.D.G.R.C.R.) in a convenience sample of elderly Caucasian subjects (N = 30) over 60 years old. The questionnaire items included personal efficacy, perceived motivators and barriers, and current practices related to the compliance of each of the dietary guidelines. The distributions of responses to the questionnaire items show variations in the subjects&amp;#39; attitudes, beliefs and current dietary practices related to each of the dietary guidelines. Most subjects reported current practice of most guidelines except the guideline of a low fat diet. Most of the time, the subjects perceived one or more motivations to comply with the guidelines of eating fruits and vegetables high in vitamin C, and eating dark green or deep yellow vegetables. Taste and health benefits were shown to be important factors among motivators influencing the compliance to the dietary guidelines. The findings of this exploratory study have direct implications for planning nutrition intervention programs for cancer risk reduction in the elderly.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323994"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323994"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323994; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19323994]").text(description); $(".js-view-count[data-work-id=19323994]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19323994; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19323994']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19323994, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19323994]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19323994,"title":"An Exploratory Study of Attitudes, Beliefs and Practices Related to the Interim Dietary Guidelines for Reducing Cancer in the Elderly","translated_title":"","metadata":{"abstract":"In this pilot study, a self-administered questionnaire was used to assess the health attitudes, beliefs and practices related to each of the Interim Dietary Guidelines for Reducing Cancer Risk (I.D.G.R.C.R.) in a convenience sample of elderly Caucasian subjects (N = 30) over 60 years old. The questionnaire items included personal efficacy, perceived motivators and barriers, and current practices related to the compliance of each of the dietary guidelines. The distributions of responses to the questionnaire items show variations in the subjects\u0026amp;#39; attitudes, beliefs and current dietary practices related to each of the dietary guidelines. Most subjects reported current practice of most guidelines except the guideline of a low fat diet. Most of the time, the subjects perceived one or more motivations to comply with the guidelines of eating fruits and vegetables high in vitamin C, and eating dark green or deep yellow vegetables. Taste and health benefits were shown to be important factors among motivators influencing the compliance to the dietary guidelines. The findings of this exploratory study have direct implications for planning nutrition intervention programs for cancer risk reduction in the elderly.","publication_date":{"day":null,"month":null,"year":1991,"errors":{}},"publication_name":"Journal of Nutrition For the Elderly"},"translated_abstract":"In this pilot study, a self-administered questionnaire was used to assess the health attitudes, beliefs and practices related to each of the Interim Dietary Guidelines for Reducing Cancer Risk (I.D.G.R.C.R.) in a convenience sample of elderly Caucasian subjects (N = 30) over 60 years old. The questionnaire items included personal efficacy, perceived motivators and barriers, and current practices related to the compliance of each of the dietary guidelines. The distributions of responses to the questionnaire items show variations in the subjects\u0026amp;#39; attitudes, beliefs and current dietary practices related to each of the dietary guidelines. Most subjects reported current practice of most guidelines except the guideline of a low fat diet. Most of the time, the subjects perceived one or more motivations to comply with the guidelines of eating fruits and vegetables high in vitamin C, and eating dark green or deep yellow vegetables. Taste and health benefits were shown to be important factors among motivators influencing the compliance to the dietary guidelines. The findings of this exploratory study have direct implications for planning nutrition intervention programs for cancer risk reduction in the elderly.","internal_url":"https://www.academia.edu/19323994/An_Exploratory_Study_of_Attitudes_Beliefs_and_Practices_Related_to_the_Interim_Dietary_Guidelines_for_Reducing_Cancer_in_the_Elderly","translated_internal_url":"","created_at":"2015-12-01T15:09:39.519-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452417,"work_id":19323994,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688057,"email":"e***g@gmail.com","display_order":0,"name":"E. Ho","title":"An Exploratory Study of Attitudes, Beliefs and Practices Related to the Interim Dietary Guidelines for Reducing Cancer in the Elderly"}],"downloadable_attachments":[],"slug":"An_Exploratory_Study_of_Attitudes_Beliefs_and_Practices_Related_to_the_Interim_Dietary_Guidelines_for_Reducing_Cancer_in_the_Elderly","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39578858,"first_name":"Frank","middle_initials":null,"last_name":"Meyskens","page_name":"FrankMeyskens","domain_name":"independent","created_at":"2015-12-01T15:09:08.450-08:00","display_name":"Frank Meyskens","url":"https://independent.academia.edu/FrankMeyskens"},"attachments":[],"research_interests":[{"id":591,"name":"Nutrition and Dietetics","url":"https://www.academia.edu/Documents/in/Nutrition_and_Dietetics"},{"id":8207,"name":"Risk","url":"https://www.academia.edu/Documents/in/Risk"},{"id":9478,"name":"Diet","url":"https://www.academia.edu/Documents/in/Diet"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":82981,"name":"vitamin C","url":"https://www.academia.edu/Documents/in/vitamin_C"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":135005,"name":"Patient Compliance","url":"https://www.academia.edu/Documents/in/Patient_Compliance"},{"id":229398,"name":"Fruit and vegetables","url":"https://www.academia.edu/Documents/in/Fruit_and_vegetables"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":308908,"name":"Pilot study","url":"https://www.academia.edu/Documents/in/Pilot_study"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1"},{"id":469018,"name":"Neoplasms","url":"https://www.academia.edu/Documents/in/Neoplasms"},{"id":945595,"name":"Pilot Projects","url":"https://www.academia.edu/Documents/in/Pilot_Projects"},{"id":1212936,"name":"Cancer Risk","url":"https://www.academia.edu/Documents/in/Cancer_Risk"},{"id":2019300,"name":"Exploratory Study","url":"https://www.academia.edu/Documents/in/Exploratory_Study"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19323993"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19323993/_Difluoromethylornithine_and_Polyamine_Levels_in_the_Human_Prostate_Results_of_a_Phase_IIa_Trial"><img alt="Research paper thumbnail of -Difluoromethylornithine and Polyamine Levels in the Human Prostate: Results of a Phase IIa Trial" class="work-thumbnail" src="https://attachments.academia-assets.com/42097992/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323993/_Difluoromethylornithine_and_Polyamine_Levels_in_the_Human_Prostate_Results_of_a_Phase_IIa_Trial"> -Difluoromethylornithine and Polyamine Levels in the Human Prostate: Results of a Phase IIa Trial</a></div><div class="wp-workCard_item"><span>JNCI Journal of the National Cancer Institute</span><span>, 2001</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eb6e105efb6e1d64c570ae7f8c474148" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42097992,"asset_id":19323993,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42097992/download_file?st=MTczMjQzMzc0MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323993"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323993"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323993; 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As such, the prevention of prostate cancer is of national medical concern. One approach to prevention of prostate cancer is to suppress the polyamine levels in the prostate, an avenue suggested by studies indicating that ornithine decarboxylase (ODC), the first enzyme in the polyamine pathway, is overexpressed in human prostate cancer tissue (2) and is the target enzyme for ␣-difluoromethylornithine (DFMO). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19323992"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19323992/Effects_of_Dietary_Wheat_Bran_Fiber_on_Rectal_Epithelial_Cell_Proliferation_in_Patients_With_Research_for_Colorectal_Cancers"><img alt="Research paper thumbnail of Effects of Dietary Wheat Bran Fiber on Rectal Epithelial Cell Proliferation in Patients With Research for Colorectal Cancers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323992/Effects_of_Dietary_Wheat_Bran_Fiber_on_Rectal_Epithelial_Cell_Proliferation_in_Patients_With_Research_for_Colorectal_Cancers">Effects of Dietary Wheat Bran Fiber on Rectal Epithelial Cell Proliferation in Patients With Research for Colorectal Cancers</a></div><div class="wp-workCard_item"><span>JNCI Journal of the National Cancer Institute</span><span>, 1990</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A preponderance of carcinogenesis studies in rodents and epidemiologic studies in humans suggests...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A preponderance of carcinogenesis studies in rodents and epidemiologic studies in humans suggests a potential role of dietary fiber in the prevention of colorectal cancer. Recently, wheat bran fiber used as a dietary supplement has been shown to decrease the growth of rectal adenomatous polyps in patients with familial polyposis; however, few studies of high-risk human populations have been attempted to determine the effects of dietary fiber supplementation on markers of carcinogenesis in the colon or rectum. We have designed a one-arm study to evaluate the effects of dietary supplementation with wheat bran fiber [i.e., 13.5 g/day for 8 wk; after 1 mo, 2 g/day (compliance evaluation period)] on [3H]thymidine rectal mucosa cell labeling (i.e., percent of epithelial cells incorporating [3H]thymidine into DNA in intact rectal crypt cells over a 90-min exposure as well as in minced rectal biopsy tissue over a 24-hr exposure) in rectal biopsy specimens. The biopsy specimens were obtained at sigmoidoscopy in 17 compliant patients with a history of resected colon or rectal cancer. We categorized patients as having initially low or initially high [3H]thymidine-labeling indices (i.e., percent of mucosa cells that incorporate [3H]thymidine into DNA during 1.5- or 24-hour in vitro incubations) by using the median baseline labeling index as a cutoff between high and low values. On the basis of a chi-square test used to identify patients with a statistically significant (P less than .001) change, six of the eight patients who initially had high 24-hour outgrowth labeling indices showed a significant decrease in the rectal mucosa biopsy specimens obtained after treatment. An overall 22% decrease was observed in rectal mucosa cell biopsy specimens obtained at study termination (P less than .001). Of the eight patients with initially high total [3H]thymidine-labeling indices in crypt organ culture, four had a significant (P less than .001) decrease from baseline values, one had a significant increase, and three showed no change following the fiber intervention. The wheat bran fiber dietary supplement of 13.5 g/day was well tolerated by this group of older (54-70 yr) patients. Although the [3H]-thymidine labeling index data suggest that the wheat bran fiber supplement can inhibit DNA synthesis and rectal mucosa cell proliferation in high-risk patients, the results of this small pilot study should not be overinterpreted vis à vis the potential role of wheat bran fiber as a chemopreventive agent for colorectal cancer.(ABSTRACT TRUNCATED AT 400 WORDS)</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323992"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323992"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323992; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19323992]").text(description); $(".js-view-count[data-work-id=19323992]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19323992; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19323992']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19323992, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19323992]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19323992,"title":"Effects of Dietary Wheat Bran Fiber on Rectal Epithelial Cell Proliferation in Patients With Research for Colorectal Cancers","translated_title":"","metadata":{"abstract":"A preponderance of carcinogenesis studies in rodents and epidemiologic studies in humans suggests a potential role of dietary fiber in the prevention of colorectal cancer. 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We categorized patients as having initially low or initially high [3H]thymidine-labeling indices (i.e., percent of mucosa cells that incorporate [3H]thymidine into DNA during 1.5- or 24-hour in vitro incubations) by using the median baseline labeling index as a cutoff between high and low values. On the basis of a chi-square test used to identify patients with a statistically significant (P less than .001) change, six of the eight patients who initially had high 24-hour outgrowth labeling indices showed a significant decrease in the rectal mucosa biopsy specimens obtained after treatment. An overall 22% decrease was observed in rectal mucosa cell biopsy specimens obtained at study termination (P less than .001). Of the eight patients with initially high total [3H]thymidine-labeling indices in crypt organ culture, four had a significant (P less than .001) decrease from baseline values, one had a significant increase, and three showed no change following the fiber intervention. 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We categorized patients as having initially low or initially high [3H]thymidine-labeling indices (i.e., percent of mucosa cells that incorporate [3H]thymidine into DNA during 1.5- or 24-hour in vitro incubations) by using the median baseline labeling index as a cutoff between high and low values. On the basis of a chi-square test used to identify patients with a statistically significant (P less than .001) change, six of the eight patients who initially had high 24-hour outgrowth labeling indices showed a significant decrease in the rectal mucosa biopsy specimens obtained after treatment. An overall 22% decrease was observed in rectal mucosa cell biopsy specimens obtained at study termination (P less than .001). Of the eight patients with initially high total [3H]thymidine-labeling indices in crypt organ culture, four had a significant (P less than .001) decrease from baseline values, one had a significant increase, and three showed no change following the fiber intervention. 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Although the [3H]-thymidine labeling index data suggest that the wheat bran fiber supplement can inhibit DNA synthesis and rectal mucosa cell proliferation in high-risk patients, the results of this small pilot study should not be overinterpreted vis à vis the potential role of wheat bran fiber as a chemopreventive agent for colorectal cancer.(ABSTRACT TRUNCATED AT 400 WORDS)","internal_url":"https://www.academia.edu/19323992/Effects_of_Dietary_Wheat_Bran_Fiber_on_Rectal_Epithelial_Cell_Proliferation_in_Patients_With_Research_for_Colorectal_Cancers","translated_internal_url":"","created_at":"2015-12-01T15:09:39.296-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452396,"work_id":19323992,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688043,"email":"m***r@ucollege.edu","display_order":0,"name":"M. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19323991"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19323991/Quality_of_Life_in_Advanced_Prostate_Cancer_Results_of_a_Randomized_Therapeutic_Trial"><img alt="Research paper thumbnail of Quality of Life in Advanced Prostate Cancer: Results of a Randomized Therapeutic Trial" class="work-thumbnail" src="https://attachments.academia-assets.com/40556358/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323991/Quality_of_Life_in_Advanced_Prostate_Cancer_Results_of_a_Randomized_Therapeutic_Trial">Quality of Life in Advanced Prostate Cancer: Results of a Randomized Therapeutic Trial</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FrankMeyskens">Frank Meyskens</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MarioEisenberger">Mario Eisenberger</a></span></div><div class="wp-workCard_item"><span>JNCI Journal of the National Cancer Institute</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a71d40dd4f1555d1d9d8f2b0e32d937b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":40556358,"asset_id":19323991,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/40556358/download_file?st=MTczMjQzMzc0MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323991"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323991"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323991; 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To help document the achievement of palliation and to characterize positive and negative effects of treatment, we evaluated qualityof-life (QOL) parameters in patients with metastatic prostate cancer who were randomly assigned to two methods of androgen deprivation. Methods: Patients (n = 739) with stage M 1 (bone or soft tissue metastasis) prostate cancer were enrolled in a QOL protocol that was a companion to Southwest Oncology Group INT-0105, a randomized doubleblind trial comparing treatment with bilateral orchiectomy (surgical castration) plus either flutamide or placebo. Patients completed a comprehensive battery of QOL questionnaires at random assignment to treatment and at 1, 3, and 6 months later. Data were collected on three treatment-specific symptoms (diarrhea, gas pain, and body image), on physical functioning, and on emotional functioning. All P values are two-sided. Results: Questionnaire return rates for this study never dropped below 80%; only 2% of the patients did not submit baseline QOL assessments. Cross-sectional analyses (corrected for multiple testing) identified statistically significant differences that favored orchiectomy plus placebo for two of the five primary QOL parameters as follows: patients receiving flutamide reported more diarrhea at 3 months (P = .001) and worse emotional functioning at 3 and 6 months (both P\u003c.003). Longitudinal analyses replicated these findings. Other analyzed QOL parameters favored the group receiving placebo but were not statistically significant after adjustment for multiple testing. Conclusions: We found a consistent pattern of better QOL outcomes at each follow-up assessment during the first 6 months of treatment for orchiectomized patients with metastatic prostate cancer who received placebo versus flutamide. Improvement over time was evident in both treatment groups but more so for patients receiving placebo. [J Natl Cancer Inst 1998;90:1537-44]","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"JNCI Journal of the National Cancer Institute","grobid_abstract_attachment_id":40556358},"translated_abstract":null,"internal_url":"https://www.academia.edu/19323991/Quality_of_Life_in_Advanced_Prostate_Cancer_Results_of_a_Randomized_Therapeutic_Trial","translated_internal_url":"","created_at":"2015-12-01T15:09:39.194-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452371,"work_id":19323991,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688035,"email":"e***d@uiowa.edu","display_order":0,"name":"E. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19323990"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19323990/Effect_of_Difluoromethylornithine_on_Rectal_Mucosal_Levels_of_Polyamines_in_a_Randomized_Double_Blinded_Trial_for_Colon_Cancer_Prevention"><img alt="Research paper thumbnail of Effect of -Difluoromethylornithine on Rectal Mucosal Levels of Polyamines in a Randomized, Double-Blinded Trial for Colon Cancer Prevention" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323990/Effect_of_Difluoromethylornithine_on_Rectal_Mucosal_Levels_of_Polyamines_in_a_Randomized_Double_Blinded_Trial_for_Colon_Cancer_Prevention">Effect of -Difluoromethylornithine on Rectal Mucosal Levels of Polyamines in a Randomized, Double-Blinded Trial for Colon Cancer Prevention</a></div><div class="wp-workCard_item"><span>JNCI Journal of the National Cancer Institute</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Polyamines (e.g., putrescine, spermidine, and spermine) are required for optimal cell growth. Inh...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Polyamines (e.g., putrescine, spermidine, and spermine) are required for optimal cell growth. Inhibition of polyamine synthesis suppresses carcinogen-induced epithelial cancers, including colon cancer, in animal models. In a short-term phase IIa trial, we determined that low doses of alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (an enzyme involved in polyamine synthesis), reduced the polyamine content of normal-appearing rectal mucosa of subjects with a prior history of resected colon polyps. In a follow-up study, we have attempted to determine the lowest dose of DFMO that can suppress the polyamine content of rectal mucosa over a course of 1 year with no or minimal side effects. Participants were randomly assigned to daily oral treatment with a placebo or one of three doses (0.075, 0.20, or 0.40 g/m2) of DFMO. Baseline and serial determinations of polyamine levels in rectal mucosa and extensive symptom monitoring (including audiometric measurements, since DFMO causes some reversible hearing loss at higher doses) were performed over a 15-month period. DFMO treatment reduced putrescine levels in a dose-dependent manner. Following 6 months of treatment, doses of 0.20 and 0.40 g/m2 per day reduced putrescine levels to approximately 34% and 10%, respectively, of those observed in the placebo group. Smaller decreases were seen in spermidine levels and spermidine:spermine ratios. Polyamine levels increased toward baseline values after discontinuation of DFMO. Although there were no statistically significant differences among the dose groups with respect to clinically important shifts in audiometric thresholds and nonaudiologic side effects, statistically significant higher dropout and discontinuation rates were observed in the highest dose group. Polyamine levels in rectal mucosa can be continuously suppressed by daily oral doses of DFMO that produce few or no side effects. A dose of 0.20 g/m2 can be used safely in combination phase IIb or single-agent phase III chemoprevention trials.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323990"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323990"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323990; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19323990]").text(description); $(".js-view-count[data-work-id=19323990]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19323990; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19323990']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19323990, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19323990]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19323990,"title":"Effect of -Difluoromethylornithine on Rectal Mucosal Levels of Polyamines in a Randomized, Double-Blinded Trial for Colon Cancer Prevention","translated_title":"","metadata":{"abstract":"Polyamines (e.g., putrescine, spermidine, and spermine) are required for optimal cell growth. Inhibition of polyamine synthesis suppresses carcinogen-induced epithelial cancers, including colon cancer, in animal models. In a short-term phase IIa trial, we determined that low doses of alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (an enzyme involved in polyamine synthesis), reduced the polyamine content of normal-appearing rectal mucosa of subjects with a prior history of resected colon polyps. In a follow-up study, we have attempted to determine the lowest dose of DFMO that can suppress the polyamine content of rectal mucosa over a course of 1 year with no or minimal side effects. Participants were randomly assigned to daily oral treatment with a placebo or one of three doses (0.075, 0.20, or 0.40 g/m2) of DFMO. Baseline and serial determinations of polyamine levels in rectal mucosa and extensive symptom monitoring (including audiometric measurements, since DFMO causes some reversible hearing loss at higher doses) were performed over a 15-month period. DFMO treatment reduced putrescine levels in a dose-dependent manner. Following 6 months of treatment, doses of 0.20 and 0.40 g/m2 per day reduced putrescine levels to approximately 34% and 10%, respectively, of those observed in the placebo group. Smaller decreases were seen in spermidine levels and spermidine:spermine ratios. Polyamine levels increased toward baseline values after discontinuation of DFMO. Although there were no statistically significant differences among the dose groups with respect to clinically important shifts in audiometric thresholds and nonaudiologic side effects, statistically significant higher dropout and discontinuation rates were observed in the highest dose group. Polyamine levels in rectal mucosa can be continuously suppressed by daily oral doses of DFMO that produce few or no side effects. A dose of 0.20 g/m2 can be used safely in combination phase IIb or single-agent phase III chemoprevention trials.","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"JNCI Journal of the National Cancer Institute"},"translated_abstract":"Polyamines (e.g., putrescine, spermidine, and spermine) are required for optimal cell growth. Inhibition of polyamine synthesis suppresses carcinogen-induced epithelial cancers, including colon cancer, in animal models. In a short-term phase IIa trial, we determined that low doses of alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (an enzyme involved in polyamine synthesis), reduced the polyamine content of normal-appearing rectal mucosa of subjects with a prior history of resected colon polyps. In a follow-up study, we have attempted to determine the lowest dose of DFMO that can suppress the polyamine content of rectal mucosa over a course of 1 year with no or minimal side effects. Participants were randomly assigned to daily oral treatment with a placebo or one of three doses (0.075, 0.20, or 0.40 g/m2) of DFMO. Baseline and serial determinations of polyamine levels in rectal mucosa and extensive symptom monitoring (including audiometric measurements, since DFMO causes some reversible hearing loss at higher doses) were performed over a 15-month period. DFMO treatment reduced putrescine levels in a dose-dependent manner. Following 6 months of treatment, doses of 0.20 and 0.40 g/m2 per day reduced putrescine levels to approximately 34% and 10%, respectively, of those observed in the placebo group. Smaller decreases were seen in spermidine levels and spermidine:spermine ratios. Polyamine levels increased toward baseline values after discontinuation of DFMO. Although there were no statistically significant differences among the dose groups with respect to clinically important shifts in audiometric thresholds and nonaudiologic side effects, statistically significant higher dropout and discontinuation rates were observed in the highest dose group. Polyamine levels in rectal mucosa can be continuously suppressed by daily oral doses of DFMO that produce few or no side effects. A dose of 0.20 g/m2 can be used safely in combination phase IIb or single-agent phase III chemoprevention trials.","internal_url":"https://www.academia.edu/19323990/Effect_of_Difluoromethylornithine_on_Rectal_Mucosal_Levels_of_Polyamines_in_a_Randomized_Double_Blinded_Trial_for_Colon_Cancer_Prevention","translated_internal_url":"","created_at":"2015-12-01T15:09:39.093-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452383,"work_id":19323990,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2198257,"email":"s***n@u.washington.edu","display_order":0,"name":"Scot Emerson","title":"Effect of -Difluoromethylornithine on Rectal Mucosal Levels of Polyamines in a Randomized, Double-Blinded Trial for Colon Cancer Prevention"},{"id":11452385,"work_id":19323990,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688038,"email":"k***e@nuigalway.ie","display_order":4194304,"name":"Karen Doyle","title":"Effect of -Difluoromethylornithine on Rectal Mucosal Levels of Polyamines in a Randomized, Double-Blinded Trial for Colon Cancer Prevention"}],"downloadable_attachments":[],"slug":"Effect_of_Difluoromethylornithine_on_Rectal_Mucosal_Levels_of_Polyamines_in_a_Randomized_Double_Blinded_Trial_for_Colon_Cancer_Prevention","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39578858,"first_name":"Frank","middle_initials":null,"last_name":"Meyskens","page_name":"FrankMeyskens","domain_name":"independent","created_at":"2015-12-01T15:09:08.450-08:00","display_name":"Frank Meyskens","url":"https://independent.academia.edu/FrankMeyskens"},"attachments":[],"research_interests":[{"id":420802,"name":"Colon cancer","url":"https://www.academia.edu/Documents/in/Colon_cancer"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19323989"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19323989/Protein_kinase_C%CE%B2_expression_in_melanoma_cells_and_melanocytes_differential_expression_correlates_with_biological_responses_to_12_O_tetradecanoylphorbol_13_acetate"><img alt="Research paper thumbnail of Protein kinase Cβ expression in melanoma cells and melanocytes: differential expression correlates with biological responses to 12-O-tetradecanoylphorbol 13-acetate" class="work-thumbnail" src="https://attachments.academia-assets.com/42097991/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323989/Protein_kinase_C%CE%B2_expression_in_melanoma_cells_and_melanocytes_differential_expression_correlates_with_biological_responses_to_12_O_tetradecanoylphorbol_13_acetate">Protein kinase Cβ expression in melanoma cells and melanocytes: differential expression correlates with biological responses to 12-O-tetradecanoylphorbol 13-acetate</a></div><div class="wp-workCard_item"><span>Journal of Cancer Research and Clinical Oncology</span><span>, 1993</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Page 1. J Cancer Res Clin Oncol (1993) 119:199-206 Joum~lf Cancer esearch Ci nical @ncology 9 Spr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Page 1. J Cancer Res Clin Oncol (1993) 119:199-206 Joum~lf Cancer esearch Ci nical @ncology 9 Springer-Verlag 1993 Protein kinase C 13 expression in melanoma cells and melanocytes: differential expression correlates with ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="169af1fae48f33b4bd884c0d5102235d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42097991,"asset_id":19323989,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42097991/download_file?st=MTczMjQzMzc0MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323989"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323989"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323989; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19323989]").text(description); $(".js-view-count[data-work-id=19323989]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19323989; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19323989']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19323989, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "169af1fae48f33b4bd884c0d5102235d" } } $('.js-work-strip[data-work-id=19323989]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19323989,"title":"Protein kinase Cβ expression in melanoma cells and melanocytes: differential expression correlates with biological responses to 12-O-tetradecanoylphorbol 13-acetate","translated_title":"","metadata":{"abstract":"Page 1. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19323988"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19323988/A_study_of_reproductive_function_in_patients_with_seminoma_treated_with_radiotherapy_and_orchidectomy_SWOG_8711_"><img alt="Research paper thumbnail of A study of reproductive function in patients with seminoma treated with radiotherapy and orchidectomy: (SWOG-8711)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323988/A_study_of_reproductive_function_in_patients_with_seminoma_treated_with_radiotherapy_and_orchidectomy_SWOG_8711_">A study of reproductive function in patients with seminoma treated with radiotherapy and orchidectomy: (SWOG-8711)</a></div><div class="wp-workCard_item"><span>International Journal of Radiation Oncology*Biology*Physics</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The results of Southwest Oncology Group Study 8711 (Group 2B) are presented. The objective was to...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The results of Southwest Oncology Group Study 8711 (Group 2B) are presented. The objective was to evaluate the natural history of sperm concentration and selected hormonal parameters in patients with testicular cancer treated with orchiectomy and radiotherapy. Of a total of 207 patients enrolled on SWOG 8711, 53 pure seminoma patients were identified who were treated with orchiectomy and radiotherapy only. Sperm concentration, follicle-stimulating hormone (FSH) levels, and sexual satisfaction scores were the main parameters followed. A fraction of the patients were infertile prior to receiving radiotherapy. Our analysis indicates that incidental radiation dose to the remaining testicle affects time to recovery of fertility, and at an aggregate level, changes in FSH mirror changes in sperm concentration over time. This phenomenon is the same as that described in patients free from testicular cancer. These men evaluated their sexual activity as good after orchidectomy. Our data support the use of clamshell-type testicular shields as a means of providing maximum protection to the remaining testicle.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323988"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323988"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323988; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19323988]").text(description); $(".js-view-count[data-work-id=19323988]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19323988; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19323988']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19323988, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19323988]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19323988,"title":"A study of reproductive function in patients with seminoma treated with radiotherapy and orchidectomy: (SWOG-8711)","translated_title":"","metadata":{"abstract":"The results of Southwest Oncology Group Study 8711 (Group 2B) are presented. The objective was to evaluate the natural history of sperm concentration and selected hormonal parameters in patients with testicular cancer treated with orchiectomy and radiotherapy. Of a total of 207 patients enrolled on SWOG 8711, 53 pure seminoma patients were identified who were treated with orchiectomy and radiotherapy only. Sperm concentration, follicle-stimulating hormone (FSH) levels, and sexual satisfaction scores were the main parameters followed. A fraction of the patients were infertile prior to receiving radiotherapy. Our analysis indicates that incidental radiation dose to the remaining testicle affects time to recovery of fertility, and at an aggregate level, changes in FSH mirror changes in sperm concentration over time. This phenomenon is the same as that described in patients free from testicular cancer. These men evaluated their sexual activity as good after orchidectomy. Our data support the use of clamshell-type testicular shields as a means of providing maximum protection to the remaining testicle.","publication_date":{"day":null,"month":null,"year":1997,"errors":{}},"publication_name":"International Journal of Radiation Oncology*Biology*Physics"},"translated_abstract":"The results of Southwest Oncology Group Study 8711 (Group 2B) are presented. The objective was to evaluate the natural history of sperm concentration and selected hormonal parameters in patients with testicular cancer treated with orchiectomy and radiotherapy. Of a total of 207 patients enrolled on SWOG 8711, 53 pure seminoma patients were identified who were treated with orchiectomy and radiotherapy only. Sperm concentration, follicle-stimulating hormone (FSH) levels, and sexual satisfaction scores were the main parameters followed. A fraction of the patients were infertile prior to receiving radiotherapy. Our analysis indicates that incidental radiation dose to the remaining testicle affects time to recovery of fertility, and at an aggregate level, changes in FSH mirror changes in sperm concentration over time. This phenomenon is the same as that described in patients free from testicular cancer. These men evaluated their sexual activity as good after orchidectomy. Our data support the use of clamshell-type testicular shields as a means of providing maximum protection to the remaining testicle.","internal_url":"https://www.academia.edu/19323988/A_study_of_reproductive_function_in_patients_with_seminoma_treated_with_radiotherapy_and_orchidectomy_SWOG_8711_","translated_internal_url":"","created_at":"2015-12-01T15:09:38.915-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452400,"work_id":19323988,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688047,"email":"d***n@nwmissouri.edu","display_order":0,"name":"William Gordon","title":"A study of reproductive function in patients with seminoma treated with radiotherapy and orchidectomy: (SWOG-8711)"}],"downloadable_attachments":[],"slug":"A_study_of_reproductive_function_in_patients_with_seminoma_treated_with_radiotherapy_and_orchidectomy_SWOG_8711_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39578858,"first_name":"Frank","middle_initials":null,"last_name":"Meyskens","page_name":"FrankMeyskens","domain_name":"independent","created_at":"2015-12-01T15:09:08.450-08:00","display_name":"Frank Meyskens","url":"https://independent.academia.edu/FrankMeyskens"},"attachments":[],"research_interests":[{"id":4559,"name":"Reproduction","url":"https://www.academia.edu/Documents/in/Reproduction"},{"id":4571,"name":"Sex","url":"https://www.academia.edu/Documents/in/Sex"},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers"},{"id":963536,"name":"Sperm Count","url":"https://www.academia.edu/Documents/in/Sperm_Count"},{"id":1310139,"name":"Follicle stimulating hormone","url":"https://www.academia.edu/Documents/in/Follicle_stimulating_hormone"},{"id":1971275,"name":"Seminoma","url":"https://www.academia.edu/Documents/in/Seminoma"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="4203457" id="papers"><div class="js-work-strip profile--work_container" data-work-id="24926290"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/24926290/Effect_of_Selenium_and_Vitamin_E_on_Risk_of_Prostate_Cancer_and_Other_Cancers_The_Selenium_and_Vitamin_E_Cancer_Prevention_Trial_SELECT_"><img alt="Research paper thumbnail of Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers The Selenium and Vitamin E Cancer Prevention Trial (SELECT)" class="work-thumbnail" src="https://attachments.academia-assets.com/45255195/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/24926290/Effect_of_Selenium_and_Vitamin_E_on_Risk_of_Prostate_Cancer_and_Other_Cancers_The_Selenium_and_Vitamin_E_Cancer_Prevention_Trial_SELECT_">Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers The Selenium and Vitamin E Cancer Prevention Trial (SELECT)</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://upr.academia.edu/JaimeClaudioVillamil">Jaime Claudio Villamil</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FrankMeyskens">Frank Meyskens</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">"Context Secondary analyses of 2 randomized controlled trials and supportive epidemiologic...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">"Context  Secondary  analyses  of 2 randomized  controlled trials and  supportive  epidemiologic  and preclinical data  indicated the potential of selenium and vitamin E for preventing  prostate  cancer."<br /><br />Objective  To determine  whether  selenium,  vitamin E, or both could prevent  pros- tate cancer and other diseases  with little or no toxicity in relatively healthy  men.<br /><br />Conclusion  Selenium or vitamin E, alone or in combination at the doses and formula- tions used, did not prevent prostate cancer in this population of relatively healthy men."<br /><br />"Trial  Registration  clinicaltrials.gov identifier: NCT00006392"<br />"JAMA.  2009;301(1):39-51                                                                                                                                  <a href="http://www.jama.com" rel="nofollow">www.jama.com</a>"</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7ede87d181710ef2b9ab2664bcb71d60" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45255195,"asset_id":24926290,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45255195/download_file?st=MTczMjQzMzc0Miw4LjIyMi4yMDguMTQ2&st=MTczMjQzMzc0MCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="24926290"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="24926290"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24926290; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=24926290]").text(description); $(".js-view-count[data-work-id=24926290]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 24926290; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='24926290']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 24926290, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7ede87d181710ef2b9ab2664bcb71d60" } } $('.js-work-strip[data-work-id=24926290]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":24926290,"title":"Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers The Selenium and Vitamin E Cancer Prevention Trial (SELECT)","translated_title":"","metadata":{"abstract":"\"Context Secondary analyses of 2 randomized controlled trials and supportive epidemiologic and preclinical data indicated the potential of selenium and vitamin E for preventing prostate cancer.\"\n\nObjective To determine whether selenium, vitamin E, or both could prevent pros- tate cancer and other diseases with little or no toxicity in relatively healthy men.\n\nConclusion Selenium or vitamin E, alone or in combination at the doses and formula- tions used, did not prevent prostate cancer in this population of relatively healthy men.\"\n\n\"Trial Registration clinicaltrials.gov identifier: NCT00006392\"\n\"JAMA. 2009;301(1):39-51 www.jama.com\""},"translated_abstract":"\"Context Secondary analyses of 2 randomized controlled trials and supportive epidemiologic and preclinical data indicated the potential of selenium and vitamin E for preventing prostate cancer.\"\n\nObjective To determine whether selenium, vitamin E, or both could prevent pros- tate cancer and other diseases with little or no toxicity in relatively healthy men.\n\nConclusion Selenium or vitamin E, alone or in combination at the doses and formula- tions used, did not prevent prostate cancer in this population of relatively healthy men.\"\n\n\"Trial Registration clinicaltrials.gov identifier: NCT00006392\"\n\"JAMA. 2009;301(1):39-51 www.jama.com\"","internal_url":"https://www.academia.edu/24926290/Effect_of_Selenium_and_Vitamin_E_on_Risk_of_Prostate_Cancer_and_Other_Cancers_The_Selenium_and_Vitamin_E_Cancer_Prevention_Trial_SELECT_","translated_internal_url":"","created_at":"2016-05-01T12:47:43.244-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":5585268,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":19717630,"work_id":24926290,"tagging_user_id":5585268,"tagged_user_id":39578858,"co_author_invite_id":null,"email":"f***s@canprevent.com","display_order":0,"name":"Frank Meyskens","title":"Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers The Selenium and Vitamin E Cancer Prevention Trial (SELECT)"},{"id":19717631,"work_id":24926290,"tagging_user_id":5585268,"tagged_user_id":33290302,"co_author_invite_id":null,"email":"j***b@u.washington.edu","affiliation":"University of Washington","display_order":4194304,"name":"Jeffrey Probstfield","title":"Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers The Selenium and Vitamin E Cancer Prevention Trial (SELECT)"},{"id":19717632,"work_id":24926290,"tagging_user_id":5585268,"tagged_user_id":39070245,"co_author_invite_id":null,"email":"r***1@columbia.edu","display_order":6291456,"name":"Regina Santella","title":"Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers The Selenium and Vitamin E Cancer Prevention Trial (SELECT)"},{"id":19717633,"work_id":24926290,"tagging_user_id":5585268,"tagged_user_id":38998051,"co_author_invite_id":null,"email":"p***h@mail.nih.gov","display_order":7340032,"name":"Howard Parnes","title":"Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers The Selenium and Vitamin E Cancer Prevention Trial (SELECT)"},{"id":19717634,"work_id":24926290,"tagging_user_id":5585268,"tagged_user_id":null,"co_author_invite_id":358446,"email":"m***o@mail.nih.gov","display_order":7864320,"name":"Lori Minasian","title":"Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers The Selenium and Vitamin E Cancer Prevention Trial (SELECT)"},{"id":19717635,"work_id":24926290,"tagging_user_id":5585268,"tagged_user_id":42080479,"co_author_invite_id":null,"email":"f***e@uci.edu","display_order":8126464,"name":"F. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19324005"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19324005/Why_phase_II_trials_in_cervical_chemoprevention_are_negative_what_have_we_learned"><img alt="Research paper thumbnail of Why phase II trials in cervical chemoprevention are negative: what have we learned?" class="work-thumbnail" src="https://attachments.academia-assets.com/40556360/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19324005/Why_phase_II_trials_in_cervical_chemoprevention_are_negative_what_have_we_learned">Why phase II trials in cervical chemoprevention are negative: what have we learned?</a></div><div class="wp-workCard_item"><span>Cancer causes & control : CCC</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cervical cancer is an important cause of mortality in women worldwide, and the cervix is a well-e...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cervical cancer is an important cause of mortality in women worldwide, and the cervix is a well-established clinical, cytologic, and histopathologic model of carcinogenesis. The cervix is easily accessible for examination and biopsy, and colposcopy improves visualization. Identifying chemopreventives in cervical cancer requires rigorous study design: dose de-escalating phase I, IIa trials; placebo-controlled phase IIb trials; and multicenter phase III trials. Reduction in disease incidence and surrogate endpoint biomarkers (SEB) may be trial endpoints. The goal of chemoprevention studies is to prevent or delay the development of cancer. Each agent requires a phase I or IIa trial for each organ site. 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means = 67.5 years old) were random...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this feasibility study, free-living older adults (n = 180; means = 67.5 years old) were randomly assigned to one of three levels of a 3-month standardized compliance enhancement program. Regarding subject compliance with the 18 g/day wheat bran fiber supplement, the high compliance enhancement group had a superior regimen compliance rate (88%) versus the medium and low groups, (66 and 29%, respectively) (P = 0.01), with similar attrition rates. No significant gastrointestinal side effects and changes in body weight were reported. 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For similar efficacy, the comprehensive compliance enhancement group had the greatest cost effectiveness.","internal_url":"https://www.academia.edu/19324004/A_community_based_feasibility_study_using_wheat_bran_fiber_supplementation_to_lower_colon_cancer_risk","translated_internal_url":"","created_at":"2015-12-01T15:09:40.708-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452416,"work_id":19324004,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688057,"email":"e***g@gmail.com","display_order":0,"name":"E. 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The AACR Task Force on the Treatment and Prevention of IEN has delineated the relationship between IEN and cancer risk as well as the clinical benefit that can be derived from reducing IEN burden. Although several effective endoscopic and surgical treatments for IEN have become standard medical practice, these interventions can confer morbidity and do not treat the entire epithelial field at risk. The incidence of many epithelial cancers is continuing to rise, the number of individuals at risk is increasing with the aging population, and the rapid advancement of imaging and molecular diagnostics is bringing to light precancers that were heretofore clinically silent. There is therefore an urgent need to rapidly develop...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="83d6d85d12ac4edb4873351d727184fb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":40556359,"asset_id":19324003,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/40556359/download_file?st=MTczMjQzMzc0Miw4LjIyMi4yMDguMTQ2&st=MTczMjQzMzc0MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19324003"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19324003"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19324003; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19324003]").text(description); $(".js-view-count[data-work-id=19324003]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19324003; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19324003']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19324003, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "83d6d85d12ac4edb4873351d727184fb" } } $('.js-work-strip[data-work-id=19324003]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19324003,"title":"Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent development","translated_title":"","metadata":{"abstract":"Precancer or intraepithelial neoplasia (IEN) is a noninvasive lesion that has genetic abnormalities, loss of cellular control functions, and some phenotypic characteristics of invasive cancer and that predicts for a substantial likelihood of developing invasive cancer. 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data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19324002/Plasma_tocopherols_and_risk_of_prostate_cancer_in_the_Selenium_and_Vitamin_E_Cancer_Prevention_Trial_SELECT_"><img alt="Research paper thumbnail of Plasma tocopherols and risk of prostate cancer in the Selenium and Vitamin E Cancer Prevention Trial (SELECT)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19324002/Plasma_tocopherols_and_risk_of_prostate_cancer_in_the_Selenium_and_Vitamin_E_Cancer_Prevention_Trial_SELECT_">Plasma tocopherols and risk of prostate cancer in the Selenium and Vitamin E Cancer Prevention Trial (SELECT)</a></div><div class="wp-workCard_item"><span>Cancer prevention research (Philadelphia, Pa.)</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The Selenium and Vitamin E Cancer Prevention Trial (SELECT) showed higher prostate cancer inciden...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The Selenium and Vitamin E Cancer Prevention Trial (SELECT) showed higher prostate cancer incidence in men supplemented with high-dose α-tocopherol. We, therefore, examined whether presupplementation plasma α-tocopherol or γ-tocopherol was associated with overall or high-grade prostate cancer. A stratified case-cohort sample that included 1,746 incident prostate cancer cases diagnosed through June 2009 and a subcohort of 3,211 men was derived from the SELECT trial of 35,533 men. Plasma was collected at entry from 2001 to 2004, and median follow-up was 5.5 years (range, 0-7.9 years). Incidence of prostate cancer as a function of plasma α-tocopherol, γ-tocopherol, and supplementation with α-tocopherol or selenomethionine was estimated by the hazard ratio (HR). Plasma γ-tocopherol was not associated with prostate cancer. 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Inhibition of polyamine synthesis suppresses carcinogen-induced epitheli- al cancers, including colon cancer, in animal models. In a short-term phase IIa trial, we determined that low doses of a-difluoromethylornithine (DFMO), an inhibitor of orni- thine decarboxylase (an enzyme involved in polyamine syn- thesis), reduced the polyamine content of</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="26237ef3466e489df57e3b11e53df476" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42097990,"asset_id":19324001,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42097990/download_file?st=MTczMjQzMzc0Miw4LjIyMi4yMDguMTQ2&st=MTczMjQzMzc0MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19324001"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19324001"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19324001; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19324001]").text(description); $(".js-view-count[data-work-id=19324001]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19324001; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19324001']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19324001, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "26237ef3466e489df57e3b11e53df476" } } $('.js-work-strip[data-work-id=19324001]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19324001,"title":"Effect of a-Difluoromethylornithine on Rectal Mucosal Levels of Polyamines in a Randomized, Double-Blinded Trial for Colon Cancer Prevention","translated_title":"","metadata":{"abstract":"Background: Polyamines (e.g., putrescine, spermidine, and spermine) are required for optimal cell growth. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19324000"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19324000/Executive_Summary_of_the_National_Cancer_Institute_Workshop_Highlights_and_recommendations"><img alt="Research paper thumbnail of Executive Summary of the National Cancer Institute Workshop: Highlights and recommendations" class="work-thumbnail" src="https://attachments.academia-assets.com/42097996/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19324000/Executive_Summary_of_the_National_Cancer_Institute_Workshop_Highlights_and_recommendations">Executive Summary of the National Cancer Institute Workshop: Highlights and recommendations</a></div><div class="wp-workCard_item"><span>Urology</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Prostate cancer chemoprevention represents a relatively new and promising strategy for reducing t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Prostate cancer chemoprevention represents a relatively new and promising strategy for reducing the immense public health burden of this devastating cancer of men in the United States and Western societies. Chemoprevention is defined as the administration of agents (drugs, biologics, and natural products) that modulate (inhibit) one or more steps in the multistage carcinogenesis process culminating in invasive adenocarcinoma of the prostate. In 2000, there were an estimated 170,000 new cases of prostate cancer and 31,000 deaths in the United States. During the past decade, the National Cancer Institute (NCI) organized the chemoprevention research program and began testing the first generation of promising agents (eg, 4-(hydroxy)-fenretinide [4-HPR], difluoromethylornithine [DFMO], antiandrogens) in high-risk cohorts and launched the first-large scale US phase 3 primary prevention trial, known as Prostate Cancer Prevention Trial (PCPT-1), in 18,000 average-risk men (age more than 55 years and prostate-specific antigen [PSA] less than 3 ng/mL) treated for 7 years with finasteride or placebo. In the summer of 1998, the NCI Prostate Cancer Progress Review Group (PRG) Report to the director of NCI was published in response to the leadership of the prostate cancer advocacy community in conjunction with Congress. To further elucidate and address critical issues identified in this report and to develop a research agenda for the newly created Prostate and Urologic Cancer Research Group in the Division of Cancer Prevention at NCI, the NCI organized the workshop &amp;quot;New Clinical Trial Strategies for Prostate Cancer Chemoprevention.&amp;quot; The major objectives were to promote understanding and cooperation among the NCI, US Food and Drug Administration (FDA), academia, pharmaceutical industry, and the public regarding new opportunities for clinical prevention trials for prostate cancer. The workshop was divided into three concurrent breakout panels and a fourth joint integrative panel. The workshop addressed multiple key areas identified in the PRG report in the following panels: (1) Molecular Targets and Promising Agents in Clinical Development; (2) Intermediate Endpoint Biomarkers for Prevention Trials; (3) High-Risk Study Populations for Prevention Trials, and (4) Preventive Clinical Trial Designs and Regulatory Issues. Expert panelists were drawn from leading academic, pharmaceutical, and government scientists in basic research and clinical investigation. Key pharmaceutical, biotechnology, academic, and National Institutes of Health scientists presented overviews of their new agents and products in clinical development (representing the next generation of promising agents). Senior FDA physicians from the Center for Drugs and Center for Biologics presented on current standards for new drug and biologic approval for chemoprevention efficacy. Some of the key topics included recent advances in the state of knowledge of promising agents in the clinic based on molecular targets as well as bottlenecks in drug development for pharmaceutical sponsors; strategic modulable biomarkers that can serve as primary endpoints in phase 1/2 trials to assess preventive efficacy; high-risk cohorts with precancer (high-grade prostatic intraepithelial neoplasia) and representative clinical trial designs that are ready for immediate translation into efficient prevention trials, such as Bayesian sequential monitoring for early assessment of biologic activity and factorial designs for assessment of multiagent combinations. Finally, each expert panel generated recommendations for areas of future research emphasizing opportunities and infrastructure needs.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="52abc4b0a193632876290a353d5ddf82" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42097996,"asset_id":19324000,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42097996/download_file?st=MTczMjQzMzc0Miw4LjIyMi4yMDguMTQ2&st=MTczMjQzMzc0MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19324000"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19324000"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19324000; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19324000]").text(description); $(".js-view-count[data-work-id=19324000]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19324000; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19324000']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19324000, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "52abc4b0a193632876290a353d5ddf82" } } $('.js-work-strip[data-work-id=19324000]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19324000,"title":"Executive Summary of the National Cancer Institute Workshop: Highlights and recommendations","translated_title":"","metadata":{"abstract":"Prostate cancer chemoprevention represents a relatively new and promising strategy for reducing the immense public health burden of this devastating cancer of men in the United States and Western societies. Chemoprevention is defined as the administration of agents (drugs, biologics, and natural products) that modulate (inhibit) one or more steps in the multistage carcinogenesis process culminating in invasive adenocarcinoma of the prostate. In 2000, there were an estimated 170,000 new cases of prostate cancer and 31,000 deaths in the United States. During the past decade, the National Cancer Institute (NCI) organized the chemoprevention research program and began testing the first generation of promising agents (eg, 4-(hydroxy)-fenretinide [4-HPR], difluoromethylornithine [DFMO], antiandrogens) in high-risk cohorts and launched the first-large scale US phase 3 primary prevention trial, known as Prostate Cancer Prevention Trial (PCPT-1), in 18,000 average-risk men (age more than 55 years and prostate-specific antigen [PSA] less than 3 ng/mL) treated for 7 years with finasteride or placebo. In the summer of 1998, the NCI Prostate Cancer Progress Review Group (PRG) Report to the director of NCI was published in response to the leadership of the prostate cancer advocacy community in conjunction with Congress. To further elucidate and address critical issues identified in this report and to develop a research agenda for the newly created Prostate and Urologic Cancer Research Group in the Division of Cancer Prevention at NCI, the NCI organized the workshop \u0026amp;quot;New Clinical Trial Strategies for Prostate Cancer Chemoprevention.\u0026amp;quot; The major objectives were to promote understanding and cooperation among the NCI, US Food and Drug Administration (FDA), academia, pharmaceutical industry, and the public regarding new opportunities for clinical prevention trials for prostate cancer. The workshop was divided into three concurrent breakout panels and a fourth joint integrative panel. The workshop addressed multiple key areas identified in the PRG report in the following panels: (1) Molecular Targets and Promising Agents in Clinical Development; (2) Intermediate Endpoint Biomarkers for Prevention Trials; (3) High-Risk Study Populations for Prevention Trials, and (4) Preventive Clinical Trial Designs and Regulatory Issues. Expert panelists were drawn from leading academic, pharmaceutical, and government scientists in basic research and clinical investigation. Key pharmaceutical, biotechnology, academic, and National Institutes of Health scientists presented overviews of their new agents and products in clinical development (representing the next generation of promising agents). Senior FDA physicians from the Center for Drugs and Center for Biologics presented on current standards for new drug and biologic approval for chemoprevention efficacy. 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During the past decade, the National Cancer Institute (NCI) organized the chemoprevention research program and began testing the first generation of promising agents (eg, 4-(hydroxy)-fenretinide [4-HPR], difluoromethylornithine [DFMO], antiandrogens) in high-risk cohorts and launched the first-large scale US phase 3 primary prevention trial, known as Prostate Cancer Prevention Trial (PCPT-1), in 18,000 average-risk men (age more than 55 years and prostate-specific antigen [PSA] less than 3 ng/mL) treated for 7 years with finasteride or placebo. In the summer of 1998, the NCI Prostate Cancer Progress Review Group (PRG) Report to the director of NCI was published in response to the leadership of the prostate cancer advocacy community in conjunction with Congress. To further elucidate and address critical issues identified in this report and to develop a research agenda for the newly created Prostate and Urologic Cancer Research Group in the Division of Cancer Prevention at NCI, the NCI organized the workshop \u0026amp;quot;New Clinical Trial Strategies for Prostate Cancer Chemoprevention.\u0026amp;quot; The major objectives were to promote understanding and cooperation among the NCI, US Food and Drug Administration (FDA), academia, pharmaceutical industry, and the public regarding new opportunities for clinical prevention trials for prostate cancer. The workshop was divided into three concurrent breakout panels and a fourth joint integrative panel. The workshop addressed multiple key areas identified in the PRG report in the following panels: (1) Molecular Targets and Promising Agents in Clinical Development; (2) Intermediate Endpoint Biomarkers for Prevention Trials; (3) High-Risk Study Populations for Prevention Trials, and (4) Preventive Clinical Trial Designs and Regulatory Issues. Expert panelists were drawn from leading academic, pharmaceutical, and government scientists in basic research and clinical investigation. Key pharmaceutical, biotechnology, academic, and National Institutes of Health scientists presented overviews of their new agents and products in clinical development (representing the next generation of promising agents). Senior FDA physicians from the Center for Drugs and Center for Biologics presented on current standards for new drug and biologic approval for chemoprevention efficacy. 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href="https://www.academia.edu/19323999/Challenges_posed_by_non_random_missing_quality_of_life_data_in_an_advanced_stage_colorectal_cancer_clinical_trial"><img alt="Research paper thumbnail of Challenges posed by non‐random missing quality of life data in an advanced‐stage colorectal cancer clinical trial" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323999/Challenges_posed_by_non_random_missing_quality_of_life_data_in_an_advanced_stage_colorectal_cancer_clinical_trial">Challenges posed by non‐random missing quality of life data in an advanced‐stage colorectal cancer clinical trial</a></div><div class="wp-workCard_item"><span>Psycho‐Oncology</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Effects of variations in agent, dose, and route of treatment administration on patient reported q...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Effects of variations in agent, dose, and route of treatment administration on patient reported quality of life (QOL) were examined for 279 patients enrolled on a seven-arm randomized clinical trial (S8905) of 5-FU and its modulation for advanced colorectal cancer. Patients completed QOL questionnaires at randomization and weeks 6, 11, and 21 post-randomization with five QOL endpoints considered primary: three treatment-specific symptoms (stomatitis, diarrhea, and hand/foot sensitivity); physical functioning; and emotional functioning. Patient compliance with the QOL assessment schedule was good, supporting the feasibility of including QOL measures in cooperative group trials. However, death and deteriorating health produced substantial missing data. Cross-sectional analyses indicated that the seven therapeutic arms did not differ in their impact on QOL. Unfortunately, longitudinal analyses of the QOL data were inappropriate given non-random missing data. Graphical presentation of non-random missing data identified the seriousness of this problem and its effect on potential conclusions about QOL during treatment. This problem appears to be particularly challenging in the context of advanced-stage disease. Failure to recognize the presence of non-random missing data can lead to serious overestimates of patient QOL over time.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323999"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323999"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323999; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19323999]").text(description); $(".js-view-count[data-work-id=19323999]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19323999; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19323999']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19323999, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19323999]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19323999,"title":"Challenges posed by non‐random missing quality of life data in an advanced‐stage colorectal cancer clinical trial","translated_title":"","metadata":{"abstract":"Effects of variations in agent, dose, and route of treatment administration on patient reported quality of life (QOL) were examined for 279 patients enrolled on a seven-arm randomized clinical trial (S8905) of 5-FU and its modulation for advanced colorectal cancer. Patients completed QOL questionnaires at randomization and weeks 6, 11, and 21 post-randomization with five QOL endpoints considered primary: three treatment-specific symptoms (stomatitis, diarrhea, and hand/foot sensitivity); physical functioning; and emotional functioning. Patient compliance with the QOL assessment schedule was good, supporting the feasibility of including QOL measures in cooperative group trials. However, death and deteriorating health produced substantial missing data. Cross-sectional analyses indicated that the seven therapeutic arms did not differ in their impact on QOL. Unfortunately, longitudinal analyses of the QOL data were inappropriate given non-random missing data. Graphical presentation of non-random missing data identified the seriousness of this problem and its effect on potential conclusions about QOL during treatment. This problem appears to be particularly challenging in the context of advanced-stage disease. Failure to recognize the presence of non-random missing data can lead to serious overestimates of patient QOL over time.","publication_date":{"day":null,"month":null,"year":2000,"errors":{}},"publication_name":"Psycho‐Oncology"},"translated_abstract":"Effects of variations in agent, dose, and route of treatment administration on patient reported quality of life (QOL) were examined for 279 patients enrolled on a seven-arm randomized clinical trial (S8905) of 5-FU and its modulation for advanced colorectal cancer. Patients completed QOL questionnaires at randomization and weeks 6, 11, and 21 post-randomization with five QOL endpoints considered primary: three treatment-specific symptoms (stomatitis, diarrhea, and hand/foot sensitivity); physical functioning; and emotional functioning. Patient compliance with the QOL assessment schedule was good, supporting the feasibility of including QOL measures in cooperative group trials. However, death and deteriorating health produced substantial missing data. Cross-sectional analyses indicated that the seven therapeutic arms did not differ in their impact on QOL. Unfortunately, longitudinal analyses of the QOL data were inappropriate given non-random missing data. Graphical presentation of non-random missing data identified the seriousness of this problem and its effect on potential conclusions about QOL during treatment. This problem appears to be particularly challenging in the context of advanced-stage disease. Failure to recognize the presence of non-random missing data can lead to serious overestimates of patient QOL over time.","internal_url":"https://www.academia.edu/19323999/Challenges_posed_by_non_random_missing_quality_of_life_data_in_an_advanced_stage_colorectal_cancer_clinical_trial","translated_internal_url":"","created_at":"2015-12-01T15:09:40.075-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452408,"work_id":19323999,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688052,"email":"m***1@gcrc.med.nyu.edu","display_order":0,"name":"Franco Muggia","title":"Challenges posed by non‐random missing quality of life data in an advanced‐stage colorectal cancer clinical trial"}],"downloadable_attachments":[],"slug":"Challenges_posed_by_non_random_missing_quality_of_life_data_in_an_advanced_stage_colorectal_cancer_clinical_trial","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39578858,"first_name":"Frank","middle_initials":null,"last_name":"Meyskens","page_name":"FrankMeyskens","domain_name":"independent","created_at":"2015-12-01T15:09:08.450-08:00","display_name":"Frank Meyskens","url":"https://independent.academia.edu/FrankMeyskens"},"attachments":[],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design"},{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial"},{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life"},{"id":37292,"name":"Colorectal cancer","url":"https://www.academia.edu/Documents/in/Colorectal_cancer"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":93443,"name":"Psycho","url":"https://www.academia.edu/Documents/in/Psycho"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":135265,"name":"Psycho Oncology","url":"https://www.academia.edu/Documents/in/Psycho_Oncology"},{"id":153168,"name":"Data Collection","url":"https://www.academia.edu/Documents/in/Data_Collection"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires"},{"id":330953,"name":"Longitudinal Studies","url":"https://www.academia.edu/Documents/in/Longitudinal_Studies"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results"},{"id":936874,"name":"Bias (Epidemiology)","url":"https://www.academia.edu/Documents/in/Bias_Epidemiology_"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19323998"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19323998/Melanin_as_a_Target_for_Melanoma_Chemotherapy_Pro_oxidant_Effect_of_Oxygen_and_Metals_on_Melanoma_Viability"><img alt="Research paper thumbnail of Melanin as a Target for Melanoma Chemotherapy: Pro-oxidant Effect of Oxygen and Metals on Melanoma Viability" class="work-thumbnail" src="https://attachments.academia-assets.com/40556354/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323998/Melanin_as_a_Target_for_Melanoma_Chemotherapy_Pro_oxidant_Effect_of_Oxygen_and_Metals_on_Melanoma_Viability">Melanin as a Target for Melanoma Chemotherapy: Pro-oxidant Effect of Oxygen and Metals on Melanoma Viability</a></div><div class="wp-workCard_item"><span>Pigment Cell Research</span><span>, 2003</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="15730d6f456927141694259217bee18f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":40556354,"asset_id":19323998,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/40556354/download_file?st=MTczMjQzMzc0Miw4LjIyMi4yMDguMTQ2&st=MTczMjQzMzc0MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323998"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323998"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323998; 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We hypothesize that disorganization of the melanosomes will allow chemical targeting of the melanin within. Chemical studies show that under oxidative conditions, synthetic melanins demonstrate increased metal affinity and a susceptibility to redox cycling with oxygen to form reactive oxygen species. The electron paramagnetic resonance (EPR)active 5,5¢-dimethyl-pyrollidine N-oxide spin adduct was used to show that binding of divalent Zn or Cu to melanin induces a pro-oxidant response under oxygen, generating superoxide and hydroxyl radicals. A similar pro-oxidant behaviour is seen in melanoma cell lines under external peroxide stress. Melanoma cultures grown under 95% O 2 ⁄5% CO 2 atmospheres show markedly reduced viability as compared with normal melanocytes. Cu-and Zn-dithiocarbamate complexes, which induce passive uptake of the metal ions into cells, show significant antimelanoma activity. 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papillomavirus infection and number of lifetime sexual partners are strong predictors for natural regression of cervical intraepithelial neoplasia 2 and 3" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323997/Human_papillomavirus_infection_and_number_of_lifetime_sexual_partners_are_strong_predictors_for_natural_regression_of_cervical_intraepithelial_neoplasia_2_and_3">Human papillomavirus infection and number of lifetime sexual partners are strong predictors for natural regression of cervical intraepithelial neoplasia 2 and 3</a></div><div class="wp-workCard_item"><span>Obstetrics & Gynecology</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323997"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323997"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323997; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19323997]").text(description); $(".js-view-count[data-work-id=19323997]").attr('title', description).tooltip(); }); 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As drugs are developed to address these targets, there is a need for high-throughput systems that accurately reproduce in vivo microenvironments to gauge their efficacy. Accordingly, we have developed a three-dimensional in vitro culture system representative of the environment present upon secondary metastasis to quantitatively measure tumor cell invasion in this setting three-dimensionally. Culturing melanomas of different metastatic capacities within the system showed that each cell type invades the matrix in a manner commensurate to its known metastatic potential in vivo. Moreover, the developed quantitative schemes were put to use to characterize the effect of microenvironmental influences (i.e., matrix components, interstitial cell presence) on planar and vertical melanoma invasion. We propose this novel, quantitative system as a useful tool to assess the effects of pharmacologic and/or microenvironmental influences on tumor cell invasion at a metastatic site.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323996"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323996"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323996; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19323996]").text(description); $(".js-view-count[data-work-id=19323996]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19323996; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19323996']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19323996, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19323996]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19323996,"title":"A novel three-dimensional model to quantify metastatic melanoma invasion","translated_title":"","metadata":{"abstract":"Although attempts to develop any viable chemotherapeutic approaches to combat metastatic cancers have largely failed, potential genetic targets to halt metastatic progression continue to be identified. 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We propose this novel, quantitative system as a useful tool to assess the effects of pharmacologic and/or microenvironmental influences on tumor cell invasion at a metastatic site.","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Molecular Cancer Therapeutics"},"translated_abstract":"Although attempts to develop any viable chemotherapeutic approaches to combat metastatic cancers have largely failed, potential genetic targets to halt metastatic progression continue to be identified. As drugs are developed to address these targets, there is a need for high-throughput systems that accurately reproduce in vivo microenvironments to gauge their efficacy. Accordingly, we have developed a three-dimensional in vitro culture system representative of the environment present upon secondary metastasis to quantitatively measure tumor cell invasion in this setting three-dimensionally. Culturing melanomas of different metastatic capacities within the system showed that each cell type invades the matrix in a manner commensurate to its known metastatic potential in vivo. Moreover, the developed quantitative schemes were put to use to characterize the effect of microenvironmental influences (i.e., matrix components, interstitial cell presence) on planar and vertical melanoma invasion. We propose this novel, quantitative system as a useful tool to assess the effects of pharmacologic and/or microenvironmental influences on tumor cell invasion at a metastatic site.","internal_url":"https://www.academia.edu/19323996/A_novel_three_dimensional_model_to_quantify_metastatic_melanoma_invasion","translated_internal_url":"","created_at":"2015-12-01T15:09:39.733-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452495,"work_id":19323996,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688084,"email":"c***r@fhcrc.org","display_order":0,"name":"C. Ghajar","title":"A novel three-dimensional model to quantify metastatic melanoma invasion"},{"id":11452496,"work_id":19323996,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688085,"email":"s***n@mit.edu","display_order":4194304,"name":"S. Peyton","title":"A novel three-dimensional model to quantify metastatic melanoma invasion"},{"id":11452497,"work_id":19323996,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688086,"email":"r***b@gwmail.gwu.edu","display_order":6291456,"name":"C. Raub","title":"A novel three-dimensional model to quantify metastatic melanoma invasion"}],"downloadable_attachments":[],"slug":"A_novel_three_dimensional_model_to_quantify_metastatic_melanoma_invasion","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39578858,"first_name":"Frank","middle_initials":null,"last_name":"Meyskens","page_name":"FrankMeyskens","domain_name":"independent","created_at":"2015-12-01T15:09:08.450-08:00","display_name":"Frank Meyskens","url":"https://independent.academia.edu/FrankMeyskens"},"attachments":[],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":29149,"name":"Extracellular Matrix","url":"https://www.academia.edu/Documents/in/Extracellular_Matrix"},{"id":46992,"name":"Molecular Biology Cancer","url":"https://www.academia.edu/Documents/in/Molecular_Biology_Cancer"},{"id":61095,"name":"Fibrin","url":"https://www.academia.edu/Documents/in/Fibrin"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":79808,"name":"Collagen","url":"https://www.academia.edu/Documents/in/Collagen"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":209510,"name":"Epidermis","url":"https://www.academia.edu/Documents/in/Epidermis"},{"id":371494,"name":"Neoplasm Invasiveness","url":"https://www.academia.edu/Documents/in/Neoplasm_Invasiveness"},{"id":413750,"name":"In vitro culture","url":"https://www.academia.edu/Documents/in/In_vitro_culture"},{"id":459378,"name":"Very high throughput","url":"https://www.academia.edu/Documents/in/Very_high_throughput"},{"id":504035,"name":"Three Dimensional","url":"https://www.academia.edu/Documents/in/Three_Dimensional"},{"id":787715,"name":"Molecular Cancer Therapeutics","url":"https://www.academia.edu/Documents/in/Molecular_Cancer_Therapeutics"},{"id":2177223,"name":"Skin Neoplasms","url":"https://www.academia.edu/Documents/in/Skin_Neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19323995"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19323995/Development_and_characteristics_of_a_human_cell_assay_for_screening_agents_for_melanoma_prevention"><img alt="Research paper thumbnail of Development and characteristics of a human cell assay for screening agents for melanoma prevention" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323995/Development_and_characteristics_of_a_human_cell_assay_for_screening_agents_for_melanoma_prevention">Development and characteristics of a human cell assay for screening agents for melanoma prevention</a></div><div class="wp-workCard_item"><span>Melanoma Research</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This paper describes the development and initial evaluation of a human cell assay to identify pot...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This paper describes the development and initial evaluation of a human cell assay to identify potentially efficacious agents for preventing melanoma. Four human cell lines were used: normal melanocytes, a radial growth-phase-like melanoma cell line (WM3211), a vertical growth-phase-like melanoma cell line (Lu1205), and 83-2c, a cell strain cloned from metastatic melanoma. Four endpoints were evaluated in ultraviolet B-treated cells: annexin V, human leukocyte antigen-DR; E-cadherin, and N-cadherin. Annexin V was induced by nimesulide, 4-hydroxyphenylretinamide, and difluoromethylornithine in ultraviolet-B-treated radial growth-phase-like melanoma cells. None of the agents inhibited human leukocyte antigen-DR expression in ultraviolet-B-treated radial growth-phase-like melanoma cells, the only cells that strongly expressed human leukocyte antigen-DR. E-cadherin was overexpressed only in radial growth-phase-like melanoma cells relative to melanocytes, and ultraviolet B exposure dramatically reduced this expression. E-cadherin was only induced by difluoromethylornithine in ultraviolet-B-treated radial growth-phase-like melanoma cells. N-cadherin was over- expressed in all melanoma cell lines relative to melanocytes. In this study, all candidate preventive agents inhibited N-cadherin in ultraviolet B-treated radial growth-phase-like melanoma cells. Four agents inhibited N-cadherin in ultraviolet B-treated vertical growth-phase-like melanoma cells. The mean ratios of N-cadherin to E-cadherin levels and specific endpoint responses for both the radial growth-phase-like melanoma and vertical growth-phase-like melanoma cells were used to rank the agents. Agents were evaluated at clinically relevant concentrations. The rankings were difluoromethylornithine&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;4-hydroxyphenylretinamide&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;nimesulide&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;9-cis-retinoic acid&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;polyphenon E. Diphenylhydramine, D-mannitol, and nordihydroguaiaretic acid were inactive. The results of these initial studies suggest that ultraviolet-B-treated radial growth-phase-like melanoma cells are the most responsive to chemopreventive agents, and may be the cell line of choice for screening melanoma prevention agents.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323995"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323995"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323995; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19323995]").text(description); $(".js-view-count[data-work-id=19323995]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19323995; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19323995']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19323995, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19323995]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19323995,"title":"Development and characteristics of a human cell assay for screening agents for melanoma prevention","translated_title":"","metadata":{"abstract":"This paper describes the development and initial evaluation of a human cell assay to identify potentially efficacious agents for preventing melanoma. Four human cell lines were used: normal melanocytes, a radial growth-phase-like melanoma cell line (WM3211), a vertical growth-phase-like melanoma cell line (Lu1205), and 83-2c, a cell strain cloned from metastatic melanoma. Four endpoints were evaluated in ultraviolet B-treated cells: annexin V, human leukocyte antigen-DR; E-cadherin, and N-cadherin. Annexin V was induced by nimesulide, 4-hydroxyphenylretinamide, and difluoromethylornithine in ultraviolet-B-treated radial growth-phase-like melanoma cells. None of the agents inhibited human leukocyte antigen-DR expression in ultraviolet-B-treated radial growth-phase-like melanoma cells, the only cells that strongly expressed human leukocyte antigen-DR. E-cadherin was overexpressed only in radial growth-phase-like melanoma cells relative to melanocytes, and ultraviolet B exposure dramatically reduced this expression. E-cadherin was only induced by difluoromethylornithine in ultraviolet-B-treated radial growth-phase-like melanoma cells. N-cadherin was over- expressed in all melanoma cell lines relative to melanocytes. In this study, all candidate preventive agents inhibited N-cadherin in ultraviolet B-treated radial growth-phase-like melanoma cells. Four agents inhibited N-cadherin in ultraviolet B-treated vertical growth-phase-like melanoma cells. The mean ratios of N-cadherin to E-cadherin levels and specific endpoint responses for both the radial growth-phase-like melanoma and vertical growth-phase-like melanoma cells were used to rank the agents. Agents were evaluated at clinically relevant concentrations. The rankings were difluoromethylornithine\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;4-hydroxyphenylretinamide\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;nimesulide\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;9-cis-retinoic acid\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;polyphenon E. Diphenylhydramine, D-mannitol, and nordihydroguaiaretic acid were inactive. The results of these initial studies suggest that ultraviolet-B-treated radial growth-phase-like melanoma cells are the most responsive to chemopreventive agents, and may be the cell line of choice for screening melanoma prevention agents.","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Melanoma Research"},"translated_abstract":"This paper describes the development and initial evaluation of a human cell assay to identify potentially efficacious agents for preventing melanoma. Four human cell lines were used: normal melanocytes, a radial growth-phase-like melanoma cell line (WM3211), a vertical growth-phase-like melanoma cell line (Lu1205), and 83-2c, a cell strain cloned from metastatic melanoma. Four endpoints were evaluated in ultraviolet B-treated cells: annexin V, human leukocyte antigen-DR; E-cadherin, and N-cadherin. Annexin V was induced by nimesulide, 4-hydroxyphenylretinamide, and difluoromethylornithine in ultraviolet-B-treated radial growth-phase-like melanoma cells. None of the agents inhibited human leukocyte antigen-DR expression in ultraviolet-B-treated radial growth-phase-like melanoma cells, the only cells that strongly expressed human leukocyte antigen-DR. E-cadherin was overexpressed only in radial growth-phase-like melanoma cells relative to melanocytes, and ultraviolet B exposure dramatically reduced this expression. E-cadherin was only induced by difluoromethylornithine in ultraviolet-B-treated radial growth-phase-like melanoma cells. N-cadherin was over- expressed in all melanoma cell lines relative to melanocytes. In this study, all candidate preventive agents inhibited N-cadherin in ultraviolet B-treated radial growth-phase-like melanoma cells. Four agents inhibited N-cadherin in ultraviolet B-treated vertical growth-phase-like melanoma cells. The mean ratios of N-cadherin to E-cadherin levels and specific endpoint responses for both the radial growth-phase-like melanoma and vertical growth-phase-like melanoma cells were used to rank the agents. Agents were evaluated at clinically relevant concentrations. The rankings were difluoromethylornithine\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;4-hydroxyphenylretinamide\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;nimesulide\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;9-cis-retinoic acid\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;polyphenon E. Diphenylhydramine, D-mannitol, and nordihydroguaiaretic acid were inactive. The results of these initial studies suggest that ultraviolet-B-treated radial growth-phase-like melanoma cells are the most responsive to chemopreventive agents, and may be the cell line of choice for screening melanoma prevention agents.","internal_url":"https://www.academia.edu/19323995/Development_and_characteristics_of_a_human_cell_assay_for_screening_agents_for_melanoma_prevention","translated_internal_url":"","created_at":"2015-12-01T15:09:39.625-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452477,"work_id":19323995,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688073,"email":"a***j@hs.uci.edu","display_order":0,"name":"Aarti Jain","title":"Development and characteristics of a human cell assay for screening agents for melanoma prevention"},{"id":11452478,"work_id":19323995,"tagging_user_id":39578858,"tagged_user_id":278482955,"co_author_invite_id":2688074,"email":"s***a@gmail.com","display_order":4194304,"name":"Shazia Siddiqi","title":"Development and characteristics of a human cell assay for screening agents for melanoma prevention"}],"downloadable_attachments":[],"slug":"Development_and_characteristics_of_a_human_cell_assay_for_screening_agents_for_melanoma_prevention","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39578858,"first_name":"Frank","middle_initials":null,"last_name":"Meyskens","page_name":"FrankMeyskens","domain_name":"independent","created_at":"2015-12-01T15:09:08.450-08:00","display_name":"Frank Meyskens","url":"https://independent.academia.edu/FrankMeyskens"},"attachments":[],"research_interests":[{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant"},{"id":346418,"name":"Foreskin","url":"https://www.academia.edu/Documents/in/Foreskin"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results"},{"id":701219,"name":"Melanocytes","url":"https://www.academia.edu/Documents/in/Melanocytes"},{"id":2177223,"name":"Skin Neoplasms","url":"https://www.academia.edu/Documents/in/Skin_Neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19323994"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19323994/An_Exploratory_Study_of_Attitudes_Beliefs_and_Practices_Related_to_the_Interim_Dietary_Guidelines_for_Reducing_Cancer_in_the_Elderly"><img alt="Research paper thumbnail of An Exploratory Study of Attitudes, Beliefs and Practices Related to the Interim Dietary Guidelines for Reducing Cancer in the Elderly" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323994/An_Exploratory_Study_of_Attitudes_Beliefs_and_Practices_Related_to_the_Interim_Dietary_Guidelines_for_Reducing_Cancer_in_the_Elderly">An Exploratory Study of Attitudes, Beliefs and Practices Related to the Interim Dietary Guidelines for Reducing Cancer in the Elderly</a></div><div class="wp-workCard_item"><span>Journal of Nutrition For the Elderly</span><span>, 1991</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In this pilot study, a self-administered questionnaire was used to assess the health attitudes, b...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this pilot study, a self-administered questionnaire was used to assess the health attitudes, beliefs and practices related to each of the Interim Dietary Guidelines for Reducing Cancer Risk (I.D.G.R.C.R.) in a convenience sample of elderly Caucasian subjects (N = 30) over 60 years old. The questionnaire items included personal efficacy, perceived motivators and barriers, and current practices related to the compliance of each of the dietary guidelines. The distributions of responses to the questionnaire items show variations in the subjects&amp;#39; attitudes, beliefs and current dietary practices related to each of the dietary guidelines. Most subjects reported current practice of most guidelines except the guideline of a low fat diet. Most of the time, the subjects perceived one or more motivations to comply with the guidelines of eating fruits and vegetables high in vitamin C, and eating dark green or deep yellow vegetables. Taste and health benefits were shown to be important factors among motivators influencing the compliance to the dietary guidelines. The findings of this exploratory study have direct implications for planning nutrition intervention programs for cancer risk reduction in the elderly.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323994"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323994"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323994; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19323994]").text(description); $(".js-view-count[data-work-id=19323994]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19323994; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19323994']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19323994, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19323994]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19323994,"title":"An Exploratory Study of Attitudes, Beliefs and Practices Related to the Interim Dietary Guidelines for Reducing Cancer in the Elderly","translated_title":"","metadata":{"abstract":"In this pilot study, a self-administered questionnaire was used to assess the health attitudes, beliefs and practices related to each of the Interim Dietary Guidelines for Reducing Cancer Risk (I.D.G.R.C.R.) in a convenience sample of elderly Caucasian subjects (N = 30) over 60 years old. The questionnaire items included personal efficacy, perceived motivators and barriers, and current practices related to the compliance of each of the dietary guidelines. The distributions of responses to the questionnaire items show variations in the subjects\u0026amp;#39; attitudes, beliefs and current dietary practices related to each of the dietary guidelines. Most subjects reported current practice of most guidelines except the guideline of a low fat diet. Most of the time, the subjects perceived one or more motivations to comply with the guidelines of eating fruits and vegetables high in vitamin C, and eating dark green or deep yellow vegetables. Taste and health benefits were shown to be important factors among motivators influencing the compliance to the dietary guidelines. The findings of this exploratory study have direct implications for planning nutrition intervention programs for cancer risk reduction in the elderly.","publication_date":{"day":null,"month":null,"year":1991,"errors":{}},"publication_name":"Journal of Nutrition For the Elderly"},"translated_abstract":"In this pilot study, a self-administered questionnaire was used to assess the health attitudes, beliefs and practices related to each of the Interim Dietary Guidelines for Reducing Cancer Risk (I.D.G.R.C.R.) in a convenience sample of elderly Caucasian subjects (N = 30) over 60 years old. The questionnaire items included personal efficacy, perceived motivators and barriers, and current practices related to the compliance of each of the dietary guidelines. The distributions of responses to the questionnaire items show variations in the subjects\u0026amp;#39; attitudes, beliefs and current dietary practices related to each of the dietary guidelines. Most subjects reported current practice of most guidelines except the guideline of a low fat diet. Most of the time, the subjects perceived one or more motivations to comply with the guidelines of eating fruits and vegetables high in vitamin C, and eating dark green or deep yellow vegetables. Taste and health benefits were shown to be important factors among motivators influencing the compliance to the dietary guidelines. The findings of this exploratory study have direct implications for planning nutrition intervention programs for cancer risk reduction in the elderly.","internal_url":"https://www.academia.edu/19323994/An_Exploratory_Study_of_Attitudes_Beliefs_and_Practices_Related_to_the_Interim_Dietary_Guidelines_for_Reducing_Cancer_in_the_Elderly","translated_internal_url":"","created_at":"2015-12-01T15:09:39.519-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452417,"work_id":19323994,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688057,"email":"e***g@gmail.com","display_order":0,"name":"E. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19323992"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19323992/Effects_of_Dietary_Wheat_Bran_Fiber_on_Rectal_Epithelial_Cell_Proliferation_in_Patients_With_Research_for_Colorectal_Cancers"><img alt="Research paper thumbnail of Effects of Dietary Wheat Bran Fiber on Rectal Epithelial Cell Proliferation in Patients With Research for Colorectal Cancers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323992/Effects_of_Dietary_Wheat_Bran_Fiber_on_Rectal_Epithelial_Cell_Proliferation_in_Patients_With_Research_for_Colorectal_Cancers">Effects of Dietary Wheat Bran Fiber on Rectal Epithelial Cell Proliferation in Patients With Research for Colorectal Cancers</a></div><div class="wp-workCard_item"><span>JNCI Journal of the National Cancer Institute</span><span>, 1990</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A preponderance of carcinogenesis studies in rodents and epidemiologic studies in humans suggests...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A preponderance of carcinogenesis studies in rodents and epidemiologic studies in humans suggests a potential role of dietary fiber in the prevention of colorectal cancer. Recently, wheat bran fiber used as a dietary supplement has been shown to decrease the growth of rectal adenomatous polyps in patients with familial polyposis; however, few studies of high-risk human populations have been attempted to determine the effects of dietary fiber supplementation on markers of carcinogenesis in the colon or rectum. We have designed a one-arm study to evaluate the effects of dietary supplementation with wheat bran fiber [i.e., 13.5 g/day for 8 wk; after 1 mo, 2 g/day (compliance evaluation period)] on [3H]thymidine rectal mucosa cell labeling (i.e., percent of epithelial cells incorporating [3H]thymidine into DNA in intact rectal crypt cells over a 90-min exposure as well as in minced rectal biopsy tissue over a 24-hr exposure) in rectal biopsy specimens. The biopsy specimens were obtained at sigmoidoscopy in 17 compliant patients with a history of resected colon or rectal cancer. We categorized patients as having initially low or initially high [3H]thymidine-labeling indices (i.e., percent of mucosa cells that incorporate [3H]thymidine into DNA during 1.5- or 24-hour in vitro incubations) by using the median baseline labeling index as a cutoff between high and low values. On the basis of a chi-square test used to identify patients with a statistically significant (P less than .001) change, six of the eight patients who initially had high 24-hour outgrowth labeling indices showed a significant decrease in the rectal mucosa biopsy specimens obtained after treatment. An overall 22% decrease was observed in rectal mucosa cell biopsy specimens obtained at study termination (P less than .001). Of the eight patients with initially high total [3H]thymidine-labeling indices in crypt organ culture, four had a significant (P less than .001) decrease from baseline values, one had a significant increase, and three showed no change following the fiber intervention. The wheat bran fiber dietary supplement of 13.5 g/day was well tolerated by this group of older (54-70 yr) patients. Although the [3H]-thymidine labeling index data suggest that the wheat bran fiber supplement can inhibit DNA synthesis and rectal mucosa cell proliferation in high-risk patients, the results of this small pilot study should not be overinterpreted vis à vis the potential role of wheat bran fiber as a chemopreventive agent for colorectal cancer.(ABSTRACT TRUNCATED AT 400 WORDS)</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323992"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323992"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323992; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19323992]").text(description); $(".js-view-count[data-work-id=19323992]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19323992; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19323992']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19323992, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19323992]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19323992,"title":"Effects of Dietary Wheat Bran Fiber on Rectal Epithelial Cell Proliferation in Patients With Research for Colorectal Cancers","translated_title":"","metadata":{"abstract":"A preponderance of carcinogenesis studies in rodents and epidemiologic studies in humans suggests a potential role of dietary fiber in the prevention of colorectal cancer. 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We categorized patients as having initially low or initially high [3H]thymidine-labeling indices (i.e., percent of mucosa cells that incorporate [3H]thymidine into DNA during 1.5- or 24-hour in vitro incubations) by using the median baseline labeling index as a cutoff between high and low values. On the basis of a chi-square test used to identify patients with a statistically significant (P less than .001) change, six of the eight patients who initially had high 24-hour outgrowth labeling indices showed a significant decrease in the rectal mucosa biopsy specimens obtained after treatment. An overall 22% decrease was observed in rectal mucosa cell biopsy specimens obtained at study termination (P less than .001). Of the eight patients with initially high total [3H]thymidine-labeling indices in crypt organ culture, four had a significant (P less than .001) decrease from baseline values, one had a significant increase, and three showed no change following the fiber intervention. 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We categorized patients as having initially low or initially high [3H]thymidine-labeling indices (i.e., percent of mucosa cells that incorporate [3H]thymidine into DNA during 1.5- or 24-hour in vitro incubations) by using the median baseline labeling index as a cutoff between high and low values. On the basis of a chi-square test used to identify patients with a statistically significant (P less than .001) change, six of the eight patients who initially had high 24-hour outgrowth labeling indices showed a significant decrease in the rectal mucosa biopsy specimens obtained after treatment. An overall 22% decrease was observed in rectal mucosa cell biopsy specimens obtained at study termination (P less than .001). Of the eight patients with initially high total [3H]thymidine-labeling indices in crypt organ culture, four had a significant (P less than .001) decrease from baseline values, one had a significant increase, and three showed no change following the fiber intervention. 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Although the [3H]-thymidine labeling index data suggest that the wheat bran fiber supplement can inhibit DNA synthesis and rectal mucosa cell proliferation in high-risk patients, the results of this small pilot study should not be overinterpreted vis à vis the potential role of wheat bran fiber as a chemopreventive agent for colorectal cancer.(ABSTRACT TRUNCATED AT 400 WORDS)","internal_url":"https://www.academia.edu/19323992/Effects_of_Dietary_Wheat_Bran_Fiber_on_Rectal_Epithelial_Cell_Proliferation_in_Patients_With_Research_for_Colorectal_Cancers","translated_internal_url":"","created_at":"2015-12-01T15:09:39.296-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452396,"work_id":19323992,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688043,"email":"m***r@ucollege.edu","display_order":0,"name":"M. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19323991"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19323991/Quality_of_Life_in_Advanced_Prostate_Cancer_Results_of_a_Randomized_Therapeutic_Trial"><img alt="Research paper thumbnail of Quality of Life in Advanced Prostate Cancer: Results of a Randomized Therapeutic Trial" class="work-thumbnail" src="https://attachments.academia-assets.com/40556358/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323991/Quality_of_Life_in_Advanced_Prostate_Cancer_Results_of_a_Randomized_Therapeutic_Trial">Quality of Life in Advanced Prostate Cancer: Results of a Randomized Therapeutic Trial</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FrankMeyskens">Frank Meyskens</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MarioEisenberger">Mario Eisenberger</a></span></div><div class="wp-workCard_item"><span>JNCI Journal of the National Cancer Institute</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a71d40dd4f1555d1d9d8f2b0e32d937b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":40556358,"asset_id":19323991,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/40556358/download_file?st=MTczMjQzMzc0Miw4LjIyMi4yMDguMTQ2&st=MTczMjQzMzc0MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323991"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323991"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323991; 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To help document the achievement of palliation and to characterize positive and negative effects of treatment, we evaluated qualityof-life (QOL) parameters in patients with metastatic prostate cancer who were randomly assigned to two methods of androgen deprivation. Methods: Patients (n = 739) with stage M 1 (bone or soft tissue metastasis) prostate cancer were enrolled in a QOL protocol that was a companion to Southwest Oncology Group INT-0105, a randomized doubleblind trial comparing treatment with bilateral orchiectomy (surgical castration) plus either flutamide or placebo. Patients completed a comprehensive battery of QOL questionnaires at random assignment to treatment and at 1, 3, and 6 months later. Data were collected on three treatment-specific symptoms (diarrhea, gas pain, and body image), on physical functioning, and on emotional functioning. All P values are two-sided. Results: Questionnaire return rates for this study never dropped below 80%; only 2% of the patients did not submit baseline QOL assessments. Cross-sectional analyses (corrected for multiple testing) identified statistically significant differences that favored orchiectomy plus placebo for two of the five primary QOL parameters as follows: patients receiving flutamide reported more diarrhea at 3 months (P = .001) and worse emotional functioning at 3 and 6 months (both P\u003c.003). Longitudinal analyses replicated these findings. Other analyzed QOL parameters favored the group receiving placebo but were not statistically significant after adjustment for multiple testing. Conclusions: We found a consistent pattern of better QOL outcomes at each follow-up assessment during the first 6 months of treatment for orchiectomized patients with metastatic prostate cancer who received placebo versus flutamide. Improvement over time was evident in both treatment groups but more so for patients receiving placebo. [J Natl Cancer Inst 1998;90:1537-44]","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"JNCI Journal of the National Cancer Institute","grobid_abstract_attachment_id":40556358},"translated_abstract":null,"internal_url":"https://www.academia.edu/19323991/Quality_of_Life_in_Advanced_Prostate_Cancer_Results_of_a_Randomized_Therapeutic_Trial","translated_internal_url":"","created_at":"2015-12-01T15:09:39.194-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452371,"work_id":19323991,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688035,"email":"e***d@uiowa.edu","display_order":0,"name":"E. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19323990"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19323990/Effect_of_Difluoromethylornithine_on_Rectal_Mucosal_Levels_of_Polyamines_in_a_Randomized_Double_Blinded_Trial_for_Colon_Cancer_Prevention"><img alt="Research paper thumbnail of Effect of -Difluoromethylornithine on Rectal Mucosal Levels of Polyamines in a Randomized, Double-Blinded Trial for Colon Cancer Prevention" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323990/Effect_of_Difluoromethylornithine_on_Rectal_Mucosal_Levels_of_Polyamines_in_a_Randomized_Double_Blinded_Trial_for_Colon_Cancer_Prevention">Effect of -Difluoromethylornithine on Rectal Mucosal Levels of Polyamines in a Randomized, Double-Blinded Trial for Colon Cancer Prevention</a></div><div class="wp-workCard_item"><span>JNCI Journal of the National Cancer Institute</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Polyamines (e.g., putrescine, spermidine, and spermine) are required for optimal cell growth. Inh...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Polyamines (e.g., putrescine, spermidine, and spermine) are required for optimal cell growth. Inhibition of polyamine synthesis suppresses carcinogen-induced epithelial cancers, including colon cancer, in animal models. In a short-term phase IIa trial, we determined that low doses of alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (an enzyme involved in polyamine synthesis), reduced the polyamine content of normal-appearing rectal mucosa of subjects with a prior history of resected colon polyps. In a follow-up study, we have attempted to determine the lowest dose of DFMO that can suppress the polyamine content of rectal mucosa over a course of 1 year with no or minimal side effects. Participants were randomly assigned to daily oral treatment with a placebo or one of three doses (0.075, 0.20, or 0.40 g/m2) of DFMO. Baseline and serial determinations of polyamine levels in rectal mucosa and extensive symptom monitoring (including audiometric measurements, since DFMO causes some reversible hearing loss at higher doses) were performed over a 15-month period. DFMO treatment reduced putrescine levels in a dose-dependent manner. Following 6 months of treatment, doses of 0.20 and 0.40 g/m2 per day reduced putrescine levels to approximately 34% and 10%, respectively, of those observed in the placebo group. Smaller decreases were seen in spermidine levels and spermidine:spermine ratios. Polyamine levels increased toward baseline values after discontinuation of DFMO. Although there were no statistically significant differences among the dose groups with respect to clinically important shifts in audiometric thresholds and nonaudiologic side effects, statistically significant higher dropout and discontinuation rates were observed in the highest dose group. Polyamine levels in rectal mucosa can be continuously suppressed by daily oral doses of DFMO that produce few or no side effects. A dose of 0.20 g/m2 can be used safely in combination phase IIb or single-agent phase III chemoprevention trials.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323990"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323990"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323990; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19323990]").text(description); $(".js-view-count[data-work-id=19323990]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19323990; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19323990']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19323990, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19323990]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19323990,"title":"Effect of -Difluoromethylornithine on Rectal Mucosal Levels of Polyamines in a Randomized, Double-Blinded Trial for Colon Cancer Prevention","translated_title":"","metadata":{"abstract":"Polyamines (e.g., putrescine, spermidine, and spermine) are required for optimal cell growth. Inhibition of polyamine synthesis suppresses carcinogen-induced epithelial cancers, including colon cancer, in animal models. In a short-term phase IIa trial, we determined that low doses of alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (an enzyme involved in polyamine synthesis), reduced the polyamine content of normal-appearing rectal mucosa of subjects with a prior history of resected colon polyps. In a follow-up study, we have attempted to determine the lowest dose of DFMO that can suppress the polyamine content of rectal mucosa over a course of 1 year with no or minimal side effects. Participants were randomly assigned to daily oral treatment with a placebo or one of three doses (0.075, 0.20, or 0.40 g/m2) of DFMO. Baseline and serial determinations of polyamine levels in rectal mucosa and extensive symptom monitoring (including audiometric measurements, since DFMO causes some reversible hearing loss at higher doses) were performed over a 15-month period. DFMO treatment reduced putrescine levels in a dose-dependent manner. Following 6 months of treatment, doses of 0.20 and 0.40 g/m2 per day reduced putrescine levels to approximately 34% and 10%, respectively, of those observed in the placebo group. Smaller decreases were seen in spermidine levels and spermidine:spermine ratios. Polyamine levels increased toward baseline values after discontinuation of DFMO. Although there were no statistically significant differences among the dose groups with respect to clinically important shifts in audiometric thresholds and nonaudiologic side effects, statistically significant higher dropout and discontinuation rates were observed in the highest dose group. Polyamine levels in rectal mucosa can be continuously suppressed by daily oral doses of DFMO that produce few or no side effects. A dose of 0.20 g/m2 can be used safely in combination phase IIb or single-agent phase III chemoprevention trials.","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"JNCI Journal of the National Cancer Institute"},"translated_abstract":"Polyamines (e.g., putrescine, spermidine, and spermine) are required for optimal cell growth. Inhibition of polyamine synthesis suppresses carcinogen-induced epithelial cancers, including colon cancer, in animal models. In a short-term phase IIa trial, we determined that low doses of alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (an enzyme involved in polyamine synthesis), reduced the polyamine content of normal-appearing rectal mucosa of subjects with a prior history of resected colon polyps. In a follow-up study, we have attempted to determine the lowest dose of DFMO that can suppress the polyamine content of rectal mucosa over a course of 1 year with no or minimal side effects. Participants were randomly assigned to daily oral treatment with a placebo or one of three doses (0.075, 0.20, or 0.40 g/m2) of DFMO. Baseline and serial determinations of polyamine levels in rectal mucosa and extensive symptom monitoring (including audiometric measurements, since DFMO causes some reversible hearing loss at higher doses) were performed over a 15-month period. DFMO treatment reduced putrescine levels in a dose-dependent manner. Following 6 months of treatment, doses of 0.20 and 0.40 g/m2 per day reduced putrescine levels to approximately 34% and 10%, respectively, of those observed in the placebo group. Smaller decreases were seen in spermidine levels and spermidine:spermine ratios. Polyamine levels increased toward baseline values after discontinuation of DFMO. Although there were no statistically significant differences among the dose groups with respect to clinically important shifts in audiometric thresholds and nonaudiologic side effects, statistically significant higher dropout and discontinuation rates were observed in the highest dose group. Polyamine levels in rectal mucosa can be continuously suppressed by daily oral doses of DFMO that produce few or no side effects. A dose of 0.20 g/m2 can be used safely in combination phase IIb or single-agent phase III chemoprevention trials.","internal_url":"https://www.academia.edu/19323990/Effect_of_Difluoromethylornithine_on_Rectal_Mucosal_Levels_of_Polyamines_in_a_Randomized_Double_Blinded_Trial_for_Colon_Cancer_Prevention","translated_internal_url":"","created_at":"2015-12-01T15:09:39.093-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452383,"work_id":19323990,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2198257,"email":"s***n@u.washington.edu","display_order":0,"name":"Scot Emerson","title":"Effect of -Difluoromethylornithine on Rectal Mucosal Levels of Polyamines in a Randomized, Double-Blinded Trial for Colon Cancer Prevention"},{"id":11452385,"work_id":19323990,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688038,"email":"k***e@nuigalway.ie","display_order":4194304,"name":"Karen Doyle","title":"Effect of -Difluoromethylornithine on Rectal Mucosal Levels of Polyamines in a Randomized, Double-Blinded Trial for Colon Cancer Prevention"}],"downloadable_attachments":[],"slug":"Effect_of_Difluoromethylornithine_on_Rectal_Mucosal_Levels_of_Polyamines_in_a_Randomized_Double_Blinded_Trial_for_Colon_Cancer_Prevention","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39578858,"first_name":"Frank","middle_initials":null,"last_name":"Meyskens","page_name":"FrankMeyskens","domain_name":"independent","created_at":"2015-12-01T15:09:08.450-08:00","display_name":"Frank Meyskens","url":"https://independent.academia.edu/FrankMeyskens"},"attachments":[],"research_interests":[{"id":420802,"name":"Colon cancer","url":"https://www.academia.edu/Documents/in/Colon_cancer"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19323989"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19323989/Protein_kinase_C%CE%B2_expression_in_melanoma_cells_and_melanocytes_differential_expression_correlates_with_biological_responses_to_12_O_tetradecanoylphorbol_13_acetate"><img alt="Research paper thumbnail of Protein kinase Cβ expression in melanoma cells and melanocytes: differential expression correlates with biological responses to 12-O-tetradecanoylphorbol 13-acetate" class="work-thumbnail" src="https://attachments.academia-assets.com/42097991/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323989/Protein_kinase_C%CE%B2_expression_in_melanoma_cells_and_melanocytes_differential_expression_correlates_with_biological_responses_to_12_O_tetradecanoylphorbol_13_acetate">Protein kinase Cβ expression in melanoma cells and melanocytes: differential expression correlates with biological responses to 12-O-tetradecanoylphorbol 13-acetate</a></div><div class="wp-workCard_item"><span>Journal of Cancer Research and Clinical Oncology</span><span>, 1993</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Page 1. J Cancer Res Clin Oncol (1993) 119:199-206 Joum~lf Cancer esearch Ci nical @ncology 9 Spr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Page 1. J Cancer Res Clin Oncol (1993) 119:199-206 Joum~lf Cancer esearch Ci nical @ncology 9 Springer-Verlag 1993 Protein kinase C 13 expression in melanoma cells and melanocytes: differential expression correlates with ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="169af1fae48f33b4bd884c0d5102235d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42097991,"asset_id":19323989,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42097991/download_file?st=MTczMjQzMzc0Miw4LjIyMi4yMDguMTQ2&st=MTczMjQzMzc0MSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323989"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323989"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323989; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19323989]").text(description); $(".js-view-count[data-work-id=19323989]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19323989; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19323989']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19323989, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "169af1fae48f33b4bd884c0d5102235d" } } $('.js-work-strip[data-work-id=19323989]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19323989,"title":"Protein kinase Cβ expression in melanoma cells and melanocytes: differential expression correlates with biological responses to 12-O-tetradecanoylphorbol 13-acetate","translated_title":"","metadata":{"abstract":"Page 1. J Cancer Res Clin Oncol (1993) 119:199-206 Joum~lf Cancer esearch Ci nical @ncology 9 Springer-Verlag 1993 Protein kinase C 13 expression in melanoma cells and melanocytes: differential expression correlates with ...","publication_date":{"day":null,"month":null,"year":1993,"errors":{}},"publication_name":"Journal of Cancer Research and Clinical Oncology"},"translated_abstract":"Page 1. J Cancer Res Clin Oncol (1993) 119:199-206 Joum~lf Cancer esearch Ci nical @ncology 9 Springer-Verlag 1993 Protein kinase C 13 expression in melanoma cells and melanocytes: differential expression correlates with ...","internal_url":"https://www.academia.edu/19323989/Protein_kinase_C%CE%B2_expression_in_melanoma_cells_and_melanocytes_differential_expression_correlates_with_biological_responses_to_12_O_tetradecanoylphorbol_13_acetate","translated_internal_url":"","created_at":"2015-12-01T15:09:39.009-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452418,"work_id":19323989,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688058,"email":"r***7@columbia.edu","display_order":0,"name":"Richard Rosenberg","title":"Protein kinase Cβ expression in melanoma cells and melanocytes: differential expression correlates with biological responses to 12-O-tetradecanoylphorbol 13-acetate"}],"downloadable_attachments":[{"id":42097991,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42097991/thumbnails/1.jpg","file_name":"bf01624431.pdf20160204-18666-1aoqoo6","download_url":"https://www.academia.edu/attachments/42097991/download_file?st=MTczMjQzMzc0Miw4LjIyMi4yMDguMTQ2&st=MTczMjQzMzc0MSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Protein_kinase_C_expression_in_melanoma.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42097991/bf01624431-libre.pdf20160204-18666-1aoqoo6?1454634507=\u0026response-content-disposition=attachment%3B+filename%3DProtein_kinase_C_expression_in_melanoma.pdf\u0026Expires=1732437341\u0026Signature=f22ZrrWfHePKe2h4eikayjU8K8Gk04SNKJkIiWEanEaVB7uDC9TgIKyBEmWGWDOkY-VDPc9IC9jtEcbRc3-OHtXHY-yp~~9kh-EZKJ7gim9CUlViJh9-9jniUdDLMZzblQjfeNwvYeDG-NqKLB9pEfOh3xTJaCdkQsHSnjVumptRf-qNYTbliaC~n6Q1AWJrrfMMxRirklPFmr1DEeXI6VAvNagK9UyOhZfLujxgnMeu~QNEzqXmhdBMjN9tap6tZmBo~J5lTYV2rvpTSP4a2x-eBVWv3~D-B6iVeuan7YaKL8u1EJQfVbY63rXHUk3kzfHCKd41qVB5s5NyHXUoXg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Protein_kinase_Cβ_expression_in_melanoma_cells_and_melanocytes_differential_expression_correlates_with_biological_responses_to_12_O_tetradecanoylphorbol_13_acetate","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":39578858,"first_name":"Frank","middle_initials":null,"last_name":"Meyskens","page_name":"FrankMeyskens","domain_name":"independent","created_at":"2015-12-01T15:09:08.450-08:00","display_name":"Frank Meyskens","url":"https://independent.academia.edu/FrankMeyskens"},"attachments":[{"id":42097991,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42097991/thumbnails/1.jpg","file_name":"bf01624431.pdf20160204-18666-1aoqoo6","download_url":"https://www.academia.edu/attachments/42097991/download_file?st=MTczMjQzMzc0Miw4LjIyMi4yMDguMTQ2&st=MTczMjQzMzc0MSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Protein_kinase_C_expression_in_melanoma.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42097991/bf01624431-libre.pdf20160204-18666-1aoqoo6?1454634507=\u0026response-content-disposition=attachment%3B+filename%3DProtein_kinase_C_expression_in_melanoma.pdf\u0026Expires=1732437341\u0026Signature=f22ZrrWfHePKe2h4eikayjU8K8Gk04SNKJkIiWEanEaVB7uDC9TgIKyBEmWGWDOkY-VDPc9IC9jtEcbRc3-OHtXHY-yp~~9kh-EZKJ7gim9CUlViJh9-9jniUdDLMZzblQjfeNwvYeDG-NqKLB9pEfOh3xTJaCdkQsHSnjVumptRf-qNYTbliaC~n6Q1AWJrrfMMxRirklPFmr1DEeXI6VAvNagK9UyOhZfLujxgnMeu~QNEzqXmhdBMjN9tap6tZmBo~J5lTYV2rvpTSP4a2x-eBVWv3~D-B6iVeuan7YaKL8u1EJQfVbY63rXHUk3kzfHCKd41qVB5s5NyHXUoXg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":332356,"name":"Malignant Melanoma","url":"https://www.academia.edu/Documents/in/Malignant_Melanoma"},{"id":782254,"name":"Primary Culture","url":"https://www.academia.edu/Documents/in/Primary_Culture"},{"id":1954130,"name":"Cell Growth","url":"https://www.academia.edu/Documents/in/Cell_Growth"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19323988"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19323988/A_study_of_reproductive_function_in_patients_with_seminoma_treated_with_radiotherapy_and_orchidectomy_SWOG_8711_"><img alt="Research paper thumbnail of A study of reproductive function in patients with seminoma treated with radiotherapy and orchidectomy: (SWOG-8711)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19323988/A_study_of_reproductive_function_in_patients_with_seminoma_treated_with_radiotherapy_and_orchidectomy_SWOG_8711_">A study of reproductive function in patients with seminoma treated with radiotherapy and orchidectomy: (SWOG-8711)</a></div><div class="wp-workCard_item"><span>International Journal of Radiation Oncology*Biology*Physics</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The results of Southwest Oncology Group Study 8711 (Group 2B) are presented. The objective was to...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The results of Southwest Oncology Group Study 8711 (Group 2B) are presented. The objective was to evaluate the natural history of sperm concentration and selected hormonal parameters in patients with testicular cancer treated with orchiectomy and radiotherapy. Of a total of 207 patients enrolled on SWOG 8711, 53 pure seminoma patients were identified who were treated with orchiectomy and radiotherapy only. Sperm concentration, follicle-stimulating hormone (FSH) levels, and sexual satisfaction scores were the main parameters followed. A fraction of the patients were infertile prior to receiving radiotherapy. Our analysis indicates that incidental radiation dose to the remaining testicle affects time to recovery of fertility, and at an aggregate level, changes in FSH mirror changes in sperm concentration over time. This phenomenon is the same as that described in patients free from testicular cancer. These men evaluated their sexual activity as good after orchidectomy. Our data support the use of clamshell-type testicular shields as a means of providing maximum protection to the remaining testicle.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19323988"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19323988"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323988; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19323988]").text(description); $(".js-view-count[data-work-id=19323988]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19323988; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19323988']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 19323988, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19323988]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19323988,"title":"A study of reproductive function in patients with seminoma treated with radiotherapy and orchidectomy: (SWOG-8711)","translated_title":"","metadata":{"abstract":"The results of Southwest Oncology Group Study 8711 (Group 2B) are presented. The objective was to evaluate the natural history of sperm concentration and selected hormonal parameters in patients with testicular cancer treated with orchiectomy and radiotherapy. Of a total of 207 patients enrolled on SWOG 8711, 53 pure seminoma patients were identified who were treated with orchiectomy and radiotherapy only. Sperm concentration, follicle-stimulating hormone (FSH) levels, and sexual satisfaction scores were the main parameters followed. A fraction of the patients were infertile prior to receiving radiotherapy. Our analysis indicates that incidental radiation dose to the remaining testicle affects time to recovery of fertility, and at an aggregate level, changes in FSH mirror changes in sperm concentration over time. This phenomenon is the same as that described in patients free from testicular cancer. These men evaluated their sexual activity as good after orchidectomy. Our data support the use of clamshell-type testicular shields as a means of providing maximum protection to the remaining testicle.","publication_date":{"day":null,"month":null,"year":1997,"errors":{}},"publication_name":"International Journal of Radiation Oncology*Biology*Physics"},"translated_abstract":"The results of Southwest Oncology Group Study 8711 (Group 2B) are presented. The objective was to evaluate the natural history of sperm concentration and selected hormonal parameters in patients with testicular cancer treated with orchiectomy and radiotherapy. Of a total of 207 patients enrolled on SWOG 8711, 53 pure seminoma patients were identified who were treated with orchiectomy and radiotherapy only. Sperm concentration, follicle-stimulating hormone (FSH) levels, and sexual satisfaction scores were the main parameters followed. A fraction of the patients were infertile prior to receiving radiotherapy. Our analysis indicates that incidental radiation dose to the remaining testicle affects time to recovery of fertility, and at an aggregate level, changes in FSH mirror changes in sperm concentration over time. This phenomenon is the same as that described in patients free from testicular cancer. These men evaluated their sexual activity as good after orchidectomy. Our data support the use of clamshell-type testicular shields as a means of providing maximum protection to the remaining testicle.","internal_url":"https://www.academia.edu/19323988/A_study_of_reproductive_function_in_patients_with_seminoma_treated_with_radiotherapy_and_orchidectomy_SWOG_8711_","translated_internal_url":"","created_at":"2015-12-01T15:09:38.915-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39578858,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":11452400,"work_id":19323988,"tagging_user_id":39578858,"tagged_user_id":null,"co_author_invite_id":2688047,"email":"d***n@nwmissouri.edu","display_order":0,"name":"William Gordon","title":"A study of reproductive function in patients with seminoma treated with radiotherapy and orchidectomy: (SWOG-8711)"}],"downloadable_attachments":[],"slug":"A_study_of_reproductive_function_in_patients_with_seminoma_treated_with_radiotherapy_and_orchidectomy_SWOG_8711_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39578858,"first_name":"Frank","middle_initials":null,"last_name":"Meyskens","page_name":"FrankMeyskens","domain_name":"independent","created_at":"2015-12-01T15:09:08.450-08:00","display_name":"Frank Meyskens","url":"https://independent.academia.edu/FrankMeyskens"},"attachments":[],"research_interests":[{"id":4559,"name":"Reproduction","url":"https://www.academia.edu/Documents/in/Reproduction"},{"id":4571,"name":"Sex","url":"https://www.academia.edu/Documents/in/Sex"},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers"},{"id":963536,"name":"Sperm Count","url":"https://www.academia.edu/Documents/in/Sperm_Count"},{"id":1310139,"name":"Follicle stimulating hormone","url":"https://www.academia.edu/Documents/in/Follicle_stimulating_hormone"},{"id":1971275,"name":"Seminoma","url":"https://www.academia.edu/Documents/in/Seminoma"}],"urls":[]}, dispatcherData: dispatcherData }); 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