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During the last decades this vision became feasible and has been recently introduced in clinical" /> <title>(PDF) Tissue Engineering: A Boon to Tissue Regeneration | PULIPATI SOWJANYA - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/40188753/Tissue_Engineering_A_Boon_to_Tissue_Regeneration" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732452816000); window.Aedu.timeDifference = new Date().getTime() - 1732452816000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"The artificial generation of tissues, organs or even more complex living organisms was throughout the history of mankind a matter of myth and dream. During the last decades this vision became feasible and has been recently introduced in clinical medicine. Tissue engineering and regenerative medicine are terms in biomedical field that deal with the transformations. Tissue Engineering (TE) is a scientific field mainly focused on the development of tissue and organ substitutes by controlling biological, biophysical and/or biomechanical parameters in the laboratory. This results in elaboration of threedimensional cellular constructs with properties more similar to natural tissues than classical monolayer cultures. These systems enable the in-vitro study of human physiology and physiopathology more accurately, while providing a set of biomedical tools with potential applicability in toxicology, medical devices, tissue replacement, repair and regeneration. To succeed in these purposes, TE uses nature as an inspiration source for the generation of extracellular matrix analogues (scaffolds), either from natural or synthetic origin as well as bioreactors and bio-devices to mimic natural physiological conditions of particular tissues. These scaffolds embed cells in a three dimensional milieu that display signals critical for the determination of cellular fate, in terms of proliferation, differentiation and migration, among others. The aim of this review is to analyze the state of the art of TE and some of its application fields.","author":[{"@context":"https://schema.org","@type":"Person","name":"PULIPATI SOWJANYA"}],"contributor":[],"dateCreated":"2019-08-27","dateModified":"2019-08-27","datePublished":"2018-01-01","headline":"Tissue Engineering: A Boon to Tissue Regeneration","inLanguage":"en","keywords":["Microbiology","Biotechnology"],"locationCreated":null,"publication":"Inventi Rapid: Pharm Biotech \u0026 Microbio","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/40188753/Tissue_Engineering_A_Boon_to_Tissue_Regeneration","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":"university"}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-352e32ba4e89304dc0b4fa5b3952eef2198174c54cdb79066bc62e91c68a1a91.css" /><link 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"https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F40188753%2FTissue_Engineering_A_Boon_to_Tissue_Regeneration%3Fauto%3Ddownload"; window.loswp.translateUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F40188753%2FTissue_Engineering_A_Boon_to_Tissue_Regeneration%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":60412312,"identifier":"Attachment_60412312","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":40188753,"created_at":"2019-08-27T10:13:31.683-07:00","from_world_paper_id":null,"updated_at":"2021-01-12T16:53:02.980-08:00","_data":{"abstract":"The artificial generation of tissues, organs or even more complex living organisms was throughout the history of\nmankind a matter of myth and dream. During the last decades this vision became feasible and has been recently introduced in\nclinical medicine. Tissue engineering and regenerative medicine are terms in biomedical field that deal with the\ntransformations. Tissue Engineering (TE) is a scientific field mainly focused on the development of tissue and organ substitutes\nby controlling biological, biophysical and/or biomechanical parameters in the laboratory. This results in elaboration of threedimensional\ncellular constructs with properties more similar to natural tissues than classical monolayer cultures. These systems\nenable the in-vitro study of human physiology and physiopathology more accurately, while providing a set of biomedical tools\nwith potential applicability in toxicology, medical devices, tissue replacement, repair and regeneration. To succeed in these\npurposes, TE uses nature as an inspiration source for the generation of extracellular matrix analogues (scaffolds), either from\nnatural or synthetic origin as well as bioreactors and bio-devices to mimic natural physiological conditions of particular tissues.\nThese scaffolds embed cells in a three dimensional milieu that display signals critical for the determination of cellular fate, in\nterms of proliferation, differentiation and migration, among others. The aim of this review is to analyze the state of the art of TE\nand some of its application fields.","publication_date":"2018,,","publication_name":"Inventi Rapid: Pharm Biotech \u0026 Microbio"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Tissue Engineering: A Boon to Tissue Regeneration","broadcastable":true,"draft":false,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [27442451]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":60412312,"attachmentType":"pdf"}"><img alt="First page of “Tissue Engineering: A Boon to Tissue Regeneration”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/60412312/mini_magick20220705-9194-1giminy.png?1657068886" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Tissue Engineering: A Boon to Tissue Regeneration</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="27442451" href="https://university.academia.edu/SowjanyaPulipati"><img alt="Profile image of PULIPATI SOWJANYA" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/27442451/7810777/8753225/s65_sowjanya.pulipati.jpg" />PULIPATI SOWJANYA</a></div><p class="ds-work-card--detail ds2-5-body-sm">2018, Inventi Rapid: Pharm Biotech & Microbio</p><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">The artificial generation of tissues, organs or even more complex living organisms was throughout the history of mankind a matter of myth and dream. During the last decades this vision became feasible and has been recently introduced in clinical medicine. Tissue engineering and regenerative medicine are terms in biomedical field that deal with the transformations. Tissue Engineering (TE) is a scientific field mainly focused on the development of tissue and organ substitutes by controlling biological, biophysical and/or biomechanical parameters in the laboratory. This results in elaboration of threedimensional cellular constructs with properties more similar to natural tissues than classical monolayer cultures. These systems enable the in-vitro study of human physiology and physiopathology more accurately, while providing a set of biomedical tools with potential applicability in toxicology, medical devices, tissue replacement, repair and regeneration. To succeed in these purposes, TE uses nature as an inspiration source for the generation of extracellular matrix analogues (scaffolds), either from natural or synthetic origin as well as bioreactors and bio-devices to mimic natural physiological conditions of particular tissues. These scaffolds embed cells in a three dimensional milieu that display signals critical for the determination of cellular fate, in terms of proliferation, differentiation and migration, among others. The aim of this review is to analyze the state of the art of TE and some of its application fields.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":60412312,"attachmentType":"pdf","workUrl":"https://www.academia.edu/40188753/Tissue_Engineering_A_Boon_to_Tissue_Regeneration"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":60412312,"attachmentType":"pdf","workUrl":"https://www.academia.edu/40188753/Tissue_Engineering_A_Boon_to_Tissue_Regeneration"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="60412312" data-landing_url="https://www.academia.edu/40188753/Tissue_Engineering_A_Boon_to_Tissue_Regeneration" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="105711919" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/105711919/Biological_and_synthetic_scaffold_an_extra_cellular_matrix_for_constructive_tissue_engineering">Biological and synthetic scaffold: an extra cellular matrix for constructive tissue engineering</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" 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patient. To allow cellular adhesion, proliferation, and differentiation, the optimal scaffolds should have the right surface chemistry and microstructures. Furthermore, the scaffolds must have sufficient mechanical strength and a low rate of biodegradation with no unwanted by-products. Regenerative medicine efforts currently rely on the transplantation of cells in combination with supporting scaffolds and macromolecules to restore pathologically damaged tissue architectures. Biologically active scaffolds, which are based on analogues of the extracellular matrix that have spurred tissue and organ creation, have attracted a lot of attention in recent years. A scaffold is required to restore function or regenerate tissue, as it will serve as a temporary matrix for cell proliferation and extracellular matrix deposition, with further ingrowth until the tissues are completely restored or regenerated. Different technologies have been employed for fabrication of scaffolds for regeneration of different organs and tissues like skin, cartilage, bone, heart, lungs, liver and kidney. This review focuses on the different strategies used to construct the scaffold for the above-mentioned tissues and organs along with their commercial applications.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Recent Advances in Tissue Engineering Scaffolds and Commercial Applications","attachmentId":88327639,"attachmentType":"pdf","work_url":"https://www.academia.edu/82709263/Recent_Advances_in_Tissue_Engineering_Scaffolds_and_Commercial_Applications","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/82709263/Recent_Advances_in_Tissue_Engineering_Scaffolds_and_Commercial_Applications"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="2765534" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/2765534/The_Expanding_World_of_Tissue_Engineering_The_Building_Blocks_and_New_Applications_of_Tissue_Engineered_Constructs">The Expanding World of Tissue Engineering: The Building Blocks and New Applications of Tissue Engineered Constructs.</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="64010" href="https://unistra.academia.edu/NihalEnginVrana">Nihal Engin Vrana</a></div><p class="ds-related-work--abstract ds2-5-body-sm">The field of tissue engineering has been growing in the recent years as more products have made it to the market and as new uses for the engineered tissues have emerged, motivating many researchers to engage in this multidisciplinary field of research. Engineered tissues are now not only considered as end products for regenerative medicine, but also have emerged as enabling technologies for other fields of research ranging from drug discovery to biorobotics. This widespread use necessitates a variety of methodologies for production of tissue engineered constructs. In this review, these methods together with their non-clinical applications will be described. First, we will focus on novel materials used in tissue engineering scaffolds; such as recombinant proteins and synthetic, self assembling polypeptides. The recent advances in the modular tissue engineering area will be discussed. Then scaffold-free production methods, based on either cell sheets or cell aggregates will be described. Cell sources used in tissue engineering and new methods that provide improved control over cell behavior such as pathway engineering and biomimetic microenvironments for directing cell differentiation will be discussed. Finally, we will summarize the emerging uses of engineered constructs such as model tissues for drug discovery, cancer research and biorobotics applications.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Expanding World of Tissue Engineering: The Building Blocks and New Applications of Tissue Engineered Constructs.","attachmentId":30733453,"attachmentType":"pdf","work_url":"https://www.academia.edu/2765534/The_Expanding_World_of_Tissue_Engineering_The_Building_Blocks_and_New_Applications_of_Tissue_Engineered_Constructs","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/2765534/The_Expanding_World_of_Tissue_Engineering_The_Building_Blocks_and_New_Applications_of_Tissue_Engineered_Constructs"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="28330563" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/28330563/The_Crosstalk_between_Tissue_Engineering_and_Pharmaceutical_Biotechnology_Recent_Advances_and_Future_Directions">The Crosstalk between Tissue Engineering and Pharmaceutical Biotechnology: Recent Advances and Future Directions</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="3564781" href="https://up-pt.academia.edu/DanielaPacheco">Daniela Pacheco</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Tissue-engineered constructs made of biotechnology-derived materials have been preferred due to their chemical and physical composition, which offers both high versatility and a support to en-close/incorporate relevant signaling molecules and/or genes known to therapeutically induce tissue repair. Herein, a critical overview of the impact of different biotechnology-derived materials, scaffolds, and recombinant signaling molecules over the behavior of cells, another element of tissue engineered constructs, as well its regulatory role in tissue regeneration and disease progression is given. Additionally , these tissue-engineered constructs evolved to three-dimensional (3D) tissue-like models that, as an advancement of two-dimensional standard culture methods, are expected to be a valuable tool in the field of drug discovery and pharmaceutical research. Despite the improved design and conception of current proposed 3D tissue-like models, advanced control systems to enable and accelerate streamlining and automation of the numerous labor-intensive steps intrinsic to the development of tissue-engineered constructs are still to be achieved. In this sense, this review intends to present the biotechnology derived materials that are being explored in the field of tissue engineering to generate 3D tissue-analogues and briefly highlight their foremost breakthroughs in tissue regeneration and drug discovery. It also aims to reinforce that the crosstalk between tissue engineering and pharmaceutical biotechnology has been fostering the outcomes of tissue engineering approaches through the use of biotechnology-derived signaling molecules. Gene delivery/therapy is also discussed as a forefront area that represents another cross point between tissue engineering and pharmaceutical biotechnology, in which nucleic acids can be considered a "super pharmaceutical" to drive biological responses, including tissue regenera-tion.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Crosstalk between Tissue Engineering and Pharmaceutical Biotechnology: Recent Advances and Future Directions","attachmentId":48663468,"attachmentType":"pdf","work_url":"https://www.academia.edu/28330563/The_Crosstalk_between_Tissue_Engineering_and_Pharmaceutical_Biotechnology_Recent_Advances_and_Future_Directions","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/28330563/The_Crosstalk_between_Tissue_Engineering_and_Pharmaceutical_Biotechnology_Recent_Advances_and_Future_Directions"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="24505760" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/24505760/Three_dimensional_reconstituted_extracellular_matrix_scaffolds_for_tissue_engineering">Three-dimensional reconstituted extracellular matrix scaffolds for tissue engineering</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47232810" href="https://imb.academia.edu/KarthikeyanNarayanan">Karthikeyan Narayanan</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biomaterials, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Three-dimensional reconstituted extracellular matrix scaffolds for tissue engineering","attachmentId":44838373,"attachmentType":"pdf","work_url":"https://www.academia.edu/24505760/Three_dimensional_reconstituted_extracellular_matrix_scaffolds_for_tissue_engineering","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/24505760/Three_dimensional_reconstituted_extracellular_matrix_scaffolds_for_tissue_engineering"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":60412312,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":60412312,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_60412312" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="101589669" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/101589669/Tissue_Engineering_Current_Status_and_Futuristic_Scope">Tissue Engineering; Current Status & Futuristic Scope</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="172202773" href="https://independent.academia.edu/PDhot">Paramjit Dhot</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Medicine and Life, 2019</p><div class="ds-related-work--ctas"><button 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data-collection-position="1" data-entity-id="37670479" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/37670479/Engineering_extracellular_matrix_through_nanotechnology">Engineering extracellular matrix through nanotechnology</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="62540435" href="https://independent.academia.edu/CassandraKelleher">Cassandra Kelleher</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Engineering extracellular matrix through nanotechnology","attachmentId":57659316,"attachmentType":"pdf","work_url":"https://www.academia.edu/37670479/Engineering_extracellular_matrix_through_nanotechnology","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/37670479/Engineering_extracellular_matrix_through_nanotechnology"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="89144716" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/89144716/Biomaterials_for_Organ_and_Tissue_Regeneration">Biomaterials for Organ and Tissue Regeneration</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="28603460" href="https://inserm.academia.edu/JulienBarthes">Julien Barthes</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2020</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Biomaterials for Organ and Tissue Regeneration","attachmentId":92996247,"attachmentType":"pdf","work_url":"https://www.academia.edu/89144716/Biomaterials_for_Organ_and_Tissue_Regeneration","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/89144716/Biomaterials_for_Organ_and_Tissue_Regeneration"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="26608180" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/26608180/Biomimetic_approach_to_tissue_engineering">Biomimetic approach to tissue engineering</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50590655" href="https://independent.academia.edu/TimothyMartens">Timothy Martens</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Seminars in Cell & Developmental Biology, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Biomimetic approach to tissue engineering","attachmentId":46894533,"attachmentType":"pdf","work_url":"https://www.academia.edu/26608180/Biomimetic_approach_to_tissue_engineering","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/26608180/Biomimetic_approach_to_tissue_engineering"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="4" data-entity-id="66584683" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/66584683/Advanced_tools_for_tissue_engineering_scaffolds_bioreactors_and_signaling">Advanced tools for tissue engineering: scaffolds, bioreactors, and signaling</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="686138" href="https://mit.academia.edu/MarthaLGray">Martha L. Gray</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Advanced tools for tissue engineering: scaffolds, bioreactors, and signaling","attachmentId":77718260,"attachmentType":"pdf","work_url":"https://www.academia.edu/66584683/Advanced_tools_for_tissue_engineering_scaffolds_bioreactors_and_signaling","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/66584683/Advanced_tools_for_tissue_engineering_scaffolds_bioreactors_and_signaling"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="5" data-entity-id="24017244" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/24017244/A_multi_functional_scaffold_for_tissue_regeneration_The_need_to_engineer_a_tissue_analogue">A multi-functional scaffold for tissue regeneration: The need to engineer a tissue analogue</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="46191829" href="https://independent.academia.edu/FCausa">F. Causa</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biomaterials, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A multi-functional scaffold for tissue regeneration: The need to engineer a tissue analogue","attachmentId":44397012,"attachmentType":"pdf","work_url":"https://www.academia.edu/24017244/A_multi_functional_scaffold_for_tissue_regeneration_The_need_to_engineer_a_tissue_analogue","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/24017244/A_multi_functional_scaffold_for_tissue_regeneration_The_need_to_engineer_a_tissue_analogue"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="6" data-entity-id="90534288" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/90534288/Biometrology_in_Tissue_Engineering_Thoughts_and_Concepts">Biometrology in Tissue Engineering: Thoughts and Concepts</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="151681029" href="https://independent.academia.edu/FontesGiselle">Giselle Fontes</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Scientific and Industrial Metrology, 2017</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Biometrology in Tissue Engineering: Thoughts and Concepts","attachmentId":94071604,"attachmentType":"pdf","work_url":"https://www.academia.edu/90534288/Biometrology_in_Tissue_Engineering_Thoughts_and_Concepts","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/90534288/Biometrology_in_Tissue_Engineering_Thoughts_and_Concepts"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="7" data-entity-id="4357863" 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